start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250410 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Enterobacterial common antigen repeat-unit flippase WzxE is required for Escherichia coli growth under acidic conditions, low temperature, and high osmotic stress conditions en-subtitle= kn-subtitle= en-abstract= kn-abstract=Colanic acid and enterobacterial common antigen (ECA) are cell-surface polysaccharides that are produced by many Escherichia coli isolates. Colanic acid is induced under acidic, low temperature, and high-salt conditions and is important for E. coli resistance to these stresses; however, the role of ECA in these stresses is less clear. Here, we observed that knockout of flippase wzxE, which translocates lipid-linked ECA repeat units from the cytoplasmic side of the inner membrane to the periplasmic side, resulted in the sensitivity of E. coli BW25113 to acidic conditions. The wzxE-knockout mutant showed reduced growth potential and viable counts in vegetable extracts with acidic environments, including cherry tomatoes, carrots, celery, lettuce, and spinach. A double-knockout strain of wzxE and wecF (glycosyltransferase that adds the third-and-final sugar of the lipid-linked ECA repeat unit) was not sensitive to acidic conditions, with similar results obtained for a double-knockout strain of wzxE and wcaJ (glycosyltransferase that initiates colanic acid lipid-linked repeat-unit biosynthesis). The wzxE-knockout mutant was sensitive to low temperatures or high-salt conditions, which induced colanic acid synthesis, and these sensitivities were abolished by the additional knockout of wcaJ. These results suggest that lipid-linked ECA repeat units confer E. coli susceptibility to acidic, low temperatures, and high-salt conditions in a colanic acid-dependent manner and that wzxE suppresses this negative effect. en-copyright= kn-copyright= en-aut-name=YamaguchiSaki en-aut-sei=Yamaguchi en-aut-mei=Saki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IshikawaKazuya en-aut-sei=Ishikawa en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FurutaKazuyuki en-aut-sei=Furuta en-aut-mei=Kazuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KaitoChikara en-aut-sei=Kaito en-aut-mei=Chikara kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=wzxE flippase kn-keyword=wzxE flippase en-keyword=enterobacterial common antigen kn-keyword=enterobacterial common antigen en-keyword=low pH kn-keyword=low pH en-keyword=low temperature kn-keyword=low temperature en-keyword=hyperosmotic stress kn-keyword=hyperosmotic stress END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue=7 article-no= start-page=2221 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Length Estimation of Pneumatic Artificial Muscle with Optical Fiber Sensor Using Machine Learning en-subtitle= kn-subtitle= en-abstract= kn-abstract=A McKibben artificial muscle is a soft actuator driven by air pressure, characterized by its flexibility, lightweight design, and high power-to-weight ratio. We have developed a smart artificial muscle that is capable of sensing its motion. To enable this sensing function, an optical fiber was integrated into the sleeve consisting of multiple fibers and serving as a component of the McKibben artificial muscle. By measuring the macrobending loss of the optical fiber, the length of the smart artificial muscle is expected to be estimated. However, experimental results indicated that the sensor's characteristics depend not only on the length but also on the load and the applied air pressure. This dependency arises because the stress applied to the optical fiber increases, causing microbending loss. In this study, we employed a machine learning model, primarily composed of Long Short-Term Memory (LSTM) neural networks, to estimate the length of the smart artificial muscle. The experimental results demonstrate that the length estimation obtained through machine learning exhibits a smaller error. This suggests that machine learning is a feasible approach to enhancing the length measurement accuracy of the smart artificial muscle. en-copyright= kn-copyright= en-aut-name=NiYilei en-aut-sei=Ni en-aut-mei=Yilei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WakimotoShuichi en-aut-sei=Wakimoto en-aut-mei=Shuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TianWeihang en-aut-sei=Tian en-aut-mei=Weihang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TodaYuichiro en-aut-sei=Toda en-aut-mei=Yuichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KandaTakefumi en-aut-sei=Kanda en-aut-mei=Takefumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamaguchiDaisuke en-aut-sei=Yamaguchi en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=McKibben artificial muscle kn-keyword=McKibben artificial muscle en-keyword=machine learning kn-keyword=machine learning en-keyword=optical fiber kn-keyword=optical fiber en-keyword=motion estimation kn-keyword=motion estimation END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue=7 article-no= start-page=2287 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250327 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Comparison of Midazolam and Diazepam for Sedation in Patients Undergoing Double-Balloon Endoscopic Retrograde Cholangiopancreatography: A Propensity Score-Matched Analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective: The sedation method used in double-balloon endoscopic retrograde cholangiopancreatography (DB-ERCP) varies across countries and between healthcare facilities. No previous studies have compared the effects of different benzodiazepines on sedation during endoscopic procedures. This study aimed to compare the effects of midazolam and diazepam sedation on DB-ERCP outcomes. Methods: This retrospective cohort study analyzed consecutive patients who underwent DB-ERCP between January 2017 and February 2024. A total of 203 patients who were sedated with diazepam (n = 94) or midazolam (n = 109) were analyzed. Propensity score matching was applied to adjust for baseline group differences. The primary outcome was the incidence of sedation-related adverse events (AEs). Secondary outcomes included inadequate sedation requiring additional sedatives and risk factors for sedation-related AEs. Results: Sedation-related AEs were more frequent with diazepam (28% [21/75]) than with midazolam (14% [11/75]; p = 0.046). Hypoxia occurred more frequently with diazepam (19% [14/75]) than with midazolam (5% [4/75]; p = 0.012). However, no significant differences were observed between the two groups for hypotension (p = 0.41) and bradycardia (p = 1.0). Poor sedation requiring other sedatives occurred significantly more often with diazepam (8% [6/75]) compared with midazolam sedation (0% [0/75], p = 0.012). Multivariate analysis identified diazepam sedation (odds ratio, 2.3; 95% confidence interval, 1.0-5.3; p = 0.048) as the sole risk factor for sedation-related AEs. Conclusions: Midazolam is safer and more effective than diazepam sedation in patients undergoing DB-ERCP. en-copyright= kn-copyright= en-aut-name=FujiiYuki en-aut-sei=Fujii en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsumotoKazuyuki en-aut-sei=Matsumoto en-aut-mei=Kazuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsumiAkihiro en-aut-sei=Matsumi en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiyamotoKazuya en-aut-sei=Miyamoto en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=UchidaDaisuke en-aut-sei=Uchida en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HoriguchiShigeru en-aut-sei=Horiguchi en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TsutsumiKoichiro en-aut-sei=Tsutsumi en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MitsuhashiToshiharu en-aut-sei=Mitsuhashi en-aut-mei=Toshiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OtsukaMotoyuki en-aut-sei=Otsuka en-aut-mei=Motoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=3 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=7 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= affil-num=8 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science kn-affil= en-keyword=adverse events kn-keyword=adverse events en-keyword=balloon-assisted ERCP kn-keyword=balloon-assisted ERCP en-keyword=benzodiazepine kn-keyword=benzodiazepine en-keyword=sedation kn-keyword=sedation END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The association between objectively measured physical activity and home blood pressure: a population-based real-world data analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Few studies have examined the association of objectively measured habitual physical activity (PA) and sedentary behavior with out-of-office blood pressure (BP). We investigated the associations of objectively measured PA intensity time, sedentary time, and step count with at-home BP. Using accelerometer-recorded PA indices and self-measured BP in 368 participants (mean age, 53.8 years; 58.7% women), we analyzed 115,575 records of each parameter between May 2019 and April 2024. PA intensities were categorized as light (2.0?2.9 metabolic equivalents [METs]); moderate (3.0?5.9 METs); vigorous (?6.0 METs), or sedentary (<2.0 METs): the median [interquartile ranges] for these variables was 188 [146?232], 83 [59?114], 1 [0?2], 501 [428?579] minutes, respectively, and for step count, was 6040 [4164?8457]. Means [standard deviations] for systolic and diastolic BP were 116.4 [14.2] and 75.2 [9.3] mmHg, respectively. A mixed-effect model adjusted for possible confounders showed that 1-h longer in vigorous PA was associated with lower systolic and diastolic BP (?1.69 and ?1.09?mmHg, respectively). A 1000-step increase in step count was associated with lower systolic and diastolic BP (?0.05 and ?0.02?mmHg, respectively). Associations were more pronounced among men and participants aged <60 years. Sedentary time was positively associated with BP in men and participants aged <60 years, but inversely associated with BP in women and participants aged ?60 years. Our findings suggest that more PA and less sedentary behavior were associated with BP reduction, particularly among men and participants aged <60 years. However, the clinical relevance of this effect remains uncertain because of its modest magnitude. en-copyright= kn-copyright= en-aut-name=KinutaMinako en-aut-sei=Kinuta en-aut-mei=Minako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HisamatsuTakashi en-aut-sei=Hisamatsu en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TaniguchiKaori en-aut-sei=Taniguchi en-aut-mei=Kaori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FukudaMari en-aut-sei=Fukuda en-aut-mei=Mari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakahataNoriko en-aut-sei=Nakahata en-aut-mei=Noriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KandaHideyuki en-aut-sei=Kanda en-aut-mei=Hideyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Environmental Medicine and Public Health, Izumo, Shimane University Faculty of Medicine kn-affil= affil-num=4 en-affil=Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Health and Nutrition, The University of Shimane Faculty of Nursing and Nutrition kn-affil= affil-num=6 en-affil=Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol=213 cd-vols= no-issue= article-no= start-page=128 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The potential mechanism maintaining transactive response DNA binding protein 43?kDa in the mouse stroke model en-subtitle= kn-subtitle= en-abstract= kn-abstract=The disruption of transactive response DNA binding protein 43?kDa (TDP-43) shuttling leads to the depletion of nuclear localization and the cytoplasmic accumulation of TDP-43. We aimed to evaluate the mechanism underlying the behavior of TDP-43 in ischemic stroke. Adult male C57BL/6?J mice were subjected to 30 or 60?min of transient middle cerebral artery occlusion (tMCAO), and examined at 1, 6, and 24?h post reperfusion. Immunostaining was used to evaluate the expression of TDP-43, G3BP1, HDAC6, and RAD23B. The total and cytoplasmic number of TDP-43?positive cells increased compared with sham operation group and peaked at 6?h post reperfusion after tMCAO. The elevated expression of G3BP1 protein peaked at 6?h after reperfusion and decreased at 24?h after reperfusion in ischemic mice brains. We also observed an increase of expression level of HDAC6 and the number of RAD23B-positive cells increased after tMCAO. RAD23B was colocalized with TDP-43 24?h after tMCAO. We proposed that the formation of stress granules might be involved in the mislocalization of TDP-43, based on an evaluation of G3BP1 and HDAC6. Subsequently, RAD23B, may also contribute to the downstream degradation of mislocalized TDP-43 in mice tMCAO model. en-copyright= kn-copyright= en-aut-name=BianYuting en-aut-sei=Bian en-aut-mei=Yuting kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FukuiYusuke en-aut-sei=Fukui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=Ota-ElliottRicardo Satoshi en-aut-sei=Ota-Elliott en-aut-mei=Ricardo Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HuXinran en-aut-sei=Hu en-aut-mei=Xinran kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SunHongming en-aut-sei=Sun en-aut-mei=Hongming kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=BianZhihong en-aut-sei=Bian en-aut-mei=Zhihong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ZhaiYun en-aut-sei=Zhai en-aut-mei=Yun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YuHaibo en-aut-sei=Yu en-aut-mei=Haibo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HuXiao en-aut-sei=Hu en-aut-mei=Xiao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=AnHangping en-aut-sei=An en-aut-mei=Hangping kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=LiuHongzhi en-aut-sei=Liu en-aut-mei=Hongzhi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=IshiuraHiroyuki en-aut-sei=Ishiura en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=13 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=14 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=TDP-43 kn-keyword=TDP-43 en-keyword=ALS kn-keyword=ALS en-keyword=RNA-binding protein kn-keyword=RNA-binding protein en-keyword=Mislocalization kn-keyword=Mislocalization en-keyword=G3BP1 kn-keyword=G3BP1 en-keyword=HDAC6 kn-keyword=HDAC6 en-keyword=RAD23B kn-keyword=RAD23B en-keyword=tMCAO kn-keyword=tMCAO END start-ver=1.4 cd-journal=joma no-vol=2024 cd-vols= no-issue=12 article-no= start-page=135 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20241217 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Elliptic virtual structure constants and generalizations of BCOV-Zinger formula to projective Fano hypersurfaces en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this paper, we propose a method for computing genus 1 Gromov-Witten invariants of Calabi-Yau and Fano projective hypersurfaces using the B-model. Our formalism is applicable to both Calabi-Yau and Fano cases. In the Calabi-Yau case, significant cancellation of terms within our formalism occurs, resulting in an alternative representation of the BCOV-Zinger formula for projective Calabi-Yau hypersurfaces. en-copyright= kn-copyright= en-aut-name=JinzenjiMasao en-aut-sei=Jinzenji en-aut-mei=Masao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KuwataKen en-aut-sei=Kuwata en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Department of Mathematics, Okayama University kn-affil= affil-num=2 en-affil=Department of General Education, National Institute of Technology, Kagawa College kn-affil= en-keyword=Nonperturbative Effects kn-keyword=Nonperturbative Effects en-keyword=String Duality kn-keyword=String Duality en-keyword=Topological Field Theories kn-keyword=Topological Field Theories en-keyword=Topological Strings kn-keyword=Topological Strings END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=— •\Ž†E‰p•¶–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=“Še‹K’öE‰œ•t en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=47 end-page=55 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Practical BIZEN Device Design Course Activity Report in Fiscal 2024 kn-title=2024”N“xŽŸ¢‘ãˆã—Ë@ŠíŠJ”­lވ笃vƒƒOƒ‰ƒ€BIZENƒfƒoƒCƒXƒfƒUƒCƒ“ƒR[ƒX‚ÌŽæ‚è‘g‚Ý en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TSUZUKITsuneaki en-aut-sei=TSUZUKI en-aut-mei=Tsuneaki kn-aut-name=“s’zí–¾ kn-aut-sei=“s’z kn-aut-mei=í–¾ aut-affil-num=1 ORCID= en-aut-name=UCHIDADaisuke en-aut-sei=UCHIDA en-aut-mei=Daisuke kn-aut-name=“à“c‘å•ã kn-aut-sei=“à“c kn-aut-mei=‘å•ã aut-affil-num=2 ORCID= en-aut-name=KISHIMOTOToshio en-aut-sei=KISHIMOTO en-aut-mei=Toshio kn-aut-name=ŠÝ–{r•v kn-aut-sei=ŠÝ–{ kn-aut-mei=r•v aut-affil-num=3 ORCID= en-aut-name=SENGOKUYoshinari en-aut-sei=SENGOKU en-aut-mei=Yoshinari kn-aut-name=åΊì–ç kn-aut-sei=åÎ kn-aut-mei=Šì–ç aut-affil-num=4 ORCID= en-aut-name=KORENAGAToshio en-aut-sei=KORENAGA en-aut-mei=Toshio kn-aut-name=ˆÉ‰ir—Y kn-aut-sei=ˆÉ‰i kn-aut-mei=r—Y aut-affil-num=5 ORCID= en-aut-name=HITOBEYu en-aut-sei=HITOBE en-aut-mei=Yu kn-aut-name=l•”—F kn-aut-sei=l•” kn-aut-mei=—F aut-affil-num=6 ORCID= en-aut-name=YOSHIBAYasuyuki en-aut-sei=YOSHIBA en-aut-mei=Yasuyuki kn-aut-name=‹g—t‹±s kn-aut-sei=‹g—t kn-aut-mei=‹±s aut-affil-num=7 ORCID= en-aut-name=SAKURAIJun en-aut-sei=SAKURAI en-aut-mei=Jun kn-aut-name=ŸNˆä~ kn-aut-sei=ŸNˆä kn-aut-mei=~ aut-affil-num=8 ORCID= affil-num=1 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@ Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ affil-num=2 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@ Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ affil-num=3 en-affil=Organization for Research Strategy and Development, Okayama University kn-affil=‰ªŽR‘åŠw Œ¤‹†EƒCƒmƒx[ƒVƒ‡ƒ“‹¤‘n‹@\ affil-num=4 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@ Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ affil-num=5 en-affil=Organization for Research Strategy and Development, Okayama University kn-affil=‰ªŽR‘åŠw Œ¤‹†EƒCƒmƒx[ƒVƒ‡ƒ“‹¤‘n‹@\ affil-num=6 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@ Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ affil-num=7 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=8 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@ Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=39 end-page=45 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Practicing the Innovation Loop: 2024 Report on Advanced Hospital Practicums and Future Challenges kn-title=ƒCƒmƒx[ƒVƒ‡ƒ“ƒ‹[ƒv‚ÌŽÀ‘HF2024”N“xæi•a‰@ŽÀK•ñ‚Æ–¢—ˆ‰Û‘è en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HARADANahoko en-aut-sei=HARADA en-aut-mei=Nahoko kn-aut-name=Œ´“c“Þ•äŽq kn-aut-sei=Œ´“c kn-aut-mei=“Þ•äŽq aut-affil-num=1 ORCID= en-aut-name=TAKAHASHISatoshi en-aut-sei=TAKAHASHI en-aut-mei=Satoshi kn-aut-name=ûü‹´’q kn-aut-sei=ûü‹´ kn-aut-mei=’q aut-affil-num=2 ORCID= en-aut-name=MORITomoaki en-aut-sei=MORI en-aut-mei=Tomoaki kn-aut-name=X—F–¾ kn-aut-sei=X kn-aut-mei=—F–¾ aut-affil-num=3 ORCID= en-aut-name=HIKASAHaruka en-aut-sei=HIKASA en-aut-mei=Haruka kn-aut-name=“úŠ}° kn-aut-sei=“úŠ} kn-aut-mei=° aut-affil-num=4 ORCID= en-aut-name=SHISHIDOKeisuke en-aut-sei=SHISHIDO en-aut-mei=Keisuke kn-aut-name=Ž³ŒËŒ\‰î kn-aut-sei=Ž³ŒË kn-aut-mei=Œ\‰î aut-affil-num=5 ORCID= en-aut-name=MAGARIMasaki en-aut-sei=MAGARI en-aut-mei=Masaki kn-aut-name=‹È³Ž÷ kn-aut-sei=‹È kn-aut-mei=³Ž÷ aut-affil-num=6 ORCID= en-aut-name=WATANABEToyohiko en-aut-sei=WATANABE en-aut-mei=Toyohiko kn-aut-name=“nç³–L•F kn-aut-sei=“nç³ kn-aut-mei=–L•F aut-affil-num=7 ORCID= en-aut-name=WangJin en-aut-sei=Wang en-aut-mei=Jin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MORITAMizuki en-aut-sei=MORITA en-aut-mei=Mizuki kn-aut-name=X“cŽ÷ kn-aut-sei=X“c kn-aut-mei=Ž÷ aut-affil-num=9 ORCID= affil-num=1 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=2 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=3 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=4 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=5 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=6 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=7 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=8 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=9 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems Health Sciences, Okayama university kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=35 end-page=37 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 16th International Symposium for Future Technology Creating Better Human Health and Society kn-title=‘æ16‰ñ ‚“xˆã—ÓsŽs‚ð‘no‚·‚é–¢—ˆ‹Zp‘ÛƒVƒ“ƒ|ƒWƒEƒ€ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YANGJiajia en-aut-sei=YANG en-aut-mei=Jiajia kn-aut-name=—k‰Æ‰Æ kn-aut-sei=—k kn-aut-mei=‰Æ‰Æ aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ª??ŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=29 end-page=33 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Survey of Private Collections gKyoson Collectionsh in Okayama University Library: Focusing on His Friendship with Poets kn-title=‰ªŽR‘åŠw’†‰›}‘ŠÙEŒÂl•¶ŒÉuˆÇ‘º•¶ŒÉv‚Ì’²¸FŽl‚Æ‚ÌŒð—F‚ð’†S‚É en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SUZUKIRyozo en-aut-sei=SUZUKI en-aut-mei=Ryozo kn-aut-name=—é–Ø—ºŽO kn-aut-sei=—é–Ø kn-aut-mei=—ºŽO aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=19 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Review of Previous Research on the Use of PrEP: Focusing on Japan and China kn-title=PrEP ‚Ì—˜—p‚ÉŠÖ‚·‚éæsŒ¤‹†ƒŒƒrƒ…[“ú–{‚Æ’†‘‚ð’†S‚É en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WangDecheng en-aut-sei=Wang en-aut-mei=Decheng kn-aut-name=ŸŠ“¿¬ kn-aut-sei=ŸŠ kn-aut-mei=“¿¬ aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŒ¤‹†‰È en-keyword=PrEP (Pre-exposure Prophylaxis) kn-keyword=PrEP (Pre-exposure Prophylaxis) en-keyword=HIV Prevention kn-keyword=HIV Prevention en-keyword=Social Stigma kn-keyword=Social Stigma en-keyword=Policy Support kn-keyword=Policy Support en-keyword=Regional Disparities kn-keyword=Regional Disparities END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=11 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An examination of decision-making support at the end of life on relational autonomy theory kn-title=ŠÖŒW“IŽ©—¥—˜_‚ÉŠî‚¢‚½I––Šú‚ÉŠÖ‚·‚éˆÓŽvŒˆ’èŽx‰‡‚ÌŒŸ“¢ en-subtitle= kn-subtitle= en-abstract= kn-abstract=In contemporary end-of-life care, it is difficult for patients to make decisions without the influence of society, family, and other factors. In many cases, patients have the capacity to make the decisions; nevertheless, they have difficulty expressing their own will because of the influence of their relationships and environment. Patient concerns about the burden of care and also the social and economic impacts on family members often hinder their use of imagination and decision-making. Therefore, this study has examined how patients with decision-making capacities could achieve autonomy under the influence of their relationships with their surroundings. The method of decision-making support provided by nurses to patients was examined using relational autonomy theory. Relational autonomy theory attempts to reconceptualize autonomy through feminists who criticize individualist theories of autonomy. en-copyright= kn-copyright= en-aut-name=SONOYAMASumiyo en-aut-sei=SONOYAMA en-aut-mei=Sumiyo kn-aut-name=‰€ŽRƒ‘ã kn-aut-sei=‰€ŽR kn-aut-mei=ƒ‘ã aut-affil-num=1 ORCID= affil-num=1 en-affil=The University of Shimane kn-affil=“‡ªŒ§—§‘åŠw en-keyword=relational autonomy kn-keyword=relational autonomy en-keyword=decision-making kn-keyword=decision-making en-keyword=end of life care kn-keyword=end of life care END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=1 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Corporate decision-making process for exploration time kn-title=’m‚Ì’TõŽžŠÔ‚ɂ‚¢‚Ä‚ÌŠé‹Æ‚̈ӎvŒˆ’èƒvƒƒZƒX en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order for companies to innovate through business co-creation, it is necessary to explore a wide range of external knowledge and technologies. However, there is no clear answer as to how much time should be spent for exploration. Under these circumstances, companies must take into account constraints such as the amount of management resources that can be invested, and make decisions about the time to spend for exploration. The purpose of this paper is to clarify the process of how companies that have introduced corporate accelerator program recognize the relationship between the program period and the results of business co-creation, and how they make decisions about the program period. We conducted a case study of several companies that have introduced corporate accelerator program in Japan. In addition, this paper established a hypothesis about decision-making about the time for exploration from case studies. en-copyright= kn-copyright= en-aut-name=SHIMIZUTakeshi en-aut-sei=SHIMIZU en-aut-mei=Takeshi kn-aut-name=Žu…•Žj kn-aut-sei=Žu… kn-aut-mei=•Žj aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems Okayama University kn-affil=‘—§‘åŠw–@l‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŒ¤‹†Šwˆæ en-keyword=corporate accelerator program kn-keyword=corporate accelerator program en-keyword=co-creation kn-keyword=co-creation en-keyword=exploration kn-keyword=exploration en-keyword=Time Compression Diseconomies kn-keyword=Time Compression Diseconomies END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž†E–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue=3 article-no= start-page=e0320482 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Serum uric acid level is associated with renal arteriolar hyalinosis and predicts post-donation renal function in living kidney donors en-subtitle= kn-subtitle= en-abstract= kn-abstract=Major guidelines for living-donor kidney transplantation underscore the need for pre-donation evaluation of renal function, hypertension, obesity, diabetes mellitus, and albuminuria to minimize the risk of donation from marginal donors. However, validity is yet to be established. We retrospectively investigated the relationship between clinical characteristics and histological indices in baseline renal biopsies (0-h biopsies) and whether these parameters could predict renal function in living kidney donors one year post-donation. Seventy-six living kidney donors were recruited for this study. In histological analyses, glomerulosclerosis, arteriosclerosis, arteriolosclerosis, arteriolar hyalinosis, and interstitial fibrosis and tubular atrophy scores/indices were evaluated. Post-donation serum creatinine levels in kidney donors with arteriolar hyalinosis were significantly higher than those in individuals without arteriolar hyalinosis. There was a significant correlation between baseline serum uric acid levels and the arteriolar hyalinosis index, with baseline uric acid level identified as an independent factor for hyalinosis in multiple regression analysis. Additionally, the serum uric acid level was a significant prognostic factor for post-donation serum creatinine after adjustment for baseline clinical parameters. These data demonstrate that pre-donation serum uric acid levels are associated with arteriolar hyalinosis in the kidney and could predict a decline in renal function during the first year after donation in living kidney donors. en-copyright= kn-copyright= en-aut-name=KanoYuzuki en-aut-sei=Kano en-aut-mei=Yuzuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanabeKatsuyuki en-aut-sei=Tanabe en-aut-mei=Katsuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KitagawaMasashi en-aut-sei=Kitagawa en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SugiyamaHitoshi en-aut-sei=Sugiyama en-aut-mei=Hitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamanoiTomoaki en-aut-sei=Yamanoi en-aut-mei=Tomoaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YoshinagaKasumi en-aut-sei=Yoshinaga en-aut-mei=Kasumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=BekkuKensuke en-aut-sei=Bekku en-aut-mei=Kensuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NishimuraShingo en-aut-sei=Nishimura en-aut-mei=Shingo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Medicine, Kawasaki Medical School General Medical Center and Department of Medical Care Work, Kawasaki College of Health Professions kn-affil= affil-num=5 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=4 article-no= start-page=e70139 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Induction Therapy With Oral Tacrolimus Provides Long-Term Benefit in Thiopurine-Na?ve Refractory Ulcerative Colitis Patients Despite Low Serum Albumin Levels en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background and Aim: Oral tacrolimus is an effective treatment for refractory ulcerative colitis (UC). However, tacrolimus is underutilized because of the difficulties in transitioning to subsequent maintenance therapy and concerns about adverse events.
Methods: We evaluated the clinical outcomes, adverse events, and accumulated medication costs in consecutive 72 UC patients treated with tacrolimus.
Results: Fifty-five (76%) patients with pancolitis and 43 (60%) patients with acute severe disease were entered. Fifty-four (75%) achieved clinical remission 8 weeks after starting tacrolimus. At the last visit, 62 (86%) patients had colectomy-free remission, and 55 (76%) patients had corticosteroid-free remission. Eighteen (25%) patients maintained remission without additional treatment after tacrolimus discontinuation. Patients with continuous remission had a significantly lower history of thiopurine use and lower serum albumin levels at the induction of tacrolimus than patients with failure to induce or maintain remission. No severe adverse events due to tacrolimus treatment were observed. The accumulated medication costs over 3 years in patients with continuous remission after the start of tacrolimus were lower than those in patients with induction and maintenance of infliximab (p < 0.001).
Conclusions: Tacrolimus could have an irreplaceable role in the era of biologic therapies, especially for refractory UC patients with thiopurine-na & iuml;ve and low serum albumin levels. en-copyright= kn-copyright= en-aut-name=IgawaShoko en-aut-sei=Igawa en-aut-mei=Shoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=InokuchiToshihiro en-aut-sei=Inokuchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HiraokaSakiko en-aut-sei=Hiraoka en-aut-mei=Sakiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ToyosawaJunki en-aut-sei=Toyosawa en-aut-mei=Junki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AoyamaYuki en-aut-sei=Aoyama en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamasakiYasushi en-aut-sei=Yamasaki en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KinugasaHideaki en-aut-sei=Kinugasa en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakaharaMasahiro en-aut-sei=Takahara en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OtsukaMotoyuki en-aut-sei=Otsuka en-aut-mei=Motoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=biologics therapy kn-keyword=biologics therapy en-keyword=tacrolimus kn-keyword=tacrolimus en-keyword=thiopurine kn-keyword=thiopurine en-keyword=ulcerative colitis kn-keyword=ulcerative colitis END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=10462 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250326 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Gingipain regulates isoform switches of PD-L1 in macrophages infected with Porphyromonas gingivalis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Periodontal pathogen Porphyromonas gingivalis (P. gingivalis) is believed to possess immune evasion capabilities, but it remains unclear whether this immune evasion is related to host gene alternative splicing (AS). In this study, RNA-sequencing revealed significant changes in both AS landscape and transcriptomic profile of macrophages following P. gingivalis infection with/without knockout of gingipain (a unique toxic protease of P. gingivalis). P. gingivalis infection increased the PD-L1 transcripts expression and selectively upregulated a specific coding isoform that more effectively binds to PD-1 on T cells, thereby inhibiting immune function. Biological experiments also detected AS switch of PD-L1 in P. gingivalis-infected or gingipain-treated macrophages. AlphaFold 3 predictions indicated that the protein docking compatibility between PD-1 and P. gingivalis-upregulated PD-L1 isoform was over 80% higher than another coding isoform. These findings suggest that P. gingivalis employs gingipain to modulate the AS of PD-L1, facilitating immune evasion. en-copyright= kn-copyright= en-aut-name=ZhengYilin en-aut-sei=Zheng en-aut-mei=Yilin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WangZiyi en-aut-sei=Wang en-aut-mei=Ziyi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WengYao en-aut-sei=Weng en-aut-mei=Yao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SitosariHeriati en-aut-sei=Sitosari en-aut-mei=Heriati kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HeYuhan en-aut-sei=He en-aut-mei=Yuhan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ZhangXiu en-aut-sei=Zhang en-aut-mei=Xiu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShiotsuNoriko en-aut-sei=Shiotsu en-aut-mei=Noriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=FukuharaYoko en-aut-sei=Fukuhara en-aut-mei=Yoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=IkegameMika en-aut-sei=Ikegame en-aut-mei=Mika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OkamuraHirohiko en-aut-sei=Okamura en-aut-mei=Hirohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama University kn-affil= affil-num=2 en-affil=Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama University kn-affil= affil-num=4 en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama University kn-affil= affil-num=5 en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama University kn-affil= affil-num=6 en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama University kn-affil= affil-num=7 en-affil=Comprehensive Dental Clinic, Okayama University Hospital, Okayama University kn-affil= affil-num=8 en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama University kn-affil= affil-num=9 en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama University kn-affil= affil-num=10 en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Hospital, Okayama University kn-affil= en-keyword=Porphyromonas gingivalis kn-keyword=Porphyromonas gingivalis en-keyword=Gingipain kn-keyword=Gingipain en-keyword=Macrophage kn-keyword=Macrophage en-keyword=Alternative splicing kn-keyword=Alternative splicing en-keyword=PD-L1 kn-keyword=PD-L1 en-keyword=Immune evasion kn-keyword=Immune evasion END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=1547222 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250311 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways en-subtitle= kn-subtitle= en-abstract= kn-abstract=Aims: Cathepsins are essential lysosomal enzymes that maintain organismal homeostasis by degrading extracellular substrates. The inflammatory cytokine interleukin-6 (IL-6) increases the production of cathepsins through the caveolin-1 (Cav-1) and c-Jun N-terminal kinase (JNK) signaling pathways, which have been implicated in the destruction of periodontal tissue. This study investigated the effect of the IL-6/soluble IL-6 receptor (sIL-6R) complex on the extracellular secretion of cathepsins in human gingival fibroblasts (HGFs) and examined the function of extracellularly secreted cathepsins B and L under acidic culture conditions in vitro.
Methods: HGFs were isolated from healthy volunteer donors. The expression of Cav-1 was suppressed via transfection with small interfering RNA (siRNA) targeting Cav-1. The expression levels of cathepsins B and L induced by extracellular IL-6/sIL-6R were measured using western blotting and enzyme-linked immunosorbent assay. Extracellular cathepsin activity following IL-6/sIL-6R stimulation was assessed using a methylcoumarylamide substrate in a fluorescence-based assay. IL-6/sIL-6R-induced expression of cathepsins B and L in HGFs was quantified under inhibitory conditions for extracellular signal-regulated kinase (ERK) 1/2 and/or JNK signaling, both of which are transduction pathways activated by IL-6/sIL-6R. This quantification was also performed in HGFs with suppressed Cav-1 expression using western blotting.
Results: Cathepsins B and L were secreted in their precursor forms from HGFs, with significantly elevated protein levels observed at 24, 48, and 72 h post-IL-6/sIL-6R stimulation. Under acidic culture conditions, cathepsin B activity increased at 48 and 72 h. Cav-1 suppression inhibited the secretion of cathepsin B regardless of IL-6/sIL-6R stimulation, whereas the secretion of cathepsin L was reduced only after 48 h of IL-6/sIL-6R stimulation. Inhibition of ERK1/2 and JNK pathways decreased the secretion of cathepsin B after 48 h of IL-6/sIL-6R stimulation, and JNK inhibition reduced the secretion of cathepsin L under similar conditions.
Conclusion: IL-6/sIL-6R stimulation increased the extracellular secretion of cathepsin B and L precursors in HGFs, and these precursors became activated under acidic conditions. Cav-1 and ERK1/2 are involved in regulating the secretion of cathepsin B precursors. en-copyright= kn-copyright= en-aut-name=GotoAyaka en-aut-sei=Goto en-aut-mei=Ayaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OmoriKazuhiro en-aut-sei=Omori en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=Yamaguchi-TomikawaTomoko en-aut-sei=Yamaguchi-Tomikawa en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KobayashiHiroya en-aut-sei=Kobayashi en-aut-mei=Hiroya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=Shinoda-ItoYuki en-aut-sei=Shinoda-Ito en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HiraiKimito en-aut-sei=Hirai en-aut-mei=Kimito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IkedaAtsushi en-aut-sei=Ikeda en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakashibaShogo en-aut-sei=Takashiba en-aut-mei=Shogo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Periodontics & Endodontics, Division of Dentistry, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=cathepsin B kn-keyword=cathepsin B en-keyword=cathepsin L kn-keyword=cathepsin L en-keyword=human gingival fibroblast kn-keyword=human gingival fibroblast en-keyword=interleukin-6 kn-keyword=interleukin-6 en-keyword=caveolin kn-keyword=caveolin END start-ver=1.4 cd-journal=joma no-vol=301 cd-vols= no-issue=4 article-no= start-page=108334 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202504 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Roles of basic amino acid residues in substrate binding and transport of the light-driven anion pump Synechocystis halorhodopsin (SyHR) en-subtitle= kn-subtitle= en-abstract= kn-abstract=Microbial rhodopsins are photoreceptive seventransmembrane a-helical proteins, many of which function as ion transporters, primarily for small monovalent ions such as Na+, K+, Cl-, Br-, and I-. Synechocystis halorhodopsin (SyHR), identified from the cyanobacterium Synechocystis sp. PCC 7509, uniquely transports the polyatomic divalent SO42- inward, in addition to monovalent anions (Cl- and Br-). In this study, we conducted alanine-scanning mutagenesis on twelve basic amino acid residues to investigate the anion transport mechanism of SyHR. We quantitatively evaluated the Cl-and SO42- transport activities of the WT SyHR and its mutants. The results showed a strong correlation between the Cl-and SO42- transport activities among them (R = 0.94), suggesting a shared pathway for both anions. Notably, the R71A mutation selectively abolished SO42- transport activity while maintaining Cl- transport, whereas the H167A mutation significantly impaired both Cl-and SO42- transport. Furthermore, spectroscopic analysis revealed that the R71A mutant lost its ability to bind SO42- due to the absence of a positive charge, while the H167A mutant failed to accumulate the O intermediate during the photoreaction cycle (photocycle) due to reduced hydrophilicity. Additionally, computational analysis revealed the SO42- binding modes and clarified the roles of residues involved in its binding around the retinal chromophore. Based on these findings and previous structural information, we propose that the positive charge and hydrophilicity of Arg71 and His167 are crucial for the formation of the characteristic initial and transient anion-binding site of SyHR, enabling its unique ability to bind and transport both Cl-and SO42-. en-copyright= kn-copyright= en-aut-name=NakamaMasaki en-aut-sei=Nakama en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NojiTomoyasu en-aut-sei=Noji en-aut-mei=Tomoyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KojimaKeiichi en-aut-sei=Kojima en-aut-mei=Keiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YoshizawaSusumu en-aut-sei=Yoshizawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IshikitaHiroshi en-aut-sei=Ishikita en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SudoYuki en-aut-sei=Sudo en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Applied Chemistry, The University of Tokyo kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Atmosphere and Ocean Research Institute, The University of Tokyo kn-affil= affil-num=5 en-affil=Department of Applied Chemistry, The University of Tokyo kn-affil= affil-num=6 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=microbial rhodopsin kn-keyword=microbial rhodopsin en-keyword=anion transport kn-keyword=anion transport en-keyword=retinal kn-keyword=retinal en-keyword=membrane protein kn-keyword=membrane protein en-keyword=photobiology kn-keyword=photobiology END start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue= article-no= start-page=670 end-page=679 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Photochemically assisted synthesis of phenacenes fluorinated at the terminal benzene rings and their electronic spectra en-subtitle= kn-subtitle= en-abstract= kn-abstract=[n]Phenacenes ([n] = 5-7), octafluorinated at the terminal benzene rings (F8-phenacenes: F8PIC, F8FUL, and F87PHEN), were photochemically synthesized, and their electronic spectra were investigated to reveal the effects of the fluorination on the electronic features of phenacene molecules. F8-Phenacenes were conveniently synthesized by the Mallory photoreaction of the corresponding fluorinated diarylethenes as the key step. Upon fluorination on the phenacene cores, the absorption and fluorescence bands of the F8-phenacenes in CHCl3 systematically red-shifted by ca. 3-5 nm compared to those of the corresponding parent phenacenes. The vibrational progressions of the absorption and fluorescence bands were little affected by the fluorination in the solution phase. In the solid state, the absorption band of F8-phenacenes appeared in the similar wavelength region for the corresponding parent phenacenes whereas their fluorescence bands markedly red-shifted and broadened. These observations suggest that the intermolecular interactions of excited-state F8-phenacene molecules are significantly different from those of the corresponding parent molecules, most likely due to different crystalline packing motifs. en-copyright= kn-copyright= en-aut-name=IshiiYuuki en-aut-sei=Ishii en-aut-mei=Yuuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamajiMinoru en-aut-sei=Yamaji en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TaniFumito en-aut-sei=Tani en-aut-mei=Fumito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GotoKenta en-aut-sei=Goto en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KubozonoYoshihiro en-aut-sei=Kubozono en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Molecular Science, Graduate School of Science and Engineering, Gunma University kn-affil= affil-num=3 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=4 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=5 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=fluorescence kn-keyword=fluorescence en-keyword=fluorinated aromatics kn-keyword=fluorinated aromatics en-keyword=phenacene kn-keyword=phenacene en-keyword=photoreaction kn-keyword=photoreaction END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue= article-no= start-page=101 end-page=112 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=19891115 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Some Sketches of Social Networks in Canberra kn-title=ƒLƒƒƒ“ƒxƒ‰‚̎Љï“Iƒlƒbƒgƒ[ƒN‚ɂ‚¢‚Ä \\ŽQ—^ŠÏŽ@‚Ì‹L˜^\\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NOBEMASAO en-aut-sei=NOBE en-aut-mei=MASAO kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=83 cd-vols= no-issue= article-no= start-page=155 end-page=164 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=19900315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Stages of Development in Canberra\PART I kn-title=ƒLƒƒƒ“ƒxƒ‰‚É‚¨‚¯‚éŠJ”­‚Ì”’iŠKi‡Tj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NOBEMASAO en-aut-sei=NOBE en-aut-mei=MASAO kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=84 cd-vols= no-issue= article-no= start-page=165 end-page=177 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=19900716 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Stages of Development in Canberra\Part II kn-title=ƒLƒƒƒ“ƒxƒ‰‚É‚¨‚¯‚éŠJ”­‚Ì”’iŠKi‡Uj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NOBEMASAO en-aut-sei=NOBE en-aut-mei=MASAO kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue= article-no= start-page=63 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=19910715 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Daily Social Support among Canberra Residents kn-title=“úí¶Šˆ‚É‚¨‚¯‚鉇•Šó‹s“® \ƒLƒƒƒ“ƒxƒ‰‚ÌŽ–—á\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@This paper reports a study that investigated perceived sources of daily support. To gather empirical evidence, a sample survey of women in four study areas of Canberra was conducted in 1986-1987. Three hundred and ninety-four women who were under 55 years of age and who were married or in a de facto relationship were interviewed. They responded to six hypothetical difficult situations by identifying the first source from which they would seek support. Analysis of the data has revealed the following ;
@(1) When respondents had their relatives in Canberra, they regarded their relatives as the chief source of daily support. However, there were many residents without local relatives in Canberra. For such respondents, their relatives were not so helpful in daily support. Incidentally, workmates were thought of as much less important providers of support than relatives, neighbours or friends.
@(2) Social networks were differentiated in that respondents tended to depend on types of people appropriate to individual difficult situations.
@(3) Dependable friends and workmates tended to live closer than dependable relatives.
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en-title=An Analysis of the Function of g1GjaŒRh in the Tangut Military System \Positions of g1GjaŒRh and its Relationship with g1T?juEh\ kn-title=¼‰ÄŒR§‚É‚¨‚¯‚éuŒRv‚Ì‹@”\ \uŒRv‚É‘®‚·‚é’nˆÊ–¼Ì‚¨‚æ‚ÑuEv‚Æ‚ÌŠÖŒW\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ONOHiroko en-aut-sei=ONO en-aut-mei=Hiroko kn-aut-name=¬–ì—TŽq kn-aut-sei=¬–ì kn-aut-mei=—TŽq aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=123 end-page=141 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Punishment of Government Officials in the Qin and Han Periods \Focusing on thegFeih andgMianh \ kn-title=`Š¿Žž‘ã‚É‚¨‚¯‚銯—™‚̈”± \uœEv‚Æu–Æv‚ð’†S‚É\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=LIUCong en-aut-sei=LIU 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en-subject= kn-subject= en-title=Regional Response to Securing Transportation through Mutual Assistance \A Case Study of Okayama Prefecture\ kn-title=‹¤•‚É‚æ‚éŒð’ÊŽè’i‚ÌŠm•Û‚ÉŒW‚é’nˆæ“I‘Ήž \‰ªŽRŒ§“à‚ð—á‚É\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KATAOKAKatsumi en-aut-sei=KATAOKA en-aut-mei=Katsumi kn-aut-name=•Ð‰ªŽ–¤ kn-aut-sei=•Ð‰ª kn-aut-mei=Ž–¤ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=45 end-page=64 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Reconsideration of Vocabulary Difficulty Standards in "Easy Japanese": From the subdivision of polysemous words by J-CLID kn-title=u‚₳‚µ‚¢“ú–{Œêv‚É‚¨‚¯‚éŒêœb“ïˆÕ“xŠî€‚ÌÄŒŸ“¢ \J-CLID‚É‚æ‚鑽‹`Œê‚Ìוª—Þ‚©‚ç\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=LUJianhui en-aut-sei=LU en-aut-mei=Jianhui kn-aut-name=˜CŒš‹P kn-aut-sei=˜C kn-aut-mei=Œš‹P aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=25 end-page=44 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on the Relationship between Kazuo Inamori's Philosophy, the Teachings of Nanshu Saigo, and the Iroha Poem by Prince Jisshin kn-title=ˆî·˜a•v‚̃tƒBƒƒ\ƒtƒB[‚Ƽ‹½“ìF‰¥ˆâŒP‹y‚Ñ“úVŒö‚¢‚ë‚͉̘̂AŠÖ‚ɂ‚¢‚Ä‚ÌlŽ@ en-subtitle= kn-subtitle= en-abstract=Kazuo Inamori is a rare business leader who founded DDI, the predecessor of Kyocera and KDDI, in one generation, and grew it into a trillion-yen company. He also rebuilt the bankrupt Japan Airlines (JAL) in three years and led it to relisting. He has not only led tens of thousands of people with his unique management method called amoeba management, but also with management principles. What are the roots of the way of life that a manager of a small and medium-sized business has derived from management? What is the Goju education that is the foundation of Satsuma, where he was born and raised? From the perspective of business management, it is interesting to know what it is like.
How is it related to Saigo Nanshu Ikun, the record of the words and deeds of Saigo Takamori, a local hero whom Kazuo Inamori met after founding Kyocera and used as the basis of his own management philosophy, and Shimazu Nisshin Iroha Uta, left by Shimazu Tadayoshi (Nissin), the father of Shimazu Takahisa, the 15th lord of the Shimazu clan who unified southern Kyushu, including Satsuma and Hyuga, in the 16th century? First of all, I am interested in the relationship between the ideas of the three men born in Satsuma. In this study, we used the grounded theory approach, a qualitative research method, to analyze the correlation between Kazuo Inamori's philosophy, the teachings of Nanshu Saigo, and the Nisshin Iroha Uta. As a result, the analysis revealed that the three concepts are related across 400 years of time. In particular, Kazuo Inamori's philosophy is not only positively influenced by the teachings of Nanshu Saigo, which are the words and deeds of Takamori Saigo, whom Kazuo Inamori admires, but also by the Nisshin Iroha Uta, which dates back 400 years, due to his education in Satsuma. It is believed that the ideals that the people of Satsuma have inherited for 400 years contain concepts that should be the foundation for people's lives, or that should be important core ideas and qualities in life, regardless of the era. kn-abstract=@ˆê‘ã‚Å‹žƒZƒ‰‚âKDDI‚Ì‘Og‚Æ‚È‚é‘æ“ñ“d“diDDIj‚ð‘n‹Æ‚µA‡Œv”’›‰~Šé‹Æ‚Ɉç‚ÄA“|ŽY‚µ‚½“ú–{q‹óiJALj‚ð3”N‚ÅÄŒš‚µAÄãê‚É“±‚¢‚½‹H‘ã‚ÌŒo‰cŽÒˆî·˜a•v‚ÍAƒAƒ[ƒoŒo‰c‚Æ‚¢‚¤“ÆŽ©‚ÌŒo‰cŽè–@‚¾‚¯‚Å‚È‚­A—”OŒo‰c‚É‚æ‚è”–œl‚𓱂¢‚Ä‚«‚½B’†¬Šé‹Æ‚̈êŒo‰cŽÒ‚ªŒo‰c‚Ì’†‚©‚瓱‚«o‚µ‚½l¶¬Œ÷‚̈¢p‚̃‹[ƒc‚͉½ˆ‚É‚ ‚é‚Ì‚©B¶‚Ü‚êˆç‚Á‚½ŽF–€‚ÌŠî‘b‚ƂȂ鋽’†i‚²‚¶‚イj‹³ˆç‚Ƃ͉½‚©A‚Ȃǂɂ‚¢‚ÄŒo‰cŠw‚ÌŠÏ“_‚©‚çŠÖS‚ª—N‚­B
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affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ en-keyword=ˆî·˜a•v (Kazuo Inamori) kn-keyword=ˆî·˜a•v (Kazuo Inamori) en-keyword=ƒtƒBƒƒ\ƒtƒB[ (philosophy) kn-keyword=ƒtƒBƒƒ\ƒtƒB[ (philosophy) en-keyword=¼‹½—²· (Takamori Saigo) kn-keyword=¼‹½—²· (Takamori Saigo) en-keyword=¼‹½“ìF‰¥ˆâŒP (the teachings of Nanshu Saigo) kn-keyword=¼‹½“ìF‰¥ˆâŒP (the teachings of Nanshu Saigo) en-keyword=“‡’Ã’‰—Çi“úVj (Tadayoshi Shimazu (Nissin)) kn-keyword=“‡’Ã’‰—Çi“úVj (Tadayoshi Shimazu (Nissin)) en-keyword=“úVŒö‚¢‚ë‚Í‰Ì (Nisshin Iroha Uta) kn-keyword=“úVŒö‚¢‚ë‚Í‰Ì (Nisshin Iroha Uta) en-keyword=ƒOƒ‰ƒEƒ“ƒfƒbƒhEƒZƒIƒŠ[EƒAƒvƒ[ƒ` (grounded theory approach) kn-keyword=ƒOƒ‰ƒEƒ“ƒfƒbƒhEƒZƒIƒŠ[EƒAƒvƒ[ƒ` (grounded theory approach) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=15 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=iTranslationjkatrina Jaworski : The Gender of 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dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=sŽ„‚Ì‘Œê‹³ŽºtV‚µ‚¢u‘ŽÊ‘“¹vŽö‹Æ‚Ì‚ ‚è•û \“‚‘ã‚Ìu–@v‚©‚ç‘v‘ã‚ÌuˆÓv‚ւ̃Vƒtƒg‚ð‘‹}‚É\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‘O“cG—Y kn-aut-sei=‘O“c kn-aut-mei=G—Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue= article-no= start-page=(1) end-page=(16) dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ûüŠKžXˆêu•—‚ÌŒÜü•ˆv‚̉ðŽß \”­‰¹‚©‚玂Ì\‘¢‚ð“ǂ݉ð‚­\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=–”‹g—¢”ü kn-aut-sei=–”‹g kn-aut-mei=—¢”ü aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue= article-no= start-page=15 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=sŽ„‚Ì‘Œê‹³Žºt’nˆæ‚Ì–£—Í‚ªŠw‚ÔˆÓ—~‚ðŠ«‹N‚·‚é en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=’†‰Í•‘ kn-aut-sei=’†‰Í kn-aut-mei=•‘ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Q‰®ìŽs—§‘æŽO’†ŠwZ END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue= article-no= start-page=1 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=–ÚŽw‚·Žq‹Ÿ‘œ‚̉ðŽß‚ð’Ê‚¶‚½‘Œê‰È‚ÌŽö‹Æ‰ü‘P \ƒJƒŠƒLƒ…ƒ‰ƒ€ŠJ”­‚𑣂·‹³Žt‚Ì–ðŠ„‚É’…–Ú‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ˆî–{‘½‰ÁŽu kn-aut-sei=ˆî–{ kn-aut-mei=‘½‰ÁŽu aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw•‘®¬ŠwZ END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž† en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue= article-no= start-page=1551700 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250305 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Acetoacetate, a ketone body, attenuates neuronal bursts in acutely-induced epileptiform slices of the mouse hippocampus en-subtitle= kn-subtitle= en-abstract= kn-abstract=The ketogenic diet increases ketone bodies (beta-hydroxybutyrate and acetoacetate) in the brain, and ameliorates epileptic seizures in vivo. However, ketone bodies exert weak or no effects on electrical activity in rodent hippocampal slices. Especially, it remains unclear what kinds of conditions are required to strengthen the actions of ketone bodies in hippocampal slices. In the present study, we examined the effects of acetoacetate on hippocampal pyramidal cells in normal slices and epileptiform slices of mice. By using patch-clamp recordings from CA1 pyramidal cells, we first confirmed that acetoacetate did not change the membrane potentials and intrinsic properties of pyramidal cells in normal slices. However, we found that acetoacetate weakened spontaneous epileptiform bursts in pyramidal cells of epileptiform slices, which were acutely induced by applying convulsants to normal slices. Interestingly, acetoacetate did not change the frequency of the epileptiform bursts, but attenuated individual epileptiform bursts. We finally examined the effects of acetoacetate on excitatory synaptic barrages during epileptiform activity, and found that acetoacetate weakened epileptiform bursts by reducing synchronous synaptic inputs. These results show that acetoacetate attenuated neuronal bursts in epileptiform slices, but did not affect neuronal activity in normal slices, which leads to seizure-selective actions of ketone bodies. en-copyright= kn-copyright= en-aut-name=WenHao en-aut-sei=Wen en-aut-mei=Hao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SadaNagisa en-aut-sei=Sada en-aut-mei=Nagisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InoueTsuyoshi en-aut-sei=Inoue en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Biophysical Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Biophysical Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Biophysical Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=epilepsy kn-keyword=epilepsy en-keyword=ketone body kn-keyword=ketone body en-keyword=ketogenic diet kn-keyword=ketogenic diet en-keyword=hippocampus kn-keyword=hippocampus en-keyword=slice physiology kn-keyword=slice physiology en-keyword=patch-clamp recording kn-keyword=patch-clamp recording END start-ver=1.4 cd-journal=joma no-vol=121 cd-vols= no-issue= article-no= start-page=207 end-page=214 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20021115 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Basic Characteristics of Personal Networks of Elderly Women in a Small Japanese City kn-title=ƒƒ‹ƒ{ƒ‹ƒ“‚ÌZ–¯‚Ì•é‚炵 ˆêŽQ—^ŠÏŽ@‚É‚æ‚錤‹†ˆê en-subtitle= kn-subtitle= en-abstract= kn-abstract=@ƒƒ‹ƒ{ƒ‹ƒ“‚ÉZ‚ÞƒI[ƒXƒgƒ‰ƒŠƒAl‚̉ƒë‚Ńz[ƒ€ƒXƒeƒC‚ð‚¨‚±‚È‚¢C‚»‚̉Ƒ°¶Šˆ‚âŒðÛ‚ðŽQ—^ŠÏŽ@‚µ‚½B‚»‚µ‚ÄCŽŸ‚Ì2“_‚𖾂炩‚É‚µ‚½B‡@ƒƒ‹ƒ{ƒ‹ƒ“‚Å‚ÍC‘ål‚Í1‘䂸‚ÂŽÔ‚ðŽ‚‚±‚Æ‚ªˆê”Ê“I‚É‚È‚Á‚Ä‚«‚½BŠOo‚É‚Í‚½‚¢‚Ä‚¢ŽÔ‚ðŽg‚¢C‹ßŠ‚ð•à‚­‚±‚Æ‚ª­‚È‚­‚È‚Á‚½‚©‚çC‹ßŠ‚ÌlX‚Æ’m‚臂¢‚É‚È‚è‚É‚­‚­‚È‚Á‚½B‚»‚±‚ÅC‹ß—׊֌W‚â‹ß—׌ðÛ‚ª–R‚µ‚­‚È‚èC‹ßŠ‚ÌlX‚Æ•‚¯‚ ‚¤‚±‚Æ‚à‚ ‚Ü‚è‚È‚­‚È‚Á‚½B‡AŽÔ‚ðŽg‚Á‚ÄŠOo‚ð‚·‚é‚Ì‚ÅCŽ©—R‚És‚«—ˆ‚Å‚«‚é’n—“I”͈͂ªL‚­‚È‚Á‚½B‚»‚Ì‚½‚ßCZ–¯‚ÍL”͈͂ÉZ‚Þ‘½‚­‚ÌlX‚Ì’†‚©‚çC‹CS‚ª‚ ‚Á‚½‚èC—˜ŠQ‚âŠÖS‚ð‹¤—L‚·‚é‘ŠŽè‚ðŽ©—R‚É‘I‚ñ‚Å—FlŠÖŒW‚ðŽæ‚茋‚ÑC‚»‚¤‚µ‚½—Fl‚ÆŒð—V‚ð‚µ‚½‚èC¶Šˆ‚Ì•‚¯‡‚¢‚ð‚¨‚±‚È‚Á‚Ä‚¢‚éB en-copyright= kn-copyright= en-aut-name=NOBEMasao en-aut-sei=NOBE en-aut-mei=Masao kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Social Studies Education, Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆçŠw•”ŽÐ‰ï‰È‹³ˆçuÀ en-keyword=ƒƒ‹ƒ{ƒ‹ƒ“ kn-keyword=ƒƒ‹ƒ{ƒ‹ƒ“ en-keyword=ŽQ—^ŠÏŽ@ kn-keyword=ŽQ—^ŠÏŽ@ en-keyword=ƒp[ƒ\ƒiƒ‹Eƒlƒbƒgƒ[ƒN 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kn-title=‰ªŽRŽs‚É‚¨‚¯‚élŒû‚Ì’n—“IˆÚ“®‚Ì–¨•ªÍ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@‰ªŽRŽs‚ÍClŒû–ñ63–œl‚Ì’n•û’†Šj“sŽs‚Å‚ ‚éB–{e‚Å‚ÍC1965”NC1975”NC1985”NC1995”NC2000”N‚É‚¨‚¯‚éC‰ªŽRŽs‚̃f[ƒ^‚ðŒŸ“¢‚µClŒû‚Ì’n—“IˆÚ“®‚Ì–¨‚𖾂炩‚É‚µ‚½B‚³‚ç‚ÉC‰ªŽRŒ§‚Ì’n•û¬“sŽs‚Å‚ ‚é‚—ÀŽs‚Ì’n—“IˆÚ“®‚Æ”äŠr‚ð‚¨‚±‚È‚Á‚½B en-copyright= kn-copyright= en-aut-name=NOBEMasao en-aut-sei=NOBE en-aut-mei=Masao kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Social Studies Education, Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆçŠw•”ŽÐ‰ï‰È‹³ˆçuÀ en-keyword=’n—“IˆÚ“® kn-keyword=’n—“IˆÚ“® en-keyword=“]“üE“]o kn-keyword=“]“üE“]o en-keyword=ƒˆÚ“®” kn-keyword=ƒˆÚ“®” en-keyword=‰ªŽRŽs kn-keyword=‰ªŽRŽs END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue= article-no= start-page=107 end-page=110 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Research Note on Aged Care Services in Melbourne kn-title=ƒƒ‹ƒ{ƒ‹ƒ“‚É‚¨‚¯‚é‚—îŽÒ‚ւ̃PƒAEƒT[ƒrƒX‚ƉîŒìƒT[ƒrƒX en-subtitle= kn-subtitle= en-abstract= kn-abstract=@•MŽÒ‚̓ƒ‹ƒ{ƒ‹ƒ“‘å“sŽsŒ—‚É‚ ‚éƒzƒƒCƒgƒz[ƒXŽs‚ÅŽs–ðŠ‚Ì•ŸŽƒ’S“–ŽÒ‚⋳‰ï‚ª‰^‰c‚·‚éƒi[ƒVƒ“ƒOEƒz[ƒ€‚ð–K–₵C‚—îŽÒ‚ւ̃PƒAEƒT[ƒrƒX‚â‰îŒìƒT[ƒrƒX‚ÉŠÖ‚µ‚Ä‚Ì•·‚«Žæ‚è’²¸‚⎑—¿ŽûW‚ð‚¨‚±‚È‚Á‚½B–{e‚Å‚ÍC‚»‚Ì•·‚«Žæ‚è’²¸‚âŽûW‚µ‚½Ž‘—¿‚É‚à‚Ƃ¢‚ÄC“¯Žs‚É‚¨‚¯‚éƒPƒAEƒT[ƒrƒX‚ƉîŒìƒT[ƒrƒX‚ÌŒ»ó‚ðЉ‚½B en-copyright= kn-copyright= en-aut-name=NOBEMasao en-aut-sei=NOBE en-aut-mei=Masao kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Social Studies Education, Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆçŠw•”ŽÐ‰ï‰È‹³ˆçuÀ en-keyword=ƒLƒƒ‹ƒ{ƒ‹ƒ“ kn-keyword=ƒLƒƒ‹ƒ{ƒ‹ƒ“ en-keyword=‚—îŽÒ kn-keyword=‚—îŽÒ en-keyword=ƒPƒAEƒT[ƒrƒX kn-keyword=ƒPƒAEƒT[ƒrƒX en-keyword=‰îŒìƒT[ƒrƒX kn-keyword=‰îŒìƒT[ƒrƒX END start-ver=1.4 cd-journal=joma no-vol=85 cd-vols= no-issue=6 article-no= start-page=1082 end-page=1096 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Myeloid Cells Induce Infiltration and Activation of B Cells and CD4+ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy en-subtitle= kn-subtitle= en-abstract= kn-abstract=Brain metastasis is a poor prognostic factor in patients with cancer. Despite showing efficacy in many extracranial tumors, immunotherapy with anti?PD-1 mAb or anti?CTLA4 mAb seems to be less effective against intracranial tumors. Promisingly, recent clinical studies have reported that combination therapy with anti?PD-1 and anti?CTLA4 mAbs has a potent antitumor effect on brain metastasis, highlighting the need to elucidate the detailed mechanisms controlling the intracranial tumor microenvironment (TME) to develop effective immunotherapeutic strategies. In this study, we analyzed the tumor-infiltrating lymphocytes in murine models of brain metastasis that responded to anti?CTLA4 and anti?PD-1 mAbs. Activated CD4+ T follicular helper (TFH) cells with high CTLA4 expression characteristically infiltrated the intracranial TME, which were activated by combination anti?CTLA4 and anti?PD-1 treatment. The loss of TFH cells suppressed the additive effect of CTLA4 blockade on anti?PD-1 mAb. B-cell?activating factor belonging to the TNF family (BAFF) and a proliferation-inducing ligand (APRIL) produced by abundant myeloid cells, particularly CD80hiCD206lo proinflammatory M1-like macrophages, in the intracranial TME induced B-cell and TFH-cell infiltration and activation. Furthermore, the intracranial TME of patients with non?small cell lung cancer featured TFH- and B-cell infiltration as tertiary lymphoid structures. Together, these findings provide insights into the immune cell cross-talk in the intracranial TME that facilitates an additive antitumor effect of CTLA4 blockade with anti?PD-1 treatment, supporting the potential of a combination immunotherapeutic strategy for brain metastases.
Significance: B-cell and CD4+ T follicular helper cell activation via BAFF/APRIL from abundant myeloid cells in the intracranial tumor microenvironment enables a combinatorial effect of CTLA4 and PD-1 blockade in brain metastases. en-copyright= kn-copyright= en-aut-name=NinomiyaToshifumi en-aut-sei=Ninomiya en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KemmotsuNaoya en-aut-sei=Kemmotsu en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MukoharaFumiaki en-aut-sei=Mukohara en-aut-mei=Fumiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MagariMasaki en-aut-sei=Magari en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyamotoAi en-aut-sei=Miyamoto en-aut-mei=Ai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UedaYouki en-aut-sei=Ueda en-aut-mei=Youki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IshinoTakamasa en-aut-sei=Ishino en-aut-mei=Takamasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NagasakiJoji en-aut-sei=Nagasaki en-aut-mei=Joji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FujiwaraTomohiro en-aut-sei=Fujiwara en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamamotoHidetaka en-aut-sei=Yamamoto en-aut-mei=Hidetaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=HayashiHidetoshi en-aut-sei=Hayashi en-aut-mei=Hidetoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=TachibanaKota en-aut-sei=Tachibana en-aut-mei=Kota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=IshidaJoji en-aut-sei=Ishida en-aut-mei=Joji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=OtaniYoshihiro en-aut-sei=Otani en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=TanakaShota en-aut-sei=Tanaka en-aut-mei=Shota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=OkamotoIsamu en-aut-sei=Okamoto en-aut-mei=Isamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=TogashiYosuke en-aut-sei=Togashi en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= affil-num=1 en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=5 en-affil=Medical Protein Engineering, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=6 en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Orthopaedic Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Pathology and Oncology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=11 en-affil=Department of Medical Oncology, Kindai University Faculty of Medicine kn-affil= affil-num=12 en-affil=Department of Dermatology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=13 en-affil=Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=14 en-affil=Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=15 en-affil=Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=16 en-affil=Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Science, Okayama University kn-affil= affil-num=17 en-affil=Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University kn-affil= affil-num=18 en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=— •\Ž†E‰p•¶–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰œ•t en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰ªŽR‘åŠw‹³Žt‹³ˆçŠJ”­ƒZƒ“ƒ^[‹I—vŒ´eŽ·•M—v—Ì en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰ªŽR‘åŠw‹³Žt‹³ˆçŠJ”­ƒZƒ“ƒ^[‚ÌŠˆ“®ó‹µ‚ÌŠT—v en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=357 end-page=371 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Proposals for Supporting Childrenfs Adaptation in School Mergers and Closures kn-title=ŠwZ“”p‡‚É‚¨‚¯‚鎙“¶‚Ì“K‰žŽx‰‡ô‚Ì’ñŒ¾ en-subtitle= kn-subtitle= en-abstract=The purpose of this study is to examine the impact of school mergers and closures on children through a literature review and field survey and to propose strategies for supporting children's adaptation to the resulting environmental transitions. First, a literature review on school mergers and closures indicated that such experiences could influence children's later interpersonal relationships and increase stress responses. However, research on the impact of school mergers and closures on children remains limited, with insufficient understanding of their psychological effects on children. Next, interviews conducted as part of a field survey revealed that school mergers and closures could be significant sources of stress for children. Based on these findings, we recommends multi-level support measures targeting individuals, classes, grades, and entire schools, primarily through special activities, to help mitigate the impact of these transitions on children. kn-abstract=–{Œ¤‹†‚Ì–Ú“I‚ÍCŠwZ“”p‡‚ÉŒW‚镶Œ£ŒŸõ‚¨‚æ‚ÑŽÀ‘Ô’²¸‚ð’Ê‚µ‚ÄCŠwZ“”p‡‚Æ‚¢‚¤ŠÂ‹«ˆÚs‚ªŽ™“¶‚É—^‚¦‚é‰e‹¿‚ɂ‚¢‚ÄŒŸ“¢‚µCŠwZ“”p‡‚ª‚à‚½‚ç‚·ŠÂ‹«ˆÚs‚ɑ΂·‚鎙“¶‚Ì“K‰žŽx‰‡ô‚ɂ‚¢‚Ä’ñŒ¾‚·‚邱‚Æ‚Å‚ ‚éB‚Ü‚¸CŠwZ“”p‡‚ÉŒW‚镶Œ£ŒŸõ‚ðs‚Á‚½Œ‹‰ÊCŠwZ“”p‡‚ÌŒoŒ±‚ªŽ™“¶¶“k‚Ì‚»‚ÌŒã‚ÌlŠÔŠÖŒWŒ`¬‚âƒXƒgƒŒƒX”½‰ž‚Ì‘‰Á‚ɉe‹¿‚ð—^‚¦‚Ä‚¢‚é‰Â”\«‚ªŽ¦‚³‚ꂽB‚µ‚©‚µCŠwZ“”p‡‚ªŽ™“¶‚É—^‚¦‚é‰e‹¿‚ÉŠÖ‚·‚錤‹†‚Í”ñí‚É­‚È‚­C“”p‡‚ÌŒoŒ±‚ªŽ™“¶‚É—^‚¦‚éS—“I‰e‹¿‚ɂ‚¢‚Ä‚Í\•ª‚ɉ𖾂³‚ê‚Ä‚¢‚È‚¢‚±‚Æ‚ª‚í‚©‚Á‚½BŽŸ‚ÉCŽÀ‘Ô’²¸‚Æ‚µ‚Äs‚Á‚½ƒCƒ“ƒ^ƒrƒ…[‚É‚¨‚¢‚ÄCŠwZ“”p‡‚ªŽ™“¶‚É‚Æ‚Á‚Ä‘å‚«‚ȃXƒgƒŒƒX—vˆö‚Æ‚È‚é‰Â”\«‚ª‚ ‚邱‚Æ‚ª‚í‚©‚Á‚½B‚±‚ê‚ç‚ÌŒ»ó‚𓥂܂¦‚ÄCŠwZ“”p‡‚ªŽ™“¶‚É—^‚¦‚é‰e‹¿‚ð˜a‚ç‚°‚邽‚ßC“Á•ÊŠˆ“®‚ð’†S‚Æ‚µ‚ÄCŒÂlEŠw‹‰EŠw”NEŠwZƒŒƒxƒ‹‚Å‚Ì‹ï‘Ì“I‚ÈŽæ‘g‚ð’ñˆÄ‚µ‚½B en-copyright= kn-copyright= en-aut-name=IKEDAYuka en-aut-sei=IKEDA en-aut-mei=Yuka kn-aut-name=’r“c?‰Á kn-aut-sei=’r“c kn-aut-mei=?‰Á aut-affil-num=1 ORCID= en-aut-name=IZUMITsuguyuki en-aut-sei=IZUMI en-aut-mei=Tsuguyuki kn-aut-name=ˆÉZŒps kn-aut-sei=ˆÉZ kn-aut-mei=Œps aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Education (Professional Degree Corse), Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@¶ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=ŠwZ“”p‡ (School Consolidation) kn-keyword=ŠwZ“”p‡ (School Consolidation) en-keyword=Ž™“¶ (Children) kn-keyword=Ž™“¶ (Children) en-keyword=lŠÔŠÖŒWŒ`¬ (Relationship Building) kn-keyword=lŠÔŠÖŒWŒ`¬ (Relationship Building) en-keyword=ƒXƒgƒŒƒX (Stress) kn-keyword=ƒXƒgƒŒƒX (Stress) en-keyword=“Á•ÊŠˆ“® (Special Activities) kn-keyword=“Á•ÊŠˆ“® (Special Activities) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=341 end-page=355 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Research Trends on Educational Needs and Support of Children with Cancer kn-title=¬Ž™‚ª‚ñŠ³Ž™‚ɑ΂·‚鋳ˆç“IŽx‰‡‚Æ‚»‚ÌŒ¤‹†“®Œü en-subtitle= kn-subtitle= en-abstract=@In this study, we summarized research trends related to the educational needs and support of children with cancer from the perspectives of glearning,h gself-management,h ginterpersonal,h gpsychological,h and gcollaboration,h. In terms of learning, the study showed that experiential learning and distance education are solutions to the problem of delayed learning due to prolonged absence from school and poor concentration during treatment. Next, in self-management, it is important to educate affected children so that they can fully understand the disease and treatment. In addition, in terms of interpersonal support, it is difficult for the affected patients to build relationships with friends, but providing opportunities for interaction is expected to contribute to the improvement of interpersonal relationships. In terms of psychological support, the anxiety associated with treatment is a major psychological burden for the affected children, and the understanding of their friends and the intervention of university student volunteers are effective in helping them achieve psychological stability. Finally, the lack of cooperation between medical institutions and schools was highlighted as a deficiency in the support system, which needs to be strengthened. In the future, these support measures should be empirically verified to establish a sustainable support system. kn-abstract=@–{Œ¤‹†‚ÍA¬Ž™‚ª‚ñŠ³Ž™‚Ì‹³ˆç“IŽx‰‡‚ÉŠÖ‚·‚錤‹†‚Ì“®Œü‚𖾂炩‚É‚µA¡Œã‚̉ۑè‚Æ‚»‚̉ðŒˆô‚ð’ñ‹N‚·‚邱‚Æ‚ð–Ú“I‚Æ‚µ‚½BuŠwKvAuŽ©ŒÈŠÇ—vAu‘ÎlvAuS—vAu˜AŒgv‚Ì5‚‚̎‹“_‚©‚番͂ðs‚Á‚½BŠwKŽx‰‡‚ɂ‚¢‚ÄAŽ¡—Âɔº‚¤ŠwK‚Ì’x‚ê‚âW’†—͂̒ቺ‚ɑ΂µAŒÂ•Ê‚Ì‹³ˆçŽx‰‡Œv‰æ‚â‘ÌŒ±“I‚ÈŠwKA‚¨‚æ‚щ“Šu‹³ˆç‚ÌŽÀŽ{‚ÉŠú‘Ò‚³‚ê‚Ä‚¢‚½BŽ©ŒÈŠÇ—Žx‰‡‚Å‚ÍAŠ³Ž™‚ªŽ©g‚Ì•aó‚⎡—Âɂæ‚é•›ì—p‚ð—‰ð‚µAŽ©—§“I‚ÉŠÇ—‚Å‚«‚é”\—Í‚ðˆç¬‚·‚邱‚Æ‚ª‹‚ß‚ç‚ê‚Ä‚¢‚½B‘ÎlŽx‰‡‚ɂ‚¢‚ÄAŠ³Ž™‚Ì’·Šú“ü‰@‚É‚æ‚èA—FlŠÖŒW‚Ì\’z‚ª¢“ï‚É‚È‚èA“ü‰@’†‚â•œŠwŒã‚̃Rƒ~ƒ…ƒjƒP[ƒVƒ‡ƒ“‚ÌŽx‰‡‚ªd—v‚Å‚ ‚邱‚Æ‚ªŠm”F‚³‚ꂽBS—Žx‰‡‚É‚¨‚¢‚Ä‚ÍAŽüˆÍ‚Ö‚ÌŒø‰Ê“I‚È‚ª‚ñ‹³ˆç‚â‘åŠw¶ƒ{ƒ‰ƒ“ƒeƒBƒA‚É‚æ‚éŽx‰‡‚ªAŠ³Ž™‚ÌS—“IˆÀ’è‚𑣂·‚±‚Æ‚ªŽ¦‚³‚ꂽBÅŒã‚ÉAŠwZ‚ƈã—Ë@ŠÖA•ÛŒìŽÒ‚̘AŒg•s‘«‚ªŽw“E‚³‚ê‚Ä‚¨‚èA˜AŒgƒc[ƒ‹‚ÌŠJ”­‚ª‹‚ß‚ç‚ê‚Ä‚¢‚éB en-copyright= kn-copyright= en-aut-name=CHENYiwen en-aut-sei=CHEN en-aut-mei=Yiwen kn-aut-name=’ˆ˕¶ kn-aut-sei=’ kn-aut-mei=ˆË•¶ aut-affil-num=1 ORCID= en-aut-name=YOSHITOSHIMunehisa en-aut-sei=YOSHITOSHI en-aut-mei=Munehisa kn-aut-name=‹g—˜@‹v kn-aut-sei=‹g—˜ kn-aut-mei=@‹v aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Education Doctoral Programs, Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@˜A‡ŠwZ‹³ˆçŠwŒ¤‹†‰È”ŽŽm‰Û’ö affil-num=2 en-affil=Graduate School of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=¬Ž™‚ª‚ñ (child hood cancer) kn-keyword=¬Ž™‚ª‚ñ (child hood cancer) en-keyword=–«Ž¾Š³ (chronic illness) kn-keyword=–«Ž¾Š³ (chronic illness) en-keyword=‹³ˆç“Iƒj[ƒY (educational needs) kn-keyword=‹³ˆç“Iƒj[ƒY (educational needs) en-keyword=Œ¤‹†“®Œü (research trends) kn-keyword=Œ¤‹†“®Œü (research trends) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=325 end-page=339 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Recommendations on how to View STEAM Education in General Education and Development of Classes and Teacher Training ?Through the Enrichment of Integrated Inquiry Time? kn-title=•’ʉȂɂ¨‚¯‚é STEAM ‹³ˆç‚Ì‘¨‚¦•û‚Ì’ñŒ¾‚ÆŽö‹Æ‚¨‚æ‚Ñ‹³ˆõŒ¤C‚ÌŠJ”­@\‘‡“I‚È’T‹†‚ÌŽžŠÔ‚Ì[ŽÀ‚ð’Ê‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–{ŽÀ‘H•ñ‚Å‚ÍC•’ʉȂɂ¨‚¯‚é STEAM ‹³ˆç‚Ì‘¨‚¦•û‚ð’ñŒ¾‚µC‹ï‘Ì“I‚ÈŽö‹ÆŽÀ‘H‚⋳ˆõŒ¤C‚ð’ñˆÄ‚·‚éBæsŒ¤‹†“™‚Å‹c˜_‚³‚ê‚Ä‚¢‚é STEAM ‹³ˆç‚ÌŠT”O“™‚©‚çCSTEAM ‹³ˆç‚̪Š²‚Í‘n‘¢«‚🼗{EŽhŒƒE”­Šö‚·‚鋳ˆç‚Å‚ ‚é‚Æ‘¨‚¦CSTEAM ‹³ˆç‚ÆÅ‚àe˜a«‚ª‚‚¢‘‡“I‚È’T‹†‚ÌŽžŠÔ‚ÅŽö‹ÆŽÀ‘H‚ðs‚Á‚½BŽæ‚è‘g‚Ý‚ÌŒø‰Ê‚ɂ‚¢‚Ä‚ÍC¬‰Ê•¨‚Ì•ªÍ‚âƒqƒAƒŠƒ“ƒO’²¸“™‚ð’Ê‚µ‚ÄŒŸØ‚µC’T‹†‚ðŽ©•ªŽ–‚É‚Å‚«‚Ä‚¢‚邱‚Æ‚ªŽ¦´‚³‚ꂽB‚Ü‚½C¶“k‚ª‘n‘¢«‚🼗{EŽhŒƒE”­Šö‚·‚éê–Ê‚ÍCŠe‹³‰È“™‚ÌŽö‹Æ“à‚Å‚àŽÀŒ»‚Å‚«‚é‚Æl‚¦CuŠy‚µ‚­[‚Ü‚éŽö‹Æv‚ðƒe[ƒ}‚É‚µ‚½‹³ˆõŒ¤C‚ÌŠJ”­‚ðs‚Á‚½B‚±‚ÌŒ¤C‚Å‚ÍŽö‹ÆŠJ”­‚ð‹³ˆõ‚̃`[ƒ€’T‹†‚Æ‘¨‚¦C‘‡“I‚È’T‹†‚ÌŽžŠÔ‚Ŷ“k‚ªŽæ‚è‘g‚Þƒ[ƒN“™‚àŠˆ—p‚µ‚½B‘‡“I‚È’T‹†‚ÌŽžŠÔ‚ðŽó‚¯‚½ŒoŒ±‚Ì‚È‚¢‹³ˆõ‚ª’T‹†Šˆ“®‚̃vƒƒZƒX‚ðŒoŒ±‚µC’T‹†‚ÌŠy‚µ‚³‚⃃NƒƒNŠ´‚ðŽÀŠ´‚Å‚«‚邱‚Æ‚à‘_‚Á‚Ä‚¢‚éBŽå‘Ì“I‚ÅŠˆ”­‚È‘SZŒ¤C‚ªŽÀŒ»‚µC‹³ˆõ‚ª’T‹†“I‚ÉŽö‹Æ‘n‚è‚ði‚߂邱‚Æ‚Ì‚Å‚«‚錤C‚ÌŽdŠ|‚¯‚ðŒ©o‚·‚±‚Æ‚ª‚Å‚«‚½B en-copyright= kn-copyright= en-aut-name=EBARAMitsuo en-aut-sei=EBARA en-aut-mei=Mitsuo kn-aut-name=]Œ´Œõ•v kn-aut-sei=]Œ´ kn-aut-mei=Œõ•v aut-affil-num=1 ORCID= en-aut-name=INADAYoshihiko en-aut-sei=INADA en-aut-mei=Yoshihiko kn-aut-name=ˆî“c‰À•F kn-aut-sei=ˆî“c kn-aut-mei=‰À•F aut-affil-num=2 ORCID= affil-num=1 en-affil=Okayama Prefectural Kurashiki Amaki High School (Graduate School of Education (Professional Degree Corse), Okayama University) kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@¶ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=STEAM ‹³ˆç (STEAM education) kn-keyword=STEAM ‹³ˆç (STEAM education) en-keyword=‘n‘¢« (creativity) kn-keyword=‘n‘¢« (creativity) en-keyword=‘‡“I‚È’T‹†‚ÌŽžŠÔ (integrated inquiry time) kn-keyword=‘‡“I‚È’T‹†‚ÌŽžŠÔ (integrated inquiry time) en-keyword=•’Ê‰È (general education) kn-keyword=•’Ê‰È (general education) en-keyword=‹³ˆõŒ¤C (teacher training) kn-keyword=‹³ˆõŒ¤C (teacher training) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=313 end-page=324 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An Attempt at International Understanding Education Incorporating Letter Exchange Activities between Japanese and Chinese High School Students: Through Development of a Civics Unit Plan on International Issues kn-title=“ú’†‚Ì‚Z¶‚̎莆‚ðŽg‚Á‚½Œð—¬Šˆ“®‚ðŽæ‚è“ü‚ꂽ‘Û—‰ð‹³ˆç‚ÌŽŽ‚Ý@\‘Û“I‰Û‘è‚ðŽæ‚èã‚°‚½Œö–¯‰È‚Ì’PŒ³ŠJ”­\ en-subtitle= kn-subtitle= en-abstract=This study reports the results of the development and practice of a class in which Japanese and Chinese high school students deepened mutual understanding and became aware of themselves as members of the international community through l earning activities in which they exchanged letters in order to share their thoughts on a global international issue. Through the practice, it became clear that exchange activities have the following significance for students. Firstly, it was the first one-on-one exchange with a foreigner. Even if they did not meet directly, for many of the students in this class, it was their first experience to interact with people from other countries. Secondly, it was an opportunity for them to develop an interest in other cultures and schools. Thirdly, the students were able to consider the issue of climate change from a global perspective. kn-abstract=@–{Œ¤‹†‚ÍC“ú–{‚Æ’†‘‚Ì‚Z¶‚ª’n‹…‹K–Í‚Ì‘Û“I‰Û‘è‚ɂ‚¢‚Äl‚¦‚ð‹¤—L‚·‚邽‚ß‚ÉCŽèŽ†‚ðŒðŠ·‚·‚éŠwKŠˆ“®‚ð’Ê‚µ‚Ä‘ŠŒÝ—‰ð‚ð[‚ßC‘ێЉï‚̈êˆõ‚Æ‚µ‚Ä‚ÌŽ©Šo‚ðŽ‚‚悤‚ɂȂ邱‚Æ‚ð–ÚŽw‚µ‚½Žö‹Æ‚ÌŠJ”­EŽÀ‘H‚̬‰Ê‚ð•ñ‚·‚é‚à‚Ì‚Å‚ ‚éBŽÀ‘H‚ð’Ê‚µ‚ÄCŒð—¬Šˆ“®‚Ͷ“k‚É‚Æ‚Á‚ÄŽŸ‚̂悤‚ȈӋ`‚ª‚ ‚邱‚Æ‚ª–¾‚ç‚©‚É‚È‚Á‚½B‘æ[‚ÍCŠO‘l‚Ƃ̉‚߂Ă̈ê‘Έê‚̌𗬂ł ‚Á‚½‚Æ‚¢‚¤‚±‚Æ‚Å‚ ‚éB’¼Ú‰ï‚í‚È‚¢Œ`‚Å‚ ‚Á‚½‚Æ‚µ‚Ä‚àC¡‰ñ‚ÌŽö‹Æ‚ðŽó‚¯‚½‘½‚­‚̶“k‚É‚Æ‚Á‚Ä‚Í‘¼‚Ì‘‚Ìl‚ÆŠÖ‚í‚鉂߂Ă̌oŒ±‚Å‚ ‚Á‚½B‘æ“ñ‚ÍC‘¼‘‚Ì•¶‰»‚âŠwZ‚Ö‚ÌŠÖS‚ðŽ‚‚«‚Á‚©‚¯‚Æ‚È‚Á‚½‚±‚Æ‚Å‚ ‚éB‘æŽO‚ÍC‹CŒó•Ï“®–â‘è‚ɑ΂µ‚ăOƒ[ƒoƒ‹‚ÈŽ‹“_‚Ål‚¦‚é‚«‚Á‚©‚¯‚ð—^‚¦‚ç‚ꂽ‚Æ‚¢‚¤‚±‚Æ‚Å‚ ‚éB en-copyright= kn-copyright= en-aut-name=BEKKIMoeka en-aut-sei=BEKKI en-aut-mei=Moeka kn-aut-name=•Ê–Ø–G‰Ê kn-aut-sei=•Ê–Ø kn-aut-mei=–G‰Ê aut-affil-num=1 ORCID= en-aut-name=ZHOUXingxing en-aut-sei=ZHOU en-aut-mei=Xingxing kn-aut-name=Žü¯¯ kn-aut-sei=Žü kn-aut-mei=¯¯ aut-affil-num=2 ORCID= en-aut-name=KUWABARAToshinori en-aut-sei=KUWABARA en-aut-mei=Toshinori kn-aut-name=ŒKŒ´•q“T kn-aut-sei=ŒKŒ´ kn-aut-mei=•q“T aut-affil-num=3 ORCID= affil-num=1 en-affil=Tokyo Metropolitan Ogawa High School kn-affil=“Œ‹ž“s—§¬ì‚“™ŠwZ affil-num=2 en-affil=School of Foreign Languages, Shijiazhuang University kn-affil=ΉƑ‘Šw‰@ŠO‘ŒêŠw‰@i’†‘j affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=‘Û—‰ð‹³ˆç (international understanding education) kn-keyword=‘Û—‰ð‹³ˆç (international understanding education) en-keyword=Œö–¯‰È (civics) kn-keyword=Œö–¯‰È (civics) en-keyword=’PŒ³ŠJ”­ (unit development) kn-keyword=’PŒ³ŠJ”­ (unit development) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=297 end-page=311 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Exploring Home Learning That Bridges Lessons to Foster Autonomous and Self-Directed Learning kn-title=Žå‘Ì“IEŽ©—¥“I‚ÈŠw‚Ñ‚ð–G‰è‚³‚¹‚éuŽö‹Æ‚ÆŽö‹Æ‚ð‚‚Ȃ®‰Æ’ëŠwKv‚Ì’T‹† en-subtitle= kn-subtitle= en-abstract=@For students to develop the ability to learn independently, they need learning experiences that extend beyond the classroom, including at home. In other words, learning is not confined to the classroom but is reinforced through a wide range of activities. This study aimed to nurture gautonomous and self-directed learningh among students in the second grade at a public junior high school by integrating classroom and home learning. Teachers emphasized the importance of learning strategies and goal setting, and encouraged metacognition. As a result, students became more aware of the self-regulated learning cycle and began exploring learning strategies tailored to their needs. In addition, working at home on assignments connected to the class not only increased studentsf active participation in class but also improved their motivation to learn independ ently outside of class. kn-abstract=@¶“k‚ªŽ©‚çŠwK‚ði‚ß‚Ä‚¢‚­—Í‚ðg‚É•t‚¯‚é‚É‚ÍCŽö‹Æ“à‚¾‚¯‚Å‚È‚­C‰Æ’ë‚È‚ÇŽö‹ÆŠO‚Ìê‚Å‚ÌŠwKŒoŒ±‚ðÏ‚Þ•K—v‚ª‚ ‚éB‚‚܂èCŠwK‚ÍŽö‹Æ“à‚¾‚¯‚ÅŠ®Œ‹‚·‚é‚Ì‚Å‚Í‚È‚­CL”Í‚ÈŠˆ“®‚ð’Ê‚µ‚Ĭ—§‚·‚éB–{Œ¤‹†‚Å‚ÍCŒö—§’†ŠwZ‚Ì‘æ2Šw”N‚ð‘ÎÛ‚ÉŽö‹Æ‚ƉƒëŠwK‚ð˜AŒg‚³‚¹‚éŽÀ‘H‚ðs‚¢C¶“k‚ÌuŽå‘Ì“IEŽ©—¥“I‚ÈŠw‚Ñv‚ð–G‰è‚³‚¹‚邱‚Æ‚ð–ÚŽw‚µ‚½B‹³Žt‚ªŠwK•û—ª‚â–Ú•WÝ’è‚Ìd—v«‚ð“`‚¦Cƒƒ^”F’m‚𑣂·‚±‚Æ‚ÅC¶“k‚ÍŽ©ŒÈ’²®ŠwK‚̃TƒCƒNƒ‹‚ðˆÓŽ¯‚µCŽ©•ª‚È‚è‚ÌŠwK•û—ª‚ð’T‹‚·‚é‚悤‚É‚È‚Á‚½B‚Ü‚½C‰Æ’ëŠwK‚ÅŽö‹Æ‚ɂ‚Ȃª‚é‰Û‘è‚ÉŽæ‚è‘g‚Þ‚±‚Æ‚ÅCŽö‹Æ‚Ö‚ÌŽå‘Ì“I‚ÈŽQ‰Á‚ÆCŽö‹ÆŠO‚ÅŽ©—¥“I‚ÉŠw‚ÔˆÓ—~‚ª‘£‚³‚ê‚邱‚Æ‚àŽ¦´‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=TANAKAJunko en-aut-sei=TANAKA en-aut-mei=Junko kn-aut-name=“c’†ƒŽq kn-aut-sei=“c’† kn-aut-mei=ƒŽq aut-affil-num=1 ORCID= en-aut-name=MISAWARyo en-aut-sei=MISAWA en-aut-mei=Ryo kn-aut-name=ŽO‘ò—Ç kn-aut-sei=ŽO‘ò kn-aut-mei=—Ç aut-affil-num=2 ORCID= affil-num=1 en-affil=Okayama Municipal Hosen Junior High School kn-affil=‰ªŽRŽs—§–Fò’†ŠwZ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=Žö‹Æ‚ƉƒëŠwK‚̘AŒg (coordination between classroom and home learning) kn-keyword=Žö‹Æ‚ƉƒëŠwK‚̘AŒg (coordination between classroom and home learning) en-keyword=Ž©ŒÈ’²®ŠwK (self-regulated learning) kn-keyword=Ž©ŒÈ’²®ŠwK (self-regulated learning) en-keyword=h‘è (homework) kn-keyword=h‘è (homework) en-keyword=Žö‹Æ‰ü‘P (lesson improvement) kn-keyword=Žö‹Æ‰ü‘P (lesson improvement) END start-ver=1.4 cd-journal=joma no-vol=18 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clipping closure length is a crucial factor for delayed bleeding after endoscopic papillectomy: a retrospective multicenter cohort study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Bleeding is a serious and frequent adverse event that occurs during and after endoscopic papillectomy (EP). Previous studies have highlighted the effectiveness of preventive clipping closure of the resection site in preventing post-EP bleeding. However, the optimal length of closure remained unclear.
Objectives: We aimed to clarify the optimal clipping length at the post-EP resection site to prevent delayed bleeding.
Design: This study was a multicenter retrospective cohort study.
] Methods: We retrospectively analyzed patients who were consecutively admitted to nine high-volume centers for EP between November 2003 and October 2023. The primary outcome was the frequency of delayed bleeding based on the closure length. The optimal closure length rate of the resected site to prevent delayed bleeding was determined using a receiver operating characteristic curve. Secondary outcomes were the incidence, treatment outcomes, and risk factors for post-EP delayed bleeding.
Results: A total of 130 patients who underwent EP were analyzed. Delayed bleeding was observed in 22 (17%) patients, occurring more frequently in cases without clipping closure than in those with clipping closure (28% (13/47) vs 11% (9/83); p = 0.014). Among 83 patients who underwent clipping closure, delayed bleeding occurred more frequently with a closure length rate <65% than in those with a closure rate >= 65% (25% (5/20) vs 6% (4/63); p = 0.019). Multivariate analysis showed that a closure rate <65% was the risk factor for delayed bleeding (odds ratio, 6.3; 95% confidence interval, 1.2-33; p = 0.030) in cases with clipping.
Conclusion: Clipping closure was effective in preventing delayed bleeding, and closure length rate >= 65% of the resected site significantly reduced post-EP delayed bleeding. en-copyright= kn-copyright= en-aut-name=FujiiYuki en-aut-sei=Fujii en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsumotoKazuyuki en-aut-sei=Matsumoto en-aut-mei=Kazuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OchiKiyoaki en-aut-sei=Ochi en-aut-mei=Kiyoaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HimeiHitomi en-aut-sei=Himei en-aut-mei=Hitomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SakakiharaIchiro en-aut-sei=Sakakihara en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UetaEijiro en-aut-sei=Ueta en-aut-mei=Eijiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ToyokawaTatsuya en-aut-sei=Toyokawa en-aut-mei=Tatsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HaradaRyo en-aut-sei=Harada en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OgawaTaiji en-aut-sei=Ogawa en-aut-mei=Taiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TomodaTakeshi en-aut-sei=Tomoda en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KatoHironari en-aut-sei=Kato en-aut-mei=Hironari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=SatoRyosuke en-aut-sei=Sato en-aut-mei=Ryosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=ObataTaisuke en-aut-sei=Obata en-aut-mei=Taisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=MatsumiAkihiro en-aut-sei=Matsumi en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=MiyamotoKazuya en-aut-sei=Miyamoto en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=UchidaDaisuke en-aut-sei=Uchida en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=HoriguchiShigeru en-aut-sei=Horiguchi en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=TsutsumiKoichiro en-aut-sei=Tsutsumi en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=OtsukaMotoyuki en-aut-sei=Otsuka en-aut-mei=Motoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Gastroenterology, Fukuyama City Hospital kn-affil= affil-num=4 en-affil=Department of Gastroenterology, Hiroshima City Hiroshima Citizens Hospital kn-affil= affil-num=5 en-affil=Department of Gastroenterology, Kagawa Prefectural Central Hospital kn-affil= affil-num=6 en-affil=Department of Gastroenterology, National Hospital Organization, Iwakuni Clinical Center kn-affil= affil-num=7 en-affil=Department of Gastroenterology, National Hospital Organization, Fukuyama Medical Center kn-affil= affil-num=8 en-affil=Department of Gastroenterology, Japanese Red Cross Okayama Hospital kn-affil= affil-num=9 en-affil=Department of Gastroenterology, Tsuyama Chuo Hospital kn-affil= affil-num=10 en-affil=Department of Gastroenterology, Okayama City Hospital kn-affil= affil-num=11 en-affil=Department of Gastroenterology, Okayama City Hospital kn-affil= affil-num=12 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=13 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=14 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=15 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=16 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=17 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=18 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= affil-num=19 en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital kn-affil= en-keyword=clipping closure kn-keyword=clipping closure en-keyword=delayed bleeding kn-keyword=delayed bleeding en-keyword=endoscopic papillectomy kn-keyword=endoscopic papillectomy END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=281 end-page=295 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Development Support a Child with Autism to Acquisition of Intersubjective Communication: Through the Environmental Setting of Play with Shared Positive Emotions kn-title=ASD Ž™‚É‚¨‚¯‚é‘ŠŒÝ“`’Bsˆ×‚ÌŠl“¾‚ð–ÚŽw‚µ‚½—V‚Ñ‚ð’†S‚Æ‚µ‚½ƒRƒ~ƒ…ƒjƒP[ƒVƒ‡ƒ“Žw“±@ƒ|ƒWƒeƒBƒu‚Èî“®‚Ì‹¤—L‚ð¶‚Ýo‚·—V‚т̊‹«Ý’è‚ð’Ê‚µ‚Ä en-subtitle= kn-subtitle= en-abstract=In this study, a play-based instruction was used to promote the acquisition of intersubjective communication in a special needs school for students with intellectual disabilities. The participant was a first-grade boy with autism. As a result, the boy began to show intersubjective communication and to respond to the teacher's instruction. It was suggested that four aspects of the play environment may have promoted the acquisition of intersubjective communication: 1) attractive toys, 2) play with the teacher through attractive toys, 3) intervention according to the developmental process of the target children's play, and 4) empathic involvement to encourage the affective sharing. kn-abstract=@Ž©•ÂƒXƒyƒNƒgƒ‰ƒ€ÇŽ™‚ÍC‘ŠŒÝ“`’Bsˆ×‚ÌŠl“¾‚É’x‚ꂪ‚ ‚邱‚Æ‚ªŽw“E‚³‚ê‚Ä‚¢‚éB–{Œ¤‹†‚Å‚ÍCŽ©•ÂƒXƒyƒNƒgƒ‰ƒ€Ç‚Ìf’f‚Ì‚ ‚é’m“IáŠQ“Á•ÊŽx‰‡ŠwZ¬Šw•”‚P”N¶’jŽ™‚ð‘ÎÛ‚ÉC‘ŠŒÝ“`’Bsˆ×‚ÌŠl“¾‚ð–ÚŽw‚µ‚ÄC—V‚Ñ‚ð’†S‚Æ‚µ‚½Žw“±‚ðs‚Á‚½B‚»‚ÌŒ‹‰ÊC‘ÎÛŽ™‚Ì—V‚Ñ‚ªuŠ´Šo‰^“®“I—V‚Ñvu‹@”\“I—V‚Ñv‚©‚çuÛ’¥“I—V‚ÑvuŽÐ‰ï“I—V‚Ñv‚ւƈÚs‚·‚é‚É”º‚¢C‘ŠŒÝ“`’Bsˆ×‚ªŒ©‚ç‚ê‚é‚悤‚É‚È‚Á‚½B‚Ü‚½C‹³Žt‚É‚æ‚é“­‚«Š|‚¯‚ւ̉ž“š‚àŒ©‚ç‚ê‚é‚悤‚É‚È‚èCƒ|ƒWƒeƒBƒu‚Èî“®‚Ì‹¤—L‚ª¶‚Ýo‚³‚ê‚â‚·‚¢—V‚т̊‹«Ý’肪C‘ŠŒÝ“`’Bsˆ×‚ÌŠl“¾‚É‚¨‚¢‚ÄŒø‰Ê“I‚Å‚ ‚Á‚½‚±‚Æ‚ªŽ¦´‚³‚ꂽB—V‚ъ‹«‚ɂ‚¢‚Ä‚ÍC1j–£—Í“I‚ÈŠß‹ïC2j–£—Í“I‚ÈŠß‹ï‚ð‰î‚µ‚½‹³Žt‚Æ‚Ì—V‚ÑC3j‘ÎÛŽ™‚Ì—V‚Ñ‚Ì”­’B’iŠK‚ɉž‚¶‚½‰î“üC4jî“®‚Ì‹¤—L‚𑣂·‹¤Š´“IŠÖ‚í‚è‚Ì‚S“_‚ª‘ŠŒÝ“`’Bsˆ×‚ÌŠl“¾‚𑣂µ‚½‰Â”\«‚ªl‚¦‚ç‚ꂽB en-copyright= kn-copyright= en-aut-name=KAKUHARAKeisuke en-aut-sei=KAKUHARA en-aut-mei=Keisuke kn-aut-name=ŠpŒ´‰À‰î kn-aut-sei=ŠpŒ´ kn-aut-mei=‰À‰î aut-affil-num=1 ORCID= en-aut-name=BANMarina en-aut-sei=BAN en-aut-mei=Marina kn-aut-name=”º^—¢“Þ kn-aut-sei=”º kn-aut-mei=^—¢“Þ aut-affil-num=2 ORCID= en-aut-name=TANJITakayuki en-aut-sei=TANJI en-aut-mei=Takayuki kn-aut-name=’OŽ¡Œh”V kn-aut-sei=’OŽ¡ kn-aut-mei=Œh”V aut-affil-num=3 ORCID= affil-num=1 en-affil=Tobi Special School kn-affil=‰ªŽRŒ§—§“Œ”õŽx‰‡ŠwZ affil-num=2 en-affil=Special School Affiliated with the Faculty of Education at Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆçŠw•”•‘®“Á•ÊŽx‰‡ŠwZ affil-num=3 en-affil=Institute of Human Sciences, University of Tsukuba kn-affil=’}”g‘åŠwlŠÔŒn en-keyword=Ž©•ÂƒXƒyƒNƒgƒ‰ƒ€Ç (a Child with Autism) kn-keyword=Ž©•ÂƒXƒyƒNƒgƒ‰ƒ€Ç (a Child with Autism) en-keyword=‘ŠŒÝ“`’Bsˆ× (Intersubjective Communication) kn-keyword=‘ŠŒÝ“`’Bsˆ× (Intersubjective Communication) en-keyword=î“®‚Ì‹¤—L (effective sharing) kn-keyword=î“®‚Ì‹¤—L (effective sharing) en-keyword=—V‚т̊‹«Ý’è (Setting of Play) kn-keyword=—V‚т̊‹«Ý’è (Setting of Play) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=267 end-page=279 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Examination of Practical Cases of Career Education to Promote Self-Understanding in Elementary School Students: Utilizing Character Strengths Intervention kn-title=Ž™“¶‚ÌŽ©ŒÈ—‰ð‚𑣂·ƒLƒƒƒŠƒA‹³ˆç‚ÌŽÀ‘HŽ–—á‚ÌŒŸ“¢@\‹­‚݉î“ü‚ðŠˆ—p‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract=This study explored the implementation of Character Strengths Intervention (CSI), rooted in positive psychology, to enhance self-awareness in career education for elementary school students. The intervention targeted 4th-grade students at a public elementary school, aiming to facilitate their recognition and utilization of character strengths in relation to future aspirations. Through structured lessons, students deepened their understanding of personal strengths and developed increased awareness of how to apply these attributes towards their future goals. Moreover, peer-focused activities designed to acknowledge individual strengths contributed to improved interpersonal relationships among students. However, challenges persist, including the need for comprehensive systematic and developmental planning of career education across the entire school, as well as providing tailored support for students who find it difficult to identify and leverage their unique strengths. kn-abstract=–{Œ¤‹†‚Å‚ÍCŒö—§¬ŠwZ4”N¶‚ð‘ÎÛ‚ÉCƒLƒƒƒŠƒA‹³ˆç‚É‚¨‚¯‚鎩ŒÈ—‰ð”\—͂̈笂ð–Ú“I‚Æ‚µCƒ|ƒWƒeƒBƒuS—Šw‚ÉŠî‚­«Ši“Á«“I‹­‚݉î“ü (Character Strengths InterventionFCSI) ‚Æ«—ˆ‚Ì–²‚ɂ‚¢‚Ä‚ÌŠwK‚ðŠÖ˜A•t‚¯‚½Šw‹‰Šˆ“® (‚R) ‚ÌŽö‹Æ‚ðs‚Á‚½B–{ŽÀ‘H‚ð’Ê‚µ‚ÄCŽ™“¶‚ÍŽ©•ª‚Ì‹­‚Ý‚ð—‰ð‚µC‚»‚ê‚ð«—ˆ‚ÉŠˆ‚©‚»‚¤‚Æ‚·‚éˆÓŽ¯‚ª‚‚Ü‚é‚Æ‚Æ‚à‚ÉCŒÝ‚¢‚Ì‹­‚Ý‚ð”F‚߇‚¤Šˆ“®‚É‚æ‚Á‚ÄŽ™“¶“¯Žm‚ÌŠÖŒW«‚Ì\’z‚ª‘£i‚³‚ꂽBˆê•û‚ÅCŠwZ‘S‘̂ł̃LƒƒƒŠƒA‹³ˆç‚ÌŒn“«‚Æ”­“W«‚ÌŒŸ“¢C‹­‚Ý‚ÌŠˆ—p‚ª“‚¢Ž™“¶‚ւ̌•ʎx‰‡‚Ì•K—v«‚ª¡Œã‚̉ۑè‚Æ‚µ‚ÄŽw“E‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=YOSHIKAWAShinji en-aut-sei=YOSHIKAWA en-aut-mei=Shinji kn-aut-name=‹gìL“ñ kn-aut-sei=‹gì kn-aut-mei=L“ñ aut-affil-num=1 ORCID= en-aut-name=ISODAKouhei en-aut-sei=ISODA en-aut-mei=Kouhei kn-aut-name=ˆé“c_•½ kn-aut-sei=ˆé“c kn-aut-mei=_•½ aut-affil-num=2 ORCID= en-aut-name=IZUMITsuguyuki en-aut-sei=IZUMI en-aut-mei=Tsuguyuki kn-aut-name=ˆÉZŒps kn-aut-sei=ˆÉZ kn-aut-mei=Œps aut-affil-num=3 ORCID= affil-num=1 en-affil=Uwanari Elementary School kn-affil=‘q•~Žs—§ã¬¬ŠwZ affil-num=2 en-affil=Uwanari Elementary School kn-affil=‘q•~Žs—§ã¬¬ŠwZ affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=ƒLƒƒƒŠƒA‹³ˆç (Career Education) kn-keyword=ƒLƒƒƒŠƒA‹³ˆç (Career Education) en-keyword=Ž©ŒÈ—‰ð (Self-awareness) kn-keyword=Ž©ŒÈ—‰ð (Self-awareness) en-keyword=«Ši“Á«“I‹­‚Ý (Character Strengths) kn-keyword=«Ši“Á«“I‹­‚Ý (Character Strengths) en-keyword=Šw‹‰Šˆ“® (‚R) (Classroom Activities (3)) kn-keyword=Šw‹‰Šˆ“® (‚R) (Classroom Activities (3)) en-keyword=Ž™“¶ (Children) kn-keyword=Ž™“¶ (Children) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=251 end-page=265 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Bridging the Gap: Outcomes and Challenges of a Collaborative Start Curriculum for Seamless Transition to Elementary School kn-title=¬ŠwZ‚Ö‚ÌŠŠ‚ç‚©‚ȈÚs‚ðŽx‚¦‚éƒXƒ^[ƒgƒJƒŠƒLƒ…ƒ‰ƒ€‹¤“¯•Ò¬ƒvƒƒWƒFƒNƒg‚̬‰Ê‚Ɖۑè en-subtitle= kn-subtitle= en-abstract=In this practice, a joint curriculum development project was launched to ease the transition for children in the gbridge periodh from age five to first grade, involving five discussions between kindergarten and elementary school teachers. Participants reflected on these discussions, and the content was analyzed. (1) A screening sheet to identify children who gcause concernh helped clarify differences in observations, leading to a shared understanding of child perceptions. (2) Teachers recognized differences in their views of children and education, improving their attitudes toward compromise and increasing awareness of the need to smooth the transition. However, an overloaded elementary school curriculum was noted, limiting the flexible application of the start curriculum and hindering child-centered education. kn-abstract=–{ŽÀ‘H‚Å‚ÍC‚TÎŽ™‚©‚笊w‚P”N¶‚Ìu‰Ë‚¯‹´Šúv‚ÌŠŠ‚ç‚©‚ȈÚs‚ÉÅ“_‚ð“–‚Ä‚½ƒXƒ^[ƒgƒJƒŠƒLƒ…ƒ‰ƒ€‹¤“¯•Ò¬ƒvƒƒWƒFƒNƒg‚𗧂¿ã‚°C—c’t‰€‚ƬŠwZ‚Ì‹³ˆõ‚ªW‚Ü‚Á‚Ä‚T‰ñ‚̘b‡‚¢‚ðs‚Á‚½B–{ƒvƒƒWƒFƒNƒg‚ð•]‰¿‚·‚邽‚ß‚ÉCŽQ‰ÁŽÒ‚ɘb‡‚¢‚ÌU•Ô‚è‚ð‘‚¢‚Ä‚à‚ç‚¢C‚»‚Ì“à—e‚ðŒŸ“¢‚µ‚½B¬‰Ê‚Æ‚µ‚ÄC‡@ƒXƒNƒŠ[ƒjƒ“ƒOƒV[ƒg‚ðŽg‚Á‚ÄCu‹C‚É‚È‚évŽq‹Ÿ‚ð’Šo‚µCŒ©Žæ‚è‚̈Ⴂ‚ð‰ÂŽ‹‰»‚·‚邱‚Æ‚ÅC‘ŠŒÝ‚ÌŽq‹ŸŠÏ‚ɂ‚¢‚Ä‹¤’Ê—‰ð‚ð}‚邱‚Æ‚ª‚Å‚«‚½B‡A—c’t‰€‚ƬŠwZC‘o•û‚Ì‹³ˆõ‚ªŒÝ‚¢‚ÌŽq‹ŸŠÏE‹³ˆçŠÏ‚̈Ⴂ‚ð—‰ð‚µC•à‚ÝŠñ‚낤‚Æ‚·‚éŽp¨‚âZŽíŠÔ‚ÌÚ‘±‚ð‚æ‚芊‚ç‚©‚É‚µ‚悤‚Æ‚·‚éˆÓŽ¯‚ÌŒüオŠm”F‚³‚ꂽBˆê•ûC‰Û‘è‚Æ‚µ‚ÄCƒXƒ^[ƒgƒJƒŠƒLƒ…ƒ‰ƒ€‚Ì_“î‚ȉ^—p‚⬊wZ‹³ˆç‚É‚¨‚¯‚éŽq‹ŸŽå‘Ì‚Ì‹³ˆç‚ÌŽÀŒ»‚ð–W‚°‚鋳ˆç‰Û’ö‚̉ßÏÚó‘Ô‚Ì–â‘肪Žw“E‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=OKURAHisashi en-aut-sei=OKURA en-aut-mei=Hisashi kn-aut-name=‘å‘q®Žu kn-aut-sei=‘å‘q kn-aut-mei=®Žu aut-affil-num=1 ORCID= en-aut-name=MATSUINoriko en-aut-sei=MATSUI en-aut-mei=Noriko kn-aut-name=¼ˆä‹IŽq kn-aut-sei=¼ˆä kn-aut-mei=‹IŽq aut-affil-num=2 ORCID= en-aut-name=IZUMITsuguyuki en-aut-sei=IZUMI en-aut-mei=Tsuguyuki kn-aut-name=ˆÉZŒps kn-aut-sei=ˆÉZ kn-aut-mei=Œps aut-affil-num=3 ORCID= affil-num=1 en-affil=Hayashima Kindergarten kn-affil=‘“‡’¬—§‘“‡—c’t‰€ affil-num=2 en-affil=Hayashima Kindergarten kn-affil=‘“‡’¬—§‘“‡—c’t‰€ affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=‰Ë‚¯‹´ƒvƒƒOƒ‰ƒ€ (Bridge Program) kn-keyword=‰Ë‚¯‹´ƒvƒƒOƒ‰ƒ€ (Bridge Program) en-keyword=ƒXƒ^[ƒgƒJƒŠƒLƒ…ƒ‰ƒ€ (Start Curriculum) kn-keyword=ƒXƒ^[ƒgƒJƒŠƒLƒ…ƒ‰ƒ€ (Start Curriculum) en-keyword=ƒXƒNƒŠ[ƒjƒ“ƒOƒV[ƒg (Screening Sheet) kn-keyword=ƒXƒNƒŠ[ƒjƒ“ƒOƒV[ƒg (Screening Sheet) en-keyword=ƒJƒŠƒLƒ…ƒ‰ƒ€EƒI[ƒo[ƒ[ƒh (Curriculum Overload) kn-keyword=ƒJƒŠƒLƒ…ƒ‰ƒ€EƒI[ƒo[ƒ[ƒh (Curriculum Overload) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=235 end-page=249 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Practical Research on Nurturing the Next Generation of Classical Japanese Instrument Music That Connects the Local and the Global Community (1): Analysis of External Evaluations of the gOkayama International Classical Japanese Instruments Student Festivalh kn-title=’nˆæŽÐ‰ï‚ƃOƒ[ƒoƒ‹‚ð‚‚Ȃ®˜aŠyŠí‰¹ŠyŽŸ¢‘ãˆç¬‚ÌŽÀ‘HŒ¤‹†i‚Pj@u‚¨‚©‚â‚Ü‘Û˜aŠyŠíŠw¶ƒtƒFƒXƒeƒBƒoƒ‹vŠO“I•]‰¿‚Ì•ªÍ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–{e‚Å‚ÍCu˜aŠyŠí‰¹Šy‹y‚Ñ‹³ˆç‚Ì‹’“_‚­‚è‚ÌŽÀ‘HŒ¤‹†v‚̈êŠÂ‚Æ‚µ‚ÄŠJµ‚½u‚¨‚©‚â‚Ü‘Û˜aŠyŠíŠw¶ƒtƒFƒXƒeƒBƒoƒ‹v‚ÌŽæ‚è‘g‚݂ɂ‚¢‚ÄC‚»‚ÌŠT—v‚ð•ñ‚·‚é‚Æ‚Æ‚à‚ÉCŠO“I•]‰¿‚Æ‚µ‚Äu‚¨‚©‚â‚Ü‘Û˜aŠyŠíŠw¶ƒtƒFƒXƒeƒBƒoƒ‹ƒRƒ“ƒT[ƒgvI‰‰Œã‚ÉŽÀŽ{‚µ‚½ˆê”Ê—ˆêŽÒ‘ÎÛ‚ÌŽ¿–⎆’²¸‹y‚уtƒFƒXƒeƒBƒoƒ‹‚ðŽQŠÏ‚µ‚½‰ªŽRŒ§“à‚ÌŠwZŠÖŒWŽÒ‘ÎÛ‚ÌŽ¿–⎆’²¸‚ðŽæ‚èã‚°CˆÓ‹`‚Ɖۑè‚ɂ‚¢‚ÄŒŸ“¢‚µ‚½B
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kn-title=’†ŠwZ‰Æ’ë‰È‚É‚¨‚¯‚é‚—îŠúŠwK‚ÌŽÀ‘H@\ƒ‰ƒCƒtƒR[ƒX‚Ì’†‚Å‚—îŠú‚ðl‚¦‚é\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–{Œ¤‹†‚Å‚ÍC’†ŠwZ‰Æ’ë‰È‚É‚¨‚¯‚é‚—îŠúŠwK‚ÌŽö‹ÆŽÀ‘H‚ð’Ê‚µ‚ÄC’†Šw¶‚ª‚—îŠú‚ðŽ©‚ç‚̃‰ƒCƒtƒR[ƒX‚Ì’†‚Ål‚¦‚邱‚Æ‚ª‚Å‚«‚é‚©‚𖾂炩‚É‚·‚邱‚Æ‚ð–Ú“I‚Æ‚µC’†Šw¶‚ð‘ÎÛ‚É‚—îŽÒC‚—îŠúŠwK‚ðŽÀ‘H‚µ‚½B’†ŠwZ‰Æ’ë‰È‚É‚¨‚¯‚é‚—îŽÒ‚â‚—îŠú‚ÉŠÖ˜A‚·‚éŠwK“à—e‚ðŠm”F‚·‚邽‚ßCw’†ŠwZŠwKŽw“±—v—Ìi•½¬29”NŽ¦j‰ðà‹ZpE‰Æ’ë•Òx‚Ɖƒë‰È‚Ì‹³‰È‘‚ð•ªÍ‚µ‚½B’†Šw¶‚ª‚—îŽÒC‚—îŠú‚ÉŠÖ‚µ‚ÄŽ©•ª‚̃‰ƒCƒtƒR[ƒX‚̈ꕔ‚Æ‚µ‚Äl‚¦‚邱‚Æ‚ª‚Å‚«‚é‚悤‚ÉŠwKŽw“±ˆÄ‚ð쬂µC‰ªŽRŒ§“à‚ÌT’†ŠwZ3”N¶‚ð‘ÎÛ‚ÉŽö‹Æ‚ðs‚Á‚½BŽö‹ÆŽÀ‘H‚ÌŒ‹‰ÊCŠwK‚Ì[‚Ü‚è‚ðŠ´‚¶‚½‚Ɖñ“š‚µ‚½’†Šw¶‚ª‘½‚­C‚—îŠú‚ð«—ˆ‚ÌŽ©‚ç‚̃‰ƒCƒtƒR[ƒX‚Ì’†‚Ål‚¦‚ç‚ê‚é‚悤‚É‚È‚Á‚½’†Šw¶‚à­‚È‚­‚È‚¢‚±‚Æ‚ðŠm”F‚Å‚«‚½B‚µ‚©‚µC‚—îŽÒ‚ÉŠÖ‚·‚éŠwK‚ð‚æ‚è–]‚Þ’†Šw¶‚ª”¼”‚ð‰º‰ñ‚èC’†Šw¶‚ªX‚È‚éŠwK‚̈ӗ~‚â‹»–¡‚ðŽ‚Ä‚é‚悤‚ÈŠwK•û–@‚ÌH•v‚ª•K—v‚Å‚ ‚邱‚Æ‚à–¾‚ç‚©‚É‚È‚Á‚½B en-copyright= kn-copyright= en-aut-name=TAKATAMihoko en-aut-sei=TAKATA en-aut-mei=Mihoko kn-aut-name=‚“c…•äŽq kn-aut-sei=‚“c kn-aut-mei=…•äŽq aut-affil-num=1 ORCID= en-aut-name=LEEKyoungwon en-aut-sei=LEE en-aut-mei=Kyoungwon kn-aut-name=—›ûm•Q kn-aut-sei=—› kn-aut-mei=ûm•Q aut-affil-num=2 ORCID= affil-num=1 en-affil=Student At Graduate School of Education, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@¶ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=‚—îŽÒ kn-keyword=‚—îŽÒ en-keyword=‚—îŠú kn-keyword=‚—îŠú en-keyword=’†ŠwZ‰Æ’ë‰È kn-keyword=’†ŠwZ‰Æ’ë‰È en-keyword=ŠwKŽw“±—v—Ì kn-keyword=ŠwKŽw“±—v—Ì en-keyword=‹³‰È‘ kn-keyword=‹³‰È‘ en-keyword=Elderly (Aging) kn-keyword=Elderly (Aging) en-keyword=junior High School Technology-Home Economics (Home Economics) kn-keyword=junior High School Technology-Home Economics (Home Economics) en-keyword=Courses of Study Textbooks kn-keyword=Courses of Study Textbooks END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=207 end-page=218 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Lesson Structure of Elementary Social Studies Law-Related Education Focusing on the Concept of Contract: Through the Designing of a Unit on Production and Sales in the Third Grade kn-title=Œ_–ñŠT”O‚É’–Ú‚µ‚½¬ŠwZŽÐ‰ï‰È–@‹³ˆç‚ÌŽö‹Æ\¬@\‘æ‚RŠw”N‚̶ŽY‚â”Ì”„‚ÉŠÖ‚·‚é’PŒ³‚ÌŠJ”­‚ð’Ê‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract=This paper clarifies the Lesson Theory of Law-Related Education as citizenship education in elementary social studies, clarifies the Theory of lesson structure, and develops a unit on sales work in the middle grades. Research has been conducted in elementary Law-Related Education based on the theory of developmental psychology, but systematization as elementary social studies has not been promoted. In the elementary school social studies, the content of the third grade "about the work of production and sales found in the community" is set. Sales equally involve legal issues such as sales contracts. this paper suggests an elementary social studies unit using a supermarket as a teaching material, based on Law-Related Education research accumulated in social studies education research to date. kn-abstract=@–{˜_•¶‚ÍA¬ŠwZŽÐ‰ï‰È‚É‚¨‚¯‚éŽs–¯«‹³ˆç‚Æ‚µ‚Ä‚Ì–@‹³ˆç‚Ì‚ ‚è•û‚ðŒŸ“¢‚µA‚»‚ÌŽö‹Æ\¬Œ´—‚𖾂炩‚É‚µ‚½‚¤‚¦‚ÅA’†Šw”N‚Ì‹³ˆç“à—e‚Å‚ ‚é”Ì”„‚ÌŽdŽ–‚ÉŠÖ‚·‚é’PŒ³ŠJ”­‚ðs‚¤‚à‚Ì‚Å‚ ‚éB‚±‚ê‚܂ŬŠwZ–@‹³ˆç‚Å‚ÍA”­’BS—Šw‚̘_‚ðŠî‚É‚µ‚È‚ª‚猤‹†‚ªi‚ß‚ç‚ê‚Ä‚«‚½‚ªA¬ŠwZŽÐ‰ï‰È–@‹³ˆç‚Æ‚µ‚Ä‚Ì‘ÌŒn“I‚ÈŒ¤‹†‚Í\•ª‚Å‚Í‚È‚©‚Á‚½B¬ŠwZ‘æ‚RŠw”N‚̎Љï‰È‚Å‚ÍA‘æ‚RŠw”Nu’nˆæ‚É‚Ý‚ç‚ê‚鶎Y‚â”Ì”„‚ÌŽdŽ–‚ɂ‚¢‚Äv‚Ì“à—e‚ªÝ’肳‚ê‚Ä‚¢‚éB²“¡‚̓X[ƒp[ƒ}[ƒPƒbƒg‚ð‹³Þ‚Æ‚µ‚ĬŠwZŽÐ‰ï‰È‚ÅŒoÏŠT”O‚ðŒ`¬‚·‚éŽö‹Æ‚ðŠJ”­‚µA‚»‚Ì—LŒø«‚ðŒŸØ‚µ‚½Bˆê•û‚ÅA”Ì”„‚É‚Í”„”ƒŒ_–ñ‚̂悤‚È–@“I–â‘è‚à”­¶‚·‚éB–{˜_•¶‚Å‚ÍA‚±‚ê‚܂ł̎Љï‰È‹³ˆçŒ¤‹†‚É‚¨‚¢‚Ä’~Ï‚³‚ê‚Ä‚«‚½–@‹³ˆç˜_‚≿’lŠÏŒ`¬˜_‚̬‰Ê‚𓥂܂¦AƒX[ƒp[ƒ}[ƒPƒbƒg‚ð‹³Þ‚Æ‚µ‚½¬ŠwZŽÐ‰ï‰È’PŒ³ŠJ”­‚ðs‚¤B en-copyright= kn-copyright= en-aut-name=MIYAMOTOAyuha en-aut-sei=MIYAMOTO en-aut-mei=Ayuha kn-aut-name=‹{–{‚ ‚ä‚Í kn-aut-sei=‹{–{ kn-aut-mei=‚ ‚ä‚Í aut-affil-num=1 ORCID= en-aut-name=KUWABARAToshinori en-aut-sei=KUWABARA en-aut-mei=Toshinori kn-aut-name=ŒKŒ´•q“T kn-aut-sei=ŒKŒ´ kn-aut-mei=•q“T aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Humanities and Social Sciences, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È”ŽŽmŒãŠú‰Û’ö affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=–@‹³ˆç (Law-Related Education) kn-keyword=–@‹³ˆç (Law-Related Education) en-keyword=‰“™‹³ˆç (Elementary School Education) kn-keyword=‰“™‹³ˆç (Elementary School Education) en-keyword=¬ŠwZŽÐ‰ï‰È (Social Studies) kn-keyword=¬ŠwZŽÐ‰ï‰È (Social Studies) en-keyword=–¯–@ŠwK (Civil Law Education) kn-keyword=–¯–@ŠwK (Civil Law Education) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=191 end-page=205 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Prevention of Apathy in High School Students Perspective on Time Management and Future Prospects kn-title=ƒAƒpƒV[ŒXŒü‚©‚ç‚Ý‚½‚Z¶‚Ì–³‹C—Í‚Ì—\–h‚ɂ‚¢‚Ä@\ƒ^ƒCƒ€ƒ}ƒlƒWƒƒ“ƒgC«—ˆ“W–]‚Æ‚ÌŠÖŒW‚ð’Ê‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract=@According to the Ministry of Education in Japan (2023), apathy is the leading cause of truancy among high school students, with the percentage of nonattendance at 40%. Therefore, this study aimed to examine the prevention of apathy among high school students. Apathy among college students has been examined as a propensity for apathy. This study presupposes that apathy among high school students is also associated with a propensity for apathy. Two hundred and nineteen high school students were participated in this research. We assumed time management (TM) and future prospects (self-fulfillment, goal-directedness, and hopefulness) would be preventive factors against apathetic tendencies for them. The study findings indicate that self-fulfillment may significantly reduce apathy, with hopefulness also contributing to reducing apathy. Additionally, the characteristics of apathy tendency, specifically lack of self, were found to be differently related to students' TM skills. In other words, the findings suggest that goal-directedness may alleviate apathy among students struggling with TM. kn-abstract=@•s“oZ‚̎傽‚é—vˆö‚Ì1ˆÊ‚Íu–³‹C—ÍE•sˆÀv‚Å40.0%‚ðè‚ß‚éi•¶•”‰ÈŠwÈC2023jB‚±‚Ì‚±‚Æ‚ÍC•s“oZ‚Å‚È‚¢¶“k‚Ì’†‚É‚àC–³‹C—Í‚ðŠ´‚¶‚Ä‚¢‚鶓k‚ª‚©‚È‚è‚¢‚邱‚Æ‚ðŽ¦´‚µ‚Ä‚¢‚éB‚»‚±‚Å–{Œ¤‹†‚ÍC‚Z¶‚Ì–³‹C—Í‚Æ‚»‚Ì—\–h‚ɂ‚¢‚ÄŒŸ“¢‚·‚éB–³‹C—Í‚ÍC‘åŠw¶‚ð‘ÎۂɃAƒpƒV[ŒXŒü‚Æ‚µ‚ÄŒŸ“¢‚³‚ê‚Ä‚«‚½B‚»‚±‚Å‚Z¶‚Ì–³‹C—Í‚ðƒAƒpƒV[ŒXŒü‚Æ‚µ‚Ä‘¨‚¦C‰Á‚¦‚Ä‚»‚ê‚ð—\–h‚·‚é‚à‚̂ɂ‚¢‚Ä‚à•¹‚¹‚ÄŒŸ“¢‚µ‚½B—\–h–@‚ÌŒó•â‚Æ‚µ‚ÄCƒ^ƒCƒ€ƒ}ƒlƒWƒƒ“ƒgiˆÈ‰ºCTMj‚Æ«—ˆ“W–]iŒ»Ý‚Ì[ŽÀŠ´E–Ú•WŽwŒü«EŠó–]j‚ð‘z’肵C‚Z¶219–¼‚ð‘ÎÛ‚ÉC‚±‚ê‚ç‚ÌŠÖŒW‚ðŒŸ“¢‚µ‚½B•ªÍ‚ÌŒ‹‰ÊC–³‹C—Í‚ð’ጸ‚·‚é‚Ì‚ÍCŒ»Ý‚Ì[ŽÀŠ´CŠó–]‚Å‚ ‚èC“Á‚É‘OŽÒ‚ª—LŒø‚Å‚ ‚é‰Â”\«‚ðŽ¦‚¹‚½Bˆê•û‚ÅCƒAƒpƒV[ŒXŒü‚ÌŽ©•ª‚Ì‚È‚³‚Å‚ÍCTM ‚̃^ƒCƒv‚É‚æ‚Á‚ĈقȂéŠÖŒW‚ª‚Ý‚ç‚ꂽB‚‚܂èCTM ‚ª‹êŽè‚ȶ“k‚Å‚ÍCŠó–]‚æ‚è‚àC–Ú‘O‚Ì–Ú•W‚É–Ú‚ðŒü‚¯‚邱‚Æ‚ª–³‹C—Í‚ð’ጸ‚Å‚«‚é‰Â”\«‚ªŽ¦´‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=ASADAAsuka en-aut-sei=ASADA en-aut-mei=Asuka kn-aut-name=–ƒ“c–¾“ú kn-aut-sei=–ƒ“c kn-aut-mei=–¾“ú aut-affil-num=1 ORCID= en-aut-name=AOKITazuko en-aut-sei=AOKI en-aut-mei=Tazuko kn-aut-name=–ؑ½ŽõŽq kn-aut-sei=Â–Ø kn-aut-mei=‘½ŽõŽq aut-affil-num=2 ORCID= affil-num=1 en-affil=KANKO GAKUSEIFUKU CO., LTD. kn-affil=›ŒöŠw¶•ž affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ@‹³Žö en-keyword=‚Z¶ (High School Students) kn-keyword=‚Z¶ (High School Students) en-keyword=–³‹C—Í kn-keyword=–³‹C—Í en-keyword=ƒAƒpƒV[ŒXŒü (Apathy tendency) kn-keyword=ƒAƒpƒV[ŒXŒü (Apathy tendency) en-keyword=ƒ^ƒCƒ€ƒ}ƒlƒWƒƒ“ƒg (Time Management) kn-keyword=ƒ^ƒCƒ€ƒ}ƒlƒWƒƒ“ƒg (Time Management) en-keyword=«—ˆ“W–] (Future Prospect) kn-keyword=«—ˆ“W–] (Future Prospect) en-keyword=Prevention kn-keyword=Prevention END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=179 end-page=190 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Current Trends and Future Issues Related to Songfs speed in the Preschool-Elementary Cooperated Education Research kn-title=—cŽ™‰Ì¥‹È‚Ì‘¬“xŠ´‚ÌŒXŒü‚Ɖۑè en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–{Œ¤‹†‚Å‚ÍC‰¹Šy‹³ˆç“IŠÏ“_‚©‚ç—cŽ™‰Ì¥‹È‚Ì‘I’è‚Ì‚ ‚è•û‚ðŒŸ“¢‚µ‚½B‚»‚ÌÛC¬ŠwZ‚̉¹Šy‹³ˆç‚ʼn̥‹¤’ʉۑè‚Æ‚µ‚Ä‹“‚°‚ç‚ê‚Ä‚«‚½‹³Þ‚ð”äŠr‘ÎÛ‚Æ‚µC‚»‚ÌŒXŒü‚Ɖۑè‚ðlŽ@‚·‚éB‚P‚–ڂ͋Ȃ̑¬“xŠ´‚É‚¨‚¢‚ĉ̥‹¤’Ê‹³Þ‚Æ‘I’è•p“x‚Ì‚‚¢—cŽ™‰Ì¥‹È‚Ì•½‹Ï“I‚È‘¬“x‚É‚¨‚¢‚ÄC‚Ç‚Ì’ö“x‚Ì·‚ª‚ ‚é‚Ì‚©‚Æ‚¢‚¤’²¸‚ðs‚Á‚½B‚Q‚–ڂÍC—c’t‰€‚ƬŠwZ‰¹Šy‰È‚Å‹¤’Ê‚µ‚Ä—p‚¢‚ç‚ê‚鋳ދȂÌì‹È‚³‚ꂽ”N‘ã‚̈Ⴂ‚ɂ‚¢‚Ä–¾‚ç‚©‚É‚µ‚½B‚±‚Ì‚Q‚‚̒²¸‚ð—p‚¢‚ÄC‰Ì¥‹¤’ʉۑè‚É‘I’肳‚ê‚Ä‚¢‚é‹È‚Ì‘¬“xŠ´‚©‚猻‘ã‚ÌŽq‚Ç‚à‚̉̂̑¬“xŠ´‚ÌŒXŒü‚𖾂炩‚É‚µ‚½B‚±‚ÌŒ‹‰Ê‚©‚ç—c’t‰€‹³ˆç‚É‚¨‚¯‚é—cŽ™‰Ì¥‹È‚̃`ƒƒ[ƒg‚ð쬂·‚邱‚Æ‚É‚æ‚Á‚ÄC“`““I‚ɉ̂¢Œp‚ª‚ê‚Ä‚«‚½—cŽ™‰Ì¥‹È‚ÌÄl‚̉”\«‚ðŽ¦‚µ‚½B en-copyright= kn-copyright= en-aut-name=TAKASUHiromi en-aut-sei=TAKASU en-aut-mei=Hiromi kn-aut-name=ûü{—T”ü kn-aut-sei=ûü{ kn-aut-mei=—T”ü aut-affil-num=1 ORCID= affil-num=1 en-affil=Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=—c•Û¬˜AŒg (Preschool-elementary cooperation) kn-keyword=—c•Û¬˜AŒg (Preschool-elementary cooperation) en-keyword=Žq‹Ÿ‚̉̂̑¬“xŠ´ (Childrenfs Song speed) kn-keyword=Žq‹Ÿ‚̉̂̑¬“xŠ´ (Childrenfs Song speed) en-keyword=Žq‹Ÿ‚̉̕¶‰» (Childrenfs singing culture) kn-keyword=Žq‹Ÿ‚̉̕¶‰» (Childrenfs singing culture) en-keyword=“`“‰¹Šy (Japanese traditional song materials) kn-keyword=“`“‰¹Šy (Japanese traditional song materials) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=163 end-page=177 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Climate and Songs of Spring/May Around Germany (Part ‡U): A Report of an Interdisciplinary Lesson Practice at the University Leading to the Understanding of Heterogeneous Others kn-title=ƒhƒCƒc•t‹ß‚ÌtE‚TŒŽ‚Ì‹CŒó‚ƉÌi‚»‚Ì‚QjFˆÙŽ¿‚È‘¼ŽÒ‚Ö‚Ìo‰ï‚¢‚𑣂·‘åŠw‚Å‚ÌŠwÛ“IŽö‹Æ‚ÌŽÀ‘H en-subtitle= kn-subtitle= en-abstract=An interdisciplinary lesson practice for the university students leading to the understanding of heterogeneous others was made on a topic of climate and songs of "spring/May" around Germany, as a continuing study of Kato et al. (2023b). In the lesson practice, details of the climate and seasonal cycle around Germany, in association with the seasonal feeling of the special season May, were firstly presented. Then, several German lieder, a film music, etc. were appreciated, paying attention to the relation between expressions of the songs and their climate backgrounds. It seems that the students were able to realize the characteristic expressions of the songs relating to the seasonal feeling of "the special season May" around Germany, mainly from the song lyrics, although how to promote further the students' deepening of such perception including musical expressions themselves is a remaining problem. kn-abstract=@ƒhƒCƒc•t‹ß‚ÌutE5ŒŽv‚Ì‹CŒó‚Ɖ̂̕\Œ»‚ÌŠwÛ“IŠwK‚ð’Ê‚µ‚ÄuˆÙŽ¿‚È‘¼ŽÒv‚Ö‚Ìo‰ï‚¢‚𑣂·‹³‰È‰¡’f“IŽö‹Æ‚ð‘åŠw‚Ås‚Á‚½BŽö‹Æ‚Å‚ÍCƒhƒCƒc•t‹ß‚É‚¨‚¯‚éutE5ŒŽv‚Ì‹Gߊ´‚Ì2‚‚̑¤–ÊC‚·‚È‚í‚¿uŒµ‚µ‚¢“~‚ðŒo‚Ä„‚è—ˆ‚é“Á•Ê‚ÈŠì‚Ñv‚âu‚·‚®‚ɉ߂¬‹Ž‚鎊•Ÿ‚ÌuŠÔ‚Ì™R‚³v‚ÉŠÖ˜A‚µ‚½‹CŒó‚Ì“Á’¥‚ðu‹`‚·‚é‚Æ‹¤‚ÉC‚»‚ê‚ç‚Ì‹Gߊ´‚ª•\Œ»‚³‚ꂽƒhƒCƒc‰Ì‹È‚â‰f‰æs‰ï‹c‚Í—x‚ét‚ÌŽå‘è‰Ìq‚½‚¾ˆê“x‚¾‚¯r“™‚ÌŠÓÜ‚ðs‚¢Cì•i‚Ì”wŒi‚É‚ ‚é‹CŒó‚Ɖ¹Šy•\Œ»‚ÌŠÖ‚è‚ɃAƒvƒ[ƒ`‚µ‚½B‚»‚ÌŒ‹‰ÊCì•i‚̉̎Œ‚ðŽå‚Ȏ肪‚©‚è‚ÉC‹CŒó‚â‹Gߊ´‚Ɖ¹Šy•\Œ»‚ÌŠÖ‚è‚ðŠT‚Ë‘¨‚¦‚邱‚Æ‚ª‚Å‚«‚½B]‚Á‚ÄC–{ŽÀ‘H‚ªuˆÙŽ¿‚È‘¼ŽÒv‚Ì‘¶Ý‚ðŽÀŠ´‚·‚é‹@‰ï‚ɂȂ蓾‚½‚Æ‚¢‚¦‚éBˆê•ûCu5ŒŽv‚Æ‚¢‚¤ˆêŒê‚É‹Ãk‚³‚ꂽƒhƒCƒc•t‹ß‚È‚ç‚Å‚Í‚Ì[‚¢“à—e‚ðu‰ä‚ªŽ–v‚Æ‚µ‚Ä‚æ‚è‹­‚­ŽÀŠ´‚·‚邽‚ß‚É‚ÍC‰ÌŽŒ‚Í‚à‚Æ‚æ‚艹Šy“I•\Œ»‚Æ‚Ì—‚Ý‚ðˆÓŽ¯‚µ‚½‘¨‚¦•ûC’ñŽ¦‚Ì•K—v«‚ªŽ¦´‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=KATOKuranoshin en-aut-sei=KATO en-aut-mei=Kuranoshin kn-aut-name=‰Á“¡“àåUi kn-aut-sei=‰Á“¡ kn-aut-mei=“àåUi aut-affil-num=1 ORCID= en-aut-name=NAGAOKAIsao en-aut-sei=NAGAOKA en-aut-mei=Isao kn-aut-name=’·‰ªŒ÷ kn-aut-sei=’·‰ª kn-aut-mei=Œ÷ aut-affil-num=2 ORCID= en-aut-name=KATOHaruko en-aut-sei=KATO en-aut-mei=Haruko kn-aut-name=‰Á“¡°Žq kn-aut-sei=‰Á“¡ kn-aut-mei=°Žq aut-affil-num=3 ORCID= en-aut-name=OTANIKazuo en-aut-sei=OTANI en-aut-mei=Kazuo kn-aut-name=‘å’J˜a’j kn-aut-sei=‘å’J kn-aut-mei=˜a’j aut-affil-num=4 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=3 en-affil=Faculty of Education, Gifu Shotoku Gakuen University (Former affiliation) kn-affil=Œ³@Šò•Œ¹“¿Šw‰€‘åŠw‹³ˆçŠw•” affil-num=4 en-affil=TV Setouchi Broadcasting Co., LTD. kn-affil=ƒeƒŒƒr‚¹‚Æ‚¤‚¿iŠ”j en-keyword=‹CŒó‚Ɖ¹Šy (Climate and music) kn-keyword=‹CŒó‚Ɖ¹Šy (Climate and music) en-keyword=ƒhƒCƒc•t‹ß‚ÌtE5ŒŽ‚Ì‹CŒó‚Æ‹Gߊ´ (Climate and seasonal feeling in spring/May around Germany) kn-keyword=ƒhƒCƒc•t‹ß‚ÌtE5ŒŽ‚Ì‹CŒó‚Æ‹Gߊ´ (Climate and seasonal feeling in spring/May around Germany) en-keyword=ESD ‹³Žt‹³ˆç (Teacher education on ESD) kn-keyword=ESD ‹³Žt‹³ˆç (Teacher education on ESD) en-keyword=ˆÙŽ¿‚È‘¼ŽÒ‚Ö‚Ì—‰ð (Understanding of heterogeneous others) kn-keyword=ˆÙŽ¿‚È‘¼ŽÒ‚Ö‚Ì—‰ð (Understanding of heterogeneous others) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=147 end-page=161 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Teacher Response Processes to Behavioral Problems in Students with Mild Intellectual Disabilities: An Examination Based on Practices at High School Division of Special Needs School A kn-title=Œy“x’m“IáŠQ‚Ì‚ ‚鶓k‚Ìs“®–â‘è‚Ö‚Ì‹³ˆõ‘Ήž‰ß’ö@\A ’m“IáŠQ“Á•ÊŽx‰‡ŠwZ‚“™•”‚Å‚ÌŽÀ‘HŒŸ“¢‚ð’Ê‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract=The purpose of this study is to clarify the framework for teachers when addressing behavioral problems of students in the high school division of a special needs school for students with intellectual disabilities. The methodology involved conducting interviews with four experienced teachers from School A, a special needs school for students with intellectual disabilities, which had successfully navigated difficult periods due to challenges in student guidance. Qualitative analysis was conducted using the Modified Grounded Theory Approach (M-GTA). As a result, two core categories emerged: "Building relationships with individuals that foster a sense of security" and "Aiming for shared and unified approaches." Sixteen concepts were generated. When faced with behavioral problems, teachers focused on "Building relationships with individuals that foster a sense of security" as the axis for responding to students, while behind the scenes the teachers worked collectively toward "Aiming for shared and unified approaches." Finally, based on the framework clarified in this study, a hierarchical, comprehensive support system, including individualized support, was proposed. kn-abstract=@–{Œ¤‹†‚Ì–Ú“I‚ÍC’m“IáŠQ“Á•ÊŽx‰‡ŠwZ‚“™•”‚ÉÝЂ·‚鶓k‚Ìs“®–â‘è‚É’…–Ú‚µCŠwZŒ»ê‚Å‹³ˆõ‚ª“K؂ɑΉž‚·‚éۂ̘g‘g‚݂𖾂炩‚É‚·‚邱‚Æ‚Å‚ ‚éB‚»‚Ì•û–@‚Æ‚µ‚ÄC¶“kŽw“±ã‚̉ۑè‚ð——R‚Æ‚·‚鋳ˆç¢“ïŠú‚ðæ‚è‰z‚¦‚½A ’m“IáŠQ“Á•ÊŽx‰‡ŠwZ‚“™•”‚ÉŠ‘®‚µ‚Ä‚¢‚½ŒoŒ±–L•x‚È‹³ˆõ4–¼‚É–ÊÚ’²¸‚ðŽÀŽ{‚µCM-GTA ‚ÌŽè–@‚ð‰‡—p‚µ‚½Ž¿“I•ªÍ‚ðs‚Á‚½B‚»‚ÌŒ‹‰ÊCyˆÀSŠ´‚ð¶‚ތ‚Ƃ̊֌W‚­‚èz‚Æy‘Ήž•û–@‚Ì‹¤—L‚Æ“ˆê‰»‚ð–ÚŽw‚·zŠÖŒW«‚ªƒRƒAEƒJƒeƒSƒŠ[‚ƈʒu‚«C16‚Ì”ŠT”O‚𶬂µ‚½Bs“®–â‘è‚É’¼–Ê‚µ‚½‹³ˆõ‚ÍC¶“k‚ɑ΂µ‚Ä‚ÍyˆÀSŠ´‚ð¶‚ތ‚Ƃ̊֌W‚­‚èz‚ð‘Ήž‚ÌŽ²‚Æ‚µC‚»‚Ì”wŒã‚Å‚ÍŠwZ‚Æ‚µ‚Äy‘Ήž•û–@‚Ì‹¤—L‚Æ“ˆê‰»‚ð–ÚŽw‚·z‚½‚ß‚Ì“®‚«‚ð‚µ‚Ä‚¢‚½BÅŒã‚ÉC–{Œ¤‹†‚Å–¾‚ç‚©‚Æ‚È‚Á‚½‘Ήž‚̘g‘g‚݂ɂ‚¢‚ÄlŽ@‚µ‚½ŠÏ“_‚©‚çCŒÂ•Ê‚ÌŽžŠÔ‚ðŠÜ‚ÞŠK‘w«‚Ì‚ ‚é•ïŠ‡“I‚ÈŽx‰‡ƒVƒXƒeƒ€‚ðˆê‚‚̒ñˆÄ‚Æ‚µ‚½B en-copyright= kn-copyright= en-aut-name=TOKIMITSUHideaki en-aut-sei=TOKIMITSU en-aut-mei=Hideaki kn-aut-name=ŽžŒõG–¾ kn-aut-sei=ŽžŒõ kn-aut-mei=G–¾ aut-affil-num=1 ORCID= en-aut-name=MIYAZAKIYoshio en-aut-sei=MIYAZAKI en-aut-mei=Yoshio kn-aut-name=‹{ú±‘P˜Y kn-aut-sei=‹{ú± kn-aut-mei=‘P˜Y aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Education (Professional Degree Course), Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@¶ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=‚“™•” (High school division) kn-keyword=‚“™•” (High school division) en-keyword=Œy“x’m“IáŠQ (Mild intellectual disabilities) kn-keyword=Œy“x’m“IáŠQ (Mild intellectual disabilities) en-keyword=”­’BáŠQ (Developmental disorders) kn-keyword=”­’BáŠQ (Developmental disorders) en-keyword=s“®–â‘è (Behavioral problems) kn-keyword=s“®–â‘è (Behavioral problems) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=133 end-page=145 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Image of Mushroom Created by Junior High School Science Textbooks: Suggestions for Learning about Mushroom from Diachronic Surveys kn-title=’†ŠwZ—‰È‹³‰È‘‚ª‚‚­‚èã‚°‚Ä‚«‚½‚«‚Ì‚±‘œ@\’ÊŽž“I’²¸‚©‚瓾‚é‚«‚Ì‚±‚ð„‚éŠwK‚Ö‚ÌŽ¦´\ en-subtitle= kn-subtitle= en-abstract=@In this paper, we examined the image of mushroom in postwar junior high school science textbooks from four perspectives: (1) which species of mushroom were covered, (2) whether they were classified as plants or not, (3) what makes up the body of a mushroom, and (4) how they functioned in an ecosystem. The 47 species were identified through a periodic survey. Although a total of 47 species have appeared in science textbooks, we pointed out that in recent years, the focus has shifted to the role of mushroom as decomposers, rather than to species awareness. We also pointed out that although mycorrhizal fungi have been discussed in textbooks, there was no reference to the perspective in a plant-fungal symbiosis, which raises the possibility of developing learning that aims to understand symbiosis/interactions within a nature ecosystem. kn-abstract=@–{e‚Å‚ÍCíŒã’†ŠwZ—‰ÈŒŸ’苳‰È‘‚É‚¨‚¯‚é‚«‚Ì‚±‚̈µ‚í‚ê•ûC‚·‚È‚í‚¿ŠwKŽÒ‚ªŽó‚¯Žæ‚邱‚Æ‚É‚È‚é‚«‚Ì‚±‘œ‚ɂ‚¢‚ÄC‡@‚ǂ̂悤‚È‚«‚Ì‚±‚ªˆµ‚í‚ê‚Ä‚«‚½‚Ì‚©C‡AA•¨‚É•ª—Þ‚³‚ê‚Ä‚¢‚é‚©”Û‚©C‡B‚«‚Ì‚±‚Ì‚©‚炾‚͉½‚ÅŒ`¬‚³‚ê‚Ä‚¢‚é‚Ì‚©C‡C¶‘ÔŒn‚É‚¨‚¯‚é“­‚«‚ÌŽl‚‚̊ϓ_‚©‚çC’ÊŽž“I‚È’²¸‚É‚æ‚Á‚Ä–¾‚ç‚©‚É‚µ‚½B‘S47Ží‚ª‚±‚ê‚Ü‚Å‚Ì—‰È‹³‰È‘‚Å“oꂵ‚Ä‚«‚½‚ªC‹ß”N‚ÍŽí‚ւ̈ӎ¯‚Æ‚¢‚¤‚æ‚è‚àC‚«‚Ì‚±‚ª•ª‰ðŽÒ‚Æ‚µ‚Ä‚Ì–ðŠ„‚ðŽ‚‚±‚Æ‚É‚Ì‚ÝÅ“_‚ª“–‚Ä‚ç‚ê‚Ä‚«‚Ä‚¢‚邱‚Æ‚ðŽw“E‚µ‚½B‚Ü‚½C‚±‚ê‚Ü‚Å‹³‰È‘‚É‚¨‚¢‚Ä‚Í‹Ûª«‚Ì‚«‚Ì‚±Ž©‘̂ɂ‚¢‚ÄŽæ‚èã‚°‚ç‚ê‚‚‚àC‚»‚̶‘ÔŒn‚É‚¨‚¯‚é‘Š—˜‹¤¶‚ÌŠÏ“_‚Ö‚ÌŒ¾‹y‚Í‚È‚¢‚±‚Æ‚©‚çC‘Š—˜‹¤¶‚Ì—‰ð‚ð–ÚŽw‚·ŠwK‚ÌŠJ”­‚ª‰Â”\«‚Æ‚µ‚Ä•‚‚©‚Ñオ‚Á‚Ä‚­‚邱‚Æ‚àŽw“E‚µ‚½B en-copyright= kn-copyright= en-aut-name=TAKAGIRisa en-aut-sei=TAKAGI en-aut-mei=Risa kn-aut-name=ûü–Ø—¢Ê kn-aut-sei=ûü–Ø kn-aut-mei=—¢Ê aut-affil-num=1 ORCID= en-aut-name=IKEDAMasafumi en-aut-sei=IKEDA en-aut-mei=Masafumi kn-aut-name=’r“c‹§Žj kn-aut-sei=’r“c kn-aut-mei=‹§Žj aut-affil-num=2 ORCID= en-aut-name=YAMAMOTOMasaya en-aut-sei=YAMAMOTO en-aut-mei=Masaya kn-aut-name=ŽR–{«–ç kn-aut-sei=ŽR–{ kn-aut-mei=«–ç aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Education (Professional Degree Corse), Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@¶ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=3 en-affil=Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@ŠwZ‹³ˆçŒ¤‹†‰È en-keyword=‹Û—Þ (Fungus) kn-keyword=‹Û—Þ (Fungus) en-keyword=‹Ûª‹Û (Mycorrhizal Fungi) kn-keyword=‹Ûª‹Û (Mycorrhizal Fungi) en-keyword=•…¶‹Û (Saprobic Fungi) kn-keyword=•…¶‹Û (Saprobic Fungi) en-keyword=‘Š—˜‹¤¶ (Symbiosis) kn-keyword=‘Š—˜‹¤¶ (Symbiosis) en-keyword=‹³ÞŽj (History of teaching materials) kn-keyword=‹³ÞŽj (History of teaching materials) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=119 end-page=132 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Development of Thoughts on the Effective Use of School Libraries and Collaboration with Teacher-Librarians and School Librarians in Japanese Language Arts: From a Survey of the Journal Kyoiku Kagaku Kokugo Kyoiku kn-title=ŠwZ}‘ŠÙ‚ÌŠˆ—p‚ÆŽi‘‹³—@EŠwZŽi‘‚Æ‚Ì‹¦“­‚ð‚ß‚®‚鑌ꋳˆçŽv’ª‚Ì“WŠJ@\w‹³ˆç‰ÈŠw‘Œê‹³ˆçxŽ‚Ì’²¸‚©‚ç\ en-subtitle= kn-subtitle= en-abstract=@School libraries are mentioned by government guidelines for teaching, and it is also closely related to Japanese language arts. Previous studies have reported the necessity of collaboration with teacher-librarians and school librarians. However, there has been no study of what kind of collaboration has been conducted in Japanese language arts to date. Therefore, the purpose of this study is to examine how school libraries are utilized in Japanese language arts based on a survey of educational journals, and to organize references to teacher-librarians and school librarians. As a result, we pointed out that while school libraries have been utilized in Japanese language arts in elementary and junior high schools, the collaboration with teacher-librarians and school librarians may not have been focused on, and that the reason for this is the lack of human resources, while some valuable collaborations can be found. kn-abstract=@ŠwZ}‘ŠÙ‚ÍCŠwKŽw“±—v—Ì‚Å‚àG‚ê‚ç‚ê‚Ä‚¨‚èC‘Œê‰È‚Æ‚ÌŠÖ˜A‚à[‚¢B‚Ü‚½æsŒ¤‹†‚Å‚ÍCŽi‘‹³—@‚âŠwZŽi‘‚Æ‚Ì‹¦“­‚Ì•K—v«‚ª‘i‚¦‚ç‚ê‚Ä‚¢‚éB‚µ‚©‚µ‚±‚ê‚Ü‚Å‚Ì‘Œê‹³ˆç‚Å‚ÍC‚ǂ̂悤‚È‹¦“­‚ª‚È‚³‚ê‚Ä‚¢‚½‚Ì‚©‚Æ‚¢‚¤ŒŸ“¢‚ª‚È‚³‚ê‚Ä‚¢‚È‚¢B‚»‚±‚ÅC–{Œ¤‹†‚Å‚ÍC‹³ˆçŽGŽ‚Ì’²¸‚ð‚à‚Æ‚ÉC‘Œê‰È‚É‚¨‚¢‚Ä‚ÍCŠwZ}‘ŠÙ‚ª‚ǂ̂悤‚ÉŠˆ—p‚³‚ê‚Ä‚«‚½‚Ì‚©CŽi‘‹³—@‚âŠwZŽi‘‚Æ‚Ì‹¦“­‚͂ǂ̂悤‚È‘Ô“x‚ª‚Æ‚ç‚ê‚Ä‚«‚½‚Ì‚©‚𖾂炩‚É‚·‚邱‚Æ‚ð–Ú“I‚Æ‚µ‚½B’²¸‚Å‚ÍC}‘ŠÙ‚ÉŒ¾‹y‚µ‚Ä‚¢‚é˜_•¶‚âŠwZ}‘ŠÙ‚ðŠˆ—p‚µ‚½ŽÀ‘HEŽw“±—á‚ð’Šo‚µC•ªÍ‚µ‚½BŽÀ‘HEŽw“±—á‚Ì•ªÍ‚©‚ç‚ÍC¬E’†ŠwZ‚Ì‘Œê‰È‚É‚¨‚¢‚ÄŠwZ}‘ŠÙ‚ÍŠˆ—p‚³‚ê‚Ä‚«‚½ˆê•û‚ÅCŽi‘‹³—@‚âŠwZŽi‘‚Æ‚Ì‹¦“­‚É‚Í’…–Ú‚ª‹y‚ñ‚Å‚¢‚È‚¢ó‹µ‚ª–¾‚ç‚©‚É‚È‚Á‚½B‚Ü‚½CŽi‘‹³—@‚âŠwZŽi‘‚ÉŠÖ‚·‚錾‹y‚©‚ç‚ÍCl“IƒŠƒ\[ƒX‚É‚»‚ÌŒ´ˆö‚ð‹‚ß‚éŽv’ª‚ª‰M‚¦‚½‚à‚Ì‚ÌC‰¿’l‚ ‚鋦“­‚àŒ©Žó‚¯‚ç‚ê‚邱‚Æ‚ðŽw“E‚µ‚½B en-copyright= kn-copyright= en-aut-name=SAISHOYumi en-aut-sei=SAISHO en-aut-mei=Yumi kn-aut-name=Å‘Š—L–¢ kn-aut-sei=Å‘Š kn-aut-mei=—L–¢ aut-affil-num=1 ORCID= en-aut-name=IKEDAMasafumi en-aut-sei=IKEDA en-aut-mei=Masafumi kn-aut-name=’r“c‹§Žj kn-aut-sei=’r“c kn-aut-mei=‹§Žj aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of EducationiProfessional Degree CorsejCOkayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@¶ affil-num=2 en-affil=Faculty of EducationCOkayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=ŽGŽ’²¸ (survey of journals) kn-keyword=ŽGŽ’²¸ (survey of journals) en-keyword=“Ç‘Žw“± (reading instruction) kn-keyword=“Ç‘Žw“± (reading instruction) en-keyword=’T‹†“I‚ÈŠwK (inquiry-based learning) kn-keyword=’T‹†“I‚ÈŠwK (inquiry-based learning) en-keyword=‘Œê‹³ˆçŽj (history of Japanese Language Arts) kn-keyword=‘Œê‹³ˆçŽj (history of Japanese Language Arts) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=107 end-page=118 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of Practical Results of the Liberal Arts Education Class gCreativity in Lifeh at Okayama University ‡V kn-title=‘åŠw‹³—{‹³ˆç‚É‚¨‚¯‚é‘n‘¢«‚ðdŽ‹‚µ‚½’T‹†Œ^Žö‹Æ‚Ì•]‰¿@‰ªŽR‘åŠw‹³—{‹³ˆç‰È–Úu¶Šˆ‚Ì’†‚Ì‘n‘¢«v‚ÌŽÀ‘HŒ‹‰Ê‚Ì•ªÍ‡V en-subtitle= kn-subtitle= en-abstract=@Since 2022, in the liberal arts education course gModernity and Society,h a class entitled gCreativity in Lifeh has been implemented, in which students propose gOkadai Goodsh using gcolorh as the theme. According to the questionnaires conducted before and after the class, the students regarded creativity as gimportant for me,h were ginterested in communicating with others and engaging in creative activities,h and changed their evaluation to a positive one, saying gI am creativeh after the class. This class was found to be highly effective in promoting gawareness of one's own existence to think, feel, and judge independently and interactively. We believe that the main theme and the content of the inquiry activities in this class were suitable for the inquiry-based learning of university students. kn-abstract=@2022”N‚æ‚苳—{‹³ˆç‰È–ÚuŒ»‘ã‚ƎЉïv‚É‚¨‚¢‚ÄCuFv‚ðŽå‘è‚É‚µ‚Äu‰ª‘åƒOƒbƒYv‚Ì’ñˆÄ‚ðs‚¤’T‹†Œ^Žö‹Æu¶Šˆ‚Ì’†‚Ì‘n‘¢«v‚ðŠJu‚µ‚Ä‚¢‚éBŽö‹Æ‘OŒã‚̃Aƒ“ƒP[ƒg‚É‚æ‚é‚ÆCŠw¶‚ÍuŽ©•ª‚É‚Æ‚Á‚Ä‘n‘¢«‚Íd—vv‚Æ‘¨‚¦Cu‘¼ŽÒ‚ƃRƒ~ƒ…ƒjƒP[ƒVƒ‡ƒ“‚ðŽæ‚è‚È‚ª‚ç‘n‘¢“I‚ÈŠˆ“®‚ð‚·‚é‚±‚Æ‚É‹»–¡v‚ª‚ ‚èCŽö‹ÆŒã‚ÍuŽ©•ª‚Ì‚±‚Æ‚ð‘n‘¢“I‚Å‚ ‚év‚Æm’è“I‚È•]‰¿‚Æ‚È‚Á‚Ä‚¢‚½B‚±‚ÌŽö‹Æ‚ÍuŽå‘Ì“IC‘Θb“I‚Él‚¦CŠ´‚¶C”»’f‚·‚鎩•ªŽ©g‚Ì‘¶Ý‚ðˆÓŽ¯‚·‚邱‚Æv‚𑣂·Œø‰Ê‚ª‘å‚«‚¢‚±‚Æ‚ª•ª‚©‚Á‚½B‚±‚Ì‚R”NŠÔ‚ÌŽÀ‘H‚ÍCŽåŽ²‚Æ‚È‚éƒe[ƒ}‚Æ’T‹†Šˆ“®‚Ì“à—e‚ª‘åŠw¶‚Ì’T‹†“I‚ÈŠw‚Ñ‚É“K‚µ‚½‚à‚Ì‚Å‚ ‚Á‚½‚Æl‚¦‚Ä‚¢‚éB en-copyright= kn-copyright= en-aut-name=SHINOHARAYoko en-aut-sei=SHINOHARA en-aut-mei=Yoko kn-aut-name=ŽÂŒ´—zŽq kn-aut-sei=ŽÂŒ´ kn-aut-mei=—zŽq aut-affil-num=1 ORCID= en-aut-name=INADAYoshihiko en-aut-sei=INADA en-aut-mei=Yoshihiko kn-aut-name=ˆî“c‰À•F kn-aut-sei=ˆî“c kn-aut-mei=‰À•F aut-affil-num=2 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=’T‹†Œ^Žö‹Æ kn-keyword=’T‹†Œ^Žö‹Æ en-keyword=‘n‘¢« (Creativity) kn-keyword=‘n‘¢« (Creativity) en-keyword=•¨—Šw (Physics) kn-keyword=•¨—Šw (Physics) en-keyword=”í•žŠw (Clothing) kn-keyword=”í•žŠw (Clothing) en-keyword=‰ª‘åƒOƒbƒY (Okadai-Goods) kn-keyword=‰ª‘åƒOƒbƒY (Okadai-Goods) en-keyword=ICT Šˆ—p (ICT) kn-keyword=ICT Šˆ—p (ICT) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=91 end-page=105 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Reflections of Early Care and Education Practitioners, as Indicated in the Content on the Care and Education of Kindergarten Children Published by Japanfs Ministry of Education, Culture, Sports, Science and Technology kn-title=—c’t‰€‚Ì•Ûˆç‘S‘Ì‚ÉŠÖ‚·‚镶•”‰ÈŠwÈŒö•\Ž‘—¿‚ÉŽ¦‚³‚ê‚Ä‚¢‚é•ÛˆçŽÒ‚ÌU‚è•Ô‚è‚ÌŽd•û‚ÌŒŸ“¢ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–{Œ¤‹†‚Å‚ÍC‚Ü‚¸C‰ä‚ª‘‚Ì•ÛˆçŽ{Ý‚É‚¨‚¯‚éƒJƒŠƒLƒ…ƒ‰ƒ€Eƒ}ƒlƒWƒƒ“ƒg‚ÉŠÖ‚·‚éæsŒ¤‹†‚ðŠTŠÏ‚µCƒJƒŠƒLƒ…ƒ‰ƒ€Eƒ}ƒlƒWƒƒ“ƒg‚ðŽÀŒ»‚·‚邽‚ß‚É•K—v‚ÈC•Ûˆç‚Ì–Ú•WE‚Ë‚ç‚¢E“à—e‚̘AŠÖ«‚ÌŠm•Û‚³‚ꂽ‘S‘Ì“IŒv‰æ‚Ì쬂ª¢“ï‚È󋵂ɂ ‚邱‚Æ‚ðŠm”F‚µ‚½B‘±‚¢‚ÄC•Ûˆç‚Ì–Ú•WE‚Ë‚ç‚¢E“à—e‚̘AŠÖ«‚ðŠm•Û‚·‚éã‚ÅC‚»‚Ì‚±‚Æ‚ð‰Â”\‚É‚·‚é•ÛˆçŽÒ‚ÌU‚è•Ô‚è‚ÌŽd•û‚ª•s‰ÂŒ‡‚ƂȂ邱‚Ƃ𓥂܂¦‚ÄC—c’t‰€‚Ì•Ûˆç‘S‘Ì‚ÉŠÖ‚·‚镶•”‰ÈŠwÈŒö•\Ž‘—¿‚ÉŽ¦‚³‚ê‚Ä‚¢‚éC•ÛˆçŽÒ‚ÌU‚è•Ô‚è‚Ì–Ú“ICŠÏ“_C•û–@‚ð’Šo‚µ®—‚µCŒŸ“¢‚µ‚½B‚»‚ÌŒ‹‰ÊC•ÛˆçŽÒ‚Ì’·Šú‚ÌU‚è•Ô‚è‚ÉŠÖ‚µ‚ÄŽ¦‚³‚ê‚Ä‚¢‚é‹Lq‚Å‚ÍC‹ï‘Ì«‚ª–R‚µ‚­C•Ûˆç‚Ì–Ú•WE‚Ë‚ç‚¢E“à—e‚̘AŠÖ«‚ÌŠm•Û‚³‚ꂽ’·ŠúŽw“±Œv‰æ‹y‚Ñ‘S‘Ì“IŒv‰æ‚ð쬂·‚éã‚ÅCŽÀ—p“I‚Å‚Í‚È‚¢‚±‚Ƃ𖾂炩‚É‚µ‚½B en-copyright= kn-copyright= en-aut-name=ARITASho en-aut-sei=ARITA en-aut-mei=Sho kn-aut-name=—L“cãÄ kn-aut-sei=—L“c kn-aut-mei=ãÄ aut-affil-num=1 ORCID= en-aut-name=YOKOMATSUTomoyoshi en-aut-sei=YOKOMATSU en-aut-mei=Tomoyoshi kn-aut-name=‰¡¼—F‹` kn-aut-sei=‰¡¼ kn-aut-mei=—F‹` aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Education, Okayama University (Masterfs Course) kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@¶ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=•ÛˆçŽÒ‚ÌU‚è•Ô‚è (reflections of early care and education practitioners) kn-keyword=•ÛˆçŽÒ‚ÌU‚è•Ô‚è (reflections of early care and education practitioners) en-keyword=—c’t‰€ (kindergarten) kn-keyword=—c’t‰€ (kindergarten) en-keyword=ƒJƒŠƒLƒ…ƒ‰ƒ€Eƒ}ƒlƒWƒƒ“ƒg (curriculum management) kn-keyword=ƒJƒŠƒLƒ…ƒ‰ƒ€Eƒ}ƒlƒWƒƒ“ƒg (curriculum management) en-keyword=•¶•”‰ÈŠwÈŒö•\Ž‘—¿ (the content on the care and education of kindergarten children published by Japanfs Ministry of Education, Culture, Sports, Science and Technology) kn-keyword=•¶•”‰ÈŠwÈŒö•\Ž‘—¿ (the content on the care and education of kindergarten children published by Japanfs Ministry of Education, Culture, Sports, Science and Technology) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=75 end-page=89 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Trends in Awareness of Earthquake Disaster Prevention among Students Aspiring to Become Childcare Providers kn-title=•ÛˆçŽÒŽu–]Šw¶‚Ì’nk–hЂɑ΂·‚éˆÓŽ¯‚ÌŒXŒü en-subtitle= kn-subtitle= en-abstract=@In recent years, under the growing sense of crisis about the possibility of a major earthquake in the Nankai Trough, etc., it has become necessary to have more awareness of earthquake disaster prevention and to take measures for disaster prevention regularly. The purpose of this study was to clarify the actual situation of students who aspire to become childcare providers to protect children's lives. As a result of a questionnaire survey, we found that their awareness of the danger of earthquakes tended to differ by grade level and that their understanding and knowledge of earthquake disaster prevention differed depending on their awareness of earthquake disaster prevention. In the future, it will be necessary to consider conducting evacuation drills in kindergartens or nursery schools and providing guidance on disaster prevention education in training programs for childcare providers. kn-abstract=@‹ß”NC“ìŠCƒgƒ‰ƒt‹‘å’nk‚â“sŽs’¼‰ºŒ^’nk‚ɑ΂·‚éŠë‹@Š´‚ª‚‚Ü‚é’†C’nk–hЂɑ΂·‚é‚‚¢ˆÓŽ¯‚ðŽ‚¿C•’i‚©‚ç–hЂɊւ·‚éŽæ‚è‘g‚Ý‚É“w‚߂邱‚Æ‚ª‹‚ß‚ç‚ê‚Ä‚¢‚éB–{Œ¤‹†‚Å‚ÍCŽq‚Ç‚à‚Ì–½‚ðŽç‚é•ÛˆçŽÒ‚ð–ÚŽw‚·Žu–]Šw¶‚ªC’nkЊQ‚ɑ΂·‚éˆÓŽ¯‚ð‚ǂ̂悤‚ÉŽ‚¿C’nk–hЂɊւ·‚é’mŽ¯‚â—‰ð‚ð‚Ç‚Ì’ö“x•ÛŽ‚µ‚Ä‚¢‚é‚Ì‚©‚ɂ‚¢‚ÄC‚»‚ÌŽÀ‘Ԃ𖾂炩‚É‚·‚邱‚Æ‚ð–Ú“I‚Æ‚µ‚½B•ÛˆçŽÒ—{¬Z‚S‘åŠw‚ÌŠw¶‚ɑ΂·‚鎿–⎆’²¸‚ðs‚Á‚½Œ‹‰ÊC’nk‚Ö‚ÌŠë‹@ˆÓŽ¯‚ªŠw”N‚É‚æ‚Á‚ĈقȂéŒXŒü‚É‚ ‚邱‚Æ‚âC’nk–hЂɊւ·‚éˆÓŽ¯‚Ì‚’á‚É‚æ‚Á‚ÄC’nk‚ɑ΂·‚é’mŽ¯‚â”FŽ¯‚̈Ⴂ‚ª‚ ‚邱‚Æ‚ª”»–¾‚µ‚½B¡ŒãC—cŽ™‹³ˆçE•ÛˆçŽ{Ý‚É‚¨‚¯‚é”ð“ïŒP—û‚ÌŽÀŽ{‚âC•ÛˆçŽÒ—{¬‰Û’ö‚É‚¨‚¢‚Ä–hЋ³ˆç‚ÉŠÖ‚·‚éŽw“±‚ðŒŸ“¢‚µ‚Ä‚¢‚­‚±‚Æ‚ª‹‚ß‚ç‚ê‚éB en-copyright= kn-copyright= en-aut-name=SATOHDaisuke en-aut-sei=SATOH en-aut-mei=Daisuke kn-aut-name=²“¡‘å‰î kn-aut-sei=²“¡ kn-aut-mei=‘å‰î aut-affil-num=1 ORCID= en-aut-name=TAKAHASHIKei en-aut-sei=TAKAHASHI en-aut-mei=Kei kn-aut-name=ûü‹´Œd kn-aut-sei=ûü‹´ kn-aut-mei=Œd aut-affil-num=2 ORCID= en-aut-name=BABANoriko en-aut-sei=BABA en-aut-mei=Noriko kn-aut-name=”nêŒPŽq kn-aut-sei=”nê kn-aut-mei=ŒPŽq aut-affil-num=3 ORCID= affil-num=1 en-affil=Faculty of Health and Welfare, Kawasaki University of Medical Welfare kn-affil=ìèˆã—ÕŸŽƒ‘åŠwˆã—ÕŸŽƒŠw•” affil-num=2 en-affil=Faculty of Childhood Education, Kurashiki Sakuyo University kn-affil=‚­‚炵‚«ì—z‘åŠwŽq‚Ç‚à‹³ˆçŠw•” affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=’nk–hÐ (earthquake disaster prevention) kn-keyword=’nk–hÐ (earthquake disaster prevention) en-keyword=•ÛˆçŽÒŽu–]Šw¶ (students aspiring to become childcare providers) kn-keyword=•ÛˆçŽÒŽu–]Šw¶ (students aspiring to become childcare providers) en-keyword=ˆÓŽ¯’²¸ (questionnaire survey) kn-keyword=ˆÓŽ¯’²¸ (questionnaire survey) en-keyword=Šë‹@ˆÓŽ¯ (sense of crisis) kn-keyword=Šë‹@ˆÓŽ¯ (sense of crisis) en-keyword=’nk–hЋ³ˆç (education for earthquake disaster prevention) kn-keyword=’nk–hЋ³ˆç (education for earthquake disaster prevention) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=59 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Career Years on the Coordination Behavior of Yogo Teachers kn-title=—{Œì‹³—@‚̃R[ƒfƒBƒl[ƒVƒ‡ƒ“s“®‚É‹y‚Ú‚·ƒLƒƒƒŠƒA”N”‚̉e‹¿ en-subtitle= kn-subtitle= en-abstract=The purpose of this study was to clarify the factors influencing coordination behavior of Yogo teachers and the relationship between the occurrence process of the factors and career years. The subjects analyzed were 695 persons working in public elementary and junior high schools. The effect of years of career was seen in the improvement of scale scores of factors related to the stages of coordination behavior and motivation, as well as subscale scores of the factors.
The relationship between the number of years of career and factors related to the generation process of coordination behavior suggested three characteristics. That is, (1) The establishment of a foundation for organizational support that starts from collaboration, due to the correlation between factors showing high subscale scores unaffected by the number of years of career, and (2) The correlation among factors of motivational factors whose subscale scores increase with the number of years of career, which leads to the promotion of individualized support efforts, and (3) Correlation between factors of leader recognition and individual support seen in the career category of 11 years or more, and which leads to the promotion of expansion to management of organizational support. kn-abstract=@–{Œ¤‹†‚Ì–Ú“I‚ÍC—{Œì‹³—@‚̃R[ƒfƒBƒl[ƒVƒ‡ƒ“s“®‚ɉe‹¿‚·‚é—vˆö‚â‚»‚̈öŽq‚ÌŒXŒü‚ðƒLƒƒƒŠƒA”N”‚©‚瑨‚¦C‚±‚ê‚ç‚ƃR[ƒfƒBƒl[ƒVƒ‡ƒ“s“®‚̶‹NƒvƒƒZƒX‚Æ‚ÌŠÖŒW‚ɂ‚¢‚Ä–¾‚ç‚©‚É‚·‚邱‚Æ‚Å‚ ‚Á‚½B•ªÍ‘ÎÛ‚ÍCŒö—§¬ŠwZE’†ŠwZ‹Î–±695–¼‚Æ‚µ‚½BƒLƒƒƒŠƒA”N”‚̉e‹¿‚ÍCƒR[ƒfƒBƒl[ƒVƒ‡ƒ“s“®‚Æ“®‹@‚¯‚Ì’iŠK‚ÉŠÖ‚í‚é—vˆö‚ÌŽÚ“x“¾“_‚âCˆöŽq‚̉ºˆÊŽÚ“x“¾“_‚ÌŒüã‚ÉŒ©‚ç‚ꂽB‚Ü‚½CƒLƒƒƒŠƒA”N”‚ƃR[ƒfƒBƒl[ƒVƒ‡ƒ“s“®‚̶‹NƒvƒƒZƒX‚ÉŠÖ‚í‚éˆöŽqŠÔ‚ÌŠÖŒW‚©‚ç‚ÍCi1jƒLƒƒƒŠƒA”N”‚ɉe‹¿‚³‚ê‚È‚¢‚‚¢‰ºˆÊŽÚ“x“¾“_‚ðŽ¦‚·ˆöŽqŠÔ‘ŠŠÖ‚É‚æ‚éC‹¦“­‚ð‹N“_‚É‚µ‚½‘gDŽx‰‡‚ÌŠî”Ղ­‚èCi2jƒLƒƒƒŠƒA”N”‚É‚æ‚艺ˆÊŽÚ“x“¾“_‚ª‚‚Ü‚é“®‹@‚¯—vˆö‚̈öŽqŠÔ‘ŠŠÖ‚É‚æ‚éCŒÂ•ÊŽx‰‡‚ÌŽæ‘g„i‚ւ̂‚Ȃª‚èCi3j11”NˆÈãƒLƒƒƒŠƒA‹æ•ª‚ÅŒ©‚ç‚ê‚郊[ƒ_[”F’m‚ƌ•ʎx‰‡‚̈öŽqŠÔ‘ŠŠÖC‹y‚Ñ‘gD“IŽx‰‡‚̃}ƒlƒWƒƒ“ƒg‚Ö‚ÌL‚ª‚èC‚Ì‚R‚‚̓Á’¥‚ð‚à‚‚±‚Æ‚ªŽ¦´‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=SUZUKIKaoru en-aut-sei=SUZUKI en-aut-mei=Kaoru kn-aut-name=—é–ØŒO kn-aut-sei=—é–Ø kn-aut-mei=ŒO aut-affil-num=1 ORCID= en-aut-name=MIMURAYukari en-aut-sei=MIMURA en-aut-mei=Yukari kn-aut-name=ŽO‘º—R—¢ kn-aut-sei=ŽO‘º kn-aut-mei=—R—¢ aut-affil-num=2 ORCID= affil-num=1 en-affil=Research student, United Graduate School of Education, Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw˜A‡‘åŠw‰@‹³ˆçŠwŒ¤‹†‰ÈŒ¤‹†¶ affil-num=2 en-affil=Graduate School of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=—{Œì‹³—@ (Yogo teacher) kn-keyword=—{Œì‹³—@ (Yogo teacher) en-keyword=ƒR[ƒfƒBƒl[ƒVƒ‡ƒ“s“® (coordination behavior) kn-keyword=ƒR[ƒfƒBƒl[ƒVƒ‡ƒ“s“® (coordination behavior) en-keyword=ŽÚ“x“¾“_ (scale score) kn-keyword=ŽÚ“x“¾“_ (scale score) en-keyword=‰ºˆÊŽÚ“x“¾“_ (subscale score‚’) kn-keyword=‰ºˆÊŽÚ“x“¾“_ (subscale score‚’) en-keyword=s“®‚̶‹NƒvƒƒZƒX (process of behavioral development) kn-keyword=s“®‚̶‹NƒvƒƒZƒX (process of behavioral development) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=45 end-page=58 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Childcare and Support in Nursery Schools for the Development of Geometry and Number Sense for Five-Year-Old Children kn-title=‚TÎŽ™‚ð‘ÎÛ‚Æ‚µ‚½”—ÊE}Œ`Š´Šo‚ðˆç‚ޕۈ犕ۈç‚ÌŽÀۂƉ‡•‚ÌÝ‚è•û en-subtitle= kn-subtitle= en-abstract=This study focuses on gthe interest and sense of numbers, geometry, and wordsh, which is regarded as one of "the Ideal Image by the End of Childhood". The focus is on 5-year-old pre-schoolers and their experiences with numbers and shapes in daily lives and games at nursery schools with a comparison with the mathematics classes in the first grade of elementary school. We also aim to provide insights for nursery schools on how to arouse childrenfs interest and support them to get familiar with geometry and numbers through games.
Our finding reveals that children naturally become familiar with geometry and numbers in their daily lives and their experiences become the foundation when they cope with elementary school mathematics. We also come to know that nursery teachers have to visualize the connection between their games with elementary school mathematics and actively arouse childrenfs interests and understanding. kn-abstract=@–{Œ¤‹†‚Å‚ÍA—cŽ™Šú‚ÌI‚í‚è‚܂łɈç‚Á‚Ä—~‚µ‚¢10‚ÌŽp‚̂ЂƂ‚ł ‚éAu”—ÊE}Œ`A•¶Žš“™‚Ö‚ÌŠÖSEŠ´Šov‚É’…–Ú‚µAAŠw‘O‚Ì‚TÎŽ™‚ÉÅ“_‚ð“–‚ÄA•ÛˆçŠ‚Ì“úí¶Šˆ‚â—V‚Ñ‚É‚¨‚¢‚ÄŽq‚Ç‚à‚ª‚ǂ̂悤‚È”—ÊE}Œ`‚ÉŠÖ‚·‚鎖•¿‚ðŒoŒ±‚µ‚Ä‚¢‚é‚Ì‚©A‚Ü‚½A‚»‚ÌŒoŒ±‚ð¬ŠwZ‚P”N¶‚ÌŽZ”‰È‚ÌŠwK“à—e‚ÆƂ炵‚ÄŒŸ“¢‚µ‚½B‚³‚ç‚ÉAŽq‚Ç‚à‚ª‰€¶Šˆ‚â—V‚Ñ‚Ì’†‚Å”—ÊE}Œ`‚ÉŠÖS‚ð‚à‚Á‚Äe‚µ‚ÝAŠw‚т𓾂邱‚Æ‚ðŽx‚¦‚é•Ûˆç‚ÌÝ‚è•û‚ɂ‚¢‚ÄŒŸ“¢‚µ‚½B
@‚»‚ÌŒ‹‰ÊAŽq‚Ç‚à‚Í“úí‚Ì’†‚ÅŽå‘Ì“I‚É”—ÊE}Œ`‚Ée‚µ‚ÞŒoŒ±‚ð‚·‚é‚Æ‹¤‚ÉA‚»‚ÌŒoŒ±‚ª¬ŠwZŽZ”‰È‚Ì“à—e‚ɘA‘±‚·‚éŠw‚Ñ‚ÌŠî‘b‚Æ‚È‚Á‚Ä‚¢‚邱‚Æ‚ª–¾‚ç‚©‚É‚È‚Á‚½B‚Ü‚½A•ÛˆçŽmŽ©g‚ª¬ŠwZŽZ”‚Æ‚ÌŒq‚ª‚è‚ðŒ©’Ê‚µ‚È‚ª‚çAŠá‘O‚ÌŽq‚Ç‚à‚Ì‹»–¡‚âŠÖS‚ɉˆ‚Á‚ĉ‡•‚·‚邱‚Æ‚ªê–å“I—Í—Ê‚Æ‚µ‚Ä‹‚ß‚ç‚ê‚邱‚Æ‚ªŽ¦´‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=SUZUKIFuka en-aut-sei=SUZUKI en-aut-mei=Fuka kn-aut-name=—é–Ø•–‰Ô kn-aut-sei=—é–Ø kn-aut-mei=•–‰Ô aut-affil-num=1 ORCID= en-aut-name=KATAYAMAMika en-aut-sei=KATAYAMA en-aut-mei=Mika kn-aut-name=•ÐŽR”ü kn-aut-sei=•ÐŽR kn-aut-mei=”ü aut-affil-num=2 ORCID= affil-num=1 en-affil=Mitsu Kanagawa Certified childcare center kn-affil=‰ªŽRŽsŒä’Ëàì”F’肱‚Ç‚à‰€ affil-num=2 en-affil=Graduate School of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ —cŽ™‹³ˆçuÀ en-keyword=10 ‚ÌŽp kn-keyword=10 ‚ÌŽp en-keyword=”—ÊE}Œ` kn-keyword=”—ÊE}Œ` en-keyword=•ÛˆçŽm kn-keyword=•ÛˆçŽm en-keyword=ê–å“I—Í—Ê kn-keyword=ê–å“I—Í—Ê en-keyword=¬ŠwZŽZ”‰È kn-keyword=¬ŠwZŽZ”‰È en-keyword=the Ideal Image by the End of Childhood kn-keyword=the Ideal Image by the End of Childhood en-keyword=numbers & geometry kn-keyword=numbers & geometry en-keyword=professional nursery school teachers kn-keyword=professional nursery school teachers en-keyword=elementary school kn-keyword=elementary school en-keyword=mathematics kn-keyword=mathematics END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=33 end-page=44 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Systematic Improvement of Lessons in Elementary Schools ?A Case Study of Japanese Language Instruction Aimed at Realizing the gIdeal Child Imageh? kn-title=¬ŠwZ‚É‚¨‚¯‚é‘gD“I‚ÈŽö‹Æ‰ü‘P‚Ì‚ ‚è•û@?u–ÚŽw‚·Žq‚Ç‚à‘œvŽÀŒ»‚ÉŒü‚¯‚½‘Œê‰ÈŽw“±‚ðŽ–—á‚Æ‚µ‚Ä? en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–{Œ¤‹†‚Ì–Ú“I‚ÍAu–ÚŽw‚·Žq‚Ç‚à‘œvŽÀŒ»‚ÉŒü‚¯‚½‘Œê‰È‚ÌŽö‹Æ‚­‚è‚Ì‹ï‘Ì‚ðŒŸ“¢‚µA¬ŠwZ‚É‚¨‚¯‚é‘gD“I‚ÈŽö‹Æ‰ü‘P‚Ì‚ ‚è•û‚ð’ñŒ¾‚·‚邱‚Æ‚É‚ ‚éB‹ï‘Ì“I‚É‚ÍAu–ÚŽw‚·Žq‚Ç‚à‘œvŽÀŒ»‚ÉŒü‚¯‚½‘Œê‰È‚ÌŽö‹Æ‚­‚è‚ð’Ê‚µ‚ÄA¡‚̎Љ¬ŠwZ‹³ˆç‚É‹‚ß‚é“ÁF‚ ‚éŽö‹Æ‚­‚è‚Ìi‚ß•û‚𖾂炩‚É‚·‚邽‚ßA‹Î–±Z‚Å‚ ‚é‘“‡’¬—§‘“‡¬ŠwZ‚ÉŠ‘®‚·‚鋳Žt‚ÌŽö‹Æ‚­‚è‚ð‘ÎÛ‚ÉŽ–—ጤ‹†‚ð“WŠJ‚µ‚½BŒŸ“¢‚ð’Ê‚¶‚Ä–¾‚ç‚©‚É‚È‚Á‚½‚±‚Æ‚ÍAŽö‹Æ‚­‚è‚É‚¨‚¯‚鋳Žt‚ÌŽvlEŽÀ‘H‰ß’ö‚ÆA‚±‚ê‚ç‚ðŽÀ‘HŽÒ‚ª”½È“I‚É‘¨‚¦’¼‚·‚½‚ß‚Ìu–ÚŽw‚·Žq‚Ç‚à‘œv‚É‚æ‚錾ŒêŠˆ“®‹ï‘̉»‚ÌŽè—§‚Ä‚Å‚ ‚éB‚³‚ç‚ÉAŽö‹Æ‚­‚è‚Ì‘gDEŒn“«‚ÍA‘¼Šw”N‹³Žt‚Ì–ðŠ„‚É‚æ‚Á‚Ä‚à‚½‚炳‚ê‚邱‚Æ‚ªŠm”F‚³‚ꂽ‚±‚Æ‚©‚çA‚»‚ê‚ç‚𓥂܂¦‚‚ÂAu–ÚŽw‚·Žq‚Ç‚à‘œvŽÀŒ»‚ÉŒü‚¯‚½Žö‹Æ‚­‚è‚Ì‚ ‚è•û‚ð‘ÌŒn‰»‚µ‚½B‚»‚¤‚·‚邱‚Æ‚ÅA¬ŠwZ‚É‚¨‚¯‚é‘gD“I‚ÈŽö‹Æ‰ü‘P‚ði‚ß‚Ä‚¢‚­‚½‚߂̉”\«‚ªŒ©o‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=KOMOTOAkihiro en-aut-sei=KOMOTO en-aut-mei=Akihiro kn-aut-name=‰Í–{ÍG kn-aut-sei=‰Í–{ kn-aut-mei=ÍG aut-affil-num=1 ORCID= en-aut-name=MIYAMOTOKoji en-aut-sei=MIYAMOTO en-aut-mei=Koji kn-aut-name=‹{–{_Ž¡ kn-aut-sei=‹{–{ kn-aut-mei=_Ž¡ aut-affil-num=2 ORCID= en-aut-name=IKEDAMasafumi en-aut-sei=IKEDA en-aut-mei=Masafumi kn-aut-name=’r“c‹§Žj kn-aut-sei=’r“c kn-aut-mei=‹§Žj aut-affil-num=3 ORCID= en-aut-name=MATUDASatoshi en-aut-sei=MATUDA en-aut-mei=Satoshi kn-aut-name=¼“c‘ kn-aut-sei=¼“c kn-aut-mei=‘ aut-affil-num=4 ORCID= affil-num=1 en-affil=Hayashima Elementary School (Graduate School of Education (Professional Degree Corse), Okayama University) kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@¶ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=4 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=–ÚŽw‚·Žq‚Ç‚à‘œ (The school's educational goals) kn-keyword=–ÚŽw‚·Žq‚Ç‚à‘œ (The school's educational goals) en-keyword=‰¿’l–Ú•W (into value-objectives) kn-keyword=‰¿’l–Ú•W (into value-objectives) en-keyword=‘ŒêŠw—Í (Japanese language ability) kn-keyword=‘ŒêŠw—Í (Japanese language ability) en-keyword=ƒJƒŠƒLƒ…ƒ‰ƒ€ƒ}ƒlƒWƒƒ“ƒg (Curriculum Management) kn-keyword=ƒJƒŠƒLƒ…ƒ‰ƒ€ƒ}ƒlƒWƒƒ“ƒg (Curriculum Management) en-keyword=‘gDEŒn“« (Organization and Systematic) kn-keyword=‘gDEŒn“« (Organization and Systematic) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=17 end-page=31 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Research of the Image of Teacher-Training Courses among Student Teachers in Non-Faculty of Education kn-title=‘SŠw‹³E‰Û’ö—šCŠw¶‚Ì‹³E‰Û’öƒCƒ[ƒW‚ÉŠÖ‚·‚錤‹† en-subtitle= kn-subtitle= en-abstract=The purpose of this study was to explore the image of teacher-training courses among student teachers in non-faculty of education. In this study, special attention to was paid to the difference first-year students and fourth-year students. This study 1 included student teachers in non-faculty of education. They were asked to answer metaphor-making task : gteacher-training coursesh. Major findings (study 1) were as follows: (a) analysis of metaphors and reasons regarding the image of teacher-training course revealed 19 categories. (b) The category with the most number of descriptions was gA place to learn to become a teacherh followed by gA place to grow as a personh. (c) There were differences in the number of descriptions in some categories between first-year students and fourth-year students. Next, major findings (study 2) were as follows: (a) Exploratory factor analysis of the concept of image of teacher-training courses revealed 11 factors such as gplace for active learningh and ghardh. (b) First-year students and fourth-year students had different scores on three factors: gOpportunity to reflect on the educational experienceh, gGreat valueh and gA place for longterm leaningh. These studies indicated that student teachers in non-faculty of education had various images teacher-training courses, and that there were differences in some images teacher-training course between first-year students and fourth-year students. kn-abstract=@–{Œ¤‹†‚Ì–Ú“I‚ÍC‘SŠw‹³E‰Û’ö—šCŠw¶‚Ì‹³E‰Û’öƒCƒ[ƒW‚ðŒŸ“¢‚·‚邱‚Æ‚Å‚ ‚Á‚½BŒ¤‹†‚P‚ł̓ƒ^ƒtƒ@[–@‚ð—p‚¢‚Ä‘SŠw‹³E‰Û’ö—šCŠw¶‚ð‘ÎÛ‚É‹³E‰Û’öƒCƒ[ƒW‚𒲸‚µC19‚̃JƒeƒSƒŠ[‚ª“¾‚ç‚ꂽBÅ‚à‹Lq‚ª‘½‚¢ƒJƒeƒSƒŠ[‚Íu‹³Žt‚ɂȂ邽‚ß‚ÌŠw‚Ñ‚Ìêv‚Å‚ ‚èCŽŸ‚¢‚Åul‚Æ‚µ‚Ă̬’·‚Ìêv‚Å‚ ‚Á‚½B‚Ü‚½C1”N¶‚Æ4”N¶‚Å‚¢‚­‚‚©‚̃JƒeƒSƒŠ[‚Å—LˆÓ·‚ªŒ©‚ç‚ꂽBŒ¤‹†‚Q‚Å‚ÍCŒ¤‹†‚P‚ðŠî‚É‹³E‰Û’öƒCƒ[ƒW‚𑪒肷‚éŽÚ“xì¬‚ðŽŽ‚Ý‚é‚Æ‹¤‚ÉC1”N¶‚Æ4”N¶‚Å‚Ì”äŠr‚ðs‚Á‚½B’²¸‚ÌŒ‹‰ÊC‹³E‰Û’öƒCƒ[ƒW‚Íu”\“®“I‚ÈŠw‚Ñ‚Ìêvu‘å•Ï‚³v‚È‚Ç‘S11ˆöŽq‚©‚ç‚Ȃ邱‚ÆCu”틳ˆç‘ÌŒ±‚ÌU‚è•Ô‚è‚Ì‹@‰ïvu‚¨“¾Š´vu’·Šú“I‚ÈŠw‚Ñ‚Ìêv‚É‚¨‚¢‚Ä1”N¶‚Æ4”N¶‚Å—LˆÓ·‚ª‚ ‚邱‚ÆC‚ªŽ¦´‚³‚ꂽB–{Œ¤‹†‚©‚ç‘SŠw‹³E‰Û’ö—šCŠw¶‚Ì‹³E‰Û’öƒCƒ[ƒW‚̈ê’[‚ª–¾‚ç‚©‚É‚³‚ê‚é‚Æ‹¤‚ÉC1”N¶‚Æ4”N¶‚Å—L‚µ‚Ä‚¢‚éƒCƒ[ƒW‚ª•”•ª“I‚ɈقȂé‰Â”\«‚ªŽ¦´‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=MISHIMATomotaka en-aut-sei=MISHIMA en-aut-mei=Tomotaka kn-aut-name=ŽO“‡’m„ kn-aut-sei=ŽO“‡ kn-aut-mei=’m„ aut-affil-num=1 ORCID= affil-num=1 en-affil=Center for Teacher Education and Development, Okayama University kn-affil=‰ªŽR‘åŠw‹³Žt‹³ˆçŠJ”­ƒZƒ“ƒ^[ en-keyword=‘SŠw‹³E‰Û’ö—šCŠw¶ (student teachers in non-faculty of education) kn-keyword=‘SŠw‹³E‰Û’ö—šCŠw¶ (student teachers in non-faculty of education) en-keyword=‹³E‰Û’öƒCƒ[ƒW (image of teacher-training courses) kn-keyword=‹³E‰Û’öƒCƒ[ƒW (image of teacher-training courses) en-keyword=ƒƒ^ƒtƒ@[ (metaphor) kn-keyword=ƒƒ^ƒtƒ@[ (metaphor) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=1 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Treatment of Learning about Marriage in High School Home Economics (2): Description Analysis of the Textbooks kn-title=‚“™ŠwZ‰Æ’ë‰È‚É‚¨‚¯‚錋¥‚ÉŠÖ‚·‚éŠwK‚̈µ‚¢i2j@‹³‰È‘‚Ì‹Lq•ªÍ‚ÉŠî‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–{e‚Å‚ÍCu‘½—l‰»‚·‚錋¥v‚Æ‚¢‚¤“ú–{‚ÌŒ»ó‚𓥂܂¦CŒ‹¥‚ÉŠÖ˜A‚·‚éŠwK“à—e‚ªC‚“™ŠwZ‰Æ’ë‰È‚É‚¨‚¢‚Ăǂ̂悤‚Ɉµ‚í‚ê‚Ä‚¢‚é‚©‚ð•ªÍ‚·‚邱‚Æ‚ð–Ú“I‚Æ‚µC•½¬30”N”Å‚Ìw‚“™ŠwZŠwKŽw“±—v—Ìx‚ÉŠî‚¢‚Ä\¬‚³‚ꂽu‰Æ’ëŠî‘bv‚Ì‹³‰È‘10û‚ð—p‚¢‚ÄŒ‹¥‚ÉŠÖ˜A‚·‚éŠwK“à—e‚ð•ªÍ‚µ‚½B•ªÍ‚ÌŒ‹‰ÊC‹³‰È‘‚É‚ÍCwŽw“±—v—Ìx‚ÉŠî‚¢‚ÄŒ‹¥“™‚ÉŠÖ˜A‚·‚é–@§“x‚Ì‹Lq‚ª‚Ý‚ç‚ê‚邱‚ÆCŒ‹¥‚ð‚ß‚®‚錻ó‚â•Ï‰»‚𔽉f‚µ‚½ŠwK“à—e‚ªŽæ‚舵‚í‚ê‚Ä‚¢‚邱‚Æ‚ðŠm”F‚µ‚½B‚Ü‚½C•v•w‚ÌŽC“¯«¥‚ðŽæ‚èã‚°C‹ï‘Ì“I‚ÈŠwKŠˆ“®‚ɂ‚¢‚Ä•ªÍ‚µ‚½Œ‹‰ÊC‹³‰È‘‚É‚æ‚Á‚Ä‚ÍC’mŽ¯‚⌻ó‚ð’ñŽ¦‚·‚éŠwK‚¾‚¯‚Å‚È‚­CŠwKŽÒ‚Å‚ ‚é‚Z¶‚ªŽ©‚çl‚¦‚邱‚ÆC‘I‘ð‚·‚é‚±‚ÆC‚³‚ç‚É‘¼l‚Ì‘I‘ð‚ɂ‚¢‚Ä‚à‹qŠÏ“I‚Él‚¦‚ç‚ê‚é‚悤‚É–â‚¢‚©‚¯‚Ä‚¢‚鋳‰È‘‚à‚Ý‚ç‚ꂽBŒ‹¥‚ÉŠÖ˜A‚·‚é–@—¥CŒê‹å‚ÌŒfÚ‚Ì—L–³CŠwKŠˆ“®‚É‚¨‚¢‚ÄC‹³‰È‘‚É‚æ‚Á‚Ď戵‚¢‚Ì·‚ª‚ ‚邱‚Æ‚ª–¾‚ç‚©‚É‚È‚Á‚½B en-copyright= kn-copyright= en-aut-name=TANABEShiho en-aut-sei=TANABE en-aut-mei=Shiho kn-aut-name=“c糎•à kn-aut-sei=“cç³ kn-aut-mei=Ž•à aut-affil-num=1 ORCID= en-aut-name=LEEKyoungwon en-aut-sei=LEE en-aut-mei=Kyoungwon kn-aut-name=—›ûm•Q kn-aut-sei=—› kn-aut-mei=ûm•Q aut-affil-num=2 ORCID= affil-num=1 en-affil=Fukuyama University kn-affil=•ŸŽR‘åŠw affil-num=2 en-affil=Faculty of EducationCOkayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=‚“™ŠwZ‰Æ’ë‰È (High School Home Economics) kn-keyword=‚“™ŠwZ‰Æ’ë‰È (High School Home Economics) en-keyword=‹³‰È‘ (Textbooks) kn-keyword=‹³‰È‘ (Textbooks) en-keyword=Œ‹¥ (Marriage) kn-keyword=Œ‹¥ (Marriage) en-keyword=‘½—l‰»‚·‚錋¥ kn-keyword=‘½—l‰»‚·‚錋¥ en-keyword=Course of Study kn-keyword=Course of Study END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž†E–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰ªŽR‘åŠw‹³Žt‹³ˆçŠJ”­ƒZƒ“ƒ^[‹I—v ‘æ15† ‘S•¶iˆêŠ‡ƒ_ƒEƒ“ƒ[ƒh—pj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue=1 article-no= start-page=2480231 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Specific enhancement of the translation of thermospermine-responsive uORF-containing mRNAs by ribosomal mutations in Arabidopsis thaliana en-subtitle= kn-subtitle= en-abstract= kn-abstract=Auxin-induced xylem formation in angiosperms is negatively regulated by thermospermine, whose biosynthesis is also induced by auxin. In Arabidopsis thaliana, loss-of-function mutants of ACL5, which encodes thermospermine synthase, exhibit a dwarf phenotype accompanied by excessive xylem formation. Studies of suppressor mutants that recover from the acl5 dwarf phenotype suggest that thermospermine alleviates the inhibitory effect of an upstream open-reading frame (uORF) on the main ORF translation of SAC51 mRNA. Many suppressor mutations for acl5 have been mapped to the uORF conserved in the SAC51 family or to ribosomal protein genes, such as RPL10A, RPL4A, and RACK1A. In this study, we identified newly isolated acl5 suppressors, sac501, sac504, and sac506, which are additional alleles of RPL10A and the uORFs of SAC51 family members, SACL1 and SACL3, respectively. To investigate whether acl5-suppressor alleles of ribosomal genes broadly affect translation of uORF-containing mRNAs, we examined GUS activity in several 5'-GUS fusion constructs. Our results showed that these alleles enhanced GUS activity in SAC51 and SACL3 5'-fusion constructs but had no effect on other 5'-fusion constructs unrelated to thermospermine response. This suggests that these ribosomal proteins are specifically involved in the thermospermine-mediated regulation of mRNA translation. en-copyright= kn-copyright= en-aut-name=MutsudaKoki en-aut-sei=Mutsuda en-aut-mei=Koki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NishiiYuichi en-aut-sei=Nishii en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ToyoshimaTomohiko en-aut-sei=Toyoshima en-aut-mei=Tomohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=FukushimaHiroko en-aut-sei=Fukushima en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MotoseHiroyasu en-aut-sei=Motose en-aut-mei=Hiroyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakahashiTaku en-aut-sei=Takahashi en-aut-mei=Taku kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=mRNA translation kn-keyword=mRNA translation en-keyword=RPL10 kn-keyword=RPL10 en-keyword=suppressor mutant kn-keyword=suppressor mutant en-keyword=thermospermine kn-keyword=thermospermine en-keyword=uORF kn-keyword=uORF END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Novel pulmonary abdominal normothermic regional perfusion circuit for simultaneous in-donor evaluation and preservation of lungs and abdominal organs in donation after circulatory death en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective To overcome limitations of traditional ex vivo lung perfusion (EVLP) for controlled donation after circulatory death (cDCD) lungs, this study aimed to evaluate a novel pulmonary abdominal normothermic regional perfusion (PANRP) technique, which we uniquely designed, for in situ assessment of lungs from cDCD donors.
Methods We modified the abdominal normothermic regional perfusion circuit for simultaneous lung and abdominal organ assessment using independent extracorporeal membrane oxygenation components. Blood was oxygenated via a membrane oxygenator and returned to the body, with pulmonary flow adjusted to maintain pressure? Results PANRP maintained stable lung function, with P/F ratios above 300, and preserved abdominal organ parameters, including stable AST, ALT, BUN, and Cr levels. Adequate urine output was observed, indicating normal renal function. Pulmonary artery pressure remained? Conclusions PANRP offers a promising alternative to traditional EVLP for cDCD lung evaluation, allowing in situ assessment of multiple organs simultaneously. This approach may overcome logistical and economic challenges associated with ex vivo techniques, enabling a more efficient evaluation process. Further studies are warranted to confirm its clinical applicability and impact on long-term outcomes. en-copyright= kn-copyright= en-aut-name=TanakaShin en-aut-sei=Tanaka en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UmedaMasashi en-aut-sei=Umeda en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UjikeHiroyuki en-aut-sei=Ujike en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=RyukoTsuyoshi en-aut-sei=Ryuko en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TomiokaYasuaki en-aut-sei=Tomioka en-aut-mei=Yasuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyoshiKentaroh en-aut-sei=Miyoshi en-aut-mei=Kentaroh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkazakiMikio en-aut-sei=Okazaki en-aut-mei=Mikio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SugimotoSeiichiro en-aut-sei=Sugimoto en-aut-mei=Seiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of General Thoracic and Breast and Endocrinological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=2 en-affil=Department of General Thoracic and Breast and Endocrinological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=3 en-affil=Department of General Thoracic Surgery, Shimane University Graduate School of Medicine kn-affil= affil-num=4 en-affil=Department of General Thoracic and Breast and Endocrinological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=5 en-affil=Department of General Thoracic and Breast and Endocrinological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=6 en-affil=Department of General Thoracic and Breast and Endocrinological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=7 en-affil=Department of General Thoracic and Breast and Endocrinological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=8 en-affil=Department of General Thoracic and Breast and Endocrinological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=9 en-affil=Department of General Thoracic and Breast and Endocrinological Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= en-keyword=Lung preservation kn-keyword=Lung preservation en-keyword=Donation after circulatory death kn-keyword=Donation after circulatory death en-keyword=Abdominal normothermic regional perfusion kn-keyword=Abdominal normothermic regional perfusion END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰œ•t en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page=193 end-page=193 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ƒZƒ“ƒ^[•ñ“Še—v—Ì en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page=185 end-page=192 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Ž‘—¿ : 2020`2022”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page=33 end-page=184 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰^‰c : 2020`2022”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page=29 end-page=31 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=’nˆæ˜AŒg : 2020`2022”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page=15 end-page=28 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ŽŽŒ±Œ¤‹† : 2020`2022”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page=1 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‹³ˆç : 2020`2022”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=1 article-no= start-page=1757 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250224 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Keratinocyte-driven dermal collagen formation in the axolotl skin en-subtitle= kn-subtitle= en-abstract= kn-abstract=Type I collagen is a major component of the dermis and is formed by dermal fibroblasts. The development of dermal collagen structures has not been fully elucidated despite the major presence and importance of the dermis. This lack of understanding is due in part to the opacity of mammalian skin and it has been an obstacle to cosmetic and medical developments. We reveal the process of dermal collagen formation using the highly transparent skin of the axolotl and fluorescent collagen probes. We clarify that epidermal cells, not dermal fibroblasts, contribute to dermal collagen formation. Mesenchymal cells (fibroblasts) play a role in modifying the collagen fibers already built by keratinocytes. We confirm that collagen production by keratinocytes is a widely conserved mechanism in other model organisms. Our findings warrant a change in the current consensus about dermal collagen formation and could lead to innovations in cosmetology and skin medication. en-copyright= kn-copyright= en-aut-name=OhashiAyaka en-aut-sei=Ohashi en-aut-mei=Ayaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakamotoHirotaka en-aut-sei=Sakamoto en-aut-mei=Hirotaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KurodaJunpei en-aut-sei=Kuroda en-aut-mei=Junpei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KondoYohei en-aut-sei=Kondo en-aut-mei=Yohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KameiYasuhiro en-aut-sei=Kamei en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NonakaShigenori en-aut-sei=Nonaka en-aut-mei=Shigenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=FurukawaSaya en-aut-sei=Furukawa en-aut-mei=Saya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamamotoSakiya en-aut-sei=Yamamoto en-aut-mei=Sakiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SatohAkira en-aut-sei=Satoh en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Graduate School of Environment, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environment, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Frontier Biosciences, Osaka University kn-affil= affil-num=4 en-affil=Center for One Medicine Innovative Translational Research (COMIT), Nagoya University kn-affil= affil-num=5 en-affil=Laboratory for Biothermology, National Institute for Basic Biology kn-affil= affil-num=6 en-affil=The Graduate University for Advanced Studies (SOKENDAI) kn-affil= affil-num=7 en-affil=Graduate School of Environment, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=8 en-affil=Graduate School of Environment, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=9 en-affil=Graduate School of Environment, Life, Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=7506 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250303 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A glucocorticoid-regulating molecule, Fkbp5, may interact with mitogen-activated protein kinase signaling in the organ of Corti of mice cochleae en-subtitle= kn-subtitle= en-abstract= kn-abstract=FKBP5 is a 51-Da FK506-binding protein and member of the immunophilin family involved in controlling the signaling of glucocorticoid receptor from the cytosol to nucleus. Fkbp5 has previously been shown to be expressed in murine cochlear tissue, including the organ of Corti (i.e., the sensory epithelium of the cochlea). Fkbp5-/- mice as used in this study show hearing loss in the low-frequency (8-kHz) range and click-evoked auditory brainstem response (ABR) threshold compared to wild-type mice. Both Fkbp5-/- and wild-type mice showed hearing loss at all frequencies and click-ABR thresholds at 24 h and 14 days following acoustic overexposure (AO). Tissues of the organ of Corti were subjected to RNA sequencing and KEGG pathway analysis. In Fkbp5-/- mice before AO, the mitogen-activated protein kinase (MAPK) signaling pathway was dysregulated compared to wild-type mice. In wild-type mice at 12 h following AO, the most significantly modulated KEGG pathway was the TNF signaling pathway and major MAPK molecules p38 and Jun were involved in the TNF signaling pathway. In Fkbp5-/- mice at 12 h following AO, the MAPK signaling pathway was dysregulated compared to wild-type mice following AO. In conclusion, Fkbp5 interacts with MAPK signaling in the organ of Corti in mice cochleae. en-copyright= kn-copyright= en-aut-name=SatoAsuka en-aut-sei=Sato en-aut-mei=Asuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OmichiRyotaro en-aut-sei=Omichi en-aut-mei=Ryotaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MaedaYukihide en-aut-sei=Maeda en-aut-mei=Yukihide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AndoMizuo en-aut-sei=Ando en-aut-mei=Mizuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=The organ of Corti kn-keyword=The organ of Corti en-keyword=Acoustic trauma kn-keyword=Acoustic trauma en-keyword=RNA sequencing kn-keyword=RNA sequencing en-keyword=51-Da FK506-binding protein kn-keyword=51-Da FK506-binding protein en-keyword=Mitogen-activated protein kinase signaling kn-keyword=Mitogen-activated protein kinase signaling en-keyword=Tumor necrosis factor signaling kn-keyword=Tumor necrosis factor signaling END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page=iv end-page=v dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page=i end-page=iii dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=˜ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ꎓ¡–Ms kn-aut-sei=ꎓ¡ kn-aut-mei=–Ms aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw”_Šw•”•‘®ŽR—zŒ—ƒtƒB[ƒ‹ƒh‰ÈŠwƒZƒ“ƒ^[ END start-ver=1.4 cd-journal=joma no-vol=43-45 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž† en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=752 cd-vols= no-issue= article-no= start-page=151481 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Discovery of myeloid zinc finger (MZF) 1 nuclear bodies en-subtitle= kn-subtitle= en-abstract= kn-abstract=Myeloid zinc finger 1 (MZF1) is a multifaceted transcription factor that can act either as a transcriptional activator or a gene repressor. We examined its production of nuclear bodies (NBs) and subcellular localization. Proteomic and protein?protein interaction analysis were used to identify its cofactors and interactions. These revealed the presence of MZF1-NBs (intranuclear oligomers containing MZF1). MZF-NBs are similar to some other nuclear bodies, notably promyelocytic leukemia (PML) -NBs in terms of size and morphology. However the two structures appear to be different. MZF-NBs and PML-NBs were found to associate in the nucleus. Both MZF1 and PML are SUMO1-SUMOylated in PC-3 cells. Sumoylated MZF1 can interact with proteins containing SUMO-interaction motifs (SIM) through SUMO-SIM interaction. Interactome analysis revealed that its NBs participate in the stress response (TPR and UBAP2L), protein folding (CALR and ANKRD40), transcription, post-translational modification (TRIM33, ACOT7, CAMK2D, and CAMK2G), and RNA binding (ALURBP and CPSF5). en-copyright= kn-copyright= en-aut-name=EguchiTakanori en-aut-sei=Eguchi en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=CalderwoodStuart K. en-aut-sei=Calderwood en-aut-mei=Stuart K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Division of Molecular and Cellular Biology, Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School kn-affil= en-keyword=Myeloid zinc finger 1 kn-keyword=Myeloid zinc finger 1 en-keyword=MZF1 kn-keyword=MZF1 en-keyword=Nuclear body kn-keyword=Nuclear body en-keyword=PML kn-keyword=PML en-keyword=Sumoylation kn-keyword=Sumoylation en-keyword=SCAN domain protein kn-keyword=SCAN domain protein END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=1 end-page=60 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Annual report / Institute of Plant Science and Resources, Okayama University kn-title=‰ªŽR‘åŠwŽ‘Œ¹A•¨‰ÈŠwŒ¤‹†Š•ñ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute of Plant Science and Resources, Okayama University en-aut-sei=Institute of Plant Science and Resources, Okayama University en-aut-mei= kn-aut-name=‰ªŽR‘åŠwŽ‘Œ¹A•¨‰ÈŠwŒ¤‹†Š kn-aut-sei=‰ªŽR‘åŠwŽ‘Œ¹A•¨‰ÈŠwŒ¤‹†Š kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=— •\Ž†E‰p•¶–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰œ•t en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=81 end-page=94 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Building a Task Bank to Enhance Task-Supported Language Teaching : Tailoring Task Difficulty to Match Proficiency Levels of Japanese Language Learners kn-title=ƒ^ƒXƒNŽx‰‡Œ^Žw“±‚ðŽx‰‡‚·‚éƒ^ƒXƒNEƒoƒ“ƒN‚Ì\’z‚ð–ÚŽw‚µ‚Ä\“ú–{ŒêŠwKŽÒ‚ÌKn“x‚ɇ‚킹‚½ƒ^ƒXƒN‚Ì“ïˆÕ“x’²®\ en-subtitle= kn-subtitle= en-abstract=This paper reports on the creation and practice of using tasks for task-supported language teaching (TSLT). While focusing on TSLT, in which tasks are incorporated into the existing curriculum as a supplement, the aim is to construct a task bank to support the transition from PPP (Presentation-Practice-Production) classes to TSLT. The results of the analysis on the changes in utterances during tasks with different levels of difficulty showed that (1) the number of utterances did not increase in proportion to the number of items (elements or information) included in the task, (2) tasks with more items and higher difficulty increased the range of expressions used by Japanese learners, and (3) the goal of the task presented in the role card made it possible to predict the intention of the utterance, leading to a tendency to tolerate inaccurate utterances. kn-abstract=–{e‚Å‚ÍCƒ^ƒXƒNŽx‰‡Œ^Žw“±iTSLTj—p‚̃^ƒXƒN‚Ì쬂¨‚æ‚у^ƒXƒN‚ð—p‚¢‚½ŽÀ‘H‚ɂ‚¢‚Ä•ñ‚·‚éBŠù‘¶‚̃JƒŠƒLƒ…ƒ‰ƒ€‚Ì’†‚Ƀ^ƒXƒN‚ð•â•“I‚ÉŽæ‚è“ü‚ê‚éTSLT‚É’…–Ú‚µCPPPiPresentation-Practice-ProductionjŽö‹Æ‚©‚çTSLT‚ւ̈Ús‚ðŽx‰‡‚·‚éƒ^ƒXƒNEƒoƒ“ƒN‚Ì\’z‚ð–ÚŽw‚µC‰‹‰“ú–{Œê‹³‰È‘‚̃GƒNƒTƒTƒCƒY‚ðƒx[ƒX‚ÉC“¯‚¶ƒgƒsƒbƒN‚Å“ïˆÕ“x‚̈قȂéƒ^ƒXƒN‚Ì쬂ðs‚Á‚½B“ïˆÕ“x‚̈Ⴂ‚É‚æ‚éƒ^ƒXƒN’†‚Ì”­˜b‚̕ω»‚ð•ªÍ‚µ‚½Œ‹‰ÊCi1j”­˜b”‚ɂ‚¢‚Ă̓^ƒXƒN‚ÉŠÜ‚Ü‚ê‚逖ڔi—v‘f‚âî•ñ‚Ì”j‚Ì‘‰Á‚É”ä—Ⴕ‚Ä‘‚¦‚é‚킯‚Å‚Í‚È‚¢‚±‚ÆCi2j€–Ú”‚ª‘½‚¢“ïˆÕ“x‚ª‚‚¢ƒ^ƒXƒN‚Å‚ÍC“ú–{ŒêŠwKŽÒ‚Ì•\Œ»‚ÌŽg—p•‚ªL‚ª‚邱‚ÆCi3jƒ^ƒXƒN‚̃S[ƒ‹‚ªƒ[ƒ‹ƒJ[ƒh‚É‚Ä’ñŽ¦‚³‚ê‚Ä‚¢‚邱‚Æ‚É‚æ‚èC”­˜bˆÓ}‚Ì—\‘ª‚ª‰Â”\‚É‚È‚èC•s³Šm‚È”­˜b‚ª‹–—e‚³‚ê‚éŒXŒü‚ª‚ ‚邱‚Æ‚ªŽ¦‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=SUESHIGEMiwa en-aut-sei=SUESHIGE en-aut-mei=Miwa kn-aut-name=––”É”ü˜a kn-aut-sei=––”É kn-aut-mei=”ü˜a aut-affil-num=1 ORCID= affil-num=1 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ en-keyword=PPP kn-keyword=PPP en-keyword=TSLT kn-keyword=TSLT en-keyword=ƒ^ƒXƒN kn-keyword=ƒ^ƒXƒN en-keyword=€–Ú” kn-keyword=€–Ú” en-keyword=“ïˆÕ“x’²® kn-keyword=“ïˆÕ“x’²® END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=71 end-page=80 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=KIBITANGO : Development and Implementation of an Academic English Vocabulary Learning Program kn-title=‚«‚Ñ‚½‚ñ‚² \ƒAƒJƒfƒ~ƒbƒN‰p’PŒêŠwKƒvƒƒOƒ‰ƒ€‚ÌŠJ”­‚ÆŽÀ‘H•ñ\ en-subtitle= kn-subtitle= en-abstract=At Okayama University, we have developed and provided a self-study material called "Kibitango" to help students improve their academic English vocabulary. The project began in 2019, with a focus on collecting frequently used words from academic journals, resulting in a list of 1,500 words. Each word comes with explanations by project members and examples of how it is used in academic papers. The material has been available to students since the 2022 academic year. Registered students receive one word per day via email and learn through the Kibitango website. The number of users has steadily increased. Today, however, several challenges have emerged, including the need to update the word list and improve the delivery method and system. kn-abstract=‰ªŽR‘åŠw‚Å‚ÍŠwp‰pŒê‚ÌŒêœb—Í‚ðL‚΂·‚½‚ß‚ÌŽ©K‹³Þ‚Æ‚µ‚ÄAu‚«‚Ñ‚½‚ñ‚²v‚ðŠJ”­‚µŠw¶‚É’ñ‹Ÿ‚µ‚Ä‚¢‚éB2019”N‚©‚çŠJ”­‚Ì‚½‚߂̃vƒƒWƒFƒNƒg‚ðŠJŽn‚µAŠwpŽGŽ‚©‚ç•po’PŒê‚ðŽûW‚µ1500Œê‚̃ŠƒXƒg‚ð쬂µ‚½B’PŒê‚ɂ͈Ӗ¡E”­‰¹‚È‚Ç‚ÌŠî‘bî•ñˆÈŠO‚ÉAƒvƒƒWƒFƒNƒgƒƒ“ƒo[‚É‚æ‚é‰ðà‚âŽÀۂɂǂ̂悤‚ÉŠwp˜_•¶’†‚ÉŽg—p‚³‚ê‚Ä‚¢‚é‚©‚ÌŽÀ—á‚ð•t‚µ‚Ä‚¢‚éBŠw¶‚Ö‚Ì’ñ‹Ÿ‚Í2022”N“x‚©‚ç‚ÅA“o˜^‚µ‚½Šw¶‚Ƀ[ƒ‹‚ňê“úˆê’PŒê”zM‚µAê—pƒEƒFƒbƒuƒTƒCƒg‚ÅŠwK‚³‚¹‚é‚Æ‚¢‚¤ƒVƒXƒeƒ€‚Å‚ ‚éB—˜—pŽÒ‚à‡’²‚É‘‚¦‚Ä‚¢‚éBŠJ”­ŠJŽn‚©‚ç‚T”NA’ñ‹Ÿ‚©‚ç‚Q”NŒo‰ß‚µA’PŒêƒŠƒXƒg‚̃Aƒbƒvƒf[ƒg‚â’ñ‹Ÿ•û–@EƒVƒXƒeƒ€‚̉ü‘P‚Ȃljۑè‚à–¾‚ç‚©‚É‚È‚Á‚Ä‚¢‚éB en-copyright= kn-copyright= en-aut-name=IGARASHIMasumi en-aut-sei=IGARASHI en-aut-mei=Masumi kn-aut-name=ŒÜ\—’”ü kn-aut-sei=ŒÜ\—’ kn-aut-mei=”ü aut-affil-num=1 ORCID= en-aut-name=OGINOMasaru en-aut-sei=OGINO en-aut-mei=Masaru kn-aut-name=‰¬–ìŸ kn-aut-sei=‰¬–ì kn-aut-mei=Ÿ aut-affil-num=2 ORCID= en-aut-name=OTOSHIJunko en-aut-sei=OTOSHI en-aut-mei=Junko kn-aut-name=‘å”N‡Žq kn-aut-sei=‘å”N kn-aut-mei=‡Žq aut-affil-num=3 ORCID= en-aut-name=TERANISHIMasako en-aut-sei=TERANISHI en-aut-mei=Masako kn-aut-name=Ž›¼‰ëŽq kn-aut-sei=Ž›¼ kn-aut-mei=‰ëŽq aut-affil-num=4 ORCID= en-aut-name=YOSHIDAAzumi en-aut-sei=YOSHIDA en-aut-mei=Azumi kn-aut-name=‹g“cˆÀ“Ü kn-aut-sei=‹g“c kn-aut-mei=ˆÀ“Ü aut-affil-num=5 ORCID= en-aut-name=KENMOTSUYoshi en-aut-sei=KENMOTSU en-aut-mei=Yoshi kn-aut-name=™›Ži kn-aut-sei=™›Ž kn-aut-mei=i aut-affil-num=6 ORCID= affil-num=1 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ affil-num=2 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ affil-num=3 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ affil-num=4 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ affil-num=5 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ affil-num=6 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ en-keyword=ŠwpŒêœb kn-keyword=ŠwpŒêœb en-keyword=‰pŒêŒêœb—Í kn-keyword=‰pŒêŒêœb—Í en-keyword=Ž©K‹³Þ kn-keyword=Ž©K‹³Þ en-keyword=‹³ÞŠJ”­ kn-keyword=‹³ÞŠJ”­ END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=49 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Online Exchange Program between Sungkyunkwan University,Jilin University,and Okayama University : Practice Report kn-title=¬‹ÏŠÙE‹g—Ñ‘åŠwŒð—¬ƒvƒƒOƒ‰ƒ€yƒIƒ“ƒ‰ƒCƒ“zŽÀ‘H•ñ en-subtitle= kn-subtitle= en-abstract=The Institute for Promotion of Education and Campus Life at Okayama University hosted 5th annual Sungkyunkwan University (South Korea) and Jilin University (China) Exchange Program online. This program convened Sungkyunkwan University students, Jilin University students, and Okayama University students to engage in discussion, exploration, and presentation of cultural topics. While participants used Japanese as their common language, they addressed and overcame communication challenges that arise due to language barriers and cultural differences. The current report explores the programfs significance for global citizenship education, programfs results, several issues encountered during its implementation, and actions to resolve those issues. kn-abstract=‰ªŽR‘åŠw‹³ˆç„i‹@\‰CŠO‘ŒêŒn‚ª–ˆ”N‚QŒŽ‚ɃIƒ“ƒ‰ƒCƒ“‚ÅŽÀŽ{‚µ‚Ä‚¢‚éu¬‹ÏŠÙE‹g —Ñ‘åŠwŒð—¬ƒvƒƒOƒ‰ƒ€v‚ÍA“ú’†ŠØŽOƒ•‘‚Ì‘åŠw‚ÌŠw¶‚ªA“ú–{Œê‚ð‹¤’ÊŒ¾Œê‚Æ‚µ‚ÄA•¡ ”‚Ì•¶‰»EŒ¾ŒêAŠwKŒ¾Œê‚Æ•êŒê‚̈Ⴂ‚È‚Ç‚ð•ïÛ‚µ‚½ê‚Ŷ‚¶‚éƒRƒ~ƒ…ƒjƒP[ƒVƒ‡ƒ“ã ‚Ì–â‘è‚ð‰ðŒˆ‚µ‚È‚ª‚çA—lX‚Șb‘è‚̃fƒBƒXƒJƒbƒVƒ‡ƒ“‚âƒvƒŒƒ[ƒ“ƒe[ƒVƒ‡ƒ“‚ðs‚È‚¤B –{ŽÀ‘H•ñ‚ÍA‚±‚̃vƒƒOƒ‰ƒ€‚ÌŽïŽ|‚Ƭ‰ÊA‚Ü‚½ŽÀ‘H‚É“–‚½‚Á‚Ä‚Ì—lX‚ȉۑè‚Æ‚»‚ê‚É ‘΂·‚éŽæ‚è‘g‚݂ɂ‚¢‚Ä•ñ‚µAƒRƒƒiŒã‚̑ی𗬂̈ê‚‚̃‚ƒfƒ‹‚ƂȂ邱‚Æ‚ðŠú‘Ò‚· ‚é‚à‚Ì‚Å‚ ‚éB en-copyright= kn-copyright= en-aut-name=FUJIWARAYuko en-aut-sei=FUJIWARA en-aut-mei=Yuko kn-aut-name=“¡Œ´—SŽq kn-aut-sei=“¡Œ´ kn-aut-mei=—SŽq aut-affil-num=1 ORCID= en-aut-name=AKITASetsuko en-aut-sei=AKITA en-aut-mei=Setsuko kn-aut-name=H“cߎq kn-aut-sei=H“c kn-aut-mei=ߎq aut-affil-num=2 ORCID= en-aut-name=ISHIITomomi en-aut-sei=ISHII en-aut-mei=Tomomi kn-aut-name=Έä—F”ü kn-aut-sei=Έä kn-aut-mei=—F”ü aut-affil-num=3 ORCID= en-aut-name=SATOMiho en-aut-sei=SATO en-aut-mei=Miho kn-aut-name=²“¡”ü•ä kn-aut-sei=²“¡ kn-aut-mei=”ü•ä aut-affil-num=4 ORCID= affil-num=1 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ affil-num=2 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw”ñí‹ÎuŽt affil-num=3 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ affil-num=4 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw”ñí‹ÎuŽt en-keyword=ŽO‘ŠÔŒð—¬ kn-keyword=ŽO‘ŠÔŒð—¬ en-keyword=ˆÙ•¶‰»—‰ð kn-keyword=ˆÙ•¶‰»—‰ð en-keyword=•¡Œ¾ŒêE•¡•¶‰»Žå‹` kn-keyword=•¡Œ¾ŒêE•¡•¶‰»Žå‹` en-keyword=ƒCƒ“ƒNƒ‹[ƒWƒ‡ƒ“ kn-keyword=ƒCƒ“ƒNƒ‹[ƒWƒ‡ƒ“ en-keyword=ƒAƒNƒeƒBƒuƒ‰[ƒjƒ“ƒO kn-keyword=ƒAƒNƒeƒBƒuƒ‰[ƒjƒ“ƒO END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=33 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Old Stories, Original Retellings : The Heike-related Tales in the Repertory of the Blind Biwa Players of Kyushu en-subtitle= kn-subtitle= en-abstract= kn-abstract=While higobiwa, the blind biwa players' tradition of Kyushu, is regarded as a historically distinctive genre, its evolution has been influenced by interactions with other storytelling traditions. It is evident that higobiwa borrowed stories from other genres and adapted them to its own distinctive narrative style. The findings of this research focused on the Heike-related tales reveal significant similarities between the tales of Ichi-no-Tani and Ko-Atsumori in the blind biwa players' tradition and Ko-Atsumori in the kojoruri tradition. These parallels suggest a shared narrative lineage between these two performance genres, prompting a reevaluation of our understanding of the transmission and evolution of oral narratives within the blind biwa players' tradition of Kyushu and shedding light on the dynamic nature and the interconnectedness of different performance traditions within Japan. en-copyright= kn-copyright= en-aut-name=KHALMIRZAEVASaida en-aut-sei=KHALMIRZAEVA en-aut-mei=Saida kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Institute of Global Human Resource Development, Okayama University kn-affil= en-keyword=higobiwa kn-keyword=higobiwa en-keyword=the blind biwa players' tradition kn-keyword=the blind biwa players' tradition en-keyword=kojoruri kn-keyword=kojoruri en-keyword=Ichi-no-Tani kn-keyword=Ichi-no-Tani en-keyword=Ko-Atsumori kn-keyword=Ko-Atsumori END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=13 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Research on Factors Promoting Study in Japan : Cases of International Students from South-East Asia kn-title=“ú–{‚Ö‚Ì—¯Šw‚ð‘£i‚·‚é—vˆö‚ÉŠÖ‚·‚錤‹†@|“Œ“ìƒAƒWƒA‚©‚ç‚Ì—¯Šw¶‚ðŽ–—á‚Æ‚µ‚Ä| en-subtitle= kn-subtitle= en-abstract=In this study, international students from Southeast Asia were asked, 'Why did you decide to study in Japan?' and the information was collected through semi-structured interviews. The results showed that (i) international students' image of Japan, (ii) parents' image of Japan, (iii) the availability of scholarships, (iv) affordable tuition fees and living costs, and (v) the existence of a community of people from the country of origin., were found to be important. It was assumed that some of this information and image is formed by the international students' (1) satisfaction with their study destination, (2) opportunities to interact with Japanese people, (3) ease of living in Japan, (4) Japanese language level, (5) understanding of Japanese culture, etc., and is reinforced through word of mouth and the internet. Therefore, supporting the creation of these environments will create a positive image of studying in Japan and increase the number of students from Southeast Asia. kn-abstract=@–{Œ¤‹†‚Å‚ÍA“Œ“ìƒAƒWƒA‚©‚ç—¯Šw‚µ‚Ä‚¢‚é—¯Šw¶15l‚ð‘ÎÛ‚Æ‚µ‚Äu‚È‚º“ú–{‚É—¯Šw‚µ‚½‚Ì‚©HvA”¼\‘¢‰»ƒCƒ“ƒ^ƒrƒ…[‚É‚æ‚èî•ñ‚ðŽûW‚µ‚½B‚»‚ÌŒ‹‰ÊA(i) —¯Šw¶‚Ì“ú–{‚ɑ΂·‚éƒCƒ[ƒWA(ii) •ÛŒìŽÒ‚Ì“ú–{‚ɑ΂·‚éƒCƒ[ƒWA(iii) §Šw‹à‚Ì‹@‰ïA(iv) Ž„”ï—¯Šw‚ª‰Â”\‚ÈŠw”ïE¶Šˆ”ƒxƒ‹A(v) og‘ƒRƒ~ƒ…ƒjƒeƒB[‚Ì—L–³A‚ªd—v‚Å‚ ‚邱‚Æ‚ª•ª‚©‚Á‚½B‚±‚ê‚ç‚Ìî•ñ‚âƒCƒ[ƒW‚̈ꕔ‚ÍA(1) —¯Šwæ‚Å‚Ì–ž‘«“xA(2) “ú–{l‚Ƃ̌𗬋@‰ïA(3) ¶Šˆ‚Ì‚µ‚â‚·‚³A(4) —¯Šw¶‚Ì“ú–{ŒêƒŒƒxƒ‹A(5) “ú–{•¶‰»‚ɑ΂·‚闉𓙂ɂæ‚Á‚ÄŒ`¬‚³‚êAƒƒRƒ~‚âƒCƒ“ƒ^[ƒlƒbƒg‚ð’Ê‚¶‚Ä‹­‰»‚³‚ê‚邱‚Æ‚ª„‘ª‚³‚ꂽB‚æ‚Á‚ÄAã‹L‚Ì€–Ú‚É’…–Ú‚µA—¯Šw¶‚Ì–ž‘«“x“™‚ðŒüコ‚¹‚邽‚߂̊‹«‚­‚è‚ðŽx‰‡‚µ‚Ä‚¢‚­‚±‚Æ‚ªA“ú–{—¯Šw‚ɑ΂·‚éƒvƒ‰ƒX‚̃Cƒ[ƒW‚ðì‚èA“Œ“ìƒAƒWƒA‚©‚ç‚Ì—¯Šw¶‘‚ɂ‚Ȃª‚Á‚Ä‚¢‚­‚Æl‚¦‚ç‚ꂽB en-copyright= kn-copyright= en-aut-name=INAMORITakao en-aut-sei=INAMORI en-aut-mei=Takao kn-aut-name=ˆîXŠx‰› kn-aut-sei=ˆîX kn-aut-mei=Šx‰› aut-affil-num=1 ORCID= affil-num=1 en-affil=Institute of Global Human Resource Development, Okayama University kn-affil=‰ªŽR‘åŠwƒOƒ[ƒoƒ‹lވ笉@ en-keyword=“ú–{—¯Šw kn-keyword=“ú–{—¯Šw en-keyword=—¯Šw¶ kn-keyword=—¯Šw¶ en-keyword=“Œ“ìƒAƒWƒA kn-keyword=“Œ“ìƒAƒWƒA en-keyword=ASEAN kn-keyword=ASEAN en-keyword=‘£i—vˆö kn-keyword=‘£i—vˆö END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=1 end-page=12 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Relationship between Sexual Minorities and Attention Deficit Hyperactivity Disorder (ADHD) kn-title=ƒZƒNƒVƒ…ƒAƒ‹ƒ}ƒCƒmƒŠƒeƒB‚Æ”­’BáŠQ‚ÌADHD“Á«‚Æ‚ÌŠÖ˜A en-subtitle= kn-subtitle= en-abstract=To reveal the association between various sexual minority groups and the developmental disorder (ADHD), a web-based survey was conducted. Adults aged 18 years and over were surveyed and 11018 people (mean age 39.47 years) responded. The Adult ADHD Self-Rating Scale was used. For each sexual minority, a t-test was performed for ADHD scores and subscale scores of ginattention,h ghyperactivity,h and gimpulsivity,h and a x2 test was performed for the number of persons above the cut-off. All sexual minority groups had significantly higher ADHD and subscale scores and significantly more people above the cut-off scores, so the close association was evident. There was no significant difference in ADHD scores or numbers of persons between transwomen and transmen. kn-abstract=@—lX‚ȃZƒNƒVƒ…ƒAƒ‹ƒ}ƒCƒmƒŠƒeƒB‚Æ”­’BáŠQ‚ÌADHDiAttention Deficit Hyperactivity Disorderj‚Æ‚ÌŠÖ˜A‚𖾂炩‚É‚·‚邽‚ßC WEB’²¸‚ðs‚Á‚½B18ΈÈã‚̬l‚ð‘ÎÛ‚Æ‚µC11,018li•½‹Ï”N39.47Îj‚©‚ç‰ñ“š‚𓾂½BADHD‚𑪂鎿–⎆‚Íu¬lŠúADHDŒŸ¸iA-ADHDjv‚ðŽg—p‚µ‚½BƒZƒNƒVƒ…ƒAƒ‹ƒ}ƒCƒmƒŠƒeƒB‚²‚Æ‚ÉC ADHD“¾“_‚ƉºˆÊŽÚ“xu•s’ˆÓvu‘½“®«vuÕ“®«v“¾“_‚ɂ‚¢‚ÄtŒŸ’èCƒJƒbƒgƒIƒt54“_ˆÈã‚Ìl”‚ɂ‚¢‚Äx2ŒŸ’è‚ðs‚Á‚½B‘S‚ẴZƒNƒVƒ…ƒAƒ‹ƒ}ƒCƒmƒŠƒeƒB‚Å—LˆÓ‚ÉADHD‚ƉºˆÊŽÚ“x“¾“_‚ª‚‚­CƒJƒbƒgƒIƒt“¾“_ˆÈã‚Ìl”‚à—LˆÓ‚É‘½‚©‚Á‚½B‚È‚¨ƒgƒ‰ƒ“ƒXƒE[ƒ}ƒ“‚ƃgƒ‰ƒ“ƒXƒ}ƒ“‚ÅADHD“¾“_‚âl”‚É—LˆÓ‚È·‚ÍŒ©‚ç‚ê‚È‚©‚Á‚½BˆÈã‚©‚çCƒZƒNƒVƒ…ƒAƒ‹ƒ}ƒCƒmƒŠƒeƒB‚ÆADHD‚Í–§Ú‚ÉŠÖŒW‚µ‚Ä‚¢‚鎖‚ª–¾‚ç‚©‚Æ‚È‚Á‚½B en-copyright= kn-copyright= en-aut-name=MATSUIMegumi en-aut-sei=MATSUI en-aut-mei=Megumi kn-aut-name=¼ˆä‚ß‚®‚Ý kn-aut-sei=¼ˆä kn-aut-mei=‚ß‚®‚Ý aut-affil-num=1 ORCID= affil-num=1 en-affil=Institute for Promotion of Education and Campus Life, Okayama University kn-affil=‰ªŽR‘åŠw‹³ˆç„i‹@\ en-keyword=ƒZƒNƒVƒ…ƒAƒ‹ƒ}ƒCƒmƒŠƒeƒB kn-keyword=ƒZƒNƒVƒ…ƒAƒ‹ƒ}ƒCƒmƒŠƒeƒB en-keyword=”­’BáŠQ kn-keyword=”­’BáŠQ en-keyword=ADHD kn-keyword=ADHD en-keyword=’ˆÓŒ‡”@E‘½“®Ç kn-keyword=’ˆÓŒ‡”@E‘½“®Ç END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250314 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž†E–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=3 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250321 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=— •\Ž†E‰p•¶–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=3 article-no= start-page=65 end-page=86 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250321 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Die Grundlagen der wirtschaftlichen Entwicklung des K?nigreichs Sachseni 7 und Schlu?j kn-title=ƒUƒNƒZƒ“‰¤‘ŒoÏ”­“W‚ÌŠî‘bi‚VEŠ®j en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MatsuoNobushige en-aut-sei=Matsuo en-aut-mei=Nobushige kn-aut-name=¼”ö“W¬ kn-aut-sei=¼”ö kn-aut-mei=“W¬ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw–¼—_‹³Žö END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=3 article-no= start-page=57 end-page=64 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250321 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Memorandum on Cost of sales calculation method kn-title=”„㌴‰¿ŽZ’è•û–@‚ÉŠÖ‚·‚éŠo‘ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FukeHiroyuki en-aut-sei=Fuke en-aut-mei=Hiroyuki kn-aut-name=•‰ÆOs kn-aut-sei=•‰Æ kn-aut-mei=Os aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=3 article-no= start-page=35 end-page=55 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250321 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Multinational M&A in Upstream Industry and Organizational Change en-subtitle= kn-subtitle= en-abstract= kn-abstract=@This study explores the boundary response of domestic firms faced with increased openness to new foreign multinational M&A in an intermediate-input market in a host country. We develop a theoretical framework to study the impact of new foreign multinational M&A on the wholesale price of intermediate inputs as a key market condition in the host country and explore how the intermediate-input prices affect the organizational choice of domestic firms between domestic vertical integration and outsourcing. We find that new foreign multinational M&A raises the intermediate-input prices and facilitates the firmsf choice of domestic vertical integration. en-copyright= kn-copyright= en-aut-name=SatoMisato en-aut-sei=Sato en-aut-mei=Misato kn-aut-name=²“¡”ü—¢ kn-aut-sei=²“¡ kn-aut-mei=”ü—¢ aut-affil-num=1 ORCID= affil-num=1 en-affil=Faculty of Humanities and Social Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=3 article-no= start-page=15 end-page=33 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250321 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Survival, Creation, and Disappearance of Manufacturing Firms in the First Stage of Regional Revitalization kn-title=’n•û‘n¶‘æ‚PŠú‚É‚¨‚¯‚黑¢Ž–‹ÆŠ‚Ì‘¶‘±C”­¶CÁŽ¸ en-subtitle= kn-subtitle= en-abstract=@In many local municipalities, in addition to revitalizing existing businesses and creating new businesses, attracting manufacturing plants remains an important policy for regional development. Today, unlike the attraction of heavy, large-scale industries during the period of high economic growth, there is a trend to attract companies by making the most of the region's advantages. Although the job creation effect has become smaller than in the past, many manufacturing industries remain positioned as core industries in the region. During the first period of regional revitalization, we identify what manufacturing firms have disappeared, withdrawn, appeared, or survived in what regions, and analyze the factors behind those.
@Comparing manufacturing firms in 2014 and 2019, the average of value-added and the distribution of that shows that manufacturing firms that existed in both 2014 and 2019 had the highest labor productivity. The next highest was manufacturing firms that existed in 2019, and the lowest was manufacturing firms that existed in 2014 but did not exist in 2019. In addition, the results of the logit analysis suggest that manufacturing firms with high productivity and large size tend not to disappear, and that manufacturing firms with a high degree of urbanization tend to disappear. On the other hand, a regression analysis at the city/town/village level using industry concentration by industry and urban concentration measured by population size as explanatory variables showed a positive effect on the number of manufacturing firms that had been established. kn-abstract=@’n•û‚Ɉʒu‚·‚鑽‚­‚ÌŽ©Ž¡‘Ì‚É‚¨‚¢‚Ä‚ÍC]—ˆ‚©‚ç‚ ‚鎖‹ÆŠ‚ÌŠˆ«‰»‚âV‹KŽ–‹ÆŠ‚Ì’a¶‚ɉÁ‚¦‚ÄC»‘¢Hê‚Ì—U’v‚Í’nˆæU‹»‚É‚Æ‚Á‚Ä‚¢‚Ü‚àd—v‚È­ô‚Æ‚È‚Á‚Ä‚¢‚éB¡“úC‚“xŒoϬ’·Šú‚É‚¨‚¯‚édŒú’·‘åŒ^‚ÌŽY‹Æ‚Ì—U’v‚Ƃ͈قȂèC’nˆæ—DˆÊ«‚ð‚Å‚«‚邾‚¯Šˆ—p‚µ‚½Šé‹Æ—U’v‚ÌŒXŒü‚É‚È‚Á‚Ä‚¢‚éBŒÙ—p‘noŒø‰Ê‚ÍÌ‚É”ä‚ׂĬ‚³‚­‚È‚Á‚Ä‚¢‚é‚Æ‚Í‚¢‚¦C»‘¢‹Æ‚Ì‘½‚­‚É‚¨‚¢‚ÄC’nˆæ‚ÌŠî”ÕŽY‹Æ‚Æ‚µ‚Ă̈ʒu‚¯‚ÍŽc‚Á‚Ä‚¢‚éB‘æ1Šú‚Ì’n•û‘n¶‚ÌŠúŠÔ‚ÅC‚ǂ̂悤‚È’nˆæ‚É‚¨‚¢‚ÄC‚ǂ̂悤‚È»‘¢HꂪÁŽ¸C“P‘Þ‚âoŒ»C‘¶‘±‚µ‚Ä‚¢‚é‚Ì‚©‚ðŽ¯•Ê‚µC‚»‚ê‚ç‚Ì—vˆö‚ð•ªÍ‚·‚éB
@2014”N‚Æ2019”N‚ÌŽ–‹ÆŠ‚Ì”äŠr‚É‚¨‚¢‚ÄC•t‰Á‰¿’l¶ŽY«‚Ì•½‹Ï‚Æ•ª•z‚ðŒ©‚é‚Æ2014”NC2019”N‚Æ‚à‚É‘¶Ý‚·‚鎖‹ÆŠ‚̘J“­¶ŽY«‚ªÅ‚à‚‚¢BŽŸ‚¢‚Å‚‚¢‚Ì‚ª2019”N‚É‘¶Ý‚·‚鎖‹ÆŠ‚ÅCÅ‚à’á‚©‚Á‚½‚Ì‚ª2014”N‚É‚Í‘¶Ý‚µ‚½‚ª2019”N‚É‚Í‘¶Ý‚µ‚Ä‚¢‚È‚¢Ž–‹ÆŠ‚Å‚ ‚Á‚½B‚Ü‚½ƒƒWƒbƒg•ªÍ‚ÌŒ‹‰Ê‚©‚çC¶ŽY«‚ª‚‚­Ž–‹ÆŠ‹K–Í‚ª‘å‚«‚¢‚ÆÁ–Å‚µ‚È‚¢ŒXŒü‚ª‚ ‚èC‚Ü‚½“sŽs‰»‚Ì’ö“x‚ª‚‚¢‚ÆÁ–ÅŒXŒü‚É‚ ‚邱‚Æ‚ª„’肳‚ꂽB‘¼•ûC”­¶‚µ‚½»‘¢Ž–‹ÆŠ‚ɂ‚¢‚ÄCŽY‹Æ•Ê‚É“¯‹ÆŽíWÏ‚ÆlŒû‹K–Í‚Å‘ª‚Á‚½“sŽsWÏ‚ðà–¾•Ï”‚Æ‚µ‚½Žs’¬‘º’PˆÊ‚̉ñ‹A•ªÍ‚©‚ç‚ͳ‚ÌŒø‰Ê‚ªŽ¦‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=NakamuraRyohei en-aut-sei=Nakamura en-aut-mei=Ryohei kn-aut-name=’†‘º—Ç•½ kn-aut-sei=’†‘º kn-aut-mei=—Ç•½ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=3 article-no= start-page=1 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250321 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Market Segmentation and Market Reactions to Earnings Announcements: A Quarterly Analysis kn-title=Žsê‹æ•ª‚ÆŒˆŽZ”­•\‚ɑ΂·‚éŽsê‚Ì”½‰ž \Žl”¼Šúƒf[ƒ^‚ð—˜—p‚µ‚½•ªÍ\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The purpose of this paper is to examine, using quarterly financial data, how the market reaction to earnings announcements in each market segment iprime market segment, standard market segment, and growth market segmentj has changed after the revision of market segmentation at the Tokyo Stock Exchange. For the research design, the abnormal volume and residual returns for the 12 quarters around April 1, 2022, when the market segmentation was changed, were calculated using the analysis method of Beaver et al. m2020n. The results of the analysis suggest that volume is significantly affected by changes in market segmentation. In addition, for the group of stocks in the growth market, there appears to have been some change in the trend of stock price fluctuations after the market segmentation revision. en-copyright= kn-copyright= en-aut-name=NakagawaToyotaka en-aut-sei=Nakagawa en-aut-mei=Toyotaka kn-aut-name=’†ì–L—² kn-aut-sei=’†ì kn-aut-mei=–L—² aut-affil-num=1 ORCID= en-aut-name=YamanishiYuki en-aut-sei=Yamanishi en-aut-mei=Yuki kn-aut-name=ŽR¼—C‹G kn-aut-sei=ŽR¼ kn-aut-mei=—C‹G aut-affil-num=2 ORCID= en-aut-name=KobayashiHiroaki en-aut-sei=Kobayashi en-aut-mei=Hiroaki kn-aut-name=¬—Ñ—T–¾ kn-aut-sei=¬—Ñ kn-aut-mei=—T–¾ aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil=ŒF–{Œ§—§‘åŠw‘‡ŠÇ—Šw•” affil-num=3 en-affil= kn-affil=ÂŽRŠw‰@‘åŠw‘åŠw‰@‰ïŒvƒvƒƒtƒFƒbƒVƒ‡ƒ“Œ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=56 cd-vols= no-issue=3 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250321 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž†E–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue=9 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160908 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=S-nitrosylation of laforin inhibits its phosphatase activity and is implicated in Lafora disease en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recently, the relation between S-nitrosylation by nitric oxide (NO), which is over?produced under pathological conditions and neurodegenerative diseases, includingAlzheimerfs and Parkinsonfs diseases, has become a focus of attention. Although mostcases of Parkinsonfs disease are known to be caused by mutations in the Parkin gene, arecent finding has indicated that S-nitrosylation of Parkin affects its enzymatic activityand leads to the Parkinsonian phenotype. Therefore, it is important to understand thefunction of S-nitrosylated proteins in the pathogenesis of neurodegenerative diseases.Lafora disease (LD, OMIM 254780) is a neurodegenerative disease characterized by theaccumulation of insoluble glucans called Lafora bodies (LBs). LD is caused by mutationsin genes that encode the glucan phosphatase, Laforin, or the E3 ubiquitin ligase, Malin.In this study, we hypothesized that LD may be caused by S-nitrosylation of Laforin,which is similar to the finding that Parkinsonfs disease is caused by S-nitrosylation ofParkin. To test this hypothesis, we first determined whether Laforin was S-nitrosylatedusing a biotin switch assay, and compared the three main functions of unmodified andS-nitrosylated Laforin, namely glucan- and Malin-binding activity and phosphataseactivity. Furthermore, we examined whether the numbers of LBs were changed byNO in the cells expressing wild-type Laforin. Here, we report for the first time thatS-nitrosylation of Laforin inhibited its phosphatase activity and that LB formation wasincreased by an NO donor. Our results suggest a possible hypothesis for LD pathogenesis; that is, the decrease in phosphatase activity of Laforin by S-nitrosylation leads toincreased LB formation. Therefore, LD may be caused not only by mutations in theLaforin or Malin genes, but also by the S-nitrosylation of Laforin. en-copyright= kn-copyright= en-aut-name=ToyotaRikako en-aut-sei=Toyota en-aut-mei=Rikako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HonjoYasuko en-aut-sei=Honjo en-aut-mei=Yasuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ImajoRisa en-aut-sei=Imajo en-aut-mei=Risa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SatohAyano en-aut-sei=Satoh en-aut-mei=Ayano kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University; Research Institute for Radiation Biology and Medicine, Hiroshima University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University; Research Institute for Radiation Biology and Medicine, Hiroshima University kn-affil= affil-num=4 en-affil=Graduate School of Natural Science and Technology, Okayama University; Research Institute for Radiation Biology and Medicine, Hiroshima University kn-affil= en-keyword=S-Nitrosylation Of Laforin kn-keyword=S-Nitrosylation Of Laforin en-keyword=Post-Translational Modification kn-keyword=Post-Translational Modification en-keyword=Nitrosylation kn-keyword=Nitrosylation en-keyword=Phosphatase kn-keyword=Phosphatase en-keyword=Glucan-Binding kn-keyword=Glucan-Binding END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue=25 article-no= start-page=4757 end-page=4773 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Recent development of azahelicenes showing circularly polarized luminescence en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recently, a variety of circularly polarized luminescence (CPL) dyes have been developed as next-generation chiroptical materials. Helicenes, ortho-fused aromatics, have been recognized as some of the most promising CPL dyes. Although typical carbohelicenes show CPL, weak fluorescence is often emitted in the blue region. In contrast, heteroatom-embedded helicenes (heterohelicenes) can show intense fluorescence and CPL in the visible region because heteroatoms alter the electronic states of helicene frameworks. Among various heterohelicenes, nitrogen-embedded helicenes (azahelicenes) have unique features such as facile functionalization and sensitive responses to acid/base or metal ions. Furthermore, polycyclic aromatic hydrocarbons (PAHs) containing azaborine units have been recognized as excellent luminescent materials, and the helical derivatives, B,N-embedded helicenes, have been rapidly growing recently. In this feature article, we review and summarize the synthesis and chiroptical properties of azahelicenes, which are classified into imine-type and amine-type azahelicenes and B,N-embedded helicenes. CPL switching systems of azahelicenes are also reviewed. en-copyright= kn-copyright= en-aut-name=MaedaChihiro en-aut-sei=Maeda en-aut-mei=Chihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=EmaTadashi en-aut-sei=Ema en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Examining the Long-Term Impact of COVID-19-Induced Clinical Practice Changes on Problem-Solving Behaviors Among Newly Graduated Nurses: A Longitudinal Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective: This study aimed to longitudinally examine how the cancellation or modification of the clinical practicum due to COVID-19 affected the nursing practice competence of newly graduated nurses in Japan.
Methods: A survey was conducted across three periods-June, September, and December 2022-to seek responses from participants. A total of 73 participants (two men and 71 women) who responded in all periods were included in the analysis. The survey included questions on the impact of the integrated and specific clinical practicums, including a self-assessment scale for nursing problem-solving behaviors.
Results: During all response periods, those whose practicums were entirely clinical scored significantly higher in nursing problem-solving behaviors. Furthermore, by December, "psychological support to patients for overcoming challenges" improved alongside the clinical experience of newly graduated nurses. However, their practical skills related to aggregating information, identifying improvements in nursing problems, facilitating smooth patient interactions, and individualizing assistance were challenging to improve along with clinical experience.
Conclusion: This study revealed that canceling or modifying the clinical practicum owing to COVID-19 impacted the problem-solving behaviors of newly graduated nurses. en-copyright= kn-copyright= en-aut-name=OhueTakashi en-aut-sei=Ohue en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhueYuka en-aut-sei=Ohue en-aut-mei=Yuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HaradaHiroe en-aut-sei=Harada en-aut-mei=Hiroe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences and Faculty of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Faculty of Nursing, Department of Nursing, Hyogo University kn-affil= affil-num=3 en-affil=Faculty of Nursing, Department of Nursing, Hyogo University kn-affil= en-keyword=COVID-19 kn-keyword=COVID-19 en-keyword=clinical practice kn-keyword=clinical practice en-keyword=newly graduated nurses kn-keyword=newly graduated nurses en-keyword=nursing practice skills kn-keyword=nursing practice skills en-keyword=longitudinal study kn-keyword=longitudinal study END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=5 article-no= start-page=2421 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250224 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Deep Reinforcement Learning for Dynamic Pricing and Ordering Policies in Perishable Inventory Management en-subtitle= kn-subtitle= en-abstract= kn-abstract=Perishable goods have a limited shelf life, and inventory should be discarded once it exceeds its shelf life. Finding optimal inventory management policies is essential since inefficient policies can lead to increased waste and higher costs. While many previous studies assume the perishable inventory is processed following the First In, First Out rule, it does not reflect customer purchasing behavior. In practice, customers' preferences are influenced by the shelf life and price of products. This study optimizes inventory and pricing policies for a perishable inventory management problem considering age-dependent probabilistic demand. However, introducing dynamic pricing significantly increases the complexity of the problem. To tackle this challenge, we propose eliminating irrational actions in dynamic programming without sacrificing optimality. To solve this problem more efficiently, we also implement a deep reinforcement learning algorithm, proximal policy optimization, to solve this problem. The results show that dynamic programming with action reduction achieved an average of 63.1% reduction in computation time compared to vanilla dynamic programming. In most cases, proximal policy optimization achieved an optimality gap of less than 10%. Sensitivity analysis of the demand model revealed a negative correlation between customer sensitivity to shelf lives or prices and total profits. en-copyright= kn-copyright= en-aut-name=NomuraYusuke en-aut-sei=Nomura en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=LiuZiang en-aut-sei=Liu en-aut-mei=Ziang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NishiTatsushi en-aut-sei=Nishi en-aut-mei=Tatsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=reinforcement learning kn-keyword=reinforcement learning en-keyword=supply chain kn-keyword=supply chain en-keyword=inventory management kn-keyword=inventory management en-keyword=perishable inventory kn-keyword=perishable inventory en-keyword=dynamic pricing kn-keyword=dynamic pricing END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=1 article-no= start-page=36 end-page=43 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=2025 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Evaluation of the temporal behavior of fulvic acid iron in Asahi River, Okayama, Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=Iron is essential for biogeochemical processes in aquatic ecosystems, but its riverine concentration can be affected by environmental conditions. This study assessed weekly fulvic acid iron (FAFe) concentration at a single sampling site in Asahi River from 2022?2023 to explore the differences in the temporal scales. The objectives of this study were to evaluate the effects of physicochemical properties of the river on the concentration of FAFe, analyze the concentration of FAFe in spring, summer, autumn and winter, and assess the relationship between FAFe concentration and land use types of the watershed. The results indicated that physicochemical parameters, such as pH and surface water temperature (SWT) seemed to influence FAFe concentration (p < 0.05). Hydrological dynamics influenced FAFe concentration and transport, revealing an increasing trend during spring (p < 0.001) and summer (p = 0.05), with non-significant trends during autumn and winter (p > 0.05). FAFe exhibited a strong positive correlation with total organic carbon (TOC) (p < 0.001). Upland fields significantly influenced FAFe concentration (p < 0.01) through runoff with abundant NO3? and PO43? into the river. Thus, FAFe concentration in Asahi River was influenced by pH, SWT, TOC, hydrological regime, and agricultural runoff. en-copyright= kn-copyright= en-aut-name=YengehRohdof Lactem en-aut-sei=Yengeh en-aut-mei=Rohdof Lactem kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SomuraHiroaki en-aut-sei=Somura en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MoroizumiToshitsugu en-aut-sei=Moroizumi en-aut-mei=Toshitsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoriYasushi en-aut-sei=Mori en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MaedaMorihiro en-aut-sei=Maeda en-aut-mei=Morihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= en-keyword=dissolved iron kn-keyword=dissolved iron en-keyword=seasonal variation kn-keyword=seasonal variation en-keyword=dissolved organic matter kn-keyword=dissolved organic matter en-keyword=fulvic acid iron kn-keyword=fulvic acid iron END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue= article-no= start-page=85 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Personal Networks and Social Support in Relation to Age of Elderly Women kn-title=‚—î—«‚̃p[ƒ\ƒiƒ‹Eƒlƒbƒgƒ[ƒN‚ƃ\[ƒVƒƒƒ‹EƒTƒ|[ƒg‚Ì”N—î‚É‚æ‚éˆá‚¢‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= 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Geranylgeranylacetone (GGA) is a main component of teprenone, a gastric mucosal protectant commonly used in clinical practice. In preclinical models, GGA suppresses proinflammatory cytokines, including interleukin (IL)-1ƒÀ, IL-6, and tumor necrosis factor-ƒ¿ (TNF-ƒ¿), which are associated with GVHD as well as induces thioredoxin-1 (Trx-1), which suppresses GVHD while maintaining GVL effects. Here, we investigated whether the addition of teprenone to standard GVHD prophylaxis could reduce the cumulative incidence of severe acute GVHD (aGVHD) without attenuating GVL effects. This open-label, randomized clinical trial enrolled 40 patients (21 control and 19 teprenone group) who received allo-HSCT between May 2022 and February 2023 in our institution. Patients in the teprenone group received 50 mg of teprenone orally thrice daily for 21 days from the initiation of the conditioning regimen. The cumulative incidence of severe aGVHD by day 100 after allo-HSCT was not significantly different in the two groups (27.9 vs. 16.1%, p?=?0.25). The exploratory studies revealed no obvious changes in Trx-1 levels, but the alternations from baseline in IL-1ƒÀ and TNF-ƒ¿ levels at day 28 after allo-HSCT tended to be lower in the teprenone group. In conclusion, we could not demonstrate that teprenone significantly prevented the development of severe aGVHD. Discrepancy with preclinical model suggests that appropriate dose of teprenone may be necessary to induce the expression of antioxidant enzymes that suppress severe aGVHD. Clinical Trial Registration number:jRCTs 061210072. en-copyright= kn-copyright= en-aut-name=KitamuraWataru en-aut-sei=Kitamura en-aut-mei=Wataru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujiiKeiko en-aut-sei=Fujii en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TsugeMitsuru en-aut-sei=Tsuge en-aut-mei=Mitsuru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MitsuhashiToshiharu en-aut-sei=Mitsuhashi en-aut-mei=Toshiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KobayashiHiroki en-aut-sei=Kobayashi en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KamoiChihiro en-aut-sei=Kamoi en-aut-mei=Chihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamamotoAkira en-aut-sei=Yamamoto en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KondoTakumi en-aut-sei=Kondo en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SeikeKeisuke en-aut-sei=Seike en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=FujiwaraHideaki en-aut-sei=Fujiwara en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AsadaNoboru en-aut-sei=Asada en-aut-mei=Noboru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=EnnishiDaisuke en-aut-sei=Ennishi en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=MatsuokaKen-ichi en-aut-sei=Matsuoka en-aut-mei=Ken-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=FujiiNobuharu en-aut-sei=Fujii en-aut-mei=Nobuharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= affil-num=1 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Pediatric Acute Diseases, Okayama University Academic Field of Medicine Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=8 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=10 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=11 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=12 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=13 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=14 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= affil-num=15 en-affil=Department of Hematology and Oncology, Okayama University Hospital kn-affil= en-keyword=Allogeneic hematopoietic stem cell transplantation kn-keyword=Allogeneic hematopoietic stem cell transplantation en-keyword=Graft-versus-host disease kn-keyword=Graft-versus-host disease en-keyword=Teprenone kn-keyword=Teprenone en-keyword=Oxidative stress kn-keyword=Oxidative stress en-keyword=Interleukin-33 kn-keyword=Interleukin-33 END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=6666 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250224 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Microfluidic fabrication of rattle shaped biopolymer microcapsules via sequential phase separation in oil droplets en-subtitle= kn-subtitle= en-abstract= kn-abstract=Multilayer microcapsules containing a small particle within a larger capsule have recently attracted considerable attention owing to their potential applications in diverse fields, including drug delivery, active ingredient storage, and chemical reactions. These complex capsules have been fabricated using interfacial polymerization or seeded emulsion polymerization. However, these methods often require complex and lengthy polymerization processes, limiting their utility, particularly in biopolymer systems. This study introduces a simple and efficient approach for preparing rattle-shaped cellulose acetate (CA) microcapsules through sequential phase separation in droplets. We systematically examine the effects of various preparation parameters, including the amount of co-solvent, initial droplet size, and flow rates, and reveal that the incorporation of a co-solvent-ethyl acetate (EA)- in the dispersed phase significantly impacts the microcapsule morphology. Our findings demonstrate a transition from a core-shell to a rattle-shaped structure as the EA concentration increases. Furthermore, the initial droplet diameter and flow rates influence microcapsule formation-larger droplets and reduced continuous-phase flow rates favor the development of multi-layered structures. These results indicate that the formation mechanism of these rattle-shaped microcapsules arises from the establishment of a radial solvent concentration gradient and subsequent phase separation within the droplets, driven by kinetic rather than thermodynamic factors. en-copyright= kn-copyright= en-aut-name=WatanabeTakaichi en-aut-sei=Watanabe en-aut-mei=Takaichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakaiYuko en-aut-sei=Sakai en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MoriKurumi en-aut-sei=Mori en-aut-mei=Kurumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OnoTsutomu en-aut-sei=Ono en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Applied Chemistry, Graduate School of Environmental, Life, Natural Science and Technology kn-affil= affil-num=2 en-affil=Department of Applied Chemistry, Graduate School of Environmental, Life, Natural Science and Technology kn-affil= affil-num=3 en-affil=Department of Applied Chemistry, Graduate School of Environmental, Life, Natural Science and Technology kn-affil= affil-num=4 en-affil=Department of Applied Chemistry, Graduate School of Environmental, Life, Natural Science and Technology kn-affil= en-keyword=Microfluidics kn-keyword=Microfluidics en-keyword=Phase separation kn-keyword=Phase separation en-keyword=Nucleation kn-keyword=Nucleation en-keyword=Multi-core kn-keyword=Multi-core en-keyword=Rattle-shaped kn-keyword=Rattle-shaped END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=2 article-no= start-page=61 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250129 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Study of Podoplanin-Deficient Mouse Bone with Mechanical Stress en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective: We investigated morphological differences in osteocyte processes between aged mice and our original podoplanin-conditional knockout (cKO) mice in which the floxed exon 3 of podoplanin was deleted by Dmp-1-driven Cre (Dmp1-Cre;Pdpnƒ¢/ƒ¢). Methods: SEM observation on osteocyte cell process, histochemistry for bone remodeling with mechanostress, and RT-PCR for RANKL and M-CSF in podoplanin cKO mouse bone with mechanostress was investigated. Results: SEM observations showed fewer and thinner osteocyte processes in femurs from 23-week-old Dmp1-Cre;Pdpnƒ¢/ƒ¢ mice than from 23-week-old wild-type mice, while the numbers of osteocyte processes in femurs and calvarias were similar in 23-week-old Dmp1-Cre;Pdpnƒ¢/ƒ¢ mice and 48-week-old wild-type mice. Furthermore, cell process numbers in femurs and calvarias were significantly smaller in 23-week-old Dmp1-Cre;Pdpnƒ¢/ƒ¢ mice than in 48-week-old wild-type mice. In the test for differences in alveolar bone resorption under mechanical stress between Dmp1-Cre;Pdpnƒ¢/ƒ¢ and wild-type mice, the area of TRAP-positive resorption pits was larger in wild-type mice than in Dmp1-Cre;Pdpnƒ¢/ƒ¢ mice. In a quantitative tissue PCR analysis, the mRNA expression levels of RANKL and M-CSF in alveolar bone under mechanical stress were significantly lower in Dmp1-Cre;Pdpnƒ¢/ƒ¢ mice than in wild-type mice. These results suggest that a reduction in cell process formation in osteocytes with podoplanin cKO affected the absorption of alveolar bone under mechanical stress in Dmp1-Cre;Pdpnƒ¢/ƒ¢ mice. Conclusions: In podoplanin-deficient bone, the deformation of osteocyte processes by mechanical stimuli is not recognized as a stress due to the lower number of cell processes with podoplanin deficiency; therefore, the production of osteoclast migration/differentiation factors by activated osteocytes is not fully induced and macrophage migration to alveolar bone with mechanical stress appeared to be suppressed. These results indicate that podoplanin-dependent osteocyte process formation indirectly plays a key role in sensing mechanical stress in bone. en-copyright= kn-copyright= en-aut-name=KanaiTakenori en-aut-sei=Kanai en-aut-mei=Takenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OsawaKyoko en-aut-sei=Osawa en-aut-mei=Kyoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KajiwaraKoichiro en-aut-sei=Kajiwara en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SatoYoshiaki en-aut-sei=Sato en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SawaYoshihiko en-aut-sei=Sawa en-aut-mei=Yoshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Orthodontics, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University kn-affil= affil-num=2 en-affil=Department of Orthodontics, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University kn-affil= affil-num=3 en-affil=Department of Oral Growth & Development, Hokkaido University kn-affil= affil-num=4 en-affil=Department of Orthodontics, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University kn-affil= affil-num=5 en-affil=Department of Oral Function & Anatomy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=podoplanin kn-keyword=podoplanin en-keyword=cKO kn-keyword=cKO en-keyword=osteocyte kn-keyword=osteocyte en-keyword=bone kn-keyword=bone en-keyword=remodeling kn-keyword=remodeling END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=2 article-no= start-page=267 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250122 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Abnormal Expression of Tubular SGLT2 and GULT2 in Diabetes Model Mice with Malocclusion-Induced Hyperglycemia en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: A relationship between malocclusion and the promotion of diabetes has been suggested. In hyperglycemia, the expression of sodium-glucose cotransporter 2 (SGLT2) and the facilitative glucose transporter 2 (GLUT2) is upregulated in proximal tubular cells, leading to an increase in renal glucose reabsorption. The present study aimed to investigate whether malocclusion contributes to diabetic exacerbation. Methods: Streptozotocin (STZ)-induced diabetic mice with malocclusion due to cutting molars were investigated based on increased blood glucose levels. PCR and immunohistochemical analyses were performed on diabetic mice kidneys to investigate the expression of SGLT2 and GLUT2. Results: Animal experiments were performed using 32 mice for 21 days. The time to reach a diabetic condition in STZ-administered mice was shorter with malocclusion than without malocclusion. The increase and mean blood glucose levels in STZ-administered mice were steeper and higher with malocclusion than without malocclusion. Urea albumin, BUN, and CRE levels were higher in diabetic mice with malocclusion than in diabetic mice without. Immunoreaction with anti-SGLT2 and anti-GLUT2 in the renal tissue of STZ-administered mice was stronger with malocclusion than without malocclusion. The amounts of SGLT2 and GLUT2 mRNA in the renal tissue in STZ-administered mice were higher with malocclusion than without malocclusion. The amounts of TNF-a and IL-6 mRNA in the large intestinal tissue in STZ-administered mice were higher with malocclusion than without malocclusion. Conclusions: Our results indicate that malocclusion accelerates the tubular expression of SGLT2 and GLUT2 under hyperglycemia. Malocclusion may be a diabetes-exacerbating factor with increased poor glycemic control due to shortened occlusion time resulting from swallowing food without chewing. en-copyright= kn-copyright= en-aut-name=KajiwaraKoichiro en-aut-sei=Kajiwara en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TamaokiSachio en-aut-sei=Tamaoki en-aut-mei=Sachio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SawaYoshihiko en-aut-sei=Sawa en-aut-mei=Yoshihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Oral Growth & Development, Fukuoka Dental College kn-affil= affil-num=2 en-affil=Department of Oral Growth & Development, Fukuoka Dental College kn-affil= affil-num=3 en-affil=Department of Oral Function & Anatomy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=malocclusion kn-keyword=malocclusion en-keyword= hyperglycemia kn-keyword= hyperglycemia en-keyword= SGLT2 kn-keyword= SGLT2 en-keyword= GLUT2 kn-keyword= GLUT2 END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=2 article-no= start-page=235 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250205 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Distinct Infection Mechanisms of Rhizoctonia solani AG-1 IA and AG-4 HG-I+II in Brachypodium distachyon and Barley en-subtitle= kn-subtitle= en-abstract= kn-abstract=Rhizoctonia solani is a basidiomycete phytopathogenic fungus that causes rapid necrosis in a wide range of crop species, leading to substantial agricultural losses worldwide. The species complex is divided into 13 anastomosis groups (AGs) based on hyphal fusion compatibility and further subdivided by culture morphology. While R. solani classifications were shown to be independent of host specificity, it remains unclear whether different R. solani isolates share similar virulence mechanisms. Here, we investigated the infectivity of Japanese R. solani isolates on Brachypodium distachyon and barley. Two isolates, AG-1 IA (from rice) and AG-4 HG-I+II (from cauliflower), infected leaves of both plants, but only AG-4 HG-I+II infected roots. B. distachyon accessions Bd3-1 and Gaz-4 and barley cultivar 'Morex' exhibited enhanced resistance to both isolates compared to B. distachyon Bd21 and barley cultivars 'Haruna Nijo' and 'Golden Promise'. During AG-1 IA infection, but not AG-4 HG-I+II infection, resistant Bd3-1 and Morex induced genes for salicylic acid (SA) and N-hydroxypipecolic acid (NHP) biosynthesis. Pretreatment with SA or NHP conferred resistance to AG-1 IA, but not AG-4 HG-I+II, in susceptible B. distachyon Bd21 and barley Haruna Nijo. On the leaves of susceptible Bd21 and Haruna Nijo, AG-1 IA developed extensive mycelial networks with numerous infection cushions, which are specialized infection structures well-characterized in rice sheath blight. In contrast, AG-4 HG-I+II formed dispersed mycelial masses associated with underlying necrosis. We propose that the R. solani species complex encompasses at least two distinct infection strategies: AG-1 IA exhibits a hemibiotrophic lifestyle, while AG-4 HG-I+II follows a predominantly necrotrophic strategy. en-copyright= kn-copyright= en-aut-name=MahadevanNiranjan en-aut-sei=Mahadevan en-aut-mei=Niranjan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FernandaRozi en-aut-sei=Fernanda en-aut-mei=Rozi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KouzaiYusuke en-aut-sei=Kouzai en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KohnoNatsuka en-aut-sei=Kohno en-aut-mei=Natsuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NagaoReiko en-aut-sei=Nagao en-aut-mei=Reiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NyeinKhin Thida en-aut-sei=Nyein en-aut-mei=Khin Thida kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=WatanabeMegumi en-aut-sei=Watanabe en-aut-mei=Megumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SakataNanami en-aut-sei=Sakata en-aut-mei=Nanami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MatsuiHidenori en-aut-sei=Matsui en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=ToyodaKazuhiro en-aut-sei=Toyoda en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IchinoseYuki en-aut-sei=Ichinose en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MochidaKeiichi en-aut-sei=Mochida en-aut-mei=Keiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=HisanoHiroshi en-aut-sei=Hisano en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=NoutoshiYoshiteru en-aut-sei=Noutoshi en-aut-mei=Yoshiteru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Crop Stress Management Group, Division of Plant Molecular Regulation Research, Institute of Agrobiological Sciences, National Agriculture and Food Research Organization (NARO) kn-affil= affil-num=4 en-affil=Faculty of Agriculture, Okayama University kn-affil= affil-num=5 en-affil=Faculty of Agriculture, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=7 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=8 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=9 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=10 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=11 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=12 en-affil=RIKEN Center for Sustainable Resource Science kn-affil= affil-num=13 en-affil=Institute of Plant Science and Resources, Okayama University kn-affil= affil-num=14 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=Rhizoctonia solani species complex kn-keyword=Rhizoctonia solani species complex en-keyword=virulence mechanism kn-keyword=virulence mechanism en-keyword=infection behavior kn-keyword=infection behavior en-keyword=salicylic acid kn-keyword=salicylic acid en-keyword=N-hydroxypipecolic acid kn-keyword=N-hydroxypipecolic acid END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue=2 article-no= start-page=101 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Radiographic and Clinical Assessment of Unidirectional Porous Beta-Tricalcium Phosphate to Treat Benign Bone Tumors en-subtitle= kn-subtitle= en-abstract= kn-abstract=The purpose of this study was to evaluate radiographic changes, clinical outcomes, and complications following unidirectional porous beta-tricalcium phosphate (UDPTCP) implantation for the treatment of benign bone tumors. We retrospectively analyzed 46 patients who underwent intralesional resection. The patients were divided into two cohorts: Cohort 1 (n = 32), which included all bones except the phalanges and metacarpal/tarsal bones, and Cohort 2 (n = 14), which included the phalanges and metacarpal/tarsal bones. Radiographic changes were assessed at each reading based on resorption of the implanted UDPTCP and bone trabeculation through the defect. UDPTCP resorption and bone trabeculation were observed on radiographs within 3 months of surgery in all patients. Bone remodeling in the cavity progressed steadily for up to 3 years postoperatively. In Cohort 1, resorption and trabeculation progressed significantly in young patients, and trabeculation developed significantly in small lesions. The rates of resorption and trabeculation at 3 months postoperatively correlated statistically with their increased rates at one year. There was no statistical difference in resorption and trabeculation rates between Cohort 1 and Cohort 2. There were no cases of postoperative deep infections or allergic reactions related to the implant. UDPTCP is a useful bone-filling substitute for the treatment of benign bone tumors and has a low complication rate. en-copyright= kn-copyright= en-aut-name=KunisadaToshiyuki en-aut-sei=Kunisada en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakataEiji en-aut-sei=Nakata en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiwaraTomohiro en-aut-sei=Fujiwara en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KatayamaHaruyoshi en-aut-sei=Katayama en-aut-mei=Haruyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ItanoTakuto en-aut-sei=Itano en-aut-mei=Takuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KurozumiTakanao en-aut-sei=Kurozumi en-aut-mei=Takanao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AndoTeruhiko en-aut-sei=Ando en-aut-mei=Teruhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=unidirectional porous beta-tricalcium phosphate kn-keyword=unidirectional porous beta-tricalcium phosphate en-keyword= bone tumor kn-keyword= bone tumor en-keyword= bone graft kn-keyword= bone graft en-keyword= radiography kn-keyword= radiography en-keyword= bone remodeling kn-keyword= bone remodeling END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=e202403213 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250218 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Antifouling Activity of Xylemin, Its Structural Analogs, and Related Polyamines en-subtitle= kn-subtitle= en-abstract= kn-abstract=Biofouling, which is the accumulation of organisms on undersea structures, poses significant global, social, and economic issues. Although organotin compounds were effective antifoulants since the 1960s, they were banned in 2008 due to their toxicity to marine life. Although tin-free alternatives have been developed, they also raise environmental concerns. This underscores the need for effective, nontoxic antifouling agents. We previously synthesized N-(4-aminobutyl)propylamine (xylemin) and its structural analogs. In this study, we assayed the antifouling activity and toxicity of xylemin, its structural analogs, and related polyamines toward cypris larvae of the barnacle Amphibalanus amphitrite. Xylemin and its Boc-protected analog exhibited antifouling activities with 50% effective concentrations (EC50) of 4.25 and 6.11 ?g/mL, respectively. Four xylemin analogs did not show a settlement-inhibitory effect at a concentration of 50 ?g/mL. Putrescine, spermidine, spermine, and thermospermine, which are xylemin-related polyamines, did not display antifoulant effects (EC50 > 50 ?g/mL). All evaluated compounds were nontoxic at a concentration of 50 ?g/mL. These findings indicate that the size and structure of the N-alkyl group are essential for the antifouling activity of xylemin. Therefore, xylemin and its analogs hold promise as nontoxic, eco-friendly antifouling agents, offering a sustainable solution to biofouling in marine environments. en-copyright= kn-copyright= en-aut-name=TakamuraHiroyoshi en-aut-sei=Takamura en-aut-mei=Hiroyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YorisueTakefumi en-aut-sei=Yorisue en-aut-mei=Takefumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TanakaKenta en-aut-sei=Tanaka en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KadotaIsao en-aut-sei=Kadota en-aut-mei=Isao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Institute of Natural and Environmental Sciences, University of Hyogo kn-affil= affil-num=3 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=4 en-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=Amines kn-keyword=Amines en-keyword=Antifouling activity kn-keyword=Antifouling activity en-keyword=Barnacle kn-keyword=Barnacle en-keyword=Structure?activity relationships kn-keyword=Structure?activity relationships en-keyword=Xylemin kn-keyword=Xylemin END start-ver=1.4 cd-journal=joma no-vol=197 cd-vols= no-issue= article-no= start-page=115301 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202503 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Fraglide-1 from traditional Chinese aromatic vinegar: A natural AhR antagonist for atopic dermatitis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Traditional Chinese Zhenjiang aromatic vinegar (Kozu) contains Fraglide-1 (FG1), a bioactive lactone with demonstrated peroxisome proliferator-activated receptor gamma (PPARƒÁ) agonist and antioxidant activities. This study explored FG1's novel ability to antagonize the aryl hydrocarbon receptor (AhR) signaling pathway, which regulates artemin expression and contributes to itching and inflammation in atopic dermatitis. Through molecular docking simulations and cell-based assays in human keratinocytes, we demonstrated FG1's potent antagonistic activity against AhR signaling. FG1 effectively suppressed FICZ-induced inflammatory responses, including artemin expression, with potency (half maximal inhibitory concentration, IC50 = 5.1 ƒÊM) comparable to the synthetic antagonist StemRegenin 1 (SR1) while demonstrating a superior safety profile (median lethal concentration, LC50 > 100 ƒÊM vs. 27.5 ƒÊM for SR1). These findings expand our understanding of bioactive compounds from traditional fermented foods and their regulatory effects on AhR signaling, providing a foundation for future studies on FG1's role in modulating skin inflammation. en-copyright= kn-copyright= en-aut-name=KatoKosuke en-aut-sei=Kato en-aut-mei=Kosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AkamatsuMiki en-aut-sei=Akamatsu en-aut-mei=Miki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KakimaruSaya en-aut-sei=Kakimaru en-aut-mei=Saya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KoreishiMayuko en-aut-sei=Koreishi en-aut-mei=Mayuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakagiMasahiro en-aut-sei=Takagi en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyashitaMasahiro en-aut-sei=Miyashita en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MurataYoshiyuki en-aut-sei=Murata en-aut-mei=Yoshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NakamuraYoshimasa en-aut-sei=Nakamura en-aut-mei=Yoshimasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SatohAyano en-aut-sei=Satoh en-aut-mei=Ayano kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TsujinoYoshio en-aut-sei=Tsujino en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=5 en-affil=School of Materials Science, Japan Advanced Institute of Science and Technology kn-affil= affil-num=6 en-affil=Graduate School of Agriculture, Kyoto University kn-affil= affil-num=7 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=8 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=9 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=10 en-affil=Graduate School of Science, Technology and Innovation, Kobe University kn-affil= en-keyword=AhR kn-keyword=AhR en-keyword=Xenobiotic responsive element kn-keyword=Xenobiotic responsive element en-keyword=StemRegenin 1 kn-keyword=StemRegenin 1 en-keyword=ARNT kn-keyword=ARNT en-keyword=Atopic dermatitis kn-keyword=Atopic dermatitis en-keyword=Artemin kn-keyword=Artemin END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=8 article-no= start-page=e202418546 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250122 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=B,N]Embedded Helical Nanographenes Showing an Ion]Triggered Chiroptical Switching Function en-subtitle= kn-subtitle= en-abstract= kn-abstract=Intramolecular oxidative aromatic coupling of 3,6-bis(m-terphenyl-2f-yl)carbazole provided a bis(m-terphenyl)-fused carbazole, while that of 3,6-bis(m-terphenyl-2f-yl)-1,8-diphenylcarbazole afforded a bis(quaterphenyl)-fused carbazole. Borylation of the latter furnished a B,N-embedded helical nanographene binding a fluoride anion via a structural change from the three-coordinate boron to the four-coordinate boron. The anionic charge derived from the fluoride anion is stabilized over the expanded ƒÎ-framework, which leads to the high binding constant (Ka) of 1~105?M?1. The four-coordinate boron species was converted back to the parent three-coordinate boron species with Ag+, and the chiroptical switch between the three-coordinate boron and four-coordinate boron species has been achieved via the ion recognition with the change in the color and glum values. en-copyright= kn-copyright= en-aut-name=MaedaChihiro en-aut-sei=Maeda en-aut-mei=Chihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MichishitaSayaka en-aut-sei=Michishita en-aut-mei=Sayaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YasutomoIssa en-aut-sei=Yasutomo en-aut-mei=Issa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=EmaTadashi en-aut-sei=Ema en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=Boron kn-keyword=Boron en-keyword=Chirality kn-keyword=Chirality en-keyword=Circularly polarized luminescence kn-keyword=Circularly polarized luminescence en-keyword=Helical nanographenes kn-keyword=Helical nanographenes en-keyword=Ion sensing kn-keyword=Ion sensing END start-ver=1.4 cd-journal=joma no-vol=111 cd-vols= no-issue=6 article-no= start-page=064502 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250204 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Josephson effect and odd-frequency pairing in superconducting junctions with unconventional magnets en-subtitle= kn-subtitle= en-abstract= kn-abstract=We consider Josephson junctions formed by coupling two conventional superconductors via an unconventional magnet and investigate the formation of Andreev bound states, their impact on the Josephson effect, and the emergent superconducting correlations. In particular, we focus on unconventional magnets known as ?-wave altermagnets and ?-wave magnets. We find that the Andreev bound states in ?-wave altermagnet and ??-wave magnet Josephson junctions strongly depend on the transverse momentum, with a spin splitting and low-energy minima as a function of the superconducting phase difference ?. In contrast, the Andreev bound states for ??-wave magnets are insensitive to the transverse momentum. We then show that the Andreev bound states can be probed by the local density of states in the middle of the junction, which also reveals that ??2??2- and ?-wave magnet junctions are prone to host zero energy peaks. While the zero-energy peak in ??2??2-wave altermagnet junctions tends to oscillate with the magnetic order, it remains robust in ?-wave magnet junctions. We then discover that the Josephson current in ?-wave altermagnet junctions is composed of higher harmonics of ?, which originate a ?-Josephson junction behavior entirely controlled by the magnetic order in ????-wave altermagnets. In contrast, the Josephson current in Josephson junctions with ?-wave magnets exhibits a conventional sinelike profile with a fast sign change at ?=? due to zero-energy Andreev bound states. We also demonstrate that the critical currents in ?-wave altermagnet Josephson junctions exhibit an oscillatory decay with the increase of the magnetic order, while the oscillations are absent in ?-wave magnet junctions albeit the currents exhibit a slow decay. Furthermore, we also demonstrate that the interplay of the Josephson effect and unconventional magnetic order of ?-wave altermagnets and ?-wave magnets originates from odd-frequency spin-triplet ?-wave superconducting correlations that are otherwise absent. Our results can serve as a guide to pursue the new functionality of Josephson junctions based on unconventional magnets. en-copyright= kn-copyright= en-aut-name=FukayaYuri en-aut-sei=Fukaya en-aut-mei=Yuri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MaedaKazuki en-aut-sei=Maeda en-aut-mei=Kazuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YadaKeiji en-aut-sei=Yada en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=CayaoJorge en-aut-sei=Cayao en-aut-mei=Jorge kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TanakaYukio en-aut-sei=Tanaka en-aut-mei=Yukio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=LuBo en-aut-sei=Lu en-aut-mei=Bo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Faculty of Environmental Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Department of Applied Physics, Nagoya University kn-affil= affil-num=3 en-affil=Department of Applied Physics, Nagoya University kn-affil= affil-num=4 en-affil=Department of Physics and Astronomy, Uppsala University kn-affil= affil-num=5 en-affil=Department of Applied Physics, Nagoya University kn-affil= affil-num=6 en-affil=Center for Joint Quantum Studies, Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, Department of Physics, Tianjin University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue=1 article-no= start-page=16 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250215 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Behavior, behavioral syndromes, and metabolism: the effects of artificial selection for death-feigning on metabolic rate en-subtitle= kn-subtitle= en-abstract= kn-abstract=Death-feigning, or thanatosis, is an anti-predator behavioral strategy in many animals. Because individuals remain immobile while feigning death, individuals with longer durations of death feigning often show lower locomotor activity. Thus, metabolic rate, which is closely related to locomotor activity, may also be related to the intensity of death feigning. If there is a genetic correlation between death feigning and metabolism, metabolic rate may respond to selection on death-feigning behavior. Here, we tested for a relationship between metabolic rate and death-feigning using replicated populations of the red flour beetle (Tribolium castaneum) subjected to artificial bidirectional selection on the duration of death-feigning behavior. The results indicated that metabolic rate did not differ between populations selected for increased or decreased death feigning, although locomotor activity was significantly different between these treatments; populations selected for reduced death-feigning durations tended to be more active. These results suggest that death-feigning behavior is not genetically correlated with metabolic rate in T. castaneum. en-copyright= kn-copyright= en-aut-name=MatsumuraKentarou en-aut-sei=Matsumura en-aut-mei=Kentarou kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HoskenDavid J. en-aut-sei=Hosken en-aut-mei=David J. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NodaTomohito en-aut-sei=Noda en-aut-mei=Tomohito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiyatakeTakahisa en-aut-sei=Miyatake en-aut-mei=Takahisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SharmaManmohan D. en-aut-sei=Sharma en-aut-mei=Manmohan D. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Centre for Ecology and Conservation, Faculty of Environment, Science and Economy, University of Exeter kn-affil= affil-num=3 en-affil=Centre for Ecology and Conservation, Faculty of Environment, Science and Economy, University of Exeter kn-affil= affil-num=4 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=5 en-affil=Centre for Ecology and Conservation, Faculty of Environment, Science and Economy, University of Exeter kn-affil= en-keyword=anti-predator behavior kn-keyword=anti-predator behavior en-keyword=artificial selection kn-keyword=artificial selection en-keyword=death-feigning kn-keyword=death-feigning en-keyword=metabolic rate kn-keyword=metabolic rate en-keyword=personality kn-keyword=personality en-keyword=Tribolium kn-keyword=Tribolium END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue=4 article-no= start-page=563 end-page=567 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202410 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Backside Irradiation of Ultraviolet-A for Correcting Nonuniformity Error of Gafchromic XR-QA2 Films en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose: Radiochromic film is used for quality assurance and quality control of X-ray equipment in the diagnostic radiology. In addition, three-dimensional dose distribution of computed tomography (CT) is measured. To correct the nonuniformity and uncertainty of radiochromic films for dose measurement of CT, the films are preirradiated ultraviolet (UV)-A rays. There is a difference in the UV protection strength of radiochromic films. A concern exists about the effects of the UV-A irradiation intensity. We thus irradiated with UV-A rays from the backsides of the films to assess if backside irradiation was possible. Materials and Methods: Gafchromic XR-QA2 and RTQA2 were used in this study. The UV-A rays were simultaneously irradiated on the front and backsides of each film for 12 h. The yellow layer of each film was scanned and imaged. The average pixel values } standard deviations (SDs) were compared. In the statistical analysis, a paired t-test was performed. To compare, the active-layer densities engendered by the UV-A rays. Calibration curve was created with 48 h of preirradiation of UV-A. Results: The mean pixel values } SD for Gafchromic XR-QA2 on the front and backsides were 130.776 } 0.812 and 81.015 } 1.128, respectively. On the other hand, the mean pixel values } SD for Gafchromic RTQA2 on the front and backsides were 62.299 } 1.077 and 133.761 } 1.365, respectively. The statistical results of the paired t-test were significantly different (P < 0.01) between both films. Fitting equation of the calibration curve is shown below. y = -390.47 } 200 + (443.45 } 10x80).5068 } 0.0434. Conclusion: Based on the relationship between the sensitivity of the active layer to UV-A rays and the strength of UV protection on the surface, we concluded that backside irradiation is recommended for Gafchromic XR-QA2, and frontside irradiation is recommended for Gafchromic RTQA2. en-copyright= kn-copyright= en-aut-name=TankiNobuyoshi en-aut-sei=Tanki en-aut-mei=Nobuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=GotoSachiko en-aut-sei=Goto en-aut-mei=Sachiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KatsudaToshizo en-aut-sei=Katsuda en-aut-mei=Toshizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GotandaRumi en-aut-sei=Gotanda en-aut-mei=Rumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=GotandaTatsuhiro en-aut-sei=Gotanda en-aut-mei=Tatsuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KuwanoTadao en-aut-sei=Kuwano en-aut-mei=Tadao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Medical Radiation Technology, Shizuoka College of Medicalcare Science kn-affil= affil-num=4 en-affil=Department of Radiological Technology, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare kn-affil= affil-num=5 en-affil=Department of Radiological Technology, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare kn-affil= affil-num=6 en-affil=Department of Radiology, Osaka Center for Cancer and Cardiovascular Diseases Prevention kn-affil= en-keyword=Backside irradiation kn-keyword=Backside irradiation en-keyword=computed tomography kn-keyword=computed tomography en-keyword=reflective type radiochromic film kn-keyword=reflective type radiochromic film en-keyword=ultraviolet radiation kn-keyword=ultraviolet radiation END start-ver=1.4 cd-journal=joma no-vol=236 cd-vols= no-issue= article-no= start-page=74 end-page=81 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Characteristics of porcine oocyte-cumulus complexes derived from various sizes of antral follicles and classified by brilliant cresyl blue staining, and developmental competence of the oocytes en-subtitle= kn-subtitle= en-abstract= kn-abstract=The present study sought to determine the characteristics of porcine oocyte-cumulus complexes (OCCs) derived from very small and small antral follicles (with less than 1 mm and 1?3 mm in diameter, respectively; VSF and SF) in comparison with controls from medium ones (with 3?6 mm in diameter; MF). Additionally, the present study examined the utility of brilliant cresyl blue (BCB) staining for assessing these OCCs. The incidence of BCB- oocytes in VSF- and SF-derived OCCs was higher than that in MF-derived OCCs. Although the meiotic and developmental competences of BCB+ oocytes from MF were superior to those from VSF and SF, blastocysts were successfully obtained from BCB+ oocytes even derived from VSF. The mean numbers of both total and viable cumulus cells surrounding an oocyte were significantly affected not only by the origin of the OCCs, but also by the BCB status of the oocytes (largest in MF-derived OCCs containing BCB+ oocytes). Although the outer and inner diameters of zona pellucida were affected by the origin of OCCs and the BCB status of oocytes (largest in MF-derived oocytes), the ooplasmic diameter of BCB+ oocytes did not differ among those derived from VSF, SF, and MF. Regardless of the BCB status, the transcriptional levels of G6PD and TKT in cumulus cells decreased during follicular development from VSF to MF, whereas the RPIA mRNA level in cumulus cells of MF-derived BCB+ OCCs was lower than in the others. These results underscore the utility of BCB staining for selecting MF-, SF-, and even VSF-derived OCCs containing oocytes with relatively higher meiotic and developmental competences, as well as the importance of having a sufficient number of healthy cumulus cells expressing genes related to the pentose phosphate pathway at lower levels. en-copyright= kn-copyright= en-aut-name=VanPhong Ngoc en-aut-sei=Van en-aut-mei=Phong Ngoc kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=DoSon Quang en-aut-sei=Do en-aut-mei=Son Quang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FonsekaWanniarachchige Tharindu Lakshitha en-aut-sei=Fonseka en-aut-mei=Wanniarachchige Tharindu Lakshitha kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=WakaiTakuya en-aut-sei=Wakai en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FunahashiHiroaki en-aut-sei=Funahashi en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=3 en-affil=Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=4 en-affil=Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=5 en-affil=Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University kn-affil= END