ID | 14024 |
Eprint ID | 14024
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フルテキストURL | |
タイトル(別表記) | Hemodialysis membrane with a negative charge : Modeling glomerular basement membrane
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著者 |
長宅 芳男
岡山大学医学部第三内科学教室
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抄録 | The glomerular basement membrane (GBM) regulates protein permeability by acting as both a size barrier and charge barrier. Since heparan sulfate-proteoglycan (HS-PG) which forms the charge barrier of the GBM contains a sulfonic acid base, we prepared negatively charged membranes by adding a sulfonic acid base to EVAL (ethylene vinyl alcohol) membranes. The permeabilities os the various proteins in these membranes were compared with those of conventional neutrally charged EVAL membranes. The permselectivity for proteins of negatively charged EVAL membranes depends largely upon the interrelation between the pore size of the membranes and size of the proteins. The negatively charged EVAL membranes had a higher selective permeability than the conventional neutrally charged EVAL membranes. Therefore, a negative charge within the dialyzer might produce higher selective permeability than conventional dialyzers.
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キーワード | 透析膜
腎糸球体基底膜
size barrier
charge barrier
スルホン酸基
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発行日 | 1993
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出版物タイトル |
岡山医学会雑誌
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出版物タイトル(別表記) | Journal of Okayama Medical Association
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巻 | 105巻
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号 | 3-4号
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出版者 | 岡山医学会
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出版者(別表記) | Okayama Medical Association
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開始ページ | 317
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終了ページ | 322
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ISSN | 0030-1558
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NCID | AN00032489
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資料タイプ |
学術雑誌論文
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オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/105/3-4/105_3-4_317/_article/-char/ja/
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関連URL | http://www.okayama-u.ac.jp/user/oma/index.html
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言語 |
日本語
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著作権者 | 岡山医学会
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論文のバージョン | publisher
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査読 |
有り
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Eprints Journal Name | joma
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