start-ver=1.4
cd-journal=joma
no-vol=23
cd-vols=
no-issue=68
article-no=
start-page=17191
end-page=17194
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Total Synthesis of Two Possible Diastereomers of Natural 6-Chlorotetrahydrofuran Acetogenin and Its Stereostructural Elucidation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The first total synthesis of two possible diastereomers of natural 6-chlorotetrahydrofuran acetogenin 1 has been achieved. The synthetic route features 5-exo-tet cyclization, Z selective Wittig reaction and Julia olefination for the construction of conjugated diene and enyne moieties, and stereoselective chlorination. Comparison of their 1 H and 13 C?NMR data and specific rotation with those of the natural product elucidated the absolute configuration of natural (-)-6-chlorotetrahydrofuran acetogenin 1.
en-copyright=
kn-copyright=

en-aut-name=TakamuraHiroyoshi
en-aut-sei=Takamura
en-aut-mei=Hiroyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KatsubeTomoya
en-aut-sei=Katsube
en-aut-mei=Tomoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkamotoKazuki
en-aut-sei=Okamoto
en-aut-mei=Kazuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KadotaIsao
en-aut-sei=Kadota
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil= Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil= Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil= Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil= Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=natural products
kn-keyword=natural products
en-keyword=stereoselective synthesis
kn-keyword=stereoselective synthesis
en-keyword=structure elucidation
kn-keyword=structure elucidation
en-keyword=tetrahydrofuran
kn-keyword=tetrahydrofuran
en-keyword=total synthesis
kn-keyword=total synthesis
END