ID | 46919 |
FullText URL | |
Author |
Kurami, Shunsuke
Sisido, Masahiko
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Abstract | To investigate the antisense effect of a pyrrolidine-based oxy-peptide nucleic acid (POPNA), we carried out the LacZ reporter assay using a 12-mer trans-l-POPNA conjugated with a cell-penetrating peptide (antisense reagent). The antisense effect of the conjugated POPNA (inhibition of LacZ activity) was comparable to that shown by a Nielsen-type peptide nucleic acid. Furthermore, the conjugated POPNA could switch the LacZ activity over a wide range of ambient temperatures.
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Keywords | Peptide nucleic acid
Cell-penetrating peptide
Antisense effect
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Published Date | 2011-01
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Publication Title |
Bioorganic & Medicinal Chemistry Letters
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Volume | volume21
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Issue | issue1
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Publisher | Pergamon-Elsevier Science Ltd,
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Start Page | 225
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End Page | 227
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ISSN | 0960-894X
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NCID | AA1079577X
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Content Type |
Journal Article
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language |
English
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Copyright Holders | © 2010 Elsevier Ltd. All rights reserved.
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File Version | author
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Refereed |
True
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DOI | |
PubMed ID | |
Web of Science KeyUT |