FullText URL Vasc_Health_Risk_Manag_11_265.pdf
Author Saito, Yukihiro| Nakamura, Kazufumi| Akagi, Satoshi| Sarashina, Toshihiro| Ejiri, Kentaro| Miura, Aya| Ogawa, Aiko| Matsubara, Hiromi| Ito, Hiroshi|
Abstract  The release of endogenous prostacyclin (PGI2) is depressed in patients with pulmonary arterial hypertension (PAH). PGI2 replacement therapy by epoprostenol infusion is one of the best treatments available for PAH. Here, we provide an overview of the current clinical data for epoprostenol. Epoprostenol treatment improves symptoms, exercise capacity, and hemodynamics, and is the only treatment that has been shown to reduce mortality in patients with idiopathic PAH (IPAH) in randomized clinical trials. We have reported that high-dose epoprostenol therapy (>40 ng/kg/min) also results in marked hemodynamic improvement in some patients with IPAH. High-dose epoprostenol has a pro-apoptotic effect on PAH-PASMCs via the IP receptor and upregulation of Fas ligand (FasL) in vitro. However, long-term intravenous administration of epoprostenol is sometimes associated with catheter-related infections and leads to considerable inconvenience for the patient. In the future, the development of new routes of administration or the development of powerful PGI2 analogs, IP-receptor agonists, and gene and cell-based therapy enhancing PGI2 production with new routes of administration is required.
Keywords apoptosis prostacyclin pulmonary arterial hypertension
Note 学位審査副論文
Published Date 2015-05-14
Publication Title Vascular Health and Risk Management
Volume volume11
Publisher Dove Medical Press
Start Page 265
End Page 270
ISSN 1176-6344
NCID AA12158664
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version publisher
PubMed ID 25999730
DOI 10.2147/VHRM.S50368
Web of Sience KeyUT 000210424400027
Related Url https://doi.org/10.2147/VHRM.S50368 http://ousar.lib.okayama-u.ac.jp/55246
Author Koreishi, Mayuko| Honjo, Yasuko| Satoh, Ayano|
Published Date 201-08-09
Publication Title Antibody Technology Journal
Volume volume2011
Issue issue1
Content Type Journal Article