ID | 57457 |
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Sumi, Tomonari
Research Institute for Interdisciplinary Science and Department of Chemistry, Faculty of Science, Okayama University
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Okumoto, Atsushi
Department of Computer Science and Engineering, Graduate School of Engineering, Toyohashi University of Technology
Goto, Hitoshi
Department of Computer Science and Engineering, Graduate School of Engineering, Toyohashi University of Technology
Sekino, Hideo
Department of Computer Science and Engineering, Graduate School of Engineering, Toyohashi University of Technology
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Abstract | A two-step subdiffusion behavior of lateral movement of transmembrane proteins in plasma membranes has been observed by using single-molecule experiments. A nested double-compartment model where large compartments are divided into several smaller ones has been proposed in order to explain this observation. These compartments are considered to be delimited by membrane-skeleton "fences" and membrane-protein "pickets" bound to the fences. We perform numerical simulations of a master equation using a simple two-dimensional lattice model to investigate the heterogeneous diffusion dynamics behavior of transmembrane proteins within plasma membranes. We show that the experimentally observed two-step subdiffusion process can be described using fence and picket models combined with decreased local diffusivity of transmembrane proteins in the vicinity of the pickets. This allows us to explain the two-step subdiffusion behavior without explicitly introducing nested double compartments.
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Published Date | 2017-10-19
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Publication Title |
Physical review. E.
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Volume | volume96
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Issue | issue4-1
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Publisher | American Physical Society
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Start Page | 042410
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ISSN | 24700045
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NCID | AA11558033
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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File Version | publisher
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Related Url | isVersionOf https://doi.org/10.1103/PhysRevE.96.042410
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Citation | Numerical calculation on a two-step subdiffusion behavior of lateral protein movement in plasma membranes Tomonari Sumi, Atsushi Okumoto, Hitoshi Goto, and Hideo Sekino Phys. Rev. E 96, 042410
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Funder Name |
Japan Society for the Promotion of Science
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