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en-title=Improved sedimentary layer model including the accretionary prism in the fore-arc region of the Ryukyu arc, Japan
kn-title=“ì�¼�”“‡‚Ì‘OŒÊˆæ‚É‚¨‚¯‚é•t‰Á‘Ì‚ðŠÜ‚Þ‘Í�Ï‘w‚̃‚ƒfƒ‹‰»
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kn-abstract=�@We combine the recent seismic reflection profiles to construct a new seismic velocity model of the sedimentary layer incorporating the accretionary prism along the Ryukyu trench. In constructing the new model, we refer to the zoning (ZONE1 to ZONE4) identified by Okamura et al. (2017, Tectonophys.). The construction process consists of the following steps: First, we digitize either unconformities or VP=4 to 5 km/s lines as the seismic basement, whichever is more clearly identifiable. Second, the digitized thickness data of the sedimentary layer from the reflection profiles are geometrically modeled and interpolated to make the three-dimensional structure model. Finally, we supplement the external region of the constructed 3-D sedimentary model using the J-SHIS model provided by the NIED to complete the velocity structure model in the entire Ryukyu arc. The main features of our model are as follows: In ZONE1, off Ishigaki-jima island, the thick sedimentary layer extends about 50 km wide from the Ryukyu trench. In ZONE2, off Miyako-jima island, the thinner layer compared to the other zones is found near the trench, with a thin sedimentary terrace covering the area behind it. In ZONE3, off Okinawa-jima island, the sedimentary layer deepens as it approaches the trench. In ZONE4, off Tokara islands, the deepest layer among all zones is identified. We then conduct 3-D finite-difference simulations of seismic wave propagation using the new and the previous models to confirm the improvement of the new model. In the simulations, the effects of the accretionary prism along the Ryukyu trench on the seismic wave propagation are clearly identified.
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affil-num=1
en-affil=Okayama Gakuin University
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affil-num=2
en-affil=Formerly Department of Earth Sciences, Okayama University
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affil-num=3
en-affil=Department of Earth and Planetary Sciences, School of Science, Institute of Science Tokyo
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affil-num=4
en-affil=Department of Earth Sciences, Okayama University
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en-keyword=Sedimentary layer model
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END

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kn-aut-mei=“¿�¬
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“��‡‰ÈŠwŒ¤‹†‰È
en-keyword=PrEP (Pre-exposure Prophylaxis)
kn-keyword=PrEP (Pre-exposure Prophylaxis)
en-keyword=HIV Prevention
kn-keyword=HIV Prevention
en-keyword=Social Stigma
kn-keyword=Social Stigma
en-keyword=Policy Support
kn-keyword=Policy Support
en-keyword=Regional Disparities
kn-keyword=Regional Disparities
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=
article-no=
start-page=11
end-page=18
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=An examination of decision-making support at the end of life on relational autonomy theory
kn-title=ŠÖŒW“IŽ©—¥—�˜_‚ÉŠî‚¢‚½�I––Šú‚ÉŠÖ‚·‚éˆÓŽvŒˆ’èŽx‰‡‚ÌŒŸ“¢
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In contemporary end-of-life care, it is difficult for patients to make decisions without the influence of society, family, and other factors. In many cases, patients have the capacity to make the decisions; nevertheless, they have difficulty expressing their own will because of the influence of their relationships and environment. Patient concerns about the burden of care and also the social and economic impacts on family members often hinder their use of imagination and decision-making. Therefore, this study has examined how patients with decision-making capacities could achieve autonomy under the influence of their relationships with their surroundings. The method of decision-making support provided by nurses to patients was examined using relational autonomy theory. Relational autonomy theory attempts to reconceptualize autonomy through feminists who criticize individualist theories of autonomy.
en-copyright=
kn-copyright=

en-aut-name=SONOYAMASumiyo
en-aut-sei=SONOYAMA
en-aut-mei=Sumiyo
kn-aut-name=‰€ŽR�ƒ‘ã
kn-aut-sei=‰€ŽR
kn-aut-mei=�ƒ‘ã
aut-affil-num=1
ORCID=

affil-num=1
en-affil=The University of Shimane
kn-affil=“‡�ªŒ§—§‘åŠw
en-keyword=relational autonomy
kn-keyword=relational autonomy
en-keyword=decision-making
kn-keyword=decision-making
en-keyword=end of life care
kn-keyword=end of life care
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=
article-no=
start-page=1
end-page=9
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Corporate decision-making process for exploration time
kn-title=’m‚Ì’T�õŽžŠÔ‚ɂ‚¢‚Ä‚ÌŠé‹Æ‚̈ӎvŒˆ’èƒvƒ�ƒZƒX
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order for companies to innovate through business co-creation, it is necessary to explore a wide range of external knowledge and technologies. However, there is no clear answer as to how much time should be spent for exploration. Under these circumstances, companies must take into account constraints such as the amount of management resources that can be invested, and make decisions about the time to spend for exploration. The purpose of this paper is to clarify the process of how companies that have introduced corporate accelerator program recognize the relationship between the program period and the results of business co-creation, and how they make decisions about the program period. We conducted a case study of several companies that have introduced corporate accelerator program in Japan. In addition, this paper established a hypothesis about decision-making about the time for exploration from case studies.
en-copyright=
kn-copyright=

en-aut-name=SHIMIZUTakeshi
en-aut-sei=SHIMIZU
en-aut-mei=Takeshi
kn-aut-name=Žu�…•�Žj
kn-aut-sei=Žu�…
kn-aut-mei=•�Žj
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems Okayama University
kn-affil=�‘—§‘åŠw–@�l‰ªŽR‘åŠwŠw�pŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“��‡‰ÈŠwŒ¤‹†Šwˆæ
en-keyword=corporate accelerator program
kn-keyword=corporate accelerator program
en-keyword=co-creation
kn-keyword=co-creation
en-keyword=exploration
kn-keyword=exploration
en-keyword=Time Compression Diseconomies
kn-keyword=Time Compression Diseconomies
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=•\Ž†�E–ÚŽŸ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=6
article-no=
start-page=668
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Robustness of Machine Learning Predictions for Determining Whether Deep Inspiration Breath-Hold Is Required in Breast Cancer Radiation Therapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background/Objectives: Deep inspiration breath-hold (DIBH) is a commonly used technique to reduce the mean heart dose (MHD), which is critical for minimizing late cardiac side effects in breast cancer patients undergoing radiation therapy (RT). Although previous studies have explored the potential of machine learning (ML) to predict which patients might benefit from DIBH, none have rigorously assessed ML model performance across various MHD thresholds and parameter settings. This study aims to evaluate the robustness of ML models in predicting the need for DIBH across different clinical scenarios. Methods: Using data from 207 breast cancer patients treated with RT, we developed and tested ML models at three MHD cut-off values (240, 270, and 300 cGy), considering variations in the number of independent variables (three vs. six) and folds in the cross-validation (three, four, and five). Robustness was defined as achieving high F2 scores and low instability in predictive performance. Results: Our findings indicate that the decision tree (DT) model demonstrated consistently high robustness at 240 and 270 cGy, while the random forest model performed optimally at 300 cGy. At 240 cGy, a threshold critical to minimize late cardiac risks, the DT model exhibited stable predictive power, reducing the risk of overestimating DIBH necessity. Conclusions: These results suggest that the DT model, particularly at lower MHD thresholds, may be the most reliable for clinical applications. By providing a tool for targeted DIBH implementation, this model has the potential to enhance patient-specific treatment planning and improve clinical outcomes in RT.
en-copyright=
kn-copyright=

en-aut-name=Al-HammadWlla E.
en-aut-sei=Al-Hammad
en-aut-mei=Wlla E.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KurodaMasahiro
en-aut-sei=Kuroda
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Al JamalJamal, Ghaida
en-aut-sei=Al Jamal
en-aut-mei=Jamal, Ghaida
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FujikuraMamiko
en-aut-sei=Fujikura
en-aut-mei=Mamiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KamizakiRyo
en-aut-sei=Kamizaki
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KurodaKazuhiro
en-aut-sei=Kuroda
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YoshidaSuzuka
en-aut-sei=Yoshida
en-aut-mei=Suzuka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NakamuraYoshihide
en-aut-sei=Nakamura
en-aut-mei=Yoshihide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OitaMasataka
en-aut-sei=Oita
en-aut-mei=Masataka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TanabeYoshinori
en-aut-sei=Tanabe
en-aut-mei=Yoshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SugimotoKohei
en-aut-sei=Sugimoto
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=SugiantoIrfan
en-aut-sei=Sugianto
en-aut-mei=Irfan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=BarhamMajd
en-aut-sei=Barham
en-aut-mei=Majd
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=TekikiNouha
en-aut-sei=Tekiki
en-aut-mei=Nouha
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=HisatomiMiki
en-aut-sei=Hisatomi
en-aut-mei=Miki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=AsaumiJunichi
en-aut-sei=Asaumi
en-aut-mei=Junichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Oral Medicine and Oral Surgery, Faculty of Dentistry, Jordan University of Science and Technology
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Graduate School of Interdisciplinary Sciences and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=10
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=11
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Oral Radiology, Faculty of Dentistry, Hasanuddin University
kn-affil=

affil-num=13
en-affil=Department of Dentistry and Dental Surgery, College of Medicine and Health Sciences, An-Najah National University
kn-affil=

affil-num=14
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=15
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=16
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=breast cancer
kn-keyword=breast cancer
en-keyword=radiation therapy
kn-keyword=radiation therapy
en-keyword=heart dose
kn-keyword=heart dose
en-keyword=cut-off value
kn-keyword=cut-off value
en-keyword=machine learning
kn-keyword=machine learning
en-keyword=robustness
kn-keyword=robustness
en-keyword=instability
kn-keyword=instability
en-keyword=F2 score
kn-keyword=F2 score
en-keyword=deep inspiration breath-hold technique
kn-keyword=deep inspiration breath-hold technique
en-keyword=computed tomography
kn-keyword=computed tomography
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=6
article-no=
start-page=790
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250320
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Improving Diagnostic Performance for Head and Neck Tumors with Simple Diffusion Kurtosis Imaging and Machine Learning Bi-Parameter Analysis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background/Objectives: Mean kurtosis (MK) values in simple diffusion kurtosis imaging (SDI)-a type of diffusion kurtosis imaging (DKI)-have been reported to be useful in the diagnosis of head and neck malignancies, for which pre-processing with smoothing filters has been reported to improve the diagnostic accuracy. Multi-parameter analysis using DKI in combination with other image types has recently been reported to improve the diagnostic performance. The purpose of this study was to evaluate the usefulness of machine learning (ML)-based multi-parameter analysis using the MK and apparent diffusion coefficient (ADC) values-which can be acquired simultaneously through SDI-for the differential diagnosis of benign and malignant head and neck tumors, which is important for determining the treatment strategy, as well as examining the usefulness of filter pre-processing. Methods: A total of 32 pathologically diagnosed head and neck tumors were included in the study, and a Gaussian filter was used for image pre-processing. MK and ADC values were extracted from pixels within the tumor area and used as explanatory variables. Five ML algorithms were used to create models for the prediction of tumor status (benign or malignant), which were evaluated through ROC analysis. Results: Bi-parameter analysis with gradient boosting achieved the best diagnostic performance, with an AUC of 0.81. Conclusions: The usefulness of bi-parameter analysis with ML methods for the differential diagnosis of benign and malignant head and neck tumors using SDI data were demonstrated.
en-copyright=
kn-copyright=

en-aut-name=YoshidaSuzuka
en-aut-sei=Yoshida
en-aut-mei=Suzuka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KurodaMasahiro
en-aut-sei=Kuroda
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakamuraYoshihide
en-aut-sei=Nakamura
en-aut-mei=Yoshihide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FukumuraYuka
en-aut-sei=Fukumura
en-aut-mei=Yuka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakamitsuYuki
en-aut-sei=Nakamitsu
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=Al-HammadWlla E.
en-aut-sei=Al-Hammad
en-aut-mei=Wlla E.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KurodaKazuhiro
en-aut-sei=Kuroda
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ShimizuYudai
en-aut-sei=Shimizu
en-aut-mei=Yudai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TanabeYoshinori
en-aut-sei=Tanabe
en-aut-mei=Yoshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OitaMasataka
en-aut-sei=Oita
en-aut-mei=Masataka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SugiantoIrfan
en-aut-sei=Sugianto
en-aut-mei=Irfan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=BarhamMajd
en-aut-sei=Barham
en-aut-mei=Majd
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=TekikiNouha
en-aut-sei=Tekiki
en-aut-mei=Nouha
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=KamaruddinNurul N.
en-aut-sei=Kamaruddin
en-aut-mei=Nurul N.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=HisatomiMiki
en-aut-sei=Hisatomi
en-aut-mei=Miki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=YanagiYoshinobu
en-aut-sei=Yanagi
en-aut-mei=Yoshinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=AsaumiJunichi
en-aut-sei=Asaumi
en-aut-mei=Junichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Graduate School of Interdisciplinary Sciences and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Oral Radiology, Faculty of Dentistry, Hasanuddin University
kn-affil=

affil-num=12
en-affil=Department of Dentistry and Dental Surgery, College of Medicine and Health Sciences, An-Najah National University
kn-affil=

affil-num=13
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=14
en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=15
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=16
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=17
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=head and neck tumors
kn-keyword=head and neck tumors
en-keyword=mean kurtosis
kn-keyword=mean kurtosis
en-keyword=simple diffusion kurtosis imaging
kn-keyword=simple diffusion kurtosis imaging
en-keyword=magnetic resonance imaging
kn-keyword=magnetic resonance imaging
en-keyword=apparent diffusion coefficient value
kn-keyword=apparent diffusion coefficient value
en-keyword=diffusion kurtosis imaging
kn-keyword=diffusion kurtosis imaging
en-keyword=machine learning
kn-keyword=machine learning
en-keyword=bi-parameter analysis
kn-keyword=bi-parameter analysis
en-keyword=gradient boosting
kn-keyword=gradient boosting
en-keyword=differential diagnosis of benign and malignant
kn-keyword=differential diagnosis of benign and malignant
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=
article-no=
start-page=143
end-page=144
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202503
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Summary of Research Activities : Okayama Administrative Law Research Group
kn-title=‰ªŽR�s�­–@ŽÀ–±Œ¤‹†‰ï�@Œ¤‹†‰ï‹L˜^�i‘æ37‰ñ�`‘æ38‰ñ�j
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=
article-no=
start-page=113
end-page=120
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202503
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=In-house lawyers working in non-legal departments
kn-title=”ñ–@–±•”–å‚Å“­‚­ƒCƒ“ƒnƒEƒX�|“à•”ŠÄ�¸�AŠÄ�¸–ðƒXƒ^ƒbƒt‹Æ–±‚Ì–£—Í�|
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MinamiYuko
en-aut-sei=Minami
en-aut-mei=Yuko
kn-aut-name=“ì—TŽq
kn-aut-sei=“ì
kn-aut-mei=—TŽq
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=�Ï�…‰»Šw�H‹ÆŠ”Ž®‰ïŽÐ�@ŠÄ�¸Žº
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=
article-no=
start-page=81
end-page=95
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202503
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Automated Vehicle-Related Incidents and Private International Law
kn-title=Ž©“®‰^“]ŽÔ‚Æ�‘�Û�Ù”»ŠÇŠ�Œ �E�€‹’–@
en-subtitle=
kn-subtitle=
en-abstract=
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en-title=Technology Overview of Automated Driving System and Problems to Introduce Autonomous Vehicle
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en-title=Establishment and Strengthening of Legal Human Resource Development Systems And Returning Routes in Cooperation with Regional Organizations
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en-aut-name=SuzukiTakamoto
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en-aut-name=OkamuraNobuhiro
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en-aut-name=TakehisaAkinari
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en-title=Punishment of Government Officials in the Qin and Han Periods �\Focusing on the�gFei�h and�gMian�h �\
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en-aut-name=LIUCong
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affil-num=1
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cd-journal=joma
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en-title=Regional Response to Securing Transportation through Mutual Assistance �\A Case Study of Okayama Prefecture�\
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affil-num=1
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cd-journal=joma
no-vol=59
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start-page=45
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kn-subject=
en-title=Reconsideration of Vocabulary Difficulty Standards in "Easy Japanese": From the subdivision of polysemous words by J-CLID
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en-aut-name=LUJianhui
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affil-num=1
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cd-journal=joma
no-vol=59
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article-no=
start-page=1
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dt-pub-year=2025
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kn-subject=
en-title=Study on the Accessibility of Admissions Information: Comparison of universities in Japan, East and South-East Asia and English-speaking countries
kn-title=“üŠw�î•ñ‚ւ̃AƒNƒZƒX�«‚ÉŠÖ‚·‚錤‹† �\“ú–{�A“Œ�E“Œ“ìƒAƒWƒA�A‰pŒêŒ—‚Ì‘åŠw‚Æ‚Ì”äŠr‚©‚ç�\
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en-aut-name=INAMORITakao
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en-aut-mei=Takao
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kn-aut-mei=Šx‰›
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affil-num=1
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kn-affil=‰ªŽR‘åŠwƒOƒ��[ƒoƒ‹�l�Þˆç�¬‰@
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cd-journal=joma
no-vol=74
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no-issue=3-4
article-no=
start-page=312
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dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250324
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kn-subject=
en-title=CJEU Cases on the Montreal Convention 1999
kn-title=ƒ‚ƒ“ƒgƒŠƒI�[ƒ‹�ð–ñ‚ÉŠÖ‚·‚é CJEU ”»—á‚Ì�Љî
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kn-subtitle=
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kn-copyright=

en-aut-name=MasudaF. 
en-aut-sei=Masuda
en-aut-mei=F. 
kn-aut-name=‘�“cŽjŽq
kn-aut-sei=‘�“c
kn-aut-mei=ŽjŽq
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ
END

start-ver=1.4
cd-journal=joma
no-vol=85
cd-vols=
no-issue=6
article-no=
start-page=1082
end-page=1096
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dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250314
dt-online=
en-article=
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kn-subject=
en-title=
kn-title=Myeloid Cells Induce Infiltration and Activation of B Cells and CD4+ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Brain metastasis is a poor prognostic factor in patients with cancer. Despite showing efficacy in many extracranial tumors, immunotherapy with anti?PD-1 mAb or anti?CTLA4 mAb seems to be less effective against intracranial tumors. Promisingly, recent clinical studies have reported that combination therapy with anti?PD-1 and anti?CTLA4 mAbs has a potent antitumor effect on brain metastasis, highlighting the need to elucidate the detailed mechanisms controlling the intracranial tumor microenvironment (TME) to develop effective immunotherapeutic strategies. In this study, we analyzed the tumor-infiltrating lymphocytes in murine models of brain metastasis that responded to anti?CTLA4 and anti?PD-1 mAbs. Activated CD4+ T follicular helper (TFH) cells with high CTLA4 expression characteristically infiltrated the intracranial TME, which were activated by combination anti?CTLA4 and anti?PD-1 treatment. The loss of TFH cells suppressed the additive effect of CTLA4 blockade on anti?PD-1 mAb. B-cell?activating factor belonging to the TNF family (BAFF) and a proliferation-inducing ligand (APRIL) produced by abundant myeloid cells, particularly CD80hiCD206lo proinflammatory M1-like macrophages, in the intracranial TME induced B-cell and TFH-cell infiltration and activation. Furthermore, the intracranial TME of patients with non?small cell lung cancer featured TFH- and B-cell infiltration as tertiary lymphoid structures. Together, these findings provide insights into the immune cell cross-talk in the intracranial TME that facilitates an additive antitumor effect of CTLA4 blockade with anti?PD-1 treatment, supporting the potential of a combination immunotherapeutic strategy for brain metastases.<br>
Significance: B-cell and CD4+ T follicular helper cell activation via BAFF/APRIL from abundant myeloid cells in the intracranial tumor microenvironment enables a combinatorial effect of CTLA4 and PD-1 blockade in brain metastases.
en-copyright=
kn-copyright=

en-aut-name=NinomiyaToshifumi
en-aut-sei=Ninomiya
en-aut-mei=Toshifumi
kn-aut-name=
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kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KemmotsuNaoya
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en-aut-mei=Naoya
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aut-affil-num=2
ORCID=

en-aut-name=MukoharaFumiaki
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en-aut-mei=Fumiaki
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aut-affil-num=3
ORCID=

en-aut-name=MagariMasaki
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en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
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ORCID=

en-aut-name=MiyamotoAi
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en-aut-mei=Ai
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kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=UedaYouki
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en-aut-mei=Youki
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kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=IshinoTakamasa
en-aut-sei=Ishino
en-aut-mei=Takamasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NagasakiJoji
en-aut-sei=Nagasaki
en-aut-mei=Joji
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=FujiwaraTomohiro
en-aut-sei=Fujiwara
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=YamamotoHidetaka
en-aut-sei=Yamamoto
en-aut-mei=Hidetaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=HayashiHidetoshi
en-aut-sei=Hayashi
en-aut-mei=Hidetoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=TachibanaKota
en-aut-sei=Tachibana
en-aut-mei=Kota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=IshidaJoji
en-aut-sei=Ishida
en-aut-mei=Joji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=OtaniYoshihiro
en-aut-sei=Otani
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=TanakaShota
en-aut-sei=Tanaka
en-aut-mei=Shota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
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aut-affil-num=16
ORCID=

en-aut-name=OkamotoIsamu
en-aut-sei=Okamoto
en-aut-mei=Isamu
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=TogashiYosuke
en-aut-sei=Togashi
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

affil-num=1
en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Medical Protein Engineering, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Orthopaedic Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Pathology and Oncology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Medical Oncology, Kindai University Faculty of Medicine
kn-affil=

affil-num=12
en-affil=Department of Dermatology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=13
en-affil=Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=14
en-affil=Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=15
en-affil=Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=16
en-affil=Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Science, Okayama University
kn-affil=

affil-num=17
en-affil=Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University
kn-affil=

affil-num=18
en-affil=Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
END

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cd-journal=joma
no-vol=15
cd-vols=
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start-page=
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dt-received=
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dt-accepted=
dt-pub-year=2025
dt-pub=20250328
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kn-subject=
en-title=
kn-title=‰ªŽR‘åŠw‹³Žt‹³ˆçŠJ”­ƒZƒ“ƒ^�[‚ÌŠˆ“®�󋵂̊T—v
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=
article-no=
start-page=341
end-page=355
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250328
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Research Trends on Educational Needs and Support of Children with Cancer
kn-title=�¬Ž™‚ª‚ñŠ³Ž™‚ɑ΂·‚鋳ˆç“IŽx‰‡‚Æ‚»‚ÌŒ¤‹†“®Œü
en-subtitle=
kn-subtitle=
en-abstract=�@In this study, we summarized research trends related to the educational needs and support of children with cancer from the perspectives of �glearning,�h �gself-management,�h �ginterpersonal,�h �gpsychological,�h and �gcollaboration,�h. In terms of learning, the study showed that experiential learning and distance education are solutions to the problem of delayed learning due to prolonged absence from school and poor concentration during treatment. Next, in self-management, it is important to educate affected children so that they can fully understand the disease and treatment. In addition, in terms of interpersonal support, it is difficult for the affected patients to build relationships with friends, but providing opportunities for interaction is expected to contribute to the improvement of interpersonal relationships. In terms of psychological support, the anxiety associated with treatment is a major psychological burden for the affected children, and the understanding of their friends and the intervention of university student volunteers are effective in helping them achieve psychological stability. Finally, the lack of cooperation between medical institutions and schools was highlighted as a deficiency in the support system, which needs to be strengthened. In the future, these support measures should be empirically verified to establish a sustainable support system.
kn-abstract=�@–{Œ¤‹†‚Í�A�¬Ž™‚ª‚ñŠ³Ž™‚Ì‹³ˆç“IŽx‰‡‚ÉŠÖ‚·‚錤‹†‚Ì“®Œü‚𖾂炩‚É‚µ�A�¡Œã‚̉ۑè‚Æ‚»‚̉ðŒˆ�ô‚ð’ñ‹N‚·‚邱‚Æ‚ð–Ú“I‚Æ‚µ‚½�B�uŠw�K�v�A�uŽ©ŒÈŠÇ—��v�A�u‘Î�l�v�A�u�S—��v�A�u˜AŒg�v‚Ì5‚‚̎‹“_‚©‚番�Í‚ð�s‚Á‚½�BŠw�KŽx‰‡‚ɂ‚¢‚Ä�AŽ¡—Âɔº‚¤Šw�K‚Ì’x‚ê‚â�W’†—͂̒ቺ‚ɑ΂µ�AŒÂ•Ê‚Ì‹³ˆçŽx‰‡Œv‰æ‚â‘ÌŒ±“I‚ÈŠw�K�A‚¨‚æ‚щ“Šu‹³ˆç‚ÌŽÀŽ{‚ÉŠú‘Ò‚³‚ê‚Ä‚¢‚½�BŽ©ŒÈŠÇ—�Žx‰‡‚Å‚Í�AŠ³Ž™‚ªŽ©�g‚Ì•a�ó‚⎡—Âɂæ‚é•›�ì—p‚ð—�‰ð‚µ�AŽ©—§“I‚ÉŠÇ—�‚Å‚«‚é”\—Í‚ðˆç�¬‚·‚邱‚Æ‚ª‹�‚ß‚ç‚ê‚Ä‚¢‚½�B‘Î�lŽx‰‡‚ɂ‚¢‚Ä�AŠ³Ž™‚Ì’·Šú“ü‰@‚É‚æ‚è�A—F�lŠÖŒW‚Ì�\’z‚ª�¢“ï‚É‚È‚è�A“ü‰@’†‚â•œŠwŒã‚̃Rƒ~ƒ…ƒjƒP�[ƒVƒ‡ƒ“‚ÌŽx‰‡‚ª�d—v‚Å‚ ‚邱‚Æ‚ªŠm”F‚³‚ꂽ�B�S—�Žx‰‡‚É‚¨‚¢‚Ä‚Í�AŽüˆÍ‚Ö‚ÌŒø‰Ê“I‚È‚ª‚ñ‹³ˆç‚â‘åŠw�¶ƒ{ƒ‰ƒ“ƒeƒBƒA‚É‚æ‚éŽx‰‡‚ª�AŠ³Ž™‚Ì�S—�“IˆÀ’è‚𑣂·‚±‚Æ‚ªŽ¦‚³‚ꂽ�B�ÅŒã‚É�AŠw�Z‚ƈã—Ë@ŠÖ�A•ÛŒìŽÒ‚̘AŒg•s‘«‚ªŽw“E‚³‚ê‚Ä‚¨‚è�A˜AŒgƒc�[ƒ‹‚ÌŠJ”­‚ª‹�‚ß‚ç‚ê‚Ä‚¢‚é�B
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kn-aut-sei=‹g—˜
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affil-num=1
en-affil=Graduate School of Education Doctoral Programs, Hyogo University of Teacher Education
kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@˜A�‡Šw�Z‹³ˆçŠwŒ¤‹†‰È”ŽŽm‰Û’ö

affil-num=2
en-affil=Graduate School of Education, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@‹³ˆçŠwˆæ
en-keyword=�¬Ž™‚ª‚ñ (child hood cancer)
kn-keyword=�¬Ž™‚ª‚ñ (child hood cancer)
en-keyword=–��«Ž¾Š³ (chronic illness)
kn-keyword=–��«Ž¾Š³ (chronic illness)
en-keyword=‹³ˆç“Iƒj�[ƒY (educational needs)
kn-keyword=‹³ˆç“Iƒj�[ƒY (educational needs)
en-keyword=Œ¤‹†“®Œü (research trends)
kn-keyword=Œ¤‹†“®Œü (research trends)
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cd-journal=joma
no-vol=15
cd-vols=
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article-no=
start-page=147
end-page=161
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250328
dt-online=
en-article=
kn-article=
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kn-subject=
en-title=Teacher Response Processes to Behavioral Problems in Students with Mild Intellectual Disabilities: An Examination Based on Practices at High School Division of Special Needs School A
kn-title=Œy“x’m“I�áŠQ‚Ì‚ ‚é�¶“k‚Ì�s“®–â‘è‚Ö‚Ì‹³ˆõ‘Ήž‰ß’ö�@�\A ’m“I�áŠQ“Á•ÊŽx‰‡Šw�Z�‚“™•”‚Å‚ÌŽÀ‘HŒŸ“¢‚ð’Ê‚µ‚Ä�\
en-subtitle=
kn-subtitle=
en-abstract=The purpose of this study is to clarify the framework for teachers when addressing behavioral problems of students in the high school division of a special needs school for students with intellectual disabilities. The methodology involved conducting interviews with four experienced teachers from School A, a special needs school for students with intellectual disabilities, which had successfully navigated difficult periods due to challenges in student guidance. Qualitative analysis was conducted using the Modified Grounded Theory Approach (M-GTA). As a result, two core categories emerged: "Building relationships with individuals that foster a sense of security" and "Aiming for shared and unified approaches." Sixteen concepts were generated. When faced with behavioral problems, teachers focused on "Building relationships with individuals that foster a sense of security" as the axis for responding to students, while behind the scenes the teachers worked collectively toward "Aiming for shared and unified approaches." Finally, based on the framework clarified in this study, a hierarchical, comprehensive support system, including individualized support, was proposed.
kn-abstract=�@–{Œ¤‹†‚Ì–Ú“I‚Í�C’m“I�áŠQ“Á•ÊŽx‰‡Šw�Z�‚“™•”‚É�Ý�Ђ·‚é�¶“k‚Ì�s“®–â‘è‚É’…–Ú‚µ�CŠw�ZŒ»�ê‚Å‹³ˆõ‚ª“K�؂ɑΉž‚·‚é�ۂ̘g‘g‚݂𖾂炩‚É‚·‚邱‚Æ‚Å‚ ‚é�B‚»‚Ì•û–@‚Æ‚µ‚Ä�C�¶“kŽw“±�ã‚̉ۑè‚ð—�—R‚Æ‚·‚鋳ˆç�¢“ïŠú‚ð�æ‚è‰z‚¦‚½A ’m“I�áŠQ“Á•ÊŽx‰‡Šw�Z�‚“™•”‚É�Š‘®‚µ‚Ä‚¢‚½ŒoŒ±–L•x‚È‹³ˆõ4–¼‚É–Ê�Ú’²�¸‚ðŽÀŽ{‚µ�CM-GTA ‚ÌŽè–@‚ð‰‡—p‚µ‚½Ž¿“I•ª�Í‚ð�s‚Á‚½�B‚»‚ÌŒ‹‰Ê�C�yˆÀ�SŠ´‚ð�¶‚ތ‚Ƃ̊֌W‚­‚è�z‚Æ�y‘Ήž•û–@‚Ì‹¤—L‚Æ“�ˆê‰»‚ð–ÚŽw‚·�zŠÖŒW�«‚ªƒRƒA�EƒJƒeƒSƒŠ�[‚ƈʒu‚«�C16‚Ì�”ŠT”O‚ð�¶�¬‚µ‚½�B�s“®–â‘è‚É’¼–Ê‚µ‚½‹³ˆõ‚Í�C�¶“k‚ɑ΂µ‚Ä‚Í�yˆÀ�SŠ´‚ð�¶‚ތ‚Ƃ̊֌W‚­‚è�z‚ð‘Ήž‚ÌŽ²‚Æ‚µ�C‚»‚Ì”wŒã‚Å‚ÍŠw�Z‚Æ‚µ‚Ä�y‘Ήž•û–@‚Ì‹¤—L‚Æ“�ˆê‰»‚ð–ÚŽw‚·�z‚½‚ß‚Ì“®‚«‚ð‚µ‚Ä‚¢‚½�B�ÅŒã‚É�C–{Œ¤‹†‚Å–¾‚ç‚©‚Æ‚È‚Á‚½‘Ήž‚̘g‘g‚݂ɂ‚¢‚Ä�lŽ@‚µ‚½ŠÏ“_‚©‚ç�CŒÂ•Ê‚ÌŽžŠÔ‚ðŠÜ‚ÞŠK‘w�«‚Ì‚ ‚é•ïŠ‡“I‚ÈŽx‰‡ƒVƒXƒeƒ€‚ðˆê‚‚̒ñˆÄ‚Æ‚µ‚½�B
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en-aut-name=MIYAZAKIYoshio
en-aut-sei=MIYAZAKI
en-aut-mei=Yoshio
kn-aut-name=‹{ú±‘P˜Y
kn-aut-sei=‹{ú±
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ORCID=

affil-num=1
en-affil=Graduate School of Education (Professional Degree Course), Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@�¶

affil-num=2
en-affil=Faculty of Education, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@‹³ˆçŠwˆæ
en-keyword=�‚“™•” (High school division)
kn-keyword=�‚“™•” (High school division)
en-keyword=Œy“x’m“I�áŠQ (Mild intellectual disabilities)
kn-keyword=Œy“x’m“I�áŠQ (Mild intellectual disabilities)
en-keyword=”­’B�áŠQ (Developmental disorders)
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cd-journal=joma
no-vol=15
cd-vols=
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article-no=
start-page=59
end-page=73
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250328
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en-title=Effects of Career Years on the Coordination Behavior of Yogo Teachers
kn-title=—{Œì‹³—@‚̃R�[ƒfƒBƒl�[ƒVƒ‡ƒ“�s“®‚É‹y‚Ú‚·ƒLƒƒƒŠƒA”N�”‚̉e‹¿
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en-abstract=The purpose of this study was to clarify the factors influencing coordination behavior of Yogo teachers and the relationship between the occurrence process of the factors and career years. The subjects analyzed were 695 persons working in public elementary and junior high schools. The effect of years of career was seen in the improvement of scale scores of factors related to the stages of coordination behavior and motivation, as well as subscale scores of the factors. <br>
The relationship between the number of years of career and factors related to the generation process of coordination behavior suggested three characteristics. That is, (1) The establishment of a foundation for organizational support that starts from collaboration, due to the correlation between factors showing high subscale scores unaffected by the number of years of career, and (2) The correlation among factors of motivational factors whose subscale scores increase with the number of years of career, which leads to the promotion of individualized support efforts, and (3) Correlation between factors of leader recognition and individual support seen in the career category of 11 years or more, and which leads to the promotion of expansion to management of organizational support.
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en-affil=Research student, United Graduate School of Education, Hyogo University of Teacher Education
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affil-num=2
en-affil=Graduate School of Education, Okayama University
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en-keyword=—{Œì‹³—@ (Yogo teacher)
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en-keyword=ƒR�[ƒfƒBƒl�[ƒVƒ‡ƒ“�s“® (coordination behavior)
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en-keyword=ŽÚ“x“¾“_ (scale score)
kn-keyword=ŽÚ“x“¾“_ (scale score)
en-keyword=‰ºˆÊŽÚ“x“¾“_ (subscale score‚’)
kn-keyword=‰ºˆÊŽÚ“x“¾“_ (subscale score‚’)
en-keyword=�s“®‚Ì�¶‹Nƒvƒ�ƒZƒX (process of behavioral development)
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affil-num=1
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dt-pub-year=2025
dt-pub=20250331
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en-title=Annual report / Institute of Plant Science and Resources, Okayama University
kn-title=‰ªŽR‘åŠwŽ‘Œ¹�A•¨‰ÈŠwŒ¤‹†�Š•ñ��
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en-aut-name=Institute of Plant Science and Resources, Okayama University
en-aut-sei=Institute of Plant Science and Resources, Okayama University
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dt-pub-year=2025
dt-pub=20250314
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en-title=KIBITANGO : Development and Implementation of an Academic English Vocabulary Learning Program
kn-title=‚«‚Ñ‚½‚ñ‚² �\ƒAƒJƒfƒ~ƒbƒN‰p’PŒêŠw�Kƒvƒ�ƒOƒ‰ƒ€‚ÌŠJ”­‚ÆŽÀ‘H•ñ���\
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en-abstract=At Okayama University, we have developed and provided a self-study material called "Kibitango" to help students improve their academic English vocabulary. The project began in 2019, with a focus on collecting frequently used words from academic journals, resulting in a list of 1,500 words. Each word comes with explanations by project members and examples of how it is used in academic papers. The material has been available to students since the 2022 academic year. Registered students receive one word per day via email and learn through the Kibitango website. The number of users has steadily increased. Today, however, several challenges have emerged, including the need to update the word list and improve the delivery method and system.
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en-affil=Institute for Promotion of Education and Campus Life, Okayama University
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en-affil=Institute for Promotion of Education and Campus Life, Okayama University
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cd-journal=joma
no-vol=56
cd-vols=
no-issue=3
article-no=
start-page=57
end-page=64
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250321
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Memorandum on Cost of sales calculation method
kn-title=”„�㌴‰¿ŽZ’è•û–@‚ÉŠÖ‚·‚éŠo�‘
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kn-subtitle=
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en-aut-name=FukeHiroyuki
en-aut-sei=Fuke
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kn-aut-name=•�‰Æ�O�s
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kn-aut-mei=�O�s
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start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=9
article-no=
start-page=
end-page=
dt-received=
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dt-accepted=
dt-pub-year=2016
dt-pub=20160908
dt-online=
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en-subject=
kn-subject=
en-title=
kn-title=S-nitrosylation of laforin inhibits its phosphatase activity and is implicated in Lafora disease
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Recently, the relation between S-nitrosylation by nitric oxide (NO), which is over?produced under pathological conditions and neurodegenerative diseases, includingAlzheimer�fs and Parkinson�fs diseases, has become a focus of attention. Although mostcases of Parkinson�fs disease are known to be caused by mutations in the Parkin gene, arecent finding has indicated that S-nitrosylation of Parkin affects its enzymatic activityand leads to the Parkinsonian phenotype. Therefore, it is important to understand thefunction of S-nitrosylated proteins in the pathogenesis of neurodegenerative diseases.Lafora disease (LD, OMIM 254780) is a neurodegenerative disease characterized by theaccumulation of insoluble glucans called Lafora bodies (LBs). LD is caused by mutationsin genes that encode the glucan phosphatase, Laforin, or the E3 ubiquitin ligase, Malin.In this study, we hypothesized that LD may be caused by S-nitrosylation of Laforin,which is similar to the finding that Parkinson�fs disease is caused by S-nitrosylation ofParkin. To test this hypothesis, we first determined whether Laforin was S-nitrosylatedusing a biotin switch assay, and compared the three main functions of unmodified andS-nitrosylated Laforin, namely glucan- and Malin-binding activity and phosphataseactivity. Furthermore, we examined whether the numbers of LBs were changed byNO in the cells expressing wild-type Laforin. Here, we report for the first time thatS-nitrosylation of Laforin inhibited its phosphatase activity and that LB formation wasincreased by an NO donor. Our results suggest a possible hypothesis for LD pathogenesis; that is, the decrease in phosphatase activity of Laforin by S-nitrosylation leads toincreased LB formation. Therefore, LD may be caused not only by mutations in theLaforin or Malin genes, but also by the S-nitrosylation of Laforin.

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en-aut-mei=Rikako
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en-aut-name=HonjoYasuko
en-aut-sei=Honjo
en-aut-mei=Yasuko
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en-aut-name=ImajoRisa
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en-aut-name=SatohAyano
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affil-num=1
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affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University; Research Institute for Radiation Biology and Medicine, Hiroshima University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University; Research Institute for Radiation Biology and Medicine, Hiroshima University
kn-affil=

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University; Research Institute for Radiation Biology and Medicine, Hiroshima University
kn-affil=
en-keyword=S-Nitrosylation Of Laforin
kn-keyword=S-Nitrosylation Of Laforin
en-keyword=Post-Translational Modification 
kn-keyword=Post-Translational Modification 
en-keyword=Nitrosylation
kn-keyword=Nitrosylation
en-keyword=Phosphatase
kn-keyword=Phosphatase
en-keyword=Glucan-Binding
kn-keyword=Glucan-Binding
END

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cd-journal=joma
no-vol=188
cd-vols=
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article-no=
start-page=123
end-page=127
dt-received=
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dt-accepted=
dt-pub-year=2025
dt-pub=20250228
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en-title=A Review of Research on Digital Media Usage in Japanese Infancy
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en-affil=Faculty of Education, Okayama University
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en-title=Research Trends in Children�fs Music Education and Behavior
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en-title=Classical Japanese Instrument Music: Connecting Local Communities and the Global World (2) ?Developing �eIntercultural Competence�f in Next Generation Cultural Exchange ?
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en-aut-name=BEPPUYuko
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en-aut-name=HIGUCHIAki
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en-aut-name=NAKAMURAAi
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en-aut-name=MIYOSHIKeiko
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en-aut-name=TOSAChihiro
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en-aut-name=HANAKUSAYoko
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en-aut-name=TAKESHITANoriko
en-aut-sei=TAKESHITA
en-aut-mei=Noriko
kn-aut-name=’|‰º‘¥Žq
kn-aut-sei=’|‰º
kn-aut-mei=‘¥Žq
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Faculty of Education, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@‹³ˆçŠwˆæ

affil-num=2
en-affil=Faculty of Education, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@‹³ˆçŠwˆæ

affil-num=3
en-affil=Doctoral Student at the Joint Graduate School in Science of School Education Hyogo University of Teacher Education (Okayama University)
kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@˜A�‡Šw�Z‹³ˆçŠwŒ¤‹†‰È”ŽŽm‰Û’ö�i‰ªŽR‘åŠw�Š‘®�j

affil-num=4
en-affil=Koto Player
kn-affil=ⵋȉ‰‘t‰Æ

affil-num=5
en-affil=Department of Early Childhood Education and Care, Kurashiki City College
kn-affil=‘q•~’ZŠú‘åŠw•ÛˆçŠw‰È

affil-num=6
en-affil=Okayama Prefectural School for the Deaf
kn-affil=‰ªŽRŒ§—§‰ªŽR˜WŠw�Z

affil-num=7
en-affil=Doctoral Student at the Joint Graduate School in Science of School Education Hyogo University of Teacher Education (Okayama University)
kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@˜A�‡Šw�Z‹³ˆçŠwŒ¤‹†‰È”ŽŽm‰Û’ö�i‰ªŽR‘åŠw�Š‘®�j

affil-num=8
en-affil=Master�fs Student at the Graduate School of Education in Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È�CŽm‰Û’ö

affil-num=9
en-affil=Master�fs Student at the Graduate School of Education in Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È�CŽm‰Û’ö

affil-num=10
en-affil=Research Student at the Joint Graduate School in Science of School Education Hyogo University of Teacher Education (Okayama University)
kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@˜A�‡Šw�Z‹³ˆçŠwŒ¤‹†‰ÈŒ¤‹†�¶�i‰ªŽR‘åŠw�Š‘®�j

affil-num=11
en-affil=Biwako-Gakuin University
kn-affil=‚т킱Šw‰@‘åŠw
en-keyword=˜aŠyŠí‰¹Šy
kn-keyword=˜aŠyŠí‰¹Šy
en-keyword=ˆÙ•¶‰»ŠÔ”\—Í
kn-keyword=ˆÙ•¶‰»ŠÔ”\—Í
en-keyword=ƒOƒ��[ƒoƒ‹
kn-keyword=ƒOƒ��[ƒoƒ‹
en-keyword=ŽŸ�¢‘ãˆç�¬
kn-keyword=ŽŸ�¢‘ãˆç�¬
en-keyword=Ž¿–⎆’²�¸
kn-keyword=Ž¿–⎆’²�¸
END

start-ver=1.4
cd-journal=joma
no-vol=197
cd-vols=
no-issue=
article-no=
start-page=115301
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202503
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Fraglide-1 from traditional Chinese aromatic vinegar: A natural AhR antagonist for atopic dermatitis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Traditional Chinese Zhenjiang aromatic vinegar (Kozu) contains Fraglide-1 (FG1), a bioactive lactone with demonstrated peroxisome proliferator-activated receptor gamma (PPARƒÁ) agonist and antioxidant activities. This study explored FG1's novel ability to antagonize the aryl hydrocarbon receptor (AhR) signaling pathway, which regulates artemin expression and contributes to itching and inflammation in atopic dermatitis. Through molecular docking simulations and cell-based assays in human keratinocytes, we demonstrated FG1's potent antagonistic activity against AhR signaling. FG1 effectively suppressed FICZ-induced inflammatory responses, including artemin expression, with potency (half maximal inhibitory concentration, IC50 = 5.1 ƒÊM) comparable to the synthetic antagonist StemRegenin 1 (SR1) while demonstrating a superior safety profile (median lethal concentration, LC50 > 100 ƒÊM vs. 27.5 ƒÊM for SR1). These findings expand our understanding of bioactive compounds from traditional fermented foods and their regulatory effects on AhR signaling, providing a foundation for future studies on FG1's role in modulating skin inflammation.
en-copyright=
kn-copyright=

en-aut-name=KatoKosuke
en-aut-sei=Kato
en-aut-mei=Kosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AkamatsuMiki
en-aut-sei=Akamatsu
en-aut-mei=Miki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KakimaruSaya
en-aut-sei=Kakimaru
en-aut-mei=Saya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KoreishiMayuko
en-aut-sei=Koreishi
en-aut-mei=Mayuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakagiMasahiro
en-aut-sei=Takagi
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MiyashitaMasahiro
en-aut-sei=Miyashita
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NakamuraYoshimasa
en-aut-sei=Nakamura
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SatohAyano
en-aut-sei=Satoh
en-aut-mei=Ayano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TsujinoYoshio
en-aut-sei=Tsujino
en-aut-mei=Yoshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=School of Materials Science, Japan Advanced Institute of Science and Technology
kn-affil=

affil-num=6
en-affil=Graduate School of Agriculture, Kyoto University
kn-affil=

affil-num=7
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=8
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=9
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=10
en-affil=Graduate School of Science, Technology and Innovation, Kobe University
kn-affil=
en-keyword=AhR
kn-keyword=AhR
en-keyword=Xenobiotic responsive element
kn-keyword=Xenobiotic responsive element
en-keyword=StemRegenin 1
kn-keyword=StemRegenin 1
en-keyword=ARNT
kn-keyword=ARNT
en-keyword=Atopic dermatitis
kn-keyword=Atopic dermatitis
en-keyword=Artemin
kn-keyword=Artemin
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=3
article-no=
start-page=1007
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250124
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=LRP4 and Agrin Are Modulated by Cartilage Degeneration and Involved in ƒÀ-Catenin Signaling in Human Articular Chondrocytes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We investigated the roles of low-density lipoprotein receptor-related protein (LRP) 4 and its ligand Agrin in the pathophysiology of cartilage degeneration. Immunohistochemical analysis of human normal articular cartilage and cartilage tissues from patients with osteoarthritis (OA) obtained during surgery of the knee joint showed marked LRP4 expression in the early stages of OA, which then decreased with cartilage degeneration, whereas Agrin was consistently increased with cartilage degeneration. In normal human articular chondrocytes (NHACs), mild cyclic tensile strain (CTS) (0.5 Hz, 5% elongation, 2 h) increased the expression of LRP4 and aggrecan (ACAN), while intense CTS (0.5 Hz, 10% elongation, 6 h) increased the expression of Agrin without affecting LRP4 expression. Treatment with recombinant human (rh) Agrin downregulated the mRNA expression of LRP4 and ACAN, but upregulated the expression of LRP5/6, SRY-box transcription factor 9 (SOX9), Runt-related transcription factor 2 (RUNX2), and a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4). Immunocytochemistry and Western blot analysis showed that rhAgrin treatment upregulated the expression of ƒÀ-catenin and SOX9. Agrin knockdown by siAGRN transfection partially reduced the nuclear protein expression of ƒÀ-catenin, which was increased with intense CTS. LRP4 knockdown by siLRP4 transfection increased the expression of LRP5/6, SOX9, RUNX2, ADAMTS-4, and Agrin. These results suggested that intense CTS increases the expression of Agrin, which might interfere with the role of LRP4 in the inhibition of LRP5/6 and their downstream ƒÀ-catenin signaling, leading to cartilage degeneration.
en-copyright=
kn-copyright=

en-aut-name=NaniwaShuichi
en-aut-sei=Naniwa
en-aut-mei=Shuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NishidaKeiichiro
en-aut-sei=Nishida
en-aut-mei=Keiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YoshidaAki
en-aut-sei=Yoshida
en-aut-mei=Aki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NasuYoshihisa
en-aut-sei=Nasu
en-aut-mei=Yoshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakaharaRyuichi
en-aut-sei=Nakahara
en-aut-mei=Ryuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OhtsukiTakashi
en-aut-sei=Ohtsuki
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HottaYoshifumi
en-aut-sei=Hotta
en-aut-mei=Yoshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ShimizuNoriyuki
en-aut-sei=Shimizu
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=IchikawaChinatsu
en-aut-sei=Ichikawa
en-aut-mei=Chinatsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=LinDeting
en-aut-sei=Lin
en-aut-mei=Deting
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OtsukaNoriaki
en-aut-sei=Otsuka
en-aut-mei=Noriaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Section of Medicine, Division of Medicine, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University
kn-affil=

affil-num=2
en-affil=Locomotive Pain Center, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Section of Medicine, Division of Medicine, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University
kn-affil=

affil-num=4
en-affil=Locomotive Pain Center, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Locomotive Pain Center, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Sayo Central Hospital
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Section of Medicine, Division of Medicine, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Orthopaedic Surgery, Section of Medicine, Division of Medicine, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Orthopaedic Surgery, Section of Medicine, Division of Medicine, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Orthopaedic Surgery, Section of Medicine, Division of Medicine, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Orthopaedic Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=osteoarthritis
kn-keyword=osteoarthritis
en-keyword=chondrocyte
kn-keyword=chondrocyte
en-keyword=mechanical stress
kn-keyword=mechanical stress
en-keyword=LRP4
kn-keyword=LRP4
en-keyword=Agrin
kn-keyword=Agrin
en-keyword=ƒÀ-catenin
kn-keyword=ƒÀ-catenin
en-keyword=SOX9
kn-keyword=SOX9
END

start-ver=1.4
cd-journal=joma
no-vol=114
cd-vols=
no-issue=
article-no=
start-page=1
end-page=10
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of dark respiration on dry matter production of various crop species
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=�@Eleven crops were cultivated: maize, sunflower, soybean, groundnuts, sesame, kenaf, barley, wheat, rice, potato, and sweet potato. The crop growth rate (CGR) and specific dark-respiration rate (Rs) were measured, and growth efficiency GE =CGR/(CGR+R) (R, respiratory loss) was calculated. In each crop, whole-plant Rs reached a maximum in the earlier stages of growth, declined rapidly until the early reproductive growth, and remained almost constant during the ripening period. The Rs of leaves was higher than that of stems during the reproductive growth period, except for maize and potato. The Rs of storage organs was highest in the earlier stages, followed by a rapid decline to similar or lower values than those of leaves and stems during the ripening period. The GE in whole plant was higher than 60% in wheat, maize, barley, sunflower, rice, kenaf, sesame, but lower in soybean, sweet potato and groundnuts, and lowest in potato, which was affected by the higher respiratory loss. The GE in whole plant during the reproductive growth period was significantly lower, which we attributed to increased maintenance costs due to the increase of non-assimilative organs, and decrease in the dry weight of vegetative organs. A positive correlation was observed between the carbohydrate content of storage organs and GE, indicating that a crop with higher carbohydrate content in storage organs tended to have a higher GE. Crops with higher protein and crude fat content in storage organs tended to have lower GE. The GE over the growing season was low for kenaf, a fiber crop which contains high molecular weight compounds such as lignin and cellulose, and lower for sesame, groundnuts, and soybean, which contain high oil and protein and have high respiration costs for the synthesis of storage materials, suggesting that these higher respiration costs are related to lower dry matter production and hence lower yields.
en-copyright=
kn-copyright=

en-aut-name=SaitohKuniyuki
en-aut-sei=Saitoh
en-aut-mei=Kuniyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MurakamiTomohiro
en-aut-sei=Murakami
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakamuraYumi
en-aut-sei=Nakamura
en-aut-mei=Yumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NishiboriMisa
en-aut-sei=Nishibori
en-aut-mei=Misa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakagoshiYuki
en-aut-sei=Takagoshi
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HiraiYoshihiko
en-aut-sei=Hirai
en-aut-mei=Yoshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=School of Agriculture, Okayama University
kn-affil=

affil-num=4
en-affil=School of Agriculture, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=
en-keyword=Cereal crops
kn-keyword=Cereal crops
en-keyword=Oil crops
kn-keyword=Oil crops
en-keyword=Crop growth rate
kn-keyword=Crop growth rate
en-keyword=Dark-respiration
kn-keyword=Dark-respiration
en-keyword=Growth efficiency
kn-keyword=Growth efficiency
en-keyword=Leguminous crops
kn-keyword=Leguminous crops
en-keyword=Nutrients composition
kn-keyword=Nutrients composition
en-keyword=Respiratory loss
kn-keyword=Respiratory loss
en-keyword=Root and tuber crops
kn-keyword=Root and tuber crops
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=1
article-no=
start-page=63
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250113
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Impact of Task Context on Pleasantness and Softness Estimations: A Study Based on Three Touch Strategies
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study investigated the two distinct perceptions (pleasantness and softness) of deformable stimuli with different degrees of compliance under conditions with and without a contextual task. Three tactile strategies-grasping, pinching, and pressing-were used to perceive the stimuli. In Experiment 1 (without a contextual task), participants estimated the perceived intensity of softness or pleasantness for each stimulus. In Experiment 2 (with a contextual task), the participants sequentially perceived two stimuli with different compliance levels and indicated which stimulus they perceived as softer and pleasant. The results showed that the psychophysical relationship between compliance and perceived softness was consistent across all tactile strategies in both experiments, with softness estimates increasing as compliance increased. However, the relationship between compliance and pleasantness differed between the two experiments. In Experiment 1, pleasantness estimates increased monotonically with increased compliance. However, in Experiment 2, across all tactile strategies, pleasantness began to decrease within the compliance range of 0.25-2.0 cm2/N, exhibiting an inverted U-shaped trend. These findings indicate that the relationship between compliance and pleasantness is task-dependent, particularly demonstrating significantly different trends when a contextual task is introduced. In contrast, the relationship between compliance and softness remained consistently monotonic.
en-copyright=
kn-copyright=

en-aut-name=GaoBinyue
en-aut-sei=Gao
en-aut-mei=Binyue
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YuYinghua
en-aut-sei=Yu
en-aut-mei=Yinghua
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=EjimaYoshimichi
en-aut-sei=Ejima
en-aut-mei=Yoshimichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=WuJinglong
en-aut-sei=Wu
en-aut-mei=Jinglong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YangJiajia
en-aut-sei=Yang
en-aut-mei=Jiajia
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=pleasantness
kn-keyword=pleasantness
en-keyword=softness
kn-keyword=softness
en-keyword=touch strategy
kn-keyword=touch strategy
en-keyword=task context
kn-keyword=task context
en-keyword=psychophysics
kn-keyword=psychophysics
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=1
article-no=
start-page=46
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250113
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Mapping Surface Potential in DNA Aptamer-Neurochemical and Membrane-Ion Interactions on the SOS Substrate Using Terahertz Microscopy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this study, we utilized a terahertz chemical microscope (TCM) to map surface potential changes induced by molecular interactions on silicon-on-sapphire (SOS) substrates. By functionalizing the SOS substrate with DNA aptamers and an ion-selective membrane, we successfully detected and visualized aptamer-neurochemical complexes through the terahertz amplitude. Additionally, comparative studies of DNA aptamers in PBS buffer and artificial cerebrospinal fluid (aCSF) were performed by computational structure modeling and terahertz measurements. Beyond neurochemicals, we also investigated calcium ions, measuring their concentrations in PDMS-fabricated micro-wells using minimal sample volumes. Our results highlight the capability of TCM as a powerful, label-free, and sensitive platform for the probing and mapping of surface potential arising from molecular interactions, with broad implications for biomedical diagnostics and research.
en-copyright=
kn-copyright=

en-aut-name=MoritaKosei
en-aut-sei=Morita
en-aut-mei=Kosei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MitsudaYuta
en-aut-sei=Mitsuda
en-aut-mei=Yuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YoshidaSota
en-aut-sei=Yoshida
en-aut-mei=Sota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KiwaToshihiko
en-aut-sei=Kiwa
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WangJin
en-aut-sei=Wang
en-aut-mei=Jin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=terahertz chemical microscope
kn-keyword=terahertz chemical microscope
en-keyword=surface potential
kn-keyword=surface potential
en-keyword=DNA aptamer-neurochemical complexes
kn-keyword=DNA aptamer-neurochemical complexes
en-keyword=membrane-ion interactions
kn-keyword=membrane-ion interactions
en-keyword=SOS substrate
kn-keyword=SOS substrate
en-keyword=artificial cerebrospinal fluid
kn-keyword=artificial cerebrospinal fluid
END

start-ver=1.4
cd-journal=joma
no-vol=53
cd-vols=
no-issue=1
article-no=
start-page=65
end-page=69
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202501
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effectiveness of sensing gloves?applied virtual reality education system on hand hygiene practice: A randomized controlled trial
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: We developed a virtual reality (VR) education system and evaluated its clinical utility for promoting hand hygiene practices.<br>
Methods: This prospective, 2-week, randomized controlled study conducted at Okayama University Hospital, Japan, from November 2023 to January 2024, involved 22 participants (18 medical students and 4 residents). A fully immersive 360�‹ VR system (VIVE Pro Eye) using a head-mounted display and sensing gloves was used to develop 3 health care tasks in a virtual patient room?Environmental Cleaning, Gauze Exchange, and Urine Collection. After monitoring all participants' baseline usage data of portable hand-rubbing alcohol in the first week, we randomly assigned them into 1:1 groups (VR training and video lecture groups). The primary outcome was differences in hand-rubbed alcohol use before and after intervention.<br>
Results: Before the intervention, alcohol use did not significantly differ between both groups. After the intervention, a significant increase in alcohol use was observed in the VR training group (median: 8.2 g vs 16.2 g; P = .019) but not in the video lecture group.<br>
Conclusions: Our immersive 360�‹ VR education system enhanced hand hygiene practices. Infection prevention and control practitioners and digital technology experts must collaborate to advance the development of superior educational devices and content.
en-copyright=
kn-copyright=

en-aut-name=IzumiMahiro
en-aut-sei=Izumi
en-aut-mei=Mahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HagiyaHideharu
en-aut-sei=Hagiya
en-aut-mei=Hideharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OtsukaYuki
en-aut-sei=Otsuka
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SoejimaYoshiaki
en-aut-sei=Soejima
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FukushimaShinnosuke
en-aut-sei=Fukushima
en-aut-mei=Shinnosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ShibataMitsunobu
en-aut-sei=Shibata
en-aut-mei=Mitsunobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HirotaSatoshi
en-aut-sei=Hirota
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KoyamaToshihiro
en-aut-sei=Koyama
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=GofukuAkio
en-aut-sei=Gofuku
en-aut-mei=Akio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Quality Assurance Center, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Infectious Diseases, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Infectious Diseases, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Quality Assurance Center, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=7
en-affil=Quality Assurance Center, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Health Data Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Quality Assurance Center, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=Infection prevention and control
kn-keyword=Infection prevention and control
en-keyword=Medical-engineering collaboration
kn-keyword=Medical-engineering collaboration
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=
article-no=
start-page=195
end-page=212
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On the Usage Patterns of 'de' in Conversations by Japanese Language Learners: An Analysis Based on the "International Corpus of Japanese as a Second Language�iI-JAS�j"
kn-title=�u‘½Œ¾Œê•êŒê‚Ì“ú–{ŒêŠw�KŽÒ‰¡’fƒR�[ƒpƒX�iI ? JAS�j�v‚©‚猩‚½“ú–{ŒêŠw�KŽÒ‚̉ï˜b‚É‚¨‚¯‚é�u‚Å�v‚ÌŽg—pŽÀ‘Ԃɂ‚¢‚Ä�\“ú–{Œê•êŒê˜bŽÒ‚Æ‚Ì”äŠr‚ð’Ê‚¶‚Ä�\
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=LIUYang
en-aut-sei=LIU
en-aut-mei=Yang
kn-aut-name=—«—m
kn-aut-sei=—«
kn-aut-mei=—m
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=
article-no=
start-page=175
end-page=193
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Testing the Effectiveness of Food Loss Reduction Campaigns. �\A Study from the Analysis of Two Types of Consumer Behaviour Based on Longitudinal Data �\
kn-title=�H•iƒ�ƒX�팸ƒLƒƒƒ“ƒy�[ƒ“‚ÌŒø‰ÊŒŸ�Ø�\�c’fƒf�[ƒ^‚É‚æ‚é‚QŽí—Þ‚Ì�Á”ïŽÒ�s“®•ª�Í‚©‚ç‚Ì�lŽ@�\
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KANDAMasashi
en-aut-sei=KANDA
en-aut-mei=Masashi
kn-aut-name=�_“c›’Žu
kn-aut-sei=�_“c
kn-aut-mei=›’Žu
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=
article-no=
start-page=33
end-page=52
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Development of the Multipurpose Japanese Vocabulary Database J-CLID:C4
kn-title=“��‡Œ^“ú–{ŒêŒêœbƒf�[ƒ^ƒx�[ƒXJ-CLID:C4‚Ì�\’z
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=LUJianhui
en-aut-sei=LU
en-aut-mei=Jianhui
kn-aut-name=˜CŒš‹P
kn-aut-sei=˜C
kn-aut-mei=Œš‹P
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=
article-no=
start-page=1
end-page=13
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=(Translation) Katrina Jaworski: The Gender of Suicide, Part 1
kn-title=ƒJƒgƒŠ�[ƒi�EƒWƒƒƒ{ƒ‹ƒXƒL�FŽ©ŽE‚ƃWƒFƒ“ƒ_�[‚̎ЉïŠw�\�\•¶Šw•”ƒvƒ�ƒWƒFƒNƒg�iƒWƒFƒ“ƒ_�[‚Ì‘½‘w�«‚ÉŠÖ‚·‚é—̈扡’f“IŒ¤‹†3�j‚Ì�u‰‰‹L˜^�i‘O”¼�j�\�\
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SAITOKeisuke
en-aut-sei=SAITO
en-aut-mei=Keisuke
kn-aut-name=âV“¡Œ\‰î
kn-aut-sei=âV“¡
kn-aut-mei=Œ\‰î
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=49
end-page=73
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250115
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Mechanism in Leibniz from a Medical-Philosophical Point of View
kn-title=ƒ‰ƒCƒvƒjƒbƒc‚Ì‹@ŠB˜_�\ˆãŠw“NŠw“IŠÏ“_‚©‚ç
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MATSUDATsuyoshi
en-aut-sei=MATSUDA
en-aut-mei=Tsuyoshi
kn-aut-name=�¼“c‹B
kn-aut-sei=�¼“c
kn-aut-mei=‹B
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=23
end-page=32
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250115
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Ethical Life as �gLiving Good�h: In Comparison with the Thought of the Young Hegel
kn-title=�u�¶‚¯‚é‘P�v‚Æ‚µ‚Ä‚Ì�l—Ï�\�‰Šúƒw�[ƒQƒ‹‚ÌŽ‹“_‚©‚ç�\
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TAKESHIMAAyumi
en-aut-sei=TAKESHIMA
en-aut-mei=Ayumi
kn-aut-name=’|“‡‚ ‚ä‚Ý
kn-aut-sei=’|“‡
kn-aut-mei=‚ ‚ä‚Ý
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È
END

start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=
article-no=
start-page=106672
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202502
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Resveratrol, a food-derived polyphenol, promotes Melanosomal degradation in skin fibroblasts through coordinated activation of autophagy, lysosomal, and antioxidant pathways
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Resveratrol, a polyphenol found in grapes and peanuts, is known for diverse biological activities, yet its effects on dermal hyperpigmentation (so-called dark spots) remain unexplored. We investigated resveratrol's ability to enhance melanosomal degradation in human dermal fibroblasts. At concentrations of 25-50 mu M, resveratrol increased autophagy as measured by microtubule-associated protein 1A/1B-light chain 3 (LC3)-II/LC3-I ratio and enhanced lysosomal activity as assessed by a lysosomal activity reporter system. RNA sequencing revealed upregulation of lysosomal and autophagy-related genes, including cathepsins. Furthermore, reporter assays showed resveratrol's activation of antioxidant response via nuclear factor erythroid 2-related factor 2 (NRF2)mediated, leading to upregulation of transcription factor EB/transcription factor E3 (TFEB/TFE3), master regulators of lysosomal function. In fibroblasts pre-loaded with melanosomes, resveratrol reduced melanosome content compared to control by day 3. The findings reveal the activation of interconnected autophagy, lysosomal, and antioxidant pathways by resveratrol, suggesting potential applications in functional foods targeting dermal hyperpigmentation.
en-copyright=
kn-copyright=

en-aut-name=OkamotoSaki
en-aut-sei=Okamoto
en-aut-mei=Saki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KakimaruSaya
en-aut-sei=Kakimaru
en-aut-mei=Saya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KoreishiMayuko
en-aut-sei=Koreishi
en-aut-mei=Mayuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SakamotoMika
en-aut-sei=Sakamoto
en-aut-mei=Mika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakamuraYoshimasa
en-aut-sei=Nakamura
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=AndoHideya
en-aut-sei=Ando
en-aut-mei=Hideya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TsujinoYoshio
en-aut-sei=Tsujino
en-aut-mei=Yoshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SatohAyano
en-aut-sei=Satoh
en-aut-mei=Ayano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=National Institute of Genetics, ROIS
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Applied Chemistry and Biotechnology, Okayama University of Science
kn-affil=

affil-num=7
en-affil=Graduate School of Science, Technology, and Innovation, Kobe University
kn-affil=

affil-num=8
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=Antioxidant
kn-keyword=Antioxidant
en-keyword=Lysosomes
kn-keyword=Lysosomes
en-keyword=Autophagy
kn-keyword=Autophagy
en-keyword=Resveratrol
kn-keyword=Resveratrol
en-keyword=Skin fibroblasts
kn-keyword=Skin fibroblasts
en-keyword=Bioactive compounds
kn-keyword=Bioactive compounds
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=1
article-no=
start-page=60
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250106
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Novel Drug Delivery Particles Can Provide Dual Effects on Cancer "Theranostics" in Boron Neutron Capture Therapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Boron (B) neutron capture therapy (BNCT) is a novel non-invasive targeted cancer therapy based on the nuclear capture reaction 10B (n, alpha) 7Li that enables the death of cancer cells without damaging neighboring normal cells. However, the development of clinically approved boron drugs remains challenging. We have previously reported on self-forming nanoparticles for drug delivery consisting of a biodegradable polymer, namely, �gAB-type�h Lactosome? nanoparticles (AB-Lac particles)- highly loaded with hydrophobic B compounds, namely o-Carborane (Carb) or 1,2-dihexyl-o-Carborane (diC6-Carb), and the latter (diC6-Carb) especially showed the �gmolecular glue�h effect. Here we present in vivo and ex vivo studies with human pancreatic cancer (AsPC-1) cells to find therapeutically optimal formulas and the appropriate treatment conditions for these particles. The biodistribution of the particles was assessed by the tumor/normal tissue ratio (T/N) in terms of tumor/muscle (T/M) and tumor/blood (T/B) ratios using near-infrared fluorescence (NIRF) imaging with indocyanine green (ICG). The in vivo and ex vivo accumulation of B delivered by the injected AB-Lac particles in tumor lesions reached a maximum by 12 h post-injection. Irradiation studies conducted both in vitro and in vivo showed that AB-Lac particles-loaded with either 10B-Carb or 10B-diC6-Carb significantly inhibited the growth of AsPC-1 cancer cells or strongly inhibited their growth, with the latter method being significantly more effective. Surprisingly, a similar in vitro and in vivo irradiation study showed that ICG-labeled AB-Lac particles alone, i.e., without any 10B compounds, also revealed a significant inhibition. Therefore, we expect that our ICG-labeled AB-Lac particles-loaded with 10B compound(s) may be a novel and promising candidate for providing not only NIRF imaging for a practical diagnosis but also the dual therapeutic effects of induced cancer cell death, i.e., �gtheranostics�h.
en-copyright=
kn-copyright=

en-aut-name=FithroniAbdul Basith
en-aut-sei=Fithroni
en-aut-mei=Abdul Basith
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=InoueHaruki
en-aut-sei=Inoue
en-aut-mei=Haruki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ZhouShengli
en-aut-sei=Zhou
en-aut-mei=Shengli
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HakimTaufik Fatwa Nur
en-aut-sei=Hakim
en-aut-mei=Taufik Fatwa Nur
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TadaTakashi
en-aut-sei=Tada
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SuzukiMinoru
en-aut-sei=Suzuki
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SakuraiYoshinori
en-aut-sei=Sakurai
en-aut-mei=Yoshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IshimotoManabu
en-aut-sei=Ishimoto
en-aut-mei=Manabu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YamadaNaoyuki
en-aut-sei=Yamada
en-aut-mei=Naoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=SauriasariRani
en-aut-sei=Sauriasari
en-aut-mei=Rani
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SauerweinWolfgang A. G.
en-aut-sei=Sauerwein
en-aut-mei=Wolfgang A. G.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=WatanabeKazunori
en-aut-sei=Watanabe
en-aut-mei=Kazunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=OhtsukiTakashi
en-aut-sei=Ohtsuki
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=MatsuuraEiji
en-aut-sei=Matsuura
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=6
en-affil=Institute for Integrated Radiation and Nuclear Science, Kyoto University
kn-affil=

affil-num=7
en-affil=Institute for Integrated Radiation and Nuclear Science, Kyoto University
kn-affil=

affil-num=8
en-affil=J-BEAM, Inc.
kn-affil=

affil-num=9
en-affil=Nihon Fukushi Fuiin Holding, Co., Ltd.
kn-affil=

affil-num=10
en-affil=Faculty of Pharmacy, Universitas Indonesia
kn-affil=

affil-num=11
en-affil=Deutsche Gesellschaft f?r Bor-Neutroneneinfangtherapie DGBNCT e.V., University Hospital Essen, Klinik f?r Strahlentherapie
kn-affil=

affil-num=12
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=13
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=14
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=boron neutron capture therapy (BNCT)
kn-keyword=boron neutron capture therapy (BNCT)
en-keyword=dual therapeutic effects
kn-keyword=dual therapeutic effects
en-keyword=Lactosome ?
kn-keyword=Lactosome ?
en-keyword=hydrophobic boron compound
kn-keyword=hydrophobic boron compound
en-keyword=neutron irradiation
kn-keyword=neutron irradiation
en-keyword=theranostics
kn-keyword=theranostics
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=12
article-no=
start-page=1258
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241215
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Impact of Selective Spatial Attention on Auditory-Tactile Integration: An Event-Related Potential Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Auditory-tactile integration is an important research area in multisensory integration. Especially in special environments (e.g., traffic noise and complex work environments), auditory-tactile integration is crucial for human response and decision making. We investigated the influence of attention on the temporal course and spatial distribution of auditory-tactile integration. Methods: Participants received auditory stimuli alone, tactile stimuli alone, and simultaneous auditory and tactile stimuli, which were randomly presented on the left or right side. For each block, participants attended to all stimuli on the designated side and detected uncommon target stimuli while ignoring all stimuli on the other side. Event-related potentials (ERPs) were recorded via 64 scalp electrodes. Integration was quantified by comparing the response to the combined stimulus to the sum of the responses to the auditory and tactile stimuli presented separately. Results: The results demonstrated that compared to the unattended condition, integration occurred earlier and involved more brain regions in the attended condition when the stimulus was presented in the left hemispace. The unattended condition involved a more extensive range of brain regions and occurred earlier than the attended condition when the stimulus was presented in the right hemispace. Conclusions: Attention can modulate auditory-tactile integration and show systematic differences between the left and right hemispaces. These findings contribute to the understanding of the mechanisms of auditory-tactile information processing in the human brain.
en-copyright=
kn-copyright=

en-aut-name=AnWeichao
en-aut-sei=An
en-aut-mei=Weichao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ZhangNan
en-aut-sei=Zhang
en-aut-mei=Nan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=LiShengnan
en-aut-sei=Li
en-aut-mei=Shengnan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YuYinghua
en-aut-sei=Yu
en-aut-mei=Yinghua
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WuJinglong
en-aut-sei=Wu
en-aut-mei=Jinglong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YangJiajia
en-aut-sei=Yang
en-aut-mei=Jiajia
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=auditory-tactile integration
kn-keyword=auditory-tactile integration
en-keyword=selective spatial attention
kn-keyword=selective spatial attention
en-keyword=event-related potential
kn-keyword=event-related potential
en-keyword=left-right hemispace differences
kn-keyword=left-right hemispace differences
en-keyword=spatiotemporal distribution
kn-keyword=spatiotemporal distribution
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=12
article-no=
start-page=1184
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241126
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Contributions of the Primary Sensorimotor Cortex and Posterior Parietal Cortex to Motor Learning and Transfer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Transferring learned manipulations to new manipulation tasks has enabled humans to realize thousands of dexterous object manipulations in daily life. Two-digit grasp and three-digit grasp manipulations require different fingertip forces, and our brain can switch grasp types to ensure good performance according to motor memory. We hypothesized that several brain areas contribute to the execution of the new type of motor according to the motor memory. However, the motor memory mechanisms during this transfer period are still unclear. In the present functional magnetic resonance imaging (fMRI) study, we aimed to investigate the cortical mechanisms involved in motor memory during the transfer phase of learned manipulation tasks. Methods: Using a custom-built T-shaped object with an adjustable weight distribution, the participants performed grasp and lift manipulation tasks under different conditions to simulate the learning and transfer phases. The learning phase consisted of four grasp-and-lift repetitions with one motor type, followed by a transfer phase with four repetitions involving different motors (adding or removing a digit). Results: By comparing brain activity in the learning and transfer phases, we identified three regions (the superior frontal gyrus, supramarginal gyrus, and postcentral gyrus) associated with motor memory during the transfer of learned manipulations. Conclusions: Our findings improve the understanding of the role of the posterior parietal cortex in motor memory, highlighting how sensory information from memory and real-time input is integrated to generate novel motor control signals that guide the precise reapplication of control strategies. Furthermore, we believe that these areas contribute to motor learning from motor memory and may serve as key regions of interest for investigating neurodegenerative diseases.
en-copyright=
kn-copyright=

en-aut-name=WangChenyu
en-aut-sei=Wang
en-aut-mei=Chenyu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YuYinghua
en-aut-sei=Yu
en-aut-mei=Yinghua
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YangJiajia
en-aut-sei=Yang
en-aut-mei=Jiajia
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=fMRI
kn-keyword=fMRI
en-keyword=motor learning and transfer
kn-keyword=motor learning and transfer
en-keyword=primary sensorimotor cortex
kn-keyword=primary sensorimotor cortex
en-keyword=posterior parietal cortex
kn-keyword=posterior parietal cortex
END

start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=3
article-no=
start-page=620
end-page=626
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=2023
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=All-in-one terahertz taste sensor: integrated electronic and bioelectronic tongues
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Taste sensors, also known as electronic tongues or bioelectronic tongues, are designed to evaluate food and beverages, as well as for medical diagnostics. These devices mimic the ability of the human tongue to detect and identify different tastes in liquid samples, such as sweet, sour, salty, bitter, and umami. In this study, a novel all-in-one terahertz taste sensor was proposed, which differs from traditional electrochemical approaches. This sensor utilizes terahertz technology for imaging and sensing chemical reactions on the terahertz semiconductor emitter surface. The surface can be functionalized with ion-sensitive membranes, proteins, DNA aptamers, and organic receptors, enabling the detection of various substances, such as solution pH, physiological ions, sugars, toxic chemicals, drugs, and explosives. Terahertz taste sensors offer several advantages, including being label-free, high sensitivity and selectivity, rapid response, minimal sample consumption, and the ability to detect non-charged chemical substances. By integrating multiple receptors or sensing materials on a single chip, the all-in-one terahertz taste sensor has significant potential for future taste substance detection, nutrition evaluation, metabolite and drug monitoring, and biomarker sensing.
en-copyright=
kn-copyright=

en-aut-name=WangJin
en-aut-sei=Wang
en-aut-mei=Jin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SakaiKenji
en-aut-sei=Sakai
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KiwaToshihiko
en-aut-sei=Kiwa
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=35
cd-vols=
no-issue=1
article-no=
start-page=65
end-page=73
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230220
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Development of Automatic Inspection Systems for WRS2020 Plant Disaster Prevention Challenge Using Image Processing
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this article, an approach used for the inspection tasks in the WRS2020 Plant Disaster Prevention Challenge is explained. The tasks were categorized into three categories: reading pressure gauges, inspecting rust on a tank, and inspecting cracks in a tank. For reading pressure gauges, the �gyou only look once�h algorithm was used to focus on a specific pressure gauge and check the pressure gauge range strings on the gauge using optical character recognition algorithm. Finally, a previously learned classifier was used to read the values shown in the gauge. For rust inspection, image processes were used to focus on a target plate that may be rusted for rust detection. In particular, it was necessary to report the rust area and distribution type. Thus, the pixel ratio and grouping of rust were used to count the rust. The approach for crack inspection was similar to that for rust. The target plate was focused on first, and then the length of the crack was measured using image processing. Its width was not measured but was calculated using the crack area and length. For each system developed to approach each task, the results of the preliminary experiment and those of WRS2020 are shown. Finally, the approaches are summarized, and planned future work is discussed.
en-copyright=
kn-copyright=

en-aut-name=ShimizuYuya
en-aut-sei=Shimizu
en-aut-mei=Yuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KamegawaTetsushi
en-aut-sei=Kamegawa
en-aut-mei=Tetsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WangYongdong
en-aut-sei=Wang
en-aut-mei=Yongdong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TamuraHajime
en-aut-sei=Tamura
en-aut-mei=Hajime
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TeshimaTaiga
en-aut-sei=Teshima
en-aut-mei=Taiga
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NakanoSota
en-aut-sei=Nakano
en-aut-mei=Sota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TadaYuki
en-aut-sei=Tada
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NakanoDaiki
en-aut-sei=Nakano
en-aut-mei=Daiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SasakiYuichi
en-aut-sei=Sasaki
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=SekitoTaiga
en-aut-sei=Sekito
en-aut-mei=Taiga
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=UtsumiKeisuke
en-aut-sei=Utsumi
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=NagaoRai
en-aut-sei=Nagao
en-aut-mei=Rai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=SembaMizuki
en-aut-sei=Semba
en-aut-mei=Mizuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Okayama University
kn-affil=

affil-num=2
en-affil=Okayama University
kn-affil=

affil-num=3
en-affil=Okayama University
kn-affil=

affil-num=4
en-affil=Okayama University
kn-affil=

affil-num=5
en-affil=Okayama University
kn-affil=

affil-num=6
en-affil=Okayama University
kn-affil=

affil-num=7
en-affil=Okayama University
kn-affil=

affil-num=8
en-affil=Okayama University
kn-affil=

affil-num=9
en-affil=Okayama University
kn-affil=

affil-num=10
en-affil=Okayama University
kn-affil=

affil-num=11
en-affil=Okayama University
kn-affil=

affil-num=12
en-affil=Okayama University
kn-affil=

affil-num=13
en-affil=Okayama University
kn-affil=
en-keyword=WRS2020
kn-keyword=WRS2020
en-keyword=image processing
kn-keyword=image processing
en-keyword=auto inspection
kn-keyword=auto inspection
en-keyword=YOLO
kn-keyword=YOLO
en-keyword=OCR
kn-keyword=OCR
END

start-ver=1.4
cd-journal=joma
no-vol=17
cd-vols=
no-issue=3-4
article-no=
start-page=116
end-page=125
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Deep Reinforcement Learning Enabled Adaptive Virtual Machine Migration Control in Multi-Stage Information Processing Systems
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This paper tackles a Virtual Machine (VM) migration control problem to maximize the progress (accuracy) of information processing tasks in multi-stage information processing systems. The conventional methods for this problem are effective only for specific situations, such as when the system load is high. In this paper, in order to adaptively achieve high accuracy in various situations, we propose a VM migration method using a Deep Reinforcement Learning (DRL) algorithm. It is difficult to directly apply a DRL algorithm to the VM migration control problem because the size of the solution space of the problem dynamically changes according to the number of VMs staying in the system while the size of the agent�fs action space is fixed in DRL algorithms. To cope with this difficulty, the proposed method divides the VM migration control problem into two problems: the problem of determining only the VM distribution (i.e., the proportion of the number of VMs deployed on each edge server) and the problem of determining the locations of all the VMs so that it follows the determined VM distribution. The former problem is solved by a DRL algorithm, and the latter by a heuristic method. This approach makes it possible to apply a DRL algorithm to the VM migration control problem because the VM distribution is expressed by a vector with a fixed number of dimensions and can be directly outputted by the agent. The simulation results confirm that our proposed method can adaptively achieve quasi-optimal accuracy in various situations with different link delays, types of the information processing tasks and the number of VMs.
en-copyright=
kn-copyright=

en-aut-name=FukushimaYukinobu
en-aut-sei=Fukushima
en-aut-mei=Yukinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KoujitaniYuki
en-aut-sei=Koujitani
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakaneKazutoshi
en-aut-sei=Nakane
en-aut-mei=Kazutoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TarutaniYuya
en-aut-sei=Tarutani
en-aut-mei=Yuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WuCelimuge
en-aut-sei=Wu
en-aut-mei=Celimuge
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=JiYusheng
en-aut-sei=Ji
en-aut-mei=Yusheng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YokohiraTokumi
en-aut-sei=Yokohira
en-aut-mei=Tokumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MuraseTutomu
en-aut-sei=Murase
en-aut-mei=Tutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Faculty of Environmental, Life, Natural Science and Technology Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Information Science Nagoya University
kn-affil=

affil-num=4
en-affil=Graduate School of Engineering Osaka University
kn-affil=

affil-num=5
en-affil=Graduate School of Informatics and Engineering The Univ. of Electro-Commun.
kn-affil=

affil-num=6
en-affil=Information Systems Architecture Research Division National Institute of Informatics
kn-affil=

affil-num=7
en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems Okayama University
kn-affil=

affil-num=8
en-affil=Graduate School of Information Science Nagoya University
kn-affil=
en-keyword=Multi-stage information processing system
kn-keyword=Multi-stage information processing system
en-keyword=VM migration control
kn-keyword=VM migration control
en-keyword=Deep reinforcement learning
kn-keyword=Deep reinforcement learning
en-keyword=Deep Deterministic Policy Gradient (DDPG)
kn-keyword=Deep Deterministic Policy Gradient (DDPG)
END

start-ver=1.4
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kn-title=STUDY ON VALUE PRODUCTION THROUGH MICROALGAE CULTIVATION FROM EFFLUENT IN HYDROPONIC AGRICULTURAL SYSTEM 
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en-aut-name=MANABEKyohei
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en-title=IoTƒAƒvƒŠƒP�[ƒVƒ‡ƒ“�EƒVƒXƒeƒ€‚Ì‚½‚ß‚Ì“��‡ƒT�[ƒo�Eƒvƒ‰ƒbƒgƒtƒH�[ƒ€‚ÉŠÖ‚·‚錤‹†
kn-title=A Study of Integrated Server Platform for IoT Application Systems
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en-aut-name=YOHANES YOHANIE FRIDELIN PANDUMAN
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kn-title=A Study of Uniform Job Assignment Algorithms to Workers in User-PC Computing System
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en-aut-name=ZHOUXUDONG
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en-title=ƒvƒ�ƒOƒ‰ƒ~ƒ“ƒOŠw�KŽx‰‡ƒVƒXƒeƒ€‚É‚¨‚¯‚éPythonƒR�[ƒh‹L�q–â‘è‚ÆC++’lƒgƒŒ�[ƒX–â‘è‚ÉŠÖ‚·‚錤‹†
kn-title=A Study of Python Code Writing Problem and C++ Value Trace Problem for Programming Learning Assistant Systems
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en-aut-name=SHUNE LAE AUNG
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en-aut-name=SEKIGUCHIManabu
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en-title=CRISPR-Cas9ƒVƒXƒeƒ€‚ð—p‚¢‚½—ì’·—Þ“ÁˆÙ“I’·�½ƒmƒ“ƒR�[ƒfƒBƒ“ƒORNA, UCA1ƒmƒbƒNƒCƒ“ƒ}ƒEƒX‚Ì�ì�»‚Ɖð�Í‚Ö‚Ì’§�í
kn-title=Challenges of Generation and Analysis of Knock-in Mice Harboring a Primate-Specific Long Non-Coding RNA, UCA1 with CRISPR-Cas9 System
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en-aut-name=Panneer Selvam Kavitha
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affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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en-title=ŒŒ’†�zŠÂ—V—£DNA‚̃�ƒ`ƒ‹‰»ƒpƒ^�[ƒ“‚Í�AŒ´”­‘ƒˆâ“`Žq•ÏˆÙƒvƒ�ƒtƒ@ƒCƒ‹‚É‚æ‚炸�A‘å’°Šà‚ÌŽ¡—ÃŒø‰Êƒ‚ƒjƒ^ƒŠƒ“ƒO‚ð‰Â”\‚Æ‚·‚é”ñ�N�P“I‚ȃoƒCƒIƒ}�[ƒJ�[‚Å‚ ‚é
kn-title=Circulating cell?free DNA methylation patterns as non?invasive biomarkers to monitor colorectal cancer treatment efficacy without referencing primary site mutation profiles
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en-aut-name=YASUIKazuya
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affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘��‡Œ¤‹†‰È
END

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cd-journal=joma
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dt-pub-year=2024
dt-pub=20241106
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en-title=
kn-title=Distribution and Incorporation of Extracellular Vesicles into Chondrocytes and Synoviocytes
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kn-subtitle=
en-abstract=
kn-abstract=Osteoarthritis (OA) is a chronic disease affecting over 500 million people worldwide. As the population ages and obesity rates rise, the societal burden of OA is increasing. Pro-inflammatory cytokines, particularly interleukin-1ƒÀ, are implicated in the pathogenesis of OA. Recent studies suggest that crosstalk between cartilage and synovium contributes to OA development, but the mechanisms remain unclear. Extracellular vesicles (EVs) were purified from cell culture-conditioned medium via ultracentrifugation and confirmed using transmission electron microscopy, nanoparticle tracking analysis, and western blotting. We demonstrated that EVs were taken up by human synoviocytes and chondrocytes in vitro, while in vivo experiments revealed that fluorescent-labelled EVs injected into mouse joints were incorporated into chondrocytes and synoviocytes. EV uptake was significantly inhibited by dynamin-mediated endocytosis inhibitors, indicating that endocytosis plays a major role in this process. Additionally, co-culture experiments with HEK-293 cells expressing red fluorescent protein (RFP)-tagged CD9 and the chondrocytic cell line OUMS-27 confirmed the transfer of RFP-positive EVs across a 600-nm but not a 30-nm filter. These findings suggest that EVs from chondrocytes are released into joint fluid and taken up by cells within the cartilage, potentially facilitating communication between cartilage and synovium. The results underscore the importance of EVs in OA pathophysiology.
en-copyright=
kn-copyright=

en-aut-name=OhtsukiTakashi
en-aut-sei=Ohtsuki
en-aut-mei=Takashi
kn-aut-name=
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ORCID=

en-aut-name=SatoIkumi
en-aut-sei=Sato
en-aut-mei=Ikumi
kn-aut-name=
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kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakashitaRen
en-aut-sei=Takashita
en-aut-mei=Ren
kn-aut-name=
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kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KodamaShintaro
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en-aut-mei=Shintaro
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ORCID=

en-aut-name=IkemuraKentaro
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en-aut-mei=Kentaro
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aut-affil-num=5
ORCID=

en-aut-name=OpokuGabriel
en-aut-sei=Opoku
en-aut-mei=Gabriel
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ORCID=

en-aut-name=WatanabeShogo
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ORCID=

en-aut-name=FurumatsuTakayuki
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en-aut-mei=Takayuki
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kn-aut-mei=
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ORCID=

en-aut-name=YamadaHiroshi
en-aut-sei=Yamada
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=AndoMitsuru
en-aut-sei=Ando
en-aut-mei=Mitsuru
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=AkiyoshiKazunari
en-aut-sei=Akiyoshi
en-aut-mei=Kazunari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=NishidaKeiichiro
en-aut-sei=Nishida
en-aut-mei=Keiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=HirohataSatoshi
en-aut-sei=Hirohata
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Orthopedic Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=9
en-affil=Department of Neuroscience, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=10
en-affil=Laboratory of Biomaterials, Institute for Life and Medical Sciences, Kyoto University
kn-affil=

affil-num=11
en-affil=Department of Immunology, Graduate School of Medicine, Kyoto University
kn-affil=

affil-num=12
en-affil=Department of Orthopedic Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=13
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=
en-keyword=extracellular vesicles (EVs)
kn-keyword=extracellular vesicles (EVs)
en-keyword=chondrocytes
kn-keyword=chondrocytes
en-keyword=synoviocytes
kn-keyword=synoviocytes
en-keyword=osteoarthritis (OA)
kn-keyword=osteoarthritis (OA)
END

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cd-journal=joma
no-vol=65
cd-vols=
no-issue=10
article-no=
start-page=1488
end-page=1500
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241015
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kn-subject=
en-title=A Method for Inter-Broadcaster Data Integration of Non-Identifiable Television Viewing Log
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en-subtitle=
kn-subtitle=
en-abstract=Recently, TV broadcasters have been collecting and utilizing non-personal TV viewing log data, including start and end times of viewing, from TVs connected to the Internet in a format that does not identify individual viewers. However, since each broadcaster can only use its own non-personal TV viewing log data, it has not yet been able to obtain useful knowledge despite the vast amount of data it has accumulated. In addition, the collection methods and data granularity of non-personal TV viewing log data vary from station to station, and the data accumulated by each station cannot be integrated and used. In this paper, we propose a method for matching non-specific viewing history data collected by each broadcaster using its own method, and design and implement a simulator to evaluate the proposed method. The proposed method estimates that TVs whose channel transition timing matches five items collected at the time of viewing history data collection (IP address, zip code, manufacturer ID, browser major version, and browser minor version) are the same TVs. In addition, we designed a simulator that reproduces viewer behavior and applied this method to the viewing history data synthesized from the simulator. As a result, we succeeded in matching approximately 2.41 million TVs out of the 2.5 million units of data generated, showing an identification rate of 96.5%.
kn-abstract=‹ß”N�CŠeƒeƒŒƒr•ú‘—‹Ç‚É‚¨‚¢‚Ä�CŒÂ�l‚ð“Á’肵‚È‚¢Œ`Ž®‚Å�CƒCƒ“ƒ^�[ƒlƒbƒg�Ú‘±‚³‚ꂽƒeƒŒƒr‚©‚王’®ŠJŽnŽž��‚⎋’®�I—¹Žž��“™‚ðŠÜ‚Þ”ñ“Á’莋’®—š—ðƒf�[ƒ^‚ðŽû�W‚µ�C—˜Šˆ—p‚·‚éŽæ‚è‘g‚Ý‚ª�i‚ß‚ç‚ê‚Ä‚¢‚é�D‚µ‚©‚µ�CŠe•ú‘—‹Ç‚ÍŽ©‹Ç‚Ì”ñ“Á’莋’®—š—ðƒf�[ƒ^‚µ‚©—˜—p‚Å‚«‚È‚¢‚½‚ß�C–c‘å‚ȃf�[ƒ^‚ð’~�Ï‚µ‚Ä‚¢‚é‚É‚à‚©‚©‚í‚炸�C—L—p‚È’mŒ©‚𓾂é‚Ü‚Å‚ÉŽŠ‚Á‚Ä‚¢‚È‚¢‚Ì‚ªŒ»�ó‚Å‚ ‚é�D‚³‚ç‚É�C”ñ“Á’莋’®—š—ðƒf�[ƒ^‚ÌŽû�W•ûŽ®‚âƒf�[ƒ^—±“x‚Í�CŠe‹ÇŠe—l‚Æ‚È‚Á‚Ä‚¨‚è�CŠe‹Ç‚ª’~�Ï‚µ‚½ƒf�[ƒ^‚ð“��‡‚µ�C—˜—p‚·‚邱‚Æ‚à‚Å‚«‚Ä‚¢‚È‚¢�D‚»‚±‚Å–{˜_•¶‚Å‚Í�CŠe‹Ç‚ª“ÆŽ©‚Ì•ûŽ®‚Ŏ擾‚µ‚Ä‚¢‚é”ñ“Á’莋’®—š—ðƒf�[ƒ^‚ð•ú‘—‹ÇŠÔ‚Å“��‡‚·‚éŽè–@‚ð’ñˆÄ‚µ�C•]‰¿‚·‚邽‚߂̃Vƒ~ƒ…ƒŒ�[ƒ^�ÝŒv‚ÆŽÀ‘•‚ð�s‚¢�C’ñˆÄŽè–@‚Ì•]‰¿‚ð�s‚¤�D<br>
’ñˆÄŽè–@‚Å‚Í�CŠe‹Ç‚ÌŽ‹’®—š—ðƒf�[ƒ^‚Ì‚¤‚¿�C‹¤’Ê‚µ‚Ä‚¢‚éIPƒAƒhƒŒƒX�E—X•Ö”Ô�†�Eƒ��[ƒJID�Eƒuƒ‰ƒEƒUƒ�ƒWƒƒ�[ƒo�[ƒWƒ‡ƒ“�Eƒuƒ‰ƒEƒUƒ}ƒCƒi�[ƒo�[ƒWƒ‡ƒ“‚Ì5�€–ڂŃeƒŒƒrŽó‘œ‹@‚𕪗£�ˆ—�‚·‚é�D‚»‚µ‚Ä�C•ª—£‚³‚ꂽ’†‚Å‚±‚ê‚ç‚Ì5�€–Ú‚ªˆê’v‚·‚éƒeƒŒƒr‚Ì‚¤‚¿�C‚³‚ç‚Ƀ`ƒƒƒ“ƒlƒ‹‘JˆÚŽž��‚ªˆê’v‚·‚éƒeƒŒƒr‚𓯈êƒeƒŒƒr‚Æ�„’è‚·‚é�D‚Ü‚½�CŽ‹’®ŽÒ�s“®‚ð�ÄŒ»‚·‚éƒVƒ~ƒ…ƒŒ�[ƒ^‚ð�ÝŒv‚µ�C‚»‚̃Vƒ~ƒ…ƒŒ�[ƒ^‚©‚ç�‡�¬‚³‚ꂽŽ‹’®—š—ðƒf�[ƒ^‚ɑ΂µ‚Ä�C–{Žè–@‚ð“K—p‚µ‚½Œ‹‰Ê�C�¶�¬‚³‚ꂽ250–œ‘䕪‚̃f�[ƒ^‚Ì‚¤‚¿–ñ241–œ‘ä‚̃eƒŒƒrID‚̃}ƒbƒ`ƒ“ƒO‚É�¬Œ÷‚µ�C�ÄŒ»—¦96.5%‚Å‚ ‚邱‚Æ‚ðŽ¦‚µ‚½�D
en-copyright=
kn-copyright=

en-aut-name=MatsudaHiroki
en-aut-sei=Matsuda
en-aut-mei=Hiroki
kn-aut-name=�¼“c—T‹M
kn-aut-sei=�¼“c
kn-aut-mei=—T‹M
aut-affil-num=1
ORCID=

en-aut-name=SakakibaraTaichi
en-aut-sei=Sakakibara
en-aut-mei=Taichi
kn-aut-name=�匴‘¾ˆê
kn-aut-sei=�匴
kn-aut-mei=‘¾ˆê
aut-affil-num=2
ORCID=

en-aut-name=MayumiDaiki
en-aut-sei=Mayumi
en-aut-mei=Daiki
kn-aut-name=�^‹|‘å‹P
kn-aut-sei=�^‹|
kn-aut-mei=‘å‹P
aut-affil-num=3
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en-aut-name=MatsudaYuki
en-aut-sei=Matsuda
en-aut-mei=Yuki
kn-aut-name=�¼“c—T‹M
kn-aut-sei=�¼“c
kn-aut-mei=—T‹M
aut-affil-num=4
ORCID=

en-aut-name=MizumotoTeruhiro
en-aut-sei=Mizumoto
en-aut-mei=Teruhiro
kn-aut-name=�…–{ˆ®—m
kn-aut-sei=�…–{
kn-aut-mei=ˆ®—m
aut-affil-num=5
ORCID=

en-aut-name=YasumotoKeiichi
en-aut-sei=Yasumoto
en-aut-mei=Keiichi
kn-aut-name=ˆÀ–{Œcˆê
kn-aut-sei=ˆÀ–{
kn-aut-mei=Œcˆê
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Nara Institute of Science and Technology
kn-affil=“Þ—Ç�æ’[‰ÈŠw‹Z�p‘åŠw‰@‘åŠw

affil-num=2
en-affil=Yomiuri Telecasting Corporation
kn-affil=æ¤æ̃eƒŒƒr•ú‘—Š”Ž®‰ïŽÐ

affil-num=3
en-affil=Nara Institute of Science and Technology
kn-affil=“Þ—Ç�æ’[‰ÈŠw‹Z�p‘åŠw‰@‘åŠw

affil-num=4
en-affil=Okayama University
kn-affil=‰ªŽR‘åŠw

affil-num=5
en-affil=Chiba Institute of Technology
kn-affil=�ç—t�H‹Æ‘åŠw

affil-num=6
en-affil=Nara Institute of Science and Technology
kn-affil=“Þ—Ç�æ’[‰ÈŠw‹Z�p‘åŠw‰@‘åŠw
en-keyword=ƒeƒŒƒr (TV)
kn-keyword=ƒeƒŒƒr (TV)
en-keyword=Ž‹’®—š—ðƒf�[ƒ^ (TV viewing log data)
kn-keyword=Ž‹’®—š—ðƒf�[ƒ^ (TV viewing log data)
en-keyword=ƒrƒbƒOƒf�[ƒ^ (Big data)
kn-keyword=ƒrƒbƒOƒf�[ƒ^ (Big data)
en-keyword=IoT
kn-keyword=IoT
en-keyword=ƒNƒ�ƒXƒfƒoƒCƒXƒ}ƒbƒ`ƒ“ƒO (Cross-device matching)
kn-keyword=ƒNƒ�ƒXƒfƒoƒCƒXƒ}ƒbƒ`ƒ“ƒO (Cross-device matching)
en-keyword=ƒNƒ�ƒXƒfƒoƒCƒXƒgƒ‰ƒbƒLƒ“ƒO (Cross-device tracking)
kn-keyword=ƒNƒ�ƒXƒfƒoƒCƒXƒgƒ‰ƒbƒLƒ“ƒO (Cross-device tracking)
END

start-ver=1.4
cd-journal=joma
no-vol=56
cd-vols=
no-issue=2
article-no=
start-page=41
end-page=71
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241125
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Reproducing Self-organizing Agglomeration using Agent-based Model: ICT Establishments in Tokyo�fs Special Wards
kn-title=ƒG�[ƒWƒFƒ“ƒgƒx�[ƒXƒ‚ƒfƒ‹‚É‚æ‚鎩ŒÈ‘g�D‰»“I�W�Ï‚Ì�ÄŒ»�F“Á•Ê‹æ‚É‚¨‚¯‚éICT Ž–‹Æ�Š
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=�@As a preliminary step to conducting a self-organizing simulation of the agglomeration and dispersion of the information and communications industry, we quantify the spatial agglomeration of the information and communications industry in Japan�fs major cities. Using the town and district data from the Economic Census for Economic Activity, we attempted a spatial analysis of the information and communications industry in the Tokyo Special Wards as well as in Sapporo, Sendai, Hiroshima, and Fukuoka, which have regional central functions. As a result of detecting spatial autocorrelation in small areas within each city, hotspots indicating the agglomeration of information and communications industry offi ces were found in the city center of each city. At the same time, we were able to confi rm the impact of agglomeration economies, which are the premise of the self-organizing model, and confi rmed that the information and communications industry is an industry suitable for simulation of the self-organizing model.
�@Krugman�i1996�jwas the fi rst to model the self-organizing model in cities and clarifi ed the emergence principle of peripheral cities, but this was limited to numerical simulations. Later, Kumar et al.�i2007�jused actual data to show that Krugman�fs self-organizing model could be applied to predict corporate agglomeration and dispersion. In this paper, we use an agent-based model to examine whether a self-organizing model is also effective in reproducing and predicting the concentration and dispersion of the information and communications industry in Japanese cities.
en-copyright=
kn-copyright=

en-aut-name=NakamuraRyohei
en-aut-sei=Nakamura
en-aut-mei=Ryohei
kn-aut-name=’†‘º—Ç•½
kn-aut-sei=ՠԼ
kn-aut-mei=—Ç•½
aut-affil-num=1
ORCID=

en-aut-name=NagamuneTakeshi
en-aut-sei=Nagamune
en-aut-mei=Takeshi
kn-aut-name=’·�@•�Ži
kn-aut-sei=’·�@
kn-aut-mei=•�Ži
aut-affil-num=2
ORCID=

en-aut-name=HayashiSyusei
en-aut-sei=Hayashi
en-aut-mei=Syusei
kn-aut-name=—Ñ�G�¯
kn-aut-sei=—Ñ
kn-aut-mei=�G�¯
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠw

affil-num=2
en-affil=
kn-affil=�VŒ©Œö—§‘åŠw

affil-num=3
en-affil=
kn-affil=“Œ–k‘åŠw‘åŠw‰@
END

start-ver=1.4
cd-journal=joma
no-vol=56
cd-vols=
no-issue=2
article-no=
start-page=1
end-page=16
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241125
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Why Is Intermediate Organization Necessary?
kn-title=‚È‚º’†ŠÔ‘g�D‚ª•K—v‚È‚Ì‚©
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=�@This paper challenges a fundamental question, �eWhy is an intermediate organization necessary?�f Due to transaction costs and market failures on the one hand and the limitations of organizational control mechanisms on the other hand, many�e intermediate organizations�f are observed in the real world. How can we tackle to explain the governance mechanism considered to be�e intermediate?�f
�@If we are to discuss such socioeconomic orders, this paper assumes that we should not be able to link micro-level explanations and macro-level ones concerning the third mode of governance mechanisms all at once. We need to stick to the meso-level at fi rst. The theoretical elaboration since Ouchi�fs�i1980�j discussion of clan-type governance and cumulative empirical research on industrial agglomerations have allowed us to construct a more sophisticated theory called community capital.
�@In effective communities, members are �eembedded as insiders�f who serve the purpose of the community, share experiences of failures and successes, and find and deepen their common identity. This limited membership is bound by�e mutual trust to rely on each other�f for�e distribution of short-term risks.�f In contrast to social norms that need to be abstract enough to be widely shared, the communal norms that are concrete enough to allow the members to understand without hesitation how they should behave in localized contexts are cumulatively cultivated along socializing process. Among the norms, sense of mutual obligation to incur intermittent costs for the whole community is a crucial norm for the sustainable development of the community. However, as a practical matter, membership control, mutual trust and short-term risk allocation may serve the communities in the short run, but they do not guarantee long-term accumulation of shared capital. As a result, the limits of community capital may need to be discussed once again, especially today when market liquidity is increasing, and its failures tend to become more apparent in a variety of areas.
en-copyright=
kn-copyright=

en-aut-name=FujiiDaiji
en-aut-sei=Fujii
en-aut-mei=Daiji
kn-aut-name=“¡ˆä‘厙
kn-aut-sei=“¡ˆä
kn-aut-mei=‘厙
aut-affil-num=1
ORCID=

en-aut-name=OshimaTamako
en-aut-sei=Oshima
en-aut-mei=Tamako
kn-aut-name=‘哇ŽìŽq
kn-aut-sei=‘哇
kn-aut-mei=ŽìŽq
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“��‡‰ÈŠwŠwˆæ

affil-num=2
en-affil=
kn-affil=�‘�Ûˆã—ÕŸŽƒ‘åŠw�¬“cŒ´•ÛŒ’ˆã—Êw•”ŠÅŒìŠw‰È
en-keyword=’†ŠÔ‘g�D
kn-keyword=’†ŠÔ‘g�D
en-keyword=“à•”‘g�D‚ÌŒo�ÏŠw
kn-keyword=“à•”‘g�D‚ÌŒo�ÏŠw
en-keyword=ŽY‹Æ�W�Ï
kn-keyword=ŽY‹Æ�W�Ï
en-keyword=ƒRƒ~ƒ…ƒjƒeƒB�EƒLƒƒƒsƒ^ƒ‹
kn-keyword=ƒRƒ~ƒ…ƒjƒeƒB�EƒLƒƒƒsƒ^ƒ‹
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=
article-no=
start-page=146551
end-page=146559
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240925
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Protection Scheme With Speech Processing Against Audio Adversarial Examples
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Machine learning technologies have improved the accuracy of speech recognition systems, and devices using those systems, such as smart speakers and AI assistants, are now in wide use. However, speech recognition systems have security vulnerabilities. In particular, a known machine learning vulnerability called audio adversarial examples (AAEs), which causes misrecognition in speech recognition systems, has become a problem. We propose a scheme for using speech processing to protect speech recognition systems from AAEs, preventing misrecognitions by slight processing of input speech that does not affect the recognition of normal speech. We use two kinds of processing: speed and frequency. Evaluation results show that the proposed scheme can reduce the success rate of attack speech to about 1% while maintaining about 85% recognition rates for normal speech.
en-copyright=
kn-copyright=

en-aut-name=TarutaniYuya
en-aut-sei=Tarutani
en-aut-mei=Yuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamamotoTaisei
en-aut-sei=Yamamoto
en-aut-mei=Taisei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FukushimaYukinobu
en-aut-sei=Fukushima
en-aut-mei=Yukinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YokohiraTokumi
en-aut-sei=Yokohira
en-aut-mei=Tokumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=Speech recognition system
kn-keyword=Speech recognition system
en-keyword=security
kn-keyword=security
en-keyword=audio adversarial example
kn-keyword=audio adversarial example
END

start-ver=1.4
cd-journal=joma
no-vol=112
cd-vols=
no-issue=2
article-no=
start-page=419
end-page=424
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240909
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Electrochemically assisted sol-gel deposition of bioactive gels for biomedical applications
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=So far, the sol-gel process has been available to prepare precursor gels of bioactive glasses with various compositions. In this report, we described a novel coating method of bioactive gels on a titanium substrate where the sol-gel transition is controlled by applying external electric fields. The application of a constant current of 10?mA/cm2 in an acidic sol containing pre-hydrolyzed tetraethoxysilane, calcium nitrate, and ammonium dihydrogen phosphate led to the deposition of gels on the titanium cathodes due to the generation of OH? by water electrolysis as a catalyst of the sol-gel transition. The obtained gels, which were characterized to be amorphous and consisted of Si, Ca, and P, covered the titanium substrates as a coating. The bioactivity of the gels deposited was confirmed by soaking in a simulated body fluid (SBF) up to 7 days, suggesting that the electrochemically assisted sol-gel process is promising for providing bioactive coatings on metallic implants.
en-copyright=
kn-copyright=

en-aut-name=YoshiokaTomohiko
en-aut-sei=Yoshioka
en-aut-mei=Tomohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MiyamotoNaoki
en-aut-sei=Miyamoto
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HayakawaSatoshi
en-aut-sei=Hayakawa
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Biomaterials Laboratory, Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Biomaterials Laboratory, Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=Sol-gel-derived gels
kn-keyword=Sol-gel-derived gels
en-keyword=Coating
kn-keyword=Coating
en-keyword=Water electrolysis
kn-keyword=Water electrolysis
en-keyword=Bioactivity
kn-keyword=Bioactivity
en-keyword=SBF
kn-keyword=SBF
END

start-ver=1.4
cd-journal=joma
no-vol=186
cd-vols=
no-issue=
article-no=
start-page=79
end-page=89
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=High School Teachers�f Questions and Resource Rooms Teachers�f Explanations during Introductory Stage
kn-title=’Ê‹‰‚É‚æ‚éŽw“±‚Ì“±“üŠú‚É‚¨‚¯‚é�‚�Z‹³ˆõ‚ÌŽ¿–â‚Æ’Ê‹‰’S“–‚Ì�à–¾�\ �Z“à‘Ì�§‚Ì�®”õ‰ß’ö‚ÉŠÖ‚·‚éŽÀ‘H•ñ�� �\
en-subtitle=
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en-title=The current situation and challenges regarding immigration issues in the Republic of Estonia : Focusing on the process of integration policies after the �g2007 riot�h.
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en-title=Der moderne Staat und das Nationalit?tenprinzip
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cd-journal=joma
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kn-title=In Vitro Study of Tumor-Homing Peptide-Modified Magnetic Nanoparticles for Magnetic Hyperthermia
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kn-abstract=Cancer cells have higher heat sensitivity compared to normal cells; therefore, hyperthermia is a promising approach for cancer therapy because of its ability to selectively kill cancer cells by heating them. However, the specific and rapid heating of tumor tissues remains challenging. This study investigated the potential of magnetic nanoparticles (MNPs) modified with tumor-homing peptides (THPs), specifically PL1 and PL3, for tumor-specific magnetic hyperthermia therapy. The synthesis of THP-modified MNPs involved the attachment of PL1 and PL3 peptides to the surface of the MNPs, which facilitated enhanced tumor cell binding and internalization. Cell specificity studies revealed an increased uptake of PL1- and PL3-MNPs by tumor cells compared to unmodified MNPs, indicating their potential for targeted delivery. In vitro hyperthermia experiments demonstrated the efficacy of PL3-MNPs in inducing tumor cell death when exposed to an alternating magnetic field (AMF). Even without exposure to an AMF, an additional ferroptotic pathway was suggested to be mediated by the nanoparticles. Thus, this study suggests that THP-modified MNPs, particularly PL3-MNPs, hold promise as a targeted approach for tumor-specific magnetic hyperthermia therapy.
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en-aut-name=ZhouShengli
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en-aut-name=TsutsumiuchiKaname
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en-aut-name=ImaiRitsuko
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en-aut-name=MikiYukiko
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en-aut-name=OhtsukiTakashi
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affil-num=1
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
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affil-num=2
en-affil=College of Bioscience and Biotechnology, Chubu University
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affil-num=3
en-affil=College of Bioscience and Biotechnology, Chubu University
kn-affil=

affil-num=4
en-affil=College of Bioscience and Biotechnology, Chubu University
kn-affil=

affil-num=5
en-affil=College of Bioscience and Biotechnology, Chubu University
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affil-num=6
en-affil=College of Bioscience and Biotechnology, Chubu University
kn-affil=

affil-num=7
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=tumor-homing peptide
kn-keyword=tumor-homing peptide
en-keyword=magnetic hyperthermia
kn-keyword=magnetic hyperthermia
en-keyword=magnetic nanoparticles
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kn-title=Dissection of the signal transduction machinery responsible for the lysyl oxidase-like 4-mediated increase in invasive motility in triple-negative breast cancer cells: mechanistic insight into the integrin-ƒÀ1-NF-ƒÈB-MMP9 axis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background Triple-negative breast cancer (TNBC) cells are a highly formidable cancer to treat. Nonetheless, by continued investigation into the molecular biology underlying the complex regulation of TNBC cell activity, vulnerabilities can be exposed as potential therapeutic targets at the molecular level. We previously revealed that lysyl oxidase-like 4 (LOXL4) promotes the invasiveness of TNBC cells via cell surface annexin A2 as a novel binding substrate of LOXL4, which promotes the abundant localization of integrin-beta 1 at the cancer plasma membrane. However, it has yet to be uncovered how the LOXL4-mediated abundance of integrin-beta 1 hastens the invasive outgrowth of TNBC cells at the molecular level.<br>
Methods LOXL4-overexpressing stable clones were established from MDA-MB-231 cells and subjected to molecular analyses, real-time qPCR and zymography to clarify their invasiveness, signal transduction, and matrix metalloprotease (MMP) activity, respectively.<br>
Results Our results show that LOXL4 potently promotes the induction of matrix metalloprotease 9 (MMP9) via activation of nuclear factor-kappa B (NF-kappa B). Our molecular analysis revealed that TNF receptor-associated factor 4 (TRAF4) and TGF-beta activated kinase 1 (TAK1) were required for the activation of NF-kappa B through I kappa beta kinase kinase (IKK alpha/beta) phosphorylation.<br>
Conclusion Our results demonstrate that the newly identified LOXL4-mediated axis, integrin-beta 1-TRAF4-TAK1-IKK alpha/beta-I kappa beta alpha-NF-kappa B-MMP9, is crucial for TNBC cell invasiveness.
en-copyright=
kn-copyright=

en-aut-name=JiangFan
en-aut-sei=Jiang
en-aut-mei=Fan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ChenYouyi
en-aut-sei=Chen
en-aut-mei=Youyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TomonobuNahoko
en-aut-sei=Tomonobu
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KinoshitaRie
en-aut-sei=Kinoshita
en-aut-mei=Rie
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KomalasariNi Luh Gede Yoni
en-aut-sei=Komalasari
en-aut-mei=Ni Luh Gede Yoni
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=Kasano-CamonesCarlos Ichiro
en-aut-sei=Kasano-Camones
en-aut-mei=Carlos Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NinomiyaKazumi
en-aut-sei=Ninomiya
en-aut-mei=Kazumi
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MurataHitoshi
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kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YamamotoKen-Ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-Ichi
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=GoharaYuma
en-aut-sei=Gohara
en-aut-mei=Yuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OchiToshiki
en-aut-sei=Ochi
en-aut-mei=Toshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=RumaI. Made Winarsa
en-aut-sei=Ruma
en-aut-mei=I. Made Winarsa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=SumardikaI. Wayan
en-aut-sei=Sumardika
en-aut-mei=I. Wayan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=ZhouJin
en-aut-sei=Zhou
en-aut-mei=Jin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=HonjoTomoko
en-aut-sei=Honjo
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=SakaguchiYoshihiko
en-aut-sei=Sakaguchi
en-aut-mei=Yoshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=YamauchiAkira
en-aut-sei=Yamauchi
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=KuribayashiFutoshi
en-aut-sei=Kuribayashi
en-aut-mei=Futoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=FutamiJunichiro
en-aut-sei=Futami
en-aut-mei=Junichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=KondoEisaku
en-aut-sei=Kondo
en-aut-mei=Eisaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=InoueYusuke
en-aut-sei=Inoue
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Breast Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=6
en-affil=Faculty of Science and Technology, Division of Molecular Science, Gunma University
kn-affil=

affil-num=7
en-affil=Faculty of Science and Technology, Division of Molecular Science, Gunma University
kn-affil=

affil-num=8
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=13
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=14
en-affil=Medical Oncology Department of Gastrointestinal Tumors, Liaoning Cancer Hospital & Institute, Cancer Hospital of the Dalian University of Technology
kn-affil=

affil-num=15
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=16
en-affil=Department of Microbiology, Tokushima Bunri University
kn-affil=

affil-num=17
en-affil=Department of Biochemistry, Kawasaki Medical School
kn-affil=

affil-num=18
en-affil=Department of Biochemistry, Kawasaki Medical School
kn-affil=

affil-num=19
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=20
en-affil=Division of Tumor Pathology, Near InfraRed Photo-Immuno-Therapy Research Institute, Kansai Medical University
kn-affil=

affil-num=21
en-affil=Faculty of Science and Technology, Division of Molecular Science, Gunma University
kn-affil=

affil-num=22
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=23
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=breast cancer
kn-keyword=breast cancer
en-keyword=invasion
kn-keyword=invasion
en-keyword=lysyl oxidase
kn-keyword=lysyl oxidase
en-keyword=NF-ƒÈB
kn-keyword=NF-ƒÈB
en-keyword=MMP9
kn-keyword=MMP9
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=5
article-no=
start-page=414
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240424
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Go/No-Go Ratios Modulate Inhibition-Related Brain Activity: An Event-Related Potential Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=(1) Background: Response inhibition refers to the conscious ability to suppress behavioral responses, which is crucial for effective cognitive control. Currently, research on response inhibition remains controversial, and the neurobiological mechanisms associated with response inhibition are still being explored. The Go/No-Go task is a widely used paradigm that can be used to effectively assess response inhibition capability. While many studies have utilized equal numbers of Go and No-Go trials, how different ratios affect response inhibition remains unknown; (2) Methods: This study investigated the impact of different ratios of Go and No-Go conditions on response inhibition using the Go/No-Go task combined with event-related potential (ERP) techniques; (3) Results: The results showed that as the proportion of Go trials decreased, behavioral performance in Go trials significantly improved in terms of response time, while error rates in No-Go trials gradually decreased. Additionally, the NoGo-P3 component at the central average electrodes (Cz, C1, C2, FCz, FC1, FC2, PCz, PC1, and PC2) exhibited reduced amplitude and latency; (4) Conclusions: These findings indicate that different ratios in Go/No-Go tasks influence response inhibition, with the brain adjusting processing capabilities and rates for response inhibition. This effect may be related to the brain's predictive mechanism model.
en-copyright=
kn-copyright=

en-aut-name=ZhangNan
en-aut-sei=Zhang
en-aut-mei=Nan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AnWeichao
en-aut-sei=An
en-aut-mei=Weichao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YuYinghua
en-aut-sei=Yu
en-aut-mei=Yinghua
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=WuJinglong
en-aut-sei=Wu
en-aut-mei=Jinglong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YangJiajia
en-aut-sei=Yang
en-aut-mei=Jiajia
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=response inhibition
kn-keyword=response inhibition
en-keyword=ratio
kn-keyword=ratio
en-keyword=go/no-go task
kn-keyword=go/no-go task
en-keyword=ERP
kn-keyword=ERP
en-keyword=NoGo-P3 component
kn-keyword=NoGo-P3 component
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=13
end-page=18
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240526
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Application of a Deep Reinforcement Learning Algorithm to Virtual Machine Migration Control in Multi-Stage Information Processing Systems
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This paper tackles a Virtual Machine (VM) migration control problem to maximize the progress (accuracy) of information processing tasks in multi-stage information processing systems. The conventional methods for this problem (e.g., VM sweeping method and VM number averaging method) are effective only for specific situations, such as when the system load is high. In this paper, in order to achieve high accuracy in various situations, we propose a VM migration method using a Deep Reinforcement Learning (DRL) algorithm. It is difficult to directly apply a DRL algorithm to the VM migration control problem because the size of the solution space of the problem dynamically changes according to the number of VMs staying in the system while the size of the agent�fs action space is fixed in DRL algorithms. Therefore, the proposed method divides the VM migration control problem into two problems: the problem of determining only the VM distribution (i.e., the proportion of the number of VMs deployed on each edge server) and the problem of determining the locations of all the VMs so that it follows the determined VM distribution. The former problem is solved by a DRL algorithm, and the latter problem is solved by a heuristic method. The simulation results confirm that our proposed method can select quasi-optimal VM locations in various situations with different link delays.
en-copyright=
kn-copyright=

en-aut-name=FukushimaYukinobu
en-aut-sei=Fukushima
en-aut-mei=Yukinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KoujitaniYuki
en-aut-sei=Koujitani
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakaneKazutoshi
en-aut-sei=Nakane
en-aut-mei=Kazutoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TarutaniYuta
en-aut-sei=Tarutani
en-aut-mei=Yuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WuCelimuge
en-aut-sei=Wu
en-aut-mei=Celimuge
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=JiYusheng
en-aut-sei=Ji
en-aut-mei=Yusheng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YokohiraTokumi
en-aut-sei=Yokohira
en-aut-mei=Tokumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MuraseTutomu
en-aut-sei=Murase
en-aut-mei=Tutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Okayama University
kn-affil=

affil-num=2
en-affil=Okayama University
kn-affil=

affil-num=3
en-affil=Nagoya University
kn-affil=

affil-num=4
en-affil=Okayama University
kn-affil=

affil-num=5
en-affil=The Univ. of Electro-Commun.
kn-affil=

affil-num=6
en-affil=National Institute of Informatics
kn-affil=

affil-num=7
en-affil=Okayama University
kn-affil=

affil-num=8
en-affil=Nagoya University
kn-affil=
en-keyword=Multi-stage information processing system
kn-keyword=Multi-stage information processing system
en-keyword=VM migration control
kn-keyword=VM migration control
en-keyword=Deep reinforcement learning
kn-keyword=Deep reinforcement learning
en-keyword=Deep Deterministic Policy Gradient (DDPG)
kn-keyword=Deep Deterministic Policy Gradient (DDPG)
END

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dt-received=
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dt-accepted=
dt-pub-year=2024
dt-pub=20240325
dt-online=
en-article=
kn-article=
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kn-subject=
en-title=
kn-title=˜_‘ˆ–â‘èŠw�K‚É‚¨‚¯‚鋳Žt‚Ì–ðŠ„‚ÉŠÖ‚·‚錤‹†�|‹³Žt‚ÌŒ©‰ð•\–¾‚ÉŠÖ‚í‚é”»’f‚â‰e‹¿‚É’…–Ú‚µ‚Ä�|
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en-aut-name=IWASAKIKeisuke
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en-aut-mei=Keisuke
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affil-num=1
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È
END

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en-aut-name=ONOHiroko
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affil-num=1
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È
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affil-num=1
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
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affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŠÂ‹«�¶–½‰ÈŠwŒ¤‹†‰È
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kn-title=—V—£N-ƒOƒŠƒJƒ“‚Ì�¶—�‹@”\‰ð�Í‚ð–Ú“I‚Æ‚µ‚½ƒGƒ“ƒh-ƒÀ-N-ƒAƒZƒ`ƒ‹ƒOƒ‹ƒRƒTƒ~ƒjƒ_�[ƒ[ (ENGase) Œ‡‘¹ƒgƒ}ƒg‚Ì�\’z‚Æ�A•¨ENGase‚Ì“œ“]ˆÚŠˆ�«‚ÉŠÖ‚·‚錤‹†
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en-aut-name=OKAMOTONaoko
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ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŠÂ‹«�¶–½‰ÈŠwŒ¤‹†‰È
END

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END

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kn-title=IGFBP5‚É‚æ‚é”j�œ�×–E•ª‰»‚¨‚æ‚Ñ�œ‹zŽûƒ�ƒJƒjƒYƒ€‚̉ð–¾
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affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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en-aut-name=SAITOGo
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affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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kn-title=ƒŒƒWƒ“ƒZƒ�ƒ“ƒg�Ú’…‚É‚¨‚¯‚郌ƒWƒ“ƒR�[ƒeƒBƒ“ƒO‚ª�Ú’…‹y‚Ñ•Ó‰�˜R‰k‚É‹y‚Ú‚·‰e‹¿‚ɂ‚¢‚Ä
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en-aut-name=IUCHIYujin
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affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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en-title=Œû�o�G•½�ã”çŠà‚É‚¨‚¯‚éèò•”ƒŠƒ“ƒp�ß“]ˆÚ‚Æ�Ä”­‚Ì‘½Šp“I—\‘ª
kn-title=Multimodal Prediction of Cervical Lymph Node Metastasis and Recurrence in Oral Squamous Cell Carcinoma
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en-aut-name=KANEMOTOHideka
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affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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END

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en-title=CRISPR/dCas13‚ð‰î‚µ‚½RNA–Ɖu’¾�~‚É‚æ‚èSARS-CoV-2 5�fUTR RNA‚ƃqƒgŽ‰Ž¿‘ãŽÓŒo˜H‚Æ‚Ì‘ŠŒÝ�ì—p‚ª–¾‚ç‚©‚Æ‚È‚é
kn-title=An RNA-immunoprecipitation via CRISPR/dCas13 reveals an interaction between the SARS-CoV-2 5'UTR RNA and the process of human lipid metabolism
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en-aut-name=SHIMIZUYurika
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affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘��‡Œ¤‹†‰È
END

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dt-received=
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en-title=ˆê”N–ÚŒ¤�Cˆã‚ɑ΂·‚éƒVƒ~ƒ…ƒŒ�[ƒVƒ‡ƒ“‹³ˆç‚ƃsƒA�Eƒ‰�[ƒjƒ“ƒO–@‚Ì‘g‚Ý�‡‚킹‚ª—Õ�°‹Æ–±�¬�Ñ‚É—^‚¦‚éŒø‰Ê‚ɂ‚¢‚Ä�F ƒP�[ƒXƒRƒ“ƒgƒ��[ƒ‹Œ¤‹†‚Å‚ÌŒŸ“¢
kn-title=The effectiveness of simulation-based education combined with peer-assisted learning on clinical performance of first-year medical residents: a case-control study
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kn-subtitle=
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en-aut-name=MURAKAMITaku
en-aut-sei=MURAKAMI
en-aut-mei=Taku
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kn-aut-mei=‘ñ
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘��‡Œ¤‹†‰È
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=4
article-no=
start-page=746
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240407
dt-online=
en-article=
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kn-subject=
en-title=
kn-title=Pyrene-Modified Cyclic Peptides Detect Cu2+ Ions by Fluorescence in Water
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The detection of metal ions is an option for maintaining water quality and diagnosing metal ion-related diseases. In this study, we successfully detected metal ions using fluorescent peptides in water. First, we prepared seven linear (L1-L7) and seven cyclic (C1-C7) peptides containing two pyrenyl (Pyr) units and assessed the response to various metal ions by fluorescence. The results indicated that C1, which contains a hexameric cyclic peptide moiety consisting of Pyr and Gly units, did not show a fluorescent response to metal ions, while the linear L1 corresponding to C1 showed a response to Cu2+, but its selectivity was found to be poor through a competition assay for each metal ion. We then assessed C2-C7 and L2-L7, in which Gly was replaced by His units at various positions in the same manner. The results showed that C2-C7 responded to Cu2+ in a manner dependent on the His position. Additionally, superior selectivity was observed in C7 through a competition assay. These results demonstrate that the structural restriction of peptides and the sequence affect the selective detection of Cu2+ and reveal that peptides with an appropriate structure can accomplish the fluorescent detection of Cu2+ specifically.
en-copyright=
kn-copyright=

en-aut-name=MaekawaYuhi
en-aut-sei=Maekawa
en-aut-mei=Yuhi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SakuraSora
en-aut-sei=Sakura
en-aut-mei=Sora
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FurutaniYuji
en-aut-sei=Furutani
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FujiharaRento
en-aut-sei=Fujihara
en-aut-mei=Rento
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SugimeHisashi
en-aut-sei=Sugime
en-aut-mei=Hisashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OhtsukiTakashi
en-aut-sei=Ohtsuki
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KitamatsuMizuki
en-aut-sei=Kitamatsu
en-aut-mei=Mizuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry, Faculty of Science and Engineering, Kindai University
kn-affil=

affil-num=2
en-affil=Department of Applied Chemistry, Faculty of Science and Engineering, Kindai University
kn-affil=

affil-num=3
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Applied Chemistry, Faculty of Science and Engineering, Kindai University
kn-affil=

affil-num=5
en-affil=Department of Applied Chemistry, Faculty of Science and Engineering, Kindai University
kn-affil=

affil-num=6
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Applied Chemistry, Faculty of Science and Engineering, Kindai University
kn-affil=
en-keyword=peptide
kn-keyword=peptide
en-keyword=pyrene
kn-keyword=pyrene
en-keyword=metal ion
kn-keyword=metal ion
en-keyword=fluorescence
kn-keyword=fluorescence
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=4
article-no=
start-page=431
end-page=447
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230304
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Novel extracellular role of REIC/Dkk-3 protein in PD-L1 regulation in cancer cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The adenovirus-REIC/Dkk-3 expression vector (Ad-REIC) has been the focus of numerous clinical studies due to its potential for the quenching of cancers. The cancer-suppressing mechanisms of the REIC/DKK-3 gene depend on multiple pathways that exert both direct and indirect effects on cancers. The direct effect is triggered by REIC/Dkk-3-mediated ER stress that causes cancer-selective apoptosis, and the indirect effect can be classified in two ways: (i) induction, by Ad-REIC-mis-infected cancer-associated fibroblasts, of the production of IL-7, an important activator of T cells and NK cells, and (ii) promotion, by the secretory REIC/Dkk-3 protein, of dendritic cell polarization from monocytes. These unique features allow Ad-REIC to exert effective and selective cancer-preventative effects in the manner of an anticancer vaccine. However, the question of how the REIC/Dkk-3 protein leverages anticancer immunity has remained to be answered. We herein report a novel function of the extracellular REIC/Dkk-3?namely, regulation of an immune checkpoint via modulation of PD-L1 on the cancer-cell surface. First, we identified novel interactions of REIC/Dkk-3 with the membrane proteins C5aR, CXCR2, CXCR6, and CMTM6. These proteins all functioned to stabilize PD-L1 on the cell surface. Due to the dominant expression of CMTM6 among the proteins in cancer cells, we next focused on CMTM6 and observed that REIC/Dkk-3 competed with CMTM6 for PD-L1, thereby liberating PD-L1 from its complexation with CMTM6. The released PD-L1 immediately underwent endocytosis-mediated degradation. These results will enhance our understanding of not only the physiological nature of the extracellular REIC/Dkk-3 protein but also the Ad-REIC-mediated anticancer effects.
en-copyright=
kn-copyright=

en-aut-name=GoharaYuma
en-aut-sei=Gohara
en-aut-mei=Yuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TomonobuNahoko
en-aut-sei=Tomonobu
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KinoshitaRie
en-aut-sei=Kinoshita
en-aut-mei=Rie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FutamiJunichiro
en-aut-sei=Futami
en-aut-mei=Junichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AudebertL?na
en-aut-sei=Audebert
en-aut-mei=L?na
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ChenYouyi
en-aut-sei=Chen
en-aut-mei=Youyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KomalasariNi Luh Gede Yoni
en-aut-sei=Komalasari
en-aut-mei=Ni Luh Gede Yoni
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=JiangFan
en-aut-sei=Jiang
en-aut-mei=Fan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YoshizawaChikako
en-aut-sei=Yoshizawa
en-aut-mei=Chikako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=YamamotoKen-ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=WatanabeMasami
en-aut-sei=Watanabe
en-aut-mei=Masami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KumonHiromi
en-aut-sei=Kumon
en-aut-mei=Hiromi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=4
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=7
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=9
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=10
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=11
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=12
en-affil=Department of Urology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=13
en-affil=Innovation Center Okayama for Nanobio-Targeted Therapy, Okayama University
kn-affil=

affil-num=14
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=
en-keyword=Breast cancer
kn-keyword=Breast cancer
en-keyword=REIC/Dkk-3
kn-keyword=REIC/Dkk-3
en-keyword=PD-L1
kn-keyword=PD-L1
en-keyword=Immune checkpoint
kn-keyword=Immune checkpoint
en-keyword=Cancer therapy
kn-keyword=Cancer therapy
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=4
article-no=
start-page=497
end-page=505
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230915
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Investigation of uncertainty in internal target volume definition for lung stereotactic body radiotherapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study evaluated the validity of internal target volumes (ITVs) defined by three- (3DCT) and four-dimensional computed tomography (4DCT), and subsequently compared them with actual movements during treatment. Five patients with upper lobe lung tumors were treated with stereotactic body radiotherapy (SBRT) at 48 Gy in four fractions. Planning 3DCT images were acquired with peak-exhale and peak-inhale breath-holds, and 4DCT images were acquired in the cine mode under free breathing. Cine images were acquired using an electronic portal imaging device during irradiation. Tumor coverage was evaluated based on the manner in which the peak-to-peak breathing amplitude on the planning CT covered the range of tumor motion (�}?3 SD) during irradiation in the left?right, anteroposterior, and cranio-caudal (CC) directions. The mean tumor coverage of the 4DCT-based ITV was better than that of the 3DCT-based ITV in the CC direction. The internal margin should be considered when setting the irradiation field for 4DCT. The proposed 4DCT-based ITV can be used as an efficient approach in free-breathing SBRT for upper-lobe tumors of the lung because its coverage is superior to that of 3DCT.
en-copyright=
kn-copyright=

en-aut-name=NakanishiDaiki
en-aut-sei=Nakanishi
en-aut-mei=Daiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OitaMasataka
en-aut-sei=Oita
en-aut-mei=Masataka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FukunagaJun-Ichi
en-aut-sei=Fukunaga
en-aut-mei=Jun-Ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
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ORCID=

en-aut-name=HiroseTaka-Aki
en-aut-sei=Hirose
en-aut-mei=Taka-Aki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YoshitakeTadamasa
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kn-aut-mei=
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ORCID=

en-aut-name=SasakiMotoharu
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en-aut-mei=Motoharu
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Division of Radiology, Department of Medical Technology, Kyushu University Hospital
kn-affil=

affil-num=4
en-affil=Division of Radiology, Department of Medical Technology, Kyushu University Hospital
kn-affil=

affil-num=5
en-affil=Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
kn-affil=

affil-num=6
en-affil=Graduate School of Biomedical Sciences, Tokushima University
kn-affil=
en-keyword=4DCT
kn-keyword=4DCT
en-keyword=3DCT
kn-keyword=3DCT
en-keyword=Internal target volume
kn-keyword=Internal target volume
en-keyword=EPID imaging
kn-keyword=EPID imaging
en-keyword=Stereotactic body radiotherapy
kn-keyword=Stereotactic body radiotherapy
en-keyword=Lung cancer
kn-keyword=Lung cancer
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=3
article-no=
start-page=243
end-page=253
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=GSK-3ƒ¿/ƒÀ and MEK inhibitors assist the microenvironment of tumor initiation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Induced pluripotent stem cells (iPSCs) are useful tools for modeling diseases and developing personalized medicine. We have been developing cancer stem cells (CSCs) from iPSCs with conditioned medium (CM) of cancer-derived cells as the mimicry of the microenvironment of tumor initiation. However, the conversion of human iPSCs has not always been efficient with only CM. In this study, human iPSCs reprogrammed from monocytes of healthy volunteers were cultured in a media containing 50% of the CM from human pancreatic cancer derived BxPC3 cells supplemented with a MEK inhibitor (AZD6244) and a GSK-3ƒ¿/ƒÀ inhibitor (CHIR99021). The survived cells were assessed for the characteristics of CSCs in vitro and in vivo. As a result, they exhibited CSC phenotypes of self-renewal, differentiation, and malignant tumorigenicity. Primary culture of the malignant tumors of the converted cells exhibited the elevated expression of CSC related genes CD44, CD24 and EPCAM maintaining the expression of stemness genes. In conclusion, the inhibition of GSK-3ƒ¿/ƒÀ and MEK and the microenvironment of tumor initiation mimicked by the CM can convert human normal stem cells into CSCs. This study could provide insights into establishing potentially novel personalized cancer models which could help investigate the tumor initiation and screening of personalized therapies on CSCs.
en-copyright=
kn-copyright=

en-aut-name=HassanGhmkin
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en-aut-mei=Ghmkin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
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ORCID=

en-aut-name=AfifySaid M.
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kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ZahraMaram H.
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aut-affil-num=3
ORCID=

en-aut-name=NawaraHend M.
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aut-affil-num=4
ORCID=

en-aut-name=KumonKazuki
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ORCID=

en-aut-name=IwasakiYoshiaki
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en-aut-mei=Yoshiaki
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aut-affil-num=6
ORCID=

en-aut-name=SalomonDavid S.
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en-aut-mei=David S.
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SenoAkimasa
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ORCID=

en-aut-name=SenoMasaharu
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kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Cancer Stem Cell Engineering, Faculty of Interdisciplinary Science and Engineering in Health Systems, Institute of Academic and Research, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Cancer Stem Cell Engineering, Faculty of Interdisciplinary Science and Engineering in Health Systems, Institute of Academic and Research, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Cancer Stem Cell Engineering, Faculty of Interdisciplinary Science and Engineering in Health Systems, Institute of Academic and Research, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Cancer Stem Cell Engineering, Faculty of Interdisciplinary Science and Engineering in Health Systems, Institute of Academic and Research, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Cancer Stem Cell Engineering, Faculty of Interdisciplinary Science and Engineering in Health Systems, Institute of Academic and Research, Okayama University
kn-affil=

affil-num=6
en-affil=Health Service Center, Okayama University
kn-affil=

affil-num=7
en-affil=Center for Cancer Research, National Cancer Institute
kn-affil=

affil-num=8
en-affil=Department of Cancer Stem Cell Engineering, Faculty of Interdisciplinary Science and Engineering in Health Systems, Institute of Academic and Research, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Cancer Stem Cell Engineering, Faculty of Interdisciplinary Science and Engineering in Health Systems, Institute of Academic and Research, Okayama University
kn-affil=
en-keyword=Cancer stem cells
kn-keyword=Cancer stem cells
en-keyword=Human iPSCs
kn-keyword=Human iPSCs
en-keyword=Signal pathway inhibitors
kn-keyword=Signal pathway inhibitors
en-keyword=Tumor initiation
kn-keyword=Tumor initiation
END

start-ver=1.4
cd-journal=joma
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dt-received=
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dt-pub-year=2024
dt-pub=20240331
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kn-title=— •\Ž†�E‰p•¶–ÚŽŸ
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END

start-ver=1.4
cd-journal=joma
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END

start-ver=1.4
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en-title=Practical BIZEN Device Design Course Activity Report in Fiscal 2023
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affil-num=3
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affil-num=5
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affil-num=6
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affil-num=7
en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University
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en-title=Advanced Hospital Training Activities in Fiscal 2023
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en-aut-name=MORITAMizuki
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affil-num=1
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affil-num=2
en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University
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affil-num=3
en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“��‡‰ÈŠwŠwˆæ

affil-num=4
en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University
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affil-num=5
en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University
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affil-num=6
en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“��‡‰ÈŠwŠwˆæ

affil-num=7
en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“��‡‰ÈŠwŠwˆæ

affil-num=8
en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“��‡‰ÈŠwŠwˆæ
END

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en-title=Report: International Symposium organized by Graduate school of interdisciplinary science and engineering in health systems
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affil-num=2
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affil-num=3
en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University
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affil-num=4
en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University
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en-title=A Review of Medical Futility Debate
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affil-num=1
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en-title=Descriptive Study of Itching Experienced by Adults with Atopic Dermatitis
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kn-subtitle=
en-abstract=
kn-abstract=Background: Atopic Dermatitis (AD) is a chronic inflammatory skin disease characterized by intense itching, significantly impacting patients' psychosocial well-being worldwide. Objective: This study aimed to elucidate the multifaceted and multilayered burden of itch in adult AD patients, exploring strategies to capture the complexity of the disease and its symptoms comprehensively. Methods: The study utilized an array of Patient Reported Outcome (PRO) measures and conducted an exploratory analysis of patients' subjective descriptions of their itch experiences. Results: Twenty-three participants (female: n=16) were enrolled in the study. The Analyses revealed that none of the participants experienced in the same way about physical, emotional, and psychological burden of itch and limitation in social life. Additionally, it was found that PROs capture only partial aspects of itch and do not provide a comprehensive understanding. Discussion: The findings highlight the necessity of employing multiple PROs and conducting in-depth patient interviews to understand the daily life challenges associated with itch. The potential of interdisciplinary research to address the complex burden of itch in AD patients is also emphasized. Conclusion: A comprehensive understanding of the symptom of itch in AD patients requires the use of multiple PROs.
en-copyright=
kn-copyright=

en-aut-name=HIRAMIYuki
en-aut-sei=HIRAMI
en-aut-mei=Yuki
kn-aut-name=•½Œ©—LŠó
kn-aut-sei=•½Œ©
kn-aut-mei=—LŠó
aut-affil-num=1
ORCID=

en-aut-name=FUJIMOTOKanako
en-aut-sei=FUJIMOTO
en-aut-mei=Kanako
kn-aut-name=“¡–{—vŽq
kn-aut-sei=“¡–{
kn-aut-mei=—vŽq
aut-affil-num=2
ORCID=

en-aut-name=KODAMasahide
en-aut-sei=KODA
en-aut-mei=Masahide
kn-aut-name=��“c�«‰p
kn-aut-sei=��“c
kn-aut-mei=�«‰p
aut-affil-num=3
ORCID=

en-aut-name=HARADANahoko
en-aut-sei=HARADA
en-aut-mei=Nahoko
kn-aut-name=Œ´“c“Þ•äŽq
kn-aut-sei=Œ´“c
kn-aut-mei=“Þ•äŽq
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Faculty of Health Sciences, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@•ÛŒ’Šwˆæ

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“��‡‰ÈŠwŒ¤‹†‰È

affil-num=3
en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@ˆãŽ•–òŠwˆæ

affil-num=4
en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“��‡‰ÈŠwŠwˆæ
en-keyword=Atopic dermatitis
kn-keyword=Atopic dermatitis
en-keyword=Adults
kn-keyword=Adults
en-keyword=descriptive study
kn-keyword=descriptive study
en-keyword=itching
kn-keyword=itching
en-keyword=patient experience
kn-keyword=patient experience
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=1
end-page=17
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Interdisciplinary Science Contributing to Sustainable Development of Human Society
kn-title=?—ގЉï‚ÌŽ�‘±“I”­“W‚É�vŒ£‚·‚é“��‡‰ÈŠw
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With the increase of the complexity of human society because of the globalization and the advancement of each scientific field, innovations by effective collaborations of experts in various fields become necessary to solve problems in human society and to increase the findings of each field. From the backgrounds, the interdisciplinary science b ecomes popular in recent y ears. This article p resents the approach of interdisciplinary science and its importance to the sustainable development of human society. As an example of studies by interdisciplinary science, this article introduces a virtual reality based mirror visual feedback therapy system that the author has been developed in collaboration with medical doctors, professors in engineering field and students of the author�fs laboratory in Okayama University.
en-copyright=
kn-copyright=

en-aut-name=GOFUKUAkio
en-aut-sei=GOFUKU
en-aut-mei=Akio
kn-aut-name=ŒÜ•Ÿ–¾•v
kn-aut-sei=ŒÜ•Ÿ
kn-aut-mei=–¾•v
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Okayama University
kn-affil=‰ªŽR‘åŠw
en-keyword=Interdisciplinary science
kn-keyword=Interdisciplinary science
en-keyword=Collaboration of medicine and engineering
kn-keyword=Collaboration of medicine and engineering
en-keyword=Virtual reality
kn-keyword=Virtual reality
en-keyword=Mirror visual feedback therapy system
kn-keyword=Mirror visual feedback therapy system
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=•\Ž†�E–ÚŽŸ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=1
article-no=
start-page=6723
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240320
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Development of a novel AAK1 inhibitor via Kinobeads-based screening
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A chemical proteomics approach using Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) inhibitor-immobilized sepharose (TIM-063-Kinobeads) identified main targets such as CaMKK alpha/1 and beta/2, and potential off-target kinases, including AP2-associated protein kinase 1 (AAK1), as TIM-063 interactants. Because TIM-063 interacted with the AAK1 catalytic domain and inhibited its enzymatic activity moderately (IC50 = 8.51 mu M), we attempted to identify potential AAK1 inhibitors from TIM-063-derivatives and found a novel AAK1 inhibitor, TIM-098a (11-amino-2-hydroxy-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one) which is more potent (IC50 = 0.24 mu M) than TIM-063 without any inhibitory activity against CaMKK isoforms and a relative AAK1-selectivity among the Numb-associated kinases family. TIM-098a could inhibit AAK1 activity in transfected cultured cells (IC50 = 0.87 mu M), indicating cell-membrane permeability of the compound. Overexpression of AAK1 in HeLa cells significantly reduced the number of early endosomes, which was blocked by treatment with 10 mu M TIM-098a. These results indicate TIM-063-Kinobeads-based chemical proteomics is efficient for identifying off-target kinases and re-evaluating the kinase inhibitor (TIM-063), leading to the successful development of a novel inhibitory compound (TIM-098a) for AAK1, which could be a molecular probe for AAK1. TIM-098a may be a promising lead compound for a more potent, selective and therapeutically useful AAK1 inhibitor.
en-copyright=
kn-copyright=

en-aut-name=YoshidaAkari
en-aut-sei=Yoshida
en-aut-mei=Akari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhtsukaSatomi
en-aut-sei=Ohtsuka
en-aut-mei=Satomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MatsumotoFumiya
en-aut-sei=Matsumoto
en-aut-mei=Fumiya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MiyagawaTomoyuki
en-aut-sei=Miyagawa
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OkinoRei
en-aut-sei=Okino
en-aut-mei=Rei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IkedaYumeya
en-aut-sei=Ikeda
en-aut-mei=Yumeya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TadaNatsume
en-aut-sei=Tada
en-aut-mei=Natsume
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=GotohAkira
en-aut-sei=Gotoh
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MagariMasaki
en-aut-sei=Magari
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=HatanoNaoya
en-aut-sei=Hatano
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=MorishitaRyo
en-aut-sei=Morishita
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=SatohAyano
en-aut-sei=Satoh
en-aut-mei=Ayano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=SunatsukiYukinari
en-aut-sei=Sunatsuki
en-aut-mei=Yukinari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=NilssonUlf J.
en-aut-sei=Nilsson
en-aut-mei=Ulf J.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=IshikawaTeruhiko
en-aut-sei=Ishikawa
en-aut-mei=Teruhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=TokumitsuHiroshi
en-aut-sei=Tokumitsu
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

affil-num=1
en-affil=Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Science Education, Graduate School of Education, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Science Education, Graduate School of Education, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Science Education, Graduate School of Education, Okayama University
kn-affil=

affil-num=6
en-affil=Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=7
en-affil=Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=8
en-affil=Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=9
en-affil=Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=10
en-affil=Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=11
en-affil=CellFree Sciences Co. Ltd
kn-affil=

affil-num=12
en-affil=Organelle Systems Biotechnology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=13
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=14
en-affil=Department of Chemistry, Lund University
kn-affil=

affil-num=15
en-affil=Department of Science Education, Graduate School of Education, Okayama University
kn-affil=

affil-num=16
en-affil=Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=1371342
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240326
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Our earlier research revealed that the secreted lysyl oxidase-like 4 (LOXL4) that is highly elevated in triple-negative breast cancer (TNBC) acts as a catalyst to lock annexin A2 on the cell membrane surface, which accelerates invasive outgrowth of the cancer through the binding of integrin-ƒÀ1 on the cell surface. However, whether this machinery is subject to the LOXL4-mediated intrusive regulation remains uncertain.<br>
<br>
Methods: Cell invasion was assessed using a transwell-based assay, protein?protein interactions by an immunoprecipitation?Western blotting technique and immunocytochemistry, and plasmin activity in the cell membrane by gelatin zymography.<br>
<br>
Results: We revealed that cell surface annexin A2 acts as a receptor of plasminogen via interaction with S100A10, a key cell surface annexin A2-binding factor, and S100A11. We found that the cell surface annexin A2/S100A11 complex leads to mature active plasmin from bound plasminogen, which actively stimulates gelatin digestion, followed by increased invasion.<br>
<br>
Conclusion: We have refined our understanding of the role of LOXL4 in TNBC cell invasion: namely, LOXL4 mediates the upregulation of annexin A2 at the cell surface, the upregulated annexin 2 binds S100A11 and S100A10, and the resulting annexin A2/S100A11 complex acts as a receptor of plasminogen, readily converting it into active-form plasmin and thereby enhancing invasion.
en-copyright=
kn-copyright=

en-aut-name=TakahashiTetta
en-aut-sei=Takahashi
en-aut-mei=Tetta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TomonobuNahoko
en-aut-sei=Tomonobu
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KinoshitaRie
en-aut-sei=Kinoshita
en-aut-mei=Rie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YamamotoKen-Ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-Ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KomalasariNi Luh Gede Yoni
en-aut-sei=Komalasari
en-aut-mei=Ni Luh Gede Yoni
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ChenYouyi
en-aut-sei=Chen
en-aut-mei=Youyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=JiangFan
en-aut-sei=Jiang
en-aut-mei=Fan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=GoharaYuma
en-aut-sei=Gohara
en-aut-mei=Yuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OchiToshiki
en-aut-sei=Ochi
en-aut-mei=Toshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=RumaI. Made Winarsa
en-aut-sei=Ruma
en-aut-mei=I. Made Winarsa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=SumardikaI. Wayan
en-aut-sei=Sumardika
en-aut-mei=I. Wayan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=ZhouJin
en-aut-sei=Zhou
en-aut-mei=Jin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=HonjoTomoko
en-aut-sei=Honjo
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=SakaguchiYoshihiko
en-aut-sei=Sakaguchi
en-aut-mei=Yoshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=YamauchiAkira
en-aut-sei=Yamauchi
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=KuribayashiFutoshi
en-aut-sei=Kuribayashi
en-aut-mei=Futoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=KondoEisaku
en-aut-sei=Kondo
en-aut-mei=Eisaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=InoueYusuke
en-aut-sei=Inoue
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=FutamiJunichiro
en-aut-sei=Futami
en-aut-mei=Junichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=ZamamiYoshito
en-aut-sei=Zamami
en-aut-mei=Yoshito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=7
en-affil=Department of Breast Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=12
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=13
en-affil=Medical Oncology Department of Gastrointestinal Tumors, Liaoning Cancer Hospital & Institute, Cancer Hospital of the Dalian University of Technology
kn-affil=

affil-num=14
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=15
en-affil=Department of Microbiology, Tokushima Bunri University
kn-affil=

affil-num=16
en-affil=Department of Biochemistry, Kawasaki Medical School
kn-affil=

affil-num=17
en-affil=Department of Biochemistry, Kawasaki Medical School
kn-affil=

affil-num=18
en-affil=Division of Tumor Pathology, Near InfraRed Photo-Immuno-Therapy Research Institute, Kansai Medical University
kn-affil=

affil-num=19
en-affil=Faculty of Science and Technology, Division of Molecular Science, Gunma University
kn-affil=

affil-num=20
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=21
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=22
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=23
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=breast cancer
kn-keyword=breast cancer
en-keyword=lysyl oxidase
kn-keyword=lysyl oxidase
en-keyword=annexin A2
kn-keyword=annexin A2
en-keyword=S100A11
kn-keyword=S100A11
en-keyword=plasmin
kn-keyword=plasmin
en-keyword=cancer microenvironment
kn-keyword=cancer microenvironment
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=6
article-no=
start-page=1783
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240320
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Enhancing Diagnostic Precision: Evaluation of Preprocessing Filters in Simple Diffusion Kurtosis Imaging for Head and Neck Tumors
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Our initial clinical study using simple diffusion kurtosis imaging (SDI), which simultaneously produces a diffusion kurtosis image (DKI) and an apparent diffusion coefficient map, confirmed the usefulness of SDI for tumor diagnosis. However, the obtained DKI had noticeable variability in the mean kurtosis (MK) values, which is inherent to SDI. We aimed to improve this variability in SDI by preprocessing with three different filters (Gaussian [G], median [M], and nonlocal mean) of the diffusion-weighted images used for SDI. Methods: The usefulness of filter parameters for diagnosis was examined in basic and clinical studies involving 13 patients with head and neck tumors. Results: The filter parameters, which did not change the median MK value, but reduced the variability and significantly homogenized the MK values in tumor and normal tissues in both basic and clinical studies, were identified. In the receiver operating characteristic curve analysis for distinguishing tumors from normal tissues using MK values, the area under curve values significantly improved from 0.627 without filters to 0.641 with G (sigma = 0.5) and 0.638 with M (radius = 0.5). Conclusions: Thus, image pretreatment with G and M for SDI was shown to be useful for improving tumor diagnosis in clinical practice.
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en-aut-name=Al-HammadWlla E.
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en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
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affil-num=2
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
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affil-num=3
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
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affil-num=7
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
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affil-num=11
en-affil=Graduate School of Interdisciplinary Sciences and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=12
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=13
en-affil=Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=14
en-affil=Department of Oral Radiology, Faculty of Dentistry, Hasanuddin University
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affil-num=15
en-affil=Department of Dentistry and Dental Surgery, College of Medicine and Health Sciences, An-Najah National University
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affil-num=16
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
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affil-num=17
en-affil=Department of Oral and Maxillofacial Radiology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
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en-keyword=diffusion-weighted image
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en-keyword=Gaussian filter
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en-keyword=phantom
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en-keyword=simple diffusion kurtosis imaging
kn-keyword=simple diffusion kurtosis imaging
en-keyword=restricted diffusion-weighted image
kn-keyword=restricted diffusion-weighted image
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en-abstract=Autism Spectrum Disorder�iASD�j, Attention Deficit Hyperactivity Disorder�iADHD�j, and Learning Disabilities�iLD�j are obscure for infants to understand, but picture books about these disabilities have recently increased, and are considered to be educational materials to understand these disabilities from early childhood. Picture books, that can clearly present disabilities and their characteristic behaviors through stories, offer various choices and support an understanding of disabilities in the real childcare. Also, many picture books for understanding disabilities describe the emotions of the family and can be used to deepen infants' understanding of their parents and siblings. On the other hand, the number of picture books about the environment and its improvement is small. An increase in the number of picture books on these topics is expected, and handmade picture book materials based on the real conditions w ould also be effective.
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affil-num=1
en-affil=MINAN Certified Centers for Early Childhood Education and Care
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en-affil=Department of Early Childhood Education and Care�CKurashiki City College
kn-affil=‘q•~Žs—§’ZŠú‘åŠw•ÛˆçŠw‰È

affil-num=3
en-affil=Faculty of Childhood Education, Kurashiki Sakuyo University
kn-affil=‚­‚炵‚«�ì—z‘åŠwŽq‚Ç‚à‹³ˆçŠw•”

affil-num=4
en-affil=Faculty of Education, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@‹³ˆçŠwˆæ
en-keyword=—cŽ™Šú (Early Childhood)
kn-keyword=—cŽ™Šú (Early Childhood)
en-keyword=Ž©•ÂƒXƒyƒNƒgƒ‰ƒ€�Ç (Autism Spectrum Disorder�iASD�j)
kn-keyword=Ž©•ÂƒXƒyƒNƒgƒ‰ƒ€�Ç (Autism Spectrum Disorder�iASD�j)
en-keyword=’�ˆÓŒ‡”@‘½“®�Ç (Attention Deficit Hyperactivity Disorder�iADHD�j)
kn-keyword=’�ˆÓŒ‡”@‘½“®�Ç (Attention Deficit Hyperactivity Disorder�iADHD�j)
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start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=325
end-page=339
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240329
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Development and Potential of the Reggio Emilia Approach to Education in Japan �\Aspects of the Acceptance and Introduction Phases and Challenges in the Practical Application Phase�\
kn-title=“ú–{‚É‚¨‚¯‚郌ƒbƒWƒ‡�EƒGƒ~ƒŠƒA‹³ˆç‚Ì“WŠJ‚Ɖ”\�« �\Žó—e�E“±“üŠú‚Ì—l‘Š‚ÆŽÀ‘HŠú‚̉ۑè�\
en-subtitle=
kn-subtitle=
en-abstract=�@As the Reggio Emilia approach is transitioning from the period of acceptance and introduction to the period of practical application in Japan, this paper discusses the issues and challenges that need to be addressed to gain a more profound and accurate understanding of this educational approach. First, it is necessary to accurately grasp the formative and educational principles behind the artistic development of children in the city of Reggio Emilia. Second, there is a need to create a system for training �gatelieristas�h who can study the foundations of early childhood education, research children�fs formative expressions, and engage in art production and appreciation. Third, a fundamental shift in the philosophy of childcare is required, positioning �gproject�h as a higher-level concept over the Japanese childcare philosophy of �gplay = learning.�h Fourth, annual events must be carefully selected for childcare practices that value children�fs autonomy. Fifth, it is essential to examine whether �gdocumentation�h can replace the conventional Japanese way of recording childcare. 
kn-abstract=�@–{˜_‚Í�C“ú–{‚Ö‚ÌŽó—e�E“±“üŠú‚©‚çŽÀ‘HŠú‚ɈÚ�s‚µ‚‚‚ ‚郌ƒbƒWƒ‡�EƒGƒ~ƒŠƒA‹³ˆç‚ÉŠÖ‚µ‚Ä�³‚µ‚­—�‰ð‚ð�[‚߂邽‚ß‚É‚Í�C‰½‚ª–â‘è‚â‰Û‘è‚É‚È‚é‚©‚ɂ‚¢‚Ä�lŽ@‚·‚é�B‘æ‚P‚É�CƒŒƒbƒWƒ‡�EƒGƒ~ƒŠƒAŽs‚ÌŽq‚Ç‚à‚Ì‘¢Œ`Œ|�p‚Ì”wŒi‚É‚ ‚é‘¢Œ`Œ´—�‚⋳ˆçŒ´—�‚ð�³‚µ‚­”cˆ¬‚·‚é•K—v‚ª‚ ‚é�B‘æ‚Q‚É�C—cŽ™‹³ˆç‚ðŠî‘b‚©‚çŠw‚Ñ�CŽq‚Ç‚à‚Ì‘¢Œ`•\Œ»‚ðŒ¤‹†‚µ�C”ü�p�§�ì‚ÆŠÓ�Ü‚É�]Ž–‚Å‚«‚é�uƒAƒgƒŠƒGƒŠƒXƒ^�v—{�¬‚ÌŽd‘g‚Ý�ì‚肪—v�¿‚³‚ê‚é�B‘æ‚R‚É�C“ú–{‚Ì•Ûˆç—�”O‚Å‚ ‚é�u—V‚Ñ��Šw‚Ñ�v‚Ì�ãˆÊŠT”O‚Æ‚µ‚Ä�uƒvƒ�ƒWƒFƒNƒg�v‚ðˆÊ’u•t‚¯�C�ª–{“I‚È•Ûˆç—�”O‚Ì“]Š·‚ª‹�‚ß‚ç‚ê‚é�B‘æ‚S‚É�CŽq‚Ç‚à‚ÌŽå‘Ì�«‚ð‘å�Ø‚É‚µ‚½•ÛˆçŽÀ‘H‚Ì‚½‚ß‚É�C”NŠÔ�sŽ–‚ð�¸‘I‚µ‚È‚¯‚ê‚΂Ȃç‚È‚¢�B‘æ‚T‚É�C‚±‚ê‚Ü‚Å‚Ì“ú–{‚Ì•Ûˆç‹L˜^‚ÌŽd•û‚ð�uƒhƒLƒ…ƒ�ƒ“ƒe�[ƒVƒ‡ƒ“�v‚É‘ã‘Ö‚Å‚«‚é‚©‚Ç‚¤‚©‚ÌŒŸ“¢‚ª•s‰ÂŒ‡‚Å‚ ‚é�B
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en-aut-name=TAKAHASHIKei
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en-aut-name=ODAKumiko
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affil-num=1
en-affil=Faculty of Education, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@‹³ˆçŠwˆæ

affil-num=2
en-affil=Faculty of Childhood Education, Kurashiki Sakuyo University
kn-affil=‚­‚炵‚«�ì—z‘åŠwŽq‚Ç‚à‹³ˆçŠw•”

affil-num=3
en-affil=Faculty of Human Life Sciences, Notre Dame Seishin University
kn-affil=ƒm�[ƒgƒ‹ƒ_ƒ€�´�S�—Žq‘åŠw�lŠÔ�¶ŠˆŠw•”
en-keyword=ƒŒƒbƒWƒ‡�EƒGƒ~ƒŠƒA‹³ˆç (Reggio Emilia approach)
kn-keyword=ƒŒƒbƒWƒ‡�EƒGƒ~ƒŠƒA‹³ˆç (Reggio Emilia approach)
en-keyword=Œ|�p�«‚Ì—�‰ð (understanding artistry)
kn-keyword=Œ|�p�«‚Ì—�‰ð (understanding artistry)
en-keyword=ƒAƒgƒŠƒGƒŠƒXƒ^‚Ì—{�¬ (atelierista training)
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cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=309
end-page=323
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240329
dt-online=
en-article=
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en-subject=
kn-subject=
en-title=Trends and Issues in Research on the Reggio Emilia Approach
kn-title=ƒŒƒbƒWƒ‡�EƒGƒ~ƒŠƒA‹³ˆç‚ÌŒ¤‹†“®Œü‚Ɖۑè
en-subtitle=
kn-subtitle=
en-abstract=�@This study organizes the trends of research on the Reggio Emilia approach and elucidates the issues of practicing and researching this approach. As the first stage of this s tudy, previous studies, mainly those conducted in Japan, were comprehensively reviewed. As a result, it was found that substantial findings were obtained on research concerning projects, project-based preschool education, and creativity and expressive activities. At the same time, the uniformities and differences between the Reggio Emilia approach and the philosophies as well as methods of preschool education in Japan were elucidated. Further academic research must be conducted??which focuses on artistry, creativity, and cooperativeness (communality), the core of the Reggio Emilia approach, and their understanding??that produces findings discussing art education and children�fs expressions through freestyle arts and crafts.
kn-abstract=�@–{˜_‚Í�CƒŒƒbƒWƒ‡�EƒGƒ~ƒŠƒA‹³ˆç‚ÉŠÖ‚·‚錤‹†“®Œü‚ð�®—�‚µ�CŽÀ‘H‹y‚ÑŒ¤‹†�ã‚̉ۑè‚𖾂炩‚É‚·‚é‚à‚Ì‚Å‚ ‚é�BŒ¤‹†‚Ì‘æˆê’iŠK‚Æ‚µ‚Ä“ú–{�‘“à‚ÌŒ¤‹†‚ð’†�S‚É�æ�sŒ¤‹†‚ðŠTŠÏ‚µ‚½Œ‹‰Ê�C�uƒvƒ�ƒWƒFƒNƒg�v�uƒvƒ�ƒWƒFƒNƒgŒ^•Ûˆç�v�u‘n‘¢�«‚Æ•\Œ»Šˆ“®�v‚É‚©‚©‚í‚錤‹†�¬‰Ê‚ª�[ŽÀ‚µ‚Ä‚¢‚邱‚Æ‚ª”»–¾‚µ‚½�B‚»‚ê‚Æ“¯Žž‚É�C“ú–{‚Ì•Ûˆç—�”O‚â•Ûˆç•û–@‚Ƃ̈ê’v“_‚â‘Šˆá“_‚à–¾‚ç‚©‚É‚È‚Á‚½�B�¡Œã‚Í�CƒŒƒbƒWƒ‡�EƒGƒ~ƒŠƒA‹³ˆç‚Ì�ªŠ²‚ÆŒ¾‚í‚ê‚é�uŒ|�p�«�v�u‘n‘¢�«�v�u‹¦“¯�«�i‹¤“¯�«�j�v‚Æ‚»‚Ì—�‰ð‚ðŠw�pŒ¤‹†‚ÌŽå‘è‚É‚µ‚Ä�CŒ|�p‹³ˆç‚âŽq‚Ç‚à‚Ì‘¢Œ`•\Œ»‚ð�lŽ@‚µ‚½Œ¤‹†�¬‰Ê‚ª‘Ò‚¿–]‚Ü‚ê‚é�B
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en-aut-name=OKAYAMAMari
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en-aut-name=TAKAHASHIToshiyuki
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en-aut-mei=Toshiyuki
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kn-aut-mei=•q”V
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Faculty of Childhood Education, Kurashiki Sakuyo University
kn-affil=‚­‚炵‚«�ì—z‘åŠwŽq‚Ç‚à‹³ˆçŠw•”

affil-num=2
en-affil=Faculty of Human Sciences, Chikushi Jogakuen University
kn-affil=’}Ž‡�—Šw‰€‘åŠw�lŠÔ‰ÈŠw•”

affil-num=3
en-affil=Faculty of Education, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@‹³ˆçŠwˆæ
en-keyword=ƒŒƒbƒWƒ‡�EƒGƒ~ƒŠƒA‹³ˆç (the Reggio Emilia approach)
kn-keyword=ƒŒƒbƒWƒ‡�EƒGƒ~ƒŠƒA‹³ˆç (the Reggio Emilia approach)
en-keyword=ƒvƒ�ƒWƒFƒNƒg (projects)
kn-keyword=ƒvƒ�ƒWƒFƒNƒg (projects)
en-keyword=‘n‘¢�« (creativity)
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en-keyword=•\Œ»Šˆ“® (expressive activities)
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en-keyword=‰Û‘è (issues)
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END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=297
end-page=308
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240329
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Development of Japanese Language Materials to Support Tandem Learning: Focus on Task Types
kn-title=ƒ^ƒ“ƒfƒ€Šw�K‚ðŽx‰‡‚·‚é“ú–{Œê‹³�Þ‚ÌŠJ”­ �\ƒ^ƒXƒN�Eƒ^ƒCƒv‚É’…–Ú‚µ‚Ä�\
en-subtitle=
kn-subtitle=
en-abstract=This paper reports on the development and practical application of Japanese language teaching materials for tandem learning between Japanese and international students. In order to support autonomous cultural and language learning among Japanese native speakers who are not language teachers, task-based introductory intermediate-level learning materials focusing on meaning were developed. Specifically, the materials were arranged in the following order: (1) information exchange tasks, (2) comparison and analysis tasks, and (3) cooperative tasks, with the cognitive load and the amount of negotiation of meaning increasing step by step. Participants gave high marks to the structures and topics of these materials in the tandem learning practice. However, analysis of the participant interactions revealed that in the more difficult cooperative task, the level of understanding of the foreign students was low, and they were not fully involved in the decision-making process with their Japanese partner.
kn-abstract=�@–{�e‚Å‚Í�C“ú–{�lŠw�¶‚¨‚æ‚Ñ—¯Šw�¶ŠÔ‚̃^ƒ“ƒfƒ€Šw�K—p‚Ì“ú–{Œê‹³�Þ‚ÌŠJ”­‚¨‚æ‚Ñ‹³�Þ‚ð—p‚¢‚½ŽÀ‘H‚ɂ‚¢‚Ä•ñ��‚·‚é�BŒ¾Œê‹³Žt‚Å‚Í‚È‚¢•êŒê˜bŽÒ“¯Žm‚ÌŽ©—¥“I‚È•¶‰»‚¨‚æ‚ÑŒ¾Œê‚ÌŠw‚Ñ�‡‚¢‚ðŽx‰‡‚·‚邽‚ß�C�uˆÓ–¡�v‚É�Å“_‚ª“–‚½‚éƒ^ƒXƒNƒx�[ƒX‚Ì’†‹‰“ü–僌ƒxƒ‹‚Ì‹³�ÞŠJ”­‚ð�s‚Á‚½�B‹ï‘Ì“I‚É‚Í�C�i1�j�î•ñŒðŠ·ƒ^ƒXƒN�C�i2�j”äŠr�E•ª�̓^ƒXƒN�C�i3�j‹¦“¯ƒ^ƒXƒN‚Ì�‡‚É”z—ñ‚µ�C”F’m“I•‰‰×‚âˆÓ–¡Œð�‚̗ʂª’iŠK“I‚É‘�‚¦‚é�\�¬‚Æ‚µ‚½�BŠJ”­‚µ‚½‹³�Þ‚ð—p‚¢‚½ƒ^ƒ“ƒfƒ€Šw�K‚ÌŽÀ‘H‚É‚¨‚¢‚Ä�CŽQ‰ÁŽÒ‚©‚狳�Þ‚Ì�\�¬‚âƒgƒsƒbƒN‚ÉŠÖ‚µ�‚‚¢•]‰¿‚ª“¾‚ç‚ꂽ�Bˆê•û‚Å�Cƒ^ƒXƒN�‹�s’†‚Ì‚â‚èŽæ‚è‚ð•ª�Í‚µ‚½‚Æ‚±‚ë�C“ïˆÕ“x‚ª�‚‚¢‹¦“¯ƒ^ƒXƒN‚É‚¨‚¢‚Ä�C—¯Šw�¶‚Ì—�‰ð“x‚ª’á‚­�CˆÓŽvŒˆ’è‚̃vƒ�ƒZƒX‚Ö‚ÌŠÖ—^‚ª•s�\•ª‚ÈŽ–—ႪŠÏŽ@‚³‚ꂽ�B
en-copyright=
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en-aut-name=SUESHIGEMiwa
en-aut-sei=SUESHIGE
en-aut-mei=Miwa
kn-aut-name=––”É”ü˜a
kn-aut-sei=––”É
kn-aut-mei=”ü˜a
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Institute for Promotion of Education and Campus Life
kn-affil=‰ªŽR‘åŠw‹³ˆç�„�i‹@�\
en-keyword=ƒ^ƒ“ƒfƒ€ (Tandem learning)
kn-keyword=ƒ^ƒ“ƒfƒ€ (Tandem learning)
en-keyword=‹³�ÞŠJ”­ (development of Japanese language materials)
kn-keyword=‹³�ÞŠJ”­ (development of Japanese language materials)
en-keyword=Ž©—¥Šw�K (autonomous learning)
kn-keyword=Ž©—¥Šw�K (autonomous learning)
en-keyword=ƒ^ƒXƒN (tasks)
kn-keyword=ƒ^ƒXƒN (tasks)
en-keyword=Ž‹“_•\Œ» (perspective expressions)
kn-keyword=Ž‹“_•\Œ» (perspective expressions)
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=265
end-page=279
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240329
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Systematic Improvement of Teaching to Realize the School�fs Educational Goals -Japanese Language Instruction as the core of the Program-
kn-title=�u–ÚŽw‚·�¶“k‘œ�v‚ðˆÓŽ¯‚µ‚½‘g�D“I‚ÈŽö‹Æ‰ü‘P �`�uŽ©‚çŠw‚Ñ�AŽv‚¢‚â�l‚¦‚ð“`‚¦�‡‚¤—Í�v‚ðˆç‚Þ�‘Œê‰ÈŽw“±‚ðŽ²‚Æ‚µ‚Ä�`
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=�@–{Œ¤‹†‚Ì–Ú“I‚Í�A�u–ÚŽw‚·�¶“k‘œ�v‚ðˆÓŽ¯‚µ‚½Šw�Z‚Ì‘g�D‰ü‘P‚Ì‹ï‘Ì‚ð•ñ��‚µ�A‚»‚Ì‚ ‚è•û‚ð’ñŒ¾‚·‚邱‚Æ‚É‚ ‚é�B‚¢‚‚̎ž‘ã‚É‚¨‚¢‚Ä‚à�AŽö‹Æ‰ü‘P‚Í‹³Žt‚É‹�‚ß‚ç‚ê‚邱‚Æ‚Å‚ ‚é�B‹³Žt‚Í�A‚æ‚è‚æ‚¢Žö‹Æ‚ð‚µ‚½‚¢‚Ɗ肤‚à‚Ì‚Ì�A–{Ž¿“I‚ÉŽö‹Æ‚Í‚¨‚à‚µ‚ë‚­‚È‚¢‚à‚Ì‚Æ‚µ‚Ä�AŽq‚Ç‚à‚½‚¿‚É‚Í”FŽ¯‚³‚ê‚Ä‚¢‚é‚Ì‚ªŒ»�ó‚Å‚ ‚é�B–{Œ¤‹†‚Å‚Í�A‹¤—LƒrƒWƒ‡ƒ“‚Å‚ ‚é�u–ÚŽw‚·�¶“k‘œ�v‚ðŽ²‚Æ‚µ‚½‹¦“­“I‚ÈŽö‹Æ‰ü‘P‚ÌŽæ‚è‘g‚Ý‚ð•ñ��‚·‚é�B‚»‚µ‚Ä�A�u–ÚŽw‚·�¶“k‘œ�v‚ð‹³�Eˆõ‚ªˆêŠÛ‚Æ‚È‚Á‚Ä�ì‚è�A‰ðŽß�AŽÀ‘H�AŒŸ“¢‚µ‚Ä‚¢‚­‰c‚Ý‚Ì’†‚Å�A�¶“k‚ÌŽÀ‘Ô‚âŽö‹Æ‚Ì–â‘è“_‚𖾊m‚É”FŽ¯‚µ�A“¯‚¶Ž‹“_‚Å‚ÌŽö‹Æ‚̉ü‘P‚âŠw�Z‚Ì‘g�D—Í‚ÌŒü�ã‚ɂ‚Ȃª‚é‰Â”\�«‚ðŒ©�o‚·‚±‚Æ‚Æ‚·‚é�B‚³‚ç‚É�A‚±‚¤‚µ‚½Žæ‚è‘g‚Ý‚ð�i‚ß‚Ä‚¢‚­’†‚Å�A‹³Žtˆê�l‚ЂƂè‚̃�ƒ“ƒ^ƒ‹�Eƒ‚ƒfƒ‹‚ɂǂ̂悤‚ɃAƒvƒ��[ƒ`‚µ‚Ä‚¢‚­‚Ì‚©‚Æ‚¢‚¤‚±‚Æ‚ÌŽ‹�À‚à–¾‚ç‚©‚É‚µ‚Ä‚¢‚­‚±‚Æ‚Æ‚·‚é�B
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en-aut-sei=OKADA
en-aut-mei=Nami
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en-aut-name=MIYAMOTOKoji
en-aut-sei=MIYAMOTO
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kn-aut-mei=�_Ž¡
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en-aut-name=IKEDAMasafumi
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en-aut-mei=Masafumi
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en-aut-name=MAKINOShigeko
en-aut-sei=MAKINO
en-aut-mei=Shigeko
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kn-aut-mei=Ž Žq
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ORCID=

affil-num=1
en-affil=Ibara Junior High School (Graduate School of Education (Professional Degree Corse), Okayama University)
kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@�¶

affil-num=2
en-affil=Faculty of Education, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@‹³ˆçŠwˆæ

affil-num=3
en-affil=Faculty of Education, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@‹³ˆçŠwˆæ

affil-num=4
en-affil=Faculty of Education, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@‹³ˆçŠwˆæ
en-keyword=Šw�K‚·‚é‘g�D (Learning Organization)
kn-keyword=Šw�K‚·‚é‘g�D (Learning Organization)
en-keyword=Žö‹Æ‰ü‘P (Systematic improvement of teaching)
kn-keyword=Žö‹Æ‰ü‘P (Systematic improvement of teaching)
en-keyword=–ÚŽw‚·�¶“k‘œ (The school's educational goals)
kn-keyword=–ÚŽw‚·�¶“k‘œ (The school's educational goals)
en-keyword=‹³Žt‚̃�ƒ“ƒ^ƒ‹�Eƒ‚ƒfƒ‹ (Mental Models of Teachers)
kn-keyword=‹³Žt‚̃�ƒ“ƒ^ƒ‹�Eƒ‚ƒfƒ‹ (Mental Models of Teachers)
en-keyword=�‘Œê‰ÈŽw“± (Japanese language instruction)
kn-keyword=�‘Œê‰ÈŽw“± (Japanese language instruction)
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=177
end-page=189
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240329
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Creation of Disaster Preparation and Mitigation Checklists for Special Needs Schools
kn-title=’m“I�áŠQ“Á•ÊŽx‰‡Šw�Z‚É‚¨‚¯‚é”í�ÐŒã‚àŒ©�˜‚¦‚½Šw�Z–h�Ђ̂½‚߂̃`ƒFƒbƒN�€–Ú‚Ì�ì�¬
en-subtitle=
kn-subtitle=
en-abstract=School safety plans�Cwhich form the basis of school disaster prevention�Chave not yet been sufficiently developed�Ctrained�Cand reviewed for continuous improvement. In addition�Cthe teachers who handle these plans�Cespecially teachers of special-needs schools�Chave insufficient preparation systems due to their large responsibility in emergencies�Cand teachers are concerned about the consequences of such inadequacy. In this study�Cwe developed a checklist for the purpose of incorporating the post-disaster perspective of the Business Continuity Plan�iBCP�j�Cwhich is expected to become mandatory for schools in the future�Cinto school safety plans�Cand examined the validity of the checklist. As a result�Cthe usefulness of checklists was identified with the following three points: strengthening crisis management�Cpromoting community cooperation�Cand emphasizing the importance of advance preparation.
kn-abstract=�@Šw�Z–h�Ђ̊‚Æ‚È‚éŠw�ZˆÀ‘SŒv‰æ‚Í�C�ô’è�EŒP—û�EŒ©’¼‚µ“™‚É‚æ‚éŒp‘±“I‚ȉü‘P‚ª�\•ª‚É�s‚í‚ê‚Ä‚¢‚È‚¢Œ»�󂪂 ‚é�B‚Ü‚½‚»‚ê‚ðˆµ‚¤‹³ˆõ�C‚Æ‚è‚킯“Á•ÊŽx‰‡Šw�Z‹³ˆõ‚Ì�C—LŽ–‚Ì�Ó”C‚Ì‘å‚«‚³‚ÉŒ©�‡‚Á‚Ä‚¢‚È‚¢�€”õ‘Ì�§‚Ì•s�\•ª‚³�C‚»‚±‚©‚狳ˆõ‚Ì•sˆÀ‚ª”h�¶‚µ‚Ä‘¶�Ý‚·‚é�B–{Œ¤‹†‚Å‚Í�C�¡ŒãŠw�Z‚Ö‚Ì�ô’è‹`–±‰»‚ªŒ©�ž‚Ü‚ê‚鎖‹ÆŒp‘±Œv‰æ�iBCP�j‚Ì�C”í�ÐŒã‚ðŒ©�˜‚¦‚éŠÏ“_‚ð�CŠw�ZˆÀ‘SŒv‰æ‚É‘g‚Ý“ü‚ê‚邱‚Æ‚ð–Ú“I‚Ƀ`ƒFƒbƒN�€–Ú‚ð�ì�¬‚µ‚½�B‚»‚̑Ó–�«‚ÌŒŸ“¢‚ð�s‚¤‚½‚ß‚É�C“Á•ÊŽx‰‡Šw�Z‹³ˆõ‚Q–¼‚ɃCƒ“ƒ^ƒrƒ…�[’²�¸‚ð�s‚Á‚½�B‚»‚ÌŒ‹‰Ê�C–{ƒ`ƒFƒbƒN�€–Ú‚ÉŒW‚é�C”í�ÐŒã‚ðŒ©’Ê‚·ŠÏ“_‚̎擾�C‹Ù‹}‘Ήž�E•œ‹Œ‘Ήž‹Æ–±‚̃^ƒCƒ~ƒ“ƒO‚Ö‚Ì‹C‚«�C‘¼‚ÌŠw�Z‚ÌŽæ‚è‘g‚Ý‚©‚ç‚Ì�U‚è•Ô‚è�C‚Ì‚R“_‚Ì—L—p�«‚ªŽ¦�´‚³‚ꂽ�B‰Û‘è‚Æ‚µ‚Ä‚Í�C‘Ó–�«‚ÌŒŸ�Ø�C‹ï‘Ì�«‚ÌŒŸ“¢�CŠw�Z‹³ˆçˆÈŠO‚ÌŽ–‹Æ‘Ì‚©‚ç‚Ì�…•½“WŠJ‚ÌŒŸ“¢�C‚Ì‚R“_‚ª‹“‚°‚ç‚ꂽ�B
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ORCID=

en-aut-name=AKAGIKyogo
en-aut-sei=AKAGI
en-aut-mei=Kyogo
kn-aut-name=�Ô–Ø‹±Œá
kn-aut-sei=�Ô–Ø
kn-aut-mei=ܱ·
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Master�fs degree program student of Graduate School of Education�COkayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@�¶

affil-num=2
en-affil=Faculty of Education�COkayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@‹³ˆçŠwˆæ
en-keyword=BCP
kn-keyword=BCP
en-keyword=Šw�ZˆÀ‘SŒv‰æ
kn-keyword=Šw�ZˆÀ‘SŒv‰æ
en-keyword=�ЊQ
kn-keyword=�ЊQ
en-keyword=Šw�Z–h�Ð
kn-keyword=Šw�Z–h�Ð
en-keyword=“Á•ÊŽx‰‡Šw�Z
kn-keyword=“Á•ÊŽx‰‡Šw�Z
en-keyword=Disaster Preparation and Management for Schools
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en-keyword=Special Needs School
kn-keyword=Special Needs School
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=135
end-page=149
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240329
dt-online=
en-article=
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en-subject=
kn-subject=
en-title=A Study on the Formation of Educational Philosophy of Collaboration Coordinators Linking Schools and Communities -Focusing on the Process of Embodying Ideals-
kn-title=Šw�Z‚Æ’nˆæ‚ð‚‚Ȃ®˜AŒgŽx‰‡ˆõ‚Ì‹³ˆçŠÏŒ`�¬‚ÉŠÖ‚·‚錤‹† �\—�‘z‚ð‹ï‘̉»‚·‚é‰ß’ö‚É’�–Ú‚µ‚Ä�\
en-subtitle=
kn-subtitle=
en-abstract=�@This research focuses on the educational philosophy of collaboration coordinators and aims to clarify the ideals regarding education and the process of their realization among collaboration coordinators, through interview surveys. The subjects are four individuals with experience as collaboration coordinators in Y Prefecture. In recent years, with the promotion of an "education curriculum open to society," there has been progress in the development of classes in collaboration with local communities and the placement of collaboration coordinators, including "local coordinators," in school settings. Quantitative research, such as the National Prefectural Education Directors Association Subcommittee (2019) and the Regional Education Attraction Platform (2019), has been conducted to understand the actual conditions of collaboration coordinators, drawing attention to their role. This research aims to analyze the ideals and the process of materializing these concepts of collaboration coordinators, who serve as a bridge between schools and communities, and to elucidate the process of forming their educational philosophy.
kn-abstract=�@–{Œ¤‹†‚Í�CŠO•”�l�Þ‚Ì‹³ˆçŠÏ‚É’…–Ú‚µ�CƒCƒ“ƒ^ƒrƒ…�[’²�¸‚ð’Ê‚µ‚ĘAŒgŽx‰‡ˆõ‚Ì‹³ˆç‚ÉŠÖ‚·‚é—�‘z‚Æ‚»‚Ì‹ï‘̉»‚̉ߒö‚𖾂炩‚É‚µ‚悤‚Æ‚·‚é‚à‚Ì‚Å‚ ‚é�B‘Î�Û‚Æ‚·‚é‚Ì‚Í�C‚xŒ§‚ŘAŒgŽx‰‡ˆõ‚Æ‚µ‚ÄŠˆ“®‚µ‚½ŒoŒ±‚ðŽ�‚Â4–¼‚Å‚ ‚é�B‹ß”N�C�uŽÐ‰ï‚ÉŠJ‚©‚ꂽ‹³ˆç‰Û’ö�v‚Ì�„�i‚É‚æ‚è�C’nˆæ‚ƘAŒg‚µ‚½Žö‹Æ‚ÌŠJ”­‚âŠw�ZŒ»�ê‚É‚¨‚¯‚é�u’nˆæƒR�[ƒfƒBƒl�[ƒ^�[�v‚ð‚Í‚¶‚ß‚Æ‚µ‚½˜AŒgŽx‰‡ˆõ‚Ì”z’u‚ª�i‚ñ‚Å‚¢‚é�B‘S�‘“s“¹•{Œ§‹³ˆç’·‹¦‹c‰ï‘æ‚Q•”‰ï(2019)‚â’nˆæ�E‹³ˆç–£—͉»ƒvƒ‰ƒbƒgƒtƒH�[ƒ€(2019)‚È‚Ç‚É‚æ‚è˜AŒgŽx‰‡ˆõ‚ÌŽÀ‘Ô‚É”—‚Á‚½—Ê“IŒ¤‹†‚ª�s‚í‚ê‚é‚È‚Ç�C˜AŒgŽx‰‡ˆõ‚É’�–Ú‚ª�W‚Ü‚Á‚Ä‚¢‚é�B–{Œ¤‹†‚Å‚Í�CŠw�Z‚Æ’nˆæ‚Ì‹´“n‚µ‹@”\‚ð‰Ê‚½‚µ‚Ä‚¢‚é˜AŒgŽx‰‡ˆõ‚Ì—�‘z‚Æ�C‚»‚Ì—�”O‚Ì‹ï‘̉»‚̉ߒö‚ð•ª�Í‚µ�C˜AŒgŽx‰‡ˆõ‚Ì‹³ˆçŠÏ‚ªŒ`�¬‚³‚ê‚é‰ß’ö‚ð‰ð–¾‚µ‚½‚¢�B
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en-aut-name=HATANOMasatoshi
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ORCID=

en-aut-name=KUWABARAToshinori
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en-aut-mei=Toshinori
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kn-aut-mei=•q“T
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Graduate School of Education, Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@�¶

affil-num=2
en-affil=Faculty of Education, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@‹³ˆçŠwˆæ
en-keyword=˜AŒgŽx‰‡ˆõ (collaboration coordinators)
kn-keyword=˜AŒgŽx‰‡ˆõ (collaboration coordinators)
en-keyword=‹³ˆçŠÏ (educational view)
kn-keyword=‹³ˆçŠÏ (educational view)
en-keyword=—�‘z (ideal)
kn-keyword=—�‘z (ideal)
en-keyword=‹ï‘̉» (embodiment)
kn-keyword=‹ï‘̉» (embodiment)
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=87
end-page=101
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240329
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Introduction and Effective Use of Individualized Education Program of Learning in Regular Class (LRC) in China
kn-title=’†‰Ø�l–¯‹¤˜a�‘‚Ì��”Ç�A“Ç‚É‚¨‚¯‚éŒÂ•Ê‰»‹³ˆçŒv‰æ‚Ì“±“ü‚ÆŒø‰Ê“I‚ÈŠˆ—p•û�ô
en-subtitle=
kn-subtitle=
en-abstract=The purpose of this study is to clarify the issues for the preparation and effective use of individualized education program (IEP) in Learning in Regular Class (LRC), and to propose improvement measures. We conducted an interview survey of five elementary and junior teachers who had experience in LRC. The difficulties in preparing an IEP were the following: (1) issues related to the LRC policy, (2) issues related to cooperation with parents, (3) practical issues for teachers in preparing an IEP. In response to these issues, it is necessary to formulate detailed legal regulations on LRC, clarify how to deal with students with disabilities after their admission. Efforts from schools and parents are indispensable. In addition, it is necessary to increase the awareness of IEP and the rate of formulation and providing support from various fields in preparation of IEP. In addition, it was important that there is not enough just to create a plan, but how to utilize it.
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en-copyright=
kn-copyright=

en-aut-name=HUJueying
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en-aut-mei=Jueying
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kn-aut-mei=?‰n
aut-affil-num=1
ORCID=

en-aut-name=YOSHITOSHIMunehisa
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en-aut-mei=Munehisa
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kn-aut-sei=‹g—˜
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aut-affil-num=2
ORCID=

affil-num=1
en-affil=Student at the Graduate School of Education, Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È‘åŠw‰@�¶

affil-num=2
en-affil=Faculty of Education, Okayama University
kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@‹³ˆçŠwˆæ
en-keyword=’†‰Ø�l–¯‹¤˜a�‘ (People's Republic of China)
kn-keyword=’†‰Ø�l–¯‹¤˜a�‘ (People's Republic of China)
en-keyword=��”Ç�A“Ç (Learning in Regular Class (LRC))
kn-keyword=��”Ç�A“Ç (Learning in Regular Class (LRC))
en-keyword=ŒÂ•Ê‰»‹³ˆçŒv‰æ (Individualized Education Program)
kn-keyword=ŒÂ•Ê‰»‹³ˆçŒv‰æ (Individualized Education Program)
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
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article-no=
start-page=47
end-page=55
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240329
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en-title=Implementation and Evaluation of Teacher Training on Food Allergy Education in Kindergarten �\ Aiming to Foster Children Leading Healthy Lives, Regardless of the Presence of Food Allergies �\
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en-abstract=This study aims to explore strategies for nurturing kindergarten children with food allergies. Teacher training on food allergy education was conducted, and its effectiveness was evaluated based on teacher reactions and pre- and post-training surveys. The training deepened the understanding of the importance of addressing the emotional needs of children with food allergies. Case studies revealed the necessity of conveying this understanding to preschoolers and equipping them to respond appropriately. The study also observed teachers navigating between traditional and evolving educational perspectives, with observed fluctuations and conflicts contributing to refining teachers' beliefs tow ard embracing individual needs and diversity.
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en-keyword=�H•¨ƒAƒŒƒ‹ƒM�[‹³ˆç (Food Allergy Education)
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en-title=Die ?bersetzung von Jherings Briefe�i6�j
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en-title=Analysis of Regional Multiplier of Knowledge Intensive Industries and Creative Jobs based on Economic Base Model: Benefit of Municipal Collaboration
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kn-abstract=�@The traditional economic base model in the field of regional science contributes to identifying regional income producing industries and labor absorption. The economic base model has some conditional assumptions while it is quite tractable.<br>
�@Recently, papers by Moretti and others show significant regional multiplier effects of innovative jobs. They refocused on the traditional economic base model. However, their approach has several deficiencies concerning the identification of basic/non-basic industries and ambiguity of multiplier generating mechanisms.<br>
�@This paper focuses on regional specialization of knowledge intensive industries and creative jobs which are the driving forces of regional development in the framework of the economic base model. The estimations of regional economic multiplier in terms of employment are carried out using two-digit employment and three-digit job classification data at local municipality level with two-period data. Using these data, I explain regional differences by degree of specialization of knowledge intensive industries and creative workers. By doing this, I propose contemporary regional economic policy. Furthermore, by comparing multiplier effects at local municipality level and regional employment area level, benefits of municipal consolidation are shown.
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en-aut-name=NakamuraRyohei
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en-title=Outsourcing of Extracurricular Activities�\ Current Status and Future Issues, Attempt at Okayama University �\
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en-aut-name=SuzukiHisao
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en-title=Current Status and Issues of Teachers�f Overwork
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en-title=A Study on a Cooperation Procedure to Construct Whole and Annual Guidance Plans of Care and Education in a Nursery School for Children Aged Zero to Two
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en-title=Study on the Development of Consumer Education Programs Aimed at Developing Independent Legal Decision-Making Skills: -Based on a Study of the Theory of Value Formation in Social Studies Education
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en-title=Relationship between the Experience of Identity Swaying in Childcare Practice and Childcare Workers�f Efficacy
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kn-abstract=�@This study aims to examine the relationship between childcare workers�f �gexperience of identity swaying�h as described in their autobiographical memory and their occupation efficacy. First, the influence that stemmed from the experience of childcare workers�f swaying on their sense of efficacy is examined. The results showed that those who experienced identity swaying in their autobiographical memory had a remarkably higher sense of efficacy as childcare workers than those who didn�ft. On the other hand, no difference was found in their sense of efficacy depending on the trigger of the identity swaying. The differences in childcare workers�f descriptions depending on the level of their sense of efficacy were then investigated the records of childcare workers with a high sense of occupation efficacy showed a higher level of ego involvement stays as a memory that can be utilized in the future. Closing the article, the authors examine future issues.
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en-title=Organizational Safety and Teamwork: Overview of the Existing Findings Based on the Perspective of Teamwork Breakdown and High Reliability Teams
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en-title=A Study on Experiences and Understandings of Educational Counseling for Teacher Training Course Students : Toward the Establishment of Educational Counseling Activities in Schools
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en-aut-name=IZUMITsuguyuki
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en-aut-mei=Tsuguyuki
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en-affil=Faculty of Education, Okayama University
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en-keyword=‹³ˆç‘Š’kŠˆ“®
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en-keyword=‹³ˆç‘Š’kƒR�[ƒfƒBƒl�[ƒ^�[
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cd-journal=joma
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dt-pub-year=2024
dt-pub=20240331
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en-title=Annual report / Institute of Plant Science and Resources, Okayama University
kn-title=‰ªŽR‘åŠwŽ‘Œ¹�A•¨‰ÈŠwŒ¤‹†�Š•ñ��
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en-aut-name=Institute of Plant Science and Resources, Okayama University
en-aut-sei=Institute of Plant Science and Resources, Okayama University
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affil-num=1
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cd-journal=joma
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start-page=292
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dt-accepted=
dt-pub-year=2024
dt-pub=20240226
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en-subject=
kn-subject=
en-title=Telling of the Trouble in Mediation
kn-title=‘ΘbŒ^’²’â‚Å‚Ì”ñ’èŒ^“I‚È•´‘ˆ‚ÌŒê‚è
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en-aut-name=LiY.
en-aut-sei=Li
en-aut-mei=Y.
kn-aut-name=—›‰p
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aut-affil-num=1
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affil-num=1
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kn-affil=‰ªŽR‘åŠwŠw�pŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=1
article-no=
start-page=e0296408
end-page=
dt-received=
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dt-accepted=
dt-pub-year=2024
dt-pub=20240105
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en-title=
kn-title=Aromatic oil from lavender as an atopic dermatitis suppressant
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kn-subtitle=
en-abstract=
kn-abstract=In atopic dermatitis (AD), nerves are abnormally stretched near the surface of the skin, making it sensitive to itching. Expression of neurotrophic factor Artemin (ARTN) involved in such nerve stretching is induced by the xenobiotic response (XRE) to air pollutants and UV radiation products. Therefore, AD can be monitored by the XRE response. Previously, we established a human keratinocyte cell line stably expressing a NanoLuc reporter gene downstream of XRE. We found that 6-formylindolo[3,2-b]carbazole (FICZ), a tryptophan metabolite and known inducer of the XRE, increased reporter and Artemin mRNA expression, indicating that FICZ-treated cells could be a model for AD. Lavender essential oil has been used in folk medicine to treat AD, but the scientific basis for its use is unclear. In the present study, we investigated the efficacy of lavender essential oil and its major components, linalyl acetate and linalool, to suppress AD and sensitize skin using the established AD model cell line, and keratinocyte and dendritic cell activation assays. Our results indicated that lavender essential oil from L. angustifolia and linalyl acetate exerted a strong AD inhibitory effect and almost no skin sensitization. Our model is useful in that it can circumvent the practice of using animal studies to evaluate AD medicines.
en-copyright=
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en-aut-name=SatoHaruna
en-aut-sei=Sato
en-aut-mei=Haruna
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aut-affil-num=1
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en-aut-name=KatoKosuke
en-aut-sei=Kato
en-aut-mei=Kosuke
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aut-affil-num=2
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en-aut-name=KoreishiMayuko
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en-aut-mei=Mayuko
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aut-affil-num=3
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en-aut-name=NakamuraYoshimasa
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en-aut-mei=Yoshimasa
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aut-affil-num=4
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en-aut-name=TsujinoYoshio
en-aut-sei=Tsujino
en-aut-mei=Yoshio
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aut-affil-num=5
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en-aut-name=SatohAyano
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aut-affil-num=6
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affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Science, Technology, and Innovation, Kobe University
kn-affil=

affil-num=6
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
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END

start-ver=1.4
cd-journal=joma
no-vol=42
cd-vols=
no-issue=
article-no=
start-page=15
end-page=58
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200401
dt-online=
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en-subject=
kn-subject=
en-title=
kn-title=‰^‰c : 2019”N“x
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en-copyright=
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END

start-ver=1.4
cd-journal=joma
no-vol=42
cd-vols=
no-issue=
article-no=
start-page=7
end-page=11
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200401
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en-article=
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en-subject=
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en-title=
kn-title=ŽŽŒ±Œ¤‹† : 2019”N“x
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en-abstract=
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en-copyright=
kn-copyright=
END