start-ver=1.4
cd-journal=joma
no-vol=59
cd-vols=
no-issue=
article-no=
start-page=143
end-page=163
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250328
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=An Analysis of the Function of “1Gja軍” in the Tangut Military System ―Positions of “1Gja軍” and its Relationship with “1Tśju職”―
kn-title=西夏軍制における「軍」の機能 ―「軍」に属する地位名称および「職」との関係―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ONOHiroko
en-aut-sei=ONO
en-aut-mei=Hiroko
kn-aut-name=小野裕子
kn-aut-sei=小野
kn-aut-mei=裕子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=1
article-no=
start-page=6666
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250224
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Microfluidic fabrication of rattle shaped biopolymer microcapsules via sequential phase separation in oil droplets
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Multilayer microcapsules containing a small particle within a larger capsule have recently attracted considerable attention owing to their potential applications in diverse fields, including drug delivery, active ingredient storage, and chemical reactions. These complex capsules have been fabricated using interfacial polymerization or seeded emulsion polymerization. However, these methods often require complex and lengthy polymerization processes, limiting their utility, particularly in biopolymer systems. This study introduces a simple and efficient approach for preparing rattle-shaped cellulose acetate (CA) microcapsules through sequential phase separation in droplets. We systematically examine the effects of various preparation parameters, including the amount of co-solvent, initial droplet size, and flow rates, and reveal that the incorporation of a co-solvent-ethyl acetate (EA)- in the dispersed phase significantly impacts the microcapsule morphology. Our findings demonstrate a transition from a core-shell to a rattle-shaped structure as the EA concentration increases. Furthermore, the initial droplet diameter and flow rates influence microcapsule formation-larger droplets and reduced continuous-phase flow rates favor the development of multi-layered structures. These results indicate that the formation mechanism of these rattle-shaped microcapsules arises from the establishment of a radial solvent concentration gradient and subsequent phase separation within the droplets, driven by kinetic rather than thermodynamic factors.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SakaiYuko
en-aut-sei=Sakai
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MoriKurumi
en-aut-sei=Mori
en-aut-mei=Kurumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry, Graduate School of Environmental, Life, Natural Science and Technology
kn-affil=

affil-num=2
en-affil=Department of Applied Chemistry, Graduate School of Environmental, Life, Natural Science and Technology
kn-affil=

affil-num=3
en-affil=Department of Applied Chemistry, Graduate School of Environmental, Life, Natural Science and Technology
kn-affil=

affil-num=4
en-affil=Department of Applied Chemistry, Graduate School of Environmental, Life, Natural Science and Technology
kn-affil=
en-keyword=Microfluidics
kn-keyword=Microfluidics
en-keyword=Phase separation
kn-keyword=Phase separation
en-keyword=Nucleation
kn-keyword=Nucleation
en-keyword=Multi-core
kn-keyword=Multi-core
en-keyword=Rattle-shaped
kn-keyword=Rattle-shaped
END

start-ver=1.4
cd-journal=joma
no-vol=2024
cd-vols=
no-issue=
article-no=
start-page=8836103
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241028
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Rare Case of Multiple Myeloma Identified Following the Diagnosis of Amyloidosis of the Tongue
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Amyloidosis is a disease in which amyloid protein is deposited in organs and tissues, resulting in functional impairment. Amyloidosis occurs in 12%-30% of patients with multiple myeloma, but in rare cases, amyloidosis may precede the diagnosis of multiple myeloma. Our patient was a 76-year-old Japanese male on dialysis. Multiple nodules accompanied by ulcers were observed on his tongue. He had no subjective symptoms or clinical findings associated with multiple myeloma. The histopathological findings suggested amyloidosis. We suspected both systemic and localized amyloidosis and performed a comprehensive systemic examination. Since the patient had been on dialysis for only a short period of time (similar to 3 months), dialysis-related amyloidosis was ruled out. After blood and urine tests, a diagnosis of multiple myeloma was made. Chemotherapy treatment was started, but the patient's multiple myeloma could not be suppressed and the tongue amyloidosis worsened, leading to his death 2 years and 2 months after the initial diagnosis.
en-copyright=
kn-copyright=

en-aut-name=KanemotoHideka
en-aut-sei=Kanemoto
en-aut-mei=Hideka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ObataKyoichi
en-aut-sei=Obata
en-aut-mei=Kyoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KadoyaKoichi
en-aut-sei=Kadoya
en-aut-mei=Koichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KawaiHotaka
en-aut-sei=Kawai
en-aut-mei=Hotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KunisadaYuki
en-aut-sei=Kunisada
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YaoMayumi
en-aut-sei=Yao
en-aut-mei=Mayumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Oral and Maxillofacial Surgery, Tsuyama Chuo Hospital
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=21
cd-vols=
no-issue=5
article-no=
start-page=464
end-page=473
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240827
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Terrein Exhibits Anti-tumor Activity by Suppressing Angiogenin Expression in Malignant Melanoma Cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background/Aim: Malignant melanoma is a tumor with a poor prognosis that can metastasize distally at an early stage. Terrein, a metabolite produced by Aspergillus terreus, suppresses the expression of angiogenin, an angiogenic factor. However, the pharmacological effects of natural terrein have not been elucidated, because only a small amount of terrein can be extracted from large fungal cultures. In this study, we investigated the antineoplastic effects of terrein on human malignant melanoma cells and its underlying mechanisms. Materials and methods: Human malignant melanoma cell lines were cultured in the presence of terrein and analyzed. Angiogenin production was evaluated using ELISA. Ribosome biosynthesis was evaluated using silver staining of the nucleolar organizer region. Intracellular signaling pathways were analyzed using western blotting. Malignant melanoma cells were transplanted subcutaneously into the backs of nude mice. The tumors were removed at 5 weeks and analyzed histopathologically. Results: Terrein inhibited angiogenin expression, proliferation, migration, invasion, and ribosome biosynthesis in malignant melanoma cells. Terrein was shown to inhibit tumor growth and angiogenesis in animal models. Conclusion: This study demonstrated that terrein has anti-tumor effects against malignant melanoma. Furthermore, chemically synthesized non-natural terrein can be mass-produced and serve as a novel potential anti-tumor drug candidate.
en-copyright=
kn-copyright=

en-aut-name=HIROSETAIRA
en-aut-sei=HIROSE
en-aut-mei=TAIRA
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KUNISADAYUKI
en-aut-sei=KUNISADA
en-aut-mei=YUKI
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KADOYAKOICHI
en-aut-sei=KADOYA
en-aut-mei=KOICHI
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MANDAIHIROKI
en-aut-sei=MANDAI
en-aut-mei=HIROKI
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SAKAMOTOYUMI
en-aut-sei=SAKAMOTO
en-aut-mei=YUMI
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OBATAKYOICHI
en-aut-sei=OBATA
en-aut-mei=KYOICHI
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ONOKISHO
en-aut-sei=ONO
en-aut-mei=KISHO
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TAKAKURAHIROAKI
en-aut-sei=TAKAKURA
en-aut-mei=HIROAKI
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OMORIKAZUHIRO
en-aut-sei=OMORI
en-aut-mei=KAZUHIRO
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TAKASHIBASHOGO
en-aut-sei=TAKASHIBA
en-aut-mei=SHOGO
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SUGASEIJI
en-aut-sei=SUGA
en-aut-mei=SEIJI
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=IBARAGISOICHIRO
en-aut-sei=IBARAGI
en-aut-mei=SOICHIRO
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Pharmacy, Faculty of Pharmacy, Gifu University of Medical Science
kn-affil=

affil-num=5
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Pathophysiology-Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Pathophysiology-Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=11
en-affil=Division of Applied Chemistry, Graduate School of Natural Sciences and Technology, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=Head and neck cancer
kn-keyword=Head and neck cancer
en-keyword=oral cancer
kn-keyword=oral cancer
en-keyword=malignant melanoma
kn-keyword=malignant melanoma
en-keyword=angiogenin
kn-keyword=angiogenin
en-keyword=terrein
kn-keyword=terrein
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=341
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240813
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Pathological findings in enucleated eyes of patients with neurofibromatosis type 1: report of a case with 15-year follow-up and review of 14 patients in the literature
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Backgrounds Iris nodules are frequently noted as clinical manifestations of neurofibromatosis type 1 but the other intraocular manifestations are rare. The purpose of this study is to present a patient with a phthisic eye who underwent enucleation for a cosmetic reason after 15-year follow-up and also to review 14 patients with enucleation described in the literature.<br>
Case presentation A 17-year-old man with neurofibromatosis type 1 from infancy underwent the enucleation of phthisic left eye and also had the resection of eyelid subcutaneous mass lesions on the left side for a cosmetic reason. He had undergone four-time preceding surgeries for eyelid and orbital mass reduction on the left side in childhood and had developed total retinal detachment 10 years previously. Pathologically, the enucleated eye showed massive retinal gliosis positive for both S-100 and glial fibrillary acidic protein (GFAP) in the area with involvement of the detached retinal neuronal layer, together with a more fibrotic lesion along the choroid which were, in contrast, negative for both S-100 and GFAP. The choroid, ciliary body, and iris did not show apparent neurofibroma while episcleral neurofibroma was present.<br>
Literature review In review of enucleated eyes of 14 patients in the literature, buphthalmic eyes with early-onset glaucoma on the unilateral side was clinically diagnosed in 9 patients who frequently showed varying extent of hemifacial neurofibromatosis which involved the eyelid and orbit on the same side. Pathologically, neurofibromas in varying extent were found in the choroid of 12 patients. One patient showed choroidal malignant melanoma on the left side and fusiform enlargement of the optic nerve on the right side suspected of optic nerve glioma. The phthisic eye in another patient showed massive retinal gliosis similar to the present patient.<br>
Conclusions In summary of the 15 patients with neurofibromatosis type 1, including the present patient, buphthalmic or phthisic eyes with no vision were enucleated for cosmetic reasons and showed choroidal neurofibroma in most patients and massive retinal gliosis in two patients including the present patient.
en-copyright=
kn-copyright=

en-aut-name=MatsuoToshihiko
en-aut-sei=Matsuo
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NishidaKenji
en-aut-sei=Nishida
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SenoTakaya
en-aut-sei=Seno
en-aut-mei=Takaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamadaKiyoshi
en-aut-sei=Yamada
en-aut-mei=Kiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OnoShigeki
en-aut-sei=Ono
en-aut-mei=Shigeki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Pathology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Pathology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Neurological Surgery, General Medical Center, Kawasaki Medical School
kn-affil=
en-keyword=Neurofibromatosis type 1
kn-keyword=Neurofibromatosis type 1
en-keyword=Enucleation
kn-keyword=Enucleation
en-keyword=Eye
kn-keyword=Eye
en-keyword=Pathology
kn-keyword=Pathology
en-keyword=Massive retinal gliosis
kn-keyword=Massive retinal gliosis
en-keyword=Choroidal neurofibroma
kn-keyword=Choroidal neurofibroma
en-keyword=Phthisis
kn-keyword=Phthisis
en-keyword=Buphthalmos
kn-keyword=Buphthalmos
en-keyword=Malignant melanoma
kn-keyword=Malignant melanoma
en-keyword=Cosmetic surgery
kn-keyword=Cosmetic surgery
END

start-ver=1.4
cd-journal=joma
no-vol=51
cd-vols=
no-issue=
article-no=
start-page=15
end-page=26
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=『三ギニー』における風刺の考察―皮肉的風刺表現―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野和子
kn-aut-sei=小野
kn-aut-mei=和子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科博士前期課程修了生
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=10
article-no=
start-page=e174618
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240522
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Double-faced CX3CL1 enhances lymphangiogenesis-dependent metastasis in an aggressive subclone of oral squamous cell carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Because cancer cells have a genetically unstable nature, they give rise to genetically different variant subclones inside a single tumor. Understanding cancer heterogeneity and subclone characteristics is crucial for developing more efficacious therapies. Oral squamous cell carcinoma (OSCC) is characterized by high heterogeneity and plasticity. On the other hand, CX3C motif ligand 1 (CX3CL1) is a double-faced chemokine with anti- and pro -tumor functions. Our study reported that CX3CL1 functioned differently in tumors with different cancer phenotypes, both in vivo and in vitro. Mouse OSCC 1 (MOC1) and MOC2 cells responded similarly to CX3CL1 in vitro. However, in vivo, CX3CL1 increased keratinization in indolent MOC1 cancer, while CX3CL1 promoted cervical lymphatic metastasis in aggressive MOC2 cancer. These outcomes were due to double-faced CX3CL1 effects on different immune microenvironments indolent and aggressive cancer created. Furthermore, we established that CX3CL1 promoted cancer metastasis via the lymphatic pathway by stimulating lymphangiogenesis and transendothelial migration of lymph -circulating tumor cells. CX3CL1 enrichment in lymphatic metastasis tissues was observed in aggressive murine and human cell lines. OSCC patient samples with CX3CL1 enrichment exhibited a strong correlation with lower overall survival rates and higher recurrence and distant metastasis rates. In conclusion, CX3CL1 is a pivotal factor that stimulates the metastasis of aggressive cancer subclones within the heterogeneous tumors to metastasize, and our study demonstrates the prognostic value of CX3CL1 enrichment in long-term monitoring in OSCC.
en-copyright=
kn-copyright=

en-aut-name=EainHtoo Shwe
en-aut-sei=Eain
en-aut-mei=Htoo Shwe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KawaiHotaka
en-aut-sei=Kawai
en-aut-mei=Hotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakayamaMasaaki
en-aut-sei=Nakayama
en-aut-mei=Masaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OoMay Wathone
en-aut-sei=Oo
en-aut-mei=May Wathone
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OharaToshiaki
en-aut-sei=Ohara
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=FukuharaYoko
en-aut-sei=Fukuhara
en-aut-mei=Yoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakabatakeKiyofumi
en-aut-sei=Takabatake
en-aut-mei=Kiyofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ShanQuisheng
en-aut-sei=Shan
en-aut-mei=Quisheng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SoeYamin
en-aut-sei=Soe
en-aut-mei=Yamin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=NakanoKeisuke
en-aut-sei=Nakano
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=MizukawaNobuyoshi
en-aut-sei=Mizukawa
en-aut-mei=Nobuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=IidaSeiji
en-aut-sei=Iida
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=NagatsukaHitoshi
en-aut-sei=Nagatsuka
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Oral Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama Universit
kn-affil=

affil-num=6
en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Oral and Maxillofacial Reconstructive Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=13
en-affil=Department of Oral and Maxillofacial Reconstructive Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=14
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=自然と人間の共生観を育むための生活科及び理科教育の基礎的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ONODERAKaren
en-aut-sei=ONODERA
en-aut-mei=Karen
kn-aut-name=小野寺かれん
kn-aut-sei=小野寺
kn-aut-mei=かれん
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=西夏軍制史の研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ONOHiroko
en-aut-sei=ONO
en-aut-mei=Hiroko
kn-aut-name=小野裕子
kn-aut-sei=小野
kn-aut-mei=裕子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=40
cd-vols=
no-issue=15
article-no=
start-page=8074
end-page=8082
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240405
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Engineering Interconnected Open-Porous Particles via Microfluidics Using Bijel Droplets as Structural Templates
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Designing porous structures is key in materials science, particularly for separation, catalysis, and cell culture systems. Bicontinuous interfacially jammed emulsion gels represent a unique class of soft matter formed by kinetically arresting the separation of the spinodal decomposition phase, which is stabilized by colloidal particles with neutral wetting. This study introduces a microfluidic technique to create highly interconnected open-porous particles using bijel droplets stabilized with hexadecyltrimethylammonium bromide (CTAB)-modified silica particles. Monodisperse droplets comprising a hydrophobic monomer, water, ethanol, silica particles, and CTAB were initially formed in the microfluidic device. The diffusion of ethanol from these droplets into the continuous cyclohexane phase triggered spinodal decomposition within the droplets. The phase-separated structure within the droplets was stabilized by the CTAB-modified silica particles, and subsequent photopolymerization yielded microparticles with highly interconnected, open pores. Moreover, the influence of the ratio of the CTAB and silica particles, fluid composition, and microchannel direction on the final structure of the microparticles was explored. Our findings indicated that the phase-separated structure of the particles transitioned from oil-in-water to water-in-oil as the CTAB/silica ratio was increased. At intermediate CTAB/silica ratios, microparticles with bicontinuous structures were formed. Regardless of the fluid composition, the pore size of the particles increased with time after phase separation. However, this coarsening was arrested 15 s after droplet formation in the CTAB-modified silica particles, accompanied by a change in the particle shape from spherical to ellipsoidal. In situ observations of the bijel droplet formation revealed that the particle shape deformation is caused by the rolling of elastic bijel droplets at the bottom of the microchannel. As such, the channel setup was altered from horizontal to vertical to prevent the deformation of bijel droplets, resulting in spherical particles with open pores.
en-copyright=
kn-copyright=

en-aut-name=MasaokaMina
en-aut-sei=Masaoka
en-aut-mei=Mina
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IshidaHiroaki
en-aut-sei=Ishida
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190329
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Newsletter from Course for Prospective Museum Workers, Faculty of Letters, Okayama University
kn-title=学芸員課程 Newsletter 第12号
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=光本順
kn-aut-sei=光本
kn-aut-mei=順
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=鈴木恒志
kn-aut-sei=鈴木
kn-aut-mei=恒志
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=木下莉沙
kn-aut-sei=木下
kn-aut-mei=莉沙
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=黒木恵那
kn-aut-sei=黒木
kn-aut-mei=恵那
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=多田絢音
kn-aut-sei=多田
kn-aut-mei=絢音
aut-affil-num=5
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野田澪
kn-aut-sei=小野田
kn-aut-mei=澪
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=文学部

affil-num=2
en-affil=
kn-affil=文学部 哲学芸術学専修コース

affil-num=3
en-affil=
kn-affil=文学部 地理学・社会学・文化人類学・社会文化学分野

affil-num=4
en-affil=
kn-affil=文学部 歴史学・考古学分野

affil-num=5
en-affil=
kn-affil=文学部 芸術学・美術史分野

affil-num=6
en-affil=
kn-affil=文学部 歴史学・考古学分野
END

start-ver=1.4
cd-journal=joma
no-vol=43
cd-vols=
no-issue=11
article-no=
start-page=4993
end-page=5001
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202311
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Multimodal Prediction of Cervical Lymph Node Metastasis and Recurrence in Oral Squamous Cell Carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background/Aim: Oral squamous cell carcinoma (OSCC) is the most common malignancy in the head/neck region, and cervical lymph node (CLN) metastasis is a strong poor-prognosis factor. In addition, many patients with OSCC experience recurrence despite multidisciplinary treatment. We sought to identify factors associated with CLN metastasis and recurrence in patients with OSCC. Patients and Methods: We evaluated a total of 45 patients and 233 target CLNs. The longest diameter of the target CLN, the shortest diameter of the target CLN (LS), the area of the target CLN, and the relative computed tomography (CT) values of the target CLNs calculated based on the CT values of the internal jugular vein (LCT) were obtained from preoperative CT images, and the maximum standardized uptake values of the primary tumor (pSUV) and target CLN (nSUV) were obtained from preoperative 18F-fluorodeoxyglucose-positron emission tomography/CT images. We performed immunohistochemical staining for cytokeratin 13 (CK13) and 17 (CK17) on neck dissection tissues. Results: A discrimination equation was used that can predict CLN metastasis with a 92.2% discrimination rate using LS, LCT, pSUV, and nSUV. The CLNs were divided into discrimination and non-discrimination groups based on discriminant equations and CK13 and CK17 were used as the objective variables. A significantly higher recurrence rate was observed in the non-discrimination group (CK13: 5-year recurrence rate 28.6% vs. 64.3%, p<0.01; CK17: 5-year recurrence rate 28.0% vs. 76.0%, p<0.01). Conclusion: CLN metastases in OSCC can be assessed by combining preoperative imaging. The combined use of CK13 and CK17 expression with imaging findings offers an integrated approach to predict OSCC recurrence.
en-copyright=
kn-copyright=

en-aut-name=KANEMOTOHIDEKA
en-aut-sei=KANEMOTO
en-aut-mei=HIDEKA
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OBATAKYOICHI
en-aut-sei=OBATA
en-aut-mei=KYOICHI
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=UMEMORIKOKI
en-aut-sei=UMEMORI
en-aut-mei=KOKI
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HASEGAWAKAZUAKI
en-aut-sei=HASEGAWA
en-aut-mei=KAZUAKI
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ONOSAWAKO
en-aut-sei=ONO
en-aut-mei=SAWAKO
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ONOKISHO
en-aut-sei=ONO
en-aut-mei=KISHO
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YUTORIHIROKAZU
en-aut-sei=YUTORI
en-aut-mei=HIROKAZU
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IBARAGISOICHIRO
en-aut-sei=IBARAGI
en-aut-mei=SOICHIRO
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=5
en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Oral cancer
kn-keyword=Oral cancer
en-keyword=head and neck squamous cell carcinoma
kn-keyword=head and neck squamous cell carcinoma
en-keyword=neck dissection
kn-keyword=neck dissection
en-keyword=lymph node
kn-keyword=lymph node
en-keyword=discriminant analysis
kn-keyword=discriminant analysis
en-keyword=cytokeratin
kn-keyword=cytokeratin
END

start-ver=1.4
cd-journal=joma
no-vol=20
cd-vols=
no-issue=7
article-no=
start-page=1611
end-page=1619
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240118
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Controlled mechanical properties of poly(ionic liquid)-based hydrophobic ion gels by the introduction of alumina nanoparticles with different shapes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Ionic–liquid gels, also known as ion gels, have gained considerable attention due to their high ionic conductivity and CO2 absorption capacity. However, their low mechanical strength has hindered their practical applications. A potential solution to this challenge is the incorporation of particles, such as silica nanoparticles, TiO2 nanoparticles, and metal–organic frameworks (MOFs) into ion gels. Comparative studies on the effect of particles with different shapes are still in progress. This study investigated the effect of the shape of particles introduced into ion gels on their mechanical properties. Consequently, alumina/poly(ionic liquid) (PIL) double-network (DN) ion gels consisting of clustered alumina nanoparticles with various shapes (either spherical or rod-shaped) and a chemically crosslinked poly[1-ethyl-3-vinylimidazolium bis(trifluoromethanesulfonyl)imide] (PC2im-TFSI, PIL) network were prepared. The results revealed that the mechanical strengths of the alumina/PIL DN ion gels were superior to those of PIL single-network ion gels without particles. Notably, the fracture energies of the rod-shaped alumina/PIL DN ion gels were approximately 2.6 times higher than those of the spherical alumina/PIL DN ion gels. Cyclic tensile tests were performed, and the results indicate that the loading energy on the ion gel was dissipated through the fracture of the alumina network. TEM observation suggests that the variation in the mechanical strength depending on the shape can be attributed to differences in the aggregation structure of the alumina particles, thus indicating the possibility of tuning the mechanical strength of ion gels by altering not only particle kinds but its shape.
en-copyright=
kn-copyright=

en-aut-name=MizutaniYuna
en-aut-sei=Mizutani
en-aut-mei=Yuna
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=LopezCarlos G.
en-aut-sei=Lopez
en-aut-mei=Carlos G.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Materials Science and Engineering, The Pennsylvania State University
kn-affil=

affil-num=4
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=113
cd-vols=
no-issue=
article-no=
start-page=1
end-page=6
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Evaluator of adaptability of S. cerevisiae to grape juice using the oversxpression profiling ADOPT method
kn-title=過剰発現プロファイリングADOPT法を用いたS.cerevisiaeのワイン醸造用ブドウ果汁への適応性評価
en-subtitle=
kn-subtitle=
en-abstract=筆者らは最近，過剰発現プロファイリングADOPT 法を開発した．ADOPT 法では，出芽酵母Saccharomyces cerevisiae ゲノムのほとんどの遺伝子をそれぞれ過剰発現する酵母株を混合・競合培養し，その過程で濃縮されてきた株が過剰発現している遺伝子を体系的に同定する．さらに同定された遺伝子をたよりに，S. cerevisiae の与えられた条件での増殖に必要だが欠落しているボトルネック因子を明らかにできる．これまでの研究では，実験室で人為的に構築したストレス環境でのボトルネックの同定を行ってきたが，本研究では産業上のボトルネックを明らかにできるかをワイン醸造用のブドウ果汁を例として検証した．通常のワイン醸造に用いられる亜硫酸添加ブドウ果汁でのADOPT 実験は，亜硫酸ポンプSSU1とその転写因子FZF1の過剰発現株が強く濃縮された．SSU1機能の強化はワイン用酵母の馴養でも起きることが知られていることから，産業上のボトルネックを探索する際にもADOPT が有効であることが示された．一方，亜硫酸添加のないブドウ果汁ではADOPT で強く濃縮された遺伝子は見られず，ブドウ果汁はS. cerevisiae の増殖にとってボトルネックの少ないバランスのとれた培地であることが示唆された．
kn-abstract=The authors have recently developed the overexpression profiling ADOPT method. In the ADOPT method, yeast strains overexpressing most of the genes in the budding yeast Saccharomyces cerevisiae genome are mixed and competitively cultured, and the genes overexpressed in the enriched strains are systematically identified. Furthermore, the identified genes can be used to identify bottleneck factors that are necessary but lacking for growth of S. cerevisiae under given conditions. In our previous studies, we have identified bottlenecks in artificially created stress environments in the laboratory, but in this study, we used grape juice for winemaking as an example to see if industrial bottlenecks can be identified. ADOPT experiments with sulfite-added grape juice used in conventional winemaking resulted in a strong enrichment of strains overexpressing the sulfite pump SSU1 and its transcription factor FZF1. Since enhancement of SSU1 function is known to occur in wine yeast acclimation, ADOPT was also shown to be useful in the search for industrial bottlenecks. On the other hand, no genes were strongly enriched by ADOPT in grape juice without sulfite addition, suggesting that grape juice is a balanced medium with few bottlenecks for S. cerevisiae growth.
en-copyright=
kn-copyright=

en-aut-name=MoriyaHisao
en-aut-sei=Moriya
en-aut-mei=Hisao
kn-aut-name=守屋央朗
kn-aut-sei=守屋
kn-aut-mei=央朗
aut-affil-num=1
ORCID=

en-aut-name=OnoChiyuki Kohata 
en-aut-sei=Ono
en-aut-mei=Chiyuki Kohata 
kn-aut-name=小野千由貴
kn-aut-sei=小野
kn-aut-mei=千由貴
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Course of Agrochemical Bioscience
kn-affil=農芸化学コース

affil-num=2
en-affil=Course of Agrochemical Bioscience
kn-affil=農芸化学コース
en-keyword=yeast
kn-keyword=yeast
en-keyword=S. cerevisiae
kn-keyword=S. cerevisiae
en-keyword=overexpression
kn-keyword=overexpression
en-keyword=wine making
kn-keyword=wine making
END

start-ver=1.4
cd-journal=joma
no-vol=142
cd-vols=
no-issue=
article-no=
start-page=106433
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202307
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=EpEX, the soluble extracellular domain of EpCAM, resists cetuximab treatment of EGFR-high head and neck squamous cell carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objectives: Cetuximab (Cmab) is a molecularly targeted monoclonal antibody drug for head and neck squamous cell carcinoma (HNSC), although cetuximab resistance is a serious challenge. Epithelial cell adhesion molecule (EpCAM) is an established marker for many epithelial tumors, while the soluble EpCAM extracellular domain (EpEX) functions as a ligand for epidermal growth factor receptor (EGFR). We investigated the expression of EpCAM in HNSC, its involvement in Cmab action, and the mechanism by which soluble EpEX activated EGFR and played key roles in Cmab resistance.<br>
Materials and methods: We first examined EPCAM expression in HNSCs and its clinical significance by searching gene expression array databases. We then examined the effects of soluble EpEX and Cmab on intracellular signaling and Cmab efficacy in HNSC cell lines (HSC-3 and SAS).<br>
Results: EPCAM expression was found to be enhanced in HNSC tumor tissues compared to normal tissues, and the enhancement was correlated with stage progression and prognosis. Soluble EpEX activated the EGFR-ERK signaling pathway and nuclear translocation of EpCAM intracellular domains (EpICDs) in HNSC cells. EpEX resisted the antitumor effect of Cmab in an EGFR expression-dependent manner.<br>
Conclusion: Soluble EpEX activates EGFR to increase Cmab resistance in HNSC cells. The EpEX-activated Cmab resistance in HNSC is potentially mediated by the EGFR-ERK signaling pathway and the EpCAM cleavage-induced nuclear translocation of EpICD. High expression and cleavage of EpCAM are potential biomarkers for predicting the clinical efficacy and resistance to Cmab.
en-copyright=
kn-copyright=

en-aut-name=UmemoriKoki
en-aut-sei=Umemori
en-aut-mei=Koki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=EguchiTakanori
en-aut-sei=Eguchi
en-aut-mei=Takanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KawaiHotaka
en-aut-sei=Kawai
en-aut-mei=Hotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakamuraTomoya
en-aut-sei=Nakamura
en-aut-mei=Tomoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OgawaTatsuo
en-aut-sei=Ogawa
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YoshidaKunihiro
en-aut-sei=Yoshida
en-aut-mei=Kunihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KanemotoHideka
en-aut-sei=Kanemoto
en-aut-mei=Hideka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SatoKohei
en-aut-sei=Sato
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ObataKyoichi
en-aut-sei=Obata
en-aut-mei=Kyoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=RyumonShoji
en-aut-sei=Ryumon
en-aut-mei=Shoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=YutoriHirokazu
en-aut-sei=Yutori
en-aut-mei=Hirokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KataseNaoki
en-aut-sei=Katase
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=OkuiTatsuo
en-aut-sei=Okui
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=NagatsukaHitoshi
en-aut-sei=Nagatsuka
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Dental Pharmacology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Oral Pathology and Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=13
en-affil=Department of Oral Pathology, Graduate School of Biomedical Sciences, Nagasaki University
kn-affil=

affil-num=14
en-affil=Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine
kn-affil=

affil-num=15
en-affil=Department of Oral Pathology and Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=16
en-affil=Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Cetuximab
kn-keyword=Cetuximab
en-keyword=epithelial cell adhesion molecule (EpCAM)
kn-keyword=epithelial cell adhesion molecule (EpCAM)
en-keyword=EpEX
kn-keyword=EpEX
en-keyword=EpICD
kn-keyword=EpICD
en-keyword=epidermal growth factor receptor (EGFR)
kn-keyword=epidermal growth factor receptor (EGFR)
en-keyword=Drug resistance
kn-keyword=Drug resistance
en-keyword=Head and neck squamous cell carcinoma (HNSC)
kn-keyword=Head and neck squamous cell carcinoma (HNSC)
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=
article-no=
start-page=1
end-page=12
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20231215
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=University Students’ Perceptions towards Teachers
kn-title=大学生が持つ大学教員イメージの検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SumiokaKyoko
en-aut-sei=Sumioka
en-aut-mei=Kyoko
kn-aut-name=住岡恭子
kn-aut-sei=住岡
kn-aut-mei=恭子
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=山内裕斗
kn-aut-sei=山内
kn-aut-mei=裕斗
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=瀧北文
kn-aut-sei=瀧北
kn-aut-mei=文
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=重藤彩伽
kn-aut-sei=重藤
kn-aut-mei=彩伽
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=河野穂波
kn-aut-sei=河野
kn-aut-mei=穂波
aut-affil-num=5
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野遥香
kn-aut-sei=小野
kn-aut-mei=遥香
aut-affil-num=6
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=島津柊
kn-aut-sei=島津
kn-aut-mei=柊
aut-affil-num=7
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=月輪花菜
kn-aut-sei=月輪
kn-aut-mei=花菜
aut-affil-num=8
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=草野結子
kn-aut-sei=草野
kn-aut-mei=結子
aut-affil-num=9
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=秋田美月
kn-aut-sei=秋田
kn-aut-mei=美月
aut-affil-num=10
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=石村竜大
kn-aut-sei=石村
kn-aut-mei=竜大
aut-affil-num=11
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=井上希美
kn-aut-sei=井上
kn-aut-mei=希美
aut-affil-num=12
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=坂田奈菜子
kn-aut-sei=坂田
kn-aut-mei=奈菜子
aut-affil-num=13
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=森崇人
kn-aut-sei=森
kn-aut-mei=崇人
aut-affil-num=14
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=森脇日菜子
kn-aut-sei=森脇
kn-aut-mei=日菜子
aut-affil-num=15
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=山本美玖
kn-aut-sei=山本
kn-aut-mei=美玖
aut-affil-num=16
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=

affil-num=3
en-affil=
kn-affil=

affil-num=4
en-affil=
kn-affil=

affil-num=5
en-affil=
kn-affil=

affil-num=6
en-affil=
kn-affil=

affil-num=7
en-affil=
kn-affil=

affil-num=8
en-affil=
kn-affil=

affil-num=9
en-affil=
kn-affil=

affil-num=10
en-affil=
kn-affil=

affil-num=11
en-affil=
kn-affil=

affil-num=12
en-affil=
kn-affil=

affil-num=13
en-affil=
kn-affil=

affil-num=14
en-affil=
kn-affil=

affil-num=15
en-affil=
kn-affil=

affil-num=16
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=10
article-no=
start-page=1730
end-page=1740
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20221027
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Lip pleomorphic adenomas: case series and literature review
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Pleomorphic adenoma (PA) is the most frequent benign salivary gland tumor, but a lip PA is rare. Although this tumor may be definitively diagnosed by imaging or a tissue biopsy if it is reasonably large, PAs on the lip are relatively small, and they present findings that are similar to those of other lip lesions, which can make a preoperative diagnosis difficult.<br>
Methods: We analyzed all PAs in the oral region and lesions on the lips treated in our department over the past 20 years, and we discuss them together with the relevant literature.<br>
Results: We found that 11.8% (n=6) of the PAs occurred on a lip (upper lip: 9.8%, lower lip: 2.0%), and ~1% of all mass lesions of the lips were PAs. The average size of the lip PAs was 1.5±0.7 cm (range, 0.7–2.2 cm). For preoperative diagnostic assistance, ultrasonography (US) (n=4), magnetic resonance (MR) (n=3), or no imaging (n=2) was used. An excisional biopsy was performed in all cases, and to date, no recurrence or malignant transformation has been observed.<br>
Conclusions: Lip PA is relatively rare. Because almost all of these lesions are small, a preoperative diagnosis is more difficult compared to palatal lesions. This tumor is also prone to long-term neglect and has the potential for recurrence and malignant transformation. It is thus necessary to perform an excision that includes the capsule and surrounding tissues, and careful postoperative follow-up should be continued.
en-copyright=
kn-copyright=

en-aut-name=UmemoriKoki
en-aut-sei=Umemori
en-aut-mei=Koki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KanemotoHideka
en-aut-sei=Kanemoto
en-aut-mei=Hideka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ObataKyoichi
en-aut-sei=Obata
en-aut-mei=Kyoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KawaiHotaka
en-aut-sei=Kawai
en-aut-mei=Hotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NakamuraTomoya
en-aut-sei=Nakamura
en-aut-mei=Tomoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakanoKeisuke
en-aut-sei=Nakano
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NagatsukaHitoshi
en-aut-sei=Nagatsuka
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=SasakiAkira
en-aut-sei=Sasaki
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Pleomorphic adenoma (PA)
kn-keyword=Pleomorphic adenoma (PA)
en-keyword=upper lip
kn-keyword=upper lip
en-keyword=lower lip
kn-keyword=lower lip
en-keyword=minor salivary gland tumor
kn-keyword=minor salivary gland tumor
en-keyword=case series
kn-keyword=case series
END

start-ver=1.4
cd-journal=joma
no-vol=49
cd-vols=
no-issue=
article-no=
start-page=15
end-page=29
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=『ダロウェイ夫人』の配色における考察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野和子
kn-aut-sei=小野
kn-aut-mei=和子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=15
article-no=
start-page=2745
end-page=2754
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Toughening of poly(ionic liquid)-based ion gels with cellulose nanofibers as a sacrificial network
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Ion gels have the potential to be used in a broad range of applications, such as in carbon dioxide separation membranes and soft electronics. However, their low mechanical strength limits their practical applications. In this study, we developed double-network (DN) ion gels composed of TEMPO-oxidized cellulose nanofibers with hydrophobic groups (TOCNF) and cross-linked poly[1-ethyl-3-vinylimidazolium bis(trifluoromethanesulfonyl)imide] (PC2im-TFSI) networks. The mechanical strength of the gel increased as the amount of TOCNF in the gels increased up to 6 wt%. Moreover, the fracture energy of the DN ion gels with 6 wt% TOCNF was found to be 19 times higher than that of the PC2im-TFSI single network (SN) ion gels. Cyclic stress-strain measurements of the DN gels showed that the loading energy on the gels dissipates owing to the destruction of the physically cross-linked TOCNF network in the gels. The DN ion gels also exhibited a high decomposition temperature of approximately 400 degrees C because of the thermal stability of all components. Additionally, the fracture energy of the TOCNF/poly(ionic liquid) (PIL) DN ion gel was two times higher than that of the silica nanoparticles/PIL DN ion gel developed in our previous study [Watanabe et al., Soft Matter, 2020, 16, 1572-1581]. This suggests that fiber-shaped nanomaterials are more effective than spherical nanomaterials in enhancing the mechanical properties of ion gels. These results show that TOCNF can be used to toughen PIL-based ion gels and hence broaden their applications.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OeEmiho
en-aut-sei=Oe
en-aut-mei=Emiho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MizutaniYuna
en-aut-sei=Mizutani
en-aut-mei=Yuna
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=55
cd-vols=
no-issue=
article-no=
start-page=119
end-page=139
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230327
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=“Gja1軍” in the Social-military System of the Tangut Empire―A Critical Analysis of the Tian Sheng Code Vol.4―
kn-title=西夏の「軍gja1」に関する一試論―西夏語文献『天盛禁令』巻4の条文に基づいて―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnoHiroko
en-aut-sei=Ono
en-aut-mei=Hiroko
kn-aut-name=小野裕子
kn-aut-sei=小野
kn-aut-mei=裕子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=9
article-no=
start-page=2146
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Craniomaxillofacial Fibrous Dysplasia Improved Cosmetic and Occlusal Problem by Comprehensive Treatment: A Case Report and Review of Current Treatments
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Fibrous dysplasia (FD) is a fibrous lesion of immature bone, with an incidence of 10-20% in the head and neck region. Most cases are monostotic, but when a lesion occurs on the maxillofacial region and spreads to the surrounding bone, it is classified as polyostotic, despite its localized occurrence. In some cases, surgical intervention is required to improve the cosmetic or functional disturbance of a FD in the maxillofacial region, but it is necessary to confirm symmetry of the maxillofacial region in real time, and a surgical support system is required to compensate. Furthermore, prosthetic intervention is considered when postoperative acquired defects occur or further cosmetic or occlusal function improvement is needed. A comprehensive approach by an oral surgeon and a maxillofacial prosthodontist is necessary for the successful treatment and rehabilitation of such patients. In this article, we describe the case of a craniomaxillofacial FD patient with facial asymmetry and denture incompatibility with improved quality of life measures by integrating surgical treatment using a navigation system and postoperative prosthetic rehabilitation. We also discuss recent diagnostic methods and treatment strategies for craniomaxillofacial FD in the literature.
en-copyright=
kn-copyright=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YoshiokaNorie
en-aut-sei=Yoshioka
en-aut-mei=Norie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KunisadaYuki
en-aut-sei=Kunisada
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NakamuraTomoya
en-aut-sei=Nakamura
en-aut-mei=Tomoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakamuraYuko
en-aut-sei=Nakamura
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ObataKyoichi
en-aut-sei=Obata
en-aut-mei=Kyoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MinagiShogo
en-aut-sei=Minagi
en-aut-mei=Shogo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SasakiAkira
en-aut-sei=Sasaki
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=fibrous dysplasia
kn-keyword=fibrous dysplasia
en-keyword=polyostotic
kn-keyword=polyostotic
en-keyword=craniomaxillofacial
kn-keyword=craniomaxillofacial
en-keyword=surgical
kn-keyword=surgical
en-keyword=prosthetic
kn-keyword=prosthetic
en-keyword=comprehensive treatment
kn-keyword=comprehensive treatment
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=8
article-no=
start-page=1320
end-page=1333
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220718
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Reproduction of the Antitumor Effect of Cisplatin and Cetuximab Using a Three-dimensional Spheroid Model in Oral Cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background/Aim: Cancer research has been conducted using cultured cells as part of drug discovery testing, but conventional two-dimensional culture methods are unable to reflect the complex tumor microenvironment. On the other hand, three-dimensional cultures have recently been attracting attention as in vitro models that more closely resemble the in vivo physiological environment. The purpose of this study was to establish a 3D culture method for oral cancer and to verify its practicality. <br>
Materials and Methods: Three-dimensional cultures were performed using several oral cancer cell lines. Western blotting was used for protein expression analysis of the collected cell masses (spheroids), and H-E staining was used for structural observation. The cultures were exposed to cisplatin and cetuximab and the morphological changes of spheroids over time and the expression changes of target proteins were compared. <br>
Results: Each cell line formed spheroidal cell aggregates and showed enhancement of cell adhesion molecules over time. H-E staining showed tumor tissue-like structures specific to each cell line. Cisplatin showed concentration-dependent antitumor effects due to loss of cell adhesion and spheroid disruption in each cell line, while cetuximab exhibited antitumor effects that correlated with EGFR expression in each cell line. <br>
Conclusion: Spheroids made from oral cancer cell lines appeared to have tumor-like characteristics that may reflect their clinical significance. In the future, it may become possible to produce tumor spheroids from tissue samples of oral cancer patients, and then apply them to drug screening and to develop individualized diagnostic and treatment methods.
en-copyright=
kn-copyright=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SatoKohei
en-aut-sei=Sato
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakamuraTomoya
en-aut-sei=Nakamura
en-aut-mei=Tomoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YoshidaYume
en-aut-sei=Yoshida
en-aut-mei=Yume
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MurataShogo
en-aut-sei=Murata
en-aut-mei=Shogo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YoshidaKunihiro
en-aut-sei=Yoshida
en-aut-mei=Kunihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KanemotoHideka
en-aut-sei=Kanemoto
en-aut-mei=Hideka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=UmemoriKoki
en-aut-sei=Umemori
en-aut-mei=Koki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KawaiHotaka
en-aut-sei=Kawai
en-aut-mei=Hotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ObataKyoichi
en-aut-sei=Obata
en-aut-mei=Kyoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=RyumonShoji
en-aut-sei=Ryumon
en-aut-mei=Shoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=HasegawaKazuaki
en-aut-sei=Hasegawa
en-aut-mei=Kazuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KunisadaYuki
en-aut-sei=Kunisada
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=OkuiTatsuo
en-aut-sei=Okui
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=NagatsukaHitoshi
en-aut-sei=Nagatsuka
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=SasakiAkira
en-aut-sei=Sasaki
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=13
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=14
en-affil=Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine
kn-affil=

affil-num=15
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=16
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=17
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=oral cancer
kn-keyword=oral cancer
en-keyword=spheroid
kn-keyword=spheroid
en-keyword=three-dimensional culture
kn-keyword=three-dimensional culture
en-keyword=anticancer drug
kn-keyword=anticancer drug
END

start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=3
article-no=
start-page=250
end-page=259
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220126
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Microfluidic Production of Monodisperse Biopolymer Microcapsules for Latent Heat Storage
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Microencapsulation of phase change materials in a polymer shell is a promising technology to prevent them from leakage and to use them as a handleable powder state. However, the microencapsulation process is a time-consuming process because the typical shell-forming step requires polymerization or evaporation of the solvent. In this study, we report a simple and rapid flow process to prepare monodisperse biocompatible cellulose acetate (CA) microcapsules encapsulating n-hexadecane (HD) for latent heat storage applications. The microcapsules were prepared by combining microfluidic droplet formation and subsequent rapid solvent removal from the droplets by solvent diffusion. The diameter and shell thickness of the microcapsules could be controlled by adjusting the flow rate and the HD-to-CA weight ratio in the dispersed phase. We found that 1-hexadecanol added to the microcapsules played the role of a nucleation agent and mitigated the supercooling phenomenon during crystallization. Furthermore, cross-linking of the CA shell with poly(propylene glycol), tolylene 2,4-diisocyanate terminated, resulted in the formation of a thin and dense shell. The microcapsules exhibited a 66 wt % encapsulation efficiency and a 176 J g–1 latent heat storage capacity, with negligible supercooling. We believe that this microflow process can contribute to the preparation of environmentally friendly microcapsules for heat storage applications.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SakaiYuko
en-aut-sei=Sakai
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SugimoriNaomi
en-aut-sei=Sugimori
en-aut-mei=Naomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IkedaToshinori
en-aut-sei=Ikeda
en-aut-mei=Toshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MonzenMasayuki
en-aut-sei=Monzen
en-aut-mei=Masayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Chusei Oil Co., Ltd.
kn-affil=

affil-num=4
en-affil=Chusei Oil Co., Ltd.
kn-affil=

affil-num=5
en-affil=Chusei Oil Co., Ltd.
kn-affil=

affil-num=6
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=microfluidics
kn-keyword=microfluidics
en-keyword=phase separation
kn-keyword=phase separation
en-keyword=core−shell
kn-keyword=core−shell
en-keyword=cellulose acetate
kn-keyword=cellulose acetate
en-keyword=latent heat storage
kn-keyword=latent heat storage
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=1
article-no=
start-page=e148960
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Resident stroma-secreted chemokine CCL2 governs myeloid-derived suppressor cells in the tumor microenvironment
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Accumulating evidence has shown that cancer stroma and BM-derived cells (BMDCs) in the tumor microenvironment (TME) play vital roles in tumor progression. However, the mechanism by which oral cancer stroma recruits any particular subset of BMDCs remains largely unknown. Here, we sought to identify the subset of BMDCs that is recruited by cancer stroma. We established a sequential transplantation model in BALB/c nude mice, including (a) BM transplantation of GFP-expressing cells and (b) coxenografting of patient-derived stroma (PDS; 2 cases, designated PDS1 and PDS2) with oral cancer cells (HSC-2). As controls, xenografting was performed with HSC-2 alone or in combination with normal human dermal fibroblasts (HDF). PDS1, PDS2, and HDF all promoted BMDC migration in vitro and recruitment in vivo. Multicolor immunofluorescence revealed that the PDS coxenografts recruited Arginase-1(+)CD11b(+)GR1(+)GFP(+) cells, which are myeloid-derived suppressor cells (MDSCs), to the TME, whereas the HDF coxenograft did not. Screening using microarrays revealed that PDS1 and PDS2 expressed CCL2 mRNA (encoding C-C motif chemokine ligand 2) at higher levels than did HDF. Indeed, PDS xenografts contained significantly higher proportions of CCL2(+) stromal cells and CCR2(+)Arginase-1(+)CD11b(+)GR1(+) MDSCs (as receiver cells) than the HDF coxenograft. Consistently, a CCL2 synthesis inhibitor and a CCR2 antagonist significantly inhibited the PDS-driven migration of BM cells in vitro. Furthermore, i.p. injection of the CCR2 antagonist to the PDS xenograft models significantly reduced the CCR2(+)Arginase-1(+)CD11b(+)GR1(+) MDSC infiltration to the TME. In conclusion, oral cancer stroma-secreted CCL2 is a key signal for recruiting CCR2(+) MDSCs from BM to the TME.
en-copyright=
kn-copyright=

en-aut-name=OoMay Wathone
en-aut-sei=Oo
en-aut-mei=May Wathone
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KawaiHotaka
en-aut-sei=Kawai
en-aut-mei=Hotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakabatakeKiyofumi
en-aut-sei=Takabatake
en-aut-mei=Kiyofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TomidaShuta
en-aut-sei=Tomida
en-aut-mei=Shuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=EguchiTakanori
en-aut-sei=Eguchi
en-aut-mei=Takanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ShanQiusheng
en-aut-sei=Shan
en-aut-mei=Qiusheng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OharaToshiaki
en-aut-sei=Ohara
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YoshidaSaori
en-aut-sei=Yoshida
en-aut-mei=Saori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OmoriHaruka
en-aut-sei=Omori
en-aut-mei=Haruka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SukegawaShintaro
en-aut-sei=Sukegawa
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=NakanoKeisuke
en-aut-sei=Nakano
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=OkamotoKuniaki
en-aut-sei=Okamoto
en-aut-mei=Kuniaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=SasakiAkira
en-aut-sei=Sasaki
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=NagatsukaHitoshi
en-aut-sei=Nagatsuka
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

affil-num=1
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Center for Comprehensive Genomic Medicine, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=13
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=14
en-affil=Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=15
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=1
article-no=
start-page=348
end-page=356
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20211222
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Multilayer Poly(ionic liquid) Microcapsules Prepared by Sequential Phase Separation and Subsequent Photopolymerization in Ternary Emulsion Droplets
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We report a simple microfluidic process to prepare multilayer poly(ionic liquid)s (PILs) microcapsules via sequential liquid-liquid phase separation within ternary emulsion droplets followed by the photopolymerization of ionic liquid (IL) monomerrich phases. The emulsion droplets, consisting of a hydrophobic IL monomer, water, and　N,N-dimethylformamide (DMF) are first formed in a microfluidic device, and the droplets are then carried by a continuous aqueous phase. Subsequently, DMF diffuses from the droplets into the continuous aqueous phase, resulting in the sequential internal phase separation of the IL-rich and water-rich phases, generating multilayer emulsion droplets comprising alternating IL-rich and water-rich phases. The number of droplet layers was controlled from one to five by varying the initial composition of the dispersed phase. Furthermore, in the conditions where higher-order emulsion droplets were formed, the time scale between the onset of phase separation and the formation of each layer became shorter. Additionally, the IL-rich phases in the multilayer emulsion droplets were easily solidified via photopolymerization, resulting in PILs microcapsules with multilayer structures. Anion exchange of the obtained PILs microcapsules effectuated their transition from a hydrophobic to a hydrophilic nature, resulting in PILs microcapsules with diverse swelling properties and PILs layers permeability across various solvents. We believe that the sequential phase separation system observed in the ternary emulsion droplets can pave the way for the design of PILs-based colloidal materials with thermodynamically non-equilibrium structures, thereby extending their application in functional materials.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YasuharaYuka
en-aut-sei=Yasuhara
en-aut-mei=Yuka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University, 3-1-1, Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
kn-affil=

affil-num=2
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University, 3-1-1, Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
kn-affil=

affil-num=3
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University, 3-1-1, Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
kn-affil=
en-keyword=Microfluidics
kn-keyword=Microfluidics
en-keyword=Multiple emulsion
kn-keyword=Multiple emulsion
en-keyword=Poly(ionic liquid)
kn-keyword=Poly(ionic liquid)
en-keyword=Phase separation
kn-keyword=Phase separation
en-keyword=Non-equilibrium structure
kn-keyword=Non-equilibrium structure
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=8
article-no=
start-page=1375
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210730
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Comparative Study on Epstein-Barr Virus-Positive Mucocutaneous Ulcer and Methotrexate-Associated Lymphoproliferative Disorders Developed in the Oral Mucosa: A Case Series of 10 Patients and Literature Review
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Methotrexate-associated lymphoproliferative disorder (MTX-LPD) is an iatrogenic immunodeficiency-associated lymphoproliferative disorder that occurs mainly with MTX use. This disorder has been associated with Epstein-Barr virus (EBV) infection. In 2017, the WHO newly defined the disease concept of EBV-positive mucocutaneous ulcer (EBV-MCU) as a good-prognosis EBV-related disease. Here, we report 10 cases of MTX-LPD or EBV-MCU in the oral mucosa. This retrospective, observational study was conducted with MTX-LPD or EBV-MCU in the oral mucosa patients who visited us during the nine year period from 2012 to 2021. We gathered the basic information, underlying disease, histopathological evaluation, treatment and prognosis for the subjects. All were being treated with MTX for rheumatoid arthritis. EBV infection was positive in all cases by immunohistochemistry. A complete or partial response was obtained in all cases with the withdrawal of MTX. Our results suggests that the most common risk factor for developing EBV-MCU is the use of immunosuppressive drugs. The most common site of onset is the oral mucosa, which may be attributed to the mode of EBV infection and the high incidence of chronic irritation of the oral mucosa. A small number of patients had been diagnosed with MTX-LPD, but we consider that these cases were EBV-MCU based on our study.
en-copyright=
kn-copyright=

en-aut-name=ObataKyoichi
en-aut-sei=Obata
en-aut-mei=Kyoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkuiTatsuo
en-aut-sei=Okui
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OnoSawako
en-aut-sei=Ono
en-aut-mei=Sawako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UmemoriKoki
en-aut-sei=Umemori
en-aut-mei=Koki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=RyumonShoji
en-aut-sei=Ryumon
en-aut-mei=Shoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YaoMayumi
en-aut-sei=Yao
en-aut-mei=Mayumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YoshiokaNorie
en-aut-sei=Yoshioka
en-aut-mei=Norie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=SasakiAkira
en-aut-sei=Sasaki
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine
kn-affil=

affil-num=3
en-affil=Department of Pathology, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Dentistry and Dental Surgery, Tsuyama Chuo Hospital
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=methotrexate
kn-keyword=methotrexate
en-keyword=lymphoproliferative disorders
kn-keyword=lymphoproliferative disorders
en-keyword=Epstein-Barr virus
kn-keyword=Epstein-Barr virus
en-keyword=mucocutaneous ulcer
kn-keyword=mucocutaneous ulcer
en-keyword=rheumatoid arthritis
kn-keyword=rheumatoid arthritis
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=6
article-no=
start-page=e04321
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210624
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A case of langerhans cell histiocytosis of the mandible that spontaneously regressed after biopsy in a child
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In younger patients of LCH, we should consider that the effectiveness of follow-up without aggressive treatment for SS-type LCH in the oral and maxillofacial bone. However, there are very rare case in which an SS-type LCH recurred after showing a healing tendency. Regular follow-up must be performed even after healing.
en-copyright=
kn-copyright=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkuiTatsuo
en-aut-sei=Okui
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KunisadaYuki
en-aut-sei=Kunisada
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ObataKyoichi
en-aut-sei=Obata
en-aut-mei=Kyoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MasuiMasanori
en-aut-sei=Masui
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=RyumonShoji
en-aut-sei=Ryumon
en-aut-mei=Shoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NakamuraTomoya
en-aut-sei=Nakamura
en-aut-mei=Tomoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SasakiAkira
en-aut-sei=Sasaki
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Oral and Maxillofacial Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=5
en-affil=Department of Oral and Maxillofacial Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=7
en-affil=Department of Oral and Maxillofacial Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=9
en-affil=Department of Oral and Maxillofacial Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=
en-keyword=dentistry
kn-keyword=dentistry
en-keyword=general surgery
kn-keyword=general surgery
en-keyword=oncology
kn-keyword=oncology
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=GPAMゲノム中におけるGPAM抑制のためのRBV応答性シスエレメントの同定
kn-title=Identification of ribavirin-responsive cis-elements for GPAM suppression in the GPAM genome
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnomuraDaichi
en-aut-sei=Onomura
en-aut-mei=Daichi
kn-aut-name=小野村大地
kn-aut-sei=小野村
kn-aut-mei=大地
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=6
cd-vols=
no-issue=15
article-no=
start-page=10030
end-page=10038
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210409
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Design of Clickable Ionic Liquid Monomers to Enhance Ionic Conductivity for Main-Chain 1,2,3-Triazolium-Based Poly(Ionic Liquid)s
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A series of clickable alpha-azide-omega-alkyne ionic liquid (IL) monomers with an ethylene oxide spacer were developed and applied to the synthesis of 1,2,3-triazolium-based poly(ionic liquid)s (TPILs) with high ionic conductivities via one-step thermal azide-alkyne cycloaddition click chemistry. Subsequently, the number of IL moieties in the resultant TPILs was further increased by N-alkylation of the 1,2,3-triazole-based backbones of the TPILs with a quarternizing reagent. This strategy affords the preparation of TPILs having either one or two 1,2,3-triazolium cations with bis(trifluoromethylsulfonyl)imide anions in a monomer unit. Synthesis of the TPILs was confirmed by H-1 and C-13 NMR spectroscopy and gel permeation chromatography. The effects of the length of the ethylene oxide spacer and the number of IL moieties in the IL monomer unit on the physicochemical properties of the TPILs were characterized by differential scanning calorimetry, thermogravimetric analysis, and impedance spectroscopy. The introduction of a longer ethylene oxide spacer or an increase in the number of IL moieties in the monomer unit resulted in TPILs with lower glass-transition temperatures and higher ionic conductivities. The highest ionic conductivity achieved in this study was 2.0 x 10(-5) S cm(-1) at 30 degrees C. These results suggest that the design of the IL monomer provides the resultant polymer with high chain flexibility and a high IL density, and so it is effective for preparing TPILs with high ionic conductivities.
en-copyright=
kn-copyright=

en-aut-name=HiraiRuka
en-aut-sei=Hirai
en-aut-mei=Ruka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=
article-no=
start-page=100330
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The HMGB1/RAGE axis induces bone pain associated with colonization of 4T1 mouse breast cancer in bone
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Bone pain is a common complication of breast cancer (BC) bone metastasis and is a major cause of increased morbidity and mortality. Although the mechanism of BC-associated bone pain (BCABP) remains poorly understood, involvement of BC products in the pathophysiology of BCABP has been proposed. Aggressive cancers secrete damage-associated molecular patterns (DAMPs) that bind to specific DAMP receptors and modulate cancer microenvironment. A prototypic DAMP, high mobility group box 1 (HMGB1), which acts as a ligand for the receptor for advanced glycation end products (RAGE) and toll-like receptors (TLRs), is increased in its expression in BC patients with poor outcomes. Here we show that 4T1 mouse BC cells colonizing bone up-regulate the expression of molecular pain markers, phosphorylated ERK1/2 (pERK) and pCREB, in the dorsal root ganglia (DRGs) innervating bone and induced BCABP as evaluated by hind-paw mechanical hypersensitivity. Importantly, silencing HMGB1 in 4T1 BC cells by shRNA reduced pERK and pCREB and BCABP with decreased HMGB1 levels in bone. Further, administration of a neutralizing antibody to HMGB1 or an antagonist for RAGE, FPS-ZM1, ameliorated pERK, pCREB and BCABP, while a TLR4 antagonist, TAK242, showed no effects. Consistent with these in vivo results, co-cultures of F11 sensory neuron-like cells with 4T1 BC cells in microfluidic culture platforms increased neurite outgrowth of F11 cells, which was blocked by HMGB1 antibody. Our results show that HMGB1 secreted by BC cells induces BCABP via binding to RAGE of sensory neurons and suggest that the HMGB1/RAGE axis may be a potential novel therapeutic target for BCABP.
en-copyright=
kn-copyright=

en-aut-name=OkuiTatsuo
en-aut-sei=Okui
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HiasaMasahiro
en-aut-sei=Hiasa
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=RyumonShoji
en-aut-sei=Ryumon
en-aut-mei=Shoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KunisadaYuki
en-aut-sei=Kunisada
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SasakiAkira
en-aut-sei=Sasaki
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=RoodmanG. David
en-aut-sei=Roodman
en-aut-mei=G. David
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=WhiteFletcher A.
en-aut-sei=White
en-aut-mei=Fletcher A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=YonedaToshiyuki
en-aut-sei=Yoneda
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=2
en-affil=Department of Biomaterials and Bioengineerings, University of Tokushima Graduate School of Dentistry
kn-affil=

affil-num=3
en-affil=
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=5
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=7
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=8
en-affil=Department of Medicine, Hematology Oncology, Indiana University School of Medicine
kn-affil=

affil-num=9
en-affil=Department of Anesthesia, Paul and Carole Stark Neurosciences Research Institute
kn-affil=

affil-num=10
en-affil=Department of Cellular and Molecular Biochemistry, Osaka University Graduate School of Dentistry
kn-affil=
en-keyword=Breast cancer
kn-keyword=Breast cancer
en-keyword=Bone pain
kn-keyword=Bone pain
en-keyword=Sensory neurons
kn-keyword=Sensory neurons
en-keyword=HMGB1
kn-keyword=HMGB1
en-keyword=RAGE 
kn-keyword=RAGE 
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=1
article-no=
start-page=1769373
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Triple knockdown of CDC37, HSP90‐alpha and HSP90‐beta diminishes extracellular vesicles‐driven malignancy events and macrophage M2 polarization in oral cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Evidence has been accumulating to indicate that extracellular vesicles (EVs), including exosomes, released by cancer cells can foster tumour progression. The molecular chaperones – CDC37, HSP90α and HSP90β play key roles in cancer progression including epithelial‐mesenchymal transition (EMT), although their contribution to EVs‐mediated cell–cell communication in tumour microenvironment has not been thoroughly examined. Here we show that triple depletion of the chaperone trio attenuates numerous cancer malignancy events exerted through EV release. Metastatic oral cancer‐derived EVs (MEV) were enriched with HSP90α HSP90β and cancer‐initiating cell marker CD326/EpCAM. Depletion of these chaperones individually induced compensatory increases in the other chaperones, whereas triple siRNA targeting of these molecules markedly diminished the levels of the chaperone trio and attenuated EMT. MEV were potent agents in initiating EMT in normal epithelial cells, a process that was attenuated by the triple chaperone depletion. The migration, invasion, and in vitro tumour initiation of oral cancer cells were significantly promoted by MEV, while triple depletion of CDC37/HSP90α/β reversed these MEV‐driven malignancy events. In metastatic oral cancer patient‐derived tumours, HSP90β was significantly accumulated in infiltrating tumour‐associated macrophages (TAM) as compared to lower grade oral cancer cases. HSP90‐enriched MEV‐induced TAM polarization to an M2 phenotype, a transition known to support cancer progression, whereas the triple chaperone depletion attenuated this effect. Mechanistically, the triple chaperone depletion in metastatic oral cancer cells effectively reduced MEV transmission into macrophages. Hence, siRNA‐mediated knockdown of the chaperone trio (CDC37/HSP90α/HSP90β) could potentially be a novel therapeutic strategy to attenuate several EV‐driven malignancy events in the tumour microenvironment.
en-copyright=
kn-copyright=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=Sogawa Chiharu
en-aut-sei=Sogawa
en-aut-mei= Chiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KawaiHotaka
en-aut-sei=Kawai
en-aut-mei=Hotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=Manh Tien Tran
en-aut-sei=Manh Tien Tran
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TahaEman A.
en-aut-sei=Taha
en-aut-mei=Eman A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=LuYanyin
en-aut-sei=Lu
en-aut-mei=Yanyin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=May Wathone Oo
en-aut-sei=May Wathone Oo
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OkushaYuka
en-aut-sei=Okusha
en-aut-mei=Yuka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OkamuraHirohiko
en-aut-sei=Okamura
en-aut-mei=Hirohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=TakigawaMasaharu
en-aut-sei=Takigawa
en-aut-mei=Masaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KozakiKen-Ichi
en-aut-sei=Kozaki
en-aut-mei=Ken-Ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=NagatsukaHitoshi
en-aut-sei=Nagatsuka
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=SasakiAkira
en-aut-sei=Sasaki
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=OkamotoKuniaki
en-aut-sei=Okamoto
en-aut-mei=Kuniaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=CalderwoodStuart K.
en-aut-sei=Calderwood
en-aut-mei=Stuart K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=EguchiTakanori
en-aut-sei=Eguchi
en-aut-mei=Takanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

affil-num=1
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Hospital
kn-affil=

affil-num=11
en-affil=Advanced Research Center for Oral and Craniofacial Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=13
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=14
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Hospital
kn-affil=

affil-num=15
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=16
en-affil=Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School
kn-affil=

affil-num=17
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Extracellular vesicles
kn-keyword=Extracellular vesicles
en-keyword=epithelial‐mesenchymal transition
kn-keyword=epithelial‐mesenchymal transition
en-keyword=tumour‐associated macrophage
kn-keyword=tumour‐associated macrophage
en-keyword=CDC37
kn-keyword=CDC37
en-keyword=HSP90
kn-keyword=HSP90
en-keyword=tetraspanin
kn-keyword=tetraspanin
en-keyword=oral cancer
kn-keyword=oral cancer
END

start-ver=1.4
cd-journal=joma
no-vol=50
cd-vols=
no-issue=
article-no=
start-page=179
end-page=197
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210127
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Institutional Mechanism of the Borderlands Patrol in the Tangut State: Reinterpretation of Tiansheng Code Vol.4
kn-title=西夏の巡検制度 : 『天盛旧改新定禁令』巻4「辺地巡検門」中の12条を中心に
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnoHiroko
en-aut-sei=Ono
en-aut-mei=Hiroko
kn-aut-name=小野裕子
kn-aut-sei=小野
kn-aut-mei=裕子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=62
article-no=
start-page=37743
end-page=37748
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20201013
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=One-pot synthesis of poly(ionic liquid)s with 1,2,3-triazolium-based backbones via clickable ionic liquid monomers
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Clickable α-azide-ω-alkyne ionic liquid monomers were developed and subsequently applied to the one-pot synthesis of ionically conducting poly(ionic liquid)s with 1,2,3-triazolium-based backbones through a click chemistry strategy. This approach does not require the use of solvents, polymerisation mediators, or catalysts. The obtained poly(ionic liquid)s were characterized by NMR, differential scanning calorimetry, thermogravimetric analysis, and impedance spectroscopy analysis. Moreover, these poly(ionic liquid)s were cross-linked via N-alkylation with a dianion quarternizing agent to achieve enhanced ionic conductivity and mechanical strength. The resulting free-standing films showed a Young's modulus up to 4.8 MPa and ionic conductivities up to 4.60 × 10−8 S cm−1 at 30 °C. This facile synthetic strategy has the potential to expand the availability of poly(ionic liquid)s and promote the development of functional materials.
en-copyright=
kn-copyright=

en-aut-name=HiraiRuka
en-aut-sei=Hirai
en-aut-mei=Ruka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HibinoTatsuki
en-aut-sei=Hibino
en-aut-mei=Tatsuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=44
cd-vols=
no-issue=6
article-no=
start-page=2547
end-page=2558
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20201002
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=High mobility group box 1 induces bone pain associated with bone invasion in a mouse model of advanced head and neck cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Advanced head and neck cancer (HNC) can invade facial bone and cause bone pain, thus posing a significant challenge to the quality of life of patients presenting with advanced HNC. The present study was designed to investigate HNC bone pain (HNC‑BP) in an intratibial mouse xenograft model that utilized an HNC cell line (SAS cells). These mice develop HNC‑BP that is associated with an expression of phosphorylated ERK1/2 (pERK1/2), which is a molecular indicator of neuron excitation in dorsal root ganglia (DRG) sensory neurons. Our experiments demonstrated that the inhibition of high mobility group box 1 (HMGB1) by short hairpin (shRNA) transduction, HMGB1 neutralizing antibody, and HMGB1 receptor antagonist suppressed the HNC‑BP and the pERK1/2 expression in DRG. It was also observed that HNC‑derived HMGB1 increased the expression of the acid‑sensing nociceptor, transient receptor potential vanilloid 1 (TRPV1), which is a major cause of osteoclastic HNC‑BP in DRG. Collectively, our results demonstrated that HMGB1 originating in HNC evokes HNC‑BP via direct HMGB1 signaling and hypersensitization for the acid environment in sensory neurons.
en-copyright=
kn-copyright=

en-aut-name=NakamuraTomoya
en-aut-sei=Nakamura
en-aut-mei=Tomoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkuiTatsuo
en-aut-sei=Okui
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HasegawaKazuaki
en-aut-sei=Hasegawa
en-aut-mei=Kazuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=RyumonShoji
en-aut-sei=Ryumon
en-aut-mei=Shoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KunisadaYuki
en-aut-sei=Kunisada
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ObataKyoichi
en-aut-sei=Obata
en-aut-mei=Kyoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MasuiMasanori
en-aut-sei=Masui
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ShimoTsuyoshi
en-aut-sei=Shimo
en-aut-mei=Tsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SasakiAkira
en-aut-sei=Sasaki
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science,
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=3
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=5
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=7
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=9
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=10
en-affil=Division of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
kn-affil=

affil-num=11
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=
en-keyword=head and neck cancer
kn-keyword=head and neck cancer
en-keyword=bone pain
kn-keyword=bone pain
en-keyword=HMGB1
kn-keyword=HMGB1
en-keyword=RAGE
kn-keyword=RAGE
en-keyword=sensory neuron
kn-keyword=sensory neuron
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=1
article-no=
start-page=180
end-page=184
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20201106
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Surgical resection of a giant peripheral ossifying fibroma in mouth floor managed with fiberscopic intubation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Tracheal intubation for general anesthesia can sometimes be difficult in patients with a large mass in the mouth floor. Preoperative evaluation of the patient's airway is most important when treating large oral disease.
en-copyright=
kn-copyright=

en-aut-name=OkuiTatsuo
en-aut-sei=Okui
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HasegawaKazuaki
en-aut-sei=Hasegawa
en-aut-mei=Kazuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SasakiAkira
en-aut-sei=Sasaki
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=peripheral ossifying fibroma
kn-keyword=peripheral ossifying fibroma
END

start-ver=1.4
cd-journal=joma
no-vol=531
cd-vols=
no-issue=3
article-no=
start-page=422
end-page=430
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20201020
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=High-mobility group box 1 induces bone destruction associated with advanced oral squamous cancer via RAGE and TLR4
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Bone destruction of maxillary and mandibular bone by invasive oral squamous cell cancer (OSCC) raises various problems in the management of patients, resulting in poor outcomes and survival. However, the mechanism behind bone destruction by OSCC remains unclear. High-mobility group box 1 (HMGB1), a highly conserved ubiquitous nuclear non-histone DNA-binding protein, has been demonstrated to be secreted by aggressive cancers and regulate osteoclastogenesis, a central player during bone destruction. We therefore reasoned that HMGB1 secreted by OSCCs contributes to bone destruction. Our results showed that HMGB1 is produced by human cell lines of OSCC and promotes osteoclastogenesis via up-regulation of the expression of receptor activator of nuclear factor kappa-Β ligand in osteoblasts and osteocytes, and consequently osteoclastic bone destruction in mice. Further, we found that these actions of HMGB1 are mediated via the receptor for advanced glycation end products and toll-like receptors. These findings suggest that HMGB1 of OSCC and its down-stream signal pathways are potential targets for the treatment of bone destruction associated with advanced OSCC.
en-copyright=
kn-copyright=

en-aut-name=SakamotoYumi
en-aut-sei=Sakamoto
en-aut-mei=Yumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkuiTatsuo
en-aut-sei=Okui
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YonedaToshiyuki
en-aut-sei=Yoneda
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=RyumonShoji
en-aut-sei=Ryumon
en-aut-mei=Shoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakamuraTomoya
en-aut-sei=Nakamura
en-aut-mei=Tomoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KawaiHotaka
en-aut-sei=Kawai
en-aut-mei=Hotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KunisadaYuki
en-aut-sei=Kunisada
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MasuiMasanori
en-aut-sei=Masui
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=ObataKyoichi
en-aut-sei=Obata
en-aut-mei=Kyoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=ShimoTsuyoshi
en-aut-sei=Shimo
en-aut-mei=Tsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=SasakiAkira
en-aut-sei=Sasaki
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=3
en-affil=Department of Cellular and Molecular Biochemistry, Osaka University Graduate School of Dentistry
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=5
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=6
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=9
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=10
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=11
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=12
en-affil=Division of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
kn-affil=

affil-num=13
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=
en-keyword=Oral squamous cell cancer
kn-keyword=Oral squamous cell cancer
en-keyword=HMGB1
kn-keyword=HMGB1
en-keyword=Bone destruction
kn-keyword=Bone destruction
en-keyword=Osteoclasts
kn-keyword=Osteoclasts
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=3
article-no=
start-page=47
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200305
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Novel Model of Cancer Drug Resistance: Oncosomal Release of Cytotoxic and Antibody-Based Drugs
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Extracellular vesicles (EVs), such as exosomes or oncosomes, often carry oncogenic molecules derived from tumor cells. In addition, accumulating evidence indicates that tumor cells can eject anti-cancer drugs such as chemotherapeutics and targeted drugs within EVs, a novel mechanism of drug resistance. The EV-releasing drug resistance phenotype is often coupled with cellular dedifferentiation and transformation in cells undergoing epithelial-mesenchymal transition (EMT), and the adoption of a cancer stem cell phenotype. The release of EVs is also involved in immunosuppression. Herein, we address different aspects by which EVs modulate the tumor microenvironment to become resistant to anticancer and antibody-based drugs, as well as the concept of the resistance-associated secretory phenotype (RASP).
en-copyright=
kn-copyright=

en-aut-name=EguchiTakanori
en-aut-sei=Eguchi
en-aut-mei=Takanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TahaEman Ahmed
en-aut-sei=Taha
en-aut-mei=Eman Ahmed
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=CalderwoodStuart K.
en-aut-sei=Calderwood
en-aut-mei=Stuart K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=喜章
kn-aut-sei=
kn-aut-mei=喜章
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Hospital
kn-affil=
en-keyword=extracellular vesicle (EV)
kn-keyword=extracellular vesicle (EV)
en-keyword=exosome
kn-keyword=exosome
en-keyword=oncosome
kn-keyword=oncosome
en-keyword=drug resistance
kn-keyword=drug resistance
en-keyword=epithelial-mesenchymal transition (EMT)
kn-keyword=epithelial-mesenchymal transition (EMT)
en-keyword=heat shock protein (HSP)
kn-keyword=heat shock protein (HSP)
en-keyword=cell stress response
kn-keyword=cell stress response
en-keyword=resistance-associated secretory phenotype (RASP)
kn-keyword=resistance-associated secretory phenotype (RASP)
en-keyword=hypoxia
kn-keyword=hypoxia
en-keyword=acidosis
kn-keyword=acidosis
en-keyword=tumor immunology
kn-keyword=tumor immunology
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=12
article-no=
start-page=2469
end-page=2475
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200730
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A case of oral cancer with delayed occipital lymph node metastasis: Case report
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Consideration of unexpected metastasis in patients who have undergone neck dissection with advanced tumors must be anticipated with careful follow-up.	
en-copyright=
kn-copyright=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YoshiokaNorie
en-aut-sei=Yoshioka
en-aut-mei=Norie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MasuiMasanori
en-aut-sei=Masui
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ObataKyoichi
en-aut-sei=Obata
en-aut-mei=Kyoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KunisadaYuki
en-aut-sei=Kunisada
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OkuiTatsuo
en-aut-sei=Okui
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KawaiHotaka
en-aut-sei=Kawai
en-aut-mei=Hotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NagatsukaHitoshi
en-aut-sei=Nagatsuka
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=SasakiAkira
en-aut-sei=Sasaki
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Oral and Maxillofacial Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=5
en-affil=Department of Oral and Maxillofacial Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Oral and Maxillofacial Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=7
en-affil=Department of Oral and Maxillofacial Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Oral Pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=9
en-affil=Department of Oral Pathology and Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=10
en-affil=Department of Oral and Maxillofacial Surgery, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=
en-keyword=delayed metastasis
kn-keyword=delayed metastasis
en-keyword=lymphatic regurgitation
kn-keyword=lymphatic regurgitation
en-keyword=neck dissection
kn-keyword=neck dissection
en-keyword=occipital lymph node
kn-keyword=occipital lymph node
en-keyword=oral cancer
kn-keyword=oral cancer
END

start-ver=1.4
cd-journal=joma
no-vol=220
cd-vols=
no-issue=9
article-no=
start-page=1900021
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190403
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Rapid Synthesis of Poly(methyl methacrylate) Particles with High Molecular Weight by Soap‐Free Emulsion Polymerization Using Water‐in‐Oil Slug Flow
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= flow process for the production of poly(methyl methacrylate) (PMMA) particles is proposed by soap‐free emulsion polymerization using a water‐in‐oil (W/O) slug flow in a microreactor. Thin oil films generated around the dispersed aqueous phase of the W/O slug prevent the prepared particles from adhesion to the microchannel wall, enabling the continuous production of PMMA particles without clogging. The effects of the linear flow rate of the slug flow and the addition of ethanol in the dispersed aqueous phase on the polymerization are evaluated. It is found that increasing the linear flow rate of the slug flow or the addition of ethanol in the dispersed aqueous phase results in PMMA particles with high molecular weight (≈1500 kg mol−1) in 20 min reaction time. It is believed that this process would be a promising way to prepare polymer particles with high molecular weight in a short reaction time.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KaritaKengo
en-aut-sei=Karita
en-aut-mei=Kengo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TawaraKoki
en-aut-sei=Tawara
en-aut-mei=Koki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SogaTakuya
en-aut-sei=Soga
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Material and Energy Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=heterogeneous polymerization
kn-keyword=heterogeneous polymerization
en-keyword=internal circulation
kn-keyword=internal circulation
en-keyword=microreactors
kn-keyword=microreactors
en-keyword=microspheres
kn-keyword=microspheres
END

start-ver=1.4
cd-journal=joma
no-vol=520
cd-vols=
no-issue=
article-no=
start-page=764
end-page=770
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170220
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Indocyanine green-laden poly(ethylene glycol)-block-polylactide (PEG-b-PLA) nanocapsules incorporating reverse micelles: Effects of PEG-b-PLA composition on the nanocapsule diameter and encapsulation efficiency
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Reverse micelles are thermodynamically stable systems, with a capacity to encapsulate hydrophilic molecules in their nanosized core, which is smaller than the core generally obtained with water-in-oil-emulsion droplets. Herein, we present a simple technique for the preparation of poly(ethylene glycol)-block-polylactide (PEG-b-PLA) nanocapsules encapsulating a hydrophilic photosensitizer (indocyanine green, ICG), which exploits reverse micelle formation and subsequent emulsion-solvent diffusion. We establish the effect of the PEG-b-PLA composition and the co-surfactant volume on the diameter and water content of the reverse micelles. We demonstrate that the composition of PEG-b-PLA affects also the diameter and encapsulation efficiency of the resulting nanocapsules. We show that the ICG-laden nanocapsules fabricated under the most optimal conditions have a diameter of approximately 100 nm and an ICG encapsulation efficiency of 58%. We believe that the method proposed here is a promising step towards the preparation of hydrophilic drug-laden polymer nanocapsules with a small diameter and therefore suitable for use in drug delivery applications based on enhanced permeability and retention (EPR) effect-driven passive targeting.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SakamotoYui
en-aut-sei=Sakamoto
en-aut-mei=Yui
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=InookaTetsuya
en-aut-sei=Inooka
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KimuraYukitaka
en-aut-sei=Kimura
en-aut-mei=Yukitaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Division of Material and Energy Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Division of Material and Energy Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=10
article-no=
start-page=4872
end-page=4877
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20131210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Monodisperse polylactide microcapsules with a single aqueous core prepared via spontaneous emulsification and solvent diffusion
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A simple approach to preparing monodisperse poly(D,L-lactide) (PDLLA) microcapsules with a single aqueous core is developed. The method is based on automatic water-in-oil-in-water double emulsion formation from oil-in-water single emulsion via spontaneous emulsification which voluntarily disperses part of continuous aqueous phase into the dispersed oil phase dissolving oil-soluble amphiphilic diblock copolymer, poly(D,L-lactide)-b-poly(2-dimethylaminoethyl methacylate)(PDLLA-b-PDMAEMA), followed by coalescence of tiny water droplets within the polymer droplets, coupled with quick precipitation of polymers by diluting the emulsion with water. In this study, we have investigated the effect of PDLLA to PDLLA-b-PDMAEMA ratios and flow rates of each solution during preparing the emulsion on the final morphology and the size of the microcapsules. It was found that the polymer blend ratio played a crucial role in determining internal structure of the microcapsules. The microcapsules size decreased with the increment of the flow rate ratios of the continuous phase to the dispersed phase and eventually reached 10 μm, while maintaining narrow size distribution. In addition, we have demonstrated that the microcapsules can encapsulate both hydrophilic and hydrophobic compounds during the formation.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KimuraYukitaka
en-aut-sei=Kimura
en-aut-mei=Yukitaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Material and Energy Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Applied Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=35
cd-vols=
no-issue=6
article-no=
start-page=2358
end-page=2367
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Microfluidic Formation of Hydrogel Microcapsules with a Single Aqueous Core by
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We report a simple process to fabricate monodisperse tetra-arm poly(ethylene glycol) (tetra-PEG) hydrogel microcapsules with an aqueous core and a semipermeable hydrogel shell through the formation of aqueous two-phase system (ATPS) droplets consisting of a dextran-rich core and a tetra-PEG macromonomer-rich shell, followed by a spontaneous cross-end coupling reaction of tetra-PEG macromonomers in the shell. Different from conventional techniques, this process enables for the continuous production of hydrogel microcapsules from water-in-oil emulsion droplets under mild conditions in the absence of radical initiators and external stimuli such as heating and ultraviolet light irradiation. We find that rapid cross-end coupling reaction of tetra-PEG macromonomers in ATPS droplets in the range of pH from 7.4 to 7.8 gives hydrogel microcapsules with a kinetically arrested core–shell structure. The diameter and core–shell ratio of the microcapsules can be easily controlled by adjusting flow rates and ATPS compositions. On the other hand, the slow cross-end coupling reaction of tetra-PEG macromonomers in ATPS droplets at pH 7.0 and lower induces structural change from core–shell to Janus during the reaction, which eventually forms hydrogel microparticles with a thermodynamically stable crescent structure. We believe that these hydrogel microparticles with controlled structures can be used in biomedical fields such as cell encapsulation, biosensors, and drug delivery carriers for sensitive biomolecules.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MotohiroIbuki
en-aut-sei=Motohiro
en-aut-mei=Ibuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Division of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=2
en-affil=Division of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=3
en-affil=Division of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=30
cd-vols=
no-issue=9
article-no=
start-page=2470
end-page=2479
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=2014029
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Microfluidic Approach to the Formation of Internally Porous Polymer Particles by Solvent Extraction
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We report the controlled formation of internally porous polyelectrolyte particles with diameters ranging from tens to hundreds of micrometers through selective solvent extraction using microfluidics. Solvent-resistant microdevices, fabricated by frontal photopolymerization, encapsulate binary polymer (P)/solvent (S1) mixtures by a carrier solvent phase (C) to form plugs with well-defined radii and low polydispersity; the suspension is then brought into contact with a selective extraction solvent (S2) that is miscible with C and S1 but not P, leading to the extraction of S1 from the droplets. The ensuing phase inversion yields polymer capsules with a smooth surface but highly porous internal structure. Depending on the liquid extraction time scale, this stage can be carried out in situ, within the chip, or ex situ, in an external S2 bath. Bimodal polymer plugs are achieved using asymmetrically inverted T junctions. For this demonstration, we form sodium poly(styrenesulfonate) (P) particles using water (S1), hexadecane (C), and methyl ethyl ketone (S2). We measure droplet extraction rates as a function of drop size and polymer concentration and propose a simple scaling model to guide particle formation. We find that the extraction time required to form particles from liquid droplets does not depend on the initial polymer concentration but is rather proportional to the initial droplet size. The resulting particle size follows a linear relationship with the initial droplet size for all polymer concentrations, allowing for the precise control of particle size. The internal particle porous structure exhibits a polymer density gradient ranging from a dense surface skin toward an essentially hollow core. Average particle porosities between 10 and 50% are achieved by varying the initial droplet compositions up to 15 wt % polymer. Such particles have potential applications in functional, optical, and coating materials.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=LopezCarlos G.
en-aut-sei=Lopez
en-aut-mei=Carlos G.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=DouglasJack F.
en-aut-sei=Douglas
en-aut-mei=Jack F.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=CabralJoão T.
en-aut-sei=Cabral
en-aut-mei=João T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil= Department of Chemical Engineering, Imperial College London
kn-affil=

affil-num=3
en-affil= Materials Science and Engineering Division, National Institute of Standards and Technology
kn-affil=

affil-num=4
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Chemical Engineering, Imperial College London
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=29
cd-vols=
no-issue=46
article-no=
start-page=14082
end-page=14088
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20131029
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Microfluidic Fabrication of Monodisperse Polylactide Microcapsules with Tunable Structures through Rapid Precipitation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We describe a versatile and facile route to the continuous production of monodisperse polylactide (PLA) microcapsules with controllable structures. With the combination of microfluidic emulsification, solvent diffusion, and internal phase separation, uniform PLA microcapsules with a perfluorooctyl bromide (PFOB) core were successfully obtained by simply diluting monodisperse ethyl acetate (EA)-in-water emulsion with pure water. Rapid extraction of EA from the droplets into the aqueous phase enabled the solidification of the polymer droplets in a nonequilibrium state during internal phase separation between a concentrated PLA/EA phase and a PFOB phase. Higher-molecular-weight PLA generated structural complexity of the microcapsules, yielding core–shell microcapsules with covered with small PFOB droplets. Removal of the PFOB via freeze drying gave hollow microcapsules with dimpled surfaces. The core–shell ratios and the diameter of these microcapsules could be finely tuned by just adjusting the concentration of PFOB and flow rates on emulsification, respectively. These biocompatible microcapsules with controllable size and structures are potentially applicable in biomedical fields such as drug delivery carriers of many functional molecules.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KimuraYukitaka
en-aut-sei=Kimura
en-aut-mei=Yukitaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Chemistry and Biotechnology, Graduate School of Natural Science and Technolog
kn-affil=

affil-num=2
en-affil=Department of Material and Energy Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Chemistry and Biotechnology, Graduate School of Natural Science and Technology
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=6
article-no=
start-page=1572
end-page=1581
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191223
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Preparation of tough, thermally stable, and water-resistant double-network ion gels consisting of silica nanoparticles/poly(ionic liquid)s through photopolymerisation of an ionic monomer and subsequent solvent removal
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We report the preparation of tough, thermally stable, and water-resistant double-network (DN) ion gels, which consist of a partially-clustered silica nanoparticle network and poly(ionic liquid) (PIL) network holding an ionic liquid. Silica nanoparticles/poly([Evim][Tf2N]) DN ion gels are prepared by photo-induced radical polymerisation of [Evim][Tf2N] in a mixture containing silica nanoparticles, [Bmim][Tf2N], ionic liquid based cross-linker [(VIM)2C4][Tf2N]2, and ethyl acetate, followed by subsequent solvent evaporation. Tensile strength measurements show that the mechanical properties of the PIL DN ion gels were higher than those of the PIL single-network (SN) ion gel. A rheological study indicates that an enhancement in mechanical strength of the PIL DN ion gels can be achieved when silica nanoparticles form partial clusters in [Bmim][Tf2N]. The cyclic stress–strain measurement of the PIL DN ion gels shows hysteresis loops, suggesting that the silica nanoparticle clusters rupture and dissipate the loading energy when the PIL DN ion gels undergo a large deformation. The fracture strength and Young's modulus of the PIL DN ion gels increase as the diameter of the silica nanoparticles is decreased. Thermogravimetric analysis measurement shows that the PIL DN ion gel has a high decomposition temperature of approximately 400 °C. Moreover, the swelling test shows that the PIL DN ion gel possesses an excellent water-resistant property because of the hydrophobic nature of the PIL backbone. We believe that such tough, thermally stable, and water-resistant PIL DN ion gels can be used as carbon dioxide separation membranes, sensors, and actuators for soft robotics.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakahashiRuri
en-aut-sei=Takahashi
en-aut-mei=Ruri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=21
article-no=
start-page=9894
end-page=9897
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110913
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Continuous fabrication of monodisperse polylactide microspheres by droplet-to-particle technology using microfluidic emulsification and emulsion–solvent diffusion
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Monodisperse polylactide (PLA) microspheres were continuously fabricated by microfluidic emulsification and subsequent dilution in water. The diameter was precisely tuned from 6 to 50 μm by changing the flow rate of the fluids in microfluidics or the PLA concentration in the dispersed phase. The use of amphiphilic oil-soluble poly(ethylene glycol)-b-polylactide (o-PEG–PLA) as a matrix resulted in a highly porous microsphere morphology, and the porosity was controlled by blending PLA. Therefore, monodisperse PLA microspheres with the predetermined surface porosity were continuously produced by just enough reagents and energy.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KimuraYukitaka
en-aut-sei=Kimura
en-aut-mei=Yukitaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Material and Energy Science, Graduate School of Environmental Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Material and Energy Science, Graduate School of Environmental Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Material and Energy Science, Graduate School of Environmental Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=298
cd-vols=
no-issue=
article-no=
start-page=1273
end-page=1281
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200717
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Flow synthesis of monodisperse micron-sized polymer particles by heterogeneous polymerization using a water-in-oil slug flow with a non-ionic surfactant
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Flow synthesis of poly(methyl methacrylate) particles was performed by heterogeneous polymerization of methyl methacrylate using a water-in-oil (W/O) slug flow with or without a non-ionic surfactant in the continuous organic phase. It was found that undesired phenomena in this polymerization system, clogging of the channel and broadening particle size distribution, can occur when growing polymer particles adsorb to the W/O interface during polymerization, and that the addition of non-ionic surfactant to the continuous organic phase prevents the particles from adsorption to the W/O interface and gives monodisperse polymer particles. In addition, it was shown that as the initiator concentration increases, the particle diameter becomes larger, resulting in monodisperse micron-sized polymer particles with 100% monomer conversion at a 120-min reaction time. These results indicated that the heterogeneous polymerization process using a W/O slug flow can be a promising way to continuously prepare monodisperse polymer particles with micron sizes in a short reaction time.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KaritaKengo
en-aut-sei=Karita
en-aut-mei=Kengo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=Microreactor
kn-keyword=Microreactor
en-keyword=Heterogeneous polymerization
kn-keyword=Heterogeneous polymerization
en-keyword=Slug flow
kn-keyword=Slug flow
en-keyword=Monodisperse
kn-keyword=Monodisperse
en-keyword=Micron-sized particle
kn-keyword=Micron-sized particle
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=4
article-no=
start-page=881
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200404
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Matrix metalloproteinase 3 (MMP3) plays multiple roles in extracellular proteolysis as well as intracellular transcription, prompting a new definition of moonlighting metalloproteinase (MMP), according to a definition of protein moonlighting (or gene sharing), a phenomenon by which a protein can perform more than one function. Indeed, connective tissue growth factor (CTGF, aka cellular communication network factor 2 (CCN2)) is transcriptionally induced as well as cleaved by MMP3. Moreover, several members of the MMP family have been found within tumor-derived extracellular vesicles (EVs). We here investigated the roles of MMP3-rich EVs in tumor progression, molecular transmission, and gene regulation. EVs derived from a rapidly metastatic cancer cell line (LuM1) were enriched in MMP3 and a C-terminal half fragment of CCN2/CTGF. MMP3-rich, LuM1-derived EVs were disseminated to multiple organs through body fluid and were pro-tumorigenic in an allograft mouse model, which prompted us to define LuM1-EVs as oncosomes in the present study. Oncosome-derived MMP3 was transferred into recipient cell nuclei and thereby trans-activated the CCN2/CTGF promoter, and induced CCN2/CTGF production in vitro. TRENDIC and other cis-elements in the CCN2/CTGF promoter were essential for the oncosomal responsivity. The CRISPR/Cas9-mediated knockout of MMP3 showed significant anti-tumor effects such as the inhibition of migration and invasion of tumor cells, and a reduction in CCN2/CTGF promoter activity and fragmentations in vitro. A high expression level of MMP3 or CCN2/CTGF mRNA was prognostic and unfavorable in particular types of cancers including head and neck, lung, pancreatic, cervical, stomach, and urothelial cancers. These data newly demonstrate that oncogenic EVs-derived MMP is a transmissive trans-activator for the cellular communication network gene and promotes tumorigenesis at distant sites.
en-copyright=
kn-copyright=

en-aut-name=OkushaYuka
en-aut-sei=Okusha
en-aut-mei=Yuka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=EguchiTakanori
en-aut-sei=Eguchi
en-aut-mei=Takanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TranManh T.
en-aut-sei=Tran
en-aut-mei=Manh T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SogawaChiharu
en-aut-sei=Sogawa
en-aut-mei=Chiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YoshidaKaya
en-aut-sei=Yoshida
en-aut-mei=Kaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ItagakiMami
en-aut-sei=Itagaki
en-aut-mei=Mami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TahaEman A.
en-aut-sei=Taha
en-aut-mei=Eman A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=AoyamaEriko
en-aut-sei=Aoyama
en-aut-mei=Eriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OkamuraHirohiko
en-aut-sei=Okamura
en-aut-mei=Hirohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KozakiKen-Ichi
en-aut-sei=Kozaki
en-aut-mei=Ken-Ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=CalderwoodStuart K.
en-aut-sei=Calderwood
en-aut-mei=Stuart K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=TakigawaMasaharu
en-aut-sei=Takigawa
en-aut-mei=Masaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=OkamotoKuniaki
en-aut-sei=Okamoto
en-aut-mei=Kuniaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Oral Healthcare Education, Institute of Biomedical Sciences, Tokushima University Graduate School
kn-affil=

affil-num=6
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Advanced Research Center for Oral and Craniofacial Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Oral Morphology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=11
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=12
en-affil=Division of Molecular and Cellular Biology, Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School
kn-affil=

affil-num=13
en-affil=Advanced Research Center for Oral and Craniofacial Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=14
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=matrix metalloproteinase
kn-keyword=matrix metalloproteinase
en-keyword=moonlighting metalloproteinase (MMP)
kn-keyword=moonlighting metalloproteinase (MMP)
en-keyword=protein moonlighting
kn-keyword=protein moonlighting
en-keyword=transcription factor
kn-keyword=transcription factor
en-keyword=extracellular vesicles
kn-keyword=extracellular vesicles
en-keyword=oncosome
kn-keyword=oncosome
en-keyword=genome editing
kn-keyword=genome editing
en-keyword=CRISPR
kn-keyword=CRISPR
en-keyword=cellular communication network factor
kn-keyword=cellular communication network factor
en-keyword=CCN2/CTGF 
kn-keyword=CCN2/CTGF 
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=
dt-pub=
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Aegilops cylindrica Host
kn-title=ヤギムギ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-keyword=イネ科 (Poaceae)
kn-keyword=イネ科 (Poaceae)
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=
dt-pub=
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Descurainia pinnata (Walter) Britton
kn-title=ヒメクジラグサ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-keyword=アブラナ科 (Brassicaceae)
kn-keyword=アブラナ科 (Brassicaceae)
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=小卵胞由来ブタ卵母細胞の成熟能及び初期発生能に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnoChiyuki
en-aut-sei=Ono
en-aut-mei=Chiyuki
kn-aut-name=小野千由貴
kn-aut-sei=小野
kn-aut-mei=千由貴
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=構造色発色システムを応用した新規コンポジットレジンの色調適合性に関する検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnoSerina
en-aut-sei=Ono
en-aut-mei=Serina
kn-aut-name=小野瀬里奈
kn-aut-sei=小野
kn-aut-mei=瀬里奈
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Porphyromonas gingivalisのPGN_0297変異株の作製とその性状解析：PGN_0297がジンジパイン活性に寄与している証拠
kn-title=Construction and characterization of a PGN_0297 mutant of Porphyromonas gingivalis: evidence of the contribution of PGN_0297 to gingipain activity
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnoShintaro
en-aut-sei=Ono
en-aut-mei=Shintaro
kn-aut-name=小野晋太郎
kn-aut-sei=小野
kn-aut-mei=晋太郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=上腕動脈の内膜中膜複合体肥厚は糖尿病患者の冠動脈の動脈硬化と関連する
kn-title=Brachial intima-media thickness is associated with coronary artery atherosclerosis in patients with diabetes mellitus
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnoTamaki
en-aut-sei=Ono
en-aut-mei=Tamaki
kn-aut-name=小野環
kn-aut-sei=小野
kn-aut-mei=環
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ポール側面衝突した車両の変形による吸収エネルギー推定を目的とした金属管によるモデル化の提案とその解析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnoTadanori
en-aut-sei=Ono
en-aut-mei=Tadanori
kn-aut-name=小野忠則
kn-aut-sei=小野
kn-aut-mei=忠則
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=細胞外小胞のHSPに富む特性は、転移性口腔癌細胞の生存を担う
kn-title=HSP-enriched properties of extracellular vesicles involve survival of metastatic oral cancer cells 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnoKisho
en-aut-sei=Ono
en-aut-mei=Kisho
kn-aut-name=小野喜章
kn-aut-sei=小野
kn-aut-mei=喜章
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180927
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Auslander-Reiten 原理と可換 DG 代数上のlifting の問題
kn-title=An Auslander-Reiten principle and a lifting problem over commutative DG algebras
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnoMaiko
en-aut-sei=Ono
en-aut-mei=Maiko
kn-aut-name=小野舞子
kn-aut-sei=小野
kn-aut-mei=舞子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=34
cd-vols=
no-issue=
article-no=
start-page=36
end-page=39
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=201804
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Deodorizing Effect of Weak Acid Hypochlorous Solution against Ammonia
kn-title=弱酸性次亜塩素酸水溶液のアンモニアに対する消臭効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The deodorizing effect of weak acid hypochlorous solution against ammonia was investigated. When atomized particles of weak acid hypochlorous solution contacted ammonia, the ammonia concentration decreased in a concentration-dependent manner. The deodorizing effect was also observed against ammonia generated from the used floor cover for mice. When the floor mat was present, the ammonia concentration gently decreased but then rapidly decreased when the floor mat was removed. In the future, we will examine effective spraying conditions for weak acid hypochlorous solution in laboratory animal facilities, and we will also proceed with the validation of effects other than spraying.
en-copyright=
kn-copyright=

en-aut-name=OnoTomoko
en-aut-sei=Ono
en-aut-mei=Tomoko
kn-aut-name=小野朋子
kn-aut-sei=小野
kn-aut-mei=朋子
aut-affil-num=1
ORCID=

en-aut-name=YamashitaKoji
en-aut-sei=Yamashita
en-aut-mei=Koji
kn-aut-name=山下光治
kn-aut-sei=山下
kn-aut-mei=光治
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Research and Technology Development Division，HSP company
kn-affil=株式会社エイチ・エス・ピー 研究開発部

affil-num=2
en-affil=Research and Technology Development Division，HSP company
kn-affil=株式会社エイチ・エス・ピー 研究開発部
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=口腔扁平上皮癌の発生と進展におけるYAPと⊿Np63の役割
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnoSawako
en-aut-sei=Ono
en-aut-mei=Sawako
kn-aut-name=小野早和子
kn-aut-sei=小野
kn-aut-mei=早和子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=129
cd-vols=
no-issue=2
article-no=
start-page=93
end-page=99
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The development of a scale to measure stress recognition during the treatment of diabetes patients
kn-title=糖尿病患者の「治療に伴うストレス認知尺度」の開発
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　The purpose of this study was to establish a measurement scale for "stress recognition in receiving treatment" in patients with diabetes. A self-completed questionnaire was distributed to 149 type-2 diabetes outpatients in March-May 2015 after authorization from Okayama Prefectural University and the ethics committee of the hospital.
　The "stress recognition in receiving treatment" scale was designed as a second-order factor model consisting of 14 items and the following four factors : the respondent's sense of  (1) the burden of being sick,  (2) the burden on interpersonal relationships, (3) the burden of treatment, and (4) the burden of medical expenses.
　Stress recognition in treatment means recognition of being stressed in the burdens related to the illness, interpersonal relationships, treatment and medical expenses.
　The suitability of the questionnaire data was then evaluated with a structural equation model. The suitability of the factor model to the data satisfied the statistically acceptable standards as Comparative Fit Index (CFI) ＝0.931, Root Mean Square Error of Approximation (RMSEA) ＝0.096, Tucker-Lewis Index (TLI) ＝0.946.
　As the construct validity was not examined by the scale created in this study or by existing scale, it was verified by using the degrees of mental healthiness and HbA1c that were proved to be associated with the sense of burden.
　In addition, the construct validity of the questionnaire was supported by a significant correlation between the Japanese version of the WHO-Five Well-being Index  (S-WHO-5-J) and the patients' HbA1c levels. The use of this measure is expected to contribute to the early detection of a decline in a diabetic patient's activities of daily living and to the early confirmation of patients' support status.
en-copyright=
kn-copyright=

en-aut-name=SumiyoshiKazuko
en-aut-sei=Sumiyoshi
en-aut-mei=Kazuko
kn-aut-name=住吉和子
kn-aut-sei=住吉
kn-aut-mei=和子
aut-affil-num=1
ORCID=

en-aut-name=KawataChieko
en-aut-sei=Kawata
en-aut-mei=Chieko
kn-aut-name=川田智恵子
kn-aut-sei=川田
kn-aut-mei=智恵子
aut-affil-num=2
ORCID=

en-aut-name=OkamotoTatsuo
en-aut-sei=Okamoto
en-aut-mei=Tatsuo
kn-aut-name=岡本辰夫
kn-aut-sei=岡本
kn-aut-mei=辰夫
aut-affil-num=3
ORCID=

en-aut-name=OhashiMutsuko
en-aut-sei=Ohashi
en-aut-mei=Mutsuko
kn-aut-name=大橋睦子
kn-aut-sei=大橋
kn-aut-mei=睦子
aut-affil-num=4
ORCID=

en-aut-name=MikaneSakae
en-aut-sei=Mikane
en-aut-mei=Sakae
kn-aut-name=實金栄
kn-aut-sei=實金
kn-aut-mei=栄
aut-affil-num=5
ORCID=

en-aut-name=TakabayashiNoriko
en-aut-sei=Takabayashi
en-aut-mei=Noriko
kn-aut-name=高林範子
kn-aut-sei=高林
kn-aut-mei=範子
aut-affil-num=6
ORCID=

en-aut-name=FutoyuYoshiko
en-aut-sei=Futoyu
en-aut-mei=Yoshiko
kn-aut-name=太湯好子
kn-aut-sei=太湯
kn-aut-mei=好子
aut-affil-num=7
ORCID=

en-aut-name=KimWoesook
en-aut-sei=Kim
en-aut-mei=Woesook
kn-aut-name=金外淑
kn-aut-sei=金
kn-aut-mei=外淑
aut-affil-num=8
ORCID=

en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=和田淳
kn-aut-sei=和田
kn-aut-mei=淳
aut-affil-num=9
ORCID=

en-aut-name=ShikataKenichi
en-aut-sei=Shikata
en-aut-mei=Kenichi
kn-aut-name=四方賢一
kn-aut-sei=四方
kn-aut-mei=賢一
aut-affil-num=10
ORCID=

en-aut-name=NakajimaKazuo
en-aut-sei=Nakajima
en-aut-mei=Kazuo
kn-aut-name=中嶋和夫
kn-aut-sei=中嶋
kn-aut-mei=和夫
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Faculty of Health and Welfare Science, Okayama Prefectural University
kn-affil=岡山県立大学　保健福祉学部

affil-num=2
en-affil=Health and Nursing Sciences Masters Program, Wakayama Medical University
kn-affil=和歌山県立医科大学　大学院保健看護学研究科

affil-num=3
en-affil=Ryobi General Research Institute of Community Care
kn-affil=両備地域ケア総合研究所

affil-num=4
en-affil=Department of Nursing, Okayama University Hospital
kn-affil=岡山大学病院 看護部

affil-num=5
en-affil=Faculty of Health and Welfare Science, Okayama Prefectural University
kn-affil=岡山県立大学　保健福祉学部

affil-num=6
en-affil=Faculty of Health and Welfare Science, Okayama Prefectural University
kn-affil=岡山県立大学　保健福祉学部

affil-num=7
en-affil=School of Health Science and Social Welfare, Kibi International University
kn-affil=吉備国際大学　保健医療福祉学部

affil-num=8
en-affil=College of Nursing Art and Science, University of Hyogo
kn-affil=兵庫県立大学　看護学部

affil-num=9
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学

affil-num=10
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=岡山大学病院　新医療研究開発センター

affil-num=11
en-affil=Ryobi General Research Institute of Community Care
kn-affil=両備地域ケア総合研究所
en-keyword=糖尿病患者 (diabetes patients)
kn-keyword=糖尿病患者 (diabetes patients)
en-keyword=治療 (treatment)
kn-keyword=治療 (treatment)
en-keyword=ストレス認知 (stress recognition)
kn-keyword=ストレス認知 (stress recognition)
en-keyword=尺度開発 (development of a scale)
kn-keyword=尺度開発 (development of a scale)
END

start-ver=1.4
cd-journal=joma
no-vol=313
cd-vols=
no-issue=1
article-no=
start-page=169
end-page=174
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201707
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=In vitro analysis of radioprotective effect of monoterpenes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Monoterpenes are naturally occurring hydrocarbons composed of two units of isoprenes. They exhibit antioxidant activity to scavenge reactive oxygen species, such as hydroxyl radicals. We investigated the potential of monoterpenes such as thymol, linalool, and menthol to act as radioprotectants. The proliferation of EL4 cells, a mouse lymphoma cell line, treated with linalool at a concentration of 500 μM or more was not affected by X-ray irradiation. Plasmid-nicking assay performed using formamidopyrimidine-DNA glycosylase showed that linalool prevented single strand breaks and oxidized purines on pUC19 plasmid DNA. These findings indicate that linalool has the ability to scavenge reactive oxygen species and is a potential radioprotector.
en-copyright=
kn-copyright=

en-aut-name=KudoKen-ichi
en-aut-sei=Kudo
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HanafusaTadashi
en-aut-sei=Hanafusa
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=Department of Radiation Research, Advanced Science Research CenterOkayama University
kn-affil=

affil-num=3
en-affil=Department of Radiation Research, Advanced Science Research CenterOkayama University
kn-affil=
en-keyword=Monoterpenes
kn-keyword=Monoterpenes
en-keyword= Linalool 
kn-keyword= Linalool 
en-keyword=X-ray irradiation
kn-keyword=X-ray irradiation
en-keyword= Reactive oxygen species
kn-keyword= Reactive oxygen species
en-keyword= SSB 
kn-keyword= SSB 
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=3
article-no=
start-page=219
end-page=226
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201706
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Immunological Impact of Chemotherapy on the Tumor Microenvironment of Oral Squamous Cell Carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment. We divided the patients into the group of neoadjuvant chemotherapy (NAC) patients (n=8) and the nNAC (without NAC) patient group (n=10). We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment. Decreased numbers of Tregs and PD-1-positive cells were observed in the NAC group. No significant difference was observed in the degree of immune-cell infiltration between the patient groups except for CD56 NK cells in the stroma and PD-1 cells in cancer nests. Eighty percent of the nNAC specimens showed intermediate-to-strong PD-L1 protein expression, whereas 75% of the NAC specimens showed down-regulation of the PD-L1 protein, indicating the effectiveness of the chemotherapeutic treatment before surgery.
en-copyright=
kn-copyright=

en-aut-name=TakakuraHiroaki
en-aut-sei=Takakura
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=DomaeShohei
en-aut-sei=Domae
en-aut-mei=Shohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SasakiAkira
en-aut-sei=Sasaki
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Radiation Research, Advanced Science Research Center, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=oral squamous cell carcinoma
kn-keyword=oral squamous cell carcinoma
en-keyword=programmed cell death 1 ligand-1
kn-keyword=programmed cell death 1 ligand-1
en-keyword=tumor microenvironment
kn-keyword=tumor microenvironment
en-keyword=neoadjuvant chemotherapy
kn-keyword=neoadjuvant chemotherapy
en-keyword=immunohistochemistry
kn-keyword=immunohistochemistry
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=乳がん患者が捉えた乳がんピアサポートプログラムの主観的評価：質的研究
kn-title=Subjective evaluation of a peer support program by women with breast cancer: a qualitative study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnoMiho
en-aut-sei=Ono
en-aut-mei=Miho
kn-aut-name=小野美穂
kn-aut-sei=小野
kn-aut-mei=美穂
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=128
cd-vols=
no-issue=3
article-no=
start-page=201
end-page=205
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20161201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Ectopic sebaceous glands in the esophagus that became evident over a three-year span
kn-title=3 年間の内視鏡所見の変化を観察できた食道異所性皮脂腺の1 例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= A 43-year-old Japanese woman was diagnosed with ectopic sebaceous glands in the esophagus by esophagogastroduodenoscopy and biopsy. At the age of 46, typical ectopic sebaceous glands were recognized in the upper esophagus, whereas yellowish white granules were faintly observed in the lower esophagus. Esophagogastroduodenoscopy examinations were repeated when she was 47 and again at 50 years old, and the lesions in the lower esophagus had become more evident over the ensuing 3 years. Esophageal ectopic sebaceous glands are relatively infrequent, and there have been few case reports describing the progression of the endoscopic features. We also report the clinical and endoscopic features of the five similar cases with pathologically proven ectopic sebaceous glands in the esophagus.
en-copyright=
kn-copyright=

en-aut-name=IwamuroMasaya
en-aut-sei=Iwamuro
en-aut-mei=Masaya
kn-aut-name=岩室雅也
kn-aut-sei=岩室
kn-aut-mei=雅也
aut-affil-num=1
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=岡田裕之
kn-aut-sei=岡田
kn-aut-mei=裕之
aut-affil-num=2
ORCID=

en-aut-name=HaradaKeita
en-aut-sei=Harada
en-aut-mei=Keita
kn-aut-name=原田馨太
kn-aut-sei=原田
kn-aut-mei=馨太
aut-affil-num=3
ORCID=

en-aut-name=KanzakiHiromitsu
en-aut-sei=Kanzaki
en-aut-mei=Hiromitsu
kn-aut-name=神崎洋光
kn-aut-sei=神崎
kn-aut-mei=洋光
aut-affil-num=4
ORCID=

en-aut-name=HoriKeisuke
en-aut-sei=Hori
en-aut-mei=Keisuke
kn-aut-name=堀圭介
kn-aut-sei=堀
kn-aut-mei=圭介
aut-affil-num=5
ORCID=

en-aut-name=KitaMasahide
en-aut-sei=Kita
en-aut-mei=Masahide
kn-aut-name=喜多雅英
kn-aut-sei=喜多
kn-aut-mei=雅英
aut-affil-num=6
ORCID=

en-aut-name=KawanoSeiji
en-aut-sei=Kawano
en-aut-mei=Seiji
kn-aut-name=川野誠司
kn-aut-sei=川野
kn-aut-mei=誠司
aut-affil-num=7
ORCID=

en-aut-name=KawaharaYoshiro
en-aut-sei=Kawahara
en-aut-mei=Yoshiro
kn-aut-name=河原祥朗
kn-aut-sei=河原
kn-aut-mei=祥朗
aut-affil-num=8
ORCID=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=田中健大
kn-aut-sei=田中
kn-aut-mei=健大
aut-affil-num=9
ORCID=

en-aut-name=YamamotoKazuhide
en-aut-sei=Yamamoto
en-aut-mei=Kazuhide
kn-aut-name=山本和秀
kn-aut-sei=山本
kn-aut-mei=和秀
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=3
en-affil=Department of Endoscopy, Okayama University Hospital
kn-affil=岡山大学病院　光学医療診療部

affil-num=4
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=5
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=7
en-affil=Department of Endoscopy, Okayama University Hospital
kn-affil=岡山大学病院　光学医療診療部

affil-num=8
en-affil=Department of Endoscopy, Okayama University Hospital
kn-affil=岡山大学病院　光学医療診療部

affil-num=9
en-affil=Department of Pathology, Okayama University Hospital
kn-affil=岡山大学病院　病理診断科 

affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学
en-keyword=食道異所性脂腺（ectopic sebaceous glands in the esophagus）
kn-keyword=食道異所性脂腺（ectopic sebaceous glands in the esophagus）
en-keyword=粘膜下腫瘍（submucosal tumor）
kn-keyword=粘膜下腫瘍（submucosal tumor）
en-keyword=食道黄色腫（esophageal xanthoma）
kn-keyword=食道黄色腫（esophageal xanthoma）
END

start-ver=1.4
cd-journal=joma
no-vol=128
cd-vols=
no-issue=3
article-no=
start-page=191
end-page=196
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20161201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Our experience with the significance of collaborative medical and dental surgeries at the Head and Neck Cancer Center, Okayama University Hospital
kn-title=岡山大学病院頭頸部がんセンターにおける医科歯科合同手術の現状解析とその意義
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　　We have been collaborating with head and neck surgeons, plastic surgeons and oral surgeons in surgeries for many patients with head and neck carcinomas（ especially oral carcinomas） since 2006（ fiscal year 2005）. The Head and Neck Cancer Center was established at Okayama University Hospital in 2012.
　This Center was the first of its kind at a national university hospital in Japan.
　At the Center, 174 operations on head and neck carcinomas and 96 reconstructive operations were performed in 2014（ fiscal year）.
　Medical and dental collaborative operations have been increasing almost every year since the 2005 fiscal year. There were 45 collaborative operations in the 2014 fiscal year, which included 30 cases of bone or metal plate reconstruction or plate reinforcement of the jaws.
　There were 76 medical and dental collaborative operations in the 7 years before the establishment of the Center, with a mean of 10.9 operations per year. Since the establishment of the Center, there have been 112 cases over 3 years with a mean of 37.3 operations per year. The number of surgeries has been markedly increased by the establishment of the Head and Neck Cancer Center.
en-copyright=
kn-copyright=

en-aut-name=MizukawaNobuyoshi
en-aut-sei=Mizukawa
en-aut-mei=Nobuyoshi
kn-aut-name=水川展吉
kn-aut-sei=水川
kn-aut-mei=展吉
aut-affil-num=1
ORCID=

en-aut-name=OnodaTomoo
en-aut-sei=Onoda
en-aut-mei=Tomoo
kn-aut-name=小野田友男
kn-aut-sei=小野田
kn-aut-mei=友男
aut-affil-num=2
ORCID=

en-aut-name=MatsumotoHiroshi
en-aut-sei=Matsumoto
en-aut-mei=Hiroshi
kn-aut-name=松本洋
kn-aut-sei=松本
kn-aut-mei=洋
aut-affil-num=3
ORCID=

en-aut-name=TakedaSeiko
en-aut-sei=Takeda
en-aut-mei=Seiko
kn-aut-name=武田斉子
kn-aut-sei=武田
kn-aut-mei=斉子
aut-affil-num=4
ORCID=

en-aut-name=NodaYouhei
en-aut-sei=Noda
en-aut-mei=Youhei
kn-aut-name=野田洋平
kn-aut-sei=野田
kn-aut-mei=洋平
aut-affil-num=5
ORCID=

en-aut-name=OnodaSatoshi
en-aut-sei=Onoda
en-aut-mei=Satoshi
kn-aut-name=小野田聡
kn-aut-sei=小野田
kn-aut-mei=聡
aut-affil-num=6
ORCID=

en-aut-name=FukushimaMai
en-aut-sei=Fukushima
en-aut-mei=Mai
kn-aut-name=福島麻衣
kn-aut-sei=福島
kn-aut-mei=麻衣
aut-affil-num=7
ORCID=

en-aut-name=TsumuraMunechika
en-aut-sei=Tsumura
en-aut-mei=Munechika
kn-aut-name=津村宗近
kn-aut-sei=津村
kn-aut-mei=宗近
aut-affil-num=8
ORCID=

en-aut-name=TakeuchiTetsuo
en-aut-sei=Takeuchi
en-aut-mei=Tetsuo
kn-aut-name=竹内哲男
kn-aut-sei=竹内
kn-aut-mei=哲男
aut-affil-num=9
ORCID=

en-aut-name=SugiyamaNarushi
en-aut-sei=Sugiyama
en-aut-mei=Narushi
kn-aut-name=杉山成史
kn-aut-sei=杉山
kn-aut-mei=成史
aut-affil-num=10
ORCID=

en-aut-name=KimataYoshihiro
en-aut-sei=Kimata
en-aut-mei=Yoshihiro
kn-aut-name=木股敬裕
kn-aut-sei=木股
kn-aut-mei=敬裕
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Departments of Oral and Maxillofacial Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital
kn-affil=岡山大学病院　頭頸部がんセンター， 顎口腔再建外科

affil-num=2
en-affil=Departments of Otorhinolaryngology, Head and Neck Surgery, Head and Neck Cancer Center, Okayama University Hospital
kn-affil=岡山大学病院　頭頸部がんセンター，耳鼻咽喉・頭頸部外科

affil-num=3
en-affil=Departments of Plastic and Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital
kn-affil=岡山大学病院　頭頸部がんセンター，形成外科

affil-num=4
en-affil=Departments of Oral and Maxillofacial Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital
kn-affil=岡山大学病院　頭頸部がんセンター，顎口腔再建外科

affil-num=5
en-affil=Departments of Otorhinolaryngology, Head and Neck Surgery, Head and Neck Cancer Center, Okayama University Hospital
kn-affil=岡山大学病院　頭頸部がんセンター，耳鼻咽喉・頭頸部外科

affil-num=6
en-affil=Departments of Plastic and Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital
kn-affil=岡山大学病院　頭頸部がんセンター，形成外科

affil-num=7
en-affil=Departments of Oral and Maxillofacial Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital
kn-affil=岡山大学病院　頭頸部がんセンター，顎口腔再建外科

affil-num=8
en-affil=Departments of Otorhinolaryngology, Head and Neck Surgery, Head and Neck Cancer Center, Okayama University Hospital
kn-affil=岡山大学病院　頭頸部がんセンター，耳鼻咽喉・頭頸部外科

affil-num=9
en-affil=Departments of Dental Laboratory, Head and Neck Cancer Center, Okayama University Hospital
kn-affil=岡山大学病院　頭頸部がんセンター，歯科技工室

affil-num=10
en-affil=Departments of Plastic and Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital
kn-affil=岡山大学病院　頭頸部がんセンター，形成外科

affil-num=11
en-affil=Departments of Plastic and Reconstructive Surgery, Head and Neck Cancer Center, Okayama University Hospital
kn-affil=岡山大学病院　頭頸部がんセンター，形成外科
en-keyword=頭頸部がん（head and neck carcinoma）
kn-keyword=頭頸部がん（head and neck carcinoma）
en-keyword=口腔がん（oral carcinoma）
kn-keyword=口腔がん（oral carcinoma）
en-keyword=頭頸部がんセンター（Head and Neck Cancer Center）
kn-keyword=頭頸部がんセンター（Head and Neck Cancer Center）
en-keyword=医科歯科合同手術（collaborative medical and dental surgeries）
kn-keyword=医科歯科合同手術（collaborative medical and dental surgeries）
en-keyword=顎骨再建（reconstructive operations of the jaw）
kn-keyword=顎骨再建（reconstructive operations of the jaw）
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=3
article-no=
start-page=205
end-page=211
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=201606
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Structure of a New Palatal Plate and the Artificial Tongue for Articulation Disorder in a Patient with Subtotal Glossectomy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A palatal augmentation prosthesis (PAP) is used to facilitate improvement in the speech and swallowing functions of patients with tongue resection or tongue movement disorders. However, a PAPʼs effect is limited in cases where articulation disorder is severe due to wide glossectomy and/or segmental mandibulectomy. In this paper, we describe speech outcomes of a patient with an articulation disorder following glossectomy and segmental mandibulectomy. We used a palatal plate (PP) based on a PAP, along with an artificial tongue (KAT). Speech improvement was evaluated by a standardized speech intelligibility test consisting of 100 syllables. The speech intelligibility score was significantly higher when the patient wore both the PP and KAT than when he wore neither (p＝0.013). The conversational intelligibility score was significantly improved with the PP and KAT than without PP and KAT (p＝0.024). These results suggest that speech function can be improved in patients with hard tissue defects with segmental mandibulectomy using both a PP and a KAT. The nature of the design of the PP and that of the KAT will allow these prostheses to address a wide range of tissue defects.
en-copyright=
kn-copyright=

en-aut-name=KozakiKen-ichi
en-aut-sei=Kozaki
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KawakamiShigehisa
en-aut-sei=Kawakami
en-aut-mei=Shigehisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KonishiTakayuki
en-aut-sei=Konishi
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OhtaKeiji
en-aut-sei=Ohta
en-aut-mei=Keiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YanoJitsuro
en-aut-sei=Yano
en-aut-mei=Jitsuro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OnodaTomoo
en-aut-sei=Onoda
en-aut-mei=Tomoo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MatsumotoHiroshi
en-aut-sei=Matsumoto
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MizukawaNobuyoshi
en-aut-sei=Mizukawa
en-aut-mei=Nobuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KimataYoshihiro
en-aut-sei=Kimata
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=NishizakiKazunori
en-aut-sei=Nishizaki
en-aut-mei=Kazunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=IidaSeiji
en-aut-sei=Iida
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=GofukuAkio
en-aut-sei=Gofuku
en-aut-mei=Akio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=AbeMasanobu
en-aut-sei=Abe
en-aut-mei=Masanobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=MinagiShogo
en-aut-sei=Minagi
en-aut-mei=Shogo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=Okayama Dream Speech Project
en-aut-sei=Okayama Dream Speech Project
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

affil-num=1
en-affil=Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Division of Physical Medicine and Rehabilitation, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Dental Laboratory Division, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Otolaryngology-Head and Neck Surgery Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Otolaryngology-Head and Neck Surgery Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=13
en-affil=Department of Computer Science, Okayama University
kn-affil=

affil-num=14
en-affil=Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=15
en-affil=
kn-affil=
en-keyword=palatal augmentation prosthesis
kn-keyword=palatal augmentation prosthesis
en-keyword=artificial tongue
kn-keyword=artificial tongue
en-keyword=articulation disorder
kn-keyword=articulation disorder
en-keyword=glossectomy
kn-keyword=glossectomy
en-keyword=mandibulectomy
kn-keyword=mandibulectomy
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ラット実験モデルを用いたリンパ管静脈吻合術後の組織学的検討：開存例と閉塞例の比較
kn-title=Histological Evaluation of Lymphaticovenular Anastomosis Outcomes in the Rat Experimental Model: Comparison of Cases with Patency and Obstruction
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnodaSatoshi
en-aut-sei=Onoda
en-aut-mei=Satoshi
kn-aut-name=小野田聡
kn-aut-sei=小野田
kn-aut-mei=聡
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=127
cd-vols=
no-issue=3
article-no=
start-page=219
end-page=222
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20151201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Drug-induced liver injury due to the long-term oral administration of rosuvastatin
kn-title=長期のロスバスタチンカルシウム服用にて発症したと考えられる薬物性肝障害の一例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 67-year-old man was admitted to our hospital presenting with a liver injury. He had used several types of oral medication for the prior 2 years, including rosuvastatin calcium for hypertension, hyperlipidemia, and prostatic hypertrophy. His liver dysfunction was noted for the first time in February 2013, and at re-examination in March 2013 he showed exacerbation of the liver dysfunction, he was admitted to our hospital at that time. We stopped all of his oral medications, and his liver function improved steadily. We conducted a drug-induced lymphocyte transformation test (DLST), and the rosuvastatin calcium result was positive. He was diagnosed as having a drug-induced (by rosvastatin calcium) liver injury. He resumed oral medications other than rosuvastatin calcium from the time of discharge, with no exacerbation of liver dysfunction since then. Reports of drug-induced liver injury due to drugs with a long-term oral administration are extremely rare. We discuss the relevant literature herein.
en-copyright=
kn-copyright=

en-aut-name=OonishiAyano
en-aut-sei=Oonishi
en-aut-mei=Ayano
kn-aut-name=大西理乃
kn-aut-sei=大西
kn-aut-mei=理乃
aut-affil-num=1
ORCID=

en-aut-name=KariyamaKazuya
en-aut-sei=Kariyama
en-aut-mei=Kazuya
kn-aut-name=狩山和也
kn-aut-sei=狩山
kn-aut-mei=和也
aut-affil-num=2
ORCID=

en-aut-name=WakutaAkiko
en-aut-sei=Wakuta
en-aut-mei=Akiko
kn-aut-name=湧田暁子
kn-aut-sei=湧田
kn-aut-mei=暁子
aut-affil-num=3
ORCID=

en-aut-name=NishimuraMamoru
en-aut-sei=Nishimura
en-aut-mei=Mamoru
kn-aut-name=西村守
kn-aut-sei=西村
kn-aut-mei=守
aut-affil-num=4
ORCID=

en-aut-name=NousoKazuhiro
en-aut-sei=Nouso
en-aut-mei=Kazuhiro
kn-aut-name=能祖一裕
kn-aut-sei=能祖
kn-aut-mei=一裕
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山市立市民病院

affil-num=2
en-affil=
kn-affil=岡山市立市民病院

affil-num=3
en-affil=
kn-affil=岡山市立市民病院

affil-num=4
en-affil=
kn-affil=岡山市立市民病院

affil-num=5
en-affil=
kn-affil=岡山市立市民病院
en-keyword=薬物性肝障害（drug induced liver injury）
kn-keyword=薬物性肝障害（drug induced liver injury）
en-keyword=ロスバスタチンカルシウム（Rosuvastatin）
kn-keyword=ロスバスタチンカルシウム（Rosuvastatin）
en-keyword=スタチン（statin）
kn-keyword=スタチン（statin）
en-keyword=DLST
kn-keyword=DLST
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150620
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Adsorption and removal of strontium in aqueous solution by synthetic hydroxyapatite
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Hydroxyapatite (HAP) is a main mineral constituent of bone and tooth and has an outstanding biocompatibility. HAP is a possible sorbent for heavy metals in wastewater due to its high adsorption capacity and low water solubility. We developed a removal system of 90Sr from aqueous solution by HAP column procedure. More than 90 % of 90Sr was adsorbed and removed from the 90Sr containing solution. Divalent cations, Ca2+, had little effect on the removal of 90Sr up to a concentration of 1 mmol L−1. This clearly indicates that the HAP column technique is advantageous with respect to the capacity to adsorb 90Sr from water present in the environment.
en-copyright=
kn-copyright=

en-aut-name=NishiyamaYuichi
en-aut-sei=Nishiyama
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HanafusaTadashi
en-aut-sei=Hanafusa
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamashitaJun
en-aut-sei=Yamashita
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YamamotoYoko
en-aut-sei=Yamamoto
en-aut-mei=Yoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Radiation Research, Advanced Science Research Center, Okayama University

affil-num=2
en-affil=
kn-affil=Department of Radiation Research, Advanced Science Research Center, Okayama University

affil-num=3
en-affil=
kn-affil=Institute of Plant Science and Resources, Okayama University

affil-num=4
en-affil=
kn-affil=Institute of Plant Science and Resources, Okayama University

affil-num=5
en-affil=
kn-affil=Department of Radiation Research, Advanced Science Research Center, Okayama University
en-keyword=Strontium
kn-keyword=Strontium
en-keyword=Hydroxyapatite
kn-keyword=Hydroxyapatite
en-keyword=Adsorption
kn-keyword=Adsorption
en-keyword=Desorption
kn-keyword=Desorption
en-keyword=Divalent cation
kn-keyword=Divalent cation
END

start-ver=1.4
cd-journal=joma
no-vol=31
cd-vols=
no-issue=
article-no=
start-page=33
end-page=36
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=201504
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Environmental Disinfection by Hypochlorous Acid Solution
kn-title=次亜塩素酸水溶液による環境消毒について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Weak Acid Hypochlorous Solution (WAHS) has been used for disinfection of foods (meats, vegetables etc.), and for environmental disinfection in the Retirement homes, Hospitals and Laboratory Animal facilities. We will introduce here some of environmental disinfection tests. 1) To study whether WAHS is available or not for blood
blot inoculated by Acinetobacter baumannii on the plate comparing with Sodium Hypochlorite. 2) Comparison of Ethanol and WAHS on the floor and handrail. 3) To study efficacy of shallowly dipping by WAHS on wagon caster inoculated by Staphylococcus aureus.
The results are: 1) It was observed that WAHS had an efficacy equal to Hypochlorite with lower concentration in the blood test, but in case that the adhesion amount of blood was larger, much higher concentration or adding
physical removal was needed. 2) Ethanol and WAHS had Equivalent efficacy on the test of floor and handrail. 3) It was suggested that shallowly dipping by WAHS was available for disinfection of wagon caster. We hope to proceed to confirm how to use WAHS for environmental disinfection.
en-copyright=
kn-copyright=

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en-aut-sei=Yamashita
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aut-affil-num=1
ORCID=

en-aut-name=HamamotoYuji
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ORCID=

en-aut-name=YasudaYuto
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ORCID=

en-aut-name=OnoTomoko
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kn-aut-sei=小野
kn-aut-mei=朋子
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=株式会社 エイチ・エス・ピー

affil-num=2
en-affil=
kn-affil=株式会社 エイチ・エス・ピー

affil-num=3
en-affil=
kn-affil=株式会社 エイチ・エス・ピー

affil-num=4
en-affil=
kn-affil=株式会社 エイチ・エス・ピー
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20141231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=トポイソメラーゼ IIβのC末端ドメインへRNAが結合することにより酵素の核内動態と酵素活性が制御されている
kn-title=Nuclear dynamics of topoisomerase IIβ reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnodaAkihisa
en-aut-sei=Onoda
en-aut-mei=Akihisa
kn-aut-name=小野田彰久
kn-aut-sei=小野田
kn-aut-mei=彰久
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=2型糖尿病における微量アルブミン尿の寛解・改善に寄与する因子
kn-title=Factors Associated with Remission and/or Regression of Microalbuminuria in Type 2 Diabetes Mellitus
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnoTetsuichiro
en-aut-sei=Ono
en-aut-mei=Tetsuichiro
kn-aut-name=小野哲一郎
kn-aut-sei=小野
kn-aut-mei=哲一郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=126
cd-vols=
no-issue=1
article-no=
start-page=59
end-page=63
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Drug interaction (29. drug interaction of steroids)
kn-title=薬物相互作用(29―ステロイドの薬物相互作用）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HayashiYouko
en-aut-sei=Hayashi
en-aut-mei=Youko
kn-aut-name=林瑶子
kn-aut-sei=林
kn-aut-mei=瑶子
aut-affil-num=1
ORCID=

en-aut-name=NawaHideki
en-aut-sei=Nawa
en-aut-mei=Hideki
kn-aut-name=名和秀起
kn-aut-sei=名和
kn-aut-mei=秀起
aut-affil-num=2
ORCID=

en-aut-name=KitamuraYoshihisa
en-aut-sei=Kitamura
en-aut-mei=Yoshihisa
kn-aut-name=北村佳久
kn-aut-sei=北村
kn-aut-mei=佳久
aut-affil-num=3
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=千堂年昭
kn-aut-sei=千堂
kn-aut-mei=年昭
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学病院　薬剤部

affil-num=2
en-affil=
kn-affil=岡山大学病院　薬剤部

affil-num=3
en-affil=
kn-affil=岡山大学病院　薬剤部

affil-num=4
en-affil=
kn-affil=岡山大学病院　薬剤部
END

start-ver=1.4
cd-journal=joma
no-vol=126
cd-vols=
no-issue=1
article-no=
start-page=17
end-page=24
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Concept and management of pancreaticobiliary maljunction
kn-title=膵・胆管合流異常症―その概念と治療―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NodaTakuo
en-aut-sei=Noda
en-aut-mei=Takuo
kn-aut-name=野田卓男
kn-aut-sei=野田
kn-aut-mei=卓男
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学病院　小児外科
en-keyword=膵・胆管合流異常
kn-keyword=膵・胆管合流異常
en-keyword=先天性胆道拡張症
kn-keyword=先天性胆道拡張症
en-keyword=分流手術胆道癌
kn-keyword=分流手術胆道癌
END

start-ver=1.4
cd-journal=joma
no-vol=6
cd-vols=
no-issue=
article-no=
start-page=27
end-page=34
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1999
dt-pub=19990612
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=「生きる力」を育成する数学の授業改善を目指して 中学校の数学学力診断調査の問題の検討と考察 ―「数と式」を中心に―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=高橋敏雄
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ORCID=

en-aut-name=
en-aut-sei=
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kn-aut-name=黒崎東洋郎
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ORCID=

en-aut-name=
en-aut-sei=
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ORCID=

en-aut-name=
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en-aut-name=
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ORCID=

en-aut-name=
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en-aut-name=
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en-aut-name=
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en-aut-name=
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ORCID=

en-aut-name=
en-aut-sei=
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kn-aut-name=山本真道
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ORCID=

en-aut-name=
en-aut-sei=
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kn-aut-name=景山勝
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ORCID=

en-aut-name=
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kn-aut-name=小林武則
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ORCID=

en-aut-name=
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ORCID=

en-aut-name=
en-aut-sei=
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ORCID=

en-aut-name=
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kn-aut-name=林俊雄
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ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=村上有希子
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ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=佐官尚宏
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ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学教育学部

affil-num=2
en-affil=
kn-affil=岡山大学教育学部

affil-num=3
en-affil=
kn-affil=岡山理科大学

affil-num=4
en-affil=
kn-affil=岡山大学教育学部附属中学校

affil-num=5
en-affil=
kn-affil=岡山大学教育学部附属中学校

affil-num=6
en-affil=
kn-affil=岡山大学教育学部附属中学校

affil-num=7
en-affil=
kn-affil=岡山市立中山中学校

affil-num=8
en-affil=
kn-affil=岡山市立吉備中学校

affil-num=9
en-affil=
kn-affil=岡山市立富山中学校

affil-num=10
en-affil=
kn-affil=岡山市立桑田中学校

affil-num=11
en-affil=
kn-affil=倉敷市立東陽中学校

affil-num=12
en-affil=
kn-affil=倉敷市立多津美中学校

affil-num=13
en-affil=
kn-affil=倉敷市立琴浦中学校

affil-num=14
en-affil=
kn-affil=倉敷市立庄中学校

affil-num=15
en-affil=
kn-affil=玉野市立宇野中学校

affil-num=16
en-affil=
kn-affil=灘崎町立灘崎中学校

affil-num=17
en-affil=
kn-affil=御津町立御津中学校
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=
article-no=
start-page=13
end-page=21
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2000
dt-pub=20000610
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=「生きる力」を育成する中学校数学「数量関係」に関する学力診断調査問題の考察
en-subtitle=
kn-subtitle=
en-abstract=
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kn-copyright=

en-aut-name=
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kn-aut-name=高橋敏雄
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ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=黒崎東洋郎
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ORCID=

en-aut-name=
en-aut-sei=
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kn-aut-name=洲脇史郎
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ORCID=

en-aut-name=
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ORCID=

en-aut-name=
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ORCID=

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en-aut-name=
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ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学教育学部

affil-num=2
en-affil=
kn-affil=岡山大学教育学部

affil-num=3
en-affil=
kn-affil=岡山理科大学

affil-num=4
en-affil=
kn-affil=岡山大学教育学部附属中学校

affil-num=5
en-affil=
kn-affil=岡山大学教育学部附属中学校

affil-num=6
en-affil=
kn-affil=倉敷市立南中学校

affil-num=7
en-affil=
kn-affil=岡山市立中山中学校

affil-num=8
en-affil=
kn-affil=岡山市立上南中学校

affil-num=9
en-affil=
kn-affil=灘崎町立灘崎中学校

affil-num=10
en-affil=
kn-affil=玉野市立宇野中学校

affil-num=11
en-affil=
kn-affil=岡山市立富山中学校
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=
article-no=
start-page=1
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dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2001
dt-pub=20010609
dt-online=
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en-subject=
kn-subject=
en-title=
kn-title=「生きる力」を育成する中学校数学授業改善を目指して 中学校数学「図形」に関する学力診断調査問題の考察
en-subtitle=
kn-subtitle=
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ORCID=

en-aut-name=
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kn-aut-name=黒崎東洋郎
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ORCID=

en-aut-name=
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ORCID=

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ORCID=

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ORCID=

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en-aut-name=
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ORCID=

en-aut-name=
en-aut-sei=
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ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学教育学部

affil-num=2
en-affil=
kn-affil=岡山大学教育学部

affil-num=3
en-affil=
kn-affil=岡山理科大学理学部

affil-num=4
en-affil=
kn-affil=岡山大学教育学部附属中学校

affil-num=5
en-affil=
kn-affil=岡山大学教育学部附属中学校

affil-num=6
en-affil=
kn-affil=岡山大学教育学部附属中学校

affil-num=7
en-affil=
kn-affil=岡山市立中山中学校

affil-num=8
en-affil=
kn-affil=児島郡灘崎町立灘崎中学校

affil-num=9
en-affil=
kn-affil=玉野市立宇野中学校

affil-num=10
en-affil=
kn-affil=岡山市立上南中学校

affil-num=11
en-affil=
kn-affil=岡山市立富山中学校
END

start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=2
article-no=
start-page=163
end-page=167
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130801
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en-subject=
kn-subject=
en-title=Drug interaction (27. anti-emetics during anti-cancer chemotherapy)
kn-title=薬物相互作用（27―がん化学療法における制吐剤の薬物相互作用）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KurataYasuko
en-aut-sei=Kurata
en-aut-mei=Yasuko
kn-aut-name=蔵田靖子
kn-aut-sei=蔵田
kn-aut-mei=靖子
aut-affil-num=1
ORCID=

en-aut-name=FujiwaraSatoko
en-aut-sei=Fujiwara
en-aut-mei=Satoko
kn-aut-name=藤原聡子
kn-aut-sei=藤原
kn-aut-mei=聡子
aut-affil-num=2
ORCID=

en-aut-name=KajizonoMakoto
en-aut-sei=Kajizono
en-aut-mei=Makoto
kn-aut-name=鍛治園誠
kn-aut-sei=鍛治園
kn-aut-mei=誠
aut-affil-num=3
ORCID=

en-aut-name=AoyagiMegumu
en-aut-sei=Aoyagi
en-aut-mei=Megumu
kn-aut-name=青柳恵
kn-aut-sei=青柳
kn-aut-mei=恵
aut-affil-num=4
ORCID=

en-aut-name=KitamuraYoshihisa
en-aut-sei=Kitamura
en-aut-mei=Yoshihisa
kn-aut-name=北村佳久
kn-aut-sei=北村
kn-aut-mei=佳久
aut-affil-num=5
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=千堂年昭
kn-aut-sei=千堂
kn-aut-mei=年昭
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学病院 薬剤部

affil-num=2
en-affil=
kn-affil=岡山大学病院 薬剤部

affil-num=3
en-affil=
kn-affil=岡山大学病院 薬剤部

affil-num=4
en-affil=
kn-affil=岡山大学病院 薬剤部

affil-num=5
en-affil=
kn-affil=岡山大学病院 薬剤部

affil-num=6
en-affil=
kn-affil=岡山大学病院 薬剤部
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=207
end-page=207
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1930
dt-pub=19300201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=甜橙の微量砒素及鉛の定量法(要旨)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野寺伊勢之助
kn-aut-sei=小野寺
kn-aut-mei=伊勢之助
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=207
end-page=207
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1930
dt-pub=19300201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=砒酸鉛の砒素定量法に就て(要旨)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野寺伊勢之助
kn-aut-sei=小野寺
kn-aut-mei=伊勢之助
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=1
article-no=
start-page=35
end-page=39
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=An epidemiologically rare case of Vibrio vulnificus infection that occurred in October in an inland city of Japan
kn-title=内陸地津山で発症した季節外れのVibrio vulnificus感染症
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　A 68-year-old man with alcohol addiction, who lived in the suburbs of Tsuyama, an inland city located in northeast Okayama prefecture, was transported to the emergency unit of the Tsuyama Central Hospital in a state of cardiopulmonary arrest (CPA). Despite rigorous systemic investigation and treatment, the patient died 2 hours after arrival. After his death, Vibrio vulnificus was isolated from his blood culture.
　Vibrio vulnificus causes fatal infection in humans, usually only in areas located close to the sea where appropriate temperature and suitable salt concentration for its growth are available. Therefore, its occurrence is epidemiologically restricted ; in Japan, the western coastal areas, especially in summers, are reported to be the high-risk regions. This is a rare case because it occurred in a city approximately 50 kilometers from both the Sea of Japan and the Pacific coast of Okayama, and at the end of October in 2011. Economic development and distribution systems have made it possible to transport various food products from coastal areas or abroad to any place in a short time, such that these infections can potentially develop in areas other than expected. We should be aware of the increasing risk of Vibrio vulnificus infection during any season and at any place, especially in patients with abnormal liver function.
en-copyright=
kn-copyright=

en-aut-name=HagiyaHideharu
en-aut-sei=Hagiya
en-aut-mei=Hideharu
kn-aut-name=萩谷英大
kn-aut-sei=萩谷
kn-aut-mei=英大
aut-affil-num=1
ORCID=

en-aut-name=ShiotaSumiko
en-aut-sei=Shiota
en-aut-mei=Sumiko
kn-aut-name=塩田澄子
kn-aut-sei=塩田
kn-aut-mei=澄子
aut-affil-num=2
ORCID=

en-aut-name=MiyoshiShin-ichi
en-aut-sei=Miyoshi
en-aut-mei=Shin-ichi
kn-aut-name=三好伸一
kn-aut-sei=三好
kn-aut-mei=伸一
aut-affil-num=3
ORCID=

en-aut-name=KuroeYasutoshi
en-aut-sei=Kuroe
en-aut-mei=Yasutoshi
kn-aut-name=黒江泰利
kn-aut-sei=黒江
kn-aut-mei=泰利
aut-affil-num=4
ORCID=

en-aut-name=NojimaHiroyoshi
en-aut-sei=Nojima
en-aut-mei=Hiroyoshi
kn-aut-name=野島宏悦
kn-aut-sei=野島
kn-aut-mei=宏悦
aut-affil-num=5
ORCID=

en-aut-name=OtaniShinkichi
en-aut-sei=Otani
en-aut-mei=Shinkichi
kn-aut-name=大谷晋吉
kn-aut-sei=大谷
kn-aut-mei=晋吉
aut-affil-num=6
ORCID=

en-aut-name=SugiyamaJunichi
en-aut-sei=Sugiyama
en-aut-mei=Junichi
kn-aut-name=杉山淳一
kn-aut-sei=杉山
kn-aut-mei=淳一
aut-affil-num=7
ORCID=

en-aut-name=NaitoHiromichi
en-aut-sei=Naito
en-aut-mei=Hiromichi
kn-aut-name=内藤宏道
kn-aut-sei=内藤
kn-aut-mei=宏道
aut-affil-num=8
ORCID=

en-aut-name=KawanishiSusumu
en-aut-sei=Kawanishi
en-aut-mei=Susumu
kn-aut-name=川西進
kn-aut-sei=川西
kn-aut-mei=進
aut-affil-num=9
ORCID=

en-aut-name=HagiokaShingo
en-aut-sei=Hagioka
en-aut-mei=Shingo
kn-aut-name=萩岡信吾
kn-aut-sei=萩岡
kn-aut-mei=信吾
aut-affil-num=10
ORCID=

en-aut-name=MorimotoNaoki
en-aut-sei=Morimoto
en-aut-mei=Naoki
kn-aut-name=森本直樹
kn-aut-sei=森本
kn-aut-mei=直樹
aut-affil-num=11
ORCID=

affil-num=1
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=2
en-affil=
kn-affil=就実大学薬学部　病原微生物学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　衛生微生物化学

affil-num=4
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=5
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=6
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=7
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=8
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=9
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=10
en-affil=
kn-affil=津山中央病院　救命救急センター

affil-num=11
en-affil=
kn-affil=津山中央病院　救命救急センター
en-keyword=Vibrio vulnificus
kn-keyword=Vibrio vulnificus
END

start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=1
article-no=
start-page=5
end-page=7
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Computational fluid dynamics of carotid arteries after carotid endarterectomy or carotid artery stenting based on postoperative patient-specific medical data
kn-title=頚動脈内膜剥離術あるいは頚動脈ステント留置術施行後の患者固有データに基づく頚動脈血流の流体力学的シミュレーション
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HayaseHitoshi
en-aut-sei=Hayase
en-aut-mei=Hitoshi
kn-aut-name=早瀬仁志
kn-aut-sei=早瀬
kn-aut-mei=仁志
aut-affil-num=1
ORCID=

en-aut-name=TokunagaKoji
en-aut-sei=Tokunaga
en-aut-mei=Koji
kn-aut-name=徳永浩司
kn-aut-sei=徳永
kn-aut-mei=浩司
aut-affil-num=2
ORCID=

en-aut-name=NakayamaToshio
en-aut-sei=Nakayama
en-aut-mei=Toshio
kn-aut-name=中山敏男
kn-aut-sei=中山
kn-aut-mei=敏男
aut-affil-num=3
ORCID=

en-aut-name=SugiuKenji
en-aut-sei=Sugiu
en-aut-mei=Kenji
kn-aut-name=杉生憲志
kn-aut-sei=杉生
kn-aut-mei=憲志
aut-affil-num=4
ORCID=

en-aut-name=NishidaAyumi
en-aut-sei=Nishida
en-aut-mei=Ayumi
kn-aut-name=西田あゆみ
kn-aut-sei=西田
kn-aut-mei=あゆみ
aut-affil-num=5
ORCID=

en-aut-name=ArimitsuSeiji
en-aut-sei=Arimitsu
en-aut-mei=Seiji
kn-aut-name=有光帥二
kn-aut-sei=有光
kn-aut-mei=帥二
aut-affil-num=6
ORCID=

en-aut-name=HishikawaTomohito
en-aut-sei=Hishikawa
en-aut-mei=Tomohito
kn-aut-name=菱川朋人
kn-aut-sei=菱川
kn-aut-mei=朋人
aut-affil-num=7
ORCID=

en-aut-name=OnoShigeki
en-aut-sei=Ono
en-aut-mei=Shigeki
kn-aut-name=小野成紀
kn-aut-sei=小野
kn-aut-mei=成紀
aut-affil-num=8
ORCID=

en-aut-name=OhtaMakoto
en-aut-sei=Ohta
en-aut-mei=Makoto
kn-aut-name=太田信
kn-aut-sei=太田
kn-aut-mei=信
aut-affil-num=9
ORCID=

en-aut-name=DateIsao
en-aut-sei=Date
en-aut-mei=Isao
kn-aut-name=伊達勲
kn-aut-sei=伊達
kn-aut-mei=勲
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学

affil-num=3
en-affil=
kn-affil=東北大学流体科学研究所　知能流システム研究部門生体流動研究分野

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学

affil-num=9
en-affil=
kn-affil=東北大学流体科学研究所　知能流システム研究部門生体流動研究分野

affil-num=10
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学
en-keyword=carotid artery stenosis
kn-keyword=carotid artery stenosis
en-keyword=carotid artery stenting
kn-keyword=carotid artery stenting
en-keyword=carotid endarterectomy
kn-keyword=carotid endarterectomy
en-keyword=computational fluid dynamics
kn-keyword=computational fluid dynamics
en-keyword=wall shear stress
kn-keyword=wall shear stress
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=
article-no=
start-page=58
end-page=67
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1929
dt-pub=19290705
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=甜橙の微量砒素及鉛の定量法
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野寺伊勢之助
kn-aut-sei=小野寺
kn-aut-mei=伊勢之助
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=
article-no=
start-page=45
end-page=57
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1929
dt-pub=19290705
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=砒酸鉛の砒素定量法に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野寺伊勢之助
kn-aut-sei=小野寺
kn-aut-mei=伊勢之助
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=
article-no=
start-page=78
end-page=110
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1920
dt-pub=19200710
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=紫雲英の稻作に及ぼす影響及其有害作用の原因に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野寺伊勢之助
kn-aut-sei=小野寺
kn-aut-mei=伊勢之助
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=3
article-no=
start-page=239
end-page=241
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20121203
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of frontal horn cysts
kn-title=Frontal Horn Cystsの１例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　We herein report a case of bilateral frontal horn cysts. The infant was delivered with a low birth weight (1,710g) at 31 weeks, 0 days by emergency Cesarean section. She was severely asphyxiated and exhibited respiratory distress syndrome. Surfactant was administered, and mechanical ventilation was required until 21 days of age. Brain computed tomography (CT) at 45 days of age revealed bilateral cysts adjacent to the frontal horns of the lateral ventricles. Her growth and development were normal. At 1 and a half- years of age, she underwent brain CT again and the above-mentioned cystic abnormality had disappeared. No dilatation or irregularity of the lateral ventricles was found. Normal development and transient abnormal cystic findings in brain CT suggested a diagnosis of frontal horn cysts. Frontal horn cysts should be considered as the causes of cystic lesions of the brain.
en-copyright=
kn-copyright=

en-aut-name=MiyakeSusumu
en-aut-sei=Miyake
en-aut-mei=Susumu
kn-aut-name=三宅進
kn-aut-sei=三宅
kn-aut-mei=進
aut-affil-num=1
ORCID=

en-aut-name=MiyamuraTakako
en-aut-sei=Miyamura
en-aut-mei=Takako
kn-aut-name=宮村能子
kn-aut-sei=宮村
kn-aut-mei=能子
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=香川県立中央病院　小児科

affil-num=2
en-affil=
kn-affil=香川県立中央病院　小児科
en-keyword=frontal horn cyst
kn-keyword=frontal horn cyst
en-keyword=頭部CT（Brain CT）
kn-keyword=頭部CT（Brain CT）
en-keyword=新生児（neonate）
kn-keyword=新生児（neonate）
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=2
article-no=
start-page=167
end-page=173
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Drug interaction (24. drug-drug interactions in intensive care unit)
kn-title=薬物相互作用(24―ICUでの注意すべき薬物相互作用）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NishimiyaYusuke
en-aut-sei=Nishimiya
en-aut-mei=Yusuke
kn-aut-name=西宮祐輔
kn-aut-sei=西宮
kn-aut-mei=祐輔
aut-affil-num=1
ORCID=

en-aut-name=KonumaToshimitsu
en-aut-sei=Konuma
en-aut-mei=Toshimitsu
kn-aut-name=小沼利光
kn-aut-sei=小沼
kn-aut-mei=利光
aut-affil-num=2
ORCID=

en-aut-name=TasakaKen
en-aut-sei=Tasaka
en-aut-mei=Ken
kn-aut-name=田坂健
kn-aut-sei=田坂
kn-aut-mei=健
aut-affil-num=3
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=千堂年昭
kn-aut-sei=千堂
kn-aut-mei=年昭
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学病院　薬剤部

affil-num=2
en-affil=
kn-affil=岡山大学病院　薬剤部

affil-num=3
en-affil=
kn-affil=岡山大学病院　薬剤部

affil-num=4
en-affil=
kn-affil=岡山大学病院　薬剤部
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=2
article-no=
start-page=149
end-page=153
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of strangulated ileus caused by transomental hernia with reference to previously reported cases
kn-title=術前診断し得た大網裂孔ヘルニアの一例―本邦報告203例の臨床病理学的検討―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Transomental hernia often develops into strangulated ileus. We report on an 81-year-old man with strangulated ileus due to transomental hernia, diagnosed preoperatively by abdominal CT. The patient was referred to our surgical division because of progressive abdominal pain and vomiting. He had no history of laparotomy. An abdominal CT scan showed dilated small intestinal loops with intraluminal air and strangulated small intestinal loops with engorged mesenteric vessels. We diagnosed this as a strangulated internal hernia due to transomental hernia and conducted an emergency laparotomy. The jejunum had herniated through an abnormal hiatus of the greater omentum to the peritoneal cavity. The strangulated intestinal loop, about 15 cm long, was released and the postoperative course was uneventful. In the absence of a previous laparotomy, the differential diagnosis of intestinal obstruction should include internal hernia. An abdominal CT scan is useful for the preoperative and prompt diagnosis of transomental hernia.
en-copyright=
kn-copyright=

en-aut-name=KimuraYuji
en-aut-sei=Kimura
en-aut-mei=Yuji
kn-aut-name=木村裕司
kn-aut-sei=木村
kn-aut-mei=裕司
aut-affil-num=1
ORCID=

en-aut-name=IwakawaKazuhide
en-aut-sei=Iwakawa
en-aut-mei=Kazuhide
kn-aut-name=岩川和秀
kn-aut-sei=岩川
kn-aut-mei=和秀
aut-affil-num=2
ORCID=

en-aut-name=NishieManabu
en-aut-sei=Nishie
en-aut-mei=Manabu
kn-aut-name=西江学
kn-aut-sei=西江
kn-aut-mei=学
aut-affil-num=3
ORCID=

en-aut-name=InagakiMasaru
en-aut-sei=Inagaki
en-aut-mei=Masaru
kn-aut-name=稲垣優
kn-aut-sei=稲垣
kn-aut-mei=優
aut-affil-num=4
ORCID=

en-aut-name=IwagakiHiromi
en-aut-sei=Iwagaki
en-aut-mei=Hiromi
kn-aut-name=岩垣博巳
kn-aut-sei=岩垣
kn-aut-mei=博巳
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=2
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=3
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=4
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=5
en-affil=
kn-affil=国立病院機構福山医療センター　外科
en-keyword=大網裂孔ヘルニア（transomental hernia）
kn-keyword=大網裂孔ヘルニア（transomental hernia）
en-keyword=絞扼性イレウス（strangulated ileus）
kn-keyword=絞扼性イレウス（strangulated ileus）
END

start-ver=1.4
cd-journal=joma
no-vol=28
cd-vols=
no-issue=
article-no=
start-page=36
end-page=39
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201204
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Inactivation Effect of Weak Acid Hypochlorous Solution against Cryj1,Cedar Pollen Allergen
kn-title=弱酸性次亜塩素酸水溶液のスギ花粉アレルゲンCryj1に対する不活化効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnoTomoko
en-aut-sei=Ono
en-aut-mei=Tomoko
kn-aut-name=小野朋子
kn-aut-sei=小野
kn-aut-mei=朋子
aut-affil-num=1
ORCID=

en-aut-name=YamashitaKoji
en-aut-sei=Yamashita
en-aut-mei=Koji
kn-aut-name=山下光治
kn-aut-sei=山下
kn-aut-mei=光治
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=株式会社エイチ・エス・ピー

affil-num=2
en-affil=
kn-affil=株式会社エイチ・エス・ピー
END

start-ver=1.4
cd-journal=joma
no-vol=86
cd-vols=
no-issue=9
article-no=
start-page=1440
end-page=1449
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1995
dt-pub=199509
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=緑膿菌バイオフｨルム解析法としてのglycocalyx簡易定量法とATP測定法
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=(背景と目的) 細菌バイオフィルムの各エレメントの解析法として, トルイジンブルーを用いるglycocalyxの簡易定量法, ならびに, bioactivity測定法としてのATP測定法を新たに考案ないし改良して, その有用性に検討を加えた. (結果) 基礎的検討において, 既知量のglycocalyxとしてgellan gumを用いた場合, トルイジンブルー反応量を示す吸光度はgellan gum量4.0×10^<-6>〜1.0×10^<-4>gの範囲で直線性を示した.また, 改良を加えたATP測定法では, ATP量で1×l0^<-4>mol/l, 浮遊菌数で10^3cfuまでの測定が可能であった.また, modified Robbins deviceを使用するin vitro実験系において, 緑膿菌バイオフィルムの経時的形成過程ならびに各種抗菌性物質作用後の変化の解析において, 両測定法によるglycocalyx量とbioactivityに関する成績は, 論理的に矛盾がなく走査型電子顕微鏡所見とも極めてよく一致していた. (結論) したがって, 両測定法は細菌バイオフィルムの新しい解析法として有用であると考えられた.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野憲昭
kn-aut-sei=小野
kn-aut-mei=憲昭
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=1
article-no=
start-page=63
end-page=66
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Pathological complete response of advanced gastric cancer with pyloric stenosis to neoadjuvant S-1/CDDP chemotherapy: A case report
kn-title=S-1/CDDP術前化学療法により組織学的CRが得られた幽門狭窄合併進行胃癌の１例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 59-year-old man with epigastric discomfort and anorexia was referred to our hospital. Endoscopy revealed a type 3 advanced gastric cancer with pyloric stenosis diagnosed as a poorly differentiated adenocarcinoma in the biopsy specimens. A gastrojejunal bypass operation was performed because of direct invasion to the pancreas. The patient was treated by three courses of neoadjuvant chemotherapy with S-1/CDDP. Follow-up abdominal CT scan revealed that the primary tumor had become smaller, suggesting that a partial response had been achieved. Distal gastrectomy with D2 lymphadenectomy was performed. The histopathological examination showed no residual cancer cells in the primary lesion or dissected lymph nodes. Final chemotherapy efficacy was evaluated as Grade 3. The patient was treated with S-1 for one year after the gastrectomy and lymphadenectomy and has been followed up for 18 months without evidence of recurrence.
en-copyright=
kn-copyright=

en-aut-name=NishizakiMasahiko
en-aut-sei=Nishizaki
en-aut-mei=Masahiko
kn-aut-name=西崎正彦
kn-aut-sei=西崎
kn-aut-mei=正彦
aut-affil-num=1
ORCID=

en-aut-name=FujiwaraYasuhiro
en-aut-sei=Fujiwara
en-aut-mei=Yasuhiro
kn-aut-name=藤原康宏
kn-aut-sei=藤原
kn-aut-mei=康宏
aut-affil-num=2
ORCID=

en-aut-name=ChoudaYasuhiro
en-aut-sei=Chouda
en-aut-mei=Yasuhiro
kn-aut-name=丁田泰宏
kn-aut-sei=丁田
kn-aut-mei=泰宏
aut-affil-num=3
ORCID=

en-aut-name=KanazawaTakashi
en-aut-sei=Kanazawa
en-aut-mei=Takashi
kn-aut-name=金澤卓
kn-aut-sei=金澤
kn-aut-mei=卓
aut-affil-num=4
ORCID=

en-aut-name=NinomiyaMotoki
en-aut-sei=Ninomiya
en-aut-mei=Motoki
kn-aut-name=二宮基樹
kn-aut-sei=二宮
kn-aut-mei=基樹
aut-affil-num=5
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=2
en-affil=
kn-affil=広島市立広島市民病院　外科

affil-num=3
en-affil=
kn-affil=広島市立広島市民病院　外科

affil-num=4
en-affil=
kn-affil=広島市立広島市民病院　外科

affil-num=5
en-affil=
kn-affil=広島市立広島市民病院　外科

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学
en-keyword=幽門狭窄 (pyloric stenosis)
kn-keyword=幽門狭窄 (pyloric stenosis)
en-keyword=進行胃癌 (advanced gastric cancer)
kn-keyword=進行胃癌 (advanced gastric cancer)
en-keyword=S-1/CDDP
kn-keyword=S-1/CDDP
en-keyword=術前化学療法 (neoadjuvant chemotherapy)
kn-keyword=術前化学療法 (neoadjuvant chemotherapy)
en-keyword=組織学的CR (pathological CR)
kn-keyword=組織学的CR (pathological CR)
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=1
article-no=
start-page=53
end-page=57
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Two cases of lymphoepithelial cyst of the pancreas
kn-title=膵リンパ上皮嚢胞の2例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 35-year-old man was found to have a cystic mass in the pancreatic body on a routine health examination ; high serum CA19-9 was also detected. The enucleated cyst was diagnosed as a lymphoepithelial cyst (LEC). A 74-year-old man found to have a cystic mass in the pancreatic head by computer tomography as well as high serum CA19-9 was suspected of a cystic neoplasm of the pancreas (IPMN), and pylorus-preserving pancreaticoduodenectomy (PPPD) was performed. Pathologically, the cyst was found to be LEC. It is often difficult to diagnose pancreatic cyst as LEC preoperatively. Care should be taken not to do over-surgery for benign disease LEC.
en-copyright=
kn-copyright=

en-aut-name=HamanoRyosuke
en-aut-sei=Hamano
en-aut-mei=Ryosuke
kn-aut-name=濱野亮輔
kn-aut-sei=濱野
kn-aut-mei=亮輔
aut-affil-num=1
ORCID=

en-aut-name=InagakiMasaru
en-aut-sei=Inagaki
en-aut-mei=Masaru
kn-aut-name=稲垣優
kn-aut-sei=稲垣
kn-aut-mei=優
aut-affil-num=2
ORCID=

en-aut-name=KimuraYuuji
en-aut-sei=Kimura
en-aut-mei=Yuuji
kn-aut-name=木村祐司
kn-aut-sei=木村
kn-aut-mei=祐司
aut-affil-num=3
ORCID=

en-aut-name=IsodaKenta
en-aut-sei=Isoda
en-aut-mei=Kenta
kn-aut-name=磯田健太
kn-aut-sei=磯田
kn-aut-mei=健太
aut-affil-num=4
ORCID=

en-aut-name=KitadaKoji
en-aut-sei=Kitada
en-aut-mei=Koji
kn-aut-name=北田浩二
kn-aut-sei=北田
kn-aut-mei=浩二
aut-affil-num=5
ORCID=

en-aut-name=NishieManabu
en-aut-sei=Nishie
en-aut-mei=Manabu
kn-aut-name=西江学
kn-aut-sei=西江
kn-aut-mei=学
aut-affil-num=6
ORCID=

en-aut-name=NomuraNagahisa
en-aut-sei=Nomura
en-aut-mei=Nagahisa
kn-aut-name=野村長久
kn-aut-sei=野村
kn-aut-mei=長久
aut-affil-num=7
ORCID=

en-aut-name=TokunagaNaoyuki
en-aut-sei=Tokunaga
en-aut-mei=Naoyuki
kn-aut-name=徳永尚之
kn-aut-sei=徳永
kn-aut-mei=尚之
aut-affil-num=8
ORCID=

en-aut-name=TakahashiKenji
en-aut-sei=Takahashi
en-aut-mei=Kenji
kn-aut-name=高橋健司
kn-aut-sei=高橋
kn-aut-mei=健司
aut-affil-num=9
ORCID=

en-aut-name=MiyasouHideaki
en-aut-sei=Miyasou
en-aut-mei=Hideaki
kn-aut-name=宮宗秀明
kn-aut-sei=宮宗
kn-aut-mei=秀明
aut-affil-num=10
ORCID=

en-aut-name=TsunemitsuYosuke
en-aut-sei=Tsunemitsu
en-aut-mei=Yosuke
kn-aut-name=常光洋輔
kn-aut-sei=常光
kn-aut-mei=洋輔
aut-affil-num=11
ORCID=

en-aut-name=OhtsukaShinya
en-aut-sei=Ohtsuka
en-aut-mei=Shinya
kn-aut-name=大塚眞哉
kn-aut-sei=大塚
kn-aut-mei=眞哉
aut-affil-num=12
ORCID=

en-aut-name=MiyoshiKazuya
en-aut-sei=Miyoshi
en-aut-mei=Kazuya
kn-aut-name=三好和也
kn-aut-sei=三好
kn-aut-mei=和也
aut-affil-num=13
ORCID=

en-aut-name=IwakawaKazuhide
en-aut-sei=Iwakawa
en-aut-mei=Kazuhide
kn-aut-name=岩川和秀
kn-aut-sei=岩川
kn-aut-mei=和秀
aut-affil-num=14
ORCID=

en-aut-name=TakahashiMasahiko
en-aut-sei=Takahashi
en-aut-mei=Masahiko
kn-aut-name=高橋正彦
kn-aut-sei=高橋
kn-aut-mei=正彦
aut-affil-num=15
ORCID=

en-aut-name=IwagakiHiromi
en-aut-sei=Iwagaki
en-aut-mei=Hiromi
kn-aut-name=岩垣博巳
kn-aut-sei=岩垣
kn-aut-mei=博巳
aut-affil-num=16
ORCID=

affil-num=1
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=2
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=3
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=4
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=5
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=6
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=7
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=8
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=9
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=10
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=11
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=12
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=13
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=14
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=15
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=16
en-affil=
kn-affil=国立病院機構福山医療センター　外科
en-keyword=リンパ上皮嚢胞 (lymphoepithelial cyst)
kn-keyword=リンパ上皮嚢胞 (lymphoepithelial cyst)
END

start-ver=1.4
cd-journal=joma
no-vol=31
cd-vols=
no-issue=350
article-no=
start-page=281
end-page=290
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1919
dt-pub=19190331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=「アルカロイド」ノ毒力ト其膠質状態トノ關係
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野寺直助
kn-aut-sei=小野寺
kn-aut-mei=直助
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=九州帝國醫科大學
END

start-ver=1.4
cd-journal=joma
no-vol=301
cd-vols=
no-issue=1
article-no=
start-page=57
end-page=62
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Serological analysis of a recombinant cDNA expression library (SEREX) derived from two lung adenocarcinoma cancer cell lines using autologous sera led to the isolation of 41 positive cDNA clones comprising 28 different antigens. They coded for a variety of nuclear and cytoplasmic proteins. Among the antigens, nucleoporin 107 (NUP107) was isolated most frequently (5 of 41 clones). The second most frequently isolated antigen was coded for by C21orf58 (4 of 41 clones). During serological analysis of selected antigens based on their reactivity to sera from normal individuals and lung cancer patients, none of the antigens showed a cancer-restricted recognition pattern. However, five genes including NUP107 showed higher expression when we examined the changes in gene expression in five different adenocarcinoma cell lines, including those used in SEREX, compared with their levels in normal lung tissues by cDNA microarray analysis. On the other hand, the expression levels of five genes including C21orf58 were down regulated in all adenocarcinoma cell lines. This SEREX study combining comprehensive gene expression assays has added to the growing list of lung cancer antigens, which may aid the development of diagnostic and immunotherapeutic reagents for patients with lung cancer.
en-copyright=
kn-copyright=

en-aut-name=HanafusaTadashi
en-aut-sei=Hanafusa
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MohamedAli Eldib Ali
en-aut-sei=Mohamed
en-aut-mei=Ali Eldib Ali
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KitaokaKenta
en-aut-sei=Kitaoka
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OhueYoshihiro
en-aut-sei=Ohue
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakayamaEiichi
en-aut-sei=Nakayama
en-aut-mei=Eiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Radiation Research, Advanced Science Research Center, Okayama University

affil-num=2
en-affil=
kn-affil=Faculty of Science, Alexandria University

affil-num=3
en-affil=
kn-affil=Hyogo Prefectural Awaji Hospital

affil-num=4
en-affil=
kn-affil=Department of Medicine, Kawasaki Medical University

affil-num=5
en-affil=
kn-affil=Faculty of Health and Welfare, Kawasaki University of Medical Welfare

affil-num=6
en-affil=
kn-affil=Department of Radiation Research, Advanced Science Research Center, Okayama University
en-keyword=Lung adenocarcinoma
kn-keyword=Lung adenocarcinoma
en-keyword=SEREX
kn-keyword=SEREX
en-keyword=Tumor antigen
kn-keyword=Tumor antigen
en-keyword=NUP107
kn-keyword=NUP107
en-keyword=MYL6B
kn-keyword=MYL6B
END

start-ver=1.4
cd-journal=joma
no-vol=123
cd-vols=
no-issue=2
article-no=
start-page=129
end-page=132
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Laparoscopic surgery for mesenteric Castleman's disease
kn-title=腹腔鏡下に摘出しえた上行結腸間膜発生のCastleman病の１例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We report herein a case of mesenteric Castleman's disease which was confirmed on pathology. A 60-year-old man was admitted to our hospital complaining of abdominal pain. On the physical examination, there was no palpable mass. Computed tomography findings and magnetic resonance imaging revealed a well circumscribed, lobulated round mass on the right side of the superior mesenteric vein. Laparoscopic surgery for the mesenteric tumor was carried out to obtain a definite diagnosis and treatment. In the operative field, the mass was located on the ascending colic mesentery and measured about 3 cm in size. It was solid and surrounded by a thin fibrous capsule. The histological diagnosis of the mesenteric tumor was hyaline vascular type Castleman's disease. The postoperative course of the patient was uneventful, and he was discharged on the 10th postoperative day.
en-copyright=
kn-copyright=

en-aut-name=NishieManabu
en-aut-sei=Nishie
en-aut-mei=Manabu
kn-aut-name=西江学
kn-aut-sei=西江
kn-aut-mei=学
aut-affil-num=1
ORCID=

en-aut-name=OtsukaShinya
en-aut-sei=Otsuka
en-aut-mei=Shinya
kn-aut-name=大塚真哉
kn-aut-sei=大塚
kn-aut-mei=真哉
aut-affil-num=2
ORCID=

en-aut-name=TomodaJun
en-aut-sei=Tomoda
en-aut-mei=Jun
kn-aut-name=友田純
kn-aut-sei=友田
kn-aut-mei=純
aut-affil-num=3
ORCID=

en-aut-name=FujiwaraKeishi
en-aut-sei=Fujiwara
en-aut-mei=Keishi
kn-aut-name=藤原敬士
kn-aut-sei=藤原
kn-aut-mei=敬士
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=2
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=3
en-affil=
kn-affil=国立病院機構福山医療センター　内科

affil-num=4
en-affil=
kn-affil=光生病院　内科
en-keyword=結腸間膜 (mesocolon)
kn-keyword=結腸間膜 (mesocolon)
en-keyword=Castleman病 (Castleman's disease)
kn-keyword=Castleman病 (Castleman's disease)
en-keyword=腹腔鏡手術 (laparoscopic surgery)
kn-keyword=腹腔鏡手術 (laparoscopic surgery)
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=食に関する教育と新しいスタイルの学校給食-個を尊重する学校教育の視点から-
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnoHisami
en-aut-sei=Ono
en-aut-mei=Hisami
kn-aut-name=小野尚美
kn-aut-sei=小野
kn-aut-mei=尚美
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=46
cd-vols=
no-issue=8
article-no=
start-page=1899
end-page=1922
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1934
dt-pub=19340831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Über die Studien von Spaltung und Ansscheidung des Fettes in der Leber; besonders über den Einfluss der Milz auf diese Mechanismus
kn-title=肝臟ノ脂肪分解及ビ排泄機轉ノ研究竝ニ該機轉ニ及ボス脾臟ノ影響ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Der Verfasser studierte experimentelle über das Schicksal der Fett, die hämatogen in die Leber transportiert wurde; und forschte besonders über den Einfluss der Milz darüber. Die Versuchsordnung ist folgende: 1) Zuerst bestätigte quantitativ die Fettsaure im Pfortaderblute, Lebervenenblute, und in der Blasengalle beim normalen Hündchen; gleichzeitig excisierte ein Teil von Leber zur histologischen Untersuchung über die Fettablagerung in der Leber. 2) Bei einer Gruppe von H-ündchen, die ide "Olivenölemulsion" P.K. 10cc. intravenöe injciert wurden, forschte innen 5 Minuten bis 24 Stunden nach der Injektion oben erwähnte Einzellheiten. 3) Bei anderer Gruppe von Hündchen, die splenektomiert wurden, forschte nach 1 Woche oben erwäahnte Einzellheiten. 4) Zuletzt studierte bei splenektomierten Hündchen, die die "Olivenölemulsion" P.K. 10cc. intravenos injciert wurden, oben erwähte Einzellheiten. Die Resultate lauteten: 1) Das Fettwird in der Leber immer zuerst von Sternzellen phagozytiert und dann geht in die Leberzellen über und hier wird es enthalten. 2) Das Fett, das einmal in der Leberzellen enthalten wird, teils gespaltet und ein Teil davon wird zum Lipoid verändert, teils durch Sternzellen wieder in das Blut oder in die Lymphe ausscheiden wird. Ein weniger übniger Teil von Fett wird direkt von Leberzellen als Gallenbestandteil in die Gallenwag ausscheiden. 3) Solche Funktionen von Leberzellen wie Enthaltung oder Spaltung von Fett und Lipoidbildung oder Ausscheidung desselben kommen durch Milzexstirpation deutlich herunter, demgemass vermindert sich stark die Wirkung der Leber zur Enthaltung von Fett.
en-copyright=
kn-copyright=

en-aut-name=OnoTetsuji
en-aut-sei=Ono
en-aut-mei=Tetsuji
kn-aut-name=小野哲二
kn-aut-sei=小野
kn-aut-mei=哲二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學石山外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=46
cd-vols=
no-issue=8
article-no=
start-page=1749
end-page=1773
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1934
dt-pub=19340831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Über die klinische Bedeutung der Milz auf Fettstoffwechsel der Leber. (II. Mitteilung.)
kn-title=肝臟脂肪新陳代謝機能ニ對スル脾臟ノ意義ニ就テ（第2報）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Als weitere Untersuchungsmethode über die Bedeutung der Milz gegen die Leber, besonders auf Fettstoffwechsel benutzte der Verfasser selbat neu-geschaffte "Olivenölemulsion", die zur Forschung von Fettstoffwechsel ein ideales Mittel ist. Die Versuchstiere teilte der Verfasser folgende 7. Untergruppe ein. 1. Gruppe: Normale Hündchen. 2. Gruppe: Splenektomierte Hündchen. 3-4. Gruppe: Normale und splenektomierte Hündchen, die alle ihre R.E.S. mit Collargollösung brockiert wurden. 5-6. Gruppe: Normale und splenektomierte Hündchen, die alle ihre Leberzellen mit CCl(4) geschädigt wurden. 7. Gruppe: Splenektomierte Hündchen, die alle die Injektion von Milzextrakt
bekaminen. Der Verfasser benutzte diese 7. Gruppe von Hündchen zur Forschung von Fettstoffwechsel
der Leber und dekam folgende Resultate. Die Milzexstirpation gibt keinen Einfluss auf die Funktionsveränderung der Sternzellen über Fettstoffwechsel, sondern mehr Einfluss auf Leberzellen, Die Ursache von dieser Wechselbeziehung zueisehen Milz und Leberzellen sei behufs dem Einfluss von Milzhormon. Der Verfasser studierte weiter die histologische Veränderung von Golgische Apparat von Leberzellen beim normalen und splenektomierten Hündchen und bestätigte deutliche Degeneration beim letzten Tiere.
en-copyright=
kn-copyright=

en-aut-name=OnoTetsuji
en-aut-sei=Ono
en-aut-mei=Tetsuji
kn-aut-name=小野哲二
kn-aut-sei=小野
kn-aut-mei=哲二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學石山外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=46
cd-vols=
no-issue=7
article-no=
start-page=1627
end-page=1655
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1934
dt-pub=19340731
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Über die klinische Bedeutung der Milz auf Fettstoffwechsel der Leber. (I. Mitteilung.)
kn-title=肝臓脂肪新陳代謝機能ニ對スル脾臓ノ意義ニ就テ（第1報）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Der Verfasser studierte experimentelle über die klinische Bedeutung der Milzgegen die Leber in bezug auf Fettstoffwechsel. Als Versuchtier benutzte das Hund und forschte hauptsächlich histologische Veränderung mitsamt biochemische Untersuchung der Leber. Die Ordnung der Untersuchung lautet; 1) Bezüglich der quantitativen Verändernng von Fettablagerung der Leber und Fettgehalt im Blute forschte der Verfasser beim normalen Hunde genau chemisch und noch dazu histologisch. 2) Bei einer Gruppe von Hündchen, die splenektomiert wurden, untersuchte der Verfasser hauptsächlich die Leberveräanderund und der Fettgehalt im Blute. 3) Diese Forschung setzte der Verfasser weiter nach Brockierung von R.E.S. mit 1% Collargollosung beim normale und splenektomierten Hündchen fort. 4) Dann forschte der Verfasser obengenaunte Veränderung der Leber und des Blutes nach Injektion von 1% Collargollösung im Reizdose gegen R.E.S, 5) Nach Schädigung von Funktion der Leberzellen mit CCl4 beim normalen und splenektomierten Hündchen beobachtete der Verfasser 5 W, lang die Veränderung von Leber und Fettgehalt im Blute. 6) Zuletzt injcierte deu Reizdosis von CCl4 zu solchen Händchen und forschte genau oben genaunte Einzellheiten. Schlässsatze; 1) Jede Sternzellen und Leberzellen haben besondere klinische Bedeutung auf Fettstoffwechsel der Leber und zwar stehen Jeder für sich in unterennbarer Beziehung. 2) Es schcint die Abnahme von Fettstoffwechsel der Leber durch Splenektomie hervortreten und infolgedessen wird die Veräuderung von Fettstoffwechsel der Leber herbeiführen. 3) Die Hyperlipämie nach Milzexstirpation soll seine Ursache nicht nur auf die Funktionsstörung von R.E.S. sondern auch auf solche von Leberzellen zurückzuführen.
en-copyright=
kn-copyright=

en-aut-name=OnoTetsuji
en-aut-sei=Ono
en-aut-mei=Tetsuji
kn-aut-name=小野哲二
kn-aut-sei=小野
kn-aut-mei=哲二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學石山外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=65
cd-vols=
no-issue=2
article-no=
start-page=91
end-page=95
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=201104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An Assessment of Radioactivity Levels of 210Pb and 40K in Tobacco and Radiation Exposure from Smoking
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=No research has been conducted on the radiation influence of tobacco on the alimentary system, although there have been some previous works on the respiratory system. In this study, the radioactive concentrations of 210Pb and 40K in a cigarette sample were first measured. The transfer factors of the nuclides from tobacco into smoke and solution (saliva and/or alcohol) were then examined. Moreover, the radiation doses from smoke inhalation were also evaluated. The radioactive concentrations of 210Pb and 40K in the cigarette tobacco were 0.01 and 0.3 Bq/cigarette. Since this 210Pb activity and the 210Po activity previously reported for the same sample were comparable, it can be concluded that there was a radioactive equilibrium between the 2 nuclides. The observed transfer factor of 210Pb (12%) into smoke was almost the same as that of 40K (15%), whereas the reported value for 210Po (60%) was significantly higher. The radiation doses due to inhalation of cigarette smoke varied from organ to organ, depending on the organotropic properties of the nuclide. For example, the kidneys, respiratory tract, and spleen showed relatively high doses from 210Pb and 210Po. The leaching rates indicated an inconsistent tendency related to solution types. This result could suggest that alcohol drinking, which is common in smokers, does not especially enhance the leaching characteristics.
en-copyright=
kn-copyright=

en-aut-name=NagamatsuTomohiro
en-aut-sei=Nagamatsu
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University

affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University

affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University

affil-num=4
en-affil=
kn-affil=Department of Radiation Research Shikata Laboratory, Advanced Science Research Center, Okayama University

affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=tobacco
kn-keyword=tobacco
en-keyword=radionuclides
kn-keyword=radionuclides
en-keyword=smoking
kn-keyword=smoking
en-keyword=intake
kn-keyword=intake
en-keyword=radiation exposure
kn-keyword=radiation exposure
END

start-ver=1.4
cd-journal=joma
no-vol=51
cd-vols=
no-issue=6
article-no=
start-page=1292
end-page=1307
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1939
dt-pub=19390630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Serologische Studien über den Hunger. (I. Mitteilung) Über den Einfluss des Hungers auf die Antikörperbildung, Komplementwert und Blutgerinnungszeit.
kn-title=饑餓ノ免疫學的研究（第1報）饑餓ノ免疫體産生ニ及ボス影響（附: 血清補體價竝ニ血液凝固作用ニ及ボス影響）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Der Einfluss des Hungers auf die Antikörperbildung wurde schon von vielen Forschern untersucht, die zu ganz verschiedenen Ergebuissen gelangten. Die einen meinten, dass die Antikörperbilduug bei langdauernder Hungerzeit gehiudert wurde; andere dagegen behaupteten, dass die Antikörperbildung bei Hungerzeit keinen nennensAntikörperbildung viel besser als beim Normalzustand des Versuchtiers beobachtet werden könne. Daher untersuchte ich bei Kaninchen und Meerschweinchen den Einfluss des Hungers auf verschiedene Antikörperarten, besonders unter Anwendung der Ogata'schen Immunkörperverdünnungsmethode bei Präzipitinbestimmung, und bei normalen Tieren den Komplementgehalt und die Blutgerinnungszeit. Die Ergebnisse lassen sich folgendermassen kurz zusammenfassen: 1) Die Präzipitinbildung gegen Ziegenserun bei Versuchstieren lässt beim absoluten Hungerversuch keinen grossen Unterschied gegenüber Kontrolltieren erkennen, bgleich vor dem Tod des Tieres eine etwas raschere Verminderung des Präzipitins als beim Kontrolltier stattfindet. 2) Haemoagglutininbildung gegen Hühnerblutkorperchen wird bei absoluter Hungerzeit etwas vermindert und ist dabei die Dauer des Maximums des Haemoagglutunins beim Versuchtier gegenüber dem Kontrolltier verkürzt. 3) Die Agglutininbildung von Bact. coli bei absolutem Hunger ist ebenso wie beim Haemoagglutinin schwächer als beim Kontrolltiere. 4) Der Einfluss des absoluten Hungers auf den Komplementgehalt ist verschieden, bei den einen wird er vermindert, bei anderen wird keine Verminderung des Komplementgehaltes beobachtet. 5) Im frühen Stadium des Hungerversuchs ist die Blutgerinnungszeit von Kaninchen und Meerschweinchen etwas beschleunigt, beim Spätstadium dagegen verlangsamt.
en-copyright=
kn-copyright=

en-aut-name=OnoHideo
en-aut-sei=Ono
en-aut-mei=Hideo
kn-aut-name=小野英夫
kn-aut-sei=小野
kn-aut-mei=英夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學衛生學教室
END

start-ver=1.4
cd-journal=joma
no-vol=123
cd-vols=
no-issue=1
article-no=
start-page=33
end-page=38
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Investigation of laparoscopic therapy in 56 cases of duodenal ulcer perforation
kn-title=十二指腸潰瘍穿孔に対する治療法の適応についての検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Although conservative therapy has been acceptable as the first-line therapy for duodenal ulcer (DU) perforations, surgical therapies are known to have certain advantages. We investigated the indications for laparoscopic (LS) or open surgery (OS) or conservative therapy (CoT) among 56 DU perforation cases over 5 years. Methods: 31 LSs, 22 OSs and 5 CoTs were analyzed for patient's physical and surgical factors and clinical course. Results: Mean age was 51.6. Male/female ratio was 49/9. Survival ratio was 98%. Although the hospital stay (10.9 vs 19.5 days) and analgesic administrations (1.9 vs 4.6 days) were significantly shorter in LS than OS, almost all OS patients were in serious condition as evidenced by longer waiting time before treatment, stronger pain, bigger hole of perforation, more ascites accumulation and higher morbidity of complications. Two cases of multisurgery were experienced in both LS and OS groups due to leakage of seam, abscess formation, relapsed ulcer or idiopathic intestinal perforation. LS is a therapy more widely usable and more beneficial than the other two. Conclusion: LS, a minimally invasive surgery for DU perforation, should be considered as a first-line standard therapy because of significant advantages such as shorter hospital stay. OS or CoT may be selected when appropriate.
en-copyright=
kn-copyright=

en-aut-name=IshidoNobuhiro
en-aut-sei=Ishido
en-aut-mei=Nobuhiro
kn-aut-name=石堂展宏
kn-aut-sei=石堂
kn-aut-mei=展宏
aut-affil-num=1
ORCID=

en-aut-name=TamuraRyuji
en-aut-sei=Tamura
en-aut-mei=Ryuji
kn-aut-name=田村竜二
kn-aut-sei=田村
kn-aut-mei=竜二
aut-affil-num=2
ORCID=

en-aut-name=OkamotoTakahiro
en-aut-sei=Okamoto
en-aut-mei=Takahiro
kn-aut-name=岡本貴大
kn-aut-sei=岡本
kn-aut-mei=貴大
aut-affil-num=3
ORCID=

en-aut-name=KadowakiYoshihiko
en-aut-sei=Kadowaki
en-aut-mei=Yoshihiko
kn-aut-name=門脇嘉彦
kn-aut-sei=門脇
kn-aut-mei=嘉彦
aut-affil-num=4
ORCID=

en-aut-name=MoriTakashi
en-aut-sei=Mori
en-aut-mei=Takashi
kn-aut-name=森隆
kn-aut-sei=森
kn-aut-mei=隆
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=神戸赤十字病院　外科

affil-num=2
en-affil=
kn-affil=神戸赤十字病院　外科

affil-num=3
en-affil=
kn-affil=神戸赤十字病院　外科

affil-num=4
en-affil=
kn-affil=神戸赤十字病院　外科

affil-num=5
en-affil=
kn-affil=神戸赤十字病院　外科
en-keyword=十二指腸潰瘍穿孔 (duodenal ulcer perforation)
kn-keyword=十二指腸潰瘍穿孔 (duodenal ulcer perforation)
en-keyword=腹腔鏡手術 (laparoscopic surgery)
kn-keyword=腹腔鏡手術 (laparoscopic surgery)
en-keyword=保存療法 (conservative therapy)
kn-keyword=保存療法 (conservative therapy)
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=2
article-no=
start-page=338
end-page=352
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1940
dt-pub=19400229
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Über die hemmende Wirkung von Solaesthiu auf die experimentelle Anaphylaxie bei Meerschweinchen
kn-title=「ソレスチン」ノ過敏症豫防機轉ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Besredka berichtete, dass Narkotika auf die Anaphylaxie hemmend wirken. Im Jahre 1929 veröffentlichte Sugimoto in unserem Institut eine Arbeit über prophylaktische Wirkung der Äthernarkose auf die Anaphylaxie bei Meerschweinchen; dabei sagte er, dass diese Wirkung im Mechanismus beruht. d.h. auf der Abschwächung der Bindungsabilitat des Präzipitins und seiner lockeren Verbindung mit Präzipitinogen. Verfasser stellte Versuche an über die prophylaktische Wirkung des Solaesthins (Methylenchlorids) auf die Anaphylaxie unter Anwendung der Ogata'schen Präzipitinverdunnungsmethode sowie seinen Einfluss auf den Peptonschock. Die Resultate lassen sich folgendermassen kurz zusammenfassen: 1) Wenn man bei aktiver Anaphylaxie von Meerschweinchen die der Bindungszone 1/2-1/4 mal entsprechende Antigenmenge reinjiziert, so tritt typischer Schocktod ein. Wenn aber das Versuchstier vor und wahrend der Reinjektion mit Solaesthin tief narkotisiert wird, treten die Symptome schwächer als bei der Kontrolle ant und erholt sich das Tier wieder. 2) Das Meerschweinchen wurde mit Antirinderserum von Kaninchen in 1:500 Prazipitineinheiten sensibilisiert und nach 24 stündiger Inkubationszeit das Antigen in einer der Bindungszone entsprechenden Menge reinjiziert. Dabei konnte man typischen Schocktod bei jedem Versuch beohachten. Wenn aber das Versuchstier vor und während der Reinjektion mit Solaesthin narkotisiert wird, treten die Symptome ganz schwach auf und die Abnahme des Präzipitins und des Komplements nach der Reinjektion ist geringer als bei der Kontrolle. Das Präzipitin und das Komplement, die sich nach der Reinjektion stark vermindern, vermehren sich langsame bei jeder Wiederholung des Symptoms. 3) Bei Solaesthinnarkose sieht man keine Abnahme des Präzipitins und des Komplements, sowohl bei aktiv als auch passiv sensibilisierten Tieren, 1 Stunde nach der Narkose zeigt sich eine geringfügige Verminderung und nach 2 Stunden ergibt sich ein gleicher Stand wie vor dem Versuch. 4) Bei den zwei Präzipitinreaktionen, wobei in einem Fall das Präzipitin mit Serum, das von Meerschweinchen während ihrer tiefen Narkose entnommen war, verdünnt wurde, im anderen Fall mit normalem Meerschweinchenserum, sieht man eine leichte Hemmung hinsichtlich der Reaktion, weil bei ersterer die Reaktion etwas langsamer als bei letzterer beobachtet wird. 5) Bei Erschütterung mit Solaesthin direkt im Serum sieht man jedoch keine hemmende Wirkung. 6) Solaesthin zeigt auch eine prophylaktische Wirkung auf den Peptonschock. 7) Aus oben erwähnten Ergebnissen schliesst Verfasser, das die prophylaktische Wirkung des Solaesthins auf die Anaphylaxie auf folgendem Mechanismus beruht: 1. Abschwächung der Bindungsabilität des Präzipitins und seine lockere Bindung mit Präzipitinogen. 2. Lähmung der bronchial glatten Muskeln wie nach den Angaben von Biedle und Kraus.
en-copyright=
kn-copyright=

en-aut-name=OnoHideo
en-aut-sei=Ono
en-aut-mei=Hideo
kn-aut-name=小野英夫
kn-aut-sei=小野
kn-aut-mei=英夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學衛生學教室
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=2
article-no=
start-page=325
end-page=337
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1940
dt-pub=19400229
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Über den Einfluss von Morphin auf die experimentelle Anaphylaxie
kn-title=「鹽酸モルヒネ」ノ過敏症ニ及ボス影響ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Besredka entdeckte, dass Äther auf die Anaphylaxie hemmend wirkt. Biedle und Kraus prüften diese interessanten Angaben nach und berichteten, das alle Narkotika (z.B. Äther Chloroform, Urethan und Alkohol u.a.) antianaphylaktisch wirken. Farmer, Aoki u.a. dagegen traten obigen Anschauungen entgegen, weil Morphin auf die Anaphylaxie keine hemmende Wirkung zeigt, sondern befördernd wirkt. Motomura, Uno und Oohira stellten fest, dass Morphin auf die Anaphylaxie doch hemmend wirkt. Verfasser untersuchte sowohl bei aktiv oder passiv präparierten Meerschweinchen als auch bei isolierten Darmschlingen die Wirkung von Morphin auf die Anaphylaxie, wobei eine bestimmte Menge von Morphin ca. 1 Stunde vor der Antigenreinjektion subkutan injiziert, den uberlebenden Darmprapäraten aber zugefuhrt wurde, und erzielte folgende Resultate: 1) Bei Vorbehandlung mit Morphin von 0.005-0.02g pro 100g Körpergewicht von Meerschweinchen erzielte man keine schockhemmende Wirkung. Aber bei Vorbehandlung mit einer relativ grossen Menge von Morphin (0.02g pro 100g Körpergewicht) ergab sich beim Versuchstier ein schwächerer Krampf als bei der Kontrolle. 2) Das Meerschweinchen wurde mit 500 Einheiten von Antirinderpräzipitin des Kaninchens vorbehandelt und nach 24 stündiger Inkubationszeit minimal tödliches Antigen (eine der Bindungszone entsprechende Menge) reinjiziert. Dabei sieht man immer typischen Schocktod bei jedem Versuchstier. Durch Vorbehandlung mit Morphin von 0.005-0.02g pro 100g Körpergewicht von Meerschweinchen wurde das Tier vom anaphylaktischen Schocktod nicht gerettet.
Wenn aber die Vorbehandiung mit Morphin relativ gross ist, bemerkt man zuweilen einen etwas schwächeren Krampf. 3) Bei aktiver und passiver Anaphylaxie von isolierten Meerschweinchendärmen sieht man bei Zufuhr von Morphin von 0, 0001-0.25% in dem Nährmedium nicht nur eine die Anaphylaxie hemmende Wirkung, sondern sogar einen etwas beförndernden Einfluss, wenn die Zufuhr von Morphin relativ gering ist. 4) Die Zufuhr von Morphin (von 0.25-0.5%) im Präzipitinverdönnungsmedium zeigt keinen besonderen Einfluss auf die Präzipitinreaktion. Aus oben erwähnten Ergebnissen schliesst Verfasser, dass durch Morphininjektion ein nennenswerter Einfluss auf die experimentelle Anaphylaxie von Meerschweinchen nicht bewirkt werden kann.
en-copyright=
kn-copyright=

en-aut-name=OnoHideo
en-aut-sei=Ono
en-aut-mei=Hideo
kn-aut-name=小野英夫
kn-aut-sei=小野
kn-aut-mei=英夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學衛生學教室
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=1
article-no=
start-page=185
end-page=203
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1940
dt-pub=19400131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Über die hemmende Wirkung des Antipyrins auf die experimentelle Anaphylasie bei Meerschweinehen
kn-title=「アンチピリン」ノ過敏症豫防機轉ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Im Jahre 1928 hat Dr. M. Matsuda berichtet, dass durch Antipyrin die Anaphylaxie stark geschützt wird und danach haben Dr. Matsuoka und Dr. Okubo dies welter nachgeprüft, aber es gibt noch keine genaue Untersuchung über den Mechanismus des Antipyrins bei der Präzipitinreaktion, womit man die Schockerscheinung in vivo nachprüfen kann. Daher studierte Verfasser unter Anwendung der Ogata'schen Methode, welche die Präzipitinmenge durch Überschichtung mit Immunkörperverdünnung bestimmt, die hemmende Wirkung des Antipyrins nach vorliegender Anschauung, ob bei dem antianaphylaktischen Vorgang des Antipyrins irgendeine hemmende Wirkung auf das Präzipitin direkt oder indirekt durch Bindung zwischen Antigen und Präzipitin beobachtet werden kann, und ferner wie sieh das Komplement dabei verhalt. 1) Bei aktiv sensibilisierten Meerschweinchen (rund 250g) wurde der Schocktod nach Antigenreinjektion (1/2-1/4 der Bindungszone entsprechende Antigenmenge) und durch vorliegende Antipyrininjektion, die mit 0.02g pro 100g Körpergewicht intravenös 5-10 Minuten vor der Reinjektion ausgeführt wurde, verhindert, wahrend das Kontrolltier an typischem Schock innerhalb 5 Minuten zugrunde ging und das Präzipitin und Komplement Bich auf fast Null verminderte. Die Abnahme des Präzipitins und des Komplements bei der Antipyrininjektion sind geringer als bei der Kontrolle. 2) Passiv sensibilisierte Meerschweinchen, welchen intravenös 500 Einheiten Immunserum injiziert wurde, wurden durch 1-1/2 der Bindungszone entsprechende Antigenreinjektion nach 24 stündiger Inkubationszeit durch typischen Schocktod abgetötet. Dagegen wurde das Tier durch Antipyrinvorinjektion in gleicher Weise wie bei der aktiven Anaphylaxie gerettet. Die Abnahme des Präzipitins und des Komplements sind dabei auch geringer als bei der Kontrolle. 3) Durch Antipyrininjektion wurde das Präzipitin nach 5 Minuten bei aktiv immunisierten Tieren ungefähr um die Halfte (1:16-1:8) vermindert und bei passiv immunisierten Tieren (1:25-I:12) sieht man eine noch grössere Verminderung. 4) Nach Antigenreinjektion wurde die Bindung zwischen Antigen und Antikörper noch gehemmt, weslialb das Präzipitin zur Kontrolle noch mehr zurückbleibt. 5) Die Präzipitinreaktion, bei der als Verdünnungsmedium Originalmeerschwein- ehenserum angewendet wird, welches 5-10 Minuten nach der Reinjektion des Antipyrins (0.02g pro 100g Körpergewicht) entnommen wird, zeigt einen viel geringeren Titer des Präzipitins und langsamere Geschwindigkeit der Reaktion als bei der Kontrolle das normale Meerschweinchenserum. 6) Bei der Reaktion, wobei Antipyrin direkt dem Medium (1% Gummi arabicum physiologische Kochsalzlüsung) zugefuhrt wird, ist auch der Präzipitintiter geringer und die Geschwindigkeit der Reaktion deutlich geringer als bei der Kontrolle.
Aus oben erwähnten Resultaten kann Verfasser den antianaphylaktischen Mechanismus des Antipyrins aus der Immunreaktion selbst durch folgende 2 Eigenschaften und zwar als einen Teil dieser Wirkung erklären. a) Hemmung der Bindung zwischen Antigen und. Antikörper. b) Langsame Bindung zwischen Antigen und Antikörper durch Veränderung des Kolloidalzustands infolge Zufuhr von Antipyrin.
en-copyright=
kn-copyright=

en-aut-name=OnoHideo
en-aut-sei=Ono
en-aut-mei=Hideo
kn-aut-name=小野英夫
kn-aut-sei=小野
kn-aut-mei=英夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學衛生學教室
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=1
article-no=
start-page=107
end-page=141
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1940
dt-pub=19400131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Serologische Studien über den Hunger (2. Mitteilung.) Über den Einfluss des Hungers auf die experimentelle Anaphylaxie
kn-title=饑餓ノ免疫學的研究（第2報）實驗的過敏症ニ及ボス饑餓ノ影響ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In der ersten Mitteilung berichtete Verfasser, dass der Hungerversuch auf die Antikörperbildung bei Tieren einen insgesamt nicht nennenswerten Einflüss ausubt, weil in bezug auf absoluten Hunger die Präzipitinbildung keinen Unterschied zeigt, während die Agglutininbildung ein wenig hemmend wirkt. In dieser Mitteilung beschäftigte er sich weiter mit der Wirkung des Hungers auf die Anaphylaxie und bemerkte einen hemmenden Einfluss des Hungers bei Meerschweinchen und Kaninchen sowohl bei aktiver und passiver Anaphylaxie als auch bei isoliertem Organversuch (Darm und Herzlungenpräparat nach Kusama und Manwaring). Die Präzipitinbestimmung und Antigenmenge zur Reinjektion wurde nach Ogata'scher Verdünnungsmethode angewandt. Die Versuchstiere wurden über 24-48 Stunden lang absolutem Hunger ausgesetzt und oben genannter Versuch angestellt. 1) Das Meerschweinchen wurde mit Antirinderpräzipitin von Kaninchen in 500 Einheiten subkutan sensibilisiert und nach 48 stündiger Inkubationszeit wurde das Antigen in einer Menge, die gemäss der Bindungszone des Präzipitins berechnet wird, intravenös injiziert. Dabei fand Verfasser bei allen Versuchstieren typischen Schocktod innerhalb 5 Minuten nach Antigenreinjektion. Wenn aber das Tier während dieser Inkubationszeit 48 Stunden in absolutem Hunger- zustand gelassen wird, so sieht man viel schwächere Symptome als bei der Kontrolle und das Tier erholt sich vom anaphylaktischen Schocktod wieder. 2) Das Meerschweinchen wurde vorher 24 stündigem absoluten Hunger ausgesetzt und dann 500 Einheiten Antirinderpräzipitin intravenös sensibilisiert. Während der 24 stündigen Inkubationszeit wurde der Hungerversuch noch fortgesetzt. Darauf wurde das Antigen nach 48 stündiger Hungerzeit und nach 24 stundiger Inkubationszeit reinjiziert. Was den Kontrollversuch bei normaler Fütterung des Tieres anbetrifft, ging dieses nach gleicher Sensibilisierung bei der Antigenreinjektion nach unserer Methode gleich an typischen Schock zugrunde. 3) Bei der aktiven Anaphylaxie der Meerschweinchen mit Rinderserum tritt der lypisch anaphylaktische Schocktod durch Reinjektion des Antigens, das 1/4 der Bindungszone entspricht, ein. Wenn aber das Versuchstier etwa 48-72 Stunden vor der Reinjektion absoluten Hunger ausgesetzt wird, zeigten sich schwächere anaphylaktische Symptome und das Versuchstier wurde vom anaphylaktischen Schocktod gerettet. Es ist merkwürdig, dass sowohl bei aktiver als auch bei passiver Anaphylaxie die Verminderung des Präzipitins nach der Antigensreinjektion beim verhungerten Tier und Kontrolltier fast gleich 4) Diese Tatsache gilt auch bei experimenteller Kaninchenanaphylaxie. Wenn man zum Versuch einem Kaninchen, welches mit Rinderserum (pro kilo 1.0cc) intravenos sensibilisiert worden war, diejenige Antigenmenge, die der Bindungszone des Serumpräzipitins entspricht, nach der Inkubation (17-18 Tage) reinjiziert, erscheint, eine dentliche Blutdrucksenkung (10-40mm).
Wenn aber das Versuchstier 5-6 Tage vor der Reiniektion absolutem Hunger ausgesetzt wird, tritt schwächere Blutdrucksenkung (0-10mm) ein, während bei dem Tiere, welches 2-3 Tage lang hungert, eine deutliche Blutdrucksenkung hervorgerufen wird. Die Abnahme des Serumpräzipitins bei diesem Experiment ist gleich wie bei der Kontrolle und wie bei der Anaphylaxie des Meerschweinchens. 5) Wie schon oben angedeutet, entspricht die hemmende Wirkung der Anaphylaxie beim verhungerten Tier nicht der verminderten Bindung zwischen Präzipitin und Antigen und ist daher nur ein kleiner Unterschied zwischen Hungertierserum und Kontrollserum als Verdünnungsmedium zur Präzipitinreaktion festzustellen. 6) Bei Peptonschock des Meerschweinchens sieht man keinen besonderen Unterschied zwischen verhungerten und normalen Tieren. Wittepepton wirkte auf das Hungerkaninchen fast gleich wie auf das normale Kaninchen in bezug auf den Blutdrucksenkungsgrad, doch auf Hungerkaninchen wirkte es langsamer als auf das normale Kaninchen, weil die Blutdrucksenkung und Wiedererhöhung desselben beim Hungertier etwas langsamer als beim normalen Tier verläuft. 7) Bei der passiven und aktiven Anaphylaxie des isolierten Meerschweinchendarmes bemerkte Verfasser beim Hungertierdarm eine gegenüber dem normalen Darm verminderte Kontraktion nach Antigenzuführung. 8) Lunge und Herz des Versuchstieres wurden mit Ringer'scher Lösung durchströmt und während der Strömung wurde die künstliche Atmung angewandt. Nach Antigenmischung mit der strömenden Flüssigkeit sieht man eine Aufblähung der Lunge beim sensibilisierten Tier. Doch ist diese Aufblähung der Lunge beim verhungerten Tier auch viel schwächer als beim normalen Tier. Oben beschriebene Ergebnisse kann man dahin zusammenfassen, dass diese antianaphylaktische Eigenschaft beim Hungertier auf die Verminderung der Reaktionsfähigkeit des Gewebes, die durch den abnormen Stoffwechsel infolge absoluten Hungers verursacht
wird, zurückzuführen ist.
en-copyright=
kn-copyright=

en-aut-name=OnoHideo
en-aut-sei=Ono
en-aut-mei=Hideo
kn-aut-name=小野英夫
kn-aut-sei=小野
kn-aut-mei=英夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學衛生學教室
END

start-ver=1.4
cd-journal=joma
no-vol=146
cd-vols=
no-issue=
article-no=
start-page=59
end-page=71
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Instructional Competence of Teachers in Lessons (Ⅳ): Lessons as Training Process
kn-title=授業における教師の指導性について(Ⅳ)ー｢練習｣過程としての授業ー
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=学枚での学習活動は少なからぬ時間が｢練習｣的な学習活動に費やされている。そこにおいて，一方で授業それ自体が全くトレーニング的なものに終始している場合もあれば，他方で｢練習｣的な学習活動にあまり注意を払わない授業論もある。学習内容には｢習熟｣を不可欠とするものがあり，そのためには｢練習｣が欠かせない。しかしその場合も機械的な｢練習｣ではなく，練習とともに｢わかる｣｢使える｣が位置づけられなくてはならない。また考え方や思考方法や学び方を深めていくという点から見れば，授業は｢練習｣過程である。練習の意味と役割を授業と関連づけて理論・実践的に整理し考察した。
en-copyright=
kn-copyright=

en-aut-name=OnoHiroo
en-aut-sei=Ono
en-aut-mei=Hiroo
kn-aut-name=小野擴男
kn-aut-sei=小野
kn-aut-mei=擴男
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院教育学研究科学校教育学系
en-keyword=練習
kn-keyword=練習
en-keyword=わかる
kn-keyword=わかる
en-keyword=活用
kn-keyword=活用
en-keyword=思考方法
kn-keyword=思考方法
en-keyword=学び方
kn-keyword=学び方
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=11-12
article-no=
start-page=1009
end-page=1014
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=198912
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Ultrastructure of the “open secretion” of beta-cell granules from Langhans' islets in Fe(3+)-NTA-treated diabetic rats
kn-title=Fe(3+)-NTA投与糖尿病ラットのβ細胞開口分泌の電顕的観察
en-subtitle=
kn-subtitle=
en-abstract=The secretion time of endocrine cells is known to be momentary. Therefore, morphologic proof of the secretory mode have relied heavily on various animal models which were treated to accelerate secretion. Ultrastructure, concerning B-cell secretion from Langhans' islets of the pancreas, has been based on immersion-fixation specimens. As an experimental model of prolonged endocrine secretion, we used rat pancreas tissues which were rapidly perfused with a fixative. The fixation process, as reported previously, was 150 ml of 2% glutaraldehyde flushed at 15 ml per minute through the ascending aorta of Fe(3+)-NTA-treated diabetic rats. Afterwards, an ultrastructural study focused on the secreting mode of beta-granules in B-cell of Langhans' islets. This procedure proved an “open secretion” of beta-granules from B-cells; this phenomenon has never been observed in the previous immersion-fixation specimens. Contrary to non-treated normal rats, the varied stages of beta-granule secretion, including immediately before as well as after the secretion, were demonstrated in Fe(3+)-NTA-treated rats. We wish to emphasize the use of rapid perfusion-fixation technique in animal models with a delayed rather than accelerated state of endocrine secretion in order to investigate ultrastractural aspects of “open secretion”.
kn-abstract=内分泌腺細胞の分泌時間は瞬時とされていることから,一般的にその分泌像の形態的観察には,分泌を促進せしめる実験系が用いられている.又膵ラ氏島B細胞分泌の超微形態は,専ら浸漬固定標本で観察されている.今回,我々は分泌が遅延している動物で,高速還流した膵ラ氏島細胞について観察した.即ち,前報と同様のFe(3+)-NTA誘発糖尿病ラットの上行大動脈より2%グルタールアルデヒド150mlを15ml/minの速度で還流固定し,ラ氏島B細胞のβ顆粒分泌像に焦点を絞って観察した.その結果,前報の浸漬固定法では観察されなかった開口分泌像が多数観察され得た.対照の健常動物に比べ, Fe(3+)-NTA投与動物では,分泌直前から分泌後に至るいろいろな段階のβ顆粒の分泌過程が観察された.以上の結果から,開口分泌像の電顕的観察にはむしろ本実験系のように細胞分泌を障害ないし低下せしめ,高速還流固定法を用いることが必要であると結論した.
en-copyright=
kn-copyright=

en-aut-name=HayashiKeiki
en-aut-sei=Hayashi
en-aut-mei=Keiki
kn-aut-name=林肇輝
kn-aut-sei=林
kn-aut-mei=肇輝
aut-affil-num=1
ORCID=

en-aut-name=ShirasugaNaoki
en-aut-sei=Shirasuga
en-aut-mei=Naoki
kn-aut-name=白須賀直樹
kn-aut-sei=白須賀
kn-aut-mei=直樹
aut-affil-num=2
ORCID=

en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=小野俊郎
kn-aut-sei=小野
kn-aut-mei=俊郎
aut-affil-num=3
ORCID=

en-aut-name=AwaiMichiyasu
en-aut-sei=Awai
en-aut-mei=Michiyasu
kn-aut-name=粟井通泰
kn-aut-sei=粟井
kn-aut-mei=通泰
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部病理学第一講座

affil-num=2
en-affil=
kn-affil=岡山大学医学部病理学第一講座

affil-num=3
en-affil=
kn-affil=岡山大学医学部病理学第一講座

affil-num=4
en-affil=
kn-affil=岡山大学医学部病理学第一講座
en-keyword=Diabetes mellitus
kn-keyword=Diabetes mellitus
en-keyword=β-cell's granules
kn-keyword=β-cell's granules
en-keyword=open secretion
kn-keyword=open secretion
en-keyword=perfusion fixation
kn-keyword=perfusion fixation
END

start-ver=1.4
cd-journal=joma
no-vol=122
cd-vols=
no-issue=3
article-no=
start-page=265
end-page=267
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20101201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Carotid artery stenosis
kn-title=頸部頸動脈狭窄症
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OkumaYu
en-aut-sei=Okuma
en-aut-mei=Yu
kn-aut-name=大熊佑
kn-aut-sei=大熊
kn-aut-mei=佑
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科学
END

start-ver=1.4
cd-journal=joma
no-vol=122
cd-vols=
no-issue=3
article-no=
start-page=231
end-page=236
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20101201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of transverse colon cancer with remarkable extramural invasion to stomach and jejunum
kn-title=壁外性に腫瘤を形成し胃・小腸浸潤を示した横行結腸癌の１例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 77-year-old woman was admitted to our hospital due to abdominal pain and body weight loss. A palpable mass the size of an infant's head was tender on palpation and identified as an epigastric lesion. Colonoscopic examination revealed stenosis of the transverse colon, although no intraluminal growth of the tumor was found. The histologic findings of the biopsy material were poorly differentiated and/or undifferentiated cells. Abdominal CT scan showed an irregular-shaped tumor with a diameter of 10cm invading the stomach and jejunum. We performed an operation under a diagnosis of extramurally growing cancer or malignant lymphoma of the colon. Partial resection of the transverse colon was done by distal gastrectomy and partial resection of the jejunum. Histologic examination of the operative specimens revealed moderately differentiated adenocarcinoma of the transverse colon, prominently proliferating into the surrounding tissues. The finding of a long stenotic lesion and extramural compression by colonography are characteristic of this tumor, based on a review of 43 literature reports in Japan.
en-copyright=
kn-copyright=

en-aut-name=HamanoRyosuke
en-aut-sei=Hamano
en-aut-mei=Ryosuke
kn-aut-name=濱野亮輔
kn-aut-sei=濱野
kn-aut-mei=亮輔
aut-affil-num=1
ORCID=

en-aut-name=OtsukaShinya
en-aut-sei=Otsuka
en-aut-mei=Shinya
kn-aut-name=大塚眞哉
kn-aut-sei=大塚
kn-aut-mei=眞哉
aut-affil-num=2
ORCID=

en-aut-name=KimuraYuuji
en-aut-sei=Kimura
en-aut-mei=Yuuji
kn-aut-name=木村裕司
kn-aut-sei=木村
kn-aut-mei=裕司
aut-affil-num=3
ORCID=

en-aut-name=NishieManabu
en-aut-sei=Nishie
en-aut-mei=Manabu
kn-aut-name=西江学
kn-aut-sei=西江
kn-aut-mei=学
aut-affil-num=4
ORCID=

en-aut-name=TokunagaNaoyuki
en-aut-sei=Tokunaga
en-aut-mei=Naoyuki
kn-aut-name=徳永尚之
kn-aut-sei=徳永
kn-aut-mei=尚之
aut-affil-num=5
ORCID=

en-aut-name=MiyasouHideaki
en-aut-sei=Miyasou
en-aut-mei=Hideaki
kn-aut-name=宮宗秀明
kn-aut-sei=宮宗
kn-aut-mei=秀明
aut-affil-num=6
ORCID=

en-aut-name=TsunemituYousuke
en-aut-sei=Tsunemitu
en-aut-mei=Yousuke
kn-aut-name=常光洋輔
kn-aut-sei=常光
kn-aut-mei=洋輔
aut-affil-num=7
ORCID=

en-aut-name=InagakiMasaru
en-aut-sei=Inagaki
en-aut-mei=Masaru
kn-aut-name=稲垣優
kn-aut-sei=稲垣
kn-aut-mei=優
aut-affil-num=8
ORCID=

en-aut-name=IwakawaKazuhide
en-aut-sei=Iwakawa
en-aut-mei=Kazuhide
kn-aut-name=岩川和秀
kn-aut-sei=岩川
kn-aut-mei=和秀
aut-affil-num=9
ORCID=

en-aut-name=IwagakiHiromi
en-aut-sei=Iwagaki
en-aut-mei=Hiromi
kn-aut-name=岩垣博巳
kn-aut-sei=岩垣
kn-aut-mei=博巳
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=2
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=3
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=4
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=5
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=6
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=7
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=8
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=9
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=10
en-affil=
kn-affil=国立病院機構福山医療センター　外科
en-keyword=大腸癌 (colon cancer)
kn-keyword=大腸癌 (colon cancer)
en-keyword=壁外性発育 (extraluminal growth)
kn-keyword=壁外性発育 (extraluminal growth)
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=
article-no=
start-page=77
end-page=80
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1953
dt-pub=195306
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A CASE OF LUNG-CYST
kn-title=嚢胞肺の一例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author reported a patient, aged 32, with many cysts in his left lung. Since he had suffered from fever in suckling age, he caught cold often. bnt was not confined to his bed. A physician diagnosed him as lung tuberculosis on a recent occasion of health examination but intracutaneous tuberculin-reaction and tuberculous bacilli in sputum proved negative. Many cysts of variable sizes with niveau were recognized by means of bronchograph. Wassermann's reaction in serum was positive. By penicillin-therapy his main complaint of thorakalgia and much expectoration was markedly diminished.
en-copyright=
kn-copyright=

en-aut-name=OnodaSusumu
en-aut-sei=Onoda
en-aut-mei=Susumu
kn-aut-name=小野田進
kn-aut-sei=小野田
kn-aut-mei=進
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学溫泉研究所内科
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=
article-no=
start-page=66
end-page=71
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1953
dt-pub=195306
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=SEASONAL CHANGES IN THE AVERAGE ERYTHROCYTES SEDIMENTATION RATE IN MISASA, TOTTORI-PREFECTURE
kn-title=赤血球沈降速度の季節的動搖
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Measuring erythrocytes sedimentation rate (E.S.R.) at a constant temperature (37°C) in Misasa, Tottori-Prefecture, the author recognized seasonal fluctuations in the average E.S.R. E.S.R. in Misasa has a tendency to increase in winter than in summer, contrary to the former observations in other districts of Japan. And concerning this contradiction the author calls attention to the effect of the climatological
characteristics in Tottori-Prefecture, e.g. relative high humidity in winter in this district, compared with the relative low humidity in the other (southern eastern part of Japan).
en-copyright=
kn-copyright=

en-aut-name=OnodaSusumu
en-aut-sei=Onoda
en-aut-mei=Susumu
kn-aut-name=小野田進
kn-aut-sei=小野田
kn-aut-mei=進
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学溫泉研究所内科
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=
article-no=
start-page=17
end-page=27
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1953
dt-pub=195303
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=PROTECTIVE EFFECT OF THERMAL BATHS AGAINST TOTAL BODY-X-IRRADIATION
kn-title=レ線障碍に及ぼす温泉浴の効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author investigated the effect of a series of thermal baths of Misasa (at 37°C for ten minutes) during ten days on the survival rate and fat index of liver in X-irradiated mice. The radioactive thermal baths prior to or following a lethal dose of total body X-irradiation (800r) were not able to modify the survival or death rate in mice. The radioactive thermal baths prior to LD 50 dose of X-irradiation (450r) improved the survival rate and decreased the liver injury. But the thermal haths following the same dose of
X-irradiation showed no protective effect and seemed to increase the injury of X-irradiation rather. The combination of thermal baths for ten days and daily X-irradiation of 50r for the successive 25 days produced more unfavourable result than control without baths. On the contrary thermal baths prior to the daily X-irradiation of 50r showed a marked protection concerning the lethal effect and fat index of liver in mice. Three kinds of baths were used in this experiment, namely natural strongly radioactive thermal bath of Misasa (50-80m. m. curies Rn per liter). natural weakly radioactive thermal bath (5-10m. m. curie; Rn per liter) and plain water bath. But no significant difference
was proved between the effects of these three kinds of baths.
en-copyright=
kn-copyright=

en-aut-name=OnodaSusumu
en-aut-sei=Onoda
en-aut-mei=Susumu
kn-aut-name=小野田進
kn-aut-sei=小野田
kn-aut-mei=進
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学溫泉研究所内科
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=
article-no=
start-page=33
end-page=33
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1957
dt-pub=195709
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=花崗岩に関する諸問題　（7）　花崗岩中の斜長石の組成の一例（要旨）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=末野悌六
kn-aut-sei=末野
kn-aut-mei=悌六
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=小野田セメント株式会社
END

start-ver=1.4
cd-journal=joma
no-vol=144
cd-vols=
no-issue=
article-no=
start-page=13
end-page=25
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100625
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Instructional Competence of Teachers in Lessons (III) : With Focus on Acquisition of Fundamentals and Basics and Communicative Instruction
kn-title=授業における教師の指導性について（Ⅲ）―｢基礎･基本｣の習得と｢授業展開｣―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=今日,基礎的･基本的な内容についての学習が一方では機械的なトレーニングとして,また他方ではその内容を軽視した話し合い活動のための単なる素材として取り扱われる傾向がある｡これは知識や技能の｢習得｣と｢活用｣のとらえ方と無関係ではない｡前者は｢活用｣の基礎に練習･記憶による｢習得｣を位置づけ,後者は豊か思考活動に重きをおいて｢習得｣や達成についてはあまり配慮を加えない｡こうしたあり方に対して,｢習得｣も｢活用｣もバランスよく指導することが重要であるともされるが,問題の本質は量的なバランス論にあるのではない｡今日の授業の基本的課題として重要なことは,｢基礎的･基本的な内容｣に込められている意味を確認し,これまでの日本の授業実践の蓄積を読み直すことによって,｢基礎的･基本的な内容｣の豊かな習得を保障する｢授業展開｣の仕組みを明らかにすることである｡
en-copyright=
kn-copyright=

en-aut-name=OnoHiroo
en-aut-sei=Ono
en-aut-mei=Hiroo
kn-aut-name=小野擴男
kn-aut-sei=小野
kn-aut-mei=擴男
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院教育学研究科学校教育学系
en-keyword=基礎
kn-keyword=基礎
en-keyword=基本
kn-keyword=基本
en-keyword=授業展開
kn-keyword=授業展開
en-keyword=発問
kn-keyword=発問
en-keyword=学習形態
kn-keyword=学習形態
END

start-ver=1.4
cd-journal=joma
no-vol=122
cd-vols=
no-issue=2
article-no=
start-page=129
end-page=133
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100802
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of superior mesenteric artery syndrome after left hemicolectomy for descending colon cancer
kn-title=保存的治療が可能であった左半結腸切除後上腸間膜動脈症候群の1例：本邦報告47例の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 58-year-old man was diagnosed as having descending colon cancer and underwent a left colectomy with D3 node dissection and end-to-end anastomosis reconstruction. The accessory middle colic artery was secured as a feeding artery, and the middle colic artery was preserved. Diet was started on postoperative day 5 (POD5), and nausea and vomiting appeared on POD10. An upper gastrointestinal series revealed to-and-fro peristalsis in the third portion of the duodenum and dilatation of the proximal duodenum. Abdominal CT showed that the second portion of the duodenum was markedly dilated and the third portion was compressed by the superior mesenteric artery (SMA). As a result, he was diagnosed with post-operative superior mesenteric artery syndrome (SMAS) and treated with conservative therapy. The symptoms improved with a nasogastric tube, and he started to eat after POD26, followed by a successful outcome.
en-copyright=
kn-copyright=

en-aut-name=HamanoRyousuke
en-aut-sei=Hamano
en-aut-mei=Ryousuke
kn-aut-name=濱野亮輔
kn-aut-sei=濱野
kn-aut-mei=亮輔
aut-affil-num=1
ORCID=

en-aut-name=OtsukaShinya
en-aut-sei=Otsuka
en-aut-mei=Shinya
kn-aut-name=大塚眞哉
kn-aut-sei=大塚
kn-aut-mei=眞哉
aut-affil-num=2
ORCID=

en-aut-name=NishieManabu
en-aut-sei=Nishie
en-aut-mei=Manabu
kn-aut-name=西江学
kn-aut-sei=西江
kn-aut-mei=学
aut-affil-num=3
ORCID=

en-aut-name=NomuraTsunehisa
en-aut-sei=Nomura
en-aut-mei=Tsunehisa
kn-aut-name=野村長久
kn-aut-sei=野村
kn-aut-mei=長久
aut-affil-num=4
ORCID=

en-aut-name=TokunagaNaoyuki
en-aut-sei=Tokunaga
en-aut-mei=Naoyuki
kn-aut-name=徳永尚之
kn-aut-sei=徳永
kn-aut-mei=尚之
aut-affil-num=5
ORCID=

en-aut-name=MiyasouHideaki
en-aut-sei=Miyasou
en-aut-mei=Hideaki
kn-aut-name=宮宗秀明
kn-aut-sei=宮宗
kn-aut-mei=秀明
aut-affil-num=6
ORCID=

en-aut-name=TakahashiKenji
en-aut-sei=Takahashi
en-aut-mei=Kenji
kn-aut-name=高橋健司
kn-aut-sei=高橋
kn-aut-mei=健司
aut-affil-num=7
ORCID=

en-aut-name=TsunemitsuYousuke
en-aut-sei=Tsunemitsu
en-aut-mei=Yousuke
kn-aut-name=常光洋輔
kn-aut-sei=常光
kn-aut-mei=洋輔
aut-affil-num=8
ORCID=

en-aut-name=MiyoshiKazuya
en-aut-sei=Miyoshi
en-aut-mei=Kazuya
kn-aut-name=三好和也
kn-aut-sei=三好
kn-aut-mei=和也
aut-affil-num=9
ORCID=

en-aut-name=InagakiMasaru
en-aut-sei=Inagaki
en-aut-mei=Masaru
kn-aut-name=稲垣優
kn-aut-sei=稲垣
kn-aut-mei=優
aut-affil-num=10
ORCID=

en-aut-name=IwakawaKazuhide
en-aut-sei=Iwakawa
en-aut-mei=Kazuhide
kn-aut-name=岩川和秀
kn-aut-sei=岩川
kn-aut-mei=和秀
aut-affil-num=11
ORCID=

en-aut-name=TakahashiMasahiko
en-aut-sei=Takahashi
en-aut-mei=Masahiko
kn-aut-name=高橋正彦
kn-aut-sei=高橋
kn-aut-mei=正彦
aut-affil-num=12
ORCID=

en-aut-name=IwagakiHiromi
en-aut-sei=Iwagaki
en-aut-mei=Hiromi
kn-aut-name=岩垣博巳
kn-aut-sei=岩垣
kn-aut-mei=博巳
aut-affil-num=13
ORCID=

affil-num=1
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=2
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=3
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=4
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=5
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=6
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=7
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=8
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=9
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=10
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=11
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=12
en-affil=
kn-affil=国立病院機構福山医療センター　外科

affil-num=13
en-affil=
kn-affil=国立病院機構福山医療センター　外科
en-keyword=上腸間膜動脈症候群 (superior mesenteric artery syndrome)
kn-keyword=上腸間膜動脈症候群 (superior mesenteric artery syndrome)
en-keyword=大腸癌 (colon cancer)
kn-keyword=大腸癌 (colon cancer)
END

start-ver=1.4
cd-journal=joma
no-vol=63
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=7
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=200902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Protein Transduction Method for Cerebrovascular Disorders
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Many studies have shown that a motif of 11 consecutive arginines (11R) is one of the most effective protein transduction domains (PTD) for introducing proteins into the cell membrane. By conjugating this &#34;11R&#34;, all sorts of proteins can effectively and harmlessly be transferred into any kind of cell. We therefore examined the transduction efficiency of 11R in cerebral arteries and obtained results showing that 11R fused enhanced green fluorescent protein (11R-EGFP) immediately and effectively penetrated all layers of the rat basilar artery (BA), especially the tunica media. This method provides a revolutionary approach to cerebral arteries and ours is the first study to demonstrate the successful transductionof a PTD fused protein into the cerebral arteries. In this review, we present an outline of our studies and other key studies related to cerebral vasospasm and 11R, problems to be overcome, and predictions regarding future use of the 11R protein transduction method for cerebral vasospasm (CV).</p>
en-copyright=
kn-copyright=

en-aut-name=OgawaTomoyuki
en-aut-sei=Ogawa
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OnoShigeki
en-aut-sei=Ono
en-aut-mei=Shigeki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IchikawaTomotsugu
en-aut-sei=Ichikawa
en-aut-mei=Tomotsugu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ArimitsuSeiji
en-aut-sei=Arimitsu
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OnodaKeisuke
en-aut-sei=Onoda
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TokunagaKoji
en-aut-sei=Tokunaga
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SugiuKenji
en-aut-sei=Sugiu
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TomizawaKazuhito
en-aut-sei=Tomizawa
en-aut-mei=Kazuhito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MatsuiHideki
en-aut-sei=Matsui
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=DateIsao
en-aut-sei=Date
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=2
en-affil=
kn-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=3
en-affil=
kn-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=4
en-affil=
kn-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=5
en-affil=
kn-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=6
en-affil=
kn-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=7
en-affil=
kn-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=8
en-affil=
kn-affil=Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=9
en-affil=
kn-affil=Department of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=10
en-affil=
kn-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
en-keyword=cerebral vasospasm
kn-keyword=cerebral vasospasm
en-keyword=11 consecutive arginines (11R)
kn-keyword=11 consecutive arginines (11R)
en-keyword=enhanced green fluorescent protein (EGFP)
kn-keyword=enhanced green fluorescent protein (EGFP)
END

start-ver=1.4
cd-journal=joma
no-vol=48
cd-vols=
no-issue=5
article-no=
start-page=279
end-page=282
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=199410
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Allergens of the house dust mite, Dermatophagoides pteronyssinus, in patients with mite allergic rhinitis: a clinical investigation by intracutaneous skin tests and nasal provocation tests.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>To determine the allergens of mite allergic rhinitis, we studied 31 patients with mite allergic rhinitis by skin tests and nasal provocation tests (15 for skin and 16 for nasal tests) using 6 fractions of Dermatophagoides pteronyssinus (Dp) extract differing in molecular weights (15, 25, 32, 53, 95 and 190 kDMW). In skin testing, patients showed intense positive reactions to the fractions of 15, 25, 32, 95 and 190 kDMW, among which the most patients showed positive reactions to the fractions of 15 and 25 kDMW. Significant differences were found in patients' positive reactivity among each fraction and between low (15 and 25 kD) and high (95 and 190 kD) molecular weight fractions as well. In nasal provocation tests, patients showed intense positive reactions to the fractions of 15, 32, 53 and 95 kDMW, especially to the fractions of 15 and 95 kDMW. Furthermore, the insidence of positive reactions to the 15 kDMW fraction was significantly higher than that to any other fraction in the skin tests (P &#60; 0.05). From these results, the low molecular weight fraction, 15 kDMW, is considered to be the main allergen of this mite and the high molecular weight fractions, 95 and 190 kDMW, may also be considered to be allergens of this mite.</p>

en-copyright=
kn-copyright=

en-aut-name=NishiokaKeiko
en-aut-sei=Nishioka
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SaitoChisato
en-aut-sei=Saito
en-aut-mei=Chisato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NaganoToshiaki
en-aut-sei=Nagano
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OkanoMitsuhiro
en-aut-sei=Okano
en-aut-mei=Mitsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakagawaFumio
en-aut-sei=Nakagawa
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NishiokaSatoko
en-aut-sei=Nishioka
en-aut-mei=Satoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MasudaYu
en-aut-sei=Masuda
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=Hiroshima City Hospital

affil-num=2
en-affil=
kn-affil=Okayama City Hospital

affil-num=3
en-affil=
kn-affil=Okayama Univeristy

affil-num=4
en-affil=
kn-affil=Okayama Uniiversity

affil-num=5
en-affil=
kn-affil=Okayama University

affil-num=6
en-affil=
kn-affil=Okayama University 

affil-num=7
en-affil=
kn-affil=Okayama University 

affil-num=8
en-affil=
kn-affil=Okayama University
en-keyword=mite allergen
kn-keyword=mite allergen
en-keyword=skin test
kn-keyword=skin test
en-keyword=nasal provoration test
kn-keyword=nasal provoration test
en-keyword=allergen rhinitis
kn-keyword=allergen rhinitis
END

start-ver=1.4
cd-journal=joma
no-vol=48
cd-vols=
no-issue=5
article-no=
start-page=279
end-page=282
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=199410
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Allergens of the house dust mite, Dermatophagoides pteronyssinus, in patients with mite allergic rhinitis: a clinical investigation by intracutaneous skin tests and nasal provocation tests.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>To determine the allergens of mite allergic rhinitis, we studied 31 patients with mite allergic rhinitis by skin tests and nasal provocation tests (15 for skin and 16 for nasal tests) using 6 fractions of Dermatophagoides pteronyssinus (Dp) extract differing in molecular weights (15, 25, 32, 53, 95 and 190 kDMW). In skin testing, patients showed intense positive reactions to the fractions of 15, 25, 32, 95 and 190 kDMW, among which the most patients showed positive reactions to the fractions of 15 and 25 kDMW. Significant differences were found in patients' positive reactivity among each fraction and between low (15 and 25 kD) and high (95 and 190 kD) molecular weight fractions as well. In nasal provocation tests, patients showed intense positive reactions to the fractions of 15, 32, 53 and 95 kDMW, especially to the fractions of 15 and 95 kDMW. Furthermore, the insidence of positive reactions to the 15 kDMW fraction was significantly higher than that to any other fraction in the skin tests (P &#60; 0.05). From these results, the low molecular weight fraction, 15 kDMW, is considered to be the main allergen of this mite and the high molecular weight fractions, 95 and 190 kDMW, may also be considered to be allergens of this mite.</p>

en-copyright=
kn-copyright=

en-aut-name=NishiokaKeiko
en-aut-sei=Nishioka
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SaitoChisato
en-aut-sei=Saito
en-aut-mei=Chisato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NaganoToshiaki
en-aut-sei=Nagano
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OkanoMitsuhiro
en-aut-sei=Okano
en-aut-mei=Mitsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakagawaFumio
en-aut-sei=Nakagawa
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NishiokaSatoko
en-aut-sei=Nishioka
en-aut-mei=Satoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MasudaYu
en-aut-sei=Masuda
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=Hiroshima City Hospital

affil-num=2
en-affil=
kn-affil=Okayama City Hospital

affil-num=3
en-affil=
kn-affil=Okayama Univeristy

affil-num=4
en-affil=
kn-affil=Okayama  University

affil-num=5
en-affil=
kn-affil=Okayama University

affil-num=6
en-affil=
kn-affil=Okayama University 

affil-num=7
en-affil=
kn-affil=Okayama University

affil-num=8
en-affil=
kn-affil=Okayama University
en-keyword=mite allergen
kn-keyword=mite allergen
en-keyword=skin test
kn-keyword=skin test
en-keyword=nasal provoration test
kn-keyword=nasal provoration test
en-keyword=allergen rhinitis
kn-keyword=allergen rhinitis
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=20050120
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Functional promoter upstream p53 regulatory sequence of IGFBP3 that is silenced by tumor specific methylation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p><b>Background:</b> Insulin-like growth factor binding protein (IGFBP)-3 functions as a carrier of insulinlike
growth factors (IGF<sub>s</sub>) in circulation and a mediator of the growth suppression signal in cells. There are two reported p53 regulatory regions in the IGFBP3 gene; one upstream of the promoter and one intronic. We previously reported a hot spot of promoter hypermethylation of IGFBP-3 in
human hepatocellular carcinomas and derivative cell lines. As the hot spot locates at the putative upstream p53 consensus sequences, these p53 consensus sequences are really functional is a question to be answered.<br />
<b>Methods:</b> In this study, we examined the p53 consensus sequences upstream of the IGFBP-3 promoter for the p53 induced expression of IGFBP-3. Deletion, mutagenesis, and methylation
constructs of IGFBP-3 promoter were assessed in the human hepatoblastoma cell line HepG2 for promoter activity.<br />
Results: Deletions and mutations of these sequences completely abolished the expression of IGFBP-3 in the presence of p53 overexpression. In vitro methylation of these p53 consensus
sequences also suppressed IGFBP-3 expression. In contrast, the expression of IGFBP-3 was not affected in the absence of p53 overexpression. Further, we observed by electrophoresis mobility
shift assay that p53 binding to the promoter region was diminished when methylated.<br />
<b>Conclusion:</b> From these observations, we conclude that four out of eleven p53 consensus sequences upstream of the IGFBP-3 promoter are essential for the p53 induced expression of
IGFBP-3, and hypermethylation of these sequences selectively suppresses p53 induced IGFBP-3 expression in HepG2 cells.</p>
en-copyright=
kn-copyright=

en-aut-name=HanafusaTadashi
en-aut-sei=Hanafusa
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShinjiToshiyuki
en-aut-sei=Shinji
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShirahaHidenori
en-aut-sei=Shiraha
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NousoKazuhiro
en-aut-sei=Nouso
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IwasakiYoshiaki
en-aut-sei=Iwasaki
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YumotoEichiro
en-aut-sei=Yumoto
en-aut-mei=Eichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KoideNorio
en-aut-sei=Koide
en-aut-mei=Norio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University Advanced Science Research Center, Department of Radiation Research, Shikata Laboratory

affil-num=2
en-affil=
kn-affil=Department of Laboratory Medicine, Okayama University Graduate School of Medicine and Dentistry

affil-num=3
en-affil=
kn-affil=First Department of Internal Medicine, Okayama University Graduate School of Medicine and Dentistry

affil-num=4
en-affil=
kn-affil=First Department of Internal Medicine, Okayama University Graduate School of Medicine and Dentistry

affil-num=5
en-affil=
kn-affil=First Department of Internal Medicine, Okayama University Graduate School of Medicine and Dentistry

affil-num=6
en-affil=
kn-affil=First Department of Internal Medicine, Okayama University Graduate School of Medicine and Dentistry

affil-num=7
en-affil=
kn-affil=Okayama University Advanced Science Research Center, Department of Radiation Research, Shikata Laboratory

affil-num=8
en-affil=
kn-affil=Department of Laboratory Medicine, Okayama University Graduate School of Medicine and Dentistry
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=40
end-page=42
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=198604
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=阪大微生物病研究会　観音寺研究所雲岡支所
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=AndoTadashi
en-aut-sei=Ando
en-aut-mei=Tadashi
kn-aut-name=安藤忠司
kn-aut-sei=安藤
kn-aut-mei=忠司
aut-affil-num=1
ORCID=

en-aut-name=OnoKoichi
en-aut-sei=Ono
en-aut-mei=Koichi
kn-aut-name=小野耕一
kn-aut-sei=小野
kn-aut-mei=耕一
aut-affil-num=2
ORCID=

en-aut-name=YoshidaIwao
en-aut-sei=Yoshida
en-aut-mei=Iwao
kn-aut-name=吉田巌
kn-aut-sei=吉田
kn-aut-mei=巌
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=林政実
kn-aut-sei=林
kn-aut-mei=政実
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=入江進一
kn-aut-sei=入江
kn-aut-mei=進一
aut-affil-num=5
ORCID=

en-aut-name=KonobeTakeo
en-aut-sei=Konobe
en-aut-mei=Takeo
kn-aut-name=高延壮男
kn-aut-sei=高延
kn-aut-mei=壮男
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=財団法人　阪大微生物病研究会

affil-num=2
en-affil=
kn-affil=財団法人　阪大微生物病研究会

affil-num=3
en-affil=
kn-affil=財団法人　阪大微生物病研究会

affil-num=4
en-affil=
kn-affil=財団法人　阪大微生物病研究会

affil-num=5
en-affil=
kn-affil=財団法人　阪大微生物病研究会

affil-num=6
en-affil=
kn-affil=財団法人　阪大微生物病研究会
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=
article-no=
start-page=8
end-page=14
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1995
dt-pub=199507
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=実験動物とワクチンの品質管理―日本脳炎ワクチン力価試験用マウスの検討―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnoKoichi
en-aut-sei=Ono
en-aut-mei=Koichi
kn-aut-name=小野耕一
kn-aut-sei=小野
kn-aut-mei=耕一
aut-affil-num=1
ORCID=

en-aut-name=OnishiToshiyuki
en-aut-sei=Onishi
en-aut-mei=Toshiyuki
kn-aut-name=大西敏之
kn-aut-sei=大西
kn-aut-mei=敏之
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=財団法人阪大微生物病研究会観音寺研究所

affil-num=2
en-affil=
kn-affil=財団法人阪大微生物病研究会観音寺研究所
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=
article-no=
start-page=1
end-page=61
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090916
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=「歴史遺産の保全と活用をめぐる地域ネットワークに関する研究」岡山史料ネットIII
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ImazuKatsunori
en-aut-sei=Imazu
en-aut-mei=Katsunori
kn-aut-name=今津勝紀
kn-aut-sei=今津
kn-aut-mei=勝紀
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=
article-no=
start-page=13
end-page=22
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19931215
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Monitoring of Environmental Ionizing Radiation and Radioisotopes in Okayama City and the Vicinty (I)
kn-title=岡山市周辺の環境放射線ならびに放射能の調査・研究(I)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TadaMikiro
en-aut-sei=Tada
en-aut-mei=Mikiro
kn-aut-name=多田幹郎
kn-aut-sei=多田
kn-aut-mei=幹郎
aut-affil-num=1
ORCID=

en-aut-name=OnoBun-ichiro
en-aut-sei=Ono
en-aut-mei=Bun-ichiro
kn-aut-name=小野文一郎
kn-aut-sei=小野
kn-aut-mei=文一郎
aut-affil-num=2
ORCID=

en-aut-name=KanayamaMunetoshi
en-aut-sei=Kanayama
en-aut-mei=Munetoshi
kn-aut-name=鑛山宗利
kn-aut-sei=鑛山
kn-aut-mei=宗利
aut-affil-num=3
ORCID=

en-aut-name=HachiyaKinji
en-aut-sei=Hachiya
en-aut-mei=Kinji
kn-aut-name=蜂谷欽司
kn-aut-sei=蜂谷
kn-aut-mei=欽司
aut-affil-num=4
ORCID=

en-aut-name=SatohKimiyuki
en-aut-sei=Satoh
en-aut-mei=Kimiyuki
kn-aut-name=佐藤公行
kn-aut-sei=佐藤
kn-aut-mei=公行
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学農学部

affil-num=2
en-affil=
kn-affil=岡山大学薬学部

affil-num=3
en-affil=
kn-affil=岡山大学RI共同利用津島施設

affil-num=4
en-affil=
kn-affil=岡山大学RI共同利用津島施設

affil-num=5
en-affil=
kn-affil=岡山大学理学部
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=
article-no=
start-page=3
end-page=10
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=19941225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Monitoring of Environmental Ionizing Radiation and Radioisotopes in Okayama City and the Vicinty (II) - An estimation of the external radiation from the environmental radiation dose -
kn-title=岡山市周辺の環境放射線ならびに放射能の調査・研究（II）―環境レベルの空間線量からの外部被曝に関する評価―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Monitoring of environmental ionizing radiation and radioisotopes in Okayama city and the vicinity was carried out from the point of view of the external radiation from the environmental radiation dose. Although the fluctuation of monthly detected radiation dose throughout the year was rather low at each observation point, the mean value of dose equivalent was varied between the place of observation. From the observation of the distribution of environmental radiation dose in Okayama city, it was assumed that its distribution was well corresponded with the distribution of igneous rocks. The concentrations of radioisotopes in various kinds of rocks corrected in Okayama city and its vicinity were determined. It became apparent that high concentrations of radioisotopes, such as (134)Cs, (40)K, (226)Ra and (228)Th, were detected in igneous rocks, such as granite, gabbro and rhyolitic tuff, although the contents in sedimentary rocks, such as pelite, schist, psammite and limestone, were rather low. This result was in good agreement with that of the distribution of radiation dose in Okayama city.
en-copyright=
kn-copyright=

en-aut-name=MioMitsunobu
en-aut-sei=Mio
en-aut-mei=Mitsunobu
kn-aut-name=見尾光庸
kn-aut-sei=見尾
kn-aut-mei=光庸
aut-affil-num=1
ORCID=

en-aut-name=KanayamaMunetoshi
en-aut-sei=Kanayama
en-aut-mei=Munetoshi
kn-aut-name=鑛山宗利
kn-aut-sei=鑛山
kn-aut-mei=宗利
aut-affil-num=2
ORCID=

en-aut-name=TadaMikiro
en-aut-sei=Tada
en-aut-mei=Mikiro
kn-aut-name=多田幹郎
kn-aut-sei=多田
kn-aut-mei=幹郎
aut-affil-num=3
ORCID=

en-aut-name=OnoBun-ichiro
en-aut-sei=Ono
en-aut-mei=Bun-ichiro
kn-aut-name=小野文一郎
kn-aut-sei=小野
kn-aut-mei=文一郎
aut-affil-num=4
ORCID=

en-aut-name=HachiyaKinji
en-aut-sei=Hachiya
en-aut-mei=Kinji
kn-aut-name=蜂谷欽司
kn-aut-sei=蜂谷
kn-aut-mei=欽司
aut-affil-num=5
ORCID=

en-aut-name=SatohKimiyuki
en-aut-sei=Satoh
en-aut-mei=Kimiyuki
kn-aut-name=佐藤公行
kn-aut-sei=佐藤
kn-aut-mei=公行
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学薬学部

affil-num=2
en-affil=
kn-affil=岡山大学RI共同利用津島施設

affil-num=3
en-affil=
kn-affil=岡山大学農学部

affil-num=4
en-affil=
kn-affil=岡山大学薬学部

affil-num=5
en-affil=
kn-affil=岡山大学RI共同利用津島施設

affil-num=6
en-affil=
kn-affil=岡山大学理学部
END

start-ver=1.4
cd-journal=joma
no-vol=22
cd-vols=
no-issue=
article-no=
start-page=26
end-page=31
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2000
dt-pub=200009
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Evaluation of genotoxic potential in sewage and treated effluent with the umu-test
kn-title=Umu試験による生活系排水の遺伝毒性評価
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The umu-test, which can detect genotoxic activites of a wide variety of environmental carcinogens and mutagenes, was carried out with samples from several sewage treatment processes. We applied the umu-test to raw sewage and treated effluent from two points of view, one is to evaluate a treatment process and the other is to identify the genotoxic substances. The original strain of umu-test, Salmonella typhimurium TA1535/pSK1002 can detect nonspecific genotoxicity, on the other hand, by using S. typhimurium NM2009 of the umu-test highly sensitive to aromatic amines, genotoxicity related to aromatic amines is measured. The result showed that genotoxic substances which have the polycyclic aromatic amino structures in the sewage remained after biological treatment. Tow-step HPLC fractionation followed by MS analysis to identify the genotoxic substances was applied to samples to detect mutagenic and carcinogenic heterocyclic amines. The concentration of Trp-P-1 and Trp-P-2 determined in the effluent caluculated from HPLC-UV analysis were on the order of 10(-5) mg/L. Because of the possibility of the reuse of wastewater in urban areas, the need for the investigation of the safety of the treated water from the sewage treatment plants was suggested, in order to evaluate strategies for advanced treatment, if necessary.
en-copyright=
kn-copyright=

en-aut-name=MohriShino
en-aut-sei=Mohri
en-aut-mei=Shino
kn-aut-name=毛利紫乃
kn-aut-sei=毛利
kn-aut-mei=紫乃
aut-affil-num=1
ORCID=

en-aut-name=OnoYoshiro
en-aut-sei=Ono
en-aut-mei=Yoshiro
kn-aut-name=小野芳朗
kn-aut-sei=小野
kn-aut-mei=芳朗
aut-affil-num=2
ORCID=

en-aut-name=KawaraOsami
en-aut-sei=Kawara
en-aut-mei=Osami
kn-aut-name=河原長美
kn-aut-sei=河原
kn-aut-mei=長美
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院自然科学研究科

affil-num=2
en-affil=
kn-affil=岡山大学環境理工学部環境デザイン工学科

affil-num=3
en-affil=
kn-affil=岡山大学環境理工学部環境デザイン工学科
END

start-ver=1.4
cd-journal=joma
no-vol=20
cd-vols=
no-issue=
article-no=
start-page=28
end-page=32
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=200309
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Possibilities of Weak Acid Hypochlorous Water for Hygiene Control in the Laboratory Animal Facilities - Practical Use as a Substitution for Formaldehyde Fumigation - Application for Sewage Disposal System ofAnimal Facilities -
kn-title=弱敵性次亜塩素酸水を用いた動物実験施設での衛生管理の可能性―ホルマリン燻蒸に替わる新たな消毒資材としての活用飼育　汚物排水の消毒処理への応用の可能性―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YamashitaKouji
en-aut-sei=Yamashita
en-aut-mei=Kouji
kn-aut-name=山下光治
kn-aut-sei=山下
kn-aut-mei=光治
aut-affil-num=1
ORCID=

en-aut-name=MiyakeMana
en-aut-sei=Miyake
en-aut-mei=Mana
kn-aut-name=三宅真名
kn-aut-sei=三宅
kn-aut-mei=真名
aut-affil-num=2
ORCID=

en-aut-name=OnoTomoko
en-aut-sei=Ono
en-aut-mei=Tomoko
kn-aut-name=小野朋子
kn-aut-sei=小野
kn-aut-mei=朋子
aut-affil-num=3
ORCID=

en-aut-name=NasuHaruaki
en-aut-sei=Nasu
en-aut-mei=Haruaki
kn-aut-name=那須玄明
kn-aut-sei=那須
kn-aut-mei=玄明
aut-affil-num=4
ORCID=

en-aut-name=ShigemotoMasayuki
en-aut-sei=Shigemoto
en-aut-mei=Masayuki
kn-aut-name=重本雅之
kn-aut-sei=重本
kn-aut-mei=雅之
aut-affil-num=5
ORCID=

en-aut-name=HashimotoHaruo
en-aut-sei=Hashimoto
en-aut-mei=Haruo
kn-aut-name=橋本晴夫
kn-aut-sei=橋本
kn-aut-mei=晴夫
aut-affil-num=6
ORCID=

en-aut-name=MasudaMotoi
en-aut-sei=Masuda
en-aut-mei=Motoi
kn-aut-name=増田礎
kn-aut-sei=増田
kn-aut-mei=礎
aut-affil-num=7
ORCID=

en-aut-name=NakayamaEiji
en-aut-sei=Nakayama
en-aut-mei=Eiji
kn-aut-name=中山英治
kn-aut-sei=中山
kn-aut-mei=英治
aut-affil-num=8
ORCID=

en-aut-name=KurabayashiYuzuru
en-aut-sei=Kurabayashi
en-aut-mei=Yuzuru
kn-aut-name=倉林譲
kn-aut-sei=倉林
kn-aut-mei=譲
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=株式会社エイチ･エス･ピー技術開発部

affil-num=2
en-affil=
kn-affil=株式会社エイチ･エス･ピー技術開発部

affil-num=3
en-affil=
kn-affil=株式会社エイチ･エス･ピー技術開発部

affil-num=4
en-affil=
kn-affil=株式会社エイチ･エス･ピー技術開発部

affil-num=5
en-affil=
kn-affil=株式会社エイチ･エス･ピー技術開発部

affil-num=6
en-affil=
kn-affil=株式会社エイチ･エス･ピー技術開発部

affil-num=7
en-affil=
kn-affil=株式会社エイチ･エス･ピー技術開発部

affil-num=8
en-affil=
kn-affil=福田種鶏場株式会社

affil-num=9
en-affil=
kn-affil=岡山大学自然生命科学研究支援センター動物資源部門
END

start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=5
article-no=
start-page=493
end-page=494
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=1986
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Determination of Potassium in River Water by Solvent Extraction- Flow Injection Analysis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IwachidoTadashi
en-aut-sei=Iwachido
en-aut-mei=Tadashi
kn-aut-name=岩知道正
kn-aut-sei=岩知道
kn-aut-mei=正
aut-affil-num=1
ORCID=

en-aut-name=OnodaMinoru
en-aut-sei=Onoda
en-aut-mei=Minoru
kn-aut-name=小野田稔
kn-aut-sei=小野田
kn-aut-mei=稔
aut-affil-num=2
ORCID=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学
en-keyword=Potassium
kn-keyword=Potassium
en-keyword=4-[[4-(phenylamino)phenyl]azo]-2,5-dichlorobenzenesulfonic acid
kn-keyword=4-[[4-(phenylamino)phenyl]azo]-2,5-dichlorobenzenesulfonic acid
en-keyword=extraction
kn-keyword=extraction
en-keyword=flow injection analysis
kn-keyword=flow injection analysis
END

start-ver=1.4
cd-journal=joma
no-vol=35
cd-vols=
no-issue=4
article-no=
start-page=344
end-page=348
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19860405
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Spectrophotometric determination of boron by flow injection analysis
kn-title=フローインジェクション分析法によるホウ素の吸光光度定量
en-subtitle=
kn-subtitle=
en-abstract=Spectrophotometric determination of boron existing as boric acid in water was examined with H-resorcinol {1-(2, 4-dihydroxy-1-phenylazo)-8-hydroxynaphthalene-3, 6-disulfonic acid} by flow injection analysis. Carrier solution (deionized water) and reagent solution were propelled by double plunger pump (flow rate : 0.6 ml/min), and sample solution (320 μl) was injected into a carrier stream. The reagent solution was prepared by dissolving 0.096 g of H-resorcinol in 1 1 of ammonium acetate buffer solution (50 g/l, pH 5.5) containing 3.72 g of EDTA. The two streams were mixed in 16 m long Teflon tubing (0.5 mm i.d.), and the mixture was flowed through a flow cell (36 μl; 1.5 mm i.d.×20 mm), at which the absorbance of boron-H-resorcinol complex was detected (λ=510 nm). The linear relationship between the peak height and concentration of boron was obtained in the range of 0 to 1 ppm. The detection limit was 5 ppb (S/N=2). The sampling rate was 30 samples per hour. Generally ions co-existing in river and sea waters did not interfere with the determination of boron by adding EDTA solution.
kn-abstract=H-レゾルシノール{1-(2,4-ジヒドロキシ-1-フェニルアゾ)-8-ヒドロキシナフタレン-3,6-ジスルホン酸}とホウ酸との反応を利用したホウ素の吸光光度フローインジェクション分析について検討した.ダブルプランジャー型ポンプを用い,一方にキャリヤー液(イオン交換水)を流し,もう一方に反応試薬溶液(H-レゾルシノールとEDTAを含むpH5.5の酢酸アンモニウム緩衝液)を流し,キャリヤー液流中に試料水を注入した.キャリヤー液と反応試薬液は反応コイル中で混合した.錯体の生成を促進するために,反応コイルを恒温槽中(100℃)で加熱する.その後混合液はフローセル(36μl)に導かれ,ホウ素錯体の吸光度を測定した(波長510nm).ホウ酸と反応する試薬についてはH酸(1-アミノ-8-ヒドロキシナフタレン-3,6-ジスルホン酸)誘導体14種類について検討した結果,温レゾルシノールを用いることにした.河川水,海水中に普通存在する程度の金属イオン及び無機陰イオンは定量を妨害しない.0.1M程度のナトリウムイオン,カリウムイオンは負の誤差を与えるが,海水は20倍に希釈して測定するのでこれらイオンの妨害は問題とはならなかった.検量線は0～夏PP田の範囲で直線性を示し,検出限界は5ppb(S/N=2)であった.又ホウ素108ppbでの10回繰り返し実験の相対標準偏差は0.53%であった.毎分0.6mlで送液し試料注入量320μl,反応コイル0.5mm i.d.×16mとしたときの分析速度は1時間当たり約30試料である.
en-copyright=
kn-copyright=

en-aut-name=ToeiKyoji
en-aut-sei=Toei
en-aut-mei=Kyoji
kn-aut-name=桐栄恭二
kn-aut-sei=桐栄
kn-aut-mei=恭二
aut-affil-num=1
ORCID=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=2
ORCID=

en-aut-name=OshimaMitsuko
en-aut-sei=Oshima
en-aut-mei=Mitsuko
kn-aut-name=大島光子
kn-aut-sei=大島
kn-aut-mei=光子
aut-affil-num=3
ORCID=

en-aut-name=OnodaMinoru
en-aut-sei=Onoda
en-aut-mei=Minoru
kn-aut-name=小野田稔
kn-aut-sei=小野田
kn-aut-mei=稔
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=岡山大学
en-keyword=spectrophotometry of boron with H-resorcinol by flow injection analysis
kn-keyword=spectrophotometry of boron with H-resorcinol by flow injection analysis
en-keyword=water samples
kn-keyword=water samples
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=10
article-no=
start-page=1821
end-page=1837
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on vector of Umayado Disease in Kagawa-ken part Ⅱ Seasonal Occurrence of Tsutsugamushi
kn-title=香川県下における「馬宿病」の媒介体に関する研究 第二編 「馬宿病」流行地区における恙虫の季節的消長
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract="Umayado Disease" has happened in summer especially at east area of Kagawa-ken. I have studied about what kind of Tsutsugamushi will have increased and made peak at summer. Against this purpose, I have caught rats and collected the Tsutsugamushi living upon the rats twice a month regularly extending full 2 years up, and I have determined that a lot of Trombicula tosa has appeared and made the peak at summer usually. I think Trombicula tosa should be valuable agency to contaminate the Rickettsia orientalis at Kagawa-ken.
en-copyright=
kn-copyright=

en-aut-name=OnoYoshiaki
en-aut-sei=Ono
en-aut-mei=Yoshiaki
kn-aut-name=小野吉昭
kn-aut-sei=小野
kn-aut-mei=吉昭
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=9
article-no=
start-page=1517
end-page=1534
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19560930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=香川県下における「馬宿病」の媒介体に関する研究 第一篇 「馬宿病」の発生地方を中心に採集した恙虫の分類について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=I have studied on species of Trombicula developing at contaminated area by Rickettsia orientalis since 1953. So called "Umayado Disease" which proved severe signs usually has happened every year at summer especially at the east area of Kagawa-ken, and this disease was analysed by Dr. NOKIHARA by its serological intemes performed eagerly to prove the original nature of the disease, and has proved that so called "Umayado Disease" was nothing but "Tsutsugamushi Disease". This time, I have investigated the agencies comtaminating and spreading the Rickettsial agent, and have developed Trombicula which analysed 3 Genus and 10 species as follows, 1) Trombicula (Leptotrombidium) Kitasatoi FUKUZUMI et OBATA, 1950 2) Trombicula (Leptotrombidium) tosa SASA et KAWASHIMA, 1951 3) Trombicula (Leptotrombidium) pallida NAGAYO, MITAMURA et TAMIYA, 1919 4) Trombicula (Leptotrombidium) murotoensis SASA et KAWASHIMA, 1951 5) Trombicula (Leptotrombidium) kuroshio SASA et KAWASHIMA, 1951 6) Trombicula (Leptotrombidium) fuji KUWATA, BERGE et PHILIP, 1950 7) Trombicula (Leptotrombidium) miyajimai FUKUZUMI et OBATA, 1950 8) Trombicula (Miyatrombicula) kochiensis SASA, KAWASHIMA et EGASHIRA, 1952 9) Euschongastia alpina SASA et JAMESON, 1953 10) Gahrliepia saduski WAMERSLEY, 1952
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野吉昭
kn-aut-sei=小野
kn-aut-mei=吉昭
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=7
article-no=
start-page=743
end-page=751
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19560731
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Electronmicroscopy of the human brain tissue. Part Ⅲ.
kn-title=人脳組織の電子顕微鏡学的研究 第3篇 死後の自家融解性変化について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1) The main postmortal autolytic changes were melting or agglutination of the fine granules, swelling and contraction of the cells. 2) The specimen for electron microscope should be fixed early as possible. 3) The fine structures were preserved relatively well within 2 hours after death. Therefore the specimens obtained within 2 postmortal hours could be used satisfactorily for the electron microscope. If unavoidable, the specimens obtained until 5 postmortal hours could be used, but the investigation of the fine changes might be difficult. 5) The specimens over 5 hours could not be used for electron microscope.
en-copyright=
kn-copyright=

en-aut-name=OnoMasakazu
en-aut-sei=Ono
en-aut-mei=Masakazu
kn-aut-name=小野正員
kn-aut-sei=小野
kn-aut-mei=正員
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=7
article-no=
start-page=733
end-page=741
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19560731
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Electronmicroscopy of the human brain tissue. Part Ⅱ
kn-title=人脳組織の電子顕微鏡学的研究 第2編 各種固定液による像の変化につて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1) For the purpose of preserving the fine structure of cells, the osmic acid was the best for fixation and then in the order of formalin, Zenker's formalin solution, Bouin's solution, Carnoy's solution, alcohol and aceton. 2) By formalin fixation the ground substance of the nuclei was preserved best. 3) By alcohol fixation the cells were destroyed most severely and tended to make dense and coarse precipitations. 4) Zenker's formalin solution and Bouin's solution gave almost similar figures of fixation, but the former preserved better the fine structures. 5) By Carnoy's solution the fine structures were slightly better preserved than by alcohol. 6) After aceton fixation no good figures were obtained for electronmicrosopy. 7) The fixing solutions except osmic acid were not satisfatory enough by single use, but when they were combined with osmic acid, they became useful to clarify the figures.
en-copyright=
kn-copyright=

en-aut-name=OnoMasakazu
en-aut-sei=Ono
en-aut-mei=Masakazu
kn-aut-name=小野正員
kn-aut-sei=小野
kn-aut-mei=正員
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=7
article-no=
start-page=713
end-page=731
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19560731
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Electronmicroscopy of the human brain tissue. Part Ⅰ
kn-title=人脳組織の電子顕微鏡学的研究 第1編 脳組織の基本構造について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Ultrathin sections of human brain were made and investiggated by electron microscope; The fine structures of nerve cells, glia cells, nerve and glia fibres and Nissl's grey were eclearly observed. These results were obtained from single section method, but there are many points, which are not yet cleared, the series section method seems to be necessary for the purpose of making them clear.
en-copyright=
kn-copyright=

en-aut-name=OnoMasakazu
en-aut-sei=Ono
en-aut-mei=Masakazu
kn-aut-name=小野正員
kn-aut-sei=小野
kn-aut-mei=正員
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=5
article-no=
start-page=357
end-page=360
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19560531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=トキソプラスマ症の研究 第1報 岡山近郊に於けるトキソプラスミン皮内反応陽性率
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=難波益之
kn-aut-sei=難波
kn-aut-mei=益之
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=大月三郎
kn-aut-sei=大月
kn-aut-mei=三郎
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小川哲郎
kn-aut-sei=小川
kn-aut-mei=哲郎
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野昌也
kn-aut-sei=小野
kn-aut-mei=昌也
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=那須弘之
kn-aut-sei=那須
kn-aut-mei=弘之
aut-affil-num=5
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=更井啓介
kn-aut-sei=更井
kn-aut-mei=啓介
aut-affil-num=6
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=河田三郎
kn-aut-sei=河田
kn-aut-mei=三郎
aut-affil-num=7
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=上永広済
kn-aut-sei=上永
kn-aut-mei=広済
aut-affil-num=8
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=湯之上茂
kn-aut-sei=湯之上
kn-aut-mei=茂
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部神経精神医学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部神経精神医学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部神経精神医学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部神経精神医学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部神経精神医学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部神経精神医学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部神経精神医学教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=5
article-no=
start-page=211
end-page=218
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19560531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The statistical observations of the out-patients and in-patients during five years since the opening of the Department of Oral Surgery, Okayama University Medical School
kn-title=岡山大学医学部歯科学教室開講5ケ年間に於ける外来患者並びに入院患者の統計的観察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The statistic observations were made about the inpatients and out-patients of the department of oral surgery, okayama university medical school during full five years from July in 1950 to June in 1955. The out-patients were classified into those of inflammation (pulpitis and gingivitis excepted), of caries (which was divided into what needed canal treatment and what was not so serious), of pyorrhea alveolaris, of gingivitis, of tumour, and of other diseases, and then each disease group was observed according to the difference year, season, tooth, sex, age, and occupation. Thereby, comparatively remarkable, interesting, statistical, numeral values were not only obtained concerning to each disease, but also the characteristics of the department of oral surgery of the attached hospitals of our government universities were apparently recognized here also. As the total number of the in-patients was only 237, the detailed statistical report being reserved, they were observed only according to the difference of year and disease. Thereby, inflammation and tumour were so many that they occupied about 80% of the number of all the in-patients.
en-copyright=
kn-copyright=

en-aut-name=FujiokaYukio
en-aut-sei=Fujioka
en-aut-mei=Yukio
kn-aut-name=藤岡幸雄
kn-aut-sei=藤岡
kn-aut-mei=幸雄
aut-affil-num=1
ORCID=

en-aut-name=OnoHajime
en-aut-sei=Ono
en-aut-mei=Hajime
kn-aut-name=小野一
kn-aut-sei=小野
kn-aut-mei=一
aut-affil-num=2
ORCID=

en-aut-name=NishijimaKatsumi
en-aut-sei=Nishijima
en-aut-mei=Katsumi
kn-aut-name=西嶋克巳
kn-aut-sei=西嶋
kn-aut-mei=克巳
aut-affil-num=3
ORCID=

en-aut-name=KagawaGaiji
en-aut-sei=Kagawa
en-aut-mei=Gaiji
kn-aut-name=香川凱二
kn-aut-sei=香川
kn-aut-mei=凱二
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部歯科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部歯科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部歯科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部歯科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=4-2
article-no=
start-page=1781
end-page=1784
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19590405
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Oxidation of G-6-P, 6-P-G and R-5-P in the Epileptic Cerebral Cortex
kn-title=眞正癲癇大脳皮質によるGlucose-6-phosphate, 6-PhosphogulconateおよびRibose-5-phosphateの酸化について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The oxidations of G-6-P, 6-P-G and R-5-P in the human epileptic cerebral cortex were measured by Warburg's manometer and compared with those of non-epileptic cerebral cortex. The results were as follows: 1) The oxidation of G-6-P, 6-P-G and R-5-P in epileptic cerebral cortex, showed stronger tendency to be controlled than that of the non-epileptic. 2) The oxidation of G-6-P and 6-P-G were more accerelated by the addition of TPN in both cases, and then the difference of oxidation in the each cases of epileptic and non-epileptic cerebral cortex became less. 3) From the facts mentioned above, it is considered that the shunt pathway of glucose metabolism, i. e. Warburg-Dickens scheme, exists in the brain also as in the liver.
en-copyright=
kn-copyright=

en-aut-name=OnodaOsamu
en-aut-sei=Onoda
en-aut-mei=Osamu
kn-aut-name=小野田収
kn-aut-sei=小野田
kn-aut-mei=収
aut-affil-num=1
ORCID=

en-aut-name=AsahinaMasaru
en-aut-sei=Asahina
en-aut-mei=Masaru
kn-aut-name=朝比奈勝
kn-aut-sei=朝比奈
kn-aut-mei=勝
aut-affil-num=2
ORCID=

en-aut-name=NishiharaYohichi
en-aut-sei=Nishihara
en-aut-mei=Yohichi
kn-aut-name=西原庸一
kn-aut-sei=西原
kn-aut-mei=庸一
aut-affil-num=3
ORCID=

en-aut-name=TanakaYoshinori
en-aut-sei=Tanaka
en-aut-mei=Yoshinori
kn-aut-name=田中美登
kn-aut-sei=田中
kn-aut-mei=美登
aut-affil-num=4
ORCID=

en-aut-name=MoriAkitane
en-aut-sei=Mori
en-aut-mei=Akitane
kn-aut-name=森昭胤
kn-aut-sei=森
kn-aut-mei=昭胤
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一外科教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一外科教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一外科教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=11
article-no=
start-page=4025
end-page=4036
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19581130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Bone-Marrow Tissue Culture, the Simple Method of oue Design Part 3. The Bone Marrow of Normal Rabbits and of the Rabbits with Experimental Anemia
kn-title=簡易骨髄組織培養法に関する研究 第三編 健康家兎及び実験貧血家兎骨髄に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By the simple method of bone-marrow tissue culture previously mentioned, the anther performed the bone-marrow tissue culture of rabbits, and arrived at the following conclusions: 1. In the bone-marrow tissue culture of rabbits just as in the case of human bone marrow the addition of vitamin B(12) at the concentration of 100 r/cc. is most suitable. In the case of bone-marrow tissue culture of normal rabbits the rate of tissue growth and the wandering velocrty of pseeudoeosinophils resemble quite clososely to those of the conventional method of culture. 2. The duration of arrest-time of all cells is 48 hours, being shorter than that of the conventional method of culture, and moreover, the culture stages can not be divided info throce stages of the initial, intermediate and terminal stages, but it moves from the initial stage directly to the terminal stage. However, this method of tirsue culture is suffisently appliccable for the observation of bone-marrow functions. 3. In the bone marrow tissue culture of acute anemic rabbits 5 days after blood-deplation, the tissue growth rate and the wandering velocity of pseudoeosinophils are higher than those of normal rabbits; and moreover, these findings resemble quite closely to those by the conventional method of bone-marrow tissue culture. From these findings it has been clarified that by using this simple method even in the case of rabbit bone marrow the same as in the case of human bone marrow it is possib1e to learn a certain aspect of the bone marrow function similarly as by the conventional method of culture.
en-copyright=
kn-copyright=

en-aut-name=OnoYasuzo
en-aut-sei=Ono
en-aut-mei=Yasuzo
kn-aut-name=小野安三
kn-aut-sei=小野
kn-aut-mei=安三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=11
article-no=
start-page=4011
end-page=4023
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19581130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Bone-Marrow Tissue Culture, the Simple Method of one Design Part 2. The Bone Marrow of Patients with Various Blood Diseases
kn-title=簡易骨髄組織培養法に関する研究 第二編 各種血液疾患々者骨髄に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By performing a series of bone-marrow tissue culture of patients with various blood diseases by simple method the author studied the tissue growht and the wandering velocity of mature neutrophils, and arrived at the following conclusions: 1. In the case of chronic myelogenous leukemia the tissue growth is excellent, but the wandering velocity of mature neutrophils is somewhat decreased. In the cases of acute myelogenous leukemia monocytic leukemia the rate of relative growht is somewhat lower than in the case of normal persons: and the wandering velocity of mature neutrophils shows a markedly low value. The boundary of the growth zone is sharply demarcated, and the cell density index is high, presenting the growth pattern chareteristic to leukemia. 2. In the case of hypoplastic anemia the tissue growth is extremely poor; and the wandering velocity of mature neutrophils is markedly low, showing an increase of fat cells in the explant. 3. In the case of Banti's disease the tissue growth is rather poor, and the wandering velocity of mature meutrophils is low. 4. In the case of essential hypochromic anemia both the tissue growth rate and the wandering velocity of mature neutrophils are identical with those of normal persons. 5. In the case of agranulocytosis the tissue growth is extremely poor, and showing no increase of fat cells in the explant, the treatment with ACTH, however, improves the bone marrow function strikingly. 6. In the case of pernicious anemia the wandering velociyt of mature neutrophils is accelerted by the presence of vitamin B(12) in the medium. These findings by this method of culture coincide almost exactly with those by the conventional method, and it is believed that this method can be widely used in clinics due to its simplicity manipulation.
en-copyright=
kn-copyright=

en-aut-name=OnoYasuzo
en-aut-sei=Ono
en-aut-mei=Yasuzo
kn-aut-name=小野安三
kn-aut-sei=小野
kn-aut-mei=安三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=11
article-no=
start-page=4003
end-page=4010
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19581130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studdies on the Bone-Marrow Tissue Culture, the Simple Method of our Design Part 1. The Methodology and the Bone Marrow of Healthy Persons
kn-title=簡易骨髄組織培養法に関する研究 第一編 方法論並びに健康人骨髄に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Although several noteworthy data have been obtained by clinical application of bonemarrow tissue culture, in view of the complexity of its procedures we have devised a simple method of bone-marrow tissue culture modified from the cover-slip method for the purpose of a still wider clincal application. By observing the bone marrow of the sternum of healthy persons by means of this method, the following results were obtained: 1. The medium was consisted of a drop each of normal human serum and vitamin B(12) solution placed on a tissue culture plate of our own device, and the best results were obtained by the vitamin B(12) solution (containing 100 r/cc) to be added to the serum; and the most suitable space-distance between the surface of the slideglass and the coverglass was in the range of 150-200 μ. 2. In the determination of the relative growth rate, cell-density index and the wandering velocity of mature neutrophils in the bonemarrow tissue culture of the sternum of healthy persons, within 24 hours of the culture the results obtained resemble quite closely to those obtained by the conventional method of tissue culture, proving that this method is sufficiently worthy of clinical application even though the shortening in the duration of arresttime in all cells can be observed.
en-copyright=
kn-copyright=

en-aut-name=OnoYasuzo
en-aut-sei=Ono
en-aut-mei=Yasuzo
kn-aut-name=小野安三
kn-aut-sei=小野
kn-aut-mei=安三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=7
article-no=
start-page=2547
end-page=2552
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580731
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Comparative Study on the Action of Aureomycin and Terramycin
kn-title=微生物に対するオーレオマイシンとテラマイシンの作用の比較
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Both of aureomycin and terramycin belong to the tetracycline, and their action has been considered to be nearly the same. The authors made a comparative study on the action of aureomycin and terramycin and obtained the following results: 1) The respiration of Escherichia coli in the presence of glucose, pyruvate, aspartate and glutamate is markedly inhibited by both of aureomycin and terramycin. The respiration inhibitory action of aureomycin is quantitatively about 3 times higher than that of terramycin. 2) The respiration of Micrococcus pyogenes var. aureus (Terashima) in the presence of glutamate, alanine, pyruvate and lactate is inhibited by both of aureomycin and terramycin. As for the respiration inhibitory action, aureomycin is quantitatively about 3 times stronger than terramycin. 3) The respiration of M. pyogenes var. sureus (Terashima) in the presence of glucose is not inhibited by aureomycin or terramycin, but is rather accelerated by these, particularly by terramycin. 4) As for the growth inhibitory action, aureomycin is somewnat stronger than terramycin.
en-copyright=
kn-copyright=

en-aut-name=YabeYoshiro
en-aut-sei=Yabe
en-aut-mei=Yoshiro
kn-aut-name=矢部芳郎
kn-aut-sei=矢部
kn-aut-mei=芳郎
aut-affil-num=1
ORCID=

en-aut-name=NakayamaGoro
en-aut-sei=Nakayama
en-aut-mei=Goro
kn-aut-name=中山五郎
kn-aut-sei=中山
kn-aut-mei=五郎
aut-affil-num=2
ORCID=

en-aut-name=HayashiSei
en-aut-sei=Hayashi
en-aut-mei=Sei
kn-aut-name=林生
kn-aut-sei=林
kn-aut-mei=生
aut-affil-num=3
ORCID=

en-aut-name=HashimotoRyohei
en-aut-sei=Hashimoto
en-aut-mei=Ryohei
kn-aut-name=橋本良平
kn-aut-sei=橋本
kn-aut-mei=良平
aut-affil-num=4
ORCID=

en-aut-name=OnoShigetada
en-aut-sei=Ono
en-aut-mei=Shigetada
kn-aut-name=小野繁忠
kn-aut-sei=小野
kn-aut-mei=繁忠
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部微生物学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部微生物学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部微生物学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4-6
article-no=
start-page=387
end-page=398
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Stndies on the Pneumoconiosis of Electric Welders
kn-title=電気熔接工のじん肺について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Sadatoshi, one of the authors, had reported previously that he had found 26% of electric welders at a certain heavy industrial plant suffered from pneumoconiosis by roentgenological examination. In this time investigation was done upon 78 electric welders carrying pneumoconiosis without pulmonary tuberculosis and the result was as follows: 1) Chest X-ray findings approved granulated type. No fibrosis, tendency of confluence, emphysema and eggshell calcification. Changes in hilus could not be found at the begining. 2) No visible changes in blood findings. Except, as the type advanced, a tendency of a slight decrease in neutrophil leukocytes and increase in lymphocytes could be seen. 3) No remarkable changes admitted in lung vital capacity and maximum ventulating volume. Expiratory impediment appeared in the third type. 4) Though welding dust contains SiO(2), welder's pneumoconiosis is innocent compared with silicosis. It also seems a little different from siderosis and so is suitable to classify it as "welder's Pneumoconiosis". 5) Occupational career should be cared when taking routine X-rayphotographs.
en-copyright=
kn-copyright=

en-aut-name=SadatoshiKurashi
en-aut-sei=Sadatoshi
en-aut-mei=Kurashi
kn-aut-name=貞利庫司
kn-aut-sei=貞利
kn-aut-mei=庫司
aut-affil-num=1
ORCID=

en-aut-name=AoyamaHideyasu
en-aut-sei=Aoyama
en-aut-mei=Hideyasu
kn-aut-name=青山英康
kn-aut-sei=青山
kn-aut-mei=英康
aut-affil-num=2
ORCID=

en-aut-name=ItamiYoshiaki
en-aut-sei=Itami
en-aut-mei=Yoshiaki
kn-aut-name=伊丹仁朗
kn-aut-sei=伊丹
kn-aut-mei=仁朗
aut-affil-num=3
ORCID=

en-aut-name=OnoMinoru
en-aut-sei=Ono
en-aut-mei=Minoru
kn-aut-name=大野稔
kn-aut-sei=大野
kn-aut-mei=稔
aut-affil-num=4
ORCID=

en-aut-name=OhnoKimiyoshi
en-aut-sei=Ohno
en-aut-mei=Kimiyoshi
kn-aut-name=小野公義
kn-aut-sei=小野
kn-aut-mei=公義
aut-affil-num=5
ORCID=

en-aut-name=OharaYasuro
en-aut-sei=Ohara
en-aut-mei=Yasuro
kn-aut-name=尾原安郎
kn-aut-sei=尾原
kn-aut-mei=安郎
aut-affil-num=6
ORCID=

en-aut-name=KatoShozi
en-aut-sei=Kato
en-aut-mei=Shozi
kn-aut-name=加藤尚司
kn-aut-sei=加藤
kn-aut-mei=尚司
aut-affil-num=7
ORCID=

en-aut-name=KanaiYoshiaki
en-aut-sei=Kanai
en-aut-mei=Yoshiaki
kn-aut-name=金井義明
kn-aut-sei=金井
kn-aut-mei=義明
aut-affil-num=8
ORCID=

en-aut-name=MitaniYasuo
en-aut-sei=Mitani
en-aut-mei=Yasuo
kn-aut-name=三谷恭夫
kn-aut-sei=三谷
kn-aut-mei=恭夫
aut-affil-num=9
ORCID=

en-aut-name=MotoiMakoto
en-aut-sei=Motoi
en-aut-mei=Makoto
kn-aut-name=元井信
kn-aut-sei=元井
kn-aut-mei=信
aut-affil-num=10
ORCID=

en-aut-name=MoriTakashi
en-aut-sei=Mori
en-aut-mei=Takashi
kn-aut-name=森巍
kn-aut-sei=森
kn-aut-mei=巍
aut-affil-num=11
ORCID=

affil-num=1
en-affil=
kn-affil=玉野三井綜合病院

affil-num=2
en-affil=
kn-affil=岡山大学医学部衛生学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部

affil-num=4
en-affil=
kn-affil=岡山大学医学部

affil-num=5
en-affil=
kn-affil=岡山大学医学部

affil-num=6
en-affil=
kn-affil=岡山大学医学部

affil-num=7
en-affil=
kn-affil=岡山大学医学部

affil-num=8
en-affil=
kn-affil=岡山大学医学部

affil-num=9
en-affil=
kn-affil=岡山大学医学部

affil-num=10
en-affil=
kn-affil=岡山大学医学部

affil-num=11
en-affil=
kn-affil=岡山大学医学部
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=4
article-no=
start-page=1243
end-page=1253
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Fibrinolysis Following Massive Transfusion of Preserved Blood, and on the Treatment Part Ⅱ. Experimental Studies on the Treatment of Fibrinolysis Following Massive transfusion of Preserved blood
kn-title=保存血大量輪血に伴う出血傾向に対する線維素溶解現象の発現とその対策 第2編 保存血大量輸血時の線維溶解現象発現に対する対策
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Therapeutic and prophylactic measures against a fibrinolysis following massive transfusion of preserved blood was studied, and following results were obtained. 1. Administration of ε-aminocaplonic acid, ACTH, and cortisone prevented a fibrinolysis following massive transfusion of preserved blood. 2. These therapeutics, especially, showed a marked preventive effect when they were applied together at early stage. 3. At the same time in the cases administed together with thromboplastin and adrenochrome preparations of every kinds as well as fresh blood, fibrinolysis was not completely prevented, but those were expected to inhibit other disturbance in coagulation mechanism accompanied with the above phenomenon.
en-copyright=
kn-copyright=

en-aut-name=OnoMasayosi
en-aut-sei=Ono
en-aut-mei=Masayosi
kn-aut-name=小野昌美
kn-aut-sei=小野
kn-aut-mei=昌美
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=4
article-no=
start-page=1227
end-page=1241
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Fibrinolysis Following Massive Transfusion of Preserved Blood, and on the Treatment Part 1. Experimental and clinical studies on the mechanism of fibrinolysis
kn-title=保存血大量輸血に伴う出血傾向に対する線維素溶解現象の発現とその対策 第1編 保存血大量輸血時の線維素溶解現象発現機序に対する検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The mechanism of fibrinolysis following massive transfusion of preserved blood was investigated, clinically and experimentally. Results obtained were as follows: 1. Fibrinolytic activity was not seen in the preserved blood, and the fibrinolysis observed in the transfusion of preserved blood was derived from preserved blood itself which acted upon as a stress, but it was slight in the degree. On the other hand, the fibrinolysis was relatively remarkable in the cases undertaking sugical procedures, especially a pulmonary operation, and etc. However, it was not considered that either one of above cases would become to develop a hemorrhagic tendency. 2. Fibrinogen level did not show a remarkable change with a massive transfusion of preserved blood, but was decreased in the cases operated upon the organs being high in the thromboplastin level and became a cause of a hemorrhagic tendency. 3. A hemorrhagic tendency was not always observed even in the cases showing highly positive fibrinolysis, but it was thought to be cased by the defects in platelet, vascular and coagulation factors of many kinds, in conjuction with the changes in general and local conditions of patients, and with surgical procedures. The fibrinolysin, however, promoted the development of hemorrhagic tendency following the disturbances in vascular and various kinds of coagulation factors.
en-copyright=
kn-copyright=

en-aut-name=OnoMasayosi
en-aut-sei=Ono
en-aut-mei=Masayosi
kn-aut-name=小野晶美
kn-aut-sei=小野
kn-aut-mei=晶美
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=811
end-page=820
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Serum Hepatitis Resulted from Blood Transfusion
kn-title=輸血による血清肝炎について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In recent years there have been many cases, with increasing frequency, of serum hepatitis resulted from blood transfusion. The purpose of this study was to investigate the incidence, clinical feature, prognosis and prophylaxis of serum hepatitis followed by blood transfusion. The results obtained were as follows; 1) Incidence of serum hepatitis among the patients who had blood transfusion at local institutions in Okayama City was 3.3% in 1957 and 4.7% in 1958, on the other hand, at Okayama University Hospital in 1958 it was 5.0% in the First Surgical Division, 5.4% the Second Surgery and 5.2% OBGYN respectively. The patients with serum hepatitis had
received the amount 2,600 to 1,120 cc of blood, whereas 810 to 1,120 cc in the cases who never developed serum hepatitis after blood transfusion. 2) Mean incubation period was 72.8 days ranging 19 to 180 days calculated from the date of last blood transfusion. Prodremal stage varied from 1 to 20 days, average 6.1 days, icteric stage 7 to 15 days, average 35.8 days, and convalescent stage 7 to 200 days, average 30.0 days. 3) Characteristic initial symptoms were anorexia, malaise and jaundice by which fairly number of the cases noticed the onset of the disease. Few had febrile course but low grade in most of the cases. 4) Laboratory data were obtained from the 20 cases of serum hepatitis admitted to our First Mebical Division. Serum bilirubin showed the maximum level on the 10 th day, average 13.0 mg% . No significant changes were noted in peripheral blood picture but for a slight initial monocytosis. SGO-T and SGP-T presented a elevation earlier than that of serum bilirubin, maximum on or about the 5 th day and then decreased abruptly. Serum colloidal liver function tests; in initial stage, positive Takata's reaction in 51.%, positive CCF 46% and TTT 58% were noted, but even after 100 th day Takata's reaction was positive in 25% of the cases. 5) Follow-up studies were made on 49 serum hepatitis cases discharged from our hospital with complete recovery. 69% of these had subjective symptems in some sort or another. Enlargement of the liver was noted in 20% of the cases. 33 cases were studied with special reference to liver function tests and liver biopsy. It was revealed that 43% of the cases still had impairment of liver function and that by means of liver biopsy, postnecrotic cirrhosis was found 9.1% of the cases. Therefore, the prognosis of serum hepatitis of this type was considered to be grave. 6) For the purpose of prophylaxis, 300 to 600 mg of gamma globulin was simultaneously administered on blood transfusion in 38 cases. Inspite of this, 4 cases suffered from serum hepatitis later on, and no definite prophylactic effect of gamma globulin was noted.
en-copyright=
kn-copyright=

en-aut-name=KosakaKiyowo
en-aut-sei=Kosaka
en-aut-mei=Kiyowo
kn-aut-name=小坂淳夫
kn-aut-sei=小坂
kn-aut-mei=淳夫
aut-affil-num=1
ORCID=

en-aut-name=NagashimaHideo
en-aut-sei=Nagashima
en-aut-mei=Hideo
kn-aut-name=長島秀夫
kn-aut-sei=長島
kn-aut-mei=秀夫
aut-affil-num=2
ORCID=

en-aut-name=YamabukiTakahiro
en-aut-sei=Yamabuki
en-aut-mei=Takahiro
kn-aut-name=山吹隆寛
kn-aut-sei=山吹
kn-aut-mei=隆寛
aut-affil-num=3
ORCID=

en-aut-name=YamamotoShigeru
en-aut-sei=Yamamoto
en-aut-mei=Shigeru
kn-aut-name=山本繁
kn-aut-sei=山本
kn-aut-mei=繁
aut-affil-num=4
ORCID=

en-aut-name=UedaYutaka
en-aut-sei=Ueda
en-aut-mei=Yutaka
kn-aut-name=植田胖
kn-aut-sei=植田
kn-aut-mei=胖
aut-affil-num=5
ORCID=

en-aut-name=EndoKenichi
en-aut-sei=Endo
en-aut-mei=Kenichi
kn-aut-name=遠藤憲一
kn-aut-sei=遠藤
kn-aut-mei=憲一
aut-affil-num=6
ORCID=

en-aut-name=KusudoHiroshi
en-aut-sei=Kusudo
en-aut-mei=Hiroshi
kn-aut-name=楠戸宏
kn-aut-sei=楠戸
kn-aut-mei=宏
aut-affil-num=7
ORCID=

en-aut-name=OnoNobuhiro
en-aut-sei=Ono
en-aut-mei=Nobuhiro
kn-aut-name=小野延宏
kn-aut-sei=小野
kn-aut-mei=延宏
aut-affil-num=8
ORCID=

en-aut-name=KobashiNobuo
en-aut-sei=Kobashi
en-aut-mei=Nobuo
kn-aut-name=小橋暢夫
kn-aut-sei=小橋
kn-aut-mei=暢夫
aut-affil-num=9
ORCID=

en-aut-name=AsadaKiyotaka
en-aut-sei=Asada
en-aut-mei=Kiyotaka
kn-aut-name=浅田清隆
kn-aut-sei=浅田
kn-aut-mei=清隆
aut-affil-num=10
ORCID=

en-aut-name=KajiMasayoshi
en-aut-sei=Kaji
en-aut-mei=Masayoshi
kn-aut-name=加地正義
kn-aut-sei=加地
kn-aut-mei=正義
aut-affil-num=11
ORCID=

en-aut-name=KitagawaToshinori
en-aut-sei=Kitagawa
en-aut-mei=Toshinori
kn-aut-name=北川紀典
kn-aut-sei=北川
kn-aut-mei=紀典
aut-affil-num=12
ORCID=

en-aut-name=ShinoharaToshio
en-aut-sei=Shinohara
en-aut-mei=Toshio
kn-aut-name=篠原敏夫
kn-aut-sei=篠原
kn-aut-mei=敏夫
aut-affil-num=13
ORCID=

en-aut-name=TakakiTadateru
en-aut-sei=Takaki
en-aut-mei=Tadateru
kn-aut-name=高木直輝
kn-aut-sei=高木
kn-aut-mei=直輝
aut-affil-num=14
ORCID=

en-aut-name=NishidaTakeshi
en-aut-sei=Nishida
en-aut-mei=Takeshi
kn-aut-name=西田彪
kn-aut-sei=西田
kn-aut-mei=彪
aut-affil-num=15
ORCID=

en-aut-name=NagoshiKazuma
en-aut-sei=Nagoshi
en-aut-mei=Kazuma
kn-aut-name=名越一馬
kn-aut-sei=名越
kn-aut-mei=一馬
aut-affil-num=16
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=10
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=11
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=12
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=13
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=14
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=15
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=16
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=2
article-no=
start-page=515
end-page=520
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Transaminase of Brain (Ⅱ) Effects of Psychotropic and Neurotropic Drugs on the Transaminase Activities
kn-title=脳のトランスアミナーゼ 第2編 各種向精神・神経薬のダイコクネズミ脳組織トランスアミナーゼ活性に及ぼす影響
en-subtitle=
kn-subtitle=
en-abstract=Effects of 18 psychotropic and 3 neurotropic drugs were measured by the author on the glutamic-aspartic transaminase (GAT) activities in the rat brain homogenates. 1. Chlorpromazine, chlopromazine sulfoxide, acetylpromazine, levomepromazine, mepazine and perphenazine inhibited GAT, while prochlorperazine showed no effect. Both of diethazine and promethazine did not effect on GAT. 2. Pipradrol and dimethylaminoethanol activated GAT, while methylphenidate showed no effect. 3. Azacyclonol, amobarbital, phenobarbital, methyprylon, glutethimide and primidone were inhibitory in acion on GAT. 4. LSD-25 inhibited to GAT and bemegride did not effect on. 5. In the effect on GAT, similarities of imipramine to the phenothiazine derived depressants, or differences of diethazine and promethazine from other phenothiazine derivatives seemed to be causad due to the resemble or different distance between two nitrogen atoms.
kn-abstract=ダイコクネズミ脳homogenateを用い，グルタミン酸-アスパラギン酸トランスアミナーゼ（GAT）活性に及ぼす18種の向精神薬，および3種の向神経薬の影響を測定した. 1. フエノチアジン系向精神薬は， Prochlorperazineを除く他の6種はいずれもGAT阻害を示し，阻害作用はChlorpromazineに最も強かつた. Chlorpromazine S-oxideはChlorpromazineに比してGAT阻害作用は著しく弱い. 2種のフエノチアジン系向神経薬はGAT活性に影響をみなかつた. 2. AzacyclonolはGAT阻害を示し， LSD-25は高濃度で阻害を示したが低濃度では影響を与えなかつた. 3. 中枢刺戟剤4種のうち， PipradrolとDMAEは促進， Methylphenidateは影響なく， Tofranilは阻害を示した. 4. バルビツール酸系睡眠剤AmobarbitalとPhenobarbital，非バルビツール酸系睡眠剤MethyprylonとGlutethimideは，すべて阻害を示した.しかるにバルビツール酸拮抗剤BemegrideはGATに無影響であつた.抗てんかん剤Primidoneは阻害を示した. 5. 実験に用いた中枢抑制剤13種のうち12種が阻害を示した. 6. GATに及ぼす作用において， ImipramineとChlorpromazineの類似， DiethazineやPromethazineとChlorpromazineとの差異を，化学構造における2個のN原子間の距離の一致と相異に対応すると考えた.
en-copyright=
kn-copyright=

en-aut-name=OnoMasaya
en-aut-sei=Ono
en-aut-mei=Masaya
kn-aut-name=小野昌也
kn-aut-sei=小野
kn-aut-mei=昌也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=2
article-no=
start-page=507
end-page=513
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Transaminase of Brain (I) Transaminase Activities of the Monkey and Human Brain
kn-title=脳のトランスアミナーゼ 第1編 タイワンザル脳およびヒト脳におけるトランスアミナーゼ活性について
en-subtitle=
kn-subtitle=
en-abstract=The author measured the transaminase activities of eighteen amino acids with α-keto-glutarate in a Pithecus monkey brain and in two human brains, one obtained from a man died from accident and another from a woman died of senile psychosis due to brain atrophy. 1. In the monkey brain, alanine and valine showed low activities in the cerebral cortex in comparison with other parts but γ-amino-β-hydroxybutyric acid showed a low activity. 2. In normal human brain, lower activities of valine, leucine and three ω-amino acids were showed in the cerebral cortex, which were different from the monkey and lower vertebrates. 3. The markedly atrophic cerebral cortex was more similar to the lower vertebrates than to the normal human brain in high activities of alanine, leucine, valine and γ-amino-β-hydroxybutyric acid. But an increase of activities of histidine, proline and ornithine was not similar to both of normal human and animal brain. These high activities of histidine and praline correspond unlikely to the transamination only.
kn-abstract=タイワンザル脳，事故死ヒト脳の大脳皮質，大脳白質および小脳皮質，さらに高度の脳萎縮を伴い老人性痴呆にて死亡したヒト脳の大脳皮質を用い， 11種のα-アミノ酸， 3種のω-アミノ酸， 3種のヂアミノ酸，システイン酸，タウリンについて，組織のトランスアミナーゼ活性を測定した. 1. タイワンザル脳では，大脳皮質においてアラニンとバリンの活性が他部より低く，γ-アミノ酪酸とγ-アミノ-β-オキシ酪酸が高い. 2. 健常人脳では，アスパラギン酸，セリンが大脳皮質に，ヒスチジン，ロイシン，バリンが小脳皮質にて他部より高く，アラニン，フエニールアラニン，システイン酸は大脳白質において低い活性を示した. 3. タイワンザルおよび健常ヒト脳の大脳皮質では，いずれもアスパラギン酸，グリシン，フエニールアラニン，オルニチン，システイン酸の高い活性，およびアラニンの低い活性の点で他の下等動物脳と異なる. 4. 健常ヒト大脳皮質は，バリン，ロイシンおよび3種のω-アミノ酸の低い活性を以つてサルおよび下等動物と異なる. 5. 萎縮したヒト大脳皮質は，アラニン，ロイシン，バリン，γ-アミノ-β-オキシ酪酸の活性が健常ヒト大脳皮質より高く，むしろ下等動物のそれに近い.ヒスチジン，プロリン，オルニチンのグルタミン酸生成の著しい増加は健常ヒト脳および下等動物脳のいずれとも異なるが，ヒスチジンとプロリンはトランスアミナーゼ活性増加のみによるものかどうか疑わしい.
en-copyright=
kn-copyright=

en-aut-name=OnoMasaya
en-aut-sei=Ono
en-aut-mei=Masaya
kn-aut-name=小野昌也
kn-aut-sei=小野
kn-aut-mei=昌也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=1
article-no=
start-page=301
end-page=308
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19591230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immunological Studies on Epidemic Hapatitis Part Ⅲ Studies on the Clinical Symptoms of Epidemic Hepatits Accompained by the Epidemic Transition
kn-title=流行性肝炎の疫学的研究 第3編 流行の推移に伴う流行性肝炎の臨床症状に関する検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The clinical symptoms of epidemic hepatitis at the Onoda, and Toyoda districts of Kumayama-cho, Akayuwa-gun in Okayama prefecture were mostly the typical form and violent form until February 1953 from the beginning of the prevalence in 1952, and the symptoms became gradually mild until the end of 1954 from the spring of 1953 at which time the prevalence became prolonged and the increase of the abortive form and mild form was observed. And it was certified that the prolongation of the prevalence brought remarkable changes on the clinical picture.
en-copyright=
kn-copyright=

en-aut-name=OnoNobuhiro
en-aut-sei=Ono
en-aut-mei=Nobuhiro
kn-aut-name=小野延宏
kn-aut-sei=小野
kn-aut-mei=延宏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=1
article-no=
start-page=287
end-page=300
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19591230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immunological Studies on Epidemic Hepatitis Part Ⅱ Studies on the Epidemic Type of Epidemic Hepatitis
kn-title=流行性肝炎の疫学的研究 第2編 流行性肝炎の流行形式について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The prevalence of epidemic hepatitis at Kumayama-cho, Akayuwa-gun in Okayama prefecture was fully observed for 3 years and the epidemic type was studied. And the ressults were as follows. 1. Studying the prevalence on the 3 parts of the district dividing by the unit of old village distribution, the prevalence progressed slowly, and it was mostly sporadic at the beginning and then it was mostly eruptive. And the epidemic wave could be seen, even mild, in each district. 2. The epidemic state at Kumayama-cho was clarified by the election of the most appro priate cases connecting the prevalence of each part of the district. 3. Studying the epidemic pattern on the village unit at each district, the connective spreading type of the prevalence was a few at the first year, but it was clearly observed on most of the cases at the second year, after obtaining the proof that the occurrence of the patients at the second year was the occurrence of the cases contracting the latent and unsignificant infection at the first year and the cases thought to be the common course infection were extremely a few. 4. The percentage of contraction at each district was 2.36-4.77%.
en-copyright=
kn-copyright=

en-aut-name=OnoNobuhiro
en-aut-sei=Ono
en-aut-mei=Nobuhiro
kn-aut-name=小野延宏
kn-aut-sei=小野
kn-aut-mei=延宏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=1
article-no=
start-page=279
end-page=286
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19591230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immunological Studies on Epidemic Hepatitis Part I Studies on the Prevalence of Epidemic Hepatits
kn-title=流行性肝炎の疫学的研究 第1編 流行性肝炎の流行について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The prevalence of epidemic hepatitis at Kumayama-cho, Akayuwa-gun in Okayama prefecture was fully observed for 3 years and the epidemic transition was studied. And the results were as follows. 1. The prevalence of epidemic hepatitis diffusely distributed to each age showing the apex at the second decade and third decade, but it showed the low rate at the first decade. And it showed the percentage of contration with a little rise and fall in all ages at the first year and it changed to show the distribution of age distinction with the apex at the third decade and the similar wave at the second decade at the second year. These relation were explained by the immunological distoribution caused by the past prevalence. The contracted cases over 70 years old were not always few. 2. No fixed relation was not clarified on the sex distinction. 3. Studying the occured state of every month in each year and each district, the sporadic prevalence was only seen in each district at the begining of the prevalence and the seasonal feature was not seen at the first year of the prevalence, but the occurrence of epidemic hepatitis was mostly seen in July, August and September and it was rather numerous inMay, June and October at the second and third year. On the other word, the prevalence of epidemic hepatitis after the second year had a seasonal feature. 4. The recurrent rate of epidemic hepatitis was 13.94%, and the age with the frequent recurrence was at the second decade and then the third decade and the recurrent season was mostly seen in December, then June, July and October. On the other word, it was fit for the season at which time the resistence of physical strength became declined. 5. The infection rate of family was 42.83% (16-76%), and the member of occureence in same family was 2 members per one family in most of the cases and then 3 members. 6. The calculation of the incubation by the family infection was not proper and it was difficult to clarify the simultaneous infection, gradual infection or infection from the cutside of family.
en-copyright=
kn-copyright=

en-aut-name=OnoNobuhiro
en-aut-sei=Ono
en-aut-mei=Nobuhiro
kn-aut-name=小野延宏
kn-aut-sei=小野
kn-aut-mei=延宏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=8-9
article-no=
start-page=819
end-page=822
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1962
dt-pub=19620930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Remote Results of Epidemic Hepatitis On the Prevalence of Epidemic Hepatitis at Kagato-Cho, Wake-Gun, Okayama
kn-title=流行性肝炎の遠隔成績（和気郡香登町の流行について）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A thourough examination was performed on the 319 cases, passed for more than one year after the release of treatment under the diagnosis of recovery or after the suspension of treatment at Kagato-Cho, Wake-Gun, Okayama in where there were prevalence of mild abortive form of epidemic hepatitis. 1. The cases having subjective symptom were 201 caces (63.0%) and their complaints were mainly the same to those on the course of disease. 2. Hepatomegaly in 77 cases (21.0%) and splenomegaly in 7 cases (2.2%) were ebserved. 3. Cases showing impairment in liver function test were 5.6-10.3% and cases showing a mild hyperbilirubinemia were 10 cases. 4. From the above results, cases required of treatment were 7 (2.2%), cases required of care 36 cases (11.3%). The concept that recovery of epidemic hepatitis was difficults was supported with the above results. 5. In the epidemics patients being required of treatment consisted of the second and third decades. 6. Duriug the last seven years, 1957 to 1963, 67 (21.3%) out of 314 cases of infections hepatitis in the epidemic areas developed into chronic hepatitis. 7. Acute stage of hepatitis at the onset was classified into three forms; typical, abortive and subclinical ones. 40.4% of the typical, 22.7% of the abortive and 36.2% of subclinical form progressed into chronic stage. Attention should be drawn to the high percentage of chronisity from the subclinical form of infectious hepatitis.
en-copyright=
kn-copyright=

en-aut-name=KosakaKiyowo
en-aut-sei=Kosaka
en-aut-mei=Kiyowo
kn-aut-name=小坂淳夫
kn-aut-sei=小坂
kn-aut-mei=淳夫
aut-affil-num=1
ORCID=

en-aut-name=NagashimaHideo
en-aut-sei=Nagashima
en-aut-mei=Hideo
kn-aut-name=長島秀夫
kn-aut-sei=長島
kn-aut-mei=秀夫
aut-affil-num=2
ORCID=

en-aut-name=YamamotoShigeru
en-aut-sei=Yamamoto
en-aut-mei=Shigeru
kn-aut-name=山本繁
kn-aut-sei=山本
kn-aut-mei=繁
aut-affil-num=3
ORCID=

en-aut-name=OhtaYasuyuki
en-aut-sei=Ohta
en-aut-mei=Yasuyuki
kn-aut-name=太田康幸
kn-aut-sei=太田
kn-aut-mei=康幸
aut-affil-num=4
ORCID=

en-aut-name=KondoTadasuke
en-aut-sei=Kondo
en-aut-mei=Tadasuke
kn-aut-name=近藤忠亮
kn-aut-sei=近藤
kn-aut-mei=忠亮
aut-affil-num=5
ORCID=

en-aut-name=ShinoharaToshio
en-aut-sei=Shinohara
en-aut-mei=Toshio
kn-aut-name=篠原敏夫
kn-aut-sei=篠原
kn-aut-mei=敏夫
aut-affil-num=6
ORCID=

en-aut-name=UedaUtaka
en-aut-sei=Ueda
en-aut-mei=Utaka
kn-aut-name=植田胖
kn-aut-sei=植田
kn-aut-mei=胖
aut-affil-num=7
ORCID=

en-aut-name=AsadaKiyotaka
en-aut-sei=Asada
en-aut-mei=Kiyotaka
kn-aut-name=浅田清隆
kn-aut-sei=浅田
kn-aut-mei=清隆
aut-affil-num=8
ORCID=

en-aut-name=KajiMasayoshi
en-aut-sei=Kaji
en-aut-mei=Masayoshi
kn-aut-name=加地正義
kn-aut-sei=加地
kn-aut-mei=正義
aut-affil-num=9
ORCID=

en-aut-name=EndoKenichi
en-aut-sei=Endo
en-aut-mei=Kenichi
kn-aut-name=遠藤憲一
kn-aut-sei=遠藤
kn-aut-mei=憲一
aut-affil-num=10
ORCID=

en-aut-name=AisakaTadakazu
en-aut-sei=Aisaka
en-aut-mei=Tadakazu
kn-aut-name=相坂忠一
kn-aut-sei=相坂
kn-aut-mei=忠一
aut-affil-num=11
ORCID=

en-aut-name=TakagaiNaoteru
en-aut-sei=Takagai
en-aut-mei=Naoteru
kn-aut-name=高木直輝
kn-aut-sei=高木
kn-aut-mei=直輝
aut-affil-num=12
ORCID=

en-aut-name=KobashiNobuo
en-aut-sei=Kobashi
en-aut-mei=Nobuo
kn-aut-name=小橋暢夫
kn-aut-sei=小橋
kn-aut-mei=暢夫
aut-affil-num=13
ORCID=

en-aut-name=KitagawaYukinori
en-aut-sei=Kitagawa
en-aut-mei=Yukinori
kn-aut-name=北川紀典
kn-aut-sei=北川
kn-aut-mei=紀典
aut-affil-num=14
ORCID=

en-aut-name=NukataKaname
en-aut-sei=Nukata
en-aut-mei=Kaname
kn-aut-name=額田要
kn-aut-sei=額田
kn-aut-mei=要
aut-affil-num=15
ORCID=

en-aut-name=OnoNobuhiro
en-aut-sei=Ono
en-aut-mei=Nobuhiro
kn-aut-name=小野延宏
kn-aut-sei=小野
kn-aut-mei=延宏
aut-affil-num=16
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=10
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=11
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=12
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=13
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=14
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=15
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=16
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=1
article-no=
start-page=113
end-page=126
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1965
dt-pub=19650130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical Study on Rheumatoid Foot
kn-title=リウマチ足に関する臨床的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Despite the fact that the pathologic changes of the foot in rheumatoid arthritis are quite specific and common, studies on statistics and pathomechanism of rheumatoid foot are relatively rare. In view of this, clinical and X-ray studies as well as study on pathomechanism of deformation of foot were carried out with 103 patients of rheumatoid foot (182 foot) that visited the outpatient ward of Orthopaedic Surgery of Okayama University for the period covering from January 1963 to March 1964. The results are in the following. It has been found that the rheumatoid patients having pathologic changes of the foot amounted to 56% , showing the incidence to be higher than what is generally thought. It is to be noted that the sites where pathologic change of ankle joint proved to be most severe are the anterior and posterior regions of medial and lateral malleolus, followed by Chopart's joint, and these proved to be the main factors for talipes planovalgus. Rep esentative deformations of the rheumatoid foot are eversion of heel, talipes planus, hallux valgus, and hammer toe. The onset mechanism of these deformations may be explained as to start with inflammation of synovial membrane due to rheumatism, which is followed by the weakening of ligaments and muscles constituting the joint capsule and the joint, then the subsequent accumulation of static and kinesiologic factor makes the pathologic deformation definitive. Differences between rheumatoid hand and rheumatoid foot are not only limited to local inflammation and anatomical elements, but also to the foot there arises an additional problem of weight bearing. With respect to functional disturbances in the case of a rheumatoid foot main complaints are less in spite of the injury of bone and deformation. when the comparison is made between Europeans and Americans on one hand and Japanese on the other, differences in the modes of living have a telling influence, and of Japanese people with rheumatoid feet they may experience some inconvenience in their routines of life but they are not so much bothered by their functional disturbance.
en-copyright=
kn-copyright=

en-aut-name=OnodaTaro
en-aut-sei=Onoda
en-aut-mei=Taro
kn-aut-name=小野田太郎
kn-aut-sei=小野田
kn-aut-mei=太郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部整形外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=83
cd-vols=
no-issue=7-8
article-no=
start-page=259
end-page=265
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1971
dt-pub=19710830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=昭和43年度および44年度Acatalasemia, Hypocatalasemia調査集計
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=高原滋夫
kn-aut-sei=高原
kn-aut-mei=滋夫
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小倉義郎
kn-aut-sei=小倉
kn-aut-mei=義郎
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野田元男
kn-aut-sei=小野田
kn-aut-mei=元男
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=大島昭夫
kn-aut-sei=大島
kn-aut-mei=昭夫
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=住田昭三
kn-aut-sei=住田
kn-aut-mei=昭三
aut-affil-num=5
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=滝口峻
kn-aut-sei=滝口
kn-aut-mei=峻
aut-affil-num=6
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=尾関安英
kn-aut-sei=尾関
kn-aut-mei=安英
aut-affil-num=7
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=笠井英夫
kn-aut-sei=笠井
kn-aut-mei=英夫
aut-affil-num=8
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=黒田泰生
kn-aut-sei=黒田
kn-aut-mei=泰生
aut-affil-num=9
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=大倉興司
kn-aut-sei=大倉
kn-aut-mei=興司
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=10
en-affil=
kn-affil=東京医科歯科大学人類遺伝研究室
END

start-ver=1.4
cd-journal=joma
no-vol=87
cd-vols=
no-issue=1-2
article-no=
start-page=65
end-page=69
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1975
dt-pub=19750228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical Effect of Menaquinone on Bronchial Asthma
kn-title=気管支喘息におけるMenaquinone (vit. K(2))の臨床効果について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A series of 191 patients of bronchial asthma were treated with menaquinone for not less than one year, and the clinical effect of the drug was investigated. 1) The therapy with menaquinone only gave effective rate of 90.0% (a marked effective rate of 42.4%) in mild patients, an effective of 86.7% (a marked effective rate of 30.0%) in moderate patients, and an effective rate of 72.2% (a marked effective rate of 27.3%) in severe patients. namely, considerably high effective rates were attained by the therapy in the respective patients. 2) The therapy with menapuinone, in conjunction with hyposensitization therapy, gave an effective rate of 100% (a marked effective rate of 33.3%) in mild patient, and an effective rate of 93.8% (a marked effective rate of 34.4%) in moderate patients, but such a low effective rate as 60% (a marked effective rate of 10%) in severe patients. It was revealed that menaquinone therapy is more effective, when employed in conjunction with hyposensitization. 3) The double blind stuby of the clinical effects of menaquinon revealed that the placebo used in the study was effective on only 16.7% of the patients treated with it, and that the incidence of recurrence due to discontinuance of menaquinone therapy tended to be low in patients treated with the drug for long periods.
en-copyright=
kn-copyright=

en-aut-name=KimuraIkuro
en-aut-sei=Kimura
en-aut-mei=Ikuro
kn-aut-name=木村郁郎
kn-aut-sei=木村
kn-aut-mei=郁郎
aut-affil-num=1
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=2
ORCID=

en-aut-name=SatoSuichi
en-aut-sei=Sato
en-aut-mei=Suichi
kn-aut-name=佐藤周一
kn-aut-sei=佐藤
kn-aut-mei=周一
aut-affil-num=3
ORCID=

en-aut-name=SaitoKatsuyoshi
en-aut-sei=Saito
en-aut-mei=Katsuyoshi
kn-aut-name=斉藤勝剛
kn-aut-sei=斉藤
kn-aut-mei=勝剛
aut-affil-num=4
ORCID=

en-aut-name=TakahashiKiyoshi
en-aut-sei=Takahashi
en-aut-mei=Kiyoshi
kn-aut-name=高橋清
kn-aut-sei=高橋
kn-aut-mei=清
aut-affil-num=5
ORCID=

en-aut-name=UedaNobuo
en-aut-sei=Ueda
en-aut-mei=Nobuo
kn-aut-name=上田暢男
kn-aut-sei=上田
kn-aut-mei=暢男
aut-affil-num=6
ORCID=

en-aut-name=OnoHatsuko
en-aut-sei=Ono
en-aut-mei=Hatsuko
kn-aut-name=小野波津子
kn-aut-sei=小野
kn-aut-mei=波津子
aut-affil-num=7
ORCID=

en-aut-name=MoritaniYoshiaki
en-aut-sei=Moritani
en-aut-mei=Yoshiaki
kn-aut-name=守谷欣明
kn-aut-sei=守谷
kn-aut-mei=欣明
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学平木内科

affil-num=2
en-affil=
kn-affil=岡山大学平木内科

affil-num=3
en-affil=
kn-affil=岡山大学平木内科

affil-num=4
en-affil=
kn-affil=岡山大学平木内科

affil-num=5
en-affil=
kn-affil=岡山大学平木内科

affil-num=6
en-affil=
kn-affil=岡山大学平木内科

affil-num=7
en-affil=
kn-affil=岡山大学平木内科

affil-num=8
en-affil=
kn-affil=岡山大学平木内科
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=9-10
article-no=
start-page=1261
end-page=1265
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19771030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical studies on buckwheat allergy
kn-title=そばアレルギー症に関する臨床的検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A skin test using buckwheat extract was performed on 182 cases of bronchial asthma. Thirty-three of them showed a positive skin test to buckwheat extract. Buckwheat allergy (bronchial asthma, urticaria, allergic rhinitis, allergic gastroenteropathy and allergic conjunctivities) was found in 19 (57.6%) of the 33 cases showing a positive skin test to buckwheat extract. Basophils from 8 cases of buckwheat asthma showed a strong response to buckwheat extract, although basophils from 10 cases with a postive skin test only, without buckwheat allergy, did not response to buckwheat extract. Bronchial asthma induced by buckwheat (16 of the 19 cases) had some special features. Their asthma attack was induced by the introduction into the body through either mouth or airway and started in childhood. Buckwheat pillows were used in 13 of the 19 cases. Ten of the 13 cases obtained alleviation of asthma upon discontinuation of buckwheat pillows. Most of the buckwheat asthma patients showed a high serum IgE level and had a hereditary factor. The results showed that cases of buckwheat asthma might be sensitized in their childhood.
en-copyright=
kn-copyright=

en-aut-name=TanizakiY
en-aut-sei=Tanizaki
en-aut-mei=Y
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=1
ORCID=

en-aut-name=TakahashiK
en-aut-sei=Takahashi
en-aut-mei=K
kn-aut-name=高橋清
kn-aut-sei=高橋
kn-aut-mei=清
aut-affil-num=2
ORCID=

en-aut-name=UedaN
en-aut-sei=Ueda
en-aut-mei=N
kn-aut-name=上田暢男
kn-aut-sei=上田
kn-aut-mei=暢男
aut-affil-num=3
ORCID=

en-aut-name=SaitoK
en-aut-sei=Saito
en-aut-mei=K
kn-aut-name=斉藤勝剛
kn-aut-sei=斉藤
kn-aut-mei=勝剛
aut-affil-num=4
ORCID=

en-aut-name=HosokawaM
en-aut-sei=Hosokawa
en-aut-mei=M
kn-aut-name=細川正雄
kn-aut-sei=細川
kn-aut-mei=正雄
aut-affil-num=5
ORCID=

en-aut-name=OnoH
en-aut-sei=Ono
en-aut-mei=H
kn-aut-name=小野波津子
kn-aut-sei=小野
kn-aut-mei=波津子
aut-affil-num=6
ORCID=

en-aut-name=IshibashiK
en-aut-sei=Ishibashi
en-aut-mei=K
kn-aut-name=石橋健
kn-aut-sei=石橋
kn-aut-mei=健
aut-affil-num=7
ORCID=

en-aut-name=GodaY
en-aut-sei=Goda
en-aut-mei=Y
kn-aut-name=合田吉徳
kn-aut-sei=合田
kn-aut-mei=吉徳
aut-affil-num=8
ORCID=

en-aut-name=NakamuraY
en-aut-sei=Nakamura
en-aut-mei=Y
kn-aut-name=中村之信
kn-aut-sei=中村
kn-aut-mei=之信
aut-affil-num=9
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=佐々木良英
kn-aut-sei=佐々木
kn-aut-mei=良英
aut-affil-num=10
ORCID=

en-aut-name=MoritaniY
en-aut-sei=Moritani
en-aut-mei=Y
kn-aut-name=守谷欣明
kn-aut-sei=守谷
kn-aut-mei=欣明
aut-affil-num=11
ORCID=

en-aut-name=KimuraY
en-aut-sei=Kimura
en-aut-mei=Y
kn-aut-name=木村郁郎
kn-aut-sei=木村
kn-aut-mei=郁郎
aut-affil-num=12
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学第二内科

affil-num=2
en-affil=
kn-affil=岡山大学第二内科

affil-num=3
en-affil=
kn-affil=岡山大学第二内科

affil-num=4
en-affil=
kn-affil=岡山大学第二内科

affil-num=5
en-affil=
kn-affil=岡山大学第二内科

affil-num=6
en-affil=
kn-affil=岡山大学第二内科

affil-num=7
en-affil=
kn-affil=岡山大学第二内科

affil-num=8
en-affil=
kn-affil=岡山大学第二内科

affil-num=9
en-affil=
kn-affil=岡山大学第二内科

affil-num=10
en-affil=
kn-affil=岡山大学第二内科

affil-num=11
en-affil=
kn-affil=岡山大学第二内科

affil-num=12
en-affil=
kn-affil=岡山大学第二内科
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=1-2
article-no=
start-page=17
end-page=31
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19780228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Scanning electron microscope studies on microvascular architecture of bone marrow Report Ⅱ. Injection replica scanning electron microscope study on venous system of rat femoral bone marrow
kn-title=骨髄血管構築の走査電子顕微鏡的研究 第2編 ラット大腿骨骨髄の静脉系に関する鋳型走査電子顕微鏡的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In Part I, the author reported that the injection replica scanning electron microscope method using methylmethacrylate was a highly effective means for elucidating the microvascular architecture of the bone marrow and presented his findings on the arterial system. A report on the venous system is provided in Part 2. The nutrient vein runs parallel avove the nutrient artery. After it enters the bone marrow, it bifurcates into ascending and descending central veins. The ascending branch curves and bends gently to the proximal end of the femur while the descending branch also bends and curves gently to a point close to the distal end where it divides furthe into 3 to 4 branches. Enroute, numerous sinusoids and collecting sinusoids flow into central vein. Collecting sinusoids of various shapes were observed. The sinusoid is composed of a stereoscopic net-like architecture which extends over the whole bone marrow with the mesh being fine on the superficial zone and rather coarse on the deep zone. No intrasinusoidal capillaries could be observed. All capillaries connected to the sinusoid are considered to the arteries. Thus, with the injection replica scanning electron microscope method using methylmethacrylate, it is also possible to clarify the venous system of the bone marrow.
en-copyright=
kn-copyright=

en-aut-name=OnoTetsuya
en-aut-sei=Ono
en-aut-mei=Tetsuya
kn-aut-name=小野哲也
kn-aut-sei=小野
kn-aut-mei=哲也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学第二内科
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=1-2
article-no=
start-page=1
end-page=16
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19780228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Scanning electron microscope studies on microvascular architecture of bone marrow Report I. Injection replica scanning electron microscope study on arterial system of rat femoral bone marrow
kn-title=骨髄血管構築の走査電子顕微鏡的研究 第1編 ラット大腿骨骨髄の動詠系に関する鋳型走査電子顕微鏡的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A JSM-U3 type scanning electron microscope was used to conduct stereoscopic and continuous observation and photography of the microvascular architecture of the rat femoral bone marrow by the injection replica method using methylmethacrylate. The nutrient artery passes through the nutrient foramen at an angle of 30 on the proximal and inner side of the femur to the bone marrow and bifurcates into ascending and descending branches. The ascending branch continues to run proximally, while the descending branch further divides into 3 immediately after the branching and all 3 bend and curve as they continue to proceed distally and eventually separate into numerous arterial branches. Approximately 1/3 of the bone marrow which is located near the nutrient foramen is linked to the arterial branch which has divided in the nutrient foramen. This arterial branch passes between the sinusoid and proceeds to a point comparatively close to the surface of the bone marrow where it separates into finer branches and flows into the sinusoid. It is considered that the distal two thirds of the bone marrow is connected to the arterial branches which divided from the descending branch. There are also branches which pass through the periosteum to the Haversian canal, enter the bone marrow and connect with the sinusoid. The opening of the arterial capillaries assumes various shapes such as gradual and steep funnellike to right angle orifices. The injection replica scanning electron microscope method is a highly effective means for elucidating microvascular architecture such as that of the bone marrow and it is felt the author was quite successful in clarifying the microvascular archtecture of the bone marrow.
en-copyright=
kn-copyright=

en-aut-name=OnoTetsuya
en-aut-sei=Ono
en-aut-mei=Tetsuya
kn-aut-name=小野哲也
kn-aut-sei=小野
kn-aut-mei=哲也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学第二内科
END

start-ver=1.4
cd-journal=joma
no-vol=121
cd-vols=
no-issue=3
article-no=
start-page=169
end-page=171
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A retrospective study of the PROLENE hernia system comparedwith the mesh-plug technique
kn-title=成人鼠径ヘルニア手術症例の臨床的検討：Mesh plug 法と PROLENE hernia system の比較
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To compare the results of the PROLENE hernia system (PHS) and mesh-plug technique (MPT), a retrospective study of adult patients with inguinal hernia was performed. The total number of inguinal herniorrhaphies for the past 9 years was 376, and the numbers of operative treatments by PHS, MPT and the Bassini procedure were 79, 291 and 6, respectively. There were no significant differences either in the operating time or the hospitalization days. No postoperative complications were observed in the PHS group; however, 8 complications were found among the 291 cases (2.75 %) of the MPT group (hematoma, 3 ; seroma, 2 ; testitis, 1 ; mesh infection, 2). Out of the total 376 cases, the number of initial and recurrence cases was 355 and 21, respectively, and out of the 21 recurrence cases the number of initial surgeries by Bassini and MPT was 14 and 7, respectively. Among the 21 recurrence cases there were no recurrences after PHS.
en-copyright=
kn-copyright=

en-aut-name=HamanoRyosuke
en-aut-sei=Hamano
en-aut-mei=Ryosuke
kn-aut-name=濱野亮輔
kn-aut-sei=濱野
kn-aut-mei=亮輔
aut-affil-num=1
ORCID=

en-aut-name=OhtsukaShinya
en-aut-sei=Ohtsuka
en-aut-mei=Shinya
kn-aut-name=大塚眞哉
kn-aut-sei=大塚
kn-aut-mei=眞哉
aut-affil-num=2
ORCID=

en-aut-name=FujiiSayaka
en-aut-sei=Fujii
en-aut-mei=Sayaka
kn-aut-name=藤井清香
kn-aut-sei=藤井
kn-aut-mei=清香
aut-affil-num=3
ORCID=

en-aut-name=NishieManabu
en-aut-sei=Nishie
en-aut-mei=Manabu
kn-aut-name=西江学
kn-aut-sei=西江
kn-aut-mei=学
aut-affil-num=4
ORCID=

en-aut-name=TokunagaNaoyuki
en-aut-sei=Tokunaga
en-aut-mei=Naoyuki
kn-aut-name=徳永尚之
kn-aut-sei=徳永
kn-aut-mei=尚之
aut-affil-num=5
ORCID=

en-aut-name=TsunemitsuYosuke
en-aut-sei=Tsunemitsu
en-aut-mei=Yosuke
kn-aut-name=常光洋輔
kn-aut-sei=常光
kn-aut-mei=洋輔
aut-affil-num=6
ORCID=

en-aut-name=IwakawaKazuhide
en-aut-sei=Iwakawa
en-aut-mei=Kazuhide
kn-aut-name=岩川和秀
kn-aut-sei=岩川
kn-aut-mei=和秀
aut-affil-num=7
ORCID=

en-aut-name=InagakiMasaru
en-aut-sei=Inagaki
en-aut-mei=Masaru
kn-aut-name=稲垣優
kn-aut-sei=稲垣
kn-aut-mei=優
aut-affil-num=8
ORCID=

en-aut-name=OhsakiToshihide
en-aut-sei=Ohsaki
en-aut-mei=Toshihide
kn-aut-name=大崎俊英
kn-aut-sei=大崎
kn-aut-mei=俊英
aut-affil-num=9
ORCID=

en-aut-name=IwagakiHiromi
en-aut-sei=Iwagaki
en-aut-mei=Hiromi
kn-aut-name=岩垣博巳
kn-aut-sei=岩垣
kn-aut-mei=博巳
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=独立行政法人国立病院機構福山医療センター　外科

affil-num=2
en-affil=
kn-affil=独立行政法人国立病院機構福山医療センター　外科

affil-num=3
en-affil=
kn-affil=独立行政法人国立病院機構福山医療センター　外科

affil-num=4
en-affil=
kn-affil=独立行政法人国立病院機構福山医療センター　外科

affil-num=5
en-affil=
kn-affil=独立行政法人国立病院機構福山医療センター　外科

affil-num=6
en-affil=
kn-affil=独立行政法人国立病院機構福山医療センター　外科

affil-num=7
en-affil=
kn-affil=独立行政法人国立病院機構福山医療センター　外科

affil-num=8
en-affil=
kn-affil=独立行政法人国立病院機構福山医療センター　外科

affil-num=9
en-affil=
kn-affil=独立行政法人国立病院機構福山医療センター　外科

affil-num=10
en-affil=
kn-affil=独立行政法人国立病院機構福山医療センター　外科
en-keyword=鼠径ヘルニア (inguinal hernia)
kn-keyword=鼠径ヘルニア (inguinal hernia)
en-keyword=mesh plug 法 (mesh plug technique)
kn-keyword=mesh plug 法 (mesh plug technique)
en-keyword=PROLENE hernia system
kn-keyword=PROLENE hernia system
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=7-8
article-no=
start-page=819
end-page=849
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19770830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical and experimental study on the influence of cellular immune response in establishment of autotransplantation of autochothonous tumor-Analysis of their relationship by blastogenic activity of lymphoid cell
kn-title=悪性腫瘍自家移植の成立におよぼす細胞性免疫能,とくにphytohemagglutininに対するリンパ球幼若化能の影響に関する臨床的ならびに実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1) T cell population and blastogenic activity against both phytohemagglutinin (PHA) and pokeweek mitogen (PWM) were assayed in twenty patients, whose malignant neoplasma had been eradicated by surgery before more than six months, when the first clinical evidence of the recurrence was observed during the period of postoperative control. A deterioration of the blastogenic activity of the lymphocyte to PHA was highly significant, compaired with that in healthy subjects and patients who have had radical surgery for their neoplasm but showed no evidence of the recurrence. It was noted that this deterioration occurred regardlessly of the interval between the surgery and the recurrence and also of the mode of recurrent lesion. No remarkable differences were observed in the T cell population and the blastogenic activity to PWM among these three groups. 2) Swiss mice were undergone subcutaneous autotransplantation of isolated tumor cells from their own methylcholanthrene-induced leg sarcoma after surgical removal of the tumor. The establishment of the autotransplantation and the growth of the tumor was daily observed and the blastogenic activity of the splenic lymphocyte to PHA was assayed 14 days after the tumor implantation. Neither a period before the tumor take nor cumulative incidence of the take were correlated with the blastogenic activity of the splenic cell. However, the individual size of the tumors 14 days after the transplantation was markedly smaller in mice having the blastogenic activity higher than the mean value in the group than in those having the activity lower than the mean. Thus the reverse correlation between the tumor size and the blastogenic activity ratio were statistically significant (p<0.01). An additional skin homograft performed simultaneously with the tumor inoculation resulted in the apparent increase in the number of the mice showing the blastogenic ratio higher than the mean in the non-grafted control, and this caused further inhibition of the tumor growth, showing also the significant reverse correlatio between the tumor size and the blastogenic ratio (p<0.01). B. C. G. inoculation, before, at and after the tumor transplantation, caused marked decrease in the mitogenic activity of the splenic cell, but the tumor growth was significantly detarded and the reverse correlation between the tumor size and the blastogenic ratio among the individual mice was preserved as in the above two experiments. In mice administered with Cephranthin, daily for 14 successive days starting with the tumor transplantation, the tumor growth inhibition of slight grade was observed as late as 14 days following the tumor inoculation and no significant effect on the blastogenic activity of the splenic cell was observed, and though the reverse correlation above was affirmed it was not highly significant (p<0.05). 3) From the results mentioned above, the author intended to conclude that the reverse correlation between tumor growth and blastogenic activity of the lymphoid cell does exist and even the nonspecific immunopotentiation contribute to bestow the ability for the lymphoid cell to suppress the tumor growth by potentiation of the blastogenic activity, even in mechanism of establishment of autotransplantation of malignant tumor in the subject whose malignant neoplasma was eradicated, as in cancer bearing hosts. Additionally, the possibility that deterioration of the blastogenic activity of the lymphoid cell may play a role of triggering effect for dormant cancer cell to obtain a growing ability was presumed and a possibility of significant contribution to this mechanism of cell- mediated cancer immunity other than that can be assessed by mitogenic activity of the lymphoid cell was also discussed.
en-copyright=
kn-copyright=

en-aut-name=OnoKensaku
en-aut-sei=Ono
en-aut-mei=Kensaku
kn-aut-name=小野監作
kn-aut-sei=小野
kn-aut-mei=監作
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=7-8
article-no=
start-page=793
end-page=817
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19770830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The effect of serum alpha 1-antitrypsin on the fibrinolytic system in cancer patients
kn-title=担癌病態におけるα(1)―antitrypsinに関する臨床的研究-とくに根治手術前後における線溶現象への関与について―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The α(1)-antitrypsin (α(1)AT), which comprises more than 90 % of the protein content of the α(1)-globulin, inhibits a variety of enzyme. α(1)AT is the major trypsin inhibitor in human serum and has an important role as antiplasmin in fibrinolytic system. The experiments were carried out to investigate the effect of α(1)AT on fibrinolytic system, measuring serum α(1)AT levels and coagulative and fibrinolytic activities in man. The serum α(1)AT levels were measured in 30 controls, 93 cancer and 107 nonmalignant patients. They were also measured in the postoperative patients who were 7 cases of gastric cancer, 5 of lung cancer, 5 of breast cancer and 5 of cholelithiasis. The serum levels were measured by a single radial immunodiffusion plate (M-partigen) obtained from the Behring Institute. The results obtained were as follows: 1) The levels of α(1)AT were significantly increased in patients with lung cancer, gastric cancer and colon cancer, while those with breast cancer and thyroid cancer remained in normal range. There was a significant correlation between α(1) AT and the clinical stage of lung cancer and gastric cancer. Among nonmalignant patients, AT was significantly elevated in the inflammatory diseases such as lung abscess and hepatitis. 2) α(1)AT had the lowerest level at the end of operation and it exceeded the preoperative value and returned to preoperative level at the 14th day. These changes of α(1)AT were observed both cancer and nonmalignant patients. The plasma fibrinogen levels showed a similar pattern to α(1)AT during postoperative period, whereas d(2)-macroglobulin had no significant changes. The concentration of plasma plasminogen and antithrombin III had been fallen below the preoperative levels by the 7th day and returned at the 14th day. Antitrypsin activities were increased to some extent by the 7th postoperative day. These results suggest that the elevation of α(1)AT is closely related to two factors as follows: a) α(1)AT may increase to neutralize a certain leucocytic protease when leucocytes increase in body. b) The increase in α(1)AT might be due to regulating the plasmin which auguments in cancer, inflammation or postoperative patients, may induce release of antiplasmin whose activity is mainly dependent on α(1)AT.
en-copyright=
kn-copyright=

en-aut-name=OnoYoshihiko
en-aut-sei=Ono
en-aut-mei=Yoshihiko
kn-aut-name=小野好彦
kn-aut-sei=小野
kn-aut-mei=好彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=94
cd-vols=
no-issue=9-10
article-no=
start-page=951
end-page=965
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=19821030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Evaluation of Levamisole as Immunomodulator in Advanced Gastric Cancer
kn-title=Levamisoleを用いた進行胃癌免疫化学療法の臨床効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The efficacy of Levamisole (LMS) was studied on prolongation of patient survival and modulation of cellular immunity in a total of 220 cases of gastric cancer (136 cases for control and 84 cases for LMS group). In the study, detailed analyses were performed in 64 cases of stage Ⅲ, in which LMS therapy was effective and influence of background factors was minimum (32 cases for control and 32 cases for LMS group). LMS was administered 150mg/day for three consecutive days every other week beginning from three days before operation, and was continued more than than two months and upto two years. The results obtained were as follows: 1) In cases of gastric cancer, the survival rate of the LMS group, was significantly higher than that of the control group (p<0.05). Furthermore, the efficacy of LMS on prolongation of survival rate was remarkable in the group of stage Ⅲ (p<0.05). 2) A detailed study in the group of stage Ⅲ was performed and resulted in the following: First, when stage Ⅲ cases were classified into curative and noncurative cases, LMS was effective in prolonging the survival of patients who received curative resection. Secondly, the efficacy of LMS was investigated in terms of tumor size. No difference in patient survival was observed between the control and LMS group, when tumor size was less than 3.9cm or more than 8.0cm in diameter. However, a significant effect of LMS therapy was detected for cases whose tumor was between 4.0cm and 7.9cm in diameter and depth of invasion was se (P<0.05). Thirdly, influence of lymph node metastasis on the effect of LMS was analysed. LMS was effective to a significant degree if the metastasis did not extend beyond lymph nodes classified in group I (n(1)) (p<0.05). Fourthly, when localization or histopathological grading of tumor was considered, the survival rate of LMS group tended to be high if the tumor was localized in the bulk of the corpus and belonged to a undifferentiated type. Fifthly, the (v) factor, grade of invasion into veins, was evaluated. LMS was effective in cases of v(0). And also, the efficacy of LMS was observed in cases classified as INF β in terms of form of infiltration. 3) Mitogen responses, cell number and T-cell percentage of peripheral blood lymphocytes and also PPD skin test were examined to evaluate immunological status of gastric cancer patients receiving LMS therapy. The data suggested that LMS activated promptly and normalized the cellular immunity in cases of advanced gastric cancer classified into stage Ⅲ and Ⅳ in which cellular immunity was reduced. By contrast, it was ineffective for cases of gastric cancer at early stages classified into stage Ⅰ and Ⅱ.
en-copyright=
kn-copyright=

en-aut-name=OnoFumio
en-aut-sei=Ono
en-aut-mei=Fumio
kn-aut-name=小野二三雄
kn-aut-sei=小野
kn-aut-mei=二三雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
en-keyword=Levamisole
kn-keyword=Levamisole
en-keyword=胃癌
kn-keyword=胃癌
en-keyword=生存率
kn-keyword=生存率
en-keyword=細胞性免疫能
kn-keyword=細胞性免疫能
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=高温条件下での生育にtrans-translationを必要とする大腸菌変異株の単離と解析
kn-title=Isolation and characterization of an Escherichia coli mutant which requires trans-translation for growth at high temperature
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnoKatsuhiko
en-aut-sei=Ono
en-aut-mei=Katsuhiko
kn-aut-name=小野勝彦
kn-aut-sei=小野
kn-aut-mei=勝彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=94
cd-vols=
no-issue=1-2
article-no=
start-page=141
end-page=150
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=19820228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical studies on pulmonary changes in patients with connective tissue disease. Part 2. Effects of steroid hormone against pulmonary fibrosis
kn-title=膠原病の肺病変に関する臨床的研究 第Ⅱ編 肺線維症の治療に関する臨床的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The therapeutic effect of steroid hormone(STH) against pulmonary fibrosis was evaluated in 6 patients with dermatomyositis(DM), 6 with progressive systemic sclerosis(PSS), 3 with rheumatoid arthritis(RA) and 5 with idiopathic pulmonary fibrosis(IPF). Of these patients, 7 were male and 13 were female. The average age was 46.5, ranging from 24 to 66 years old. Dosage of STH varied between 10mg and 40mg/day in each patient and the mean administration period was 14 months. Clinical effects were determined using chest X-ray film, % VC, PaO(2) and direct questioning. Twelve out of 20 patients improved after STH therapy. The clinical effectiveness of STH depended on the ground disease of patients with pulmonary fibrosis; that is, STH was most effective against pulmonary fibrosis in patients with DM and less effective in patients with PSS. STH was also effective in patients with acute stage IPF, but not in patients with chronic IPF. STH seemed to be dose dependent, being more effective in patients with the high dosage of STH. Nodular shadows on chest X-ray film were more sensitive to STH therapy than reticular shadows. Moreover, % VC and PaO(2) seemed to be useful for judging the effectiveness of STH therapy.
en-copyright=
kn-copyright=

en-aut-name=OnoKaname
en-aut-sei=Ono
en-aut-mei=Kaname
kn-aut-name=小野要
kn-aut-sei=小野
kn-aut-mei=要
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第3内科学教室
en-keyword=膠原病
kn-keyword=膠原病
en-keyword=肺線維症
kn-keyword=肺線維症
en-keyword=ステロイドホルモン
kn-keyword=ステロイドホルモン
END

start-ver=1.4
cd-journal=joma
no-vol=94
cd-vols=
no-issue=1-2
article-no=
start-page=131
end-page=140
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=19820228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical studies on pulmonary changes in patients with connective tissue disease. Part 1. Clinical studies on pulmonary fibrosis
kn-title=膠原病の肺病変に関する臨床的研究 第1編 とくに肺線維症を中心とした臨床的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Pulmonary lesions appearing in chest X-ray films were studied in 24 patients with progressive systemic sclerosis(PSS), 25 with polymyositis and dermatomyositis(PM-DM), 30 with rheumatoid arthritis(RA), 37 with Hashimoto's thyroiditis(HT), 59 with Sjogren's syndrome(SS) and 18 with Behcet's syndrome(BS). Pulmonary fibrosing changes were most common in these patients. The incidence of pulmonary fibrosis in connective tissue disease was as follows: 17 patients(71%) in PSS, 16(64%) in PM-DM, 17(57%) if RA, 10(26%) in HT, 23(39%) in SS and 2(11%) in BS. Pulmonary emphysema was observed in 2 patients with SS and pulmonary infarction was observed in one patient with BS. Fibrotic changes were most severe in PSS, in which positive anti-lung antibody and involvement of the alimentary tract were ofen detected in patients with pulmonary fibrosis. Pulmonary fibrosis in DM correlated well with the titer of anti-lung antibody, but not with other laboratory findings such as anti-nuclear antibody, CH50, RF, CRP, transaminase, LDH or γ-globulin level. In RA, HT, SS and BS, there was no significant correlation between pulmonary fibrosis and the laboratory findings.
en-copyright=
kn-copyright=

en-aut-name=OnoKaname
en-aut-sei=Ono
en-aut-mei=Kaname
kn-aut-name=小野要
kn-aut-sei=小野
kn-aut-mei=要
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第3内科学教室
en-keyword=膠原病
kn-keyword=膠原病
en-keyword=膠原病近縁疾患
kn-keyword=膠原病近縁疾患
en-keyword=肺線維症
kn-keyword=肺線維症
en-keyword=間質性肺炎
kn-keyword=間質性肺炎
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=M-RIP，JNKシグナルの新しい標的であり，ヒト癌細胞の浸潤に必要である遺伝子
kn-title=M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OnoRyoko
en-aut-sei=Ono
en-aut-mei=Ryoko
kn-aut-name=小野亮子
kn-aut-sei=小野
kn-aut-mei=亮子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=9-10
article-no=
start-page=747
end-page=758
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19861031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A new precipitating antibody to the microsomal fraction in patients with connective tissue diseases
kn-title=膠原病における各種抗核抗体と関連したマイクロゾーム系の抗細胞質抗体の検出
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the course of studying the precipitin reactions between sera from patients with connective tissue diseases and the saline soluble extracts of young rabbit thymus acetone powder, a new precipitin system was observed, tentatively called the Tu system after the original serum. The Tu antigen activity was unaltered by heating up to 60℃ for 30 minutes, and was stable at pH values of 4 to 10. The precipitin activity was resistant to digestion by DNase and RNase, but partially sensitive to trypsin digestion, suggesting that a glycoprotein was associated with antigenicity. The average molecular weight of the Tu antigen was estimated to be 70,000 as determined by Sephadex G-200 chromatography analysis. The Tu antigen was localized in the cell cytoplasma, but not in cell nuclei nor nucleoli, as observed by indirect immunofluorescence and the peroxidase enzyme antibody technique. Cell fraction analysis by centrifuge methods clarified that the Tu antigen activity was in the microsomal fraction, mostly in the rough endoplasmic reticulum fraction. The Tu antibody was found in 31% of patients with progressive systemic sclerosis, in 20% with systemic lupus erythematosus, in 22% with mixed connective tissue disease and in 10-20% with other connective tissue diseases. The patients with this precipitin antibody in their sera also had antibodies to various non-histone nuclear protein antigens, including RNP, Sm, Scl-70, SS-A and SS-B. The Tu system was completely different from immune systems previously reported by others which included anti thyroid-specific microsomal antibodies, ubiquitous tissue antigen (UTA) and liver/kidney microsomal systems because of the non-identical precipitin lines and the difference in their disease distribution.
en-copyright=
kn-copyright=

en-aut-name=OnoderaHideo
en-aut-sei=Onodera
en-aut-mei=Hideo
kn-aut-name=小野寺英朗
kn-aut-sei=小野寺
kn-aut-mei=英朗
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第三内科教室
en-keyword=anti cytoplasmic antibody
kn-keyword=anti cytoplasmic antibody
en-keyword=anti microsomal antibody
kn-keyword=anti microsomal antibody
en-keyword=anti Tu antibody
kn-keyword=anti Tu antibody
en-keyword=anti nuclear antibody
kn-keyword=anti nuclear antibody
en-keyword=connective tissue disease
kn-keyword=connective tissue disease
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=7-8
article-no=
start-page=607
end-page=612
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19860830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of pH changes on action of non-depolarizing muscle relaxants
kn-title=非脱分極性筋弛緩薬の作用に及ぼす酸-塩基平衡の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effect of pH changes on neuromuscular (NM) transmission, both in the presence and in the absence of muscle relaxants (MR), was investigated using phrenic nervehemidiaphragm preparations of rats. The first finding of this study indicated that the primary site of action of pH changes in the absence of MR is muscle itself and not the NM junction. The second finding was that the effect of pH changes on the potency of d-Tc and vecuronium was very different from that of metocurine, pancuronium or alcuronium. The action of d-Tc and vecuronium was potentiated in acidosis and antagonized in alkalosis. In contrast, that of metocurine, pancuronium or alcuronium was antagonized in acidosis and potentiated in alkalosis. The above finding suggests that a difference exists between mono- and bisquaternary MR with regard to the response to pH changes.
en-copyright=
kn-copyright=

en-aut-name=OnoKazumi
en-aut-sei=Ono
en-aut-mei=Kazumi
kn-aut-name=小野和身
kn-aut-sei=小野
kn-aut-mei=和身
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔・蘇生学教室
en-keyword=非脱分極性筋弛緩薬
kn-keyword=非脱分極性筋弛緩薬
en-keyword=ｐH
kn-keyword=ｐH
en-keyword=筋弛緩作用
kn-keyword=筋弛緩作用
END

start-ver=1.4
cd-journal=joma
no-vol=97
cd-vols=
no-issue=7-8
article-no=
start-page=567
end-page=572
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1985
dt-pub=19850830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Classification of fecal streptococci isolated from river water
kn-title=河川水汚染指標としての糞便レンサ球菌の菌種分類
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The authors classified the streptococci isolated from river water. Three hundred ninety strains of cocci were isolated from river water and classified. Of them, 362 strains (93%) proved to be enterococci derived from human and cattle feces. Only 28 strains, 7% of the isolates, were identified as S. faecalis subsp. liquefaciens which can be thought to be derived from insects. The results indicate that the classification of fecal streptococci is a reliable and useful indicator of water pollution.
en-copyright=
kn-copyright=

en-aut-name=KoujimaIzumi
en-aut-sei=Koujima
en-aut-mei=Izumi
kn-aut-name=国府島泉
kn-aut-sei=国府島
kn-aut-mei=泉
aut-affil-num=1
ORCID=

en-aut-name=OnoKeiji
en-aut-sei=Ono
en-aut-mei=Keiji
kn-aut-name=小野敬治
kn-aut-sei=小野
kn-aut-mei=敬治
aut-affil-num=2
ORCID=

en-aut-name=MoriYasumi
en-aut-sei=Mori
en-aut-mei=Yasumi
kn-aut-name=森康巳
kn-aut-sei=森
kn-aut-mei=康巳
aut-affil-num=3
ORCID=

en-aut-name=KanemasaYasuhiro
en-aut-sei=Kanemasa
en-aut-mei=Yasuhiro
kn-aut-name=金政泰弘
kn-aut-sei=金政
kn-aut-mei=泰弘
aut-affil-num=4
ORCID=

en-aut-name=OkabeAkinobu
en-aut-sei=Okabe
en-aut-mei=Akinobu
kn-aut-name=岡部昭延
kn-aut-sei=岡部
kn-aut-mei=昭延
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=就実短期大学

affil-num=2
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=5
en-affil=
kn-affil=香川医科大学微生物学教室
en-keyword=Fecal streptococci
kn-keyword=Fecal streptococci
en-keyword=Enterococci
kn-keyword=Enterococci
en-keyword=Water pollution
kn-keyword=Water pollution
en-keyword=Biological indicator
kn-keyword=Biological indicator
END

start-ver=1.4
cd-journal=joma
no-vol=99
cd-vols=
no-issue=5-6
article-no=
start-page=559
end-page=567
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1987
dt-pub=19870630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on heparin in allergic reactions 3. Therapeutic use of heparin in bronchial asthma
kn-title=アレルギーにおけるheparinの役割に関する研究　第3編　気管支喘息におけるheparin療法
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Seventy-five patients with bronchial asthma were treated with heparin by three different administration methods : 5000 u intravenously plus 5000 u by inhalation (method 1), 5000 u intravenously plus 5000 u by inhalation combined with 1 mg sulbutamol (method 2) and 10000 u by inhalation (method 3). The percent efficacy of heparin therapy was 44.4 % in the bronchial asthma patients treated by method 1, 72.7% in those treated by method 2 and 25.0% in those treated by method 3. Heparin therapy was more effective in patients over 50 years old, those with an age at onset of 40 years or more (late onset asthma) and those with serum IgE levels of less than 400 u/ml. The efficacy of heparin was also observed more frequently in cases with lower FEV1.0%, (V50) and (V25) values. Reduction of the plasma heparin concentration 1 h after intravenous administration was more rapid in cases in which heparin was effective than in those in which it was not.
en-copyright=
kn-copyright=

en-aut-name=OnoHatsuko
en-aut-sei=Ono
en-aut-mei=Hatsuko
kn-aut-name=小野波津子
kn-aut-sei=小野
kn-aut-mei=波津子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2内科
en-keyword=気管支喘息
kn-keyword=気管支喘息
en-keyword=heparin
kn-keyword=heparin
en-keyword=喘息発作
kn-keyword=喘息発作
en-keyword=肺機能
kn-keyword=肺機能
END

start-ver=1.4
cd-journal=joma
no-vol=99
cd-vols=
no-issue=5-6
article-no=
start-page=547
end-page=557
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1987
dt-pub=19870630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on heparin in allergic reactions 2. Plasma concentration of heparin in bronchial asthma
kn-title=アレルギーにおけるheparinの役割に関する研究　第2編　気管支喘息における血漿heparinに関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To observe the participation of heparin in asthma attacks, plasma concentrations of heparin were estimated in asthmatic subjects. Changes in the plasma concentration of heparin after intravenous administration were also examined during asthma attacks. The mean plasma concentration of heparin was 0.017u/5ml in healthy subjects, and 0.017u/5ml in the non-attack stage, 0.018u/5ml in the pre-attack stage and 0.016u/5ml in the attack stage of bronchial asthma patients. The plasma concentration of heparin in the mild cases of asthma was higher in the attack-free period than in the attack period, while the plasma concentration of heparin in the severe cases of asthma was significantly lower in the attack-free period than in the attack period. There was a significant correlation between the plasma concentration of heparin and the peripheral basophil count. The time-dependent reduction in plasma heparin after intravenous administration was more remarkable in asthmatic subjects than in healthy subjects, and the reduction was most remarkable in the large attack stage of asthma. The half-reduction time of the plasma heparin concentration after intravenous administration was 1h and 20min.
en-copyright=
kn-copyright=

en-aut-name=OnoHatsuko
en-aut-sei=Ono
en-aut-mei=Hatsuko
kn-aut-name=小野波津子
kn-aut-sei=小野
kn-aut-mei=波津子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2内科
en-keyword=気管支喘息
kn-keyword=気管支喘息
en-keyword=heparin
kn-keyword=heparin
en-keyword=heparin代謝
kn-keyword=heparin代謝
en-keyword=健康人
kn-keyword=健康人
END

start-ver=1.4
cd-journal=joma
no-vol=99
cd-vols=
no-issue=5-6
article-no=
start-page=537
end-page=546
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1987
dt-pub=19870630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on heparin in allergic reactions 1. Action of heparin on immediate hypersensitivity
kn-title=アレルギーにおけるheparinの役割に関する研究　第1編　即時型アレルギー反応におけるheparinの作用機序に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The action of heparin on allergic reactions was examined in skin and bronchial reactions to chemical mediators, in the rat PCA reaction and antigen-induced degranulation of rat peritoneal mast cells. Heparin inhibited the histamine-induced skin reaction in rats. Bronchoconstriction caused by histamine and acetylcholine was also inhibited by pre-treatment with heparin. The skin reaction due to reaginic antibody (PCA), but not that due to precipitated antibody, in rats was inhibited by heparin administration. Heparin moderately inhibited the degranulation of rat peritoneal mast cells elicited by reaginic antibody, but the inhibitory action was not as strong as that of prednisolone or disodiumcromoglycate.
en-copyright=
kn-copyright=

en-aut-name=OnoHatsuko
en-aut-sei=Ono
en-aut-mei=Hatsuko
kn-aut-name=小野波津子
kn-aut-sei=小野
kn-aut-mei=波津子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2内科
en-keyword=heparin
kn-keyword=heparin
en-keyword=reagin様抗体
kn-keyword=reagin様抗体
en-keyword=皮内反応
kn-keyword=皮内反応
en-keyword=化学伝達物質
kn-keyword=化学伝達物質
en-keyword=肥満細胞
kn-keyword=肥満細胞
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=
article-no=
start-page=24
end-page=50
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1952
dt-pub=195211
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=STUDIES OF THE RADIO-ACTIVE SPRINGS (XXXII) EFFECTS OF THE RADIO-ACTIVE THERMAL BATH ON CIRCULATION SYSTEM (2nd Report)
kn-title=放射能泉に関する研究(XXXII) 放射能泉入浴の循環器に及ぼす影響（第2報）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=a)The author studied the changes in the activity of choline'-esterase (ChE) in serum, before and after a radio-active thermal bath (43℃,5min.)in　Misasa,　and their seasonal differences. The results were as follows: (1) The ChE activity in human serum was stronger in winter than in summer. (2) The ChE activity was reduced after the thermal bath, and the decrease was more marked in winter than in summer. b) The author proved by Laewen-Trendelenburg's method that fresh radio-active thermal water of "Yamada-Ku-Kyodo-Yu" in Misasa dilatates the blood-vessel, but the same water, stored for weeks, constricts the vessel. Under the author's experimental conditions the dilatating effect of the radio-active spring waters proved to become stronger as their radon content increases. The freshly taken Yamada-Yu water inhihited the action of Adrenaline or Imidaline (a benzyl-imidazoline derivate), but the aged Yamada-Yu water showed no such antagonistic action. c) Blood circulation time, measured with vitamine B(1), was reduced after the thermal bath, but the changes showed no significant difference between the radio-active thermal bath and plain water bath. d) The height of waves of the electrocardiograms in healthy persons increased more after
the radio-active thermal bath than after the plain water bath in general. The increase was higher as the temperature of bath rises, but the difference between the kinds of baths was not significant. In chronic rheumatism and hypertension patients the increase was slight, and in some cases a remarkable fall of ST was recognized after the radio-active thermal bath at 40℃ for 10 minutes. QRS shortened slightly in Wilson's lead. After a bath at 40℃ for 10min., lowering of the minimal blood pressure was not so marked than after a bath at 43℃ for 5min., both in healthy and diseased persons.
en-copyright=
kn-copyright=

en-aut-name=OnodaSusumu
en-aut-sei=Onoda
en-aut-mei=Susumu
kn-aut-name=小野田進
kn-aut-sei=小野田
kn-aut-mei=進
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学温泉研究所内科
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=23
end-page=39
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1951
dt-pub=195103
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=STUDIES OF THE RAD10-ACTIVE SPRINGS (XXVIII). EFFECTS OF THE RADIO-ACTIVE THERMAL BATH ON CIRCULATION SYSTEM (1).
kn-title=放射能泉に関する研究(XXVIII) 放射能泉入浴の循環器に及ぼす影響 (第1報)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author investigated the changes in skin temperature, oral temperature, blood pressure, pulse rate, respiration rate and weight of body before and after a radio-active thermal bath in Misaswa, and compared the results with the corresponding changes after a plain water bath at a same temperature (43℃) with same duration (5min.). A rise in skin temperature after the thermal bath durated longer than after the control plain water bath. Changes in oral temperature did not correspond to the changes in skin temperature and to the suhjective warm feeling. Changes in the pulse pressure showed no significant difference between the radio-active thermal bath and plain water hath. But a more prolonged lowering of the minimal blood pressure was proved after a radio-active thermal bath than
after a plain water bath at same temperature with same duration. The response in blood pressure to thermal bath was more marked in winter than in summer. A rise in pulse rate was recognized after all kinds of hot baths, but no difference was proved between them. A slight acceleration of respiration rate and a loss in weight were observed after hot bath at 43℃ for 5 minutes. But these effects were slighter after radio-active thermal bath than after plain water bath at same temperature and same duration.
en-copyright=
kn-copyright=

en-aut-name=OnodaSusumu
en-aut-sei=Onoda
en-aut-mei=Susumu
kn-aut-name=小野田進
kn-aut-sei=小野田
kn-aut-mei=進
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大學放射能泉研究所
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=1
article-no=
start-page=27
end-page=36
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2001
dt-pub=20011225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Attempts to create the amenity from the nursing point of view - Through approach by using the wrapping skills -
kn-title=看護の視点からのアメニティ創出への試み ―ラッピング技法を用いてのアプローチから―
en-subtitle=
kn-subtitle=
en-abstract=The importance of producing the comfortable environment, namely to create the amenity for the patients admitted in the hospitals, has been recognized recently. In this study, to create the better amenity for admitted patients' daily life by the nurses, we examined the influence of the ways of displaying, placing and decorating the daily materials, such as booklets, tea cups, letters and etc. on a bed side table, using the wrapping skills. As a result, we found out that creating the amenity using the wrapping skills might be useful for the admitted patients' care and their mental healing. Furthermore, we indicated some important points when using the wrapping skills, such as selecting appropriate materials and methods suiting for each subjected matter.
kn-abstract=病院におけるアメニティの重要性は十数年前から言われているが,それは建物の建築の時だけでなく,その後療養の場所をどのように維持し,快適環境を患者にいつまでも提供していくかである｡これまで日常の看護業務において掲示物やパンフレットの置き方,床頭台のあり方などは整理整頓の一環で病棟管理の中にあった｡だが,もう一つの流れがある｡ウイリアム・モリスは生活の中における芸術化を考え,生活用品そのものに美しきと手作りの良さがあることを提唱した｡こうした生活デザインの流れの中で,本研究では本学科棟内において床頭台のディスプレイや掲示の仕方,パンフレットの置き方など,ラッピング技法を使用し,入院生活上のアメニティの創出を試みた｡その後,ラッピング技法を用いたアメニティ創出の試みは患者の心を癒す可能性のあることを明らかにした｡また,ラッピング技法使用上の留意点についても指摘した｡
en-copyright=
kn-copyright=

en-aut-name=OnoKiyomi
en-aut-sei=Ono
en-aut-mei=Kiyomi
kn-aut-name=小野清美
kn-aut-sei=小野
kn-aut-mei=清美
aut-affil-num=1
ORCID=

en-aut-name=HayashiYuko
en-aut-sei=Hayashi
en-aut-mei=Yuko
kn-aut-name=林優子
kn-aut-sei=林
kn-aut-mei=優子
aut-affil-num=2
ORCID=

en-aut-name=OhiNobuko
en-aut-sei=Ohi
en-aut-mei=Nobuko
kn-aut-name=大井伸子
kn-aut-sei=大井
kn-aut-mei=伸子
aut-affil-num=3
ORCID=

en-aut-name=OkudaHiroyuki
en-aut-sei=Okuda
en-aut-mei=Hiroyuki
kn-aut-name=奥田博之
kn-aut-sei=奥田
kn-aut-mei=博之
aut-affil-num=4
ORCID=

en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部保健学科看護学専攻

affil-num=2
en-affil=
kn-affil=岡山大学医学部保健学科看護学専攻

affil-num=3
en-affil=
kn-affil=岡山大学医学部保健学科看護学専攻

affil-num=4
en-affil=
kn-affil=岡山大学医学部保健学科看護学専攻

affil-num=5
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
en-keyword=アメニティ (amenity)
kn-keyword=アメニティ (amenity)
en-keyword=ラッピング (wrapping skill)
kn-keyword=ラッピング (wrapping skill)
en-keyword=入院生活 (life in hospital)
kn-keyword=入院生活 (life in hospital)
en-keyword=色彩 (color)
kn-keyword=色彩 (color)
en-keyword=癒し (care healing)
kn-keyword=癒し (care healing)
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=1
article-no=
start-page=37
end-page=45
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20021225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Color environment of maternity centers - Visual measurements of consultation and waiting room areas -
kn-title=助産所における色彩環境に関する検討 ―診察室および玄関兼待合室の視感測定を実施して―
en-subtitle=
kn-subtitle=
en-abstract=Color has not been focused on in the management of maternity centers, but is a factor that can help to establish a good environment. Therefore, we carried out a
visual assessment of the color environment in the consultating room and hall/waiting room of M Maternity Center. It was found that the center used the colors of sofa covers, foliage plants, and artificial flowers effectively and that the colors of dolls and backless slippers were bright. In addition, large posters strongly
influenced the ambient color environment. Consequently, the following seven items should be considered in the production of a good color environment. 1) Effective utilization of foliage plants. 2) Correct choice of materials as well as colors for carpets and sofas in order to give a good feeling to patients via color changes. 3) Maintenance of color regularity of the space by preventing color scattering. 4) Consideration should be given to children's views in color planning when the objects are to be used by children. 5) Active utilization of artificial flowers to produce a stress-relieving environment. 6) Correct choice of location for posters by considering the influence of their colors when large posters are hung. 7) Consideration of the shade, rather than the hue, of the color in the consulting room so that patients feel "calm", "peace" and "stress-relieving warmth".
kn-abstract=これまで助産所管理に関する事柄において色彩環境についてあまり触れられてこなかったが,色彩環境はよい環境を作りだすことができる要素である｡そこで､M助産院の診察室および玄関兼待合室の色彩環境の視感測定を実施した｡M事例でわかったことは,ソファカバーや観葉植物･造花などの有効な活用を図っていたが,人形やスリッパなどの小物は目立つ色彩であった｡また,大きなポスターは周囲の色彩環境を左右していた｡以上のことから,今後,よい色彩環境にするために留意すべき点は以下の7項目である｡ 1)観葉植物の有意義な活用をすること｡ 2)カーペットやソファーカバーなどで色彩変化を楽しめるが､その素材にも留意すること｡ 3)色彩の散乱を防止し,空間内の色彩秩序を保つこと｡ 4)子どもなどを対象にした物の場合には,対象者の視線にあわせた色彩計画をすること｡ 5)癒しの環境作りに造花は手軽に利用できる｡ 6)大きなポスターを貼る時には､その色彩の影響を考慮し添付場所を選択すること｡ 7)診療場所の色彩は色相より彩度には留意し,｢落ち着き｣｢おだやかさ｣｢ほっとする温かみ｣などを得られるような工夫をすること｡
en-copyright=
kn-copyright=

en-aut-name=OnoKiyomi
en-aut-sei=Ono
en-aut-mei=Kiyomi
kn-aut-name=小野清美
kn-aut-sei=小野
kn-aut-mei=清美
aut-affil-num=1
ORCID=

en-aut-name=OkudaHiroyuki
en-aut-sei=Okuda
en-aut-mei=Hiroyuki
kn-aut-name=奥田博之
kn-aut-sei=奥田
kn-aut-mei=博之
aut-affil-num=2
ORCID=

en-aut-name=MitsuokaMictiko
en-aut-sei=Mitsuoka
en-aut-mei=Mictiko
kn-aut-name=光岡美智子
kn-aut-sei=光岡
kn-aut-mei=美智子
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部保健学科

affil-num=2
en-affil=
kn-affil=岡山大学医学部保健学科

affil-num=3
en-affil=
kn-affil=光岡助産院
en-keyword=助産所 (maternity center)
kn-keyword=助産所 (maternity center)
en-keyword=色彩 (color)
kn-keyword=色彩 (color)
en-keyword=アメニティ (amenity)
kn-keyword=アメニティ (amenity)
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=1
article-no=
start-page=17
end-page=24
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20021225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Nursing Care Workers' Concerns about Child Restraint System
kn-title=チャイルドシートに関する看護職の意識調査
en-subtitle=
kn-subtitle=
en-abstract=This study surveyed nursing care workers (workers) understandings of regulations regarding the emergent transportation of childhood patients and child restraint
systems (CRS). It also ascertained how they addressed issues involved in the transportation of children by car. Subjects were 725 workers at hospitals or health centers in Okayama City, who were sent an anonymous style questionnaire that was then retrieved by mail (recovery rate 72.2%). As the results, 84.6% of workers had never discussed childhood patient transportation during admission/discharge, with most not being involved in the transportation of children. Only 40.9% answered correctly to 5 questions regarding the exclusive provisions of
CRS used to ascertain understanding of the regulations. There were two responses regarding "CRS application to fat children or those with mental restlessness": some encouraged the parents to make a decision and others took advices from doctors. A driver was held responsible for a car accident in Japan when a healthy child was transported without CRS. No case regarding the exclusive provisions has yet been reported. In cases of car accidents, drivers will from now surely be held responsible for the use of CRS. This survey provided nursing care workers for the opportunity to recognize the importance of CRS in the emergenty transportation of children.
kn-abstract=本調査は患児の救急搬送時のことやCRS (child restraint system)における法規制の理解などに対する看護職の意識と子どもの車での搬送に関する問題への対応を知る目的で実施した｡岡山市内にある病院および保健所･保健センターに勤務している看護職725名(回収率72.2%)を対象に無記名アンケート方式で郵送法にて実施した｡その結果,入退院時の搬送については｢一度も話したことがない者｣は84.6%で,搬送に関してはほとんど関与していなかった｡CRSの除外規定に関する法的理解について5項目質問したが､正解者は40.9%であった｡その他"肥満児および精神的な不穏時のCRSの対応"として
は保護者への判断を促す者と医師の判断を仰ぐ者との2通りの意見があった｡
わが国では健常児の非CRS使用時の搬送時に事故がおき運転者責任を問われたが,除外規定に関する判例ではなかった｡今後は交通事故の発生の場合には確実にCRSの問題は運転者の判断を問われることになる｡看護職としては子どもの搬送にCRSは関与していることを認識することへの示唆となるだろう｡
en-copyright=
kn-copyright=

en-aut-name=OnoKiyomi
en-aut-sei=Ono
en-aut-mei=Kiyomi
kn-aut-name=小野清美
kn-aut-sei=小野
kn-aut-mei=清美
aut-affil-num=1
ORCID=

en-aut-name=SumiyoshiKazuko
en-aut-sei=Sumiyoshi
en-aut-mei=Kazuko
kn-aut-name=住吉和子
kn-aut-sei=住吉
kn-aut-mei=和子
aut-affil-num=2
ORCID=

en-aut-name=OkazakiYuka
en-aut-sei=Okazaki
en-aut-mei=Yuka
kn-aut-name=岡崎愉加
kn-aut-sei=岡崎
kn-aut-mei=愉加
aut-affil-num=3
ORCID=

en-aut-name=OhtaTakeo
en-aut-sei=Ohta
en-aut-mei=Takeo
kn-aut-name=太田武夫
kn-aut-sei=太田
kn-aut-mei=武夫
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部保健学科

affil-num=2
en-affil=
kn-affil=岡山大学医学部保健学科

affil-num=3
en-affil=
kn-affil=岡山大学医学部保健学科

affil-num=4
en-affil=
kn-affil=岡山大学医学部保健学科
en-keyword=チャイルドシート (child restraint system)
kn-keyword=チャイルドシート (child restraint system)
en-keyword=看護職 (nursing care worker)
kn-keyword=看護職 (nursing care worker)
en-keyword=子どもの搬送 (child transportation)
kn-keyword=子どもの搬送 (child transportation)
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=1
article-no=
start-page=65
end-page=73
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20031225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=First year students' understanding of the relationship between the
kn-title=｢助産学総論｣と看護系の実習との関連における理解度に関する一考察 ―O大学保健学科看護学専攻･助産師コース第一期生の場合―
en-subtitle=
kn-subtitle=
en-abstract=The "fundamentals of midwifery" is one of the most basic subjects in the education of midwives, but only 30 hours of lectures are given in this subject. To have students approach the subject as a professional one, numerous elements including current problems faced by women and problems between women and their partners need to be presented in the limited hours. In doing this, it is important not only to give lectures, but also to instill recognition of the relationship of the lectures to nursing. community and midwifery practices. Students filled out questionnaires to evaluate the lectures and to indicate their level of understanding of midwifery practice. From the results, the students' levels of understanding of the contents of the "fundamentals of midwifery" were investigated and classified into: 1) what needs to be understood from the "fundamentals of midwifery" lectures, 2) what can be understood in relation to midwifery practice, and 3) what can be understood through other practice.
kn-abstract=助産学総論は助産師の基礎教育において最も基本となる教科であるが,講義時間は30時間と限られた中で近年の女性やパートナーとの問題を含め,専門職として学修させるためには膨大な内容を示唆していかなければならない｡それには講義のみでなく看護学実習,地域実習,助産学実習などとの関連も把握しながら,これを遂行していくことは重要である｡講義および助産学実習について講義評価アンケートや実習理解度アンケートなどから助産学総論の内容への理解度を検討した｡検討結果,助産学総論の講義内容においてわかったことは,｢助産学総論の講義で理解させなければならないこと｣,｢助産学実習と関連して理解させられること｣,｢助産学実習以外の他の実習でも理解させられること｣などの内容を選別することができた｡
en-copyright=
kn-copyright=

en-aut-name=OnoKiyomi
en-aut-sei=Ono
en-aut-mei=Kiyomi
kn-aut-name=小野清美
kn-aut-sei=小野
kn-aut-mei=清美
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部保健学科看護学専攻
en-keyword=助産学 (Midwifery)
kn-keyword=助産学 (Midwifery)
en-keyword=助産学実習 (Midwifery practice)
kn-keyword=助産学実習 (Midwifery practice)
en-keyword=看護学実習 (nursing practice)
kn-keyword=看護学実習 (nursing practice)
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=1
article-no=
start-page=57
end-page=64
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20031225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Provision of information and health care in a maternity ward: More effective use of corridor notice boards
kn-title=産科病棟における保健サービスと情報提供に関する一考察―廊下にある掲示板の工夫をして―
en-subtitle=
kn-subtitle=
en-abstract=Although bulletin boards in hospitals are considered a readily accessible means of information sharing, there are virtually no studies available on this subject. However, as a self-assessment survey of the Japan Council for Quality Health Care includes a rating of "attention given to posted materials" as one of its items, we thus conducted a study focused on the bulletin board situated in the corridor of O University Hospital's maternity ward. After measuring color visibility and lighting intensity around the board, we reorganized the layout of posted materials; after which we evaluated the appearance of the board using the Semantic Differential Method. The results were positive; and in addition, we conducted other surveys
intended to obtain comments and requests. As a result of such efforts, we came up with two criteria to consider when designing a bulletin board; namely, on how to use bulletin boards effectively and on classifying the type of announcement. <On the Effective Use of Bulletin Boards>
1. Arrange display materials according to importance and urgency levels 2. Use font sizes and drawings as eye-catching means <On the Classification of the Type of Announcement> 1. There is a need to provide patient education and health information related to the field of obstetrics. 2. There is a need to clearly identify the targets, i.e. whether the posted materials are intended for the patients and/or for family members. 3. There is also a need to provide general news or to post drawings and pictures for the purpose of comforting patients.
kn-abstract=病棟における情報提供の一つとして掲示板は手軽に利用されるが,これに関する研究はないといっても過言ではない｡しかし,日本医療機能評価機構(Japan Council for Quality Health Care)においては自己評価票の項目として｢掲示物の配慮｣について評価するようになっている｡そこで,O大学附属病院産科病棟の廊下にある掲示板を使用し,掲示板周辺の色彩の視感測定と照度測定を実施し後,掲示物の内容の整理をし,その美観について整理前後の評価をSD法(Semantic Diferenial Method)で評価しその結果,
整理後は好転していた｡さらに,掲示物への意見の調査,希望する掲示内容に関する調査なども実施した｡これらのことから掲示板の有効活用の仕方と情報提供の内容の選別の2点が明確化した｡それぞれの留意点は以下のとおりである｡<有効活用について>1.掲示物の重要度と緊急性に応じた貼り方をする｡2.文字や絵の大きさにより,掲示板の有効活用をする｡<情報提供の内容の選別について>1.産科領域の患者教育および健康教育などの提供の必要性がある｡2.掲示物の内容は患者本人に必要なことか,家族にも必要なことなのか,対象者の明確化をして貼付する必要がある｡3.一般ニュースの提供や絵や写真などの癒しの必要性もある。
en-copyright=
kn-copyright=

en-aut-name=OnoKiyomi
en-aut-sei=Ono
en-aut-mei=Kiyomi
kn-aut-name=小野清美
kn-aut-sei=小野
kn-aut-mei=清美
aut-affil-num=1
ORCID=

en-aut-name=OkudaHiroyuki
en-aut-sei=Okuda
en-aut-mei=Hiroyuki
kn-aut-name=奥田博之
kn-aut-sei=奥田
kn-aut-mei=博之
aut-affil-num=2
ORCID=

en-aut-name=MatsuiTamiko
en-aut-sei=Matsui
en-aut-mei=Tamiko
kn-aut-name=松井たみこ
kn-aut-sei=松井
kn-aut-mei=たみこ
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部保健学科看護学専攻

affil-num=2
en-affil=
kn-affil=岡山大学医学部保健学科看護学専攻

affil-num=3
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院
en-keyword=情報提供 (information service)
kn-keyword=情報提供 (information service)
en-keyword=サービス (health care)
kn-keyword=サービス (health care)
en-keyword=産科病棟 (maternity ward)
kn-keyword=産科病棟 (maternity ward)
END

start-ver=1.4
cd-journal=joma
no-vol=27
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=19
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090326
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=An Introduction to the Study on the Shokuiku System in School
kn-title=学校における食育に関する制度的考察序説
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野尚美
kn-aut-sei=小野
kn-aut-mei=尚美
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=121
cd-vols=
no-issue=1
article-no=
start-page=17
end-page=24
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Two cases of mandibular and masticatory reconstruction with vascularized fibra bone flaps and implants
kn-title=血管柄付腓骨皮弁移植とインプラントによる顎骨咬合再建の２例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　Defects of the jawbone have conventionally been repaired using free bone grafts and metallic plates, but patients undergoing reconstruction using these materials experience difficulty using dentures and restoring masticatory function. The use of vascularized bone grafts, which has recently been enabled, has improved bone graft survival rates, and its combination with dental implants has enabled both morphological and functional reconstruction, leading to a higher quality of life.
　We experienced two patients with tumors of the jaw that were treated by resecting and reconstructing it using a vascularized bone graft with the cooperation of the Department of Plastic Surgery in the School of Medicine. We subsequently inserted dental implants, and the superstructure was created by the Department of Prosthetics. We report the course of these patients, who achieved sufficient jaw morphology as well as masticatory function and who are presently satisfied overall three years to three years and nine months postoperatively.
en-copyright=
kn-copyright=

en-aut-name=TakagiShin
en-aut-sei=Takagi
en-aut-mei=Shin
kn-aut-name=高木愼
kn-aut-sei=高木
kn-aut-mei=愼
aut-affil-num=1
ORCID=

en-aut-name=MizukawaNobuyoshi
en-aut-sei=Mizukawa
en-aut-mei=Nobuyoshi
kn-aut-name=水川展吉
kn-aut-sei=水川
kn-aut-mei=展吉
aut-affil-num=2
ORCID=

en-aut-name=FukunagaJoji
en-aut-sei=Fukunaga
en-aut-mei=Joji
kn-aut-name=福永城司
kn-aut-sei=福永
kn-aut-mei=城司
aut-affil-num=3
ORCID=

en-aut-name=IshidaNobuhisa
en-aut-sei=Ishida
en-aut-mei=Nobuhisa
kn-aut-name=石田展久
kn-aut-sei=石田
kn-aut-mei=展久
aut-affil-num=4
ORCID=

en-aut-name=MaruoYukinori
en-aut-sei=Maruo
en-aut-mei=Yukinori
kn-aut-name=丸尾幸憲
kn-aut-sei=丸尾
kn-aut-mei=幸憲
aut-affil-num=5
ORCID=

en-aut-name=KannyamaManabu
en-aut-sei=Kannyama
en-aut-mei=Manabu
kn-aut-name=完山学
kn-aut-sei=完山
kn-aut-mei=学
aut-affil-num=6
ORCID=

en-aut-name=KimataYoshihiro
en-aut-sei=Kimata
en-aut-mei=Yoshihiro
kn-aut-name=木股啓裕
kn-aut-sei=木股
kn-aut-mei=啓裕
aut-affil-num=7
ORCID=

en-aut-name=KoushimaIsao
en-aut-sei=Koushima
en-aut-mei=Isao
kn-aut-name=光嶋勲
kn-aut-sei=光嶋
kn-aut-mei=勲
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬総合研究科　顎口腔再建外科学

affil-num=2
en-affil=
kn-affil=岡山大学医学部歯学部附属病院　口腔外科（再建系）

affil-num=3
en-affil=
kn-affil=姫路市

affil-num=4
en-affil=
kn-affil=岡山大学医学部歯学部附属病院　口腔外科（再建系）

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬総合研究科　咬合・有床義歯補綴学

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬総合研究科　インプラント再生補綴学

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬総合研究科　形成再建外科学

affil-num=8
en-affil=
kn-affil=東京大学大学院医学系研究科　感覚・運動機能医学
en-keyword=血管柄付骨移植　（vascularized bone graft）
kn-keyword=血管柄付骨移植　（vascularized bone graft）
en-keyword=顎骨再建　（mandibular reconstruction）
kn-keyword=顎骨再建　（mandibular reconstruction）
en-keyword=インプラント　（implant）
kn-keyword=インプラント　（implant）
en-keyword=咬合再建　（occlusal reconstruction）
kn-keyword=咬合再建　（occlusal reconstruction）
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=
article-no=
start-page=88
end-page=92
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20030201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of anti - neutrophil cytoplasmic autoantibody-associated vasculitis: Resolution after early diagnosis
kn-title=早期診断にて軽快したMPO-ANCA関連血管炎の一例
en-subtitle=
kn-subtitle=
en-abstract=A 76-year-old man was admitted to our hospital for pulmonary rehabilitation. Three years before admission he was diagnosed as pulmonary emphysema. On the day of admission the patient was febrile[37-38°C]. Initially lower respiratory infection was suspected and antibiotics
was given to the patient, but his fever sustained.
On admission he presented proteinuria and hematuria and the following examination revealed the high titer [307U/ml] of myeloperoxidase specific anti -neutrophil cytoplasmic
autoantibody (MPO-ANCA). A gradual rise in serum creatinine levels after admission was also observed. He was diagnosed as MPO-ANCA associated vasculitis. Prednisolone therapy was
started, which improved his symptoms and laboratory data rapidly.
kn-abstract=症例は76歳男性03年前肺気腫と診断された｡今回呼吸器リハビリテーション目的で当院に入院の運びとなった｡入院時より37-38'Cの発熱を認め,下気道感染を疑い抗生剤で加療したが改善しなかった.入院時の検尿検査で蛋白･潜血陽性であり,血清MPO-ANCAが307U/mlと高値を示した｡血清クレアチニン値も徐々に上昇してきたため,MPO-ANCA関連血管炎と診断した.プレドニゾロン投与を開始したところ,症状及び検査所見は速やかに改善した.
en-copyright=
kn-copyright=

en-aut-name=IchikawaHirohisa
en-aut-sei=Ichikawa
en-aut-mei=Hirohisa
kn-aut-name=市川裕久
kn-aut-sei=市川
kn-aut-mei=裕久
aut-affil-num=1
ORCID=

en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=芦田耕三
kn-aut-sei=芦田
kn-aut-mei=耕三
aut-affil-num=2
ORCID=

en-aut-name=OnoKatsuichiro
en-aut-sei=Ono
en-aut-mei=Katsuichiro
kn-aut-name=小野勝一郎
kn-aut-sei=小野
kn-aut-mei=勝一郎
aut-affil-num=3
ORCID=

en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=高田真吾
kn-aut-sei=高田
kn-aut-mei=真吾
aut-affil-num=4
ORCID=

en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
en-aut-mei=Tadashi
kn-aut-name=横井正
kn-aut-sei=横井
kn-aut-mei=正
aut-affil-num=5
ORCID=

en-aut-name=NagataTakuya
en-aut-sei=Nagata
en-aut-mei=Takuya
kn-aut-name=永田拓也
kn-aut-sei=永田
kn-aut-mei=拓也
aut-affil-num=6
ORCID=

en-aut-name=OkamotoMakoto
en-aut-sei=Okamoto
en-aut-mei=Makoto
kn-aut-name=岡本誠
kn-aut-sei=岡本
kn-aut-mei=誠
aut-affil-num=7
ORCID=

en-aut-name=TsugenoHirohumi
en-aut-sei=Tsugeno
en-aut-mei=Hirohumi
kn-aut-name=柘野浩史
kn-aut-sei=柘野
kn-aut-mei=浩史
aut-affil-num=8
ORCID=

en-aut-name=NishidaNorikazu
en-aut-sei=Nishida
en-aut-mei=Norikazu
kn-aut-name=西田典数
kn-aut-sei=西田
kn-aut-mei=典数
aut-affil-num=9
ORCID=

en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=保﨑泰弘
kn-aut-sei=保﨑
kn-aut-mei=泰弘
aut-affil-num=10
ORCID=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=光延文裕
kn-aut-sei=光延
kn-aut-mei=文裕
aut-affil-num=11
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=谷崎勝朗
kn-aut-sei=谷崎
kn-aut-mei=勝朗
aut-affil-num=12
ORCID=

en-aut-name=NoguchiYoshinori
en-aut-sei=Noguchi
en-aut-mei=Yoshinori
kn-aut-name=野口菩範
kn-aut-sei=野口
kn-aut-mei=菩範
aut-affil-num=13
ORCID=

en-aut-name=TanimotoMitsune
en-aut-sei=Tanimoto
en-aut-mei=Mitsune
kn-aut-name=谷本光音
kn-aut-sei=谷本
kn-aut-mei=光音
aut-affil-num=14
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部附属病院三朝医療センター

affil-num=2
en-affil=
kn-affil=岡山大学医学部附属病院三朝医療センター

affil-num=3
en-affil=
kn-affil=岡山大学医学部附属病院三朝医療センター

affil-num=4
en-affil=
kn-affil=岡山大学医学部附属病院三朝医療センター

affil-num=5
en-affil=
kn-affil=岡山大学医学部附属病院三朝医療センター

affil-num=6
en-affil=
kn-affil=岡山大学医学部附属病院三朝医療センター

affil-num=7
en-affil=
kn-affil=岡山大学医学部附属病院三朝医療センター

affil-num=8
en-affil=
kn-affil=岡山大学医学部附属病院三朝医療センター

affil-num=9
en-affil=
kn-affil=岡山大学医学部附属病院三朝医療センター

affil-num=10
en-affil=
kn-affil=岡山大学医学部附属病院三朝医療センター

affil-num=11
en-affil=
kn-affil=岡山大学医学部附属病院三朝医療センター

affil-num=12
en-affil=
kn-affil=岡山大学医学部附属病院三朝医療センター

affil-num=13
en-affil=
kn-affil=鳥取県中部医師会立三朝温泉病院内科

affil-num=14
en-affil=
kn-affil=岡山大学大学院医歯学総合研究科血液･腫癌･呼吸器内科学
en-keyword=ANCA関連血管炎
kn-keyword=ANCA関連血管炎
en-keyword=早期診断
kn-keyword=早期診断
en-keyword=顕微鏡的多発血管炎
kn-keyword=顕微鏡的多発血管炎
END

start-ver=1.4
cd-journal=joma
no-vol=27
cd-vols=
no-issue=
article-no=
start-page=11
end-page=16
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=200512
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Basic study on the effects of the archeological investigation and the construction work
on the environmental radiation
kn-title=埋蔵文化財発掘調査および建設工事が環境放射線に及ぼす影響に関する基礎的検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper, we investigated how the excavation of ruins and the construction work affected the environmental radiation in the Shikata campus of Okayama University (S-campus). The environmental radiation was steady in the S-campus until 1997, but began to change since 1998, while the ruin's survey and the construction work started frequently after 1998 in the S-campus. In general, the soil and the concrete include the natural radioisotope (uranium series and thorium series, etc). When ruins are surveyed, it is necessary to move a large amount of the soil. In addition, a large amount of the concrete is used for the construction work. To measure the environmental radiation, the monitor posts were set up on the east and west sides of the building of the Radioisotope Center (RIC). We sampled the soil in the container in each place. We used the high-purity germanium detector to analyze them. The monitor posts showed the difference in the in-air dose rate in each place in the S-campus. The in-air dose rate at the east side of the RIC was higher than that at the west side. The result of analysis showed that the soil includes the (40)K at the east side. While the specific activity of the 40K was 0.849Bq/g at the east side, the (40)K was hardly detected in the soil at the west side. The each soil included the 214-lead and 214-bismus ((214)Pb, (214)Bi), however, there was no significant difference in the specific activity of the each soil. The concrete included (40)K, whose specific activity was 0.492Bq/g. It was suggested that the change of the environmental radiation was attributed to radon and its daughter nuclides in the soil rather than the radiation from the concrete in the buildings.
en-copyright=
kn-copyright=

en-aut-name=NagamatsuTomohiro
en-aut-sei=Nagamatsu
en-aut-mei=Tomohiro
kn-aut-name=永松知洋
kn-aut-sei=永松
kn-aut-mei=知洋
aut-affil-num=1
ORCID=

en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=花元克巳
kn-aut-sei=花元
kn-aut-mei=克巳
aut-affil-num=2
ORCID=

en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=小野俊朗
kn-aut-sei=小野
kn-aut-mei=俊朗
aut-affil-num=3
ORCID=

en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学自然生命科学研究支援センター

affil-num=2
en-affil=
kn-affil=岡山大学医学部

affil-num=3
en-affil=
kn-affil=岡山大学自然生命科学研究支援センター

affil-num=4
en-affil=
kn-affil=岡山大学医学部
en-keyword=archeological investigation
kn-keyword=archeological investigation
en-keyword=construction work
kn-keyword=construction work
en-keyword=environmental radiation
kn-keyword=environmental radiation
en-keyword=soil
kn-keyword=soil
en-keyword=concrete
kn-keyword=concrete
END

start-ver=1.4
cd-journal=joma
no-vol=30
cd-vols=
no-issue=
article-no=
start-page=33
end-page=37
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200812
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=岡山大学における核燃料物質の安全管理のための劣化ウランと天然ウランの鑑別について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In Japan, the Law for the Regulation of Nuclear Source Materials, Nuclear Fuel Materials and Reactors (Regulation Law) controls the nuclear fuel materials such as thorium (Th), uranium (U) and plutonium (Pu). Under the Regulation Law, all related materials and reactors are needed to register to the Government. In Okayama University, many nuclear fuel materials, mainly uranium compounds, are registered and stored in 11 departments, separately. Discrimination between depleted uranium and natural uranium is important for the observance of the Regulation Law and the safety management of the nuclear fuel materials in the Okayama University. However, the discrimination of the two kind of uranium has poorly analyzed. In this study, we analyzed several uranium compounds by using γ-ray spectrometry to determine whether the depleted uranium or not.
en-copyright=
kn-copyright=

en-aut-name=NagamatsuTomohiro
en-aut-sei=Nagamatsu
en-aut-mei=Tomohiro
kn-aut-name=永松知洋
kn-aut-sei=永松
kn-aut-mei=知洋
aut-affil-num=1
ORCID=

en-aut-name=HanafusaTadashi
en-aut-sei=Hanafusa
en-aut-mei=Tadashi
kn-aut-name=花房直志
kn-aut-sei=花房
kn-aut-mei=直志
aut-affil-num=2
ORCID=

en-aut-name=KinnoIkuo
en-aut-sei=Kinno
en-aut-mei=Ikuo
kn-aut-name=金野郁雄
kn-aut-sei=金野
kn-aut-mei=郁雄
aut-affil-num=3
ORCID=

en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=迫田晃弘
kn-aut-sei=迫田
kn-aut-mei=晃弘
aut-affil-num=4
ORCID=

en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=花元克巳
kn-aut-sei=花元
kn-aut-mei=克巳
aut-affil-num=5
ORCID=

en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=6
ORCID=

en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=小野俊朗
kn-aut-sei=小野
kn-aut-mei=俊朗
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院保健学研究科

affil-num=2
en-affil=
kn-affil=岡山大学自然生命科学研究支援センター光・放射線情報解析部門鹿田施設

affil-num=3
en-affil=
kn-affil=岡山大学自然生命科学研究支援センター光・放射線情報解析部門鹿田施設

affil-num=4
en-affil=
kn-affil=岡山大学大学院保健学研究科

affil-num=5
en-affil=
kn-affil=岡山大学大学院保健学研究科

affil-num=6
en-affil=
kn-affil=岡山大学大学院保健学研究科

affil-num=7
en-affil=
kn-affil=岡山大学自然生命科学研究支援センター光・放射線情報解析部門鹿田施設
en-keyword=Nuclear Fuel Materials
kn-keyword=Nuclear Fuel Materials
en-keyword=Depleted Uranium
kn-keyword=Depleted Uranium
en-keyword=Natural Uranium
kn-keyword=Natural Uranium
en-keyword=γ-ray Spectrometry
kn-keyword=γ-ray Spectrometry
END

start-ver=1.4
cd-journal=joma
no-vol=102
cd-vols=
no-issue=1-2
article-no=
start-page=77
end-page=86
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1990
dt-pub=199002
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Changes of extravascular lung water after hepatic ischemia by Pringle's maneuver Part 2. In regard to the effect of clamping of the superior mesenteric artery or portofemoral vein bypass
kn-title=Pringle 法急性肝流入血行遮断の肺血管外水分量におよぼす影響　第2編　上腸間膜動脈遮断と門脈一体循環シャント造設の効果を中心として
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To elucidate the effect of portal congestion on pulmonary interstitial edema after temporary hepatic ischemia by Pringle's maneuver, extravascular lung water (EVLW) was experimentally measured using a modified double indicator dilution method before and after interruption of the hepatic blood flow follwing clamping of the superior meaenteric artery or portofemoral vein bypass. The following results were obtained. 1) Compred with clamping of the superior mesenteric artery, the portofemoral vein bypass reduced the increase of EVLW after temporay hepatic ischemia by Pringle's maneuver. 2) The increase in EVLW had a tendency to be influenced by the degree of metabolic acidosis and portal congestion. These findngs suggest that the portofemoral vein bypass is more effective in the prolongation of the safe period of temporary hepatic ischemia by Pringle's maneuver than clamping of the superior mesenteric artery.
en-copyright=
kn-copyright=

en-aut-name=YokoyamaNobuji
en-aut-sei=Yokoyama
en-aut-mei=Nobuji
kn-aut-name=横山伸二
kn-aut-sei=横山
kn-aut-mei=伸二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=Pringle 法急性肝流入血行遮断
kn-keyword=Pringle 法急性肝流入血行遮断
en-keyword=肺血管外水分量
kn-keyword=肺血管外水分量
en-keyword=上腸間膜動脈遮断
kn-keyword=上腸間膜動脈遮断
en-keyword=門脈一体循環シャント
kn-keyword=門脈一体循環シャント
END

start-ver=1.4
cd-journal=joma
no-vol=102
cd-vols=
no-issue=1-2
article-no=
start-page=63
end-page=76
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1990
dt-pub=199002
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Changes of extravascular lung water after hepatic ischemia by Pringle's maneuver Part 1. In regard to the increase of the extravascular lunh water and its cause
kn-title=Pringle 法急性肝流入血行遮断の肺血管外水分量におよぼす影響　第1編　肺血管外水分量の増加とその成因を中心として
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To elucidate the effect of total hepatic ischemia on pulmonary organs, extravascular lung water (EVLW) was experimentally measured using a modified double indicator dilution method before and after interruption of the hepatic blood flow using Pringle's maneuver. The follow-ing results were obtained : 1) EVLW was significantlly increased more than one hour after temporary total hepatic ischemia. 2) Temporary hypotension resulted in little increase of EVLW by removing and replacing some blood volume through the femoral artery. 3) Pumonary interstitial edema was histologically and maroscopically observed in the Pringle's maneuver group. 4) Marked metabolic acidosis and elevation of serum transaminase were revealed after temporary hepatic ischemia. These findings auggest that pulmonary interstitial edema may result from sfter temporary total hepatic ischemia by Pringle's maneuver and the changes of EVLW are caused by increased permeability due to liver injury, metabolic acidosis and portal congestion.
en-copyright=
kn-copyright=

en-aut-name=YokoyamaNobuji
en-aut-sei=Yokoyama
en-aut-mei=Nobuji
kn-aut-name=横山伸二
kn-aut-sei=横山
kn-aut-mei=伸二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=Pringle 法急性肝流入血行遮断
kn-keyword=Pringle 法急性肝流入血行遮断
en-keyword=肺血管外水分量
kn-keyword=肺血管外水分量
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1183
end-page=1191
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Radiographic studies on lumbar spines of steel plant workers in relation to the pathogenesis of low back pain
kn-title=製鉄所従業員における腰椎のX線学的研究―腰痛の発生とX線所見との関連について―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In recent years, incidence of low back pain (LBP) has been increasing. To clarify the relation between instability of the lumbar spine and LBP in heavy industry workers, radiographic findings were compared with a questionnaire on 2863 workers in a steel plant, as a preliminary study in 1986. In 214 males, 4-direction X-ray examinations of the lumbar vertebrae were obtained and the results were analyzed along with a questionnaire survey. The examined subjects were classified into three groups according to their complaints into : A ; LBP free, B ; LBP moderate, and C ; LBP severe. Degeneration chages of the facet joint, lumbar disc narrowing, angles between vertebrae, and lumbar lordosis were investigated on the X-ray film. In general, the higher the intensity of LBP, the more intervertebral angles at all levels of the lumbar spine and the more severe the degeneration. There was a statistically significant difference between the A and C group in the intervertebral angles at lower levels. Incidence of the lumbar disc narrowing differed between the two groups. The instabilitiy of lumbar spine was found in the C group. Low back pain in the heavy industry workers can be caused by anterior motion factors such as lumbar disc narrowing rather than posterior motion factors such as degeneration of the facet joint.
en-copyright=
kn-copyright=

en-aut-name=IwagawaMotoyuki
en-aut-sei=Iwagawa
en-aut-mei=Motoyuki
kn-aut-name=岩河基行
kn-aut-sei=岩河
kn-aut-mei=基行
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部整形外科学教室
en-keyword=Low back pain
kn-keyword=Low back pain
en-keyword=Radiographic study
kn-keyword=Radiographic study
en-keyword=Instability
kn-keyword=Instability
en-keyword=Facet joint
kn-keyword=Facet joint
en-keyword=Lumbar disc narrowing
kn-keyword=Lumbar disc narrowing
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1171
end-page=1176
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Tumor lysis syndrome after the effective chemotherapy in a patient with recurrence of colon cancer
kn-title=癌化学療法が奏効し Tumor Lysis Syndrome を呈した結腸癌再発症例の一例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A case of recurrence of colon cancer with marked tumor reduction after effective chemotherapy is reported. The patient was a 27-years-old female who was admitted to the 1st department of surgery because of a giant abdominal tumor. She had undergone surgery for cecal cancer 16 months before admission. Abdominal and pelvic CT-SCAN revealed a giant tumor (21×18cm) invading the rectum and uterus. Surgical cannulation was performed into bilateral internal iliac arteries, and anti-cancer drugs (5-FU : 5000mg, ADR : 40mg, CDDP : 200mg) were administered intraarterially. The occurrence of hyperkalemia and striking rises in LDH, CEA, CA19-9 after the chemotherapy strongly suggested the tumor lysis syndrome, which to our knowledge, has not been reported as a complication of the treatment of colon carcinoma.
en-copyright=
kn-copyright=

en-aut-name=InoguchiKazuhito
en-aut-sei=Inoguchi
en-aut-mei=Kazuhito
kn-aut-name=井口利仁
kn-aut-sei=井口
kn-aut-mei=利仁
aut-affil-num=1
ORCID=

en-aut-name=IwagakiHiromi
en-aut-sei=Iwagaki
en-aut-mei=Hiromi
kn-aut-name=岩垣博巳
kn-aut-sei=岩垣
kn-aut-mei=博巳
aut-affil-num=2
ORCID=

en-aut-name=HamanakaSohei
en-aut-sei=Hamanaka
en-aut-mei=Sohei
kn-aut-name=浜中荘平
kn-aut-sei=浜中
kn-aut-mei=荘平
aut-affil-num=3
ORCID=

en-aut-name=MoreiraLuis Fernando
en-aut-sei=Moreira
en-aut-mei=Luis Fernando
kn-aut-name=モレイラルイス・フエルナンド
kn-aut-sei=モレイラ
kn-aut-mei=ルイス・フエルナンド
aut-affil-num=4
ORCID=

en-aut-name=NanbaHiroshi
en-aut-sei=Nanba
en-aut-mei=Hiroshi
kn-aut-name=難波浩
kn-aut-sei=難波
kn-aut-mei=浩
aut-affil-num=5
ORCID=

en-aut-name=OkabayashiTakahiro
en-aut-sei=Okabayashi
en-aut-mei=Takahiro
kn-aut-name=岡林孝弘
kn-aut-sei=岡林
kn-aut-mei=孝弘
aut-affil-num=6
ORCID=

en-aut-name=HizutaAkio
en-aut-sei=Hizuta
en-aut-mei=Akio
kn-aut-name=日伝晶夫
kn-aut-sei=日伝
kn-aut-mei=晶夫
aut-affil-num=7
ORCID=

en-aut-name=OritaKunzo
en-aut-sei=Orita
en-aut-mei=Kunzo
kn-aut-name=折田薫三
kn-aut-sei=折田
kn-aut-mei=薫三
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=Tumor Lysis Syndrome
kn-keyword=Tumor Lysis Syndrome
en-keyword=結腸癌再発
kn-keyword=結腸癌再発
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=639
end-page=649
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Long-term follow-up study od total hip replacement in rheumatoid arthritis
kn-title=慢性関節リウマチにおける全人工股関節置換術長期成績に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A long-term follow up study was performed on 125 total hip replacements (THR) in 95 rheumatoid patients. The average follow up time was 8 years and 5 months, ranging from 5 to 17 years. Except in 26 cases of death or 9 incomplete histories at the follow-up, 62 cases were investigated both clinically and radiologically. For the operations, two types of prostheses (Charnley and C-Muller ) were used. According to the Japan Orthopaedic Association (JOA) hip score, the preoperative score improved from 32.9 to 57.1 points at the final postoperative evaluation. In the radiological assessment using the method by Nagaya and Uno, a clear zone was seen around the acetabular cup in 82.2% of the hips and around the femoral stem in 53.2%. Rate of loosening corresponding to stage Ⅲ and Ⅳ was 20.2% in the acetabular side and 32.9% in the femoral side. Charnley-type group was better than C-Muller type both in clinical and radiological assessments. Twelve cases had lost walking ability. As postoperative complications, deep infections occurred in 4 hips, femoral shaft fracture in 4 hips, dislocation in 1 hip and revision due to aseptic loosening in 4 hips. THR may be useful for rheumatoid patients and improve the quality of life in the case of long-term disease if careful pre-and post-operative care is provided.
en-copyright=
kn-copyright=

en-aut-name=OosakiKazuhiko
en-aut-sei=Oosaki
en-aut-mei=Kazuhiko
kn-aut-name=大﨑和彦
kn-aut-sei=大﨑
kn-aut-mei=和彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部整形外科学教室
en-keyword=慢性関節リウマチ
kn-keyword=慢性関節リウマチ
en-keyword=全人工股関節置換術
kn-keyword=全人工股関節置換術
en-keyword=長期追跡調査
kn-keyword=長期追跡調査
en-keyword=合併症
kn-keyword=合併症
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=1-2
article-no=
start-page=183
end-page=197
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental study on pathogenesis and treatment of cerebral vasospasm Part 2. Effects of PGI2 analogue, thromboxane A2 synthetase inhibitor and Ca blocker on experimental delayed spasm models
kn-title=脳血管攣縮の発生機序と治療に関する実験的研究 第2編 実験的遅発性脳血管攣縮に対する PGI2 analogue, Thromboxane A2 合成酵素阻害剤, Ca 拮抗剤の効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of a PGI2 analogue (OP-41483), a thromboxane A2 synthetase inhibitor (OKY-046) and a Ca blocker (nifedipine) on the diameter of constricted basilar arteries and on the regional cerebral blood flow (r-CBF) in the brain stem were investigated in the cat delayed spasm model. The experiment was performed three days (72 hours) after artificial subarachnoid hemorrhage. The basilar artery was exposed transclivally, and more advanced vasospasm was produced by topical application of a lysed erythrocyte solution for 5 to 6 hours which domonstrated no more vascular dilatation even by topical application of papaverine hydrochloride (0.01mg/ml). In the delayed spasm model, the intravenous administration of neither OP-41483 (8μg/kg), OKY-046 (60mg/kg) nor nifedipine (0.003mg/kg) affected the vascular diameter. OP-41483 increased r-CBF in the brain stem in 3, and nifedipine increased it in 4 out of the 5 studied delayed spasm models, whereas OKY-046 never increased r-CBF (n=5). There was no significant difference in the amount of fatty acids including arachidonic acid between normal and constricted arteries. This study suggested that thromboxane A2 is not the major factor of cerebral vasospasm and OKY-046 might not be effective on vascular diameter or r-CBF at the late spasm stage. However, the PGI2 analogue (OP-41483) and Ca blocker (nifedipine) may be effective in increasing r-CBF even at the late spasm stage.
en-copyright=
kn-copyright=

en-aut-name=MotokiMototsugu
en-aut-sei=Motoki
en-aut-mei=Mototsugu
kn-aut-name=元木基嗣
kn-aut-sei=元木
kn-aut-mei=基嗣
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳神経外科教室
en-keyword=cerebral vasospasm
kn-keyword=cerebral vasospasm
en-keyword=thromboxane A2
kn-keyword=thromboxane A2
en-keyword=OP-41483
kn-keyword=OP-41483
en-keyword=OKY-046
kn-keyword=OKY-046
en-keyword=nifedipine
kn-keyword=nifedipine
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=1
article-no=
start-page=9
end-page=16
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=200902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Estimation of Completion of Dormancy in Grapevine Bud Based on Cumulative Temperature
kn-title=積算温度によるブドウの芽の休眠完了予測
en-subtitle=
kn-subtitle=
en-abstract=ブドウの芽の休眠完了と温度との関係を調査するため，温度条件の異なる７園（中信農試，山梨果試，岡山農試，岡山農試北部支場，岡山大学，福岡農試および宮崎）で栽培されている‘巨峰’と‘ピオーネ’から低温遭遇量の異なる３時期（12月，１月，２月）に結果母枝を採取した．直ちに岡山大学に送り，１芽を持つ挿し穂に調整した後，25または30℃のインキュベーター（14時間日長）に入れ，２日間隔で60日間発芽を調査した．処理開始時の7.2℃以下の遭遇量は中信農試で最も多く，次いで岡山農試北部支場，山梨果試，岡山農試，岡山大学，福岡農試，宮崎の順で，中信農試と宮崎では処理時期により2.5～4.8倍の差があった．発芽所要日数は，両品種とも処理時期が遅いほど，また温度が高いほど少なく，60％発芽所要日数もほぼ同様の傾向であった．‘巨峰’の発芽所用日数は中信農試，岡山大学および宮崎で少ない一方，岡山農試，山梨果試および福岡農試で多く，また‘ピオーネ’では福岡農試と岡山大学で少なく，山梨果試と岡山農試で多かった．７園のうち４園で低温遭遇量と発芽所要日数との間に負の相関がみられたが，相関係数は低かった．一方，11月以降処理開始までの０℃以上の温度の積算値と処理開始から発芽までの25または30℃での積算値を合計した積算温度と発芽所要日数との間には１園を除き極めて高い正の相関が認められた．これらの結果を基に，積算温度によるブドウの休眠完了予測の可能性を考察した．
kn-abstract=　This study was conducted to investigate the relationship between completion of dormancy of grapevine
bud and temperature. Canes of ‘Kyoho’ and ‘Pione’ grapevines (Vitis labrusca×V. vinifera) grown in 7 vineyards with different temperature conditions, in Nagano, Northern Okayama, Yamanashi, Okayama, Okayama University, Fukuoka and Miyazaki, were collected at three different chilling exposures,
December, January and February. These were then sent to Okayama University all at the same time. Cuttings with one bud were put into growth chambers kept at 25 or 30°C with 14 hours daylength, and budbreak in each cutting was surveyed at two day intervals for 60 days. Cumulative chilling hours (CCH) of exposure to below 7.2°C in each treatment time was largest in Nagano, followed in order by Northern Okayama, Yamanashi, Okayama, Okayama University, Fukuoka and Miyazaki. The CCH in Nagano was 2.5 to 4.8 times larger than in Miyazaki depending on the treatment time. The later the treatment time and the higher the temperature, the fewer were the number of days to first budbreak (NDFB) after treatment, irrespective of cultivar. A similar trend was observed in the number of days to 60% budbreak. In ‘Kyoho’ the NDFB was short in Nagano, Okayama University and Miyazaki, and longer in Okayama, Yamanashi and Fukuoka. In ‘Pione’ the NDFB was short in Fukuoka and Okayama University, and longer in Yamanashi and Okayama. The result was a weak negative correlation observed between CCH and NDFB in 4 of 7 vineyards. However, there was a strong positive correlation between NDFB and cumulative temperature (CT), a summation of temperature and hours of exposure to above 0°C from November 1 to treatment time and hours of exposure to 25 or 30°C from start of treatment to budbreak in each plot, in 6 vineyards excluding Miyazaki. The importance of estimating the completion of dormancy in grapevine bud based on CT is discussed.
en-copyright=
kn-copyright=

en-aut-name=KubotaNaohiro
en-aut-sei=Kubota
en-aut-mei=Naohiro
kn-aut-name=久保田尚浩
kn-aut-sei=久保田
kn-aut-mei=尚浩
aut-affil-num=1
ORCID=

en-aut-name=PotjanapimonChaiwat
en-aut-sei=Potjanapimon
en-aut-mei=Chaiwat
kn-aut-name=ポジャナピモンチャイワット
kn-aut-sei=ポジャナピモン
kn-aut-mei=チャイワット
aut-affil-num=2
ORCID=

en-aut-name=FukudaFumio
en-aut-sei=Fukuda
en-aut-mei=Fumio
kn-aut-name=福田文夫
kn-aut-sei=福田
kn-aut-mei=文夫
aut-affil-num=3
ORCID=

en-aut-name=FujiiaYuichiro
en-aut-sei=Fujiia
en-aut-mei=Yuichiro
kn-aut-name=藤井雄一郎
kn-aut-sei=藤井
kn-aut-mei=雄一郎
aut-affil-num=4
ORCID=

en-aut-name=OnoToshiro
en-aut-sei=Ono
en-aut-mei=Toshiro
kn-aut-name=小野俊朗
kn-aut-sei=小野
kn-aut-mei=俊朗
aut-affil-num=5
ORCID=

en-aut-name=KurafujiYuki
en-aut-sei=Kurafuji
en-aut-mei=Yuki
kn-aut-name=倉藤祐輝
kn-aut-sei=倉藤
kn-aut-mei=祐輝
aut-affil-num=6
ORCID=

en-aut-name=OgoroAtsuo
en-aut-sei=Ogoro
en-aut-mei=Atsuo
kn-aut-name=尾頃敦郎
kn-aut-sei=尾頃
kn-aut-mei=敦郎
aut-affil-num=7
ORCID=

en-aut-name=KunugiYukihiro
en-aut-sei=Kunugi
en-aut-mei=Yukihiro
kn-aut-name=功刀幸博
kn-aut-sei=功刀
kn-aut-mei=幸博
aut-affil-num=8
ORCID=

en-aut-name=KobayashiKazushi
en-aut-sei=Kobayashi
en-aut-mei=Kazushi
kn-aut-name=小林和司
kn-aut-sei=小林
kn-aut-mei=和司
aut-affil-num=9
ORCID=

en-aut-name=ShigeharaIzumi
en-aut-sei=Shigehara
en-aut-mei=Izumi
kn-aut-name=茂原泉
kn-aut-sei=茂原
kn-aut-mei=泉
aut-affil-num=10
ORCID=

en-aut-name=YamashitaHiroyuki
en-aut-sei=Yamashita
en-aut-mei=Hiroyuki
kn-aut-name=山下裕之
kn-aut-sei=山下
kn-aut-mei=裕之
aut-affil-num=11
ORCID=

en-aut-name=FujishimaHiroyuki
en-aut-sei=Fujishima
en-aut-mei=Hiroyuki
kn-aut-name=藤島宏之
kn-aut-sei=藤島
kn-aut-mei=宏之
aut-affil-num=12
ORCID=

affil-num=1
en-affil=
kn-affil=応用植物科学コース

affil-num=2
en-affil=
kn-affil=応用植物科学コース

affil-num=3
en-affil=
kn-affil=応用植物科学コース

affil-num=4
en-affil=
kn-affil=岡山県農業総合センター農業試験場

affil-num=5
en-affil=
kn-affil=岡山県農業総合センター農業試験場

affil-num=6
en-affil=
kn-affil=岡山県農業総合センター農業試験場

affil-num=7
en-affil=
kn-affil=岡山県農業総合センター農業試験場

affil-num=8
en-affil=
kn-affil=山梨県果樹試験場

affil-num=9
en-affil=
kn-affil=山梨県果樹試験場

affil-num=10
en-affil=
kn-affil=長野県中信農業試験場

affil-num=11
en-affil=
kn-affil=長野県中信農業試験場

affil-num=12
en-affil=
kn-affil=福岡県農業総合試験場
en-keyword=budbreak
kn-keyword=budbreak
en-keyword=chilling exposure
kn-keyword=chilling exposure
en-keyword=growing region
kn-keyword=growing region
en-keyword=temperature condition
kn-keyword=temperature condition
en-keyword=Vitis labrusca × V. vinifera
kn-keyword=Vitis labrusca × V. vinifera
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=9-10
article-no=
start-page=1097
end-page=1102
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on alveolar macrophage function in interstitial lung disease Part 2. Abnormalities of alveolar macrophages in sarcoidosis and the correlations with clinical findings
kn-title=間質性肺疾患における肺胞マクロファージに関する研究　第2編　サルコイドーシスにおける肺胞マクロファージ活性と疾患活動性との比較について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Several abnormalities of alveolar macrophage function were found in patients with sarcoidosis, and such abnormalities reflected the recruitment of immature macrophages to the local sites. In this study, alveolar macrophage function was compared with the disease activity in patients with sarcoidosis. The alveolar macrophage phagocytic index correlated closely with the spleen index obtained by ultrasonography, but not with serum angiotensin converting enzyme levels, lung function tests, or the cell differentiations of bronchoalveolar lavage fluid. The patients who had a positive uptake of 67-gallium scintigram showed a higher phagocytic index and a higher percentage of CD15-positive alveolar macrophages than those with negative scintigrams. Acid phosphatase activity and the percentage of CD15-positive alveolar macrophages were increased in patients with negative PPD skin tests compared to those with positive tests. We previously reported that alveolar lymphocytes in patients with sacroidosis are sensitized to Propionibacterium acnes (P. acnes), which may play a significant role in the induction of alveolitis in these patients. There was a significant correlation between the blastogenesis of alveolar lymphocytes induced by P. acnes and beta-galactosidase activity as well as the percentage of CD14-positive alveolar macrophages. These findings suggest that alveolar macrophages play an important role in the pathogenesis of sarcoidosis, in which the clinical abnormalities may reflect abnormal alveolar macrophage function.
en-copyright=
kn-copyright=

en-aut-name=HosoyaShigee
en-aut-sei=Hosoya
en-aut-mei=Shigee
kn-aut-name=細谷茂衛
kn-aut-sei=細谷
kn-aut-mei=茂衛
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=alveolar macrophage
kn-keyword=alveolar macrophage
en-keyword=sarcoidosis
kn-keyword=sarcoidosis
en-keyword=Propionibacterium acnes
kn-keyword=Propionibacterium acnes
en-keyword=lymphocyte blastgenesis
kn-keyword=lymphocyte blastgenesis
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=7-8
article-no=
start-page=983
end-page=992
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=199108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Evaluation of health examination program for 3 year old children : Follow-up study on screening of urine examination
kn-title=三歳児健康診査の評価―検尿の意義と判定方法―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study focuses on the health examination programs for 3 year old children from a public health point of view. The methodology, items tested, criteria and follow-up systems of urine examination were evaluated. Results of urine examinations of 8,615 children(male : 4,490, female : 4,125), who had been in the health examination program from 1980 to 1985, were studied in the area of K-ku in Y-city. Moreover a follow-up study was performed to discuss the significance of urine examination as mass screening. In the health examination program for 3 year old children, it is efficient to classify those with a score of more than “one plus” into the high risk group with regard to proteinuria and hematuria. It is possible to reduce the false positive rate by checking first morning urine at re-examination. A bettr information net work system must be established to utilize the results of mass health examinations for three year old children.
en-copyright=
kn-copyright=

en-aut-name=TanakaKatsuko
en-aut-sei=Tanaka
en-aut-mei=Katsuko
kn-aut-name=田中克子
kn-aut-sei=田中
kn-aut-mei=克子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部衛生学教室
en-keyword=3歳児健康診査
kn-keyword=3歳児健康診査
en-keyword=検尿
kn-keyword=検尿
en-keyword=健康診査の評価
kn-keyword=健康診査の評価
en-keyword=追跡調査
kn-keyword=追跡調査
en-keyword=学童健診
kn-keyword=学童健診
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=3-4
article-no=
start-page=297
end-page=310
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical and histological studies on steroid-induced avascular necrosis of the femoral head, especially in ststemic lupus erythematosus
kn-title=ステロイド性大腿骨頭壊死症の病態に関する研究―全身性エリテマトーデス(SLE)を中心に―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Clinical and radiological studies were performed on avascular necrosis of the femoral head (ANF) in 220 hips 140 patients including 51 hips of 28 patients with systemic lupus erythe-matosus (SLE group). Sixty-nine hips of 41 patients wee treated with corticosteroid adminis-tration (S group) and 100 hips of 71 patients without corticosteroid administration (Non-S group). All patients with SLE were treated with corticosteroid adminstration. Thirty-one femoral heads (11 heads of SLE group, 9 heads of S group and 11 heads of Non-S group) were resected at operations nad studied histologically. Seventy-seven hips at an early stage showed that collapse of the femoral heads occurred in 80% without 3 years and no differences were found among these group. In the SLE group, bilateral involvement, multiple bone necrosis and predilection for young females were apparent. Collapse of the femoral head and subcapital fractures were more frequently seen in the SLE group. Histologically, almost all heads even in the SLE group showed repair process such as enchondral ossification and appositional bone formation, while the heads with subcapital fracture showed no such no such changes.
en-copyright=
kn-copyright=

en-aut-name=UsuiMasaaki
en-aut-sei=Usui
en-aut-mei=Masaaki
kn-aut-name=臼井正明
kn-aut-sei=臼井
kn-aut-mei=正明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部整形外科学教室
en-keyword=大腿骨頭壊死症
kn-keyword=大腿骨頭壊死症
en-keyword=全身性エリテマトーデス(SLE)
kn-keyword=全身性エリテマトーデス(SLE)
en-keyword=病態
kn-keyword=病態
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=3-4
article-no=
start-page=259
end-page=266
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental and clinical studies on interferon and its inducers Part 2. β-carboxyethylgermanium sesquioxide (Ge-132) in the management of acute nonlymphocytic leukemia patients at remission phase
kn-title=インターフェロン並びにインターフェロン誘発剤に関する基礎的・臨床的研究　第2編　急性非リンパ性白血病寛解期における β-Carboxyethylgermanium sesquioxide (Ge-132) の臨床効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The clinieal of Ge-132 in the management of acute nonlymphocytic leukemia (ANLL) patients at remission phase were studied. Twenty-two ANLL patients with complete remission were randomized into Groups A and B. Patients in Group A were treated with the combianation with Ge-132 (2,250mg/day ; p. o daily) and intermittent-alternating chemotherapy 〔daunorubicin, vincristine, cytosine arabinoside and prednisolone (DVCP)/aclarubicin vincristine cytosine arabinoside and prednisolone (AVCP)〕and patients in Groyp B were treated with intermittent-alter nating chemotherapy (DVCP/AVCP) alone. Evaluable patients were 7 in Group A and 10 in Group B. Remission duration and survival time were not significantly different between Groups A and B. (median remission duration ; 5.7 month in Group A vs 8.1 month in Group B/median surival time ; 23.9month in Group A vs 18.3month in Group B) The rates of second remission in relapsed cases were not significantly different between Groups A and B.〔2 of 7,(28.6%) in Group A vs 3 of 10,(30.0%) in B〕Ge-132 did not accelerate the recovery from myelosuppression after intensification with the DVCP regimen. The incidence of liver damage and levels of serum GOT and GPT tended to be lower in Group A than in Group B. In this clinical study the incidence of liver damage tended to be lowere in patients treated with Ge-132. The liver damage which often develops during intensificantion chemotherapy, not only limits the chemotherapy but also causes adverse effects on the quality of life of the patient. In part 1 of this series, Ge-132 was reported to activate the neutrophil chemiluminescence. Ge-132 seems to be useful in the management of ANLL patients not only by the enhancement of the host defense system but also by the prevenation of liver damage.
en-copyright=
kn-copyright=

en-aut-name=FukumotoMitsuhiro
en-aut-sei=Fukumoto
en-aut-mei=Mitsuhiro
kn-aut-name=福本光宏
kn-aut-sei=福本
kn-aut-mei=光宏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=Ge-132
kn-keyword=Ge-132
en-keyword=Biological response modifier
kn-keyword=Biological response modifier
en-keyword=Acute nonlymphocytic leukemia
kn-keyword=Acute nonlymphocytic leukemia
en-keyword=Immunotherapy
kn-keyword=Immunotherapy
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=11-12
article-no=
start-page=1159
end-page=1171
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Mechanism of inhibitory effect of dorsal column stimulation (DCS) on spasticity : Role of presynaptic inhibition in monosynaptic reflex
kn-title=Spasticity に対する脊髄硬膜外刺激の作用メカニズムに関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To investigate the mechanism of the inhibitory effect of dorsal column stimulation (DCS) on the monosynaptic reflex, excitability of the Ia fiber terminal was measured by Wall's method before, during and after epidural spinal cord stimulation. The experiment was performed under general anesthesia on five normal cats and five cats which had undergone hemisection of the lower thoracic cord more than three weeks before the experiment. Bipolar silver-ball electrodes were placed epidurally on the midline of the thoracic cord, caudal to the hemisected site. During and after DCS, increase of the excitability of the Ia fiber terminal was observed in both normal and hemisected cats, suggesting that the presynaptic inhibition at the Ia fiber terminal plays an important role in inhibition of the monosynaptic reflex. Moreover, this excitability change was maintained more than ten minutes after cessation of DCS, compatible with a clinical observation that the inhibitory effect of DCS on spasticity often continues after turning off the stimulating system. However the mechanism of this after-effect is unknown.
en-copyright=
kn-copyright=

en-aut-name=MunedaKouji
en-aut-sei=Muneda
en-aut-mei=Kouji
kn-aut-name=棟田耕二
kn-aut-sei=棟田
kn-aut-mei=耕二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳神経外科学教室
en-keyword=spasticity
kn-keyword=spasticity
en-keyword=dorsal column stimulation
kn-keyword=dorsal column stimulation
en-keyword=monosynaptic reflex
kn-keyword=monosynaptic reflex
en-keyword=presynaptic inhibition
kn-keyword=presynaptic inhibition
en-keyword=primary afferent depolarization
kn-keyword=primary afferent depolarization
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=3-4
article-no=
start-page=241
end-page=246
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The effect of cyclosporin A on liver regeneration
kn-title=肝再生に及ぼす Cyclosporin A の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=When lymphokine activiated killer cells (LAK cell) induced by IL-2 are infused into the same strain C(3)H mice following 70% partial hepatectomy, they display an action to suppress liver regeneration. Therefore, when Cyclosporin A (CsA) which inhibits IL-2 production was administerd to mice following partial hepatectomy, we studied as our indicator the labeling index of hepatic parenchyma cells using Brdu. Our findings showed that proliferation of live cells at 36 hours following partial hepatectomy was promoted by CsA, and the streongest promotion occuring at a dose of 5mg/kg. Before anf after hepatectomy when CsA was administered at 10mg/kg for 3 dadys, a further strong proliferation increasing effect was observed, and under these conditions at 48 and 60 hours after hepatectomy a significant increase in liver weight was observed. Give the above results, CsA  it thought to have a promoting effect in liver regeneration following hepatectomy.
en-copyright=
kn-copyright=

en-aut-name=YamamotoHiroshi
en-aut-sei=Yamamoto
en-aut-mei=Hiroshi
kn-aut-name=山本浩史
kn-aut-sei=山本
kn-aut-mei=浩史
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=Cyclosporin A
kn-keyword=Cyclosporin A
en-keyword=肝再生
kn-keyword=肝再生
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=11-12
article-no=
start-page=1093
end-page=1105
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effects of guanidino compounds on monoamine oxidase and catechol-O-methyltransferase activity
kn-title=モノアミン代謝酵素活性に及ぼすグアニジノ化合物の影響に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the central nervous system (CNS)of mammals, monoamine oxidase (EC 1.4.3.4)(MAO), which have been divided into two functional forms (MAO-A and MAO-B), and catechol-O-methyltransferase (EC 2.1.1.6)(COMT) act as catabolic enzymes of catecholamines and serotonin regulating their concentrations. In this study, the effects of guanidino compounds (5mM) on MAO-A, MAO-B and COMT were examined to invastigate the role of guanidino compounds in CNS function. MAO-A activity was decreased by α-guanidinoglutaric acid (GGA) and guanidinoethanesulfonic acid, and increased by arginine (Arg) and N-acetylarginine at a low substrate concentration (4.33μM). MAO-B activity was decreased by creatinine (CRN), δ-guanidinovaleric acid (GVA) and methylguanidine (MGua) at a high substrate concentration (3.125mM), and decreased by CRN, GVA, MGua, Arg, guanidine, 2-guanidinoethanol, β-guanidinopropionic acid, guanidinosuccinic acid and homoarginine at a low substrate concentration (62.5μM). GVA, CRN and MGua acted as competitive inhibitors on MAO-B and their calculated Ki values were 9.47mM, 14.5mM and 29.4mM, respectively. Although the guanidino compounds tested had no effect on COMT activity at a high substrate concentration (600μM), GSA and GVA inhibited COMT activity at a low substrate concentration (75μM). These results suggest that some guanidino compounds influence catabolic enzymes of indoleamine and catecholamines to control CNS function.
en-copyright=
kn-copyright=

en-aut-name=HukuyamaKatsuhisa
en-aut-sei=Hukuyama
en-aut-mei=Katsuhisa
kn-aut-name=福山勝久
kn-aut-sei=福山
kn-aut-mei=勝久
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部附属分子細胞医学研究施設神経情報学部門
en-keyword=guanidino compounds
kn-keyword=guanidino compounds
en-keyword=monoamine oxidase A
kn-keyword=monoamine oxidase A
en-keyword=monoamine oxidase B
kn-keyword=monoamine oxidase B
en-keyword=chatechol-O-methyltransferase
kn-keyword=chatechol-O-methyltransferase
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=9-10
article-no=
start-page=915
end-page=922
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Development of double cancer in small cell lung cancer patients treated with intensive chemotherapy
kn-title=肺小細胞癌化学療法実施例における重複癌の発生に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Development of double cancer was evaluated in 337 small cell lung cancer patients who had received intensive chemotherapy with or without radiotherapy. Of them, 14 patients (4.2%) developed a second malignancy: non-small cell lung cancer in six, stomach cancer in four, acute myelogenous leukemia in two, liver cancer in one, and esophagus cancer in one. The relative risk for the development of double cancer calculated by person-year method utilizing age and sex adjusted cancer incidence in Japan was 2.75-fold (P<0.01). The risk of non-small cell lung cancer (8.75-fold) and acute myelogenous leukemia (37.82-fold) was particularly high. The cumulative risk for the development of double cancer was 2.0% at 1 year, 4.1% at 2 years, 14.3% at 3 years, and 100% at 8.1 years. Of 27 patients who survived disease-free for more than 2 years, 10 patients died; five patients (50%) died of double cancer, two died of infectious disease, and only three patients died from recurrent small cell lung cancer. These findings indicate that a cautious follow-up program for the detection of double cancer is indicated in patients with small cell lung cancer.
en-copyright=
kn-copyright=

en-aut-name=MiyakeKenichi
en-aut-sei=Miyake
en-aut-mei=Kenichi
kn-aut-name=三宅賢一
kn-aut-sei=三宅
kn-aut-mei=賢一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=肺小細胞癌
kn-keyword=肺小細胞癌
en-keyword=化学療法
kn-keyword=化学療法
en-keyword=重複癌
kn-keyword=重複癌
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=1-2
article-no=
start-page=29
end-page=38
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The reconstructive surgery of head and neck cancers
kn-title=頭頸部癌の再建外科―当科における再建術式の臨床的観察―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Thiry nine reconstructive surgeries were performed in 37 cases of head and neck cancers from January, 1989 to August, 1991 in our department. The best functional results were obtained on deglutition, swallowing and phonatin after intraoral and/or mesopharyngeal reconstruction using free radial forearm flaps. The free jejunal transposition procedure had the lowest complication rate. The rectus abdominus musculocutaneous free flap was used for nasal, paranasal reconstruction. Esthetics could be presereved by this reconstruction method due to mider postoperative atrophy and contraction. Eye sockets for the artificial eyes were made with eye conjunctiva in 3 canses of extended total maxillectomy with the orbital exenteration. The use of microvas-cular free flaps in this new plastic surgery resulted in the decrease of refusal of operations in maxillectomy canses.
en-copyright=
kn-copyright=

en-aut-name=WatanabeShuichi
en-aut-sei=Watanabe
en-aut-mei=Shuichi
kn-aut-name=渡辺周一
kn-aut-sei=渡辺
kn-aut-mei=周一
aut-affil-num=1
ORCID=

en-aut-name=KawakamiTakashi
en-aut-sei=Kawakami
en-aut-mei=Takashi
kn-aut-name=川上登史
kn-aut-sei=川上
kn-aut-mei=登史
aut-affil-num=2
ORCID=

en-aut-name=InokuchiIkuo
en-aut-sei=Inokuchi
en-aut-mei=Ikuo
kn-aut-name=井口郁雄
kn-aut-sei=井口
kn-aut-mei=郁雄
aut-affil-num=3
ORCID=

en-aut-name=UnoKin-ya
en-aut-sei=Uno
en-aut-mei=Kin-ya
kn-aut-name=宇野鉄哉
kn-aut-sei=宇野
kn-aut-mei=鉄哉
aut-affil-num=4
ORCID=

en-aut-name=OhomichiTakuya
en-aut-sei=Ohomichi
en-aut-mei=Takuya
kn-aut-name=大道卓也
kn-aut-sei=大道
kn-aut-mei=卓也
aut-affil-num=5
ORCID=

en-aut-name=FukazawaMotoharu
en-aut-sei=Fukazawa
en-aut-mei=Motoharu
kn-aut-name=深沢元晴
kn-aut-sei=深沢
kn-aut-mei=元晴
aut-affil-num=6
ORCID=

en-aut-name=YonedaTakaaki
en-aut-sei=Yoneda
en-aut-mei=Takaaki
kn-aut-name=米田孝明
kn-aut-sei=米田
kn-aut-mei=孝明
aut-affil-num=7
ORCID=

en-aut-name=FukushimaKunihiro
en-aut-sei=Fukushima
en-aut-mei=Kunihiro
kn-aut-name=福島邦博
kn-aut-sei=福島
kn-aut-mei=邦博
aut-affil-num=8
ORCID=

en-aut-name=MasudaYu
en-aut-sei=Masuda
en-aut-mei=Yu
kn-aut-name=増田游
kn-aut-sei=増田
kn-aut-mei=游
aut-affil-num=9
ORCID=

en-aut-name=KamikawaYasuaki
en-aut-sei=Kamikawa
en-aut-mei=Yasuaki
kn-aut-name=上川康明
kn-aut-sei=上川
kn-aut-mei=康明
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=10
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=再建外科
kn-keyword=再建外科
en-keyword=頭頸部癌
kn-keyword=頭頸部癌
en-keyword=有茎 (筋) 皮弁
kn-keyword=有茎 (筋) 皮弁
en-keyword=遊離 (筋) 皮弁
kn-keyword=遊離 (筋) 皮弁
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=5-6
article-no=
start-page=575
end-page=587
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=1993
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Correlation between congnitive and motor function in elderly patients with hypertension
kn-title=高齢高血圧患者における認知機能と運動機能との関連
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study examined the correlation between decline in cognitive and motor functions in elderly patients with hypertension. The Mini-Mental State Examination (MMSE) and the Motor Age Test (MOA) were administered to 185 outpatients with hypertension aged 65 or older. In multiple regression analysis, increasing age and history of cerebrovascular disease were significantly related to lower performance on MMSE and MOA. Fewer years of education were also associated with lower performance on MMSE. Vertebral deformity had a significant negative effect on MOA. After controlling other variables, there was a significant correlation between performances of MMSE and MOA. The correlation between cognitive and motor function, which was independent of increasing age and cerebrovascular disease, may indicate common pathogenic mechanisms underlying cognitive and motor deterioration in elderly patients with hypertension.
en-copyright=
kn-copyright=

en-aut-name=MatsuokaHiroaki
en-aut-sei=Matsuoka
en-aut-mei=Hiroaki
kn-aut-name=松岡宏明
kn-aut-sei=松岡
kn-aut-mei=宏明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部衛生学教室
en-keyword=高齢高血圧症
kn-keyword=高齢高血圧症
en-keyword=ミニ・メンタル・ステート
kn-keyword=ミニ・メンタル・ステート
en-keyword=運動発達年齢
kn-keyword=運動発達年齢
en-keyword=重回帰分析
kn-keyword=重回帰分析
END