ID | 32982 |
FullText URL | |
Author |
Hayashi, Mitsuko
Yatsushiro, Shouki
Ishio, Shougo
Yamamoto, Akitsugu
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Abstract | Microvesicles in endocrine cells are the morphological and functional equivalent of neuronal synaptic vesicles. Microvesicles accumulate various neurotransmitters through a transmitter-specific vesicular transporter energized by vacuolar H+-ATPase. We found that mammalian pinealocytes, endocrine cells that synthesize and secrete melatonin, accumulate L-glutamate in their microvesicles and secrete it through exocytosis. Pinealocytes use L-glutamate as either a paracrine- or autocrine-like chemical transmitter in a receptor-mediated manner, resulting in inhibition of melatonin synthesis. In this article, we briefly describe the overall features of the microvesicle-mediated signal-transduction mechanism in the pineal gland and discuss the important role of acidic organelles in a novel regulatory mechanism for hormonal synthesis and secretion.
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Keywords | V-ATPase
melatonin
L-glutamate
serotonin
paracrine
autocrine
pinealocyte
endocrine cell.
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Note | Published with permission from the copyright holder. This is the institute's copy, as published in The Journal of Experimental Biology, January 2000, Volume 203, Issue 1, Pages 117-125.
Publisher URL: Copyright © 2000 The Company of Biologists Limited. All rights reserved. |
Published Date | 2001-01
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Publication Title |
The Journal of Experimental Biology
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Volume | volume203
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Issue | issue1
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Publisher | The Company of Biologists Limited
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Start Page | 117
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End Page | 125
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ISSN | 0022-0949
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NCID | AA00697490
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Content Type |
Journal Article
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language |
English
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Copyright Holders | The Company of Biologists Limited
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT | |
Submission Path | biology_general/9
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