ID | 61846 |
FullText URL | |
Author |
Morita, Takeshi
Graduate School of Science, Chiba University
Mukaide, Sayaka
Graduate School of Pharmaceutical Sciences, Chiba University
Chen, Ziqiao
Graduate School of Pharmaceutical Sciences, Chiba University
Higashi, Kenjirou
Graduate School of Pharmaceutical Sciences, Chiba University
Imamura, Hiroshi
College of Life Sciences, Ritsumeikan University
Moribe, Kunikazu
Graduate School of Pharmaceutical Sciences, Chiba University
Sumi, Tomonari
Research Institute for Interdisciplinary Science, Okayama University
ORCID
Kaken ID
publons
researchmap
|
Abstract | Polymeric micelles are invaluable media as drug nanocarriers. Although knowledge of an interaction between the micelles is a key to understanding the mechanisms and developing the superior functions, the interaction potential surface between drug-incorporated polymeric micelles has not yet been quantitatively evaluated due to the extremely complex structure. Here, the interaction potential surface between drug-entrapped polymeric micelles was unveiled by combining a small-angle scattering experiment and a model-potential-free liquid-state theory. Triblock copolymer composed of poly(ethylene oxide) and poly(propylene oxide) was investigated over a wide concentration range (0.5–10.0 wt %). Effects of the entrapment of a water-insoluble hydrophobic drug, cyclosporin A, on the interaction were explored by comparing the interactions with and without the drug. The results directly clarified the high drug carrier efficiency in terms of the interaction between the micelles. In addition, an investigation based on density functional theory provided a deeper insight into the monomer contribution to the extremely stable dispersion of the nanocarrier.
|
Keywords | polymeric micelle
drug entrapment
nanocarrier
interaction potential surface
small-angle X-ray scattering
model-potential-free liquid-state theory
|
Note | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.nanolett.0c03978 .
|
Published Date | 2021-01-22
|
Publication Title |
Nano Letters
|
Volume | volume21
|
Issue | issue3
|
Publisher | American Chemical Society (ACS)
|
Start Page | 1303
|
End Page | 1310
|
ISSN | 1530-6984
|
NCID | AA11511812
|
Content Type |
Journal Article
|
language |
English
|
OAI-PMH Set |
岡山大学
|
Copyright Holders | 2021 American Chemical Society
|
File Version | author
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
Related Url | isVersionOf https://doi.org/10.1021/acs.nanolett.0c03978
|
Funder Name |
Japan Society for the Promotion of Science
|