ID | 14535 |
Eprint ID | 14535
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フルテキストURL | |
タイトル(別表記) | Clinical study on idiopathic thrombocytopenic purpura (ITP) Part 2. Analysis of the treatment of ITP and the value of colchicine therapy for the steroid resistant ITP
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著者 |
鶴見 尚和
岡山大学医学部第二内科学教室
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抄録 | Clinical effects of steroid and colchicine therapy in 49 patients with ITP especially the refractory cases were evaluated in comparison with splenectomy and danazol therapy.
There were 27(55%) steroid resistant patients who could not maintain platelet counts of 5×10(4)/μl with prednisolone doses of less than 10mg/day. Among the 16 steroid resistant patients treated with colchicine, there were 3 patients with complete remission and 3 others who had good to excellent response, that is, 6(37.5%) improved overall. This therapy was more effective than splenectomy (33.3%) and danazol (25%). Colchicine was did not effective in patients who did not respond to prednisolone, but was useful when patients showed at least a transient rise of the platelet count with prednisolone. In many cases, a response to colchicine was seen after a month, and in the patients who failed to show a rise in the platelet count after 2 months of colchicine therapy, no benefit was seen even when the therapy was continued. Colchicine is advantageous in the treatment of the steroid resistant ITP over the immunosuppressive agents or high-dose γ-globulin that are expensive and produce only a transient rise in the platelet count.
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キーワード | steroid resistant ITP
colchicine
danazol
splenectomy
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備考 | 原著
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発行日 | 1991
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出版物タイトル |
岡山医学会雑誌
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出版物タイトル(別表記) | Journal of Okayama Medical Association
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巻 | 103巻
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号 | 4号
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出版者 | 岡山医学会
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出版者(別表記) | Okayama Medical Association
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開始ページ | 373
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終了ページ | 386
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ISSN | 0030-1558
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NCID | AN00032489
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資料タイプ |
学術雑誌論文
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オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/103/4/103_4_373/_article/-char/ja/
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関連URL | http://www.okayama-u.ac.jp/user/oma/
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言語 |
日本語
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著作権者 | 岡山医学会
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論文のバージョン | publisher
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査読 |
有り
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Eprints Journal Name | joma
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