start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=正誤表 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設/岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設/岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=117 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=研究施設だより en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=116 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=事務部だより en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=115 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=看護部だより en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=98 end-page=107 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=業績集 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=2 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=岡山大学医学部環境病態研究施設報告の刊行について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=1 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=発刊に寄せる en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小田琢三 kn-aut-sei=小田 kn-aut-mei=琢三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部 END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=表紙・目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=18 end-page=23 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An application of artificial CO(2)-bathing for psychosomatic disorders in childhood kn-title=児童期心身症に対する人工炭酸浴の試み en-subtitle= kn-subtitle= en-abstract=The artificial CO(2)-bathing was prescribed for two girls with psychosomatic disorders. Case 1 was diagnosed as anorexia nervosa with self-injured wounds in the face and extremlties. Case 2 was diagnosed as trichotillomania with　self-injured wounds in the whole body. A tablet of 50g, made from sodium bicarbonate and succinic acid, was put in a bathtub of 150-200 litres at 40℃. Each patient was recommended to take a bath with her mother longer than at least 10 minutes. Both two cases became free from selfinjured wounds in about one week after the initiation of the artificial CO(2)-bathing, and gradually began to show positive 'Rapport' to the therapist. Underlying psychopathology and family dynamics were worked through the therapeutic sessions following the artificial CO(2)-bathing. It was suspected that the healing effect for wounds together with the relaxing effect for difficulty in interpersonal relationship with CO(2)-bathing, as a playful bubble bathing, resulted in successful outcome or both two cases． kn-abstract=人工炭酸浴剤浴（パブ浴）は，末梢循環改善作用を有して組織に賦活力を与え，皮膚創傷治癒を促進させる。全身に引き掻き傷を有する心身症の少女2症例に対して，母親とともにパブ浴を常用させた。何れの症例においても，皮膚創傷治癒をみて，患児，および母親に治療者を頼ってみようという，いわば治療への動機づけが促がされ，入浴という手段で児童の最大のストレスである母子関係の阻害に対し脱ストレス的に働き患児とのラポールがえられるようになった。パブ浴には副作用は全くなく，児童期の様々な心身症に応用されてよいであろう。 en-copyright= kn-copyright= en-aut-name=KomotoJunko en-aut-sei=Komoto en-aut-mei=Junko kn-aut-name=古元順子 kn-aut-sei=古元 kn-aut-mei=順子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院リハビリテーション部 en-keyword=人工炭酸浴 (Artitificial CO(2) bathing) kn-keyword=人工炭酸浴 (Artitificial CO(2) bathing) en-keyword=自傷 (seif-injured wounds) kn-keyword=自傷 (seif-injured wounds) en-keyword=創傷治癒効果 (healing effect for wounds) kn-keyword=創傷治癒効果 (healing effect for wounds) en-keyword=母子関係改善 (relaxing effect for mother-child relationship) kn-keyword=母子関係改善 (relaxing effect for mother-child relationship) en-keyword=あそび的効果 (play-therapeutic effect) kn-keyword=あそび的効果 (play-therapeutic effect) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=3 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effect of artificial CO(2) bathing on peripheral circulation insufficiency. kn-title=末梢循環障害への人工炭酸浴の効果 en-subtitle= kn-subtitle= en-abstract=Arteriography provides clear and useful information of ischemic leg anatomy. The method is limited, in that measurement of less than 100μ can not be made. The hemodynamics or functional consequences of the ischemic state should be evaluated by tissue circulation or perfusion methods that depend principally on systemic blood flow. Tissue perfusion is classified in two groups, insufficient and sufficient, depending on the type of clearance curve of PCO(2) in leg muscle following ankle exercise by means of medical mass spectrometry, Medspect Ⅱ, Chemetron, U.S.A. Either artificial CO(2) bathing or CO(2) vapour bath are efficacious for peripheral ischemic wound. Artificial CO(2) bathing is prepared with BUB-KAO 2tab., a 50g sodium hydrogen-carbonate and succinic acid tablet, Kao Co. Ltd. Japan, in 280-litre-tub at 40℃ for 20 minutes. CO(2) vapour bath is prepared with UKS CO(2) Trockengas Badkabine, Hansen Co., Ltd. West Germany, 20-litre-CO(2) per minutes at 40～42℃ for 20 minutes. In the case of insufficient tissue perfusion, ischemic wound is met promising outcome with CO(2) bathing even though no hope is expected with any medicine for peripheral circulation. Whereas, in the case of sufficient tissue perfusion, ischemic wound is expected much help of CO(2) bathing, as well as of all kinds of medicine, in healing process. kn-abstract=末梢動脈の慢性閉塞性疾患に対する血行再建術の予後は不良で，虚血肢の治療には一定の見解が乏しく非常に難澁するものである。組織循環の概念にもとづいた評価法によると，医用質量分析装置を用いた虚血肢運動負荷後のPtCO(2)の脱飽和曲線の型により組織循環の良否が定まる。組織循環の良好な型では，自然予後は良好で，いかなる保存的治療にもよく反応する。一方，組織循環の不良な型の自然予後は不良であるので，人工炭酸泉浴によるPtO(2)の増加，および組織循環量の改善により予後は良好となる。人工炭酸泉浴は，組織循環の良好な症例には治癒促進的に作用し，組織循環の不良な症例にも有効に作用する。 en-copyright= kn-copyright= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=1 ORCID= en-aut-name=KohmotoTomoji en-aut-sei=Kohmoto en-aut-mei=Tomoji kn-aut-name=河本知二 kn-aut-sei=河本 kn-aut-mei=知二 aut-affil-num=2 ORCID= en-aut-name=SunakawaMitsuru en-aut-sei=Sunakawa en-aut-mei=Mitsuru kn-aut-name=砂川満 kn-aut-sei=砂川 kn-aut-mei=満 aut-affil-num=3 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=4 ORCID= en-aut-name=EguchiYasuteru en-aut-sei=Eguchi en-aut-mei=Yasuteru kn-aut-name=江口泰輝 kn-aut-sei=江口 kn-aut-mei=泰輝 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=4 en-affil= kn-affil=花王株式会社栃木研究所 affil-num=5 en-affil= kn-affil=花王株式会社栃木研究所 en-keyword=人工炭酸浴 (Artificial CO(2) bath) kn-keyword=人工炭酸浴 (Artificial CO(2) bath) en-keyword=連浴 (serial bathing) kn-keyword=連浴 (serial bathing) en-keyword=末梢循環障害 (peripheral circuiation insufficiency) kn-keyword=末梢循環障害 (peripheral circuiation insufficiency) en-keyword=医用質量分析装置 (medical mass spectrometer) kn-keyword=医用質量分析装置 (medical mass spectrometer) en-keyword=組織循環 (tissue perfusion) kn-keyword=組織循環 (tissue perfusion) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=9 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Screening test for chromosome aberrations of long-time residents in misasa spa. kn-title=三朝温泉地長期入浴者の末梢血染色体におよぼす影響 en-subtitle= kn-subtitle= en-abstract=Screening test for chromosome aberrations of 13 long time residents, 9 native and 4 movingin in Misasa Spa was performed. Each Radon content in baths ranges 166-224 Bq/l, in homes 8.6-73.7 Bq/l, and in offices 8.4-22 Bq/l. Normal Karyotypes on both sexes and normal range of aberrations, gaps and breaks, were found in chromosome analyses. There are no significant radioactive effects from longtime bathings and from environment in both groups of Misasa spa districts, corresponding to the facts of no significant incidence of infertility, malformations, a brief span of life, and neoplasms compared to other places. kn-abstract=三朝温泉のラドン含有は，源泉で約1347～2694Bq／l，常用温泉水で137～224Bq／l，また，屋内では7.3～73.7Bq／lである。三朝温泉地に出生して，28～75年にわたる入浴者9名，および三朝温泉地外に出生して16～78 年にわたる入浴者4名について末梢静脈血の染色体検査を，ギムザ染色，および特に長年入浴している3名についてはG一分染法による分析を行なった。浴水，および生活環境のラドン濃度の多寡によらず，長年の入浴によっても染色体の構造変化は正常範囲内であった。 en-copyright= kn-copyright= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=1 ORCID= en-aut-name=KohmotoTomoji en-aut-sei=Kohmoto en-aut-mei=Tomoji kn-aut-name=河本知二 kn-aut-sei=河本 kn-aut-mei=知二 aut-affil-num=2 ORCID= en-aut-name=SunakawaMitsuru en-aut-sei=Sunakawa en-aut-mei=Mitsuru kn-aut-name=砂川満 kn-aut-sei=砂川 kn-aut-mei=満 aut-affil-num=3 ORCID= en-aut-name=YagiNobuko en-aut-sei=Yagi en-aut-mei=Nobuko kn-aut-name=矢木信子 kn-aut-sei=矢木 kn-aut-mei=信子 aut-affil-num=4 ORCID= en-aut-name=MifuneMasaaki en-aut-sei=Mifune en-aut-mei=Masaaki kn-aut-name=御船政明 kn-aut-sei=御船 kn-aut-mei=政明 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院中央検査部 en-keyword=三朝温泉地 (Misasa spa) kn-keyword=三朝温泉地 (Misasa spa) en-keyword=ラドン泉 (Radon bath) kn-keyword=ラドン泉 (Radon bath) en-keyword=染色体異常 (Chromosome aberration) kn-keyword=染色体異常 (Chromosome aberration) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=12 end-page=17 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical trials with artificial CO(2) bathings kn-title=内科疾患例に使用した人工炭酸浴剤浴の効果 en-subtitle= kn-subtitle= en-abstract=Clinical trials for 5 cases of peripheral circulation insufficiency, 2 cases of hypertension, 2 cases of general malaise and 2 cases of liver function insufficiency were performed with artificial CO(2) baths using BUB-KAO, a 50 g sodium hydogencarbonate and succinic acid tablet, KAO Co. Ltd., Japan, in 150-litre-tub at 40℃ for 10-20 minutes in a period of 6 to 12 months. By virtue of an increase of tissue PO(2) and an improvement of tissue perfusion with artificial CO(2) baths, favorable effects were obtained in all cases but in 2 patients with liver function insufficiency, leading to reduce or discontinue the regular medications. Remarkable effect was observed in 2 cases of hypertension, being brought under control in 2 months, keeping normal range thereafter due possibly to lowering the peripheral resistance caused by capillary dilation effect. A greate favor of hypotensive effect was granted in reducing the excretion of urinary protein. It is very advantageous in maintaining homeostasis to ameliorate natural course of diseases with artificial C (2) baths which are effective by repeated routine use for a long period of time, leading to assist modern way of medical treatment. kn-abstract=パブ浴（人工炭酸浴剤浴）は，組織に酸素を供給し，また組織循環の改善により組織に賦活力を与え，さらに末梢毛細血管の拡張作用を有する。外来患者を対象に，末梢循環障害5例，高血圧症2例，不定愁訴症例2例を選び，半年より1年にわたって家庭でパブ浴を連浴させた。全例に，併用薬の減量，あるいは中止をみた。とくに蛋白尿を伴った高血圧症例では，血圧の正常化に伴って蛋白尿の減少をみた。炭酸泉の効果は連浴によっても変化を認めず，人工炭酸泉浴は家庭においても療養泉としての効果がえられ，疾病の自然予後に有為に作用する。 en-copyright= kn-copyright= en-aut-name=UsuiYasuko en-aut-sei=Usui en-aut-mei=Yasuko kn-aut-name=薄井泰子 kn-aut-sei=薄井 kn-aut-mei=泰子 aut-affil-num=1 ORCID= en-aut-name=KomotoJunko en-aut-sei=Komoto en-aut-mei=Junko kn-aut-name=古元順子 kn-aut-sei=古元 kn-aut-mei=順子 aut-affil-num=2 ORCID= en-aut-name=SunakawaMitsuru en-aut-sei=Sunakawa en-aut-mei=Mitsuru kn-aut-name=砂川満 kn-aut-sei=砂川 kn-aut-mei=満 aut-affil-num=3 ORCID= en-aut-name=KohmotoTomoji en-aut-sei=Kohmoto en-aut-mei=Tomoji kn-aut-name=河本知二 kn-aut-sei=河本 kn-aut-mei=知二 aut-affil-num=4 ORCID= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=薄井医院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=人工炭酸泉浴 (Artificial CO(2) bath) kn-keyword=人工炭酸泉浴 (Artificial CO(2) bath) en-keyword=連浴 (serial bathing) kn-keyword=連浴 (serial bathing) en-keyword=末梢循環障害 (peripheral circulation insufficiency) kn-keyword=末梢循環障害 (peripheral circulation insufficiency) en-keyword=高血圧症 (hypertension) kn-keyword=高血圧症 (hypertension) en-keyword=不定愁訴 (general malaise) kn-keyword=不定愁訴 (general malaise) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=24 end-page=28 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of aging on pancreatic exocrine function -Aging and fecal chymotrypsin activity- kn-title=膵外分泌機能に及ぼす加齢の影響 ―加齢と糞便中キモトリプシン活性― en-subtitle= kn-subtitle= en-abstract=To examine the effect of aging on the pancreatic exocrine function, fecal chymotrypsin activity (FCA) was measured by the photometric method in 43 healthy controls, 39 controls in an old-age home and 41 patients with non-pancreatic diseases. Following conclusions were obtained. 1) Pancreatic exocrine function showed a significant decrease with aging as indicated by the present prospective study : ① a significantly lower FCA in the B group of 22 healthy controls (≧ 60 years of age) than the A group of 21 healthy controls (< 60 years of ago) ; ② significant correlationship between aging and FCA in the 43 healthy controls and also in the 41 patients with non-pancreatic diseases. 2) FCA in controls in an old-age home was especially low. Presumably it was due to their far-advanced aging. 3) The calculated lower limit of normal in FCA was 14.5U/g. However, the diagnosis of pancreatic diseases should not be coined solely on the basis of decreased FCA value. kn-abstract=膵外分泌機能に及ぼす加齢の影響を検討する目的で，健常人43名，非膵疾患患者41名，老人ホーム入居者39名を対象として比色法により糞便中キモトリプシン活性（FCA）を測定し，以下の結論を得た。1）FCAは逐齢的に低下し，60歳以上は60歳未満より有意の低値を示した。しかし，分布図のretrospectiveな検討からは，膵外分泌機能の低下は，実際には65～70歳あたりから明らかになることが示唆された。2）FCAの正常下限値を14.5U/gに定めたが，高齢者の診療にあたってはこの正常値のみを根拠にして疾病の有無を判定すべきではない。3）老人ホーム入居者のFCAは特に低値を取ったがその主要因は高齢者が多いためと考えられた。 en-copyright= kn-copyright= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=MorinagaHiroshi en-aut-sei=Morinaga en-aut-mei=Hiroshi kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=6 ORCID= en-aut-name=YoshidaMitsuo en-aut-sei=Yoshida en-aut-mei=Mitsuo kn-aut-name=吉田光雄 kn-aut-sei=吉田 kn-aut-mei=光雄 aut-affil-num=7 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=8 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=糞便中キモトリプシン活性 (Fecal chymotrypsin activity) kn-keyword=糞便中キモトリプシン活性 (Fecal chymotrypsin activity) en-keyword=加齢 (Aging) kn-keyword=加齢 (Aging) en-keyword=膵外分泌機能 (Pancreatic exocrine function) kn-keyword=膵外分泌機能 (Pancreatic exocrine function) en-keyword=膵 (Pancreas) kn-keyword=膵 (Pancreas) en-keyword=酵素 (Enzyme) kn-keyword=酵素 (Enzyme) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=29 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagnosis of chronic pancreatitis kn-title=慢性膵炎の診断 ―画像診断と機能検査の併用による― en-subtitle= kn-subtitle= en-abstract=Endoscopic retrograde cholangiopancreatography (ERCP), ultrasonography (US), computed tomography (CT), exocrine pancreatic function test (EX), endocrine pancreatic function test (EN), and analysis of pure pancreatic juice (PPJ) are currently available for the investigation of pancreatic diseases. The purpose of the present study is to evaluate the roles and preferable combinations of these tests in the diagnosis of chronic pancreatitis and then to propose a way to describe the results of the tests along with diagnosis for a better understanding of the disease process. Comparative studies of imaging, EX and EN led to the following conclusions. 1) imaging procedures (ERCP, US and CT) are mandatory, partly because they were frequently the test that showed diagnostic changes and partly because they often gave key information for operative treatment. Among the imaging procedures, ERCP combined with US and/or CT is mandatory because these combinations alone can reveal detailes of structural changes attendant on chronic pancreatitis. 2) EX is also mandatory, because it was occasionally the only test that showed diagnostic changes and partly because it often gave important information for medical treatment. 3) EN is also important, not because it was indispensable for detecting chronic pancreatitis, but because it often gave important information for medical treatment. For btter understanding of the disease process as well as diagnosis, we propose, as suggested by Seligson, that the test used for the establishment of the diagnosis and the degree as well as extent of abnormalities. An example is "Calcified chronic pancreatitis, alcoholic, diffuse, ERCP-3, US-2, CT-3, EX-2, EN-1, Lf(+)". This attitude will lead to a more rational approach to both diagnosis and treatment. kn-abstract=近年，各種膵疾患に対する検査法の発達には目を見張るものがあるが，実際の運用にあたっては各検査法の適応，限界，組合わせおよび実施する順序等に迷うことが少なくない。本研究では，最近我々が経験した慢性膵炎Ⅰ群116例の診断過程を振り返ることにより，慢性膵炎の診断における理想的な検査法の組合わせとそれぞれの役割を検討し，同時に診断名のみならず病態と病期が容易に理解できる表現方法を提案した。画像診断法，膵外分泌機能検査法（EX），膵内分泌機能検査法（EN）を比較検討し，以下の結果を得た。①画像診断法は必須である。②内視鏡的逆行性膵胆管造影（ERCP）を軸とした腹部超音波検査（US）あるいは腹部CTスキャン（CT）の組合わせは欠くことができない。③EXもまた必須の検査法である。④ENは慢性膵炎の診断に必要不可欠ではないが，治療方針を決めるうえで重要である。⑤純粋膵液（PPJ）の生化学的検査と組織化学的検査は膵炎の診断と病態生理の解明に重要である。⑥PPJ中の細胞診は慢性膵炎に合併した膵癌の検索に有用である。⑦以下に示すような診断の記載方法を提案した。"Calcified chronic pancreatitis, alcoholic, diffuse,　ERCP-3, US-2, CT-3, EX-2, EN-1, Lf(＋)"。 en-copyright= kn-copyright= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=YoshidaMitsuo en-aut-sei=Yoshida en-aut-mei=Mitsuo kn-aut-name=吉田光雄 kn-aut-sei=吉田 kn-aut-mei=光雄 aut-affil-num=6 ORCID= en-aut-name=OkaHiroo en-aut-sei=Oka en-aut-mei=Hiroo kn-aut-name=岡浩郎 kn-aut-sei=岡 kn-aut-mei=浩郎 aut-affil-num=7 ORCID= en-aut-name=MiyakeHirofumi en-aut-sei=Miyake en-aut-mei=Hirofumi kn-aut-name=三宅啓文 kn-aut-sei=三宅 kn-aut-mei=啓文 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=7 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) en-keyword=画像診断 (imaging diagnosis) kn-keyword=画像診断 (imaging diagnosis) en-keyword=PS試験 (pure pancreatic juice) kn-keyword=PS試験 (pure pancreatic juice) en-keyword=純粋膵液(PPJ) (Pancreozymin-Secretin test) kn-keyword=純粋膵液(PPJ) (Pancreozymin-Secretin test) en-keyword=内視鏡的逆行性膵胆管造影(ERCP) (endoscopic retrograde cholangiopancreatography (ERCP)) kn-keyword=内視鏡的逆行性膵胆管造影(ERCP) (endoscopic retrograde cholangiopancreatography (ERCP)) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=37 end-page=41 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy for bronchial asthma. Annual changes of characteristics of asthmatics admitted during the past four years. kn-title=気管支喘息の温泉療法 ―対象症例の年次推移― en-subtitle= kn-subtitle= en-abstract=Annual changes of characteristics, sex, area (Prefecture) of patients' coming from, term of admission, clinical classification of asthma and use of glucocorticoids, were examined in 45 patients with bronchial asthma who were admitted at Misasa Hospital, Okayama University Medical School and received spa therapy during the past four years from 1982 to 1985. In the first two years from 1982 to 1983, more patients with bronchial asthma were admitted from Okayama Prefecture, and the majority of them had severe asthma attacks and were more dependent on steroid-therapy. On the other hand, in the past two years from 1984 to 1985, number of patients with bronchial asthma from Tottori Prefecture increases, and their attacks were less severe and less dependent on steroid-therapy compared to the patients admitted during the first two years. Term of admission became shorter in the past two years than in the first two years. Any differences between the first and the past two years were not shown in sex, patient age and asthma types classified by clinical symptoms. kn-abstract=1982年1月から1985年12月までの4年間に三朝分院内科へ入院し，温泉療法を受けた気管支喘息45例を対象にその年次推移を検討した。1．性別：初期2年間は男性の入院症例が多い状況であったが，後期2年間では男女比はほぼ等しかった。2．年令：年次推移はみられず，その平均年令は50±2才の間にあった。3．地域分布：初期2年間は岡山県からの入院症例が多数をしめたが，後期2年間ではむしろ鳥取県からの入院症例が増加する傾向がみられた。4．入院期間：初期2年間の平均入院期間は6.7カ月，6.5カ月とかなり長くなる傾向がみられたが，後期2年間ではそれぞれ3.0カ月，1.5カ月と明らかな短縮傾向がみられた。5．臨床病型：いずれの年度においても重症化傾向の強いⅠb型，Ⅱ型が多くみられたが，各年度間には差はみられなかった。6．ステロイド剤使用状況：年度の経過とともにその使用量は減少して いく傾向が示された。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=2 ORCID= en-aut-name=KomagoeHaruki en-aut-sei=Komagoe en-aut-mei=Haruki kn-aut-name=駒越春樹 kn-aut-sei=駒越 kn-aut-mei=春樹 aut-affil-num=3 ORCID= en-aut-name=MorinagaHiroshi en-aut-sei=Morinaga en-aut-mei=Hiroshi kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設基礎環境病態学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=温泉療法 (spa therapy) kn-keyword=温泉療法 (spa therapy) en-keyword=臨床病型 (asthma type) kn-keyword=臨床病型 (asthma type) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=42 end-page=45 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on anti-allergic actions of tranilast (Rizaben®) kn-title=Tranilast(Rizaben®)の抗アレルギー作用について en-subtitle= kn-subtitle= en-abstract=Tlanilast is clinically used for bronchial asthma as one of the prophylactic agents for asthma attacks. In this study, anti-allergic actions of tranilast were examined in (45)Ca uptake of and histamine release from target cells of IgE after stimulation with antigen, anti-IgE and camp. 48/80. 1. (45)Ca uptake of and histamine release from rat peritoneal mast cells stimulated by antigen were significantly inhibited by preincubation of the cells with tranilast. Inhibition by tranilast of increased (45)Ca uptake of mast cells by addition of phosphatidylserine were less, although inhibition of histamine release was not so affected by addition of phosphatidylserine. No significant inhibition by tranilast of (45)Ca uptake and histamine release was not observed when the cells were stimulated by camp. 48/80. 2. Tranilast showed any inhibitory effects on basophil histamine release induced by antigen and anti-IgE. kn-abstract=抗アレルギー剤（脱顆粒抑制剤）の1つであるtranilastの肥満細胞の遊離機序に対する抑制作用について検討を加えた。1．抗原刺激時の肥満細胞の(45)Ca uptakeおよびヒスタミン遊離に対して，tranilastは有意の抑制作用を示したが，comp.48/80刺激時にはtranilastの(45)Ca uptake，ヒスタミン遊離に対する抑制作用はほとんどみられなかった。2．phosphatidylserine添加時には，(45)Ca uptakeに対するtranilastの抑制作用は減弱傾向を示し，この傾向はヒスタミン遊離に対する作用に比べより高度であった。3．抗原および抗ヒトIgEによる好塩基球からのヒスタミン遊離に対して，tranilastは明らかな抑制作用を示さなかった。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KomagoeHaruki en-aut-sei=Komagoe en-aut-mei=Haruki kn-aut-name=駒越春樹 kn-aut-sei=駒越 kn-aut-mei=春樹 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=3 ORCID= en-aut-name=MorinagaHiroshi en-aut-sei=Morinaga en-aut-mei=Hiroshi kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=4 ORCID= en-aut-name=OhtaniJun en-aut-sei=Ohtani en-aut-mei=Jun kn-aut-name=大谷純 kn-aut-sei=大谷 kn-aut-mei=純 aut-affil-num=5 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設基礎環境病態学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=6 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=トラニラスト (tranilast) kn-keyword=トラニラスト (tranilast) en-keyword=(45)Ca取り込み ((45)Ca uptake) kn-keyword=(45)Ca取り込み ((45)Ca uptake) en-keyword=ヒスタミン遊離 (histamine release) kn-keyword=ヒスタミン遊離 (histamine release) en-keyword=肥満細胞 (mast cell) kn-keyword=肥満細胞 (mast cell) en-keyword=好塩基球 (basophils) kn-keyword=好塩基球 (basophils) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=S1 end-page=S96 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=森永教授退官記念特集 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=46 end-page=55 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on sinter deposits of misasa radioactive hot springs (3RD report) kn-title=三朝温泉水配管内の温泉沈殿物について（第3報）（付三朝分院飲泉水分析） en-subtitle= kn-subtitle= en-abstract=The hot spring waters of Okadaisen and the sinter deposit in the distributing pipe which was used for about 20 years were investigated. The analysis of the spring waters and the sediment were mainly carried out by Spectraspan emission spectrophotometer. Radium-226 in the sinter deposit and radon-222 in the spring waters were measured by vibrating reed electrometer and liquid scintillation counter, respectively. As the results of the analysis, this spring waters were classified into weakly radioactive sodium-chloride waters. It also contained 3.73mg/kg of F and 190.9 Bq./kg of radon-222. The major components of this deposit were characterized with regard to high concentration of Mn (363.5mg/g), Fe (148.0mg/g), and Ba (69.6mg/g). Ra-226 concentration of the sinter deposits of Misasa hot springs in previous reports were 6.24×10(-12)～5.74×10(-8) (Ci/g), but its concentration in this report was 3.30×10(-8) Ci/g. It seems that a linear correlation is recognized between radium-226 and (Fe+Mn) concentrations in the sinter dedosits of Misasa hot springs. kn-abstract=鳥取県三朝温泉岡大源泉の配湯管内の温泉沈殿物について既に報告されているが，今回採取した黒色の温泉沈殿物について発光分析法による定性分析を行ったところ，強放射性鉱物である北投石の主成分のBaが高濃度に検出されたので，岡大源泉（飲泉）水および沈殿物中の主要成分および放射能について調査した。温泉水のpHは6.97，Rn-222濃度は190.9Bq./kgで，Mn，Fe，Baの濃度は夫々0.011，0.018，0.021（mg/kg）であり，泉質は弱放射能-ナトリウム-塩化物泉に該当した。沈殿物中の主要成分はMn，Fe，Baで，その濃度は夫々363.5，148.0，69.6mg/gであり，このBa濃度は三朝温泉の温泉沈殿物中最高の濃度であった。しかしRa-226濃度は，既報程 度の3.30×10(-8)Ci/kgであった。 en-copyright= kn-copyright= en-aut-name=MifuneMasaaki en-aut-sei=Mifune en-aut-mei=Masaaki kn-aut-name=御船政明 kn-aut-sei=御船 kn-aut-mei=政明 aut-affil-num=1 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院中央検査部 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 en-keyword=三朝温泉 (Misasa hot springs) kn-keyword=三朝温泉 (Misasa hot springs) en-keyword=温泉沈殿物 (Thermal sinter deposits) kn-keyword=温泉沈殿物 (Thermal sinter deposits) en-keyword=バリウム (Barium) kn-keyword=バリウム (Barium) en-keyword=ラジウム (Radium) kn-keyword=ラジウム (Radium) en-keyword=ラドン (Radon) kn-keyword=ラドン (Radon) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=56 end-page=60 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Angiography system combined with Toshiba BV type X-TV equipment. 1. Whole limb serial aort-arteriography kn-title=東芝BV型XTV装置を併用したANGIO graphy systemの使用経験（第1報　下肢連続撮影装置） en-subtitle= kn-subtitle= en-abstract=A whole-limb serial aort-arteriography system constituted of BV-type X-TV and extralarge film changer was developed and used clinically. The results were as foll-ows. 1. By improving functions of the board of TV table, changes from fluoroscopy to radiography became easier in whole limb serial aort-arteriography. 2. By using LS-Ⅱ screen and 1.0cm edge filter, we could get well compensated X-ray photographs. kn-abstract=消化管診断用X線TV装置の天板機能を改良し，種々のフィルムチェンジャー，X線管球を組み合わせることにより，中規模病院において，スペース，経費などの点で有利な，血管造影システムを組むことができた。第1報では，このうち，下肢連続撮影システムについて紹介する。1．透視から造影まで，迅速に移行できるシステムとなった。2．スペース，経費の点で有利である。3．濃度補償については，LS-Ⅱ増感紙と，1.0cmエッジフィルターにより，体型によらず，全下肢にわたり，十分な補償効果が得られる。4．さらに長い長尺カセッテの開発が望まれる。 en-copyright= kn-copyright= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=1 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=2 ORCID= en-aut-name=MatsushimaKishio en-aut-sei=Matsushima en-aut-mei=Kishio kn-aut-name=松島紀志夫 kn-aut-sei=松島 kn-aut-mei=紀志夫 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院放射線部 en-keyword=全下肢連続動脈造影 (whole-limb serial aort-arteriography) kn-keyword=全下肢連続動脈造影 (whole-limb serial aort-arteriography) en-keyword=長尺フィルムチェンジャー (extra-large-film changer) kn-keyword=長尺フィルムチェンジャー (extra-large-film changer) en-keyword=X-TV台天板 (the board of TV table)　 kn-keyword=X-TV台天板 (the board of TV table)　 en-keyword=濃度補償 (compensation of density) kn-keyword=濃度補償 (compensation of density) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=61 end-page=66 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Angiography system combined with Toshiba BV-type X-TV Equipment. 2. Stereo-magnification system. kn-title=東芝BV型XTV装置を併用したANGIO graphy systemの使用経験（第2報　立体拡大撮影システム） en-subtitle= kn-subtitle= en-abstract=Angiography of the head and abdominal region gives a good deal of peculiar information for the diagnosis of nature of pathological lesions. When angiography could be performed by stereo-magnification radiography, the radiography gives better information for physicians. In this article, we tried angiography by the stereomagnifying radiography system utilizing X-TV equipment for examination of digestive system. 1. To magnify film image, the film changer was modified to move up and down, because the board of TV table did not change vertically. The board of TV table was also modified to slide more widely. The modifications could make it possible to magnify the film image by two times. 2. To use the X-TV equipment brought some advantages as follows it became very easy for us to convert the X-TV system from fluoroscopy to radiography, and contact seriography was easily changed to stereo-magnification seriography. kn-abstract=我々は，既設の消化管診断用X線TV装置（東芝BV型）を使用した立体拡大撮影システムを検討した。1．消化管診断用X線TV装置の透視天板の高さが一定であるため，従来のフィルムチェンジャー（AOT）では不可能であったが，上下動可能なフィルムチェンジャー（福放FC-10L特）を改良試作したことで最大2倍までの立体拡大撮影が可能となった。2．透視観察から撮影へ，コンタクト撮影から拡大連続撮影，立体撮影から立体拡大連続撮影へと併用して行うことが非常に簡単にできて被検者の負担軽減と多目的使用が可能となった。3．観察条件と立体感については，拡大率を変化させて，その立体感について検討した結果は、観察距離については，各拡大率における立体視しやすい距離は存在し，拡大率が2倍の場合には，観察距離を大きくするほど立体感も増加し，立体視し易い傾向が示された。 en-copyright= kn-copyright= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=1 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=2 ORCID= en-aut-name=MatsushimaKishio en-aut-sei=Matsushima en-aut-mei=Kishio kn-aut-name=松島紀志夫 kn-aut-sei=松島 kn-aut-mei=紀志夫 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院放射線部 en-keyword=立体拡大撮影 (Stereo-magnification radiography) kn-keyword=立体拡大撮影 (Stereo-magnification radiography) en-keyword=フィルム連続撮影装置 (Fiim changer) kn-keyword=フィルム連続撮影装置 (Fiim changer) en-keyword=立体感 (Stereoscopic image) kn-keyword=立体感 (Stereoscopic image) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=67 end-page=97 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=on climatology in misasa spa (eighth report) kn-title=三朝温泉地の気候について（第8報） en-subtitle= kn-subtitle= en-abstract=Climatological data of the last fifteen months (1984.1.1.-1985.3.31.) obtained at the observatory in the Misasa Branch Hospital of Okayama University Hospital at Misasa Spa, Tottori-Ken, Japan are presented. kn-abstract=われわれは1956年1月以降，三朝温泉地の気侯要素の観測を行ってきているが，今回は第8報として，1984年1月1日から1985年3月末日までの15カ月の気象観測の資料を報告することとした。1985年4月1日以降は自動記録装置が備えられたので，3月末日までとした。 en-copyright= kn-copyright= en-aut-name=InoueTaeko en-aut-sei=Inoue en-aut-mei=Taeko kn-aut-name=井上妙子 kn-aut-sei=井上 kn-aut-mei=妙子 aut-affil-num=1 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=2 ORCID= en-aut-name=MorinagaHiroshi en-aut-sei=Morinaga en-aut-mei=Hiroshi kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=108 end-page=111 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=前背髄動脈症候群のリハビリテーション en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山田武司 kn-aut-sei=山田 kn-aut-mei=武司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院リハビリテーション部 END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=112 end-page=112 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=第13回喘息児童の夏期教室へ参加して en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山田香須美 kn-aut-sei=山田 kn-aut-mei=香須美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page=113 end-page=114 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=1600Kcalの食事を試食して en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中村寿美江 kn-aut-sei=中村 kn-aut-mei=寿美江 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=石湯和子 kn-aut-sei=石湯 kn-aut-mei=和子 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=谷本悦子 kn-aut-sei=谷本 kn-aut-mei=悦子 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=198607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=投稿規程 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=66 end-page=68 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=気管支喘息のリハビリテーションとアンケート調査結果 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山田武司 kn-aut-sei=山田 kn-aut-mei=武司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=リハビリテーション部 END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=12 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of spa-drink therapy on exocrine pancreatic function kn-title=膵外分泌機能におよぼす飲泉の効果 en-subtitle= kn-subtitle= en-abstract=The effect of spa-drink therapy (Misasa hot spring) on exocrine pancreatic function was studied on 18 patients after their physical and psychological conditions were stabilized about two weeks following hospitalization. Patients were randomly divided into two groups : eight patients into a control group (continuance of spa-bathing) and 10 patients into a spa-drink therapy group (continuance of spa-bathing plus commencement of spa-drink therapy). Spa-drink therapy refers to drinking 200mℓ of warm spa-water (42℃) two times a day : between meals in the morning and in the afternoon. Exocrine pancreatic function was evaluated by fecal chymotrypsin activity, using a colorimetric method (Boehringer-Mannheim). Following results were obtained : 1) With 2-week's spa-drink therapy, fecal chymotrypsin activity was significantly enhanced in 40 % of the patients, while none of the controls showed an increase in fecal chymotrypsin activity. 2) Fecal chymotrypsin activity at the time of 4 weeks was similar to that obtained at the time of 2 weeks in both groups. In conclusion, spa-drink therapy for 2 weeks was effective for the enhancement of exocrine pancreatic function. kn-abstract=膵外分泌機能におよぼす飲泉（三朝温泉水）の効果を飲泉群および非飲泉群を対象として検討した。膵外分泌機能検査法としては，糞便中キモトリプシン活性比色測定法（モノテストカイモトリプシン）を用いた。その結果，糞便中キモトリプシン活性は，飲泉開始2週後に40　％　の患者で上昇し，4週後は2週後と変わらなかった。以上より，2週間の飲泉は膵外分泌機能を改善させる効果があることがわかった。 en-copyright= kn-copyright= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=SenouToshinobu en-aut-sei=Senou en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=6 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=7 ORCID= en-aut-name=IshibashiTadaaki en-aut-sei=Ishibashi en-aut-mei=Tadaaki kn-aut-name=石橋忠明 kn-aut-sei=石橋 kn-aut-mei=忠明 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=8 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=糞便中キモトリプシン活性 (Fecal chymotrypsin activity) kn-keyword=糞便中キモトリプシン活性 (Fecal chymotrypsin activity) en-keyword=飲泉療法 (Spa-drink therapy) kn-keyword=飲泉療法 (Spa-drink therapy) en-keyword=膵外分泌機能 (Pancreatic exocrine function) kn-keyword=膵外分泌機能 (Pancreatic exocrine function) en-keyword=膵 (Pancreas) kn-keyword=膵 (Pancreas) en-keyword=酵素 (Enzyme) kn-keyword=酵素 (Enzyme) END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=1 end-page=4 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Short term effect of spa-water on gastric mucosal blood flow kn-title=胃粘膜血流に及ぼす温泉水の効果 en-subtitle= kn-subtitle= en-abstract=Short-term effects of spa-drink therapy on gastric mucosal blood flow were evaluated by an endoscopic organ reflex spectrophotometry, using Olympus XQ-10. Thirty-four subjects were randomly divided into three groups : 10 subjects for warm spa-water (40±C) infusion group, 10 subjects for warm tap-water infusion group, and 14 subjects for warm air infusion group. Intragastric infusion of water or air was performed through the fiberscopic infusion channel. Gastric mucosal blood flow was determined just before and 10 min after the infusion on the three points of gastric mucosa : lesser curvature of the angle, the antrum and the pylorus. Following results were obtained : 1) Spa-water exerted a beneficial effect on gastric mucosal blood flow as compared to air. The difference was statistically significant on all of the three points. 2) Spa-water tended to exert a beneficial effect on gastric mucosal blood flow as compared to tap-water. The difference, however, was significant only on the mucosa of the gastric antrum. In conclusion, it was suggested that spa-drink therapy was useful for the treatment of chronic gastritis and gastric ulcer in which impairment of gastric mucosal blood flow plays an important pathogenetic role. Studies on the long-term effects of spa-drink therapy on the gastric mucosal blood flow are now in progress. kn-abstract=臓器反射スペクトル法と内視鏡を併用して胃粘膜血流を測定し，当院温泉水飲用の消化機能に対する基礎的検討を胃粘膜血流を指標に行なった。温泉水の対照として空気と白湯を選び3群に分け検討した。その結果，温泉水は空気に比し胃粘膜血流を増加させる作用を有していることが示唆された。また温泉水は部分的ではあるが白湯にくらべても胃粘膜血流を増加させる作用があることが示唆された。よって飲泉療法の消化器疾患に対する臨床的有用性が胃粘膜血流の面からもうかがわれた。 en-copyright= kn-copyright= en-aut-name=TanakaJuntarou en-aut-sei=Tanaka en-aut-mei=Juntarou kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=1 ORCID= en-aut-name=MatumotoShuuji en-aut-sei=Matumoto en-aut-mei=Shuuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=2 ORCID= en-aut-name=SenouToshinobu en-aut-sei=Senou en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=3 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=4 ORCID= en-aut-name=OchiKouji en-aut-sei=Ochi en-aut-mei=Kouji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=5 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=6 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学部門 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学部門 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学部門 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学部門 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学部門 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学部門 affil-num=7 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学部門 en-keyword=飲泉療法 (Spa-drink therapy) kn-keyword=飲泉療法 (Spa-drink therapy) en-keyword=消化器機能 (Digestive function) kn-keyword=消化器機能 (Digestive function) en-keyword=胃粘膜血流 (Gastric mucosal blood flow) kn-keyword=胃粘膜血流 (Gastric mucosal blood flow) en-keyword=臓器反射スペクトル法 (Organ reflex spectrophotometry) kn-keyword=臓器反射スペクトル法 (Organ reflex spectrophotometry) END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=5 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on anti-allergic action of Terfenadine kn-title=Terfenadineの抗アレルギー作用について en-subtitle= kn-subtitle= en-abstract=Anti-allergic action of terfenadine, one of the H(1) receptor inhibitors, was examined by human basophil histamine release induced by anti-IgE or a specific allergen (house dust), and the release of leukotriens from leucocytes stimulated by Ca ionophore A23187. 1. Terfenadine did not inhibit the release of histamine from basophils of healthy subjects induced by anti-IgE, and also of patients with bronchial asthma induced by house dust when the in vitro examination was performed by a whole blood method. 2. Histamine release from basophils of patients with bronchial asthma was significantly inhibited when washed leucocytes was preincubated with terfenadine in vitro. The release of LT B(4) from leucocytes was also inhibited. 3. In vivo examination of inhibitory action of terfenadine showed no effect on basophil histamine release of healthy subjects by anti-IgE and of asthmatic subjects by house dust, although skin test by house dust in these subjects was inhibited 60 min after administration in vivo. These results show that terfenadine inhibits the release of chemical mediators from tissue mast cells, and basophils migrating into local allergic sites. kn-abstract=選択的H(1)受容体拮抗薬であるTerfenadineの抗アレルギー作用，特にIgE系反応によるヒスタミン，およびCa ionophore A23187による好中球からのleukotrienes遊離に対する抑制作用を，ヒト末梢血白血球を用いて検討した。１．Terfenadineは，抗ヒトIgE刺激による健康人好塩基球および特異抗原刺激による気管支喘息患者好塩基球からのヒスタミン遊離に対して，全血法でのin vitro添加実験では有意の抑制作用を示さなかった。 2．洗浄白血球法によるin vitro添加実験では，Terfenadineは特異抗原および抗ヒトIgE刺激時の気管支喘息患者好塩基球からのヒスタミン，Ca ionophore　A23187刺激時のleukotriene B(4)遊離に対して有意の抑制効果を示した。3．Terfenadineの内服によるin vivoの抑制実験では，IgE系反応による健康人および気管支喘息患者好塩基球からのヒスタミン遊離に対して有意の抑制効果は見られなかったが，特異抗原による皮膚反応に対しては明らかな抑制作用が観察された。以上より，Terfenadineは，組織肥満細胞および組織へと遊走してきた好塩基球に対してはある程度の抑制作用を有しているものと考えられた。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KomagoeHaruki en-aut-sei=Komagoe en-aut-mei=Haruki kn-aut-name=駒越春樹 kn-aut-sei=駒越 kn-aut-mei=春樹 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=3 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部三朝分院内科 en-keyword=夕一フェナンジン (Terfenadine) kn-keyword=夕一フェナンジン (Terfenadine) en-keyword=lgE系反応 (IgE-mediated reaction) kn-keyword=lgE系反応 (IgE-mediated reaction) en-keyword=ヒスタミン (histamine) kn-keyword=ヒスタミン (histamine) en-keyword=好塩基球 (basophils) kn-keyword=好塩基球 (basophils) END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=17 end-page=21 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The simplified method of measuring Radon in mineral waters by the liquid scintillation counter. kn-title=液体シンチレーション計数器を用いるRn-222の簡易定量法 en-subtitle= kn-subtitle= en-abstract=Radon in mineral waters was determined with simplicity by newly developed method. In this method, 2.0mℓ of water sample was directly mixed with 15 mℓ of Hionic-Fluor in a vial, which was then filled up with additional Hionic-Fluor ; 190 minutes were allowed for the radioactivity to equilibrate. The radioactiviity of Radon was measured by the Liquid Scintillation Counter (Tri-Carb 460C). Radon content was easily calculated with the proposed formula by an electric desk calculater. The reproducibility was proved CV=5.77 % ; the lowest detection limit was 0.2 nCi/l. An adequate correlation was obtained from the results of measurements compared with the original method ; r=0.996, y=0.818x×0.875. kn-abstract=鉱泉水中のラドンを測定するため，抽出法を省略し，少量の試料水を直接液状シンチレーターに溶解し，液体シンチレーション計数器を用いて放射能を測定し，次いで簡単な計算法により試料水中のラドン濃度を計算する簡易定量法を試みた。本法を用いて一鉱泉水のラドンを反復測定した際の精度は，σ＝0.136nCi/l，CV＝5.77　％　，（x＝2.36n　Ci/l）であった。次に本法でのRnの最少検出量は，0.2nCi/lである。原法と本法とを用いて得られた測定値の間には，r＝0.996，y＝0.818x＋0.875なる相関関係が成立した。本法を使用すると，簡単な予備処理後，極短時間内にラドンの測定が可能なため，花崗岩地域の井水，鉱泉水中のラドンを定量するためには，有用な方法である。 en-copyright= kn-copyright= en-aut-name=MifuneMasaaki en-aut-sei=Mifune en-aut-mei=Masaaki kn-aut-name=御舩政明 kn-aut-sei=御舩 kn-aut-mei=政明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院中央検査部 en-keyword=鉱泉水 (Mineral waters) kn-keyword=鉱泉水 (Mineral waters) en-keyword=ラドン (Radon) kn-keyword=ラドン (Radon) en-keyword=放射能泉 (Radioactive springs) kn-keyword=放射能泉 (Radioactive springs) en-keyword=液体シンチレーション計数器 (Liquid scintillation counter) kn-keyword=液体シンチレーション計数器 (Liquid scintillation counter) END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=22 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical effects of serial artificial CO(2) baths on degenerative disorders in consideration of the improved tissue perfusion. kn-title=人工炭酸泉連浴による微小循環改善の退行性病変に対する効果 en-subtitle= kn-subtitle= en-abstract=Tissue perfusion plays an important role in prognosis of the deteriorating connective tissue disorders. Tissue perfusion was evaluated before and after CO(2) treatment on the patients with connective tissue disorders by means of medical mass spectrometer. CO(2) treatment was performed in 2 ways ; one was with CO(2)-cabine, 20 litres per minute at 40℃ for 20 minutes, and the other was with an artificial CO(2) bathing prepared with 2 tablets of BUB-KAO, a 50 g sodium hydrogencarbonate and succinic acid tablet, in 280-litre-tub at 40℃ for 20 minutes. Case 1, 33-year-old female, suffering from chronic rheumatic arthritis with rheumatic thromboangiitis obliterans in the left 5th toe. Main arterial trees were found intact arteriographically. Her joint pain and muscle stiffness have been improved markedly after CO(2) treatment with cabin every day for one month though every medicine for rheumatism made little effect. Case 2, 46-year-old female, suffered from progressive systemic scleroderma. Major blood supply was found not blocked in upper extremities arteriographically. Tissue perfusion was found poor in muscle tissue of each forearm before CO(2) treatment with cabin, whereas an improved tissue perfusion was confirmed after one month of serial CO(2) treatment, leading to ameliorate persistent muscle stiffness, though every medicine for her made slow effect. Case 3, 48-year-old female, suffering from the weakness in strength with no positive laboratory findings of connective tissue disorders. Tissue perfusion has been found quite improved following serial artificial CO(2) bathings for 12 months, being able to work hard every day as a nurse. Serial CO(2) bathing is thought to be very useful in ameliorating the symptoms of deteriorating connective disorders by virtue of an improved tissue perfusion. kn-abstract=組織循環の良不良は，結合織の退行性病変の予後に大いに影響をおよぼすものである。人工炭酸泉を用いた実験的検討で，すでに組織循環の30　％　増加を認めており，臨床的治験により好傾向を示す結果を得つつある。結合織病変を主とする慢性疾患4症例の治験前後に局所組織流量を測定して評価することができた。局所組織流量は医用質量分析装置を介したオンラインシステムで測定計算した。人工炭酸浴は，炭酸ガスキャビン，および人工炭酸浴剤浴を用いた。人工炭酸泉浴は，1カ月より1年におよび，それぞれ自覚症状の著名な改善と，組織流量の増加を定量しえた。人工炭酸泉の連浴による組織流量の改善は、結合織の退行性病変に有効に作用するものである。 en-copyright= kn-copyright= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=1 ORCID= en-aut-name=KohmotoTomoji en-aut-sei=Kohmoto en-aut-mei=Tomoji kn-aut-name=河本知二 kn-aut-sei=河本 kn-aut-mei=知二 aut-affil-num=2 ORCID= en-aut-name=SunakawaMitsuru en-aut-sei=Sunakawa en-aut-mei=Mitsuru kn-aut-name=砂川満 kn-aut-sei=砂川 kn-aut-mei=満 aut-affil-num=3 ORCID= en-aut-name=YagiNobuko en-aut-sei=Yagi en-aut-mei=Nobuko kn-aut-name=矢木信子 kn-aut-sei=矢木 kn-aut-mei=信子 aut-affil-num=4 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=5 ORCID= en-aut-name=MatsumotoYasunobu en-aut-sei=Matsumoto en-aut-mei=Yasunobu kn-aut-name=松本泰伸 kn-aut-sei=松本 kn-aut-mei=泰伸 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=5 en-affil= kn-affil=花王株式会社栃木研究所 affil-num=6 en-affil= kn-affil=花王株式会社栃木研究所 END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=31 end-page=34 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy for bronchial asthma 1. Climatotherapy, its clinical effects kn-title=喘息の温泉療法1．気候療法，その臨床効果 en-subtitle= kn-subtitle= en-abstract=Spa therapy includes influence of environmental factors, especially climate around the place at which spa therapy is performed. In the present article, the effects of environmental climate around the hot springs on bronchial　asthma were discussed according to the reports published. Mountain climate, sea climate and underground climate are reported to be effective for the therapy of bronchial asthma. Although these climates have shown remarkable effectiveness on bronchial asthma, each of them has climatic characteristics in treatment for bronchial asthma． Mountain climate has low content of oxygen and low vapor pressure, and patients with bronchial asthma require several weeks to adapt themselves for the climate. Sea climate is rich in cations and anions, and Ca(2+) and Mg(2+) included in sea water aerosol act beneficially on mucous membrane of airways in patiepts with bronchial asthma. Underground climate includes a lot of anions, which activate the activity of mucous membrane and ability of clearance of airways. Each climate also activate the function of adrenal glands． kn-abstract=気管支喘息に対する温泉療法，特に温泉所在地（保養地）の環境，すなわち気候条件の喘息に対する影響について，文献的考察を加えた。気候療法としては，主として山岳気候，海洋性気候，洞窟気候などが，喘息の治療に応用されている。これらの気候は，いずれも喘息に対して有効的に作用することが示されているが，それぞれの特徴を持っている。例えば，山岳気候は酸素分圧が低いこと，水蒸気圧が低いことなどが特徴であり，そのため生体がそれに適合するためにはある程度の時間が必要となる。一方海洋性気候は，海塩粒子を含んでおり，海水エロゾル中のカルシウムやマグネシウムなどが良い影響を与えると考えられている。また洞窟気候は，水分含量が均一であり，電解質，特に陰イオンが多く，これが粘膜活性や浄化活性を亢進させると言われている。またいずれの気候療法も，副腎皮質機能の活性化をもたらすと考えられている。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 en-keyword=気候療法 (climatotherapy) kn-keyword=気候療法 (climatotherapy) en-keyword=気管支喘息 (bronchial asthrna) kn-keyword=気管支喘息 (bronchial asthrna) en-keyword=山岳気候 (mountain climate) kn-keyword=山岳気候 (mountain climate) en-keyword=海洋性気候 (sea climate) kn-keyword=海洋性気候 (sea climate) en-keyword=洞窟気候 (underground climate) kn-keyword=洞窟気候 (underground climate) END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=35 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy for bronchial asthma 2. Clinical and fundamental evaluation procedures kn-title=喘息の温泉療法2．臨床的並びに基礎的評価方法 en-subtitle= kn-subtitle= en-abstract=Evaluation procedures for effectiveness of spa therapy on bronchial asthma were discussed according to the reports published. The evaluation procedures could be divided into tow groups : procedures by clinical observations and procedures by findings relating to action mechanisms of spa therapy. Clinical evaluations have been performed by subjective and objective symptoms, the degree of reduction of drugs used for treatment of bronchial asthma, and improvement of each parameter in ventilatory function test. The results obtained by these procedures are frequently reported as clinical observations. On the other hand, evaluations based on the findings relating to action mechanisms of spa therapy have been carried out as follows : 1) observations for immuno-allergic reactions which play an important role in pathogenic mechanisms of bronchial asthma. 2) observations for autonomic nerve system, and 3) for endocrine glands, which have a close correlation with onset mechanisms of bronchial asthma. The results obtained by these findings before and after spa therapy are much interesting, and should be investigated furthermore. kn-abstract=気管支喘息に対する温泉療法の効果が，これまでどのような評価方法により判定されてきているのかについて，若干の文献的考察を加えた。効果に対する評価方法は，臨床的評価と作用機序と関連した評価方法とに分けて考えることができる。臨床的評価方法としては，自，他覚症状の改善，同時に使用された薬剤の減量の程度，あるいは，肺機能検査の各パラメーターの変動の比較などの方法により行なわれている。一方作用機序と関連した評価では，喘息の発症機序とある程度関連した温泉療法の作用を中心に検討が加えられている。例えば，喘息の発症機序として重要な位置を占める免疫アレルギー反応，自立神経系，内分泌系などと関連した指標を用いて，その変動を観察することによって，効果を明らかにしようとする試みがなされている。これらの検討は極めて意義深いが，なお今後IgE系反応や気道の過敏性との関連 などについての追求が必要であるように考えられる。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 en-keyword=温泉療法 (spa therapy) kn-keyword=温泉療法 (spa therapy) en-keyword=気管支喘息 (bronchial asthrna) kn-keyword=気管支喘息 (bronchial asthrna) en-keyword=免疫アレルギー反応 (immuno-allergic reaction) kn-keyword=免疫アレルギー反応 (immuno-allergic reaction) en-keyword=自律神経系 (autonomic nerve) kn-keyword=自律神経系 (autonomic nerve) en-keyword=内分泌系 (endocrine) kn-keyword=内分泌系 (endocrine) END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=41 end-page=65 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On climatology in Misasa spa (nineth report) kn-title=三朝温泉地の気候について（第9報） en-subtitle= kn-subtitle= en-abstract=Climatological data of the last 12 months (1985.4.1- 1986.3.31) obtained by the climate-autorecording system at the Misasa Medical Branch in Misasa spa, Tottori-Ken, Japan, are presented. kn-abstract=われわれは1956年以降，三朝温泉地の気候要素について観測を行なってきているが，今回は第9報として，ひきつづき1985年4月1日から1986年3月末日までの1カ年の気象観測の資料を報告することとした。なお1985年4月1日以降は自動記録装置が備えられたので，今回の資料はすべてこの自動記録装置によるものである。 en-copyright= kn-copyright= en-aut-name=MatsubaraFumie en-aut-sei=Matsubara en-aut-mei=Fumie kn-aut-name=松原扶美恵 kn-aut-sei=松原 kn-aut-mei=扶美恵 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=2 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=3 ORCID= en-aut-name=MorinagaHiroshi en-aut-sei=Morinaga en-aut-mei=Hiroshi kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=表紙・目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=71 end-page=72 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=看護部だより en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=73 end-page=74 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=事務部だより en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=75 end-page=85 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Publications and lectures in 1986 kn-title=業績集 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=投稿規程 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=裏表紙・英文目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=69 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=198708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=第14回喘息児童の夏期教室へ参加して en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高田信江 kn-aut-sei=高田 kn-aut-mei=信江 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院看護部 END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=105 end-page=129 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On climatology in Misasa spa (tenth report) kn-title=三朝温泉地の気候について（第10報） en-subtitle= kn-subtitle= en-abstract=Climatological data of the last 12 months (1986.4.1-1987.3.31) obtained by the climate autorecording system at the Misasa Medical Branch in Misasa spa, Tottori-Ken, Japan, are presented. kn-abstract=われわれは1956年以降三朝温泉地の気候要素について観測を行ってきているが，今回は第10報として，ひきつづき1986年4月1日から1987年3月末日までの1力年の気象観測の資料を報告することとした。なお1985年4月1日以降は自動記録装置が備えられたので，今回の資料はすべてこの自動記録装置によるものである。 en-copyright= kn-copyright= en-aut-name=MatsubaraFumie en-aut-sei=Matsubara en-aut-mei=Fumie kn-aut-name=松原扶美恵 kn-aut-sei=松原 kn-aut-mei=扶美恵 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=2 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=130 end-page=143 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Publications and lectures in 1987 kn-title=1987年（1月～12月）業績集 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=投稿規定 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=裏表紙・英文目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=表紙・目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=102 end-page=104 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study and trailning in nursing division kn-title=看護部活動報告 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Nursing section en-aut-sei=Nursing section en-aut-mei= kn-aut-name=三朝分院看護部 kn-aut-sei=三朝分院看護部 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=1 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spe therapy for chronic respiratory disease-in subjects admitted in 1987. kn-title=慢性呼吸器疾患の温泉療法 ―1987年度入院症例を対象に― en-subtitle= kn-subtitle= en-abstract=Backgrounds, immunoallergological characteristics and clinical effects of apa therapy were examined in patients with chronic respiratory diseases admitted at Misasa Branch Hospital in 1987. 1. Fifty five patients with chronic respiratory diseases comprised 37 patients with bronchial asthma, 3 with diffuse panbronchiolitis, 3 with chronic cough, 2 with allergic granulomatous angitis, 2 with chronic bronchitis, 2 with hypersensitivity pneumonitis, each 1 with bronchiectasia, pulmonary emphysema and lung tuberculosis. 2. Thirty six patients (69.2%) out of the 52 cases had spa therapy. 3. Out of 22 patients coming from Tottori prefecture, 11 cases (42.3%) received spa therapy. On the other hand, spa therapy was carried out for 25 cases (96.2%) out of the 26 cases coming from the other prefectures (long distant areas). 4. Spa therapy was effective in 25 cases (83.3%) out of the 30 patients with bronchial asthma. Spa therapy was also effective for patients with diffuse panbronchiolitis, allergic granulomatous angitis and bronchiectasia. kn-abstract=1987年1月より12月までの1年間に当院へ入院した慢性呼吸器疾患患者52例を対象に，その背景因子，免疫アレルギー学的要素および温泉療法の臨床効果について検討を加えた。1．対象52例のうちわけは，気管支喘息37例，瀰漫性汎細気管支炎3例，慢性咳嗽3例，アレルギー性肉芽腫性血管炎2例，慢性気管支炎2例，過敏性肺臓炎2例，気管支拡張症，肺気腫，広汎性肺結核症各1例であった。2．これら52症例のうち，温泉療法を受けた症例は36例（69.2％）であった。3．対象症例の地域分布と温泉療法を受けた症例との関係では，鳥取県内の入院症例（26例）で温泉療法を受けた症例は11例（42.3％）であり，県外（遠隔地）からの入院症例（26例）で温泉療法を受けた症例は25例（96.2％）であった。4．温泉療法の臨床効果では，気管支喘息では30例中25例（83.3％）で有効であり，その他1瀰漫性汎細気管支炎，アレルギー性肉芽腫性血管炎，気管支拡張症などで有効であった。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部三朝分院内科 en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=瀰漫性汎細気管支炎 (Diffuse panbronchiolitis) kn-keyword=瀰漫性汎細気管支炎 (Diffuse panbronchiolitis) en-keyword=気管支炎 kn-keyword=気管支炎 en-keyword=気管支肺胞洗浄法 (Bronchoalveolar lavage) kn-keyword=気管支肺胞洗浄法 (Bronchoalveolar lavage) en-keyword=温泉療法 (Spa therapy) kn-keyword=温泉療法 (Spa therapy) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=8 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Maternal swimming at Misasa Hospital Of Okayama University Medical School First report. Recognition of the pregnant women to maternity swimming kn-title=岡山大学医学部附属病院三朝分院における妊婦水泳　第一報　妊婦水泳に関する妊婦の認識について en-subtitle= kn-subtitle= en-abstract=The sports have been contraindication for pregnant women till resent years. Since Dr. Murooka reported the safety and the effectiveness of maternity swimming in 1978. maternity swimming have been taken up and fasionarised by mass media. And then maternity swimming becomes popular in our all over the country. Now we made inquiries about maternity swimming to 25 pregnant women in our outpatients clinic. (Results) 1. Eightyfour percent of them were interested in maternity swimming. 2. Eightyeight percent of them wanted to swim. 3. Most of them had little knowledge about tocological effectiveness of maternity swimming. (Conclusion) It is nessesary that the enlightenment and the active management of maternity swimming by obstetricians. kn-abstract=妊婦のスポーツに対する考え方は近年まで比較的消極的であったが，最近マスコミに取り上げられるようになり，妊婦水泳・エアロビクスダンス等は全国的にもかなり普及していると思われる。今回外来通院患者を対象に妊婦水泳に関するアンケート調査を行った結果，大多数のものが関心を持ち，また実施希望を持っていることが判明したのでその概要を報告する。 en-copyright= kn-copyright= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=1 ORCID= en-aut-name=SugaKiyohiro en-aut-sei=Suga en-aut-mei=Kiyohiro kn-aut-name=須賀清博 kn-aut-sei=須賀 kn-aut-mei=清博 aut-affil-num=2 ORCID= en-aut-name=SakataJunko en-aut-sei=Sakata en-aut-mei=Junko kn-aut-name=坂田旬子 kn-aut-sei=坂田 kn-aut-mei=旬子 aut-affil-num=3 ORCID= en-aut-name=YosidaSachie en-aut-sei=Yosida en-aut-mei=Sachie kn-aut-name=吉田佐知江 kn-aut-sei=吉田 kn-aut-mei=佐知江 aut-affil-num=4 ORCID= en-aut-name=MifuneMasaaki en-aut-sei=Mifune en-aut-mei=Masaaki kn-aut-name=御船政明 kn-aut-sei=御船 kn-aut-mei=政明 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=妊婦水泳 (Maternity swimming) kn-keyword=妊婦水泳 (Maternity swimming) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=12 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Characteristic pancreatographic findings in chronic pancreatitis and their diagnostic value. …Studies on post mortem pancreas… kn-title=慢性膵炎における膵管X線像の診断学的価値 ―屍体膵を用いての検討― en-subtitle= kn-subtitle= en-abstract=Postmortem pancreas tissue was prepared within 6 hours of death for the comparative study of pancreatographic findings and histological findings to define characteristic pancreatographic findings of chronic pancreatitis and determine their diagnostic value. Pancreas tissue was obtained from 25 patients with chronic pancreatitis and 125 with a normal pancreas. Among various pancreatographic findings, irregular dilatation and irregular arrangement of the branches of the pancreatic duct, and also irregular dilatation, rigidity with irregular margin and stenosis with irregular margin of the main pancreatic duct showed the highest sensitivity. specificity, positive predictive value and negative predictive value and conseqently had the highest diagnostic valus. However, the sensitivity was not high enough, indicating that the above pancreatographic findings could be absent at the site of positive histological findings in mild chronic pancreatitis. kn-abstract=慢性膵炎25例および対照として正常例125例計150例の新鮮剖検膵を用いて膵管造影を行い，X線所見と同部位の組織所見とを厳密に対比させ，慢性膵炎における各X線所見の診断学的価値を検討した。その結果，主膵管像では不整拡張像，硬化＋辺縁不整像，狭窄＋辺縁不整像が，分枝像では不整拡張像および不整配列像が，positive predictive value（PPV），specificity（Sf），negative predictive value（NVP）ともに77.1～100％　の高率を示した。しかしsensitivity（St）は，2.1～18.1％　と低率であった。したがって，これらの所見は慢性膵炎を診断する上で組織予見性および特異性に優れた診断的価値のあるX線所見と言える。しかし一方では軽症の慢性膵炎の検出能はあまりよくないという限界が膵管造影法にはある。 en-copyright= kn-copyright= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=1 ORCID= en-aut-name=MatumotoShuuji en-aut-sei=Matumoto en-aut-mei=Shuuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=2 ORCID= en-aut-name=OchiKouji en-aut-sei=Ochi en-aut-mei=Kouji kn-aut-name=越知浩二 kn-aut-sei=越知 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=4 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=慢性膵炎 (chronic pancreatitis) kn-keyword=慢性膵炎 (chronic pancreatitis) en-keyword=膵管造影像 (pancreatogpaphy) kn-keyword=膵管造影像 (pancreatogpaphy) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=17 end-page=23 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical evaluation of endoscopic ultrasonography (EUS) in the diagnosis of gastric disease. kn-title=胃疾患診断における超音波内視鏡の有用性の検討 en-subtitle= kn-subtitle= en-abstract=We performed EUS in seven cases with gastric cancer, one with gastric malignant lymphoma, two with submucosal tumor of the stomach (SMT), two with tumourous compression by extra-gastric organs and three with others. Except one case with early gastric cancer, the depth of cancerous lnvasion was correct1y diagnosed by EUS. It was posible to detect which layer had SMT in the 5 layer strcture of the gastric wall by EUS and it was helpful in determination of histological origin of SMT. Furthermore EUS was able to make the differential diagnosis between SMT and tumourous compression by extra gastric organ. Our result showed that EUS was a useful procedure in the diagnosis of gastric diseases. kn-abstract=ラジアルセクタ式超音波内視鏡（EUS）を，15例の胃疾患患者に用い，その有用性を検討した。胃癌の深達度診断は併存潰瘍を有するm癌の1例をsm癌とした以外は，いずれも正診であり，胃癌の深達度診断にEUSが有用であることが示唆された。その他，胃粘膜下腫瘍の占拠部位や発育様式の診断や壁外性圧排との鑑別など胃疾患の診断にEUSの有用性が示唆され，文献的考察を加えて報告した。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越知浩二 kn-aut-sei=越知 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=4 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=5 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=超音波内視鏡 (Endoscopic ultrasonography) kn-keyword=超音波内視鏡 (Endoscopic ultrasonography) en-keyword=胃癌 (Gastric cancer) kn-keyword=胃癌 (Gastric cancer) en-keyword=胃粘膜下腫瘍 (Submucosal tumor of the stomach) kn-keyword=胃粘膜下腫瘍 (Submucosal tumor of the stomach) en-keyword=癌深達度診断 (Diagnosis of the depth of cancerous invasion) kn-keyword=癌深達度診断 (Diagnosis of the depth of cancerous invasion) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=24 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Early diagnosis of pancreatic cancertrial of a mass screening test for detecting early pancreatic cancer kn-title=膵癌の早期診断法の検討 ―膵集検の試み― en-subtitle= kn-subtitle= en-abstract=There is no other way of curing pancreatic cancer than early diagnosis and resection. However, an effective protocol has not been established for detecting early pancreatic cancer among asymptomatic populations by means　of a mass screening test. Therefore, a prospective study was attempted on 776 patients who came to Medical Clinic of Misasa Branch Hospital, Okayama University Medical School mostly for a routine annual check-up. The following tentative protocol was proposed, based on the retrospective analyses of our 13 patients with early pancreatic cancer: (1) a first step test includes serum amylase, elastase Ⅰ, alkaline phosphatase, r-GTP, carcinoembryonic antigen, fasting blood sugar and routine abdominal ultrasonography (US); (2) a second step test includes thorough abdominal US with various kinds of probes and patients' positioning which was performed on individuals with abnormal findings on the first step test, (3) a third step test includes ERCP which was performed on individuals with abnormal or questionable findings on the second step test. Further detail examinations were performed when ERCP was abnormal or questionable. Consequently 357 patients (46% of the total 776 patients) underwent thorough US and 45 patients (5.8%) underwent ERCP. ERCP findings included pancreatic cancer in two patients, suspect of pancreatic cancer in three, advanced chronic pancreatitis in two, equivocal as for chronic pancreatitis (according to the Cambridge classification) in nine, and normal in 29. Final diagnosis was early pancreatic cancer in one patient, advanced pancreatic cancer in two, and calcified chronic pancreatitis in two; detection rate of pancreatic cancer (0.39%) in this series was slightly higher than that usually reported with a mass screening test for stomach cancer. From a cost-benefit point of view, however, examinations for the pancreas cost 2.6 times as much as those for the stomach. Further studies are needed (1) to refine the protocol, (2) to improve cost-benefit efficiency, (3) and also to confirm by follow-up that no cases of pancreatic cancer have passed through the test undetected. kn-abstract=膵癌を治癒に導くためには早期診断，早期切除以外に方法はない。そこで，無症状者のなかから早期膵癌を発見するためのスクリーニング法を検討するためProspective studyを実施した。人間ドック目的の来院患者を主とする三朝分院外来患者776名を対象とし，一次スクリーニング検査として，血清アミラーゼ，エラスターゼⅠ，CA19－9，アルカリフォスファターゼ，γ-GTP，血糖値の測定および腹部超音波検査を施行し，異常者に対して二次スクリーニングとして腹部超音波検査の再精査およびERCPを施行した。その結果，早期膵癌1例および進行膵癌2例を検出し，膵癌発見率は0.39％　と満足のいく結果が得られた。しかし一次スクリーニング検査の要精検率は46％　と高値を示したこと，一次スクリーニング検査の費用は胃集検の約3.3倍，二次スクリーニング検査の費用は胃精査の約2.6倍かかることからcost-benifitの面で問題となった。また見逃し症例の有無をモニターするためfollow upも今後の問題として残った。 en-copyright= kn-copyright= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越知浩二 kn-aut-sei=越知 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=3 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=膵集検 (Mass screening) kn-keyword=膵集検 (Mass screening) en-keyword=早期膵癌 (Early pancreatic cancer) kn-keyword=早期膵癌 (Early pancreatic cancer) en-keyword=膵癌の早期診断 (Early diagnosis of pancreatic cancer) kn-keyword=膵癌の早期診断 (Early diagnosis of pancreatic cancer) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=31 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息および慢性気管支炎患者における抗ヒトIgEによる好塩基球からのヒスタミン遊離 kn-title=Basophil histamine release by anti-IgE in Subjects of chronic bronchitis and bronchial asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息50例，慢性気管支炎8例を対象に，抗ヒトIgE添加時の好塩基球からのヒスタミン遊離を全血法により行ない，その臨床的評価について検討を加えた。抗ヒトIgE海底時のMax　％　histamine releaseの平均は，健康人24.7±14.2％，慢性気管支炎27.7±22.1％，気管支喘息28.4±17.0％であり，3者間に有意の差はみられなかった。すなわち，抗ヒトIgE添加により健康人や慢性気管支炎患者の好塩基球からも有意のヒスタミン遊離が見られた。気管支喘息のなかでは，内因性喘息症例においてヒスタミン遊離（14.1±7.2％）の低い傾向が見られた。Dose-response curveの検討では，健康人，慢性気管支炎症例では全例E（2）からE（1）へかけてのnegative slopeを示した。気管支喘息症例では，血清IgE値500IU/ml以下の症例ではnegative slopeを示す症例が多く，一方501IU/ml以上の症例ではpositive slopeを示す症例がより多く見られた。 kn-abstract=Histamine release from basophils induced by anti-IgE was studied in 8 patients with chronic bronchitis and 50 patients with bronchial asthma by analyzing doseresponse curves. As the result, there were no significant differences in maximum percent histamine release from basophils among three groups of healthy subjects (24.7± 14.2%), patients with chronic bronchitis (27.7±22.1%) and those with bronchial asthma (28.4±17.0%). In the patients with bronchial asthma, the maximum percent histamine release was higher in accordance with higher serum IgE levels, and low maximum percent release was observed in patients with intrinsic asthma (14.1±7.2%). Study of dose-response curves of anti-IgE-induced histamine release showed that a negative slope from E(2) to E(1) was observed in both healthy subjects and patients with chronic bronchitis. The majority of asthmatics with serum IgE levels of 501IU/ml or over showed a positive slope from E(2) to E(1). en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=4 ORCID= en-aut-name=TsujiMitsuaki en-aut-sei=Tsuji en-aut-mei=Mitsuaki kn-aut-name=辻光朗 kn-aut-sei=辻 kn-aut-mei=光朗 aut-affil-num=5 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=6 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=Basophil response (好塩基球の反応性) kn-keyword=Basophil response (好塩基球の反応性) en-keyword=Anti-lgE (抗ヒトIgE) kn-keyword=Anti-lgE (抗ヒトIgE) en-keyword=Histamine release (ヒスタミン遊離) kn-keyword=Histamine release (ヒスタミン遊離) en-keyword=chronic bronchitis (慢性気管支炎) kn-keyword=chronic bronchitis (慢性気管支炎) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=37 end-page=41 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Separation of paripheral leukocytes by counterflow centrifugation elutriation kn-title=JE－6B　rotor（Beckman）による末梢血白血球分離の検討 en-subtitle= kn-subtitle= en-abstract=Separation of peripheral leukocytes was carried out in 5 healthy subjects by counterflow centrifugation elutriation with JE-6B rotor. 1. Number of lymphocytes was predominant at low flow rate (4.5ml/min) of counterflow centrifugation elutriation. 2. As flow rate was increased (9-10ml/min), the purity and number of basophils, and histamine content in the fraction were gradually increased. 3. The purity and number of neutrophils were gradually increased, and the purity was reached the peak at 13ml/min. 4. The purity and number of eosinophils were gradually increased at the late stage of the centrifugation elutriation. The results obtained here might suggest that cell separation by counterflow centrifugation elutriation is more useful for experiments, especially allergy testing, in vitro. kn-abstract=JE－6B　rotor（Beckman）を用いてcounterflow　centrifugation　elutriationによる末梢血白血球の分離を試み，若干の検討を加えた。1．flow　rateが低い場合はリンパ球が大部分を占めたが，flow　rateの増加とともに頻度は減少した。2．　flow　rateの増加とともに，好塩基球の頻度が増加し，9－10ml／minでは頻度のみでなく細胞数の増加も認められた。各fractionにおけるヒスタミン含有量も同様の傾向が認められた。3．好中球のpeakはflow　rate　13ml／minであり以後減少を示した。4．最終段階で好酸球が増加傾向を示しChamber内で最も高値を示した。以上の結果よりcounterflow　centrifugation　elutriationによる末梢血白血球細胞分離は，in　vitroにおける実験に有用な手段である可能性が示唆された。 en-copyright= kn-copyright= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=1 ORCID= en-aut-name=MatsubaraFumie en-aut-sei=Matsubara en-aut-mei=Fumie kn-aut-name=松原扶美恵 kn-aut-sei=松原 kn-aut-mei=扶美恵 aut-affil-num=2 ORCID= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=3 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部三朝分院内科 en-keyword=逆流負荷遠心法 (Counterflow centrifugation elutriation) kn-keyword=逆流負荷遠心法 (Counterflow centrifugation elutriation) en-keyword=JE－6Bローター (JE-6B rotor) kn-keyword=JE－6Bローター (JE-6B rotor) en-keyword=細胞分離 (Cell separation) kn-keyword=細胞分離 (Cell separation) en-keyword=好塩基球 (Basophils) kn-keyword=好塩基球 (Basophils) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=42 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Atopic asthma in patients of middle or advanced age kn-title=中高年令者のアトピー型喘息について en-subtitle= kn-subtitle= en-abstract=In order to elucidate the characteristics of atopic asthma in patients of middle or advanced age (over 41 years old), 88 atopic asthmatic patients were divided into 4 groups according to their ages, 0～20, 21～40, 41～60 and over 61 years old, and age, sex, age of onset, past history, family history, number of peripheral eosinophils, serum IgE and skin test were compared among these groups. The results were as follows: Atopic ashmatic patients of middle or advanced age were 1) less frequent in all asthmatic patients of same age group, 2) more frequent in males than in females, 3) higher in averaged age of onset, 4) more frequent in cases without other allergic past histories, 5) less frequently positive to house dust and more frequently positive to Candida and Aspergillus in skin test, 6) not different in family history, number of peripheral eosinophils and serum IgE compared to other groups. kn-abstract=中高年令（41才以上）のアトピー型喘息患者の特徴を明らかにするために，アトピー型喘息患者88例を0～20才，21～40才，41～60才，61才以上の各年令別に分け，年令，性別，発症年令，既往歴，家族歴，末梢血好酸球，血清IgE値，皮内反応の各項目について検討を加えた。結果は，中高年のアトピー型喘息患者は1）その年代の全喘息患者に占める割合は低く，2）男性が多く，3）平均発症年令は高く，4）その他のアレルギー性疾患の既往歴を持たない症例が比較的多く，5）皮内反応では，ハウスダスト陽性率が比較的低く，カンジダ，アスペルギルスの陽性率は比較的高い傾向にあった。6）家族歴，末梢血好酸球，血清IgE値では，明らかな傾向は認められなかった。 en-copyright= kn-copyright= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部三朝分院内科 en-keyword=アトピー (Atopy) kn-keyword=アトピー (Atopy) en-keyword=中高年令者 (patients of middle or advanced age) kn-keyword=中高年令者 (patients of middle or advanced age) en-keyword=喘息 (asthma) kn-keyword=喘息 (asthma) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=47 end-page=53 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on steroid-dependent intractable asthma kn-title=ステロイド依存性重症難治性喘息の臨床的検討 －免疫アレルギー学的検討－ en-subtitle= kn-subtitle= en-abstract=Clinical studies on steroid-dependent intractable asthma were carried out in 56 patients relating to immuno-allergic aspects. 1. In most half of the patients with steroid-dependent intractable asthma, age at onset of the disease was 41 years old or over (so-called "Late Onset Asthma"). 2. The frequency of positive skin reaction for house dust was relatively low. whereas that for Candida was relatively high. 3. The serum IgE concentrations of these patients were in general low. Many patients showed low serum IgE concentrations of less than 300IU/ml. The concentrations of specific IgE antibodies for house dust and Candida albicans were also low. 4. The concentrations of specific IgG antibodies for Candida albicans were high compared to those for house dust. 5. Basophil histamine release induced by house dust and Candida albicans was not so remarkable in majoriy of these patients, while anti-IgE-induced histamine release from basophils ranged widely. 6. In these patients, small airway obstruction was suggested in ventilatory function test. 7. In clinical classificatin of asthma, type Ⅰa; bronchospasm type was a few, while type Ⅰb; hypersecretion and type Ⅱ; bronchiolor obstruction type were dominant in the cases studied here. kn-abstract=ステロイド依存性重症難治性喘息56例について免疫アレルギー学的検討を行った。その結果41才以降発症のLate　Onset　Asthmaが約半数を占め，血清IgE値が比較的低値であり，ハウスダストに対しての皮内反応，特異的IgE抗体価，ヒスタミン遊離はいずれも全般的に低く，カンジダに対しての皮内反応，特異的IgG抗体価はむしろ比較的高く，肺機能では末梢気道閉塞の傾向が窺われ，臨床分類では，気管支攣縮＋過分泌型，および細気管支閉塞型が多数を占める等の特徴を有することが明らかにされた。 en-copyright= kn-copyright= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=1 ORCID= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= en-aut-name=TsujiMituaki en-aut-sei=Tsuji en-aut-mei=Mituaki kn-aut-name=辻光明 kn-aut-sei=辻 kn-aut-mei=光明 aut-affil-num=5 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=6 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学第二内科 affil-num=6 en-affil= kn-affil=岡山大学第二内科 affil-num=7 en-affil= kn-affil=岡山大学第二内科 en-keyword=ステロイド依存性喘息 (Steroid-dependent asthma) kn-keyword=ステロイド依存性喘息 (Steroid-dependent asthma) en-keyword=血清IgE (Serum-IgE) kn-keyword=血清IgE (Serum-IgE) en-keyword=特異的IgE (Specific lgE) kn-keyword=特異的IgE (Specific lgE) en-keyword=特異的IgG (Specific IgG) kn-keyword=特異的IgG (Specific IgG) en-keyword=中高年発症型喘息 (Late onset asthma) kn-keyword=中高年発症型喘息 (Late onset asthma) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=54 end-page=61 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Changing conception of indication for peripheral arterial reconstruction surgery. kn-title=末梢動脈の慢性閉塞性疾患の治療 －変りつつある適応－ en-subtitle= kn-subtitle= en-abstract=Peripheral arterial reconstruction surgery for chronic occlusive diseases has not always produced satisfactory results according to long-term (5-10 years) follow-up studies. Furthermore, application of synthetic vascular prostheses of small caliber for peripheral reconstruction is quite restricted to certain circumstances, because of the complications derived from long-term implantation such as thickening and degeneration of the inner capsule and deterioration of the grafts used. On the other hand, experimental studies on ischemic limbs revealed a significant increase of tissue perfusion in 3, 6 and 12 months following ischemia was induced (p<0.001) compared with the acute ischemic stage in freely moving dogs by means of medical mass spectrometry. In addition, subcutaneous tissue perfusion was found increased by about 30 % with CO(2) bathings in combination with Radon inhalation of high concentration (over 5000 Bq/l), which was accompanied by an elevation of subcutaneous pO(2). Therefore, medical treatments such as walking exercise and bathings with CO(2) and Radon based on the natural history of chronic peripheral arterial occlusive diseases, particularly intermittent claudication, appear feasible. kn-abstract=末梢動脈の慢性閉塞性疾患に対する直達血行再建術の長期の予後は必ずしも満足できるものではない。合成代用血管は，長期の植え込みにより内被の肥厚，退行性変性，および材質の変性の様な合併症により，特に小口径の合成代用血管の適応は極めて限られたものになっている。一方，医用質量分析装置を用いた虚血肢の実験的研究によると，自由に運動させた犬の虚血肢では，急性期に比較すると3カ月以後その組織循環は有意に増加することが明らかとなった。また，家兎を用いた実験的研究によると，炭酸泉浴に高濃度のラドン吸入を合併すると皮下組織の組織循環が約30％増加して，同時に皮下の酸素分圧が上昇することを確かめた。従って，切迫壊死の症例をのぞいて，末梢動脈の慢性閉塞性疾患々肢，特に間欠性跛行に対しては，自 然予後を考慮して歩行負荷，および炭酸泉，ラドン泉の温泉療法を用いた保存的療法が長期の予後上効果的である。 en-copyright= kn-copyright= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=1 ORCID= en-aut-name=NakaoToshihiko en-aut-sei=Nakao en-aut-mei=Toshihiko kn-aut-name=中尾俊彦 kn-aut-sei=中尾 kn-aut-mei=俊彦 aut-affil-num=2 ORCID= en-aut-name=SunakawaMitsuru en-aut-sei=Sunakawa en-aut-mei=Mitsuru kn-aut-name=砂川満 kn-aut-sei=砂川 kn-aut-mei=満 aut-affil-num=3 ORCID= en-aut-name=YagiNobuko en-aut-sei=Yagi en-aut-mei=Nobuko kn-aut-name=矢木信子 kn-aut-sei=矢木 kn-aut-mei=信子 aut-affil-num=4 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=5 en-affil= kn-affil=花王株式会社栃木研究所 en-keyword=虚血肢 (lshemic limb) kn-keyword=虚血肢 (lshemic limb) en-keyword=末梢血行再建術 (Peripheral arterial reconstruction) kn-keyword=末梢血行再建術 (Peripheral arterial reconstruction) en-keyword=組織循環 (Tissue perfusion) kn-keyword=組織循環 (Tissue perfusion) en-keyword=歩行運動 (Walking exercise) kn-keyword=歩行運動 (Walking exercise) en-keyword=温泉療法 (Balneotherapy) kn-keyword=温泉療法 (Balneotherapy) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=62 end-page=67 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Allergic reactions for severe intractable asthma and spa therapy kn-title=気管支喘息における重症難治化反応と温泉療法 en-subtitle= kn-subtitle= en-abstract=Reactions for severe intractable asthma and actions of spa therapy on the reactions were discussed. Reactions participatng in onset mechanism of bronchial asthma were divided into three major groups. The first group comprises IgE-mast cell (eliciting phase), histamine (leukotrienes) (reactive phase; humoral phase), and lymphocytes-basophils-eosinophils (reactive phase; cellular phase). The second group comprises IgG-neutrophils, leukotrienes, and neutrophils-lymphocytes-macrophages. The third group is induced by non-IgE reactions, followed by PAF and eosinophils (with blood eosinophilia), and by leukotrienes and lymphocytes (without blood eosinophilia). If these reactions are really present and participate in onset mechanism of bronchial asthma, the first group could be observed in atopic asthma, the second one in late onset asthma, and the third one in so-called intrinsic asthma with blood eosinophilia and in late onset asthma without blood eosinophilia. Spa therapy has clearing actions of airway and improves function of adrenal glands in severe intractable asthma. kn-abstract=予後良好と言われる気管支喘息が，どのような反応系により重症難治化傾向を取るのか，そして温泉療法がどのように作用するのかについて，若干の検討を加えた。まず関与する反応系は，その惹起相，反応相（液性因子相，細胞性因子相）の組合せにより，代表的な3つの反応系に分類することができる。1）IgE－肥満細胞（惹起相）；ヒスタミン（ロイコトリエン）（液性因子相）；リンパ球，好塩基球，好酸球（細胞性因子相），2）IgG－好中球；ロイコトリエン；好中球，リンパ球，マクロファージ，3）非IgE系反応；PAF；好酸球，3'）非IgE系反応；ロイコトリエン；リンパ球。このような機序がもし存在するとすれば，1）の反応系の関与する喘息はアトピー型喘息，2）は中高年発症型喘息，3）は所謂内因性喘息，3'）は中高年発症型喘息として把握される可能性が強い。温泉療法は，気道清浄化作用および副腎皮質機能改善作用により，これらの反応系の発現を抑制する。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=難治性喘息 (lntractable asthma)　 kn-keyword=難治性喘息 (lntractable asthma)　 en-keyword=アレルギー反応 (Allergic reaction) kn-keyword=アレルギー反応 (Allergic reaction) en-keyword=温泉療法 (Spa therapy) kn-keyword=温泉療法 (Spa therapy) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=68 end-page=82 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Etiology and pathogenesis of chronic pancreatitis kn-title=慢性膵炎の成因，病態と発生機序 en-subtitle= kn-subtitle= en-abstract=Main etiologies of chronic pancreatitis (CP)include "alcoholic" (60%), "idiopathic" (27%)and "biliary" (8%). Clinico-pathological features comprise intractable abdominal pain, maldigestion secodary to exocrine pancreatic insufficiency and diabetes secondary to endocrine pancreatic insufficiency. Death is not infrequent during follow-up. Pathogenesis and evolution of alcoholic CP were discussed in connection with "Big Duct Theory", "Toxic-Metabolic Theory", and "Protein Plug Theory". Diet and congenital predisposition as well as alcoholic comsumption play important roles in various combinations in the pathogenesis and evolution of CP. Important initial lesins of alcoholic CP are probably : (1) pancreatic ductular Obstruction due to proetin plug formation resulting from increased protein and mucoprotein concentration in pancreatic juice ; (2) damage and sloughing of ductular epithelia caused by protein plugs or by a direct toxic effect of ethanol secreted into pancreatic juice, and subsequent ductular stenosis and peri-ductular fibrosis. Parenchymal destruction with interstitial fibrosis is induced upstream to the ductular lesions. These, structural abnormalities and multiple biochemical abnormalities of pancreatic juice further lead to self-perpetuating evolution. Anti-acinar-cell antibody, anti-duet-cell antibody and immune complex in serum are most probably mere epiphenomena and not the causes of CP. kn-abstract=慢性膵炎の成因の主たるものは，アルコール性，特発性，胆石性である。病態面では，社会的・家庭的にもっとも責任が重い壮年期に頑固な疼痛，消化吸収障害，二次性糖尿病のために生活の質が低下することが問題になる。経過中に併発してくる膵およびそのほかの臓器の癌，および糖尿病の合併症による死亡も少なくない。アルコール性慢性膵炎の初期病変の発生機序としては，①膵過分泌の結果として細膵管内に形成される蛋白栓による膵液流出障害と，②蛋白栓あるいはアルコールの直接障害作用による細膵管上皮の損傷，およびその結果生じる膵管狭窄による膵液流出障害が注目されている。膵液流出障害はその上流域に実質細胞の破壊と間質の線維化をおこす。膵液には多くの生化学的異常が認められ，いったん発生した膵管の構造異常とあいまって慢性膵炎進展の原因となる。素因および栄養のアンバランスは発症，進展の促進因子となる。発症を予防し，進展を阻止する手段を開発するためには素因および飲酒・食事を含む環境因子の解析が今後の重要な課題である。 en-copyright= kn-copyright= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=1 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=4 ORCID= en-aut-name=SenouToshinobu en-aut-sei=Senou en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=5 ORCID= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=6 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 en-keyword=慢性膵炎 (Chronic pancreatitis) kn-keyword=慢性膵炎 (Chronic pancreatitis) en-keyword=成因 (Etiology) kn-keyword=成因 (Etiology) en-keyword=発生機序 (Pathogenesis) kn-keyword=発生機序 (Pathogenesis) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=83 end-page=92 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=トランスフェリンを介する鉄の細胞内取り込み機序 ―特に肝細胞への取り込みにおける内皮細胞の関与について― kn-title=Transferrin-Mediated Cellular Iron Uptake -Special Implication of Endothelium in Hepatic Iron Uptake- en-subtitle= kn-subtitle= en-abstract=トランスフェリン（Tf）は鉄代謝において重要な役割を担っている。鉄を必要とする細胞の表面には，Tfの特異的受容体が存在し，Ffは受容体との結合に引き続いて，coated　pitsとcoated　vesiclesを介して細胞内に取り込まれる（internalization）。Vesicle内での急速なpHの低下にともない，鉄はTfから分離し，細胞内で分画される。一方，鉄を失ったTf（アポTf）は受容体と結合したまま細胞表面にもどり，中性のpHのもとで受容体から解離する。最近の細胞・分子生物学の進歩，遺伝子クローニング，ならびにモノクローナル抗体の開発により，分子レベルで鉄代謝経路が解明されつつある。今回，これまでの主要な知見をまとめ，特に，最近筆者らの研究により明らかとなった，肝の鉄代謝における内皮細胞の役割について考察した。 kn-abstract=Transferrin (Tf) is thought to play a pivotal role in iron metabolism of various kinds of cells. Tf has specific receptors on the surface of the cells that require iron. Tf-receptor binding is followed by internalization through a system of coated pits and vesicles. The rapid decline of pH of these vesicles leads to the release and sequestration of iron by the cell. Apotransferrin-receptor complex returns to the cell surface, where under neutral pH conditions, apotransferrin is dissociated from the receptor. Recent advances in cellular and molecular biology, gene cloning and monoclonal antibody technique have elucidated many features of these processes at a molecular level. These advances are briefly reviewed, and particularly, our own observations concerning endothelial mediation of uptake of Tf by hepatocytes are discussed. en-copyright= kn-copyright= en-aut-name=IrieSeiji en-aut-sei=Irie en-aut-mei=Seiji kn-aut-name=入江誠治 kn-aut-sei=入江 kn-aut-mei=誠治 aut-affil-num=1 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=MehdiTavassoli en-aut-sei=Mehdi en-aut-mei=Tavassoli kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=7 en-affil= kn-affil=ミシシッピ州立大学医学部 en-keyword=Iron uptake (鉄の細胞内取り込み) kn-keyword=Iron uptake (鉄の細胞内取り込み) en-keyword=Transferrin (トランスフェリン) kn-keyword=Transferrin (トランスフェリン) en-keyword=Receptor-Mediated Endocytosis kn-keyword=Receptor-Mediated Endocytosis en-keyword=Desialation (脱シアル化) kn-keyword=Desialation (脱シアル化) en-keyword=Endothelium (内皮細胞) kn-keyword=Endothelium (内皮細胞) END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=93 end-page=96 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Changes in X-ray examinations. kn-title=放射線室における患者，検査の推移について ―患者数・件数・撮影枚数― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=1 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 END start-ver=1.4 cd-journal=joma no-vol=59 cd-vols= no-issue= article-no= start-page=97 end-page=101 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=198808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Application of personal computer in X-ray room business. kn-title=放射線業務におけるパソコン活用 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=1 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院放射線室 END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=47 end-page=53 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=IgE-mediated reaction in non-atopic asthma kn-title=非アトピー型喘息におけるIgE系反応 en-subtitle= kn-subtitle= en-abstract=IgE-mediated reaction was studied in non-atopic asthma in comparison with atopic asthma. 1. In early onset asthma patients (younger than 20 years at onset of the disease), the mean serum IgE level was 947±656IU／mℓ in non-intractable asthma cases and 214±102IU／mℓ in intractable cases. A positive RAST score to house dust was observed in 12 cases (80%) out of 15 non-intractable cases, and 6 (50%)out of 15 intractable cases. 2. In late onset asthma patients (older than 40 years at onset), the mean serum IgE level was 388±324IU／mℓ in non-intractable cases and 253±82IU／mℓ in intractable cases. There were no cases with a positive RAST score to house dust in intractable cases. These results may suggest that there is a correlation between decreased IgE-mediated reaction and a tendency to intractable asthma. 3. There were some differences in IgE mediated reaction among atopic, non-atopic asthma cases and healthy subjects, suggesting that IgE-mediated reaction may partially participate in the onset of non-atopic asthma in a suppressed condition. kn-abstract=気管支喘息の発症にIgE抗体がどの程度関与しているのかを中心に若干の検討を加えた。1．若年発症型喘息（発症；20才以下，現年齢；30才以下）では，非難治例15例の血清IgE値は947±656IU／mℓで，HDのRASTが陽性を示した症例は12例（80％），難治例12例では血清IgE値214±102IU／mℓで，HDのRAST陽性は6例（50.0％）であった。2．一方，中高年発症型喘息（発症；40才以後）では，非難治例15例の血清IgE値は388±324IU／mℓで，HDのRAST陽性は6例（40％）であったが，難治例15例ではIgE値253±82IU／mℓで，HDのRASTは全例陰性であった。これらの結果から，いずれの群においても，IgE系反応が弱い場合に喘息が重症化しやすいことが示された。3．アトピー型，健康人，非アトピー型におけるI1gE系反応（皮内反応，血剤IgE，特異的IgE，ヒスタミン遊離）の陽性率や強度は，それぞれ異なっていたが，非アトピー型においてもIgE系反応が低下ないし抑制された状態で関与している可能性が示唆された。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学三朝分院内科 en-keyword=アトピー型喘息 (Atopic asthma) kn-keyword=アトピー型喘息 (Atopic asthma) en-keyword=非アトピー型喘息 (Non-atopic asthma) kn-keyword=非アトピー型喘息 (Non-atopic asthma) en-keyword=皮内反応 (Skin reaction)　 kn-keyword=皮内反応 (Skin reaction)　 en-keyword=血清IgE (Serum lgE) kn-keyword=血清IgE (Serum lgE) en-keyword=特異的lgE (Specific lgE) kn-keyword=特異的lgE (Specific lgE) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=1 end-page=5 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of long-term daily intake of thermal water on gastric mucosal blood flow kn-title=胃粘膜血流に及ぼす温泉水の効果 －長期連日飲泉の効果－ en-subtitle= kn-subtitle= en-abstract=Effect of long-term oral intake of thermal water on gastric mucosal blood flow was evaluated, using an endoscopic organ reflex spectrophotometry together along with an Olympus XQ-10 forward viewing gastro-fiberscope． Three healthy volunteers and nine patients with gastric diseases in remission (six with healed gastric ulcer and three with chronic gastritis) were put on a 2-week treatment with daily oral intake of Misasa thermal water (38 to 42 ℃, 200mℓ, two times a day between meals). Gastric mucosal blood flow was measured just before and after the treatment period at three spots of the stomach (lesser curvature of the pylorus, antrum and angle) : Life style and drugs were unchanged during the period. Following results were obtained : (1) Pre-and post-treatment gastric mucosal blood flow (IHb) was 95.0±18.0, and 98.2±15.3 at the pylorus, respectively ; 104.8±16.9 and 110.8±12.8 at the antrum, respectively ; 116.1±20.4 and 118.7±18.5 at the angle, respectively. (2) However, Evaluation of each individual case showed that the post-treatment values were　higher than the pretreatment ones in 75 % of patients at the pylorus and in 67 % of patients at the antrum and angle, respectively. (3) Student's paired t-test showed that the post-treatment increase in blood flow was statistically significant (p<0.05) only at the antrum． These results suggest that an improvement in gastric mucosal blood flow, along with an improvement in gastric secretion and motility, is also contributory to the favorable therapeutic results of spa-drink in chronic gastric diseases. Further studies are in progress to reveal (1) the clinical significance of the improvement in gastric mucosial blood flow, such asacceleration of healing and maintenance of remission, and (2) the characteristics of patients who are likely to show favorable response to the treatment． kn-abstract=内視鏡（オリンパス製XQ－10胃ファイバースコープ）と臓器反射スペクトル法を応用して，2週間連日の飲泉が胃粘膜血流におよぼす効果を検討した。健常者3名および胃疾患患者9名（治癒期にある胃潰瘍の患者6名と慢性胃炎の患者3名）を対象とした。当院飲泉場の温泉水による2週間連日の飲泉を行ない，2週間の飲泉の前後において，胃の3箇所（胃幽門部小弯，前庭部小弯，胃角部小弯）で胃粘膜血流を測定した。その結果，胃前庭部小弯では胃粘膜血流の有意の増加を認めた。しかし胃全体としては有意差を検出出来なかった。個々の症例について検討すると、飲泉後で胃の3箇所すべてにおいて血流が増加したケースが頻度多く認められ，飲泉の有効性が示唆された。従来から認められてきた慢性胃腸疾患に対する飲泉の効果には，胃粘膜血流の改善による要因も加わっている可能性が考えられる。 en-copyright= kn-copyright= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=1 ORCID= en-aut-name=SenouToshinobu en-aut-sei=Senou en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=2 ORCID= en-aut-name=MatumotoShuji en-aut-sei=Matumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=IshibashiTadaaki en-aut-sei=Ishibashi en-aut-mei=Tadaaki kn-aut-name=石橋忠明 kn-aut-sei=石橋 kn-aut-mei=忠明 aut-affil-num=4 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=飲泉療法 (Spa-drink therapy) kn-keyword=飲泉療法 (Spa-drink therapy) en-keyword=胃粘膜血流 (Gastric mucosal blood flow) kn-keyword=胃粘膜血流 (Gastric mucosal blood flow) en-keyword=臓器反射スペクトル法 (Organ reflex spectrophotometry) kn-keyword=臓器反射スペクトル法 (Organ reflex spectrophotometry) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=6 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy for chronic respiratory disease- in subjects admitted in 1988. kn-title=慢性呼吸器疾患の温泉療法 ―1988年度入院症例を対象に― en-subtitle= kn-subtitle= en-abstract=Backgrounds, immpnological characteristics and clinical effects of spa therapy were examined in patients with chronic respiratory disease admitted at Misasa Branch Hospital in 1988. 1. Sixty two patients with chronic respiratory disease comprised 49 patients with brohchial asthma, 4 with diffuse panbronchiolitis, 4 with pulmonary emphysema, 3 with allergic granulomatous angitis, each 1 with lung tuberculosis and with bronchiectasia. 2. Forty one patients (66.1%) out of the 62 cases had spa therapy. 3. Out of 32 patients coming from Tottori prefecture, 14 cases (43.8%) received spa therapy. On the other hand, spa therapy was carried out for 15 cases (88.2%) out of the 17 cases from Okayama prefecture, and for 12 cases (92.3%) out of the 13 cases from the other prefectures (long distant areas). 4. Spa therapy was effective in 27 cases (81.9%) out of the 33 patients with bronchial asthma. Spa therapy also effective for patients with diffuse panbronchiolitis, and allergic granulomatous angitis. kn-abstract=1988年1月より12月までの1年間に当院へ入院した慢性呼吸器疾患患者62例を対象に，背景因子，臨床的特徴および温泉療法の臨床効果について検討を加えた。1．対象62例のうちわけは，気管支喘息49例，瀰漫性汎細気管支炎4例，肺気腫4例，アレルギー性肉芽腫性血管炎3例，肺結核，気管支拡張症各1例であった。2．これら62症例のうち，温泉療法を受けた症例は41例（66.1％）であった。3．温泉療法を受けた症例の地域分布では，鳥取県からの入院症例32例では14例（43.8％）であり，同様に岡山県からの入院症例17例では15例（88.2％），その他の県からの入院症例13例では12例（92.3％）であった。4．温泉療法の臨床効果は，気管支喘息では33例中著効12例，有効15例，やや有効5例，無効1例で，明らかな有効例は27例（81.9％）であった。また温泉療法は瀰漫性汎細気管支炎，アレルギー性肉芽腫性血管炎などに対しても有効であった。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部三朝分院内科 en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=瀰漫性汎細気管支炎 (Diffuse panbronchiolitis) kn-keyword=瀰漫性汎細気管支炎 (Diffuse panbronchiolitis) en-keyword=アレルギー性肉芽腫性血管炎 (Allergic granulomatous angitis) kn-keyword=アレルギー性肉芽腫性血管炎 (Allergic granulomatous angitis) en-keyword=温泉療法 (Spa therapy) kn-keyword=温泉療法 (Spa therapy) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=14 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy for bronchial asthma. Effect of spa therapy on　adrenal glands function. kn-title=気管支喘息の温泉療法 ―温泉療法の副腎皮質機能に及ぼす影響― en-subtitle= kn-subtitle= en-abstract=Effect of spa therapy on adrenai glands function was studied in 30 patients with bronchial asthma, by observing serum cortisol levels. 1. The mean of serum cortisol levels was 5.64±4.95γ/dℓ in all cases, 2.25±2.51γ/dℓ in　15 cases with steroid dependent asthma and 9.02±4.47γ/dℓ in 15 cases without steroid therapy. There was a significant difference between the two groups (P<0.001). 2. Serum cortisol levels were measured before and after spa therapy for 1 to 3 months. The mean of serum cortisol levels increased from 5.26±4.98γ/dℓ before spa therapy, to 9.51±5.26γ/dℓ after spa therapy, which was significantly higher than the former (P<0.05). 3. Changes of serum cortisol levels after hot spring bath fot 20 min were observed. Serum cortisol levels seased in one group, and　did not change in the other groups after 20-min hot spring bath. In no change groups of serum cortisol levels, adrenocortical function was normal in one group, and highly damaged in the other group. kn-abstract=気管支喘息30症例を対象に，血中コーチゾール値を観察することにより，温泉療法の副腎皮質機能に及ぼす影響について検討を加えた。1．対象30症例の平均血中コーチゾール値は，5.64±4.95γ／dℓであった。このうち，ステロイド依存性喘息15例では，2.25±2.51γ／dℓ，ステロイド非使用の喘息15例では，9.02±4.47γ／dℓであり，ステロイド依存性喘息症例で有 意の低下傾向が見られた（P＜0.001）。2.1－3カ月間の温泉療法前後での比較では，療法前の平均血中コーチゾール値は5.26±4.98γ／dℓ，後では9.51±5.26γ／dℓであり，温泉療法により有意の上昇がみられた（P＜0.05）。3.1回の温泉浴前後の血中コーチゾール値の変動では，変動のみられない群と上昇傾向を示す群の2つの症例群が観察された。このうち，変動のみられない症例群は，もともと血中コーチゾール値が正常であるか，あるいは副腎皮質機能が疲弊してしまっているかのいずれかであった。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学三朝分院内科 en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=血中コーチゾール (Serum cortisol level) kn-keyword=血中コーチゾール (Serum cortisol level) en-keyword=温泉浴 (Hot spring bath) kn-keyword=温泉浴 (Hot spring bath) en-keyword=温泉療法 (Spa therapy) kn-keyword=温泉療法 (Spa therapy) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=19 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy for bronchial asthma-Clinical effects of inhalation of iodine salt soluions. kn-title=気管支喘息の温泉療法 ―ヨードゾル吸入療法の臨床効果― en-subtitle= kn-subtitle= en-abstract=Clinical effects of inhalation therapy by iodine salt solutions were studied in 20 patients with bronchial asthma. 1. Inhalation therapy by iodine salt solutions was markedly effective in 4 cases (20%), moderately in 11 cases (55%), slightly in 4 cases (20%) and not effective in 1 case (5 % ). Number of the effective cases was 6 (66.7%) out of 9 cases with bronchospasm type (Ⅰa), and 7 (77.8%) out of 9 cases with bronchospasm＋ hypersecretion type (Ⅰb), respectively. The inhalation therapy was also effective in all two cases with bronchiolar obstruction type (Ⅱ). 2. % Improvement of ventilatory function after inhalation of iodine salt solution was 8.5% in FVC, 11.0% in FEV(1.0), 9.7% in PEFR, 12.2% in MMF, 14.4% in V(50) and 14.8% in V(25). The % increase in ventilatory function was higher in the parameters such as MMF and V(25), representihg ventilatory disturbance of small airways. kn-abstract=気管支喘息20例を対象に，ヨードゾル吸入療法を行ない，その臨床効果について検討を加えた。1．ヨードゾル2週間吸入後の臨床効果判定では，著効4例（20％），有効11例（75％），やや有効4例（20％），無効1例（5％）であり，有効以上の明らかな有効例は20例中15例（75％）であった。また臨床病型別の効果の検討では，明らかな有効例は，Ⅰa．気管支攣縮型では9例中6例（66.7％），Ⅰb．気管支攣縮＋過分泌型では9例中7例（77.8％）であった。一方，Ⅱ．細気管支閉塞型では2例いずれも有効であった。2．ヨードゾル1回吸入後の換気機能の改善率は，FVC8.5％，FEV（1.0）11.0％，PEFR9.7％，MMF12.2％, V（50）14.4％， V（25）14.8％であり，閉塞性換気障害を示すパラメーターの改善率がやや高く，なかでも小さい気道の換気障害と関連の深いMMFやV（25）の改善率が高い傾向がみられた。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学三朝分院内科 en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=ヨードゾル吸入 (Inhalation of iodine salt sotutlon) kn-keyword=ヨードゾル吸入 (Inhalation of iodine salt sotutlon) en-keyword=温泉療法 (Spa therapy) kn-keyword=温泉療法 (Spa therapy) en-keyword=換気機能 (Ventilatory function) kn-keyword=換気機能 (Ventilatory function) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=25 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy for bronchial asthma -Clinicai studies on 93 cases with bronchial asthma- kn-title=気管支喘息の温泉療法 ―93例の臨床的検討― en-subtitle= kn-subtitle= en-abstract=Allergological characteristics and factors of spa therapy in relation to clinical effects were studied on 93 patients, who were adirnitted at Misasa Branch Hospital from 1982 to 1988. Fifty-seven out of 93 cases were steroid-dependent intractable asthma. 1. The mean age was 52.6 and the mean age at onset was 41.7 years old. The age and age at onset were higher ip these asthma cases. 2. The mean serum IgE levels was 506.2IU/mℓ. Serum IgE levels were generally low, and less than 300IU/mℓ in many cases. 3. Frequency of positive skin reactions to various allergens was generally low, and considerably higher in the two allergens, candida albicans and house dust. Cases with posiitive RAST score was most frequently observed in house dust, followed by candida albicans and J. cedar. 4. Ventilatory function tests of these patients showed that % V(50), % V(25)and % MMF which represent small airway obstruction were less decreased in bronchospasm type and most deereased in bronchiolar obstruction type. 5. The bronchospasm type was most frequently observed, followed by bronchospasm-hypersecretion type and bronchiolar obstruction type. 6. Spa therapy was effective in 74 cases (79.6%) out of the 93　patients, and regarding clinical classification of asthma type, spa therapy was most effective in the cases with bronchiolar obstruction type. kn-abstract=1982年1月から1988年12月までの7年間に三朝分院内科に入院し，温泉療法を受けた気管支喘息93例を対象に，その背景因子，免疫アレルギー学的要素および温泉療法の臨床効果について総合的に検討した。１．年齢の平均は52.6才，発症年齢の平均は41.7才であり，両者ともやや高齢であった。2．血清IgE値の平均は506.2IU／mℓであった。300IU／mℓ以下の症例は59例（63.4％）であり，半数以上の症例が血清IgE値正常ないし低値を示した。3．皮内反応ではカンジダに陽性を示す症例が44例と最も多く，次にハウスダスト（以下HDと略す）26例，スギ13例，キヌ8例であった。4．換気機能検査では気管支攣縮型において換気機能の低下傾向が最も少なく，細気管支閉塞型で換気機能の低下傾向が特に％ MMF，％ V（50），％　V（25）のような細気管支の閉塞を示すパラメーターの低下傾向がより高度であった。5．対象症例の臨床病型は気管支攣縮型が4７例でほぼ対象症例の半数を占め次いで気管支攣縮＋過分泌型29例，細気管支閉塞型17例の順であった。6．温泉療法の全般的有効率は79.6％であった。臨床病型別では細気管支閉塞型17例中16例（94.1％）が有効例であり，細気管支閉塞型で最も有効例がみられた。 en-copyright= kn-copyright= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=1 ORCID= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部三朝分院内科 en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=温泉療法 (Spa therapy) kn-keyword=温泉療法 (Spa therapy) en-keyword=臨床病型 (Asthma type) kn-keyword=臨床病型 (Asthma type) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=31 end-page=34 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Oxygen inhalation therapy for chronic venous ulcer. -An additional treatment modality- kn-title=難治な静脈性潰瘍に対する酸素療法 ―補助療法としての意義― en-subtitle= kn-subtitle= en-abstract=Prolonged venous hypertension leads to increase the number of dilated capillaries and to fibrin deposition around them which may form a barrier to the diffusion of oxygen and other nutrients from the blood to the tissue, so that cell death and ulceration may occur. Following inhalation of 100 % -O(2), increased partial pressure of subcutaneous tissue oxygen (pO(2)) around the ulcer was confirmed by means of medical mass spectrometry, which was found comparable to or higher than the level of ulcer-free area (chest) on room air. Four patients suffering from chroriic ulcers were successfully treated by 100 % -O(2) inhalation, 4-5 ℓ/min, for one hour every day in addition to the simpie measures of reducing venous stasis. Suffice it to say that the inhalation of 100 % -O(2) may be applicative to an additional treatment modality in chronic venous ulceration, though inhalation of 100 % -O(2) for a long period of time may not be recommended. kn-abstract=長期にわたり反復する静脈性潰瘍は，静脈圧亢進により拡張した毛細管の増加とその周辺に滲出したフィブリンの沈着により，血液からの酸素，及び栄養物の供給が妨げられている。医用質量分析装置による皮下組織ガス分圧の評価で経鼻的に100　％　の酸素吸入により潰瘍周辺への酸素供給が認められたので，重篤臨床例に対して静脈圧減圧処置に加えて酸素吸入を併用したところ，潰瘍の治癒傾向は著しく速くなり，補助療法としての意義を認めた。 en-copyright= kn-copyright= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=1 ORCID= en-aut-name=TokunouTeruo en-aut-sei=Tokunou en-aut-mei=Teruo kn-aut-name=得能輝男 kn-aut-sei=得能 kn-aut-mei=輝男 aut-affil-num=2 ORCID= en-aut-name=SodaMitsuhiro en-aut-sei=Soda en-aut-mei=Mitsuhiro kn-aut-name=曽田益弘 kn-aut-sei=曽田 kn-aut-mei=益弘 aut-affil-num=3 ORCID= en-aut-name=HiraiShunichi en-aut-sei=Hirai en-aut-mei=Shunichi kn-aut-name=平井俊一 kn-aut-sei=平井 kn-aut-mei=俊一 aut-affil-num=4 ORCID= en-aut-name=MorisueShinnhachi en-aut-sei=Morisue en-aut-mei=Shinnhachi kn-aut-name=森末真八 kn-aut-sei=森末 kn-aut-mei=真八 aut-affil-num=5 ORCID= en-aut-name=SuzukaIchio en-aut-sei=Suzuka en-aut-mei=Ichio kn-aut-name=鈴鹿伊智雄 kn-aut-sei=鈴鹿 kn-aut-mei=伊智雄 aut-affil-num=6 ORCID= en-aut-name=SunakawaMitsuru en-aut-sei=Sunakawa en-aut-mei=Mitsuru kn-aut-name=砂川満 kn-aut-sei=砂川 kn-aut-mei=満 aut-affil-num=7 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部付属環境病態研究施設リハビリテーション外科学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部付属環境病態研究施設リハビリテーション外科学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部付属環境病態研究施設リハビリテーション外科学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部付属環境病態研究施設リハビリテーション外科学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部付属環境病態研究施設リハビリテーション外科学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部付属環境病態研究施設リハビリテーション外科学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部付属環境病態研究施設リハビリテーション外科学分野 affil-num=8 en-affil= kn-affil=岡山大学医学部付属環境病態研究施設リハビリテーション外科学分野 en-keyword=慢性静脈性潰瘍 (Chronic venous ulcer) kn-keyword=慢性静脈性潰瘍 (Chronic venous ulcer) en-keyword=組織ガス分圧 (Partial pressure of tissue gases) kn-keyword=組織ガス分圧 (Partial pressure of tissue gases) en-keyword=医用質量分析装置 (Medical mass spectrometer) kn-keyword=医用質量分析装置 (Medical mass spectrometer) en-keyword=酸素拡散 (Oxygen diffusion) kn-keyword=酸素拡散 (Oxygen diffusion) en-keyword=酸素吸入療法 (Oxygen inhalation therapy) kn-keyword=酸素吸入療法 (Oxygen inhalation therapy) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=35 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Maternity swimmlng at Misasa Hospital of Okayama University Medical School. Second report. The indication and its practice. kn-title=岡山大学医学部附属病院三朝分院における妊婦水泳　第二報　妊婦水泳の適応とその実際 en-subtitle= kn-subtitle= en-abstract=From February to December, 1988, 18 cases of maternity swimming were deliverd at Misasa hospital of Okayama university medical school. Then we discussed the indication, safety and effectiveness of maternity swimmmg. (Results) (1) Fifteen cases (83.3%) were primiparas and 5 cases (27.8%) were 30 years old or more. (2) As for the weeks of pregnancy at the beginning of swimming, the earliest one was at 18 weeks and the latest one was at 37 weeks. (3) The times of swimming during pregnancy were variou in each case, and the maxirnum one was 20 times and the minimum one was 2 times. (4) There was no abortion and premature delivery. (5) There was no low birth weight infant and no asphxia of the newborn. (Conclusion) The inducement of maternity swimming is safe and effective to the management of pregnancy, especially to the cases of primipara, old aged or having minor disturbance. kn-abstract=第一報において，当科外来通院妊婦を対象とした妊婦水泳に関するアンケート調査の結果を報告1）したが，その結果にもとづき，1988年2月より妊婦水泳を開始し，11カ月を経過した。この間，初産婦および前回難産経験をもつ経産婦を主たる対象として，積極的に水泳を奨めた結果，18例の妊婦水泳を経験することができた。その結果，流早産例は1例もなく，児の予後も良好であり，妊婦管理の一環としての妊婦水泳の安全性と有用性が確認できたので，当科における妊婦水泳の現状とその適応につき報告する。 en-copyright= kn-copyright= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=1 ORCID= en-aut-name=KondouYuji en-aut-sei=Kondou en-aut-mei=Yuji kn-aut-name=近藤裕司 kn-aut-sei=近藤 kn-aut-mei=裕司 aut-affil-num=2 ORCID= en-aut-name=SakataJunko en-aut-sei=Sakata en-aut-mei=Junko kn-aut-name=坂田旬子 kn-aut-sei=坂田 kn-aut-mei=旬子 aut-affil-num=3 ORCID= en-aut-name=YosidaSachie en-aut-sei=Yosida en-aut-mei=Sachie kn-aut-name=吉田佐知江 kn-aut-sei=吉田 kn-aut-mei=佐知江 aut-affil-num=4 ORCID= en-aut-name=TanizakiYosiro en-aut-sei=Tanizaki en-aut-mei=Yosiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=妊婦水泳 (Maternity swimming) kn-keyword=妊婦水泳 (Maternity swimming) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=39 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical evaluation of co-examination by sigmoidoscopy and barium enema study for early diagnosis of colon cancer kn-title=大腸癌早期診断による注腸・内視鏡同日併用法 ―診断能および検査前日食の検討― en-subtitle= kn-subtitle= en-abstract=The present study was performed (1) to evaluate the validity of co-examination by sigmoidoscopy and barium enema study for the early diagnosis of colon cancer and (2) to find the most suitable preparation method for the co-examination. The co-examination was performed on 94 patients : those with abdominal symptoms and signs suggestive of colonic diseases : those with positive occult blood test in stool : or those asking for the routine examination of the colon. The examination revealed 5 cases of colon cancer (2 with early cancer and 3 with advanced cancer) and 26 eases (32 lesions) with colon polyp. The high detection rate of colonic neoplasms, especially of minute lesions, along with the high rate of early lesions among cancers suggested the validity of the co-examination method for the early diagnosis of colon cancer. The method was not time-consuming and not demanding for both patients and doctors, but was effective in detecting minute lesions by allowing a doublecheck in the high-risk recto-sigmpid region ; in addition, the upper colon could be examined by X-ray. The comparative studies on the currently popular Preparation method (modified Brown's method) and a new method with retort foods (Sankenclean, Sanwa Kagaku Kenkyusho Co., Ltd) revealed that the latter was significantly more effective in cleaning colon lumen and visualizing fine network pattern of the colonic mucosa. In addition, the patients were more satisfied with the taste of the latter. kn-abstract=注腸・内視鏡同日併用法の大腸早期癌診断における有用性の検討，その診断能向上のための検査前日食改善を目的に，同法を施行した94例の診断能，従来のBrown変法に準じた献立食とレトルト食（サンケンクリン）とのX線画像の質，内視鏡時の残渣の程度，被検者への味のアンケートを分析した。発見大腸腫瘍は癌5例（早期癌2例，進行癌3例），ポリープ26例32病変である。早期癌はともにポリープの形態をとり，注腸，内視鏡とも病変を指摘できた。病変の好発部位である直腸・S状結腸で注腸・内視鏡によるダブルチェックができる。前日食の検討ではレトルト食が従来の献立食と比し，注腸・内視鏡ともに優れた腸内洗浄能を有し，味のアンケートからも劣ることはなかった。大腸癌早期発見の2次スクリーニングとして，レトルト食を前日食とする同法の有用性が示された。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=IshibashiTadaaki en-aut-sei=Ishibashi en-aut-mei=Tadaaki kn-aut-name=石橋忠明 kn-aut-sei=石橋 kn-aut-mei=忠明 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=7 ORCID= en-aut-name=NakaiMutsurou en-aut-sei=Nakai en-aut-mei=Mutsurou kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=8 ORCID= en-aut-name=HayashimotoKanae en-aut-sei=Hayashimoto en-aut-mei=Kanae kn-aut-name=林本加奈枝 kn-aut-sei=林本 kn-aut-mei=加奈枝 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=5 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=6 en-affil= kn-affil=岡山大学医学部環境病態研究施設 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=大腸早期癌 (Ealry diagnosis of colon cancer) kn-keyword=大腸早期癌 (Ealry diagnosis of colon cancer) en-keyword=注腸・内視鏡同日併用法 (Co-examination by sigmoidoscopy and barium enema study) kn-keyword=注腸・内視鏡同日併用法 (Co-examination by sigmoidoscopy and barium enema study) en-keyword=大腸検査前処置 (Preparation for colon examination) kn-keyword=大腸検査前処置 (Preparation for colon examination) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=54 end-page=60 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on bronchial asthma induced by chironomid midges -comparison between positive and negative cases to house dust- kn-title=ユスリカ喘息に関する臨床的検討 ―HD陽性例および陰性例の比較検討― en-subtitle= kn-subtitle= en-abstract=In recent years it has been reported that chironomid migdes might be one of the causative allergens in bronchial asthma. In order to clarify the clinical characteristics of bronchial asthma induced by chironomid midges (Tokunagayusurika akamusi), 163 patients with bronchial asthma were studied. The subjects were divided into two groups ; cases with negative (0～1 + ) and positive (2 + or more) RAST score to house dust. 1. Skin reaction to midges was positive in 54 cases (33.1%) out of 163 patients with bronchial asthma. Thirty-six cases (43.9%) out of 82 asthmatics with positive RAST score to house dust showed positive skin reaction to midges, but in 81 cases with negative RAST score, only 18 cases (22.2%) showed positive skin reaction. 2. Fourteen cases out of 85 asthmatics showed a significant amount of histamine release (more than 15%).　A significant amount of histamine release was observed in 12 cases (23.5%) out of 51 cases with positive RAST score, but in only two cases (5.9%) out of 24 cases with negative RAST score. 3. Specific IgE antibodies to CTT (Chiromonus thummi thummi) was positive in 12 cases (18.2%) out of 66 asthmatics. In 41 asthmatics with positive RAST score to house dust, 12 cases (29.3%) showed positive RAST score to CTT, though in 25 cases with negative RAST score to house dust no cases showed positive RAST score to CTT. In conclusion, cases with house dust allergy were more easily sensitized by chironomid migdes than those cases without house dust allergy. kn-abstract=近年ユスリカが気管支喘息の原因抗原となり得ることが報告されている。しかし，その臨床的特徴はいまだ明らかにされていない。このユスリカ抗原の特徴を検討する目的で，気管支喘息症例163例をHD（ハウスダスト）に感作されたRAST　score2＋以上の陽性例82例とscore1＋以下の陰性例81例とに分けて比較検討を行なった。その結果皮膚反応，ヒスタミン遊離，CTT抗原を用いた特異的IgE抗体いずれの検討においても，HDに感作された症例が，よりユスリカ抗原にも感作されやすいことが明らかになった。 en-copyright= kn-copyright= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=1 ORCID= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= en-aut-name=TadaSinya en-aut-sei=Tada en-aut-mei=Sinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=5 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=6 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=7 ORCID= en-aut-name=MatsuokaHiroyuki en-aut-sei=Matsuoka en-aut-mei=Hiroyuki kn-aut-name=松岡裕之 kn-aut-sei=松岡 kn-aut-mei=裕之 aut-affil-num=8 ORCID= en-aut-name=IshiiAkira en-aut-sei=Ishii en-aut-mei=Akira kn-aut-name=石井明 kn-aut-sei=石井 kn-aut-mei=明 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学第二内科 affil-num=6 en-affil= kn-affil=岡山大学第二内科 affil-num=7 en-affil= kn-affil=岡山大学第二内科 affil-num=8 en-affil= kn-affil=岡山大学寄生虫学教室 affil-num=9 en-affil= kn-affil=岡山大学寄生虫学教室 en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=ユスリカ (Chironomid midges) kn-keyword=ユスリカ (Chironomid midges) en-keyword=ヒスタミン遊離 (Histamine release) kn-keyword=ヒスタミン遊離 (Histamine release) en-keyword=ハウスダスト (House dust) kn-keyword=ハウスダスト (House dust) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=61 end-page=66 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on serum cortisol levels in patients with intractable asthma kn-title=重症難治性喘息における副腎皮質ホルモン投与の影響 en-subtitle= kn-subtitle= en-abstract=In order to investigate adverse effects of steroid therapy on adrenocortical function and immune function, serum cortisol levels, peripheral lymphocytes' counts and serum immuno-globulin levels were examined in 65 asthmatic patients. The asthmatic patients were classified into 3 groups according to steroid therapy for the past 3 years ; group Ⅰ has been treated with continuous steroid therapy, group Ⅱ with occasional steroid therapy and group Ⅲ without steroid therapy. The results were as follows. 1. The mean of serum cortisol levels was lower significantly in group Ⅰ as compared with that in group Ⅲ, (groupⅠ:4.0μg/dℓ, groupⅢ:11.6μg/dℓ). 2. The average count of peripheral lymphocytes was more decreased in group Ⅰ than in group Ⅲ. The difference between the two groups was significantly, (group Ⅰ:1659/mm(3), group Ⅲ:2150/mm(3)). 3. The average levels of serum immunoglobinlins such as IgG, IgA and IgM was　 significantly lower in group Ⅰ compared with that in group Ⅲ, (group Ⅰ :IgG 1062mg/dℓ, IgA 218mg/dℓ, IgM 148mg/dℓ, group Ⅲ: IgG 1501mg/dℓ, IgA 279mg/de, IgM 227mg/dℓ). The results suggested that long-tetm steroid therapy remarkably suppressed adrenocortical function and immune function in patients with asthma. kn-abstract=重症難治性喘息におけるステロイド剤の副腎皮質機能，免疫能に及ぼす影響を調べるため，喘息患者65例を過去3年間のステロイド剤使用状況により，Ⅰ群：依存性症例，Ⅱ群：時に使用する症例，Ⅲ群：非使用例の3群に分け，血清コルチゾール値，末梢血リンパ球数及び血清免疫グロブリンについて検討した。結果は，血清コルチゾール値：Ⅰ群4.0μg／dℓ，Ⅲ群11.6μg／dℓ，末梢血リンパ球数：Ⅰ群1，659／mm（3）Ⅲ群2，150／mm（3），I gG：Ⅰ群1，062mg／dℓ，Ⅲ群1．501mg／dℓ，IgA：Ⅰ群218mg／dℓ，Ⅲ群279mg／dℓ，IgM：Ⅰ群148mg／dℓ，Ⅲ群227mg／dℓとⅠ群はⅢ群に比べ有意に低い平均値を示しステロイド剤の副腎皮質機能，免疫能への抑制作用が窺われた。また末梢血リンパ球数の減少は，高齢者のステロイド依存性例に顕著であった。 en-copyright= kn-copyright= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= en-aut-name=TadaSinya en-aut-sei=Tada en-aut-mei=Sinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=5 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=6 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=6 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=重症難治性喘息 (Intractable asthma) kn-keyword=重症難治性喘息 (Intractable asthma) en-keyword=血清コルチゾール (Serum cortisol) kn-keyword=血清コルチゾール (Serum cortisol) en-keyword=末梢血リンパ球 (Peripheral lymphocytes) kn-keyword=末梢血リンパ球 (Peripheral lymphocytes) en-keyword=血清免疫グロブリン (Serum immunoglobuiin) kn-keyword=血清免疫グロブリン (Serum immunoglobuiin) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=67 end-page=71 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Absolute ethanol injection for non-parasitic hepatic cyst. kn-title=非寄生虫性肝嚢胞に対する経皮的エタノール注入療法 ―有効3症例の検討― en-subtitle= kn-subtitle= en-abstract=Three patients suffering from nonparasitic hepatic cysts were successfully treated with absolute ethanol injection under ultrasonic guided puncture. As the procedure was simple and less invasive, it was considered that this treatment for hepatic cysts was an alternative to surgery.　However, more than one month was needed, untill remqrkable shrinkage of cysts was expected in all three patients. kn-abstract=非寄生虫性肝嚢胞の3例に，超音波ガイド下にドレナージ及び純エタノール注入を行い，全例に嚢胞の著明な縮小効果を認めた。本法は手技も容易で，副作用も軽微であり，エタノール注入と嚢胞縮小効果の間には1カ月以上の時間的な経過を要するが，肝嚢胞に対して，外科的療法に代わる有用な治療法であると思われる。 en-copyright= kn-copyright= en-aut-name=MorisueShinhachi en-aut-sei=Morisue en-aut-mei=Shinhachi kn-aut-name=森末真八 kn-aut-sei=森末 kn-aut-mei=真八 aut-affil-num=1 ORCID= en-aut-name=SuzukaIchio en-aut-sei=Suzuka en-aut-mei=Ichio kn-aut-name=鈴鹿伊智雄 kn-aut-sei=鈴鹿 kn-aut-mei=伊智雄 aut-affil-num=2 ORCID= en-aut-name=HiraiShunichi en-aut-sei=Hirai en-aut-mei=Shunichi kn-aut-name=平井俊一 kn-aut-sei=平井 kn-aut-mei=俊一 aut-affil-num=3 ORCID= en-aut-name=SodaMitshiro en-aut-sei=Soda en-aut-mei=Mitshiro kn-aut-name=曽田益弘 kn-aut-sei=曽田 kn-aut-mei=益弘 aut-affil-num=4 ORCID= en-aut-name=TokunoTeruo en-aut-sei=Tokuno en-aut-mei=Teruo kn-aut-name=得能輝男 kn-aut-sei=得能 kn-aut-mei=輝男 aut-affil-num=5 ORCID= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=6 ORCID= en-aut-name=SunakawaMitsuru en-aut-sei=Sunakawa en-aut-mei=Mitsuru kn-aut-name=砂川満 kn-aut-sei=砂川 kn-aut-mei=満 aut-affil-num=7 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=8 ORCID= en-aut-name=KomatsubaraShokichi en-aut-sei=Komatsubara en-aut-mei=Shokichi kn-aut-name=小松原正吉 kn-aut-sei=小松原 kn-aut-mei=正吉 aut-affil-num=9 ORCID= en-aut-name=TeramotoShigeru en-aut-sei=Teramoto en-aut-mei=Shigeru kn-aut-name=寺本滋 kn-aut-sei=寺本 kn-aut-mei=滋 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=8 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=9 en-affil= kn-affil=岡山大学第二外科 affil-num=10 en-affil= kn-affil=岡山大学第二外科 en-keyword=肝嚢胞 (Liver cyst) kn-keyword=肝嚢胞 (Liver cyst) en-keyword=超音波ガイド下穿刺術 (Ethanol injection) kn-keyword=超音波ガイド下穿刺術 (Ethanol injection) en-keyword=エタノール注入療法 (Transcutaneous hepatic puncture) kn-keyword=エタノール注入療法 (Transcutaneous hepatic puncture) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=72 end-page=75 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Radiation horrnesis with Radon baths kn-title=ラドン泉ホルミシス en-subtitle= kn-subtitle= en-abstract=Radon bathings is indicated for chronic pain caused by degenerative changes in connective tissues by warming effect as a result of the improvement in tissue perfusion based on the experimental inhalation study for high concentration of Radon (13,764-23,743 Bq/ℓ). Radioactive radiation has been thought to be bio-negative in general. The environmental radiation in Misasa hospital of 80.7±7.8mBq/ℓ and 265.8±98.8mBq/ℓ in the steam bath room (727-2,395% of Rn-free district) may contribute on Rn spa therapy, as we have no experiences of bio-negative effects of Rn on epidemiology study. It seems probable that the early data of cosmic radiation effects to promote reproduction rate on the primitive organisms have significance and that the ambient radiation is essential for normal physiological function and life of the living organisms. In order to share the benefit of hormetic effects (hormesis) with Radon springs, optimal dosis should be determined together with the development of precise micro-dosimetry. kn-abstract=ラドン泉浴の保温作用は，薬効的には高濃度（13,764－23,743Bq／ℓ）ラドンの吸入による組織循環の改善による。ラドンによる脈管作動的機序はなお明らかにし得ていないが，末梢循環改着作用に基づく保温効果は疲労回復，及び退行性変性の慢性疼痛緩解に適応を有する。生物に対する放射能は，すべて有害とする認識が一般的であるが，自然放射能を含めてその刺激作用によりbio-positiveの恩恵を受けている。ラドン泉浴によるbio-negativeの報告も見られる中で，ホメオスターシスの維持に必要なbio-positiveなhormetic effectsとしての刺激作用の解明が望まれる。 en-copyright= kn-copyright= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=1 ORCID= en-aut-name=TokunohTeruo en-aut-sei=Tokunoh en-aut-mei=Teruo kn-aut-name=得能輝男 kn-aut-sei=得能 kn-aut-mei=輝男 aut-affil-num=2 ORCID= en-aut-name=SodaMitsuhiro en-aut-sei=Soda en-aut-mei=Mitsuhiro kn-aut-name=曽田益弘 kn-aut-sei=曽田 kn-aut-mei=益弘 aut-affil-num=3 ORCID= en-aut-name=HiraiShunichi en-aut-sei=Hirai en-aut-mei=Shunichi kn-aut-name=平井俊一 kn-aut-sei=平井 kn-aut-mei=俊一 aut-affil-num=4 ORCID= en-aut-name=MorisueShinhachi en-aut-sei=Morisue en-aut-mei=Shinhachi kn-aut-name=森末真八 kn-aut-sei=森末 kn-aut-mei=真八 aut-affil-num=5 ORCID= en-aut-name=SuzukaIchio en-aut-sei=Suzuka en-aut-mei=Ichio kn-aut-name=鈴鹿伊智雄 kn-aut-sei=鈴鹿 kn-aut-mei=伊智雄 aut-affil-num=6 ORCID= en-aut-name=SunakawaMitsuru en-aut-sei=Sunakawa en-aut-mei=Mitsuru kn-aut-name=砂川満 kn-aut-sei=砂川 kn-aut-mei=満 aut-affil-num=7 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=8 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 en-keyword=ラドン泉 (Radon springs) kn-keyword=ラドン泉 (Radon springs) en-keyword=適応症 (lndications) kn-keyword=適応症 (lndications) en-keyword=放射能泉 (Radioactive springs) kn-keyword=放射能泉 (Radioactive springs) en-keyword=ホルミシス (Hormesis) kn-keyword=ホルミシス (Hormesis) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=76 end-page=82 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Interstitial matrix components in relation to the pathogenesis of fibrosis kn-title=細胞間マトリックスの構成成分と線維化 en-subtitle= kn-subtitle= en-abstract=Increasing numbers of patients with chronic pancreatitis have been reported all over the world, including Japan. Pathogenesis of chronic pancreatitis has remained to be revealed and the early detection has remaind difficult despite extensive investigations. Interstitial fibrosis forms one of the most important histopathological features of chronic pancreatitis along with loss of parenchyma and irregular dilatation of the ducts and ductules. However, only a limited numbers of reports have been pubiished on the pathogenetic mechanisms of interstitial fibrosis of the pancres, because tissue materials are not easily accessible and blood samples can hardly reflect the fibrotic process of the pancreas unlike the case of the iiver. Our Preliminary studies revealed that biochemical and immunochemical analysis of pure pancreatic juice, such as determination of collagen, hexosamine, fibronectin and proline hydroxylase, might reflect the fibrotic process of the pancreas. The results led us to review the earlier reports on inter-cellular matrix in relation to the formation of fibrosis to find suitable markers to be evaluated in the future systematic investigations. The review revealed that pure pancreatic juice should be analyzed for collagen, types of collagen, hexosamine, dermatan sulfate, fibronectin, larninin, proline hydroxylase, collagenase and cathepsin B(1). kn-abstract=慢性膵炎の症例は近年増加の一途をたどっており，その発症機序と病態の解明および対策の確立が急がれている。慢性膵炎の重要な所見の一つである膵間質線維化の発生機序の解明および早期発見法の確立は重要な課題であるが，従来の知見は断片的にすぎない。そこで，筆者らは膵線維化の系統的な研究を始めるにあたって，細胞間マトリックスの構成成分と線維化に関する従来の知見および今後の課題を整理した。細胞間マトリックスのうちでも特にコラーゲン，グリコサミノグリカン，フィブロネクチンをとりあげ，その構造と機能および組織の線維化形成における役割について文献的考察を行った。今後，膵組織および膵液中のプロリンハイドロキシラーゼ，コラーゲンとその型別分布および各型コラーゲンの比，ヘキソサミン，デルマタン硫酸，フィブロネクチン，ラミニンを検討することが重要と思われた。 en-copyright= kn-copyright= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=4 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=5 ORCID= en-aut-name=IshibashiTadaaki en-aut-sei=Ishibashi en-aut-mei=Tadaaki kn-aut-name=石橋忠明 kn-aut-sei=石橋 kn-aut-mei=忠明 aut-affil-num=6 ORCID= en-aut-name=TakedaMasahiko en-aut-sei=Takeda en-aut-mei=Masahiko kn-aut-name=武田正彦 kn-aut-sei=武田 kn-aut-mei=正彦 aut-affil-num=7 ORCID= en-aut-name=MiyakeHirofumi en-aut-sei=Miyake en-aut-mei=Hirofumi kn-aut-name=三宅啓文 kn-aut-sei=三宅 kn-aut-mei=啓文 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=8 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=慢性膵炎 (Chronic pancreatitis) kn-keyword=慢性膵炎 (Chronic pancreatitis) en-keyword=膵の線維化 (Interstitial fibrosis of the pancreas) kn-keyword=膵の線維化 (Interstitial fibrosis of the pancreas) en-keyword=膵間質成分 (Interstitial matrix of the pancreas) kn-keyword=膵間質成分 (Interstitial matrix of the pancreas) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=83 end-page=93 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Classification and concepts of pancreatitis kn-title=膵炎の分類 ―その変遷と最近の考え方― en-subtitle= kn-subtitle= en-abstract=The present paper is a review of the historical changes in the classification and concept of pancreatitis. The Marseille classification and concept had enjoyed its international popularity for more than 20 years since it was adopted at the first Marseille symposium in 1962. However, the recent advancement in the study of the pancreas led to the attempts to revise the classification and concept of pancreatitis ： International Symposium in Cambridge in 1983, Second International Symposium in Marseille in 1984 and Symposium at the International Congress of Gastroenterology in Rome in 1988. As one of us was invited to the last two symposia, we described the details of the revised classification and concept of Marseille (1984) and of Marseille-Rome (1988) ; then, we described the similarities and differences between the Cambridge classification, the revised Marseille classification and the Marseille-Rome classification. Finally we summarized the subjects to be further investigated to make better classification of pancreatitis in the future. kn-abstract=膵炎の分類は膵臓研究の進歩とともに変遷を重ねたが，ここ20年間はマルセイユ分類（1963年）が国際的に広く用いられてきた。しかし最近，膵検査法の進歩と膵研究の知見の蓄積を背景にして，ケンブリッジ（1983年），マルセイユ（1984年），およびローマ（1988年）において分類の改訂を目的に国際シンポジウムが開催され，それぞれに新しい膵炎の分類が提案された。各分類には多くの共通点が見られるが重要な相違点もある。各分類を十分に理解していないとしばらくは混乱に陥ることが危惧される。幸い筆者の1人はこれらのシンポジウムに招待され参加する機会を得たので，成文の背景にある討議を詳しく紹介し，各分類を比較しながらその特徴を述べた。それとともに将来理想的な分類を完成するために今後検討すべき課題をも指摘した。そして，これら分類の当面の利用法に関する筆者らの提案を述べた。 en-copyright= kn-copyright= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=1 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=4 ORCID= en-aut-name=IshibashiTadaaki en-aut-sei=Ishibashi en-aut-mei=Tadaaki kn-aut-name=石橋忠明 kn-aut-sei=石橋 kn-aut-mei=忠明 aut-affil-num=5 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=6 ORCID= en-aut-name=MiyakeHirofumi en-aut-sei=Miyake en-aut-mei=Hirofumi kn-aut-name=三宅啓文 kn-aut-sei=三宅 kn-aut-mei=啓文 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=膵炎 kn-keyword=膵炎 en-keyword=分類 (Classification and concepts of pancreatitis) kn-keyword=分類 (Classification and concepts of pancreatitis) en-keyword=急性膵炎 (Acute pancreatitis) kn-keyword=急性膵炎 (Acute pancreatitis) en-keyword=慢性膵炎 (Chronic pancreatitis) kn-keyword=慢性膵炎 (Chronic pancreatitis) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=94 end-page=99 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case report of linitis plastica type of colon cancer. kn-title=腟擦過細胞診で確認されたびまん浸潤型大腸癌 en-subtitle= kn-subtitle= en-abstract=A 43-year-old women, complaining of abdominal pain and menstrual irregularity was found suffering from adenocarcinoma of the transverse colon by cytology tests for vaginal smear and ascites. She was operated for colonic obstruction palliatively because of the extensive lesions and died 2 months after surgery for all that of the intensive cancer therapy. The histological diagnosis was primary linitis plastica type of carcinoma of the transverse colon. Carcer involvement to the ovaries and uterine tubes could possibly be responsible for the positive cytology test for vaginal smear. This rare type of careinoma demonstrates certain clinicopathological characteristics that differ from those of the ordinary colonic carcinomas, such as unfavourable prognosis with the difficulty for diagnosis due to minimal mucosal changes and the marked thickend wall of the tumor being unable to perform endoscopic studies. kn-abstract=原発性びまん浸潤型大腸癌は，全大腸癌症例の1％未満と比較的稀な疾患であり，一般大腸癌症例とくらべてその予後の悪いことで知られている。その原因の一つとして，確定診断の困難さがあるが，これは粘膜病変の欠如のために生検で確論がつきにくい点にある。我々の症例は，43歳の女性で，横行結腸に原発した症例である。腹痛を訴えて入院後，急速にイレウス状態となり，注腸検査で横行結腸の高度な狭窄を認めた。大腸ファイバースコープは腹痛のため病変部まで届かず，膣擦過細胞診およびダグラス窩穿刺腹水細胞診にて腺癌細胞を確認できた。手術所見はP（3）H（0）S（3）N（4）で，姑息切除に終わった。本症は手術時の進行度がきわめて高度であるので，本症を疑って確診のつかない症例には，上記のような細胞診も試みてみるべきと思われる。 en-copyright= kn-copyright= en-aut-name=HiraiShunichi en-aut-sei=Hirai en-aut-mei=Shunichi kn-aut-name=平井俊一 kn-aut-sei=平井 kn-aut-mei=俊一 aut-affil-num=1 ORCID= en-aut-name=SuzukaIchio en-aut-sei=Suzuka en-aut-mei=Ichio kn-aut-name=鈴鹿伊智雄 kn-aut-sei=鈴鹿 kn-aut-mei=伊智雄 aut-affil-num=2 ORCID= en-aut-name=MorisueShinhachi en-aut-sei=Morisue en-aut-mei=Shinhachi kn-aut-name=森末慎八 kn-aut-sei=森末 kn-aut-mei=慎八 aut-affil-num=3 ORCID= en-aut-name=SodaMitsuhiro en-aut-sei=Soda en-aut-mei=Mitsuhiro kn-aut-name=曽田益弘 kn-aut-sei=曽田 kn-aut-mei=益弘 aut-affil-num=4 ORCID= en-aut-name=TokunoTeruo en-aut-sei=Tokuno en-aut-mei=Teruo kn-aut-name=得能輝男 kn-aut-sei=得能 kn-aut-mei=輝男 aut-affil-num=5 ORCID= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=6 ORCID= en-aut-name=SunakawaMitsuru en-aut-sei=Sunakawa en-aut-mei=Mitsuru kn-aut-name=砂川満 kn-aut-sei=砂川 kn-aut-mei=満 aut-affil-num=7 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大塚昭雄 kn-aut-sei=大塚 kn-aut-mei=昭雄 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=8 en-affil= kn-affil=岡山大学医学部環境病態研究施設リハビリテーション外科学分野 affil-num=9 en-affil= kn-affil=平田市立病院外科 en-keyword=びまん浸潤型大腸癌 kn-keyword=びまん浸潤型大腸癌 en-keyword=スキルス大腸癌 (Scirrhous Carcinoma of the Colon) kn-keyword=スキルス大腸癌 (Scirrhous Carcinoma of the Colon) en-keyword=Ⅳ型大腸癌 kn-keyword=Ⅳ型大腸癌 en-keyword=Linitis Plastica型大腸癌 (Linitis Plastica Type of Carcinoma) kn-keyword=Linitis Plastica型大腸癌 (Linitis Plastica Type of Carcinoma) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=100 end-page=102 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analytic study on colon examination for the past three years. kn-title=当院における大腸検査の検討 ―過去3年間のデータの分析― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=1 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属三朝分院放射線室 affil-num=2 en-affil= kn-affil=岡山大学医学部附属三朝分院放射線室 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設 END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=103 end-page=107 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Application of personal computer system in nursing division. -(1) Programming for a roster- kn-title=看護部におけるパソコン活用（第一報）勤務表作成プログラムの試作 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=1 ORCID= en-aut-name=YoshidaJunko en-aut-sei=Yoshida en-aut-mei=Junko kn-aut-name=吉田順子 kn-aut-sei=吉田 kn-aut-mei=順子 aut-affil-num=2 ORCID= en-aut-name=InagakiKikuko en-aut-sei=Inagaki en-aut-mei=Kikuko kn-aut-name=稲垣喜久子 kn-aut-sei=稲垣 kn-aut-mei=喜久子 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=111 end-page=135 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On climatology in Misasa spa (11th report) kn-title=三朝温泉地の気候について（第11報） en-subtitle= kn-subtitle= en-abstract=Climatological data of the last 12 months (1987.4.1-1988.3.31) obtained by the climate autorecording system at the Misasa Medical Branch in Misasa spa, Tottori-Ken, Japan, are presented. kn-abstract=われわれは1956年以降，三朝温泉地の気候要素について観測を行ってきているが，今回は第11報として，ひきつづき1987年4月1日から1988年3月末日までの1ヵ年の気象観測の資料を報告することとした。なお1985年4月1日以降は自動記録装置が備えられたので，今回の資料はすべてこの自動記録装置によるものである。 en-copyright= kn-copyright= en-aut-name=MatsubaraFumie en-aut-sei=Matsubara en-aut-mei=Fumie kn-aut-name=松原扶美恵 kn-aut-sei=松原 kn-aut-mei=扶美恵 aut-affil-num=1 ORCID= en-aut-name=EndoHiroi en-aut-sei=Endo en-aut-mei=Hiroi kn-aut-name=遠藤裕井 kn-aut-sei=遠藤 kn-aut-mei=裕井 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=表紙・目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=108 end-page=110 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=看護部活動報告 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三朝分院看護部 kn-aut-sei=三朝分院看護部 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=136 end-page=152 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=1988年（1月～12月）業績集 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=投稿規定 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=裏表紙・英文目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=英文目次・裏表紙 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=投稿規定 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=表紙・目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=7 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy for chronic respiratory diseases - in subjects admitted in 1989. - kn-title=慢性呼吸器疾患の温泉療法 en-subtitle= kn-subtitle= en-abstract=Backgrounds and immunological characteristics were studied in patients with chronic respiratory diseases admitted at Misasa Branch Hospital in 1989. At the same time, clinical effects of spa therapy were evaluated for these patients. 1. Eighty five patients with chronic respratory diseases comprised 65 patients with bronchial asthma, 4 with pulmonary emphysema, 4 with lung tuberculosis, 3 with allergic granulomatous angitis, 3 with obstructive bronchiolitis, 2 with bronchiectasia, 2 with chronic bronchitis and 2 with hypersensitivity pneumonitis. 2. Sixty three patients (74.1%) out of the 85 cases had spa therapy. 3. Out of 51 patients coming from Tottori prefecture, 32 cases (62.7%) received spa therapy. On the other hand, spa therapy was carried out for 19 cases (95.0%) out of the 20 cases from Okayama prefecture, and for 12 cases (85.7%) out of the 14 cases from the other prefectures (long distant areas). 4. Many cases with bronchial asthma showed low serum levels of IgE (lower than 200 IU/ml), and frequency of positive skin reactions to various allergens was low in the patients with bronchial asthma. Serum cortisol levels were very low in patients with steroid-dependent asthma. 5. Spa therapy was effective in 41 cases (80.3%) out of the 51 patients with bronchial asthma. Spa therapy also effective for patients with obstructive bronchiolitis, and allergic granulomatous angitis. kn-abstract=1989年1月より12月までの1年間に当院へ入院した慢性呼吸器疾患患者85例（延べ90例）を対象に，その背景因子，臨床的特徴，および温泉療法の臨床効果について検討を加えた。(1)対象85例のうちわけは，気管支喘息65例，肺気腫4例，肺結核症4例，アレルギー性肉芽腫性血管炎3例，閉塞性細気管支炎3例，気管支拡張症2例，慢性気管支炎2例，過敏性肺臓炎2例であり，昨年度と異なり肺結核がやや多かったことが特徴的であった。(2)これら85症例のうち，温泉療法を受けた症例は63例(74.1％)であった。(3)温泉療 法を受けた症例の地域分布では，鳥取県からの入院症例51例では32例(62.7％)であり，同様に岡山県からの入院症例20例では19例(95.0％)，その他の県からの入院症例14例で12例(85.7％)であった。4．温泉療法の臨床効果は，気管支喘息では51例中著効14例，有効27例，やや有効8例，無効2例であり，明らかな有効例は41例（80.3％)であった。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=4 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=5 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=6 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=7 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=閉塞性細気管支炎 (Obstructive bronchiolitis) kn-keyword=閉塞性細気管支炎 (Obstructive bronchiolitis) en-keyword=慢性気管支炎 (Chronic bronchitis) kn-keyword=慢性気管支炎 (Chronic bronchitis) en-keyword=血清コーチゾール値 (Serum cortisol level) kn-keyword=血清コーチゾール値 (Serum cortisol level) en-keyword=温泉療法 (Spa therapy) kn-keyword=温泉療法 (Spa therapy) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=138 end-page=142 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case report of appendiceal calculus presented as abdominal tumor kn-title=腹部腫瘤を主訴とした虫垂結石の一例 en-subtitle= kn-subtitle= en-abstract=Appendiceal calculi are found in the only several percent of patients with appendicitis and have been known to be complicated in severe appendicitis or perforated peritonitis. We reported a 41-year-old female patient, whose initial symptom was right lower abdominal tumor of insidious growing. Abdominal examination revealed a small fist sized hard mass in the right lower abdomen with slight tenderness, and free of rebound tenderness and muscle defence. Abdominal ultrasonography and computed tomography showed that the tumor had continuity with appendix and contained calcification inside. Accordingly, she was diagnosed to have an appendiceal neoplasm and operated on. Post-operative diagnosis was appendiceal abscess with a calculus, 1 centimeter in diameter. It is rare that appendiceal calculi manifest a palpable abdominal tumor like this case. kn-abstract=虫垂結石は虫垂炎手術例の数％に見られるに過ぎないが，穿孔性腹膜炎などの重篤な炎症を招く可能性が高いことで知られている。自験例は41才の女性で，右下腹部腫瘤を主訴として来院した。画像診断で腫瘤は虫垂に連続し，内部に石灰化を認めたが，腫瘤が硬く，虫垂炎症状が軽微であったことから，虫垂原発腫瘍を疑い手術を行ったところ，虫垂膿瘍を併発した虫垂結石であった。本症が自験例のように触知可能な腹部腫瘤を形成することは比較的まれである。 en-copyright= kn-copyright= en-aut-name=SuzukaIchio en-aut-sei=Suzuka en-aut-mei=Ichio kn-aut-name=鈴鹿伊智雄 kn-aut-sei=鈴鹿 kn-aut-mei=伊智雄 aut-affil-num=1 ORCID= en-aut-name=HiraiShunichi en-aut-sei=Hirai en-aut-mei=Shunichi kn-aut-name=平井俊一 kn-aut-sei=平井 kn-aut-mei=俊一 aut-affil-num=2 ORCID= en-aut-name=MorisueShinhachi en-aut-sei=Morisue en-aut-mei=Shinhachi kn-aut-name=森末真八 kn-aut-sei=森末 kn-aut-mei=真八 aut-affil-num=3 ORCID= en-aut-name=SodaMitsuhiro en-aut-sei=Soda en-aut-mei=Mitsuhiro kn-aut-name=曽田益弘 kn-aut-sei=曽田 kn-aut-mei=益弘 aut-affil-num=4 ORCID= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=5 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 en-keyword=虫垂結石 (Appendiceal calculus) kn-keyword=虫垂結石 (Appendiceal calculus) en-keyword=腹部腫瘤 (Abdominal tumor) kn-keyword=腹部腫瘤 (Abdominal tumor) en-keyword=急性虫垂炎 (Acute appendicitis) kn-keyword=急性虫垂炎 (Acute appendicitis) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=129 end-page=133 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of atopic asthma characterized by marked neutrophilia in BALF kn-title=気管支肺胞洗浄液（BALF）中に高度の好中球増多の見られたアトピー型喘息の一例 en-subtitle= kn-subtitle= en-abstract=The clinical course and characteristics of a case with atopic asthma, showing marked neutrophilia in BALF and severe asthma attacks, were observed the frequency of neutrophils in BALF decreased followed by the improvement of her asthma attacks with therapy. The frequency of neutrophils in BALF was 65.4% at the initial stage before the therapy and decreased to 5.6% at attackfree stage after the therapy. The changes in frequency of neutrophils in BALF, obserbed in this case, should be noticed, because the cell in BALF were hardly affected by any treatment. kn-abstract=気管支肺胞洗浄液（BALF）中に高度の好中球の増多が見られ，治療により臨床症状の軽快と共にBALF中の好中球の減少を認めたアトピー型喘息の一例を経験した。経過中5回施行したBALF中の好中球百分率はそれぞれ65.4％，56.2％，42.4％，5.6％，5.6％であり，4回目，5回目では著明な好中球減少を認めた。本症例の如き症例は今後増加することが予想され，その発症病態を含め今後さらに症例を重ねて検討して行く必要があると 考えられた。 en-copyright= kn-copyright= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshirou en-aut-sei=Tanizaki en-aut-mei=Yoshirou kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= en-aut-name=KataokaHisakazu en-aut-sei=Kataoka en-aut-mei=Hisakazu kn-aut-name=片岡久和 kn-aut-sei=片岡 kn-aut-mei=久和 aut-affil-num=6 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=7 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=アトピー型喘息 (Atopic asthma) kn-keyword=アトピー型喘息 (Atopic asthma) en-keyword=好中球 (Neutrophil) kn-keyword=好中球 (Neutrophil) en-keyword=気管支肺胞洗浄法 (Bronchoaiveolar lavage) kn-keyword=気管支肺胞洗浄法 (Bronchoaiveolar lavage) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=147 end-page=167 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On climatology in Misasa spa (twelfth report） kn-title=三朝温泉地の気候について（第12報） en-subtitle= kn-subtitle= en-abstract=Climatological data of the last 12 months (1988.1.1－1988.12.31） obtained by the climate　autorecording　system at the Misasa Medical Branch in Misasa spa, Tottori－Ken, Japan, are presented. kn-abstract=われわれは1956年以降，三朝温泉地の気候要素について観測を行ってきているが，今回は第12報として，ひきつづき1988年1月1日から1988年12月末日までの1ヵ年の気象観測の資料を報告することとした。なお1985年4月1日以降は自動記録装置が備えられたので，今回の資料はすべてこの自動記録装置によるものである。 en-copyright= kn-copyright= en-aut-name=MatsubaraFumie en-aut-sei=Matsubara en-aut-mei=Fumie kn-aut-name=松原扶美恵 kn-aut-sei=松原 kn-aut-mei=扶美恵 aut-affil-num=1 ORCID= en-aut-name=EndouHiroi en-aut-sei=Endou en-aut-mei=Hiroi kn-aut-name=遠藤裕井 kn-aut-sei=遠藤 kn-aut-mei=裕井 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=134 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of malignant lymphoma of the small intestine kn-title=原発性小腸悪性リンパ腫の一例 en-subtitle= kn-subtitle= en-abstract=A 60 - year-old man complaining of right lower abdominal pain was sent to the operating room for acute appendicitis. The ileocoecal resection was performed for ulceration of the terminal ileum, which was diagnosed as an intestinal malignant lymphoma histologically. The case, therefore, was re-operated three weeks after the first operation. The right half of colon, and about 70 centimeters of ileum with their regional lymphnodes were resected. The case was revealed as the first stage of clinical classification by Naqvi et al. Up to the present time, 7 months after the first operation, there were no sIgns of reccurence. Intestinal malignant lymphoma somtimes has need to do an emergency oparation, and reoperation should be done without hesitation, if necessary. kn-abstract=原発性小腸悪性リンパ腫は，術前診断が困難で予後が悪い，比較的希な疾患である。我我の症例は60歳の男性で，右下腹部痛にて来院し，急性虫垂炎の診断で手術を施行した。手術時，回腸末端部より10cm口側に潰瘍性病変を認め，クローン病を疑って回盲部切除を施行した。病理組織検査にて悪性リンパ腫，difuse，medium sized cell typeと診断され，広範回腸切除を含む右記結腸切除及び所属リンパ節郭清を行った。リンパ節転移は認めず，stage I，治癒切除と考えられた。術後7カ月現在，再発の徴候無く外来通院中である。本症は5年生存率22～40％と茅後の悪い疾患であるが，stage I・IIとstage III・IV，治癒切除と非治癒切除の生存率には明かな差があり，早期の診断と根治切除の重要性を示唆している。また本症は，緊急手術を要する場合や自験例のごとく急性虫垂炎の診断で手術を受けることが少なからずあると思われ，根治切除に確信のもてない場合は再手術をためらってはならないと考える。 en-copyright= kn-copyright= en-aut-name=HiraiShunichi en-aut-sei=Hirai en-aut-mei=Shunichi kn-aut-name=平井俊一 kn-aut-sei=平井 kn-aut-mei=俊一 aut-affil-num=1 ORCID= en-aut-name=SuzukaIchio en-aut-sei=Suzuka en-aut-mei=Ichio kn-aut-name=鈴鹿伊智雄 kn-aut-sei=鈴鹿 kn-aut-mei=伊智雄 aut-affil-num=2 ORCID= en-aut-name=MorisueShinhachi en-aut-sei=Morisue en-aut-mei=Shinhachi kn-aut-name=森末慎八 kn-aut-sei=森末 kn-aut-mei=慎八 aut-affil-num=3 ORCID= en-aut-name=SodaMitsuhiro en-aut-sei=Soda en-aut-mei=Mitsuhiro kn-aut-name=曽田益弘 kn-aut-sei=曽田 kn-aut-mei=益弘 aut-affil-num=4 ORCID= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=5 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 en-keyword=小腸悪性リンパ腫 (Malignant lymphoma of the small intestine) kn-keyword=小腸悪性リンパ腫 (Malignant lymphoma of the small intestine) en-keyword=小腸悪性腫瘍 (Malignant tumor of the small intestine) kn-keyword=小腸悪性腫瘍 (Malignant tumor of the small intestine) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=123 end-page=128 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Development of stepping measurement device for evaluation of and training in walking kn-title=群性膵炎の発症原因の検索中に発見された小膵癌の検討 en-subtitle= kn-subtitle= en-abstract=Although gait training equipment such as the bicycle ergometer and treadmill exists for patients whose walking ability is high, there is no appropriate gait training mehtod or training instrument for patients whose walking ability has become impaired, who often use a cane or walker, etc. in the course of daily life. In the case of gait training for persons whose walking ability involves impaired locomotion, there is always the danger of a fall. Consequently, a caregiver is required, and the effect of the training is cut by half because the patient's anxiety about falling is exacerbated. Slow stepping affords strengthening and balance training of the leg muscles for patients whose walking ability has become low, and walking ability is improved. However,whether such training appropriately carries out stepping and the degree of the effect of such training has not been evaluated. Therefore, we have developed a stepping measturement device that monitors stepping for evaluation and training of walking ability. This system consists of two mat switches for stepping, a measuring circuit for stepping detection, and a book-sized personal computer with a PC card-type AD converter. This system can detect a left or right single stance phase and a double stance phase relative to the ON, OFF condition of the mat switch. After measurement, the following items are analyzed and displayed : ・number of steps, ・average time of double stance phase, ・the average time of single stance phase, and so on. Finally, we measured the stepping of subjects whose walking ability is low, and showed the relationship between daily walking conditions and stepping conditions. The effectiveness of this system was considered in light of the results. kn-abstract=急性膵炎の回復後その発症原因の検索において発見された小膵癌の3例を報告し，膵炎の発症原因の一つとして膵癌を常に念頭におく必要があることを強調した。またスクリーニング検査および精査において小膵癌を診断する手順について考察を加えた。症例1は初回発作の回復後に，症例2および症例3は再発発作の回復後に急性膵炎の発症原因の検索を目的に紹介された。いずれの症例においても血清腫瘍マーカーは正常植を示し，腹部USおよびCTは腫瘍から尾側の膵管の拡張を示したが腫瘍そのものは描出はできなかった。症例1ではERCP像から膵体部癌を強く疑い，症例2と症例3ではERCP像と細胞診陽性所見から膵頭部癌と確診し，手術を行った。腫瘍の最大径は症例1では0.9cm，症例2では1.5cm，症例3では2.0cmであり，いずれも転移を認めず根治切除可能であった。 en-copyright= kn-copyright= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=3 ORCID= en-aut-name=TachibanaHideo en-aut-sei=Tachibana en-aut-mei=Hideo kn-aut-name=立花英夫 kn-aut-sei=立花 kn-aut-mei=英夫 aut-affil-num=4 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= en-aut-name=TsuboiKeiichi en-aut-sei=Tsuboi en-aut-mei=Keiichi kn-aut-name=壷井圭一 kn-aut-sei=壷井 kn-aut-mei=圭一 aut-affil-num=7 ORCID= en-aut-name=MiyakeHirofumi en-aut-sei=Miyake en-aut-mei=Hirofumi kn-aut-name=三宅啓文 kn-aut-sei=三宅 kn-aut-mei=啓文 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=小膵癌 (Small pancreatic cancer) kn-keyword=小膵癌 (Small pancreatic cancer) en-keyword=膵癌の早期発見 (Early diagnosis of pancreatic cancer) kn-keyword=膵癌の早期発見 (Early diagnosis of pancreatic cancer) en-keyword=急性膵炎 (Acute pancreatitis) kn-keyword=急性膵炎 (Acute pancreatitis) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=143 end-page=145 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Acivities of the nursing division 1989 kn-title=看護部活動報告 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三朝分院看護部 kn-aut-sei=三朝分院看護部 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=168 end-page=183 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Publications and lectures in 1989 kn-title=業績集 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=61 end-page=67 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical evaluation of new formula included oligopetide as a nitrogen source in surgical patients kn-title=オリゴペプチド経腸栄養剤の使用経験 en-subtitle= kn-subtitle= en-abstract=The clinical usefulness of new enteral formula which is contained di-and tri-peptides as a nitrogen source was evaluated in surgical patients. The enteral nutrition was introduced to stable patients who could not take food orally and postoperative ones who were undertaken upper GI surgery. Adverse effects such as diarrhea or abdomonal distension were not observed. V isceral proteins were improved after administration of this regimen and nutritional status was maintained in all patients. However, high urinary excretion of 3methylhistidine continued in great extent during postopertive period and breakdown of skeletal muscle was not prevented by this nutritional therapy. This might be due to insufficient intake of energy and nitrogen. This new product for enteral nutrition would be safe and useful as enteral nutrition. kn-abstract=窒素源としてdi-，tri－peptideを含有した経腸栄養剤を外科患者に使用した。．この新しい経腸栄養剤は卵白を加水分解したもので，70％がoligopeptideであり，アミノ酸も10％含まれる。糖質はデキストリンで，脂肪の含有量は少なく浸透圧はエレメンタルダイエット（ED）より低い。この製剤を安定期および術後に使用した。アルブミン，rapid turnover proteinの回復がみられ，臓器蛋白の合成が得られた。術後例では3メチルヒスチジンの排泄量は減少せず，異化反応は抑制されなかった。投与量の不足が一つの原因と思われる。副作用の下痢はほとんどみられず，栄養改善効果もあり，有用性が認められた。 en-copyright= kn-copyright= en-aut-name=SodaMitsuhiro en-aut-sei=Soda en-aut-mei=Mitsuhiro kn-aut-name=曽田益弘 kn-aut-sei=曽田 kn-aut-mei=益弘 aut-affil-num=1 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=2 ORCID= en-aut-name=MorisueSinhachi en-aut-sei=Morisue en-aut-mei=Sinhachi kn-aut-name=森末真八 kn-aut-sei=森末 kn-aut-mei=真八 aut-affil-num=3 ORCID= en-aut-name=HiraiShunichi en-aut-sei=Hirai en-aut-mei=Shunichi kn-aut-name=平井俊一 kn-aut-sei=平井 kn-aut-mei=俊一 aut-affil-num=4 ORCID= en-aut-name=Suzukalchio en-aut-sei=Suzuka en-aut-mei=lchio kn-aut-name=鈴鹿伊智雄 kn-aut-sei=鈴鹿 kn-aut-mei=伊智雄 aut-affil-num=5 ORCID= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=6 ORCID= en-aut-name=KajitaniNobuaki en-aut-sei=Kajitani en-aut-mei=Nobuaki kn-aut-name=梶谷伸顕 kn-aut-sei=梶谷 kn-aut-mei=伸顕 aut-affil-num=7 ORCID= en-aut-name=YoshizaneKen en-aut-sei=Yoshizane en-aut-mei=Ken kn-aut-name=吉實憲 kn-aut-sei=吉實 kn-aut-mei=憲 aut-affil-num=8 ORCID= en-aut-name=NaniwaHiroyuki en-aut-sei=Naniwa en-aut-mei=Hiroyuki kn-aut-name=浪花宏幸 kn-aut-sei=浪花 kn-aut-mei=宏幸 aut-affil-num=9 ORCID= en-aut-name=TeramotoShigeru en-aut-sei=Teramoto en-aut-mei=Shigeru kn-aut-name=寺本滋 kn-aut-sei=寺本 kn-aut-mei=滋 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二外科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二外科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第二外科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院第二外科 en-keyword=経腸栄養 (Enteral nutrition) kn-keyword=経腸栄養 (Enteral nutrition) en-keyword=エレメンタルダイエット (Elemental diet) kn-keyword=エレメンタルダイエット (Elemental diet) en-keyword=オリゴペプチド (Oligopeptide) kn-keyword=オリゴペプチド (Oligopeptide) en-keyword=外科栄養 (Surgical nutrition) kn-keyword=外科栄養 (Surgical nutrition) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=68 end-page=72 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=日本に於ける二酸化炭素泉療法の現況 kn-title=CO(2) Balneotherapy in Japan en-subtitle= kn-subtitle= en-abstract=日本では，天然の二酸化炭素泉は殆ど利用されていない。一方，CO(2)錠剤，CO(2)給水装置が開発されて人工二酸化炭素泉がよく用いられるようになってきた。皮下組織の酸素分圧の上昇と組織循環の改善という好ましい生理作用により，結合織の退行性変化による慢性障害，すなわち強皮症，関節症，慢性関節痛，腰痛症，および末梢循環障害に伴う組織の栄養障害に適応がある。また，疲労回復を促進し，いわゆる冷え症に好ましく作用する。 kn-abstract=Natural CO(2) springs have been scarcely utilized in Japan, whereas artificial CO(2) bathing has become popular by the introduction of CO(2) tablets and other apparatus for CO(2) water supply. Artificial CO(2) bathing is indicated for degenerative connective tissue disorders such as scleroderma, common stiff and painful shoulders, chronic joint pain, lumbago, and trophic changes due to insufficient peripheral circulation by virtue of the increase of tissue pO(2) and the improvement of tissue perfusion. Artificial CO(2) bathing promotes recovery from fatigue and is beneficial in women whose health has been adversely affected by cold. en-copyright= kn-copyright= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=1 ORCID= en-aut-name=SodaMitsuhiro en-aut-sei=Soda en-aut-mei=Mitsuhiro kn-aut-name=曽田益弘 kn-aut-sei=曽田 kn-aut-mei=益弘 aut-affil-num=2 ORCID= en-aut-name=HiraiShunichi en-aut-sei=Hirai en-aut-mei=Shunichi kn-aut-name=平井俊一 kn-aut-sei=平井 kn-aut-mei=俊一 aut-affil-num=3 ORCID= en-aut-name=MorisueShinhachi en-aut-sei=Morisue en-aut-mei=Shinhachi kn-aut-name=森末真八 kn-aut-sei=森末 kn-aut-mei=真八 aut-affil-num=4 ORCID= en-aut-name=SuzukaIchio en-aut-sei=Suzuka en-aut-mei=Ichio kn-aut-name=鈴鹿伊智雄 kn-aut-sei=鈴鹿 kn-aut-mei=伊智雄 aut-affil-num=5 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設 en-keyword=CO(2) -balneotherapy kn-keyword=CO(2) -balneotherapy en-keyword=Artificial CO(2) -bathing kn-keyword=Artificial CO(2) -bathing en-keyword=Tissue pO(2) kn-keyword=Tissue pO(2) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=98 end-page=113 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=New trend of the development of vascular prostheses kn-title=人工血管開発における研究の動向 en-subtitle= kn-subtitle= en-abstract=Vascular prostheses have been used in the treatments of various vascular diseases. We expect much from their contribution in the field of further fine vascular surgery. In this communication, new trend of the development of them with our new ideas in our recent research works were described. 1. Healing process of fabric vascular prostheses. Neointima formation of the vascular prosthesis implanted in the descending thoracic aortae of experimental animals were described in detail. This showed a standard behaviour of various cells which contributed the construction of a new arterial wall. 2. Problems of vascular prostheses which were used in clinic. Several problems such as a bleeding from the graft wall, aneurysmal dilatation, and degenerative changes of the neointimae were explained in detail. These problems were related with the structure of each vascular prosthesis. 3. Vascular prostheses developing with new ideas. Several vascular prostheses developing today were described as follows. (a) Fabric prosthesis with high healing ability. A prosthesis made of ultra-fine polyester fibers which can accerelate cell migration and proliferation inside the prosthetic wall was introduced. The neointima in this prosthesis was constructed very rapidly compared with that of the prostheses made of polyester fiber ordinally used. (b) Antithrombogenic small diameter vascular prostheses. Large caliber vascular prostheses have been used very safely in clinic, however, small diameter ones were seldom used due to its low patency rate by their occlusion. The grafts should have an antithrombogenic property to prevent the thrombus formation. Recently, some technologies to give antithrombogenic property to the vascular prostheses were developed. They were a heparin slow release technique, antithrombogenic segmented polyurethane, highly hydrous surface, heparinized collagen tube, etc. They were applied for the development of small diameter vascular grafts and showed good results in some animal experiments. (c) Growable vascular graft. A vascular graft which can grow with the growth of its recipient baby was demonstrated. The animal study showed as expected growth and stop growing at the expected time. (d) Vascular graft for aorto-coronary bypass surgery. A small diameter antithrombogenic, and flexible vascular grafts were explained. They were developed along our own ideas. This showed high patency rate m animal experiments. (e)Endothelial cell seeding techniques. In human, endothelialization m the vascular grafts is delayed and the inner surface was thrombogenic for a long period of time. To accerelate the endothelialization, cell seeding technique have been investigated in the last decade. We developed a new technology to transplant autologous cells in the peripheral vein tissue for this purpose. This was very reliable and simple. It was applicable in any hospital without any special technique and facility. Peripheral venous tissue fragments were transplanted into the fabric vascular prosthetic wall. Endothelial cells and smooth muscle cells migrated and proliferated from the tissue fragments. The neointima was constructed very rapidly with this active cell migrations. kn-abstract=人工血管の開発研究における動向について，我々の行ってきた研究をまじえて世界の動きを解析した。近年の砺究の流れは過去1世紀にわたる試行錯誤の上にあって，さらに大きく揺れ動いている。人工血管の内面に必要な抗血栓性の獲得においても，設計者によって考えを異にし，米国では，人工心臓に用いる抗血栓性合性高分子材料をもってそれに当てようとしているものが多い。我々はあくまで宿主のもつ諸機能を引き出し，自然の動きの一つとしての治癒を無理なく導いて，内皮細胞によって内面を覆わせる方法を採用している。そのいくつかの例として，超極細ポリエステル繊維製人工血管，結合組織管，バイオマトリックス人工血管，ヘパリン化生体組織由来人工血管，成長できる人工血管などについて解説した。 en-copyright= kn-copyright= en-aut-name=NoishikiYasuharu en-aut-sei=Noishiki en-aut-mei=Yasuharu kn-aut-name=野一色泰晴 kn-aut-sei=野一色 kn-aut-mei=泰晴 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 en-keyword=人工血管 (Vascular prosthesis) kn-keyword=人工血管 (Vascular prosthesis) en-keyword=新生内膜 (Neointima) kn-keyword=新生内膜 (Neointima) en-keyword=内皮細胞 (Endothelial cells) kn-keyword=内皮細胞 (Endothelial cells) en-keyword=抗血栓性 (Antithrombogenicity) kn-keyword=抗血栓性 (Antithrombogenicity) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=89 end-page=97 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical significance of eosinophilic leucocytes in onset mechanisms of bronchial asthma kn-title=気管支喘息の発症病態における好酸球の臨床的意義 en-subtitle= kn-subtitle= en-abstract=Participation of eosinophil leucocytes in onset mechanisms of bronchial asthma was discussed in following sections ; 1. changes in number of eosinophils in the peripheral blood, 2. emergence of eosinophils in local allergic reaction sites, 3. eosinophils and allergic reactions, 4. different functions of eosinophils III allergic reactions, 5. eosinophils and clinical types of bronchial asthma. The results showed that eosinophilia in the peripheral blood was generally observed in patients with bronchial asthma. In these cases, eosinophils migrated into local allergic reaction sites. A reversed correlation was present between number of eosinophils and macrophages, and number of eosinophils correlated to a certain extent with number of lymphocytes in the small airways and alveolar region. Function of eosinophils was shown to be different between IgE-and non-IgE-mediated reactions, by measurement of arylsulfatase activity III BALF. Marked eosinophilia in BALF was observed in any clinical types of atopic asthma, although eosinophils were increased only in bronchoconstriction + hypersecretion type (type II) of non-atopic asthma. kn-abstract=末梢血好酸球が気管支喘息の発症病態にどのように関与しているかについて，1．末梢血好酸球の変動，2．好酸球の局所出現，3，好酸球とアレルギー反応，4．アレルギー反応と好酸球の機能，5．好酸球と喘息の臨床病態の各項目で検討した。その結果，気管支喘息では，全般的に末梢血好酸球増多がみられ，同時にアレルギー反応局所への遊走が観察されること，末梢気 道では，ある程度肺胞マクロファージの出現と逆相関にあること，リンパ球との関連もある程度認められることなどが示された。そして，局所出現した好酸球は，IgE抗体の関与の程度により，その機能が異なる可能性が示唆された。また臨床病型別の検討では，アトピー型ではいずれの臨床山型においても好酸球の出現率は明かな増加傾向を示したが，非アトピー型では，Ib．気管支攣縮＋過分二型においてのみ好酸球増多が著明であった。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=4 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=5 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=6 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=7 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=好酸球 (Eosinophils) kn-keyword=好酸球 (Eosinophils) en-keyword=肺生検 (Lung biopsy) kn-keyword=肺生検 (Lung biopsy) en-keyword=気管支肺胞洗浄 (Bronchoalveolar lavage) kn-keyword=気管支肺胞洗浄 (Bronchoalveolar lavage) en-keyword=臨床病型 (Clinical type) kn-keyword=臨床病型 (Clinical type) en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=114 end-page=122 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Hyhrid vascular grafts and one of our approaches kn-title=人工血管のハイブリット化 en-subtitle= kn-subtitle= en-abstract=Recently, vascular grafts had contributed in the treatments of various vascular disease, and today, was required to have fine functions like native blood vessels. Many kinds of approaches to develop the ideal graft had been applied. In these efforts, endothelial cells seeding technique to fabric vascular prostheses was reported successfully, however, it was not for general use. To get and proliferate the endothelial cells, special techniques and facilities were required. Moreover, it was not available for emergency use, smce the cell culture needed a certain period of time. To overcome these problems, we developed a reliable method to make a hybrid vascular graft as follows. Tissue fragments suspension was prepared using a piece of peripheral vein. Highly porous fabric vascular prosthesis was immersed into the suspension fluid. The tissue fragments were trapped from the outer surface of the prosthesis by intraluminal suction. Preclotting procedure was adopted to immobilize the tissue fragments to the fabric of the prosthesis. The prostheses were implanted into the thoracic descending aortae of 15 dogs. There was no bleeding at the time of the implantation. Numerous endothelial cells proliferation was observed in the specimen for 5 days after implantation. The surface was covered with thin layer of fibrin. Full endothelialization was noticed in the specimens of 35 days. The graft wall was completely healed. This method was very simple and easy to prepare, but the efficacy to promote the healing of the neointima was excellent. kn-abstract=人工血管により高度な機能をもたす目的で，ハイブリット化が今日進められるようになってきた。この背景について説明するとともに，我々の独自に行っているハイブリット型人工血管作成の方法およびその成果について報告する。その具体的方法としては以下の通りである。末梢静脈小片を勇刀にて細切したのち，約20ccの生理的食塩水に入れて静脈組織細切片浮遊液を作った。次に高有孔性人工血管の一端より吸引管を挿入し，これを作成した液に入れ，吸引によって組織片を外側から人工血管壁に絡ませた。次に新鮮な血液を注ぎ，組織片をさらに固着させた。成犬胸部下行大動脈へこのような処理をしたポリエステル布製人工血管を植え込んだところ，植え込み5日目に新生血管壁内部に無数の内皮細胞の増殖像がみられ，35日目の例では吻合部はもとより，人工血管の中央部ですら内皮細胞による完全な被覆を認めた。 　以上のような方法で新生血管壁が容易に形成されることが判明したことより，今後，他の人工臓器分野でもハイブリット化が予測される。 en-copyright= kn-copyright= en-aut-name=NoishikiYasuharu en-aut-sei=Noishiki en-aut-mei=Yasuharu kn-aut-name=野一色泰晴 kn-aut-sei=野一色 kn-aut-mei=泰晴 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 en-keyword=人工血管 (Vascular graft) kn-keyword=人工血管 (Vascular graft) en-keyword=ハイブリット (Hybrid) kn-keyword=ハイブリット (Hybrid) en-keyword=新生内膜 (Neointima) kn-keyword=新生内膜 (Neointima) en-keyword=内皮細胞 (Endothelial cell) kn-keyword=内皮細胞 (Endothelial cell) en-keyword=自家移植 (Autologous transplantation) kn-keyword=自家移植 (Autologous transplantation) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=55 end-page=60 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Antithrombogenic therapy after heart valve replacement - Effect of anti-platelet drug on aggregation- kn-title=人工弁置換後の抗凝血療法 ―血小板凝集抑制剤の効果― en-subtitle= kn-subtitle= en-abstract=To evaluate the effect of anti-thrombotic thrapy after valve replacement, serial platelet aggregation measurememnts were carried out in 103 patients. Patients were divided into three groups. e. i. warfarin alone (control), warfarin with trapidil (TP) of 300mg/day and dipyridamole (DP) of 300mg/day. The aggregation of platelet of the control group did not change through 36 months. TP group showed a decrease in platelet aggregation at 24 and 30 months from the pretreatment value. The aggregation of 24 month in TP was significantly lower than that of control. There was no difference of platelet aggregation between TP and DP group. The incidence of thromboembolism of control, TP and DP group were 9.5%, 4.3% and 7.7%, respectively. These data suggest that the supression of platelet aggregation .by TP and DP is not adequate to continue for long time and TP has similar anti-thrombotic effect to DP. kn-abstract=人工弁置換患者の血栓塞栓症（TE）は，長期予後の成績を左右する。　TEを減少させるために凝固因子を抑制するwarfarinと抗血小板剤による抗血栓療法が行われている。人工弁置換患者103例を対象に，抗血小板剤であるtrapidil（TP）とdipyridamole（DP）の血小板凝集能に与える効果を検討した。36ヵ月間検討したが，warfarin単独群は血小板凝集能に変化がなく，TP，DP共にADP凝集能を抑制した。しかし有意差の見られたのは全経過ではなく，凝集能抑制は強力かつ持続的ではなかった。またコラーゲン誘導凝集能は変化を認めなかった。TPとDPの抗血小板効果は同等と思われる。期間中の血栓塞栓発生は，warfarin単独群9.5％，TP群4.3％，DP群7.7％であった。臨床的に抗血小板剤の併用は有効と思われるが，血小板凝集抑制には投与量の増量，あるいは他の薬剤の検討が必要であろう。 en-copyright= kn-copyright= en-aut-name=SodaMitsuhiro en-aut-sei=Soda en-aut-mei=Mitsuhiro kn-aut-name=曽田益弘 kn-aut-sei=曽田 kn-aut-mei=益弘 aut-affil-num=1 ORCID= en-aut-name=YorozuHidenori en-aut-sei=Yorozu en-aut-mei=Hidenori kn-aut-name=萬秀憲 kn-aut-sei=萬 kn-aut-mei=秀憲 aut-affil-num=2 ORCID= en-aut-name=SuzukaIchio en-aut-sei=Suzuka en-aut-mei=Ichio kn-aut-name=鈴鹿伊智雄 kn-aut-sei=鈴鹿 kn-aut-mei=伊智雄 aut-affil-num=3 ORCID= en-aut-name=MorisueShinhachi en-aut-sei=Morisue en-aut-mei=Shinhachi kn-aut-name=森末真八 kn-aut-sei=森末 kn-aut-mei=真八 aut-affil-num=4 ORCID= en-aut-name=HiraiShunnichi en-aut-sei=Hirai en-aut-mei=Shunnichi kn-aut-name=平井俊一 kn-aut-sei=平井 kn-aut-mei=俊一 aut-affil-num=5 ORCID= en-aut-name=KomotoYoshiaki en-aut-sei=Komoto en-aut-mei=Yoshiaki kn-aut-name=古元嘉昭 kn-aut-sei=古元 kn-aut-mei=嘉昭 aut-affil-num=6 ORCID= en-aut-name=KajitaniNobuaki en-aut-sei=Kajitani en-aut-mei=Nobuaki kn-aut-name=梶谷伸顕 kn-aut-sei=梶谷 kn-aut-mei=伸顕 aut-affil-num=7 ORCID= en-aut-name=YoshizaneKen en-aut-sei=Yoshizane en-aut-mei=Ken kn-aut-name=吉實憲 kn-aut-sei=吉實 kn-aut-mei=憲 aut-affil-num=8 ORCID= en-aut-name=NaniwaHiroyuki en-aut-sei=Naniwa en-aut-mei=Hiroyuki kn-aut-name=浪花宏幸 kn-aut-sei=浪花 kn-aut-mei=宏幸 aut-affil-num=9 ORCID= en-aut-name=KojoMasayoshi en-aut-sei=Kojo en-aut-mei=Masayoshi kn-aut-name=古城昌義 kn-aut-sei=古城 kn-aut-mei=昌義 aut-affil-num=10 ORCID= en-aut-name=TeramotoShigeru en-aut-sei=Teramoto en-aut-mei=Shigeru kn-aut-name=寺本滋 kn-aut-sei=寺本 kn-aut-mei=滋 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設リハビリテーション外科学分野 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二外科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二外科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第二外科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院第二外科 affil-num=11 en-affil= kn-affil=岡山大学医学部附属病院第二外科 en-keyword=人工弁置換術 (Heart valve replacement) kn-keyword=人工弁置換術 (Heart valve replacement) en-keyword=血栓塞栓症 (Thromboembolism) kn-keyword=血栓塞栓症 (Thromboembolism) en-keyword=血小板凝集 (Platelet aggregation) kn-keyword=血小板凝集 (Platelet aggregation) en-keyword=抗血小板剤 (Anti-thrombotic drug) kn-keyword=抗血小板剤 (Anti-thrombotic drug) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=46 end-page=54 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Thermological study on the coldness in women kn-title=サーモグラフィによる冷え症の病態生理学的検討 en-subtitle= kn-subtitle= en-abstract=Whole body surface temparature was measured in 41 women with a thermtracer 6T66. Except palm, sole and instep, there were no differences in surface temperature of other parts of the body among these cases. Surface temperature of palm, sole and instep were lower than other parts of the body and showed 4 characteristic distribution patterns on thermography. Thermography at palm, sole and instep is useful for the objective approach of the patients who complain of coldness in some part of their bodies. kn-abstract=サーモグラフィを用いた冷え症の診断基準を作ることを目的として，冷え症患者（30名）の体表面温度分布を体表面を11カ所に分けて中間温環境下でサーモトレーサ6T66を1用いて測定し，対称群（11名）と比較した。同時にCMI調査と，患者の日常生活に関するアンケート調査を実施した。その結果1．冷え症群では四肢末端部，ことに手掌・足背・足底において最低温度が低く，局所の最高・最低温度間の温度較差が大きい傾向を示した。軀幹部では最高温度，最低温度，温度較差すべて両群間に大きな差はみられなかった。2．冷え症群の手掌，足背，足底の温度分布パターンは末端部ほど温度が低いという特徴的なパターンを多く示した。3．CMI調査では，冷え症群の中等症と軽症例の一部に強い神経症的傾向を認めたが，重症例では神経症的傾向は軽度であった。4．アンケート調査では脂っこいものよりあっさりしたものを好きであるとか，顔にのぼせを感じることがある，甘いものが好きであるという例が冷え症群に多かった。以上の結果からサーモグラフィを用いて中間温環境下で四肢末端の温度鈴布を測定することにより，冷え症を客観的に診断する可能性を得た。 en-copyright= kn-copyright= en-aut-name=TakatoriAkimasa en-aut-sei=Takatori en-aut-mei=Akimasa kn-aut-name=高取明正 kn-aut-sei=高取 kn-aut-mei=明正 aut-affil-num=1 ORCID= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=2 ORCID= en-aut-name=SekibaKaoru en-aut-sei=Sekiba en-aut-mei=Kaoru kn-aut-name=関場香 kn-aut-sei=関場 kn-aut-mei=香 aut-affil-num=3 ORCID= en-aut-name=TanizakiYosiro en-aut-sei=Tanizaki en-aut-mei=Yosiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部産科婦人科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=婦人の冷え症 (Coidness in women) kn-keyword=婦人の冷え症 (Coidness in women) en-keyword=サーモグラフィ (Thermography) kn-keyword=サーモグラフィ (Thermography) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=79 end-page=88 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diabetic complications in the advanced stage of chronic pancreatitis. kn-title=膵性糖尿病の合併症 en-subtitle= kn-subtitle= en-abstract=Exocrine dysfunction (maldigestion) and endocrine dysfunction (diabetes) are malll clinical features in the advanced stage of chronic pancreatitis. Diabetic complications were previously considered to be infrequent in diabetes secondary to chronic pancreatitis (pancreatic diabetes). However, the recent improvement in life expectancy and closer observation of the clinical course of patients with chronic pancreatitis have revealed that diabetic complications are not infrequent in pancreatic diabetes as compared with primary diabetes mellitus and that diabetes is one of the most important prognostic factors in chronic pancreatitis. We, therefore, reviewed recent articles on the topics before beginning a national survey of diabetic complications in patients with pancreatic diabetes. It has been suggested that : (1) diabetic microangiopathy (retinopathy, nephropathy and peripheral neuropathy) is almost as frequent in secondary diabetes as in primary diabetes, although the severity is less in secodary diabetes : (2) peripheral neuropathy is frequent in alcoholic chronic pancreatitis : (3)macroangiopathy (myocardial infarction, cerebral thrombosis, atherosclerosis) is less frequent in pancreatic diabetes. We also discussed various factors which may precipitate the diabetic complications. kn-abstract=慢性膵炎が進行すると膵内外分泌不全に対する治療が主体となる。かつては膵疾患に由来する糖尿病（膵性糖尿病）においては糖尿病性合併症の発症が少ないとされていたが，慢性膵炎の長期経過観察例の増加とともにその頻度が一次性糖尿病にくらべて必ずしも低くないことが指摘されるようになった。そこで今回，厚生省難治性膵疾患調査研究班「慢性膵炎の新しい治療法の開発」小委員会の研究活動の一環として膵性糖尿病の治療法を再検討することになったのを機会に，その手始めに野性糖尿病の合併症に関する従来の報告を整理した。その結果，一次性糖尿病の場合にくらべて，細小血管症（網膜症，腎症，神経障害）はほぼ同程度であるが軽症例が多いこと，大血管症（心筋梗塞，脳硬塞，動脈硬化症）は少ないことが示唆された。そのほか，膵性糖尿病の合併症の発症に関与すると考えられる諸因子についても概説した。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=TachibanaHideo en-aut-sei=Tachibana en-aut-mei=Hideo kn-aut-name=立花英夫 kn-aut-sei=立花 kn-aut-mei=英夫 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=膵性糖尿病 (Pancreatic diabetes) kn-keyword=膵性糖尿病 (Pancreatic diabetes) en-keyword=慢性膵炎 (Chronic pancreatitis) kn-keyword=慢性膵炎 (Chronic pancreatitis) en-keyword=合併症 (Complications) kn-keyword=合併症 (Complications) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=36 end-page=40 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical study on polypoid lesions of the colon kn-title=大腸ポリープの臨床的検討 en-subtitle= kn-subtitle= en-abstract=This report is concerned with clinical study on 90 patients with polypoid lesions (107 lesions) which we have encountered in Misasa Hospital, Okayama University in the past 4 years. Following results were obtained : (1) Polypoid lesions were detected in 90 (22.4%) and advanced adenocarcinoma (mostly resectable) in 22 (5.5%) of 402 patients who were examined by sigmoidoscopy and barium enema ; (2) Histological examination of the polypoid lesions showed adenoma in 77.2%, hyperplastic polyp in 8.7%, inflammatory polyp in 7.6%, neurinoma in 0.3% and early cancer (adenocarcinoma) in 5.4% ; (3) It was impossible to differentiate benign and malignant polypoid lesions on the basis of endoscopic and X-ray findings alone ; (4) Forty-two percent of the polypoid lesions was detected in the sigmoid colon, 30% in the rectum, 16.8% in the descending colon, 9.3% in the ascending colon, 0.9% in the caecum ; (4) Patients younger than 50 years of age showed only one polypoid lesion in the right hemicolon, whereas elder patients showed as many as 17 polypoid lesions ; (5) Among the 90 patients with polypoid lesions, 40 presented with abdominal pain, 20 with no symptoms (annual health check-up), 17 with irregular bowel habits, and 10 with melena ; (6) Among the 90 patients, occult blood in stool was positive in 75.8% with a lower positive rate in the lesions of the sigmoid and rectum ; (7) Among 5 asymptomatic patients with lesions and with a negative hemoccult test, 3 patients with a polypoid lesion were examined because of the patients' request, 1 patient with a polypoid lesion because of a positive family history, and the remaining 1 patient in a search for the primary lesion of the metastatic liver cancer ; (8) Among patients with a positive hemoccult test, the detection rate of polypoid lesions was 41.9% with use of an immunological method, whereas it was 19.7% with use of a chemical method. In conclusion, (1) detection of colonic polypoid lesions can lead to the detection of early cancer, although only histological examination can confirm the accurate diagnosis ; (2) a hemoccult test in stool with an immunological method is an effective method for screening asymptomatic colonic polypoid lesions, although it must be admitted that negative results may occasionally occur ; (3) macroscopic observation of the stool mass is important before sampling, because lesions of the sigmoid colon or the rectum may show scanty blood only on the limited area of the surface of the stool ; (4) patients elder than 50 years of age should be examined more carefully for the whole colon preferably with an endoscope, because they show a high incidence of small polypoid lesions in the right hemicolon. kn-abstract=1986年4月から1990年2月末までの間に岡山大学医学部附属病院三朝分院で経験した早期大腸癌を含む大腸ポリープ90例（107病変）を対象に，年齢，臨床症状，便潜血反応，病変存在部位について検討を行い，以下の成績を得た。(1)大腸検査総数の22.4％にポリープが発見された。ポリープの77％は腺腫，5％は腺癌（早期癌）であった。(2)便潜血反応はポリープ例の75.9％に陽性であり，右側大腸ポリープでの陽性率は高かったが，S状結腸および直腸ポリープでは70％程度であった。(3)若年者では右側結腸にポリープが発見されることは稀であるが，50才以上では18％程度に認められた。高齢者では右側結腸も内視鏡で検査することが重要である。(4)免疫学的便潜血検査法の導入により大腸ポリープの発見効率が改善するものと考え られた。 en-copyright= kn-copyright= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=5 ORCID= en-aut-name=TachibanaHideo en-aut-sei=Tachibana en-aut-mei=Hideo kn-aut-name=立花英夫 kn-aut-sei=立花 kn-aut-mei=英夫 aut-affil-num=6 ORCID= en-aut-name=AkiyamaTsuneo en-aut-sei=Akiyama en-aut-mei=Tsuneo kn-aut-name=穐山恒雄 kn-aut-sei=穐山 kn-aut-mei=恒雄 aut-affil-num=7 ORCID= en-aut-name=NakaiMutsuo en-aut-sei=Nakai en-aut-mei=Mutsuo kn-aut-name=中井睦郎 kn-aut-sei=中井 kn-aut-mei=睦郎 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属品境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属品境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属品境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属品境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属品境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学附属病院三朝分院放射線科 affil-num=8 en-affil= kn-affil=岡山大学附属病院三朝分院放射線科 en-keyword=大腸ポリープ (Polyp of the colon) kn-keyword=大腸ポリープ (Polyp of the colon) en-keyword=大腸早期癌 (Early cancer of the colon) kn-keyword=大腸早期癌 (Early cancer of the colon) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=41 end-page=45 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Maternity swimming at Misasa Hospital of Okayama University Medical School. -Third report. The physiological changes before and after the maternity swimming- kn-title=岡山大学医学部三朝分院における妊婦水泳 ―第三報，妊婦水泳が母児の循環器系に与える影響について― en-subtitle= kn-subtitle= en-abstract=The physiological changes before and after the maternity swimming were retrospectivelly analyzed in 151 records. Following findings were observed after maternity swimming: 1. An increase in maternal pulse rate was observed in 116 cases (76.8%) out of all the cases. 2. Maternal blood pressure increased in 81 cases (53.6%) and decreased in 60 cases (39.7%). 3. An Increase In baseline of fetal heart rate was found in 92 cases (60.9%). 4. Long term variability (LTV) decreased in 67 case s (44.3%) and increased in 21 cases (13.9%). 5. The number of cases with increased fetal movement was almost similar to the number of cases with decreased movement. 6. The rate of uterine contraction increased in 66 cases (43.7%), but there were no cases to need any treatment. The conclusion was as follows: 1. No dangerous changes were observed in non stress test (NST), maternal pulse rate and maternal blood pressure. 2. The increase of baseline of fetal heart rate and the decrease of LTV were characteristic changes of NST after the maternity swimming. kn-abstract=第一報において妊婦水泳に関する妊婦の認識について報告し，第二報において妊婦水泳の現状とその適応について報告したが，その後も症例は順調に増加しており，現在までの参加人数は49名に達した。今回は妊婦水泳が母体と胎児の循環器系にどのような影響を与えるかを調べるために，妊婦水泳の前後におけるnon stress test（NST）と母体の血圧と脈拍数の変化を分析した。対象は妊娠5カ月以降の21名の正常妊婦とした。1．母体の脈拍数は水泳後に増加するものが約80％と明らかに多かったが，血圧は水泳前後で大きな差はみられなかった。2．NSTでは，水泳後に胎児基準心拍数の増加するものが妊娠中期で55.2％，後期で62.3％と多かった。胎児心拍数のlong term variability（LTV）は水泳後に減少するものが妊娠後期で 48.4％を占めた。3.胎動回数は水泳前後でほぼ一定であった。腹緊回数が水泳後に増加した例が妊娠後期で42.4％を占めた。これらの結果のうち，水泳後の胎児基準心拍数の増加とLTVの減少について生理学的見地より若干の考察を加えた。 en-copyright= kn-copyright= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=1 ORCID= en-aut-name=TakatoriAkimasa en-aut-sei=Takatori en-aut-mei=Akimasa kn-aut-name=高取明正 kn-aut-sei=高取 kn-aut-mei=明正 aut-affil-num=2 ORCID= en-aut-name=KondouYuuji en-aut-sei=Kondou en-aut-mei=Yuuji kn-aut-name=近藤裕司 kn-aut-sei=近藤 kn-aut-mei=裕司 aut-affil-num=3 ORCID= en-aut-name=SakataJunnko en-aut-sei=Sakata en-aut-mei=Junnko kn-aut-name=坂田旬子 kn-aut-sei=坂田 kn-aut-mei=旬子 aut-affil-num=4 ORCID= en-aut-name=YoshidaSachie en-aut-sei=Yoshida en-aut-mei=Sachie kn-aut-name=吉田佐智江 kn-aut-sei=吉田 kn-aut-mei=佐智江 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=妊婦水泳 (Maternity swimming) kn-keyword=妊婦水泳 (Maternity swimming) en-keyword=胎児心拍数 (Fetal heart rate) kn-keyword=胎児心拍数 (Fetal heart rate) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=73 end-page=78 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Re-evaluation of spa-drink therapy for digestive diseases kn-title=消化器疾患における飲泉療法の再評価 en-subtitle= kn-subtitle= en-abstract=With the advent of new instruments for examining the digestive organs, we have attempted to re-evaluate the efficacy and indications of spa-drink therapy for digestive diseases. This report deals with an overview of the results we have obtained so far. Effect of oral intake of thermal water (Misasa thermal water, 38-42℃, 150-200 ml) on gastric mucosal blood flow was evaluated, using an endoscopic organ reflex spectrophotometry together along with an Olympus XQ - 10 forward viewing gastrofiberscope. Single intake of thermal water as well as long-term spa-drink therapy (two times a day between meals for more than two weeks) brought about an improvement of gastric mucosal blood flow. Gastric emptying function was evaluated with an acetaminophen method. Single intake of thermal water brought about disordered gastric emptying (excessively accelerated or suppressed). However, long-term spa-drink therapy brought about an improvement (normalization) of gastric emptying function. Exocrine pancreatic function was evaluated with a synthetic peptide, N-BT-PABA, and also by measuring fecal chymotrypsin actIvIty. Longterm spa-drink therapy brought about an improvement of exocrine pancreatic function. Motility of the gall-bladder was evaluated by abdominal ultra-sonography. Long-term spa-drink therapy gave no effect on the motility of the gallbladder. In conclusion, our recent study indicate that : (1) single oral intake of thermal water as well as longterm spa-drink therapy is effective for gastric diseases related to decreased gastric mucosal blood flow (treatment of intractable peptic ulcer and chronic gastritis, and prevention of recurrence of peptic ulcer) ; (2) long-term spa-drink therapy is effective for dyspepsia syndrome; (3) long-term spa-drink therapy is effective as a supplemental method in the treatment of exocrine pancreatic dysfunction (chronic pancreatitis) ; (4) thermal water should be taken between meals. kn-abstract=従来飲泉などの温泉治療は経験的知識にもとづいて行われる部分が多かったが，今後は科学的検査法を用いて有用性，適応疾患，適応病態，などを決定する必要がある。筆者らは，最近紹介された簡便な消化器検査法を用いて消化器疾患に対する飲泉療法の適応を再吟味しているので，これまでに得られた成績を中心に概説した。すなわち，(1)飲泉は1回でも連日の飲用でも，胃粘膜血流を改善する作用がある。(2)胃排出機能に対しては調整的効果を有する。(3)連日の飲泉は膵外分泌機能を改善する。したがって慢性の胃，膵疾患において粘膜血流障害，胃運動機能異常あるいは膵外分泌機能低下に起因する病気・病態に対しては積極的に飲泉療法を試みるべきである。温泉水の温度は40℃前後，飲泉の量は150～200ml，タイミングは食間空腹時がよい。 en-copyright= kn-copyright= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=1 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=2 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=3 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=4 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=飲泉療法 (Spa-drink therapy) kn-keyword=飲泉療法 (Spa-drink therapy) en-keyword=消化器機能 (Digestive function) kn-keyword=消化器機能 (Digestive function) en-keyword=胃粘膜血流 kn-keyword=胃粘膜血流 en-keyword=胃排出能 kn-keyword=胃排出能 en-keyword=膵外分泌 kn-keyword=膵外分泌 en-keyword=胆嚢機能 kn-keyword=胆嚢機能 END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=23 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical aspects of chronic obstructive lungdisease with small airways obstruction. -Comparison between bronchial asthma and chronic obstructive bronchiol itis- kn-title=細気管支領域に病変を有する慢性閉塞性呼吸器疾患の臨床的検討 en-subtitle= kn-subtitle= en-abstract=Subjects with bronchial asthma with bronchiolar obstruction (type II) and cases with chronic obstructive bronchiolitis (COB) were compared by clinical characteristics and ezaminations. (1) The mean age was slightly younger in cases with COB than in asthma cases. The mean age at onset was slightly younger in asthma cases than in cases with COB. (2) The cases with asthma showed positive immediate allergic reactions. However the cases with COB didnot show any positive reactions. (3) The frequency of neutro phils in BALF was significantly higher in the cases with COB than in the cases with asthma. The majority of cases with COB showed the high frequency of neutrophils more than 55% in BALF. (4) In the ventilatory function tests the values of % FVC and FEV(1.0%) were not different between the cases with asthma and the cases with COB. The values of % V(50) and % V(25) which represent small airway obstruction were slightly more decreased in cases with asthma than in the cases with COB. (5) Any abnormalities in roentgenograms of the cases with asthma were not distinctly observed, while the cases with COB showed overinflation and diffuse small round opacities. kn-abstract=細気管支に病変を有すると考えられる気管支喘息（細気管支閉塞型（II型）のアトピー型）と慢性閉塞性細気管支炎の違いについて臨床的に検討を加えた。(1)年令ではやや慢性閉塞性細気管支炎でやや低年令，発症年令では気管支喘息でやや低年令を示したが有意な差はみられなかった。(2)アレルギー学的検討では気管支喘息は明らかに1型アレルギー反応の関与が推測されたが，一方慢性閉塞性細気管支炎では1型アレルギー反応の関与はほとんどみられなかった。(3)Bronchoaiveolar lavage fluid（BALF）中出現細胞の検討では慢性閉塞性細気管支炎において気管支喘息に比べ好中球の有意の増加が観察され，出現率が55％以上の症例ではほぼ全例が慢性閉塞性細気管支炎であった。(4)換気機能による検討では％肺活量，1秒率では差は認められなかったが，気管支喘息で％V50，％V25のような細気管支の閉塞を示すパラメーターの低下傾向がやや高度であった。(5)胸部X線では気管支喘息では，X線上明らかなび四三陰影は認められず，一方慢性閉塞性細気管支炎では過膨脹所見も，び漫性情粒状陰影ともみられる症例が多く認められた。 en-copyright= kn-copyright= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=3 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=細気管支 (Bronchiole) kn-keyword=細気管支 (Bronchiole) en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=細気管支閉塞型 (Bronchiolar obstruction type) kn-keyword=細気管支閉塞型 (Bronchiolar obstruction type) en-keyword=慢性閉塞性細気管支炎 (Chronic obstructive bronchiolitis) kn-keyword=慢性閉塞性細気管支炎 (Chronic obstructive bronchiolitis) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=30 end-page=35 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=In Vitro Rooting and Multiple Buds Formation from Asparagus Lateral Buds with Ancymidol kn-title=典型的な臨床症状を呈さない肺結核症に対する気管支肺胞洗浄法（BAL）の診断学的意義 en-subtitle= kn-subtitle= en-abstract= kn-abstract=高齢者の増加やいわゆるcompromised　hostの増加により，肺結核症の臨床像が変化してきている。肺結核に典型的な臨床像を呈さず，頻回の喀疾検査にても抗酸菌を証明できなかった6症例に対し，気管支肺胞洗浄（bronchoalveolar lavage：BAL）を施行し，得られた洗浄液・吸引液の塗抹標本から抗酸菌を証明し，気管支粘膜の変化を認めた。以上の結果より，気管支型の結核症が増加してきている可能性が考えられた。気管支肺胞洗浄は，気管支型の結核症を含め，結核症の診断に有効と考えられた。 en-copyright= kn-copyright= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=1 ORCID= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=肺結核 (Pulmonary tuberculosis) kn-keyword=肺結核 (Pulmonary tuberculosis) en-keyword=気管支型結核症 (Tuberculosis of mucous membrane) kn-keyword=気管支型結核症 (Tuberculosis of mucous membrane) en-keyword=気管支肺胞洗浄法 (Bronchoalveolar lavage) kn-keyword=気管支肺胞洗浄法 (Bronchoalveolar lavage) en-keyword=抗酸菌 (Acid fast bacilli) kn-keyword=抗酸菌 (Acid fast bacilli) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ステロイド依存性重症難治性喘息に対する温泉療法の遠隔効果 kn-title=Distant effects of spa therapy on steroid-dependent intractable asthma en-subtitle= kn-subtitle= en-abstract=67例のステロイド依存性重症難治性喘息を対象に，温泉療法を行い，その即時的効果（1週間後）および遠隔効果（1年後），さらには，温泉療法後の継続療法の影響などについて検討を加えた。1．温泉療法1週間後の即時的効果は比較的高く，その有効率は，Ⅰa．気管支攣縮型で61.5％，Ⅰb．気管支攣縮＋過分泌型で82.7％，Ⅱ．細気管支閉塞型で83.4％であった。2．温泉療法の遠隔効果では，その有効率は，Ⅰa型で50.2％，Ⅰb型で54.1％，Ⅱ型で63.7％であった。3．温泉療法の遠隔効果は，その後の継続療法の有無によりかなり異なった結果であった。すなわち，継続療法を行った症例の有効率は，72.8～91.7％と高く，一方，継続療法を行わなかった症例の有効率は，16.7～40.0％の間にあった。これらの結果から，温泉療法の即時的効果を保つためには，その後の継続療法が極めて重要であることが示唆された。 kn-abstract=The immediate effects (IEs) and distant effects (DEs) of spa therapy were observed in 67 patients with steroid- dependent intractable asthma (SDIA). (1) The IEs of spa therapy evaluated one week after spa therapy were considerably high, and the efficacy rate was 61.5% in type Ⅰa, 82.7% in type Ⅰb, and 83.4% in type Ⅱ asthmatics. (2) The DEs of spa therapy on SDIA were also observed. The efficacy rate was 50.2% in type Ⅰa, 54.3% in type Ⅰb and 63.7% in type Ⅱ asthmatics. (3) The DEs　of spa therapy were different between cases with and without maintenance therapy (MT).　The efficacy rate of DEs was generally high (72.8～91.7%) in cases with MT, and low (16.7～40.0%) in cases without MT. These results show that MT is very important to keep the IEs of spa therapy high for a long time. en-copyright= kn-copyright= en-aut-name=TanazakiYoshiro en-aut-sei=Tanazaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=4 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=5 ORCID= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=6 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=7 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産科婦人科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院第二内科 en-keyword=lmmediate effects (即時的効果) kn-keyword=lmmediate effects (即時的効果) en-keyword=Distant effects (遠隔効果) kn-keyword=Distant effects (遠隔効果) en-keyword=Maintenance therapy (継続療法) kn-keyword=Maintenance therapy (継続療法) en-keyword=Spa therapy (温泉療法) kn-keyword=Spa therapy (温泉療法) en-keyword=Steroid-dependent intractable asthma (ステロイド依存性重症難治性喘息) kn-keyword=Steroid-dependent intractable asthma (ステロイド依存性重症難治性喘息) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=16 end-page=22 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息患者末梢血好塩基球の抗ヒトIgEおよびカルシウムイオノフォァA23187に対する反応性について kn-title=Basophil reactivity to anti-IgE and calcium ionophore A23187 in patients with bronchial asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息27例および健康人7名を対象に，抗ヒトIgEおよびカルシウムイオノフォァA23187（CaI)刺激時の末梢血好塩基球からのヒスタミン遊離について検討を加えた。(1)抗ヒトIgEおよびCaI刺激時の好塩基球からのヒスタミン遊離は，非アトピー型喘息に比べ，アトピー型喘息において有意に高い値を示した。(2)これらの刺激物質によるヒスタミン遊離は，非使用例に比べ，ステロイド依存性喘息において低い傾向がみられた。また，年齢では39才以下，発症年齢では39才以下でヒズタミン遊離がより高い傾向がみられた。(3)血清IgE値の高い症例の好塩基球は，低い症例に比べより多くのヒスタミンを遊離する傾向がみられた。(4)全般的には，抗ヒトIgE刺激によるヒスタミン遊離とCaI刺激時の遊離との間にはある程度の相関がみられた。以上の結果より，好塩基球の反応性はいろいろの条件下でかなり異なることが示唆された。 kn-abstract=The release of histamine from basophils induced by anti-lgE and calcium ionophore A 23187 ( Cal) was examined in 27 patients with bronchial asthma and 7 healthy subjects, using a whole blood method. (1)The release of histamine induced by anti-IgE and CaI was significantly higher in atopic asthmatics than in non-atopic cases. (2) The histamine release with anti-lgE and CaI was significantly lower in cases with long-term steroid therapy compared to the release in cases without steroid therapy. (3) The release with anti-lgE and CaI was increased in cases with age of 0-39 years and in cases wpth age at onset of 0-39 years. (4) Anti-IgE induced release correlated to a certain extent with the release induced by CaI. These results show that basophil reactivity as expressed by histamine release changes under different conditions. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=4 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=5 ORCID= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=6 ORCID= en-aut-name=KomagoeHaruki en-aut-sei=Komagoe en-aut-mei=Haruki kn-aut-name=駒越春樹 kn-aut-sei=駒越 kn-aut-mei=春樹 aut-affil-num=7 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=8 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=9 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産科婦人科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=Histamine release (ヒスタミン遊離) kn-keyword=Histamine release (ヒスタミン遊離) en-keyword=Basophils (好塩基球) kn-keyword=Basophils (好塩基球) en-keyword=Anti-lgE (抗ヒトIgE) kn-keyword=Anti-lgE (抗ヒトIgE) en-keyword=Calcium ionophore A 23187 (カルシウムイオノフォァA23187) kn-keyword=Calcium ionophore A 23187 (カルシウムイオノフォァA23187) en-keyword=Bronchial asthma (気管支喘息) kn-keyword=Bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=裏表紙・英文目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=125 end-page=131 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=環境病態研報告第57号から第62号までの総目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=表紙・目次 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-sei=Institute for Environmental Medicine, Okayama University Medical Scool en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=132 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=あとがき en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YasudaTatsuji en-aut-sei=Yasuda en-aut-mei=Tatsuji kn-aut-name=保田立二 kn-aut-sei=保田 kn-aut-mei=立二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=71 end-page=75 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The biochemical and biological activities of JUN. kn-title=JUN遺伝子の生化学的、生物学的活性についての考察 en-subtitle= kn-subtitle= en-abstract=V-jun is the oncogene which was isolated from the avian transforming virus ASV17. C-jun is the proto-oncogene of v-jun. The product of the proto-oncogene, c-jun, is a major component of the AP-1 transcription complex. AP-1 regulates the transcription of several genes through its ability to bind specifically to the sequence TGACTCA and variations of this motif. In order to assess the transforming capability of c-jun protein, we have introduced v-jun, the chicken c-jun proto-oncogene and several mutants into a replication competent avian retroviral expression vector (RCAS). Each of those was expressed in CEF and assayed for transformation by focus formation. Analysis of the results reveals that deletion of a region of 27 amino acids near the amino terminus of c-jun and deletion of 3' untranslated sequences are critical in activating the full oncogenic potential of jun. kn-abstract=c-junはニワトリの癌ウイルスから分離された癌遺伝子（v-jun）のproto－oncogeneであり，その遺伝子産物は細胞内転写促進因子AP－1の主成分である。v－jun，c-junのトランスフォーム能を検討するために，我々はv-jun，ニワトリc-jun遺伝子さらにJUN遺伝子の種々の組換え体を複製能を持つレトロウイルスベクター（RCAS）に挿入し，CEF細胞（ニワトリ胎児線維芽細胞）にトランスフェクションした。その結果4か所存在する両者の構造的相違のうち，アミノ末端近くの27アミノ酸の欠損と3' untranslated regionの欠損が十分なトランスフォーム能と転写促進能発現に必須であることが明らかとなった。これらの部分がどのように機能発現に関与しているかは，これからの研究を待たねばならない。 en-copyright= kn-copyright= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=AsaumiNoboru en-aut-sei=Asaumi en-aut-mei=Noboru kn-aut-name=浅海昇 kn-aut-sei=浅海 kn-aut-mei=昇 aut-affil-num=5 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=癌遺伝子 (Oncogene) kn-keyword=癌遺伝子 (Oncogene) en-keyword=JUN遺伝子 (JUN gene) kn-keyword=JUN遺伝子 (JUN gene) en-keyword=レトロウイルスベクター (Retrovirus Vector) kn-keyword=レトロウイルスベクター (Retrovirus Vector) en-keyword=トランスフェクション (Transfection) kn-keyword=トランスフェクション (Transfection) en-keyword=トランスフォーム (Transform) kn-keyword=トランスフォーム (Transform) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=91 end-page=111 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On climatology in Misasa spa (thirteenth report) kn-title=三朝温泉地の気候について（第13報） en-subtitle= kn-subtitle= en-abstract=Climatological data of the last 12 months (1989.1.1-1989.12.31) obtained by the climate autorecording system at the Misasa Medical Branch in Misasa spa, Tottoriken, Japan, are presented. kn-abstract=われわれは1956年以降，三朝温泉地の気候要素について観測を行ってきているが，今回は第13報として，ひきつづき1989年1月1日から1989年12月末日までの1ヵ年の気象観測の資料を報告することとした。なお1985年4月1日以降は自動記録装置が備えられたので，今回の資料はすべてこの自動記録装置によるものである。 en-copyright= kn-copyright= en-aut-name=MatsubaraFumie en-aut-sei=Matsubara en-aut-mei=Fumie kn-aut-name=松原扶美恵 kn-aut-sei=松原 kn-aut-mei=扶美恵 aut-affil-num=1 ORCID= en-aut-name=EndouHiroi en-aut-sei=Endou en-aut-mei=Hiroi kn-aut-name=遠藤裕井 kn-aut-sei=遠藤 kn-aut-mei=裕井 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=76 end-page=79 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Possible participation of viral infection in the onset mechanisms of bronchial asthma kn-title=ウイルス感染による発症が考えられた気管支喘息症例 en-subtitle= kn-subtitle= en-abstract=It is well known that respiratory infection induces asthma attacks. In this paper one case showing possible participation of viral infection in the onset mechanisms of bronchial asthma was reported. A 65-year-old woman was admitted to Misasa Hospital because of moderate asthma attacks. The attacks appeared after upper respiratory infection. Bronchial hyperactivity were increased when she admitted at the hospital, and decreased with the improvement of the asthma symptoms. It is suggested from her clinical course that repiratory infection (especially by virus) may affect the bronchial hyperactivity and IgE synthesis. kn-abstract=ウイルスなどの気道感染により，気管支喘息症状が発症したり，あるいは増悪したりすることが知られている。自験例は65歳の女性で，上気道炎症状に引き続いて，気管支喘息が発症した。臨床症状の軽快とともに気道過敏性・IgE値は低下し，感染による気道過敏性の亢進，IgE型アレルギー反応の機序が関与していると考えられた。これらの結果は喘息患者は気道感染（特にウイルス感染）の予防が必要であり，感染した場合には抗喘息剤とともに抗炎症剤の使用が有用である可能性を示している。 en-copyright= kn-copyright= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=1 ORCID= en-aut-name=MitunobuFumihiro en-aut-sei=Mitunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=気道感染 (Respiratory infection, Virus infection) kn-keyword=気道感染 (Respiratory infection, Virus infection) en-keyword=気道過敏性 (Bronchial hypersensitivity) kn-keyword=気道過敏性 (Bronchial hypersensitivity) en-keyword=lgEアレルギー反応 (Allergic reaction mediated by IgE) kn-keyword=lgEアレルギー反応 (Allergic reaction mediated by IgE) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=80 end-page=83 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of rheumatoid arthritis with hypoproteinemia probably induced by diseasemodifying antirheumatic drug, D-Penicillamine kn-title=経過中に低蛋白血症をきたし抗リウマチ剤の関与が疑われた慢性関節リウマチの1症例 en-subtitle= kn-subtitle= en-abstract=A patient with classical rheumatoid arthritis was treated with D-Penicillamine and other drugs. In the course of treatment, the episodes of hypoproteinemia were found twice. The first hypoproteinemia was improved almostly by supportive therapy and withdrawl of administration of medicines, including D-Penicillamine. The second hypoproteinemia was severe and resistant to the treatment. It was suggested that the agent eliciting hypoproteinemia in this case might be D-Penicillamine. kn-abstract=症例は52歳女性で，慢性関節リウマチ（RA）はclassical，stageIV，　class 2であった。症状は進行性で加療を行うも改善がみられなかった。平成元年11月RA症状の増悪のための再入院後，Penicillamine 100～200　mg，Sulfasalazine 500mgを合せて投与を行ったところ，血沈，CRP等の検査所見は改善傾向を示したが入院時には正常値であった血清蛋白量がその後5.1g／dlまで低下し，下肢浮腫が出現，その後さらに血清蛋白量は4.1g／dlにまで減少した。治療により蛋白量は5.8g／dlにまで回復したが，低蛋白血症の原因としてはD－Penicillamineの関与が疑われた。 en-copyright= kn-copyright= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=1 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=三舩尚志 kn-aut-sei=三舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=慢性関節リウマチ (Rheumatoid arthritis) kn-keyword=慢性関節リウマチ (Rheumatoid arthritis) en-keyword=低蛋白血症 (Hypoproteinemia) kn-keyword=低蛋白血症 (Hypoproteinemia) en-keyword=D-ペニシラミン (D-Penicittamine) kn-keyword=D-ペニシラミン (D-Penicittamine) en-keyword=抗リウマチ剤 (Disease-modifying antirheumatic drug) kn-keyword=抗リウマチ剤 (Disease-modifying antirheumatic drug) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=23 end-page=26 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Prevalence of urinary stress incontinence in women kn-title=三回分院外来における女性の腹圧性尿失禁の実態調査 en-subtitle= kn-subtitle= en-abstract=The prevalence of urinary stress incontinence was investigated in 93 women consulting in our hospital by means of a questionnaire survey. The survey showed that 52.7% of the total cases experienced the loss of urine. 87% of the cases with the loss of urine were the cases with stress incotinence. The prevalence of incontinence increased with age up to 69.2% in the 60's. A positive correlation was found between the number of childbirths and the prevalence of incontinence. kn-abstract=三朝分院外来を訪れた女性患者を対象に尿失禁に関する18項目のアンケート調査を行った。その結果，全体の過半数が尿失禁の経験者であった。腹圧性尿失禁が大部分を占め，高齢になるほど　経産回数が多いほど頻度が高くなる傾向がみられた。そのうちの約1割に尿漏れの頻度と程度が重かった。以上より，尿失禁について積極的な啓蒙，診断，治療の必要性が認められた。 en-copyright= kn-copyright= en-aut-name=OkudaHiroshi en-aut-sei=Okuda en-aut-mei=Hiroshi kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=1 ORCID= en-aut-name=TakatoriAkimasa en-aut-sei=Takatori en-aut-mei=Akimasa kn-aut-name=高取明正 kn-aut-sei=高取 kn-aut-mei=明正 aut-affil-num=2 ORCID= en-aut-name=IzushiMichihiro en-aut-sei=Izushi en-aut-mei=Michihiro kn-aut-name=出石通博 kn-aut-sei=出石 kn-aut-mei=通博 aut-affil-num=3 ORCID= en-aut-name=YoshidaJunko en-aut-sei=Yoshida en-aut-mei=Junko kn-aut-name=吉田順子 kn-aut-sei=吉田 kn-aut-mei=順子 aut-affil-num=4 ORCID= en-aut-name=YamagamiKeiko en-aut-sei=Yamagami en-aut-mei=Keiko kn-aut-name=山上桂子 kn-aut-sei=山上 kn-aut-mei=桂子 aut-affil-num=5 ORCID= en-aut-name=SakataJunko en-aut-sei=Sakata en-aut-mei=Junko kn-aut-name=坂田旬子 kn-aut-sei=坂田 kn-aut-mei=旬子 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産科婦人科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産科婦人科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院薬剤部 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=腹圧性尿失禁 (Urinary stress incontinence) kn-keyword=腹圧性尿失禁 (Urinary stress incontinence) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=32 end-page=37 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=種々の長さのスペーサーをもつハプテン化ボスファチジルエタノールアミンの新しい合成法 kn-title=Synthesis of Haptenated Phosphatidylethanolamine Derivatives Containing Different Length Spacers en-subtitle= kn-subtitle= en-abstract=人工脂質膜であるリボソームにハプテン化ホスファチジルエタノールアミン（PE）を挿入することで，リボソーム膜上での免疫反応の研究が進んでいる。いろいろな因子のなかでリボソーム表面とハプテン基の間のスペーサーの長さも重要な因子であることが判明してきた。このスペーサーの役割を研 究するためには汎用性のある合成法の開発が望まれている。これまでのハプテン基一スペーサー分子を結合する方法は種類の異なるハプテン基をもつ分子群を合成するには煩雑である。そこで種々のスペーサーをもつPEを先に合成することで種類の違うハプテン基をもち，異なるスペーサーをもつハプテン化脂質抗原の合成法を開発した。 kn-abstract=The antigenicity of liposomes sensitized with haptenated phosphatidylethanolamine (PE) and the reactivity of the liposomes with complement depended on the length of the spacer between hapten and PE. To establish the optimal conditions for the assay, haptenated PE's with various length of spacers are required. In the previous method, hapten-spacer molecule was first synthesized to which PE was conjugated. Therefore, even different hapten molecules and different length of spacer molecules were used, every combination of hapten and spacer has to be synthesized. A new procedure for preparing hapten-spacer-PE was described here. We first prepared conjugates between PE and various length of spacer molecule, the terminal of which is an amino residue. These molecules react well with activated hapten molecules, giving a good yield of hapten-spacer-PE. en-copyright= kn-copyright= en-aut-name=IshimoriYoshio en-aut-sei=Ishimori en-aut-mei=Yoshio kn-aut-name=石森義雄 kn-aut-sei=石森 kn-aut-mei=義雄 aut-affil-num=1 ORCID= en-aut-name=YasudaTatuji en-aut-sei=Yasuda en-aut-mei=Tatuji kn-aut-name=保田立二 kn-aut-sei=保田 kn-aut-mei=立二 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=東芝総合研究所化学材料研究所 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設基礎環境病態学分野 en-keyword=Haptenated phosphatidylethanolamine (ハプテン化ホスファチジルエタノールアミン) kn-keyword=Haptenated phosphatidylethanolamine (ハプテン化ホスファチジルエタノールアミン) en-keyword=Spacer (スペーサー) kn-keyword=Spacer (スペーサー) en-keyword=Liposomes (リポソーム) kn-keyword=Liposomes (リポソーム) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=27 end-page=31 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Maternity swimming at M isasa Hospital of Okayama University Medical School-Fourth report. The growth and development of babies who were born from the mothers who experienced the maternity swimming kn-title=岡山大学医学部三朝分院における妊婦水泳 ―第四報，妊婦水泳が児の発育・発達に及ぼす影響について― en-subtitle= kn-subtitle= en-abstract=Seventy babies were born from the mothers who experienced maternity swimming in our hospital. The growth and development of 31 babies that were over 1 years old were investigated by means of a questionnaire survey. 62.5% of the total were answered. This survey showed that no babies had problems with their growth and development. These results suggest that maternal Swimmingmight have no hazardous effects on the fetus. kn-abstract=第1報において妊婦水泳に関する妊婦の認識について報告し，第2報において妊婦水泳の現状とその適応について報告し，第3報にて妊婦水泳が循環器系に与える影響について報告した。今回は，母親が妊婦水泳を行い出生後1年以上経過した児の発育，発達状況についてアンケート調査を行った。その結果，発育e発達状況は艮好であった。現時点で全例正常な発達をしていた。このことより我々の行っている妊婦水泳は児の発育，発達に悪影響を及ぼさないことが確かめられた。 en-copyright= kn-copyright= en-aut-name=OkudaHiroshi en-aut-sei=Okuda en-aut-mei=Hiroshi kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=1 ORCID= en-aut-name=TakatoriAkimasa en-aut-sei=Takatori en-aut-mei=Akimasa kn-aut-name=高取明正 kn-aut-sei=高取 kn-aut-mei=明正 aut-affil-num=2 ORCID= en-aut-name=KondoYuji en-aut-sei=Kondo en-aut-mei=Yuji kn-aut-name=近藤裕司 kn-aut-sei=近藤 kn-aut-mei=裕司 aut-affil-num=3 ORCID= en-aut-name=SakataJunko en-aut-sei=Sakata en-aut-mei=Junko kn-aut-name=坂田旬子 kn-aut-sei=坂田 kn-aut-mei=旬子 aut-affil-num=4 ORCID= en-aut-name=KamimotoManabu en-aut-sei=Kamimoto en-aut-mei=Manabu kn-aut-name=上本学 kn-aut-sei=上本 kn-aut-mei=学 aut-affil-num=5 ORCID= en-aut-name=FujiiJunko en-aut-sei=Fujii en-aut-mei=Junko kn-aut-name=藤井純子 kn-aut-sei=藤井 kn-aut-mei=純子 aut-affil-num=6 ORCID= en-aut-name=MasuiEtsuko en-aut-sei=Masui en-aut-mei=Etsuko kn-aut-name=増井悦子 kn-aut-sei=増井 kn-aut-mei=悦子 aut-affil-num=7 ORCID= en-aut-name=NagaeChiho en-aut-sei=Nagae en-aut-mei=Chiho kn-aut-name=永江智穂 kn-aut-sei=永江 kn-aut-mei=智穂 aut-affil-num=8 ORCID= en-aut-name=KawaharaMitsuko en-aut-sei=Kawahara en-aut-mei=Mitsuko kn-aut-name=河原充子 kn-aut-sei=河原 kn-aut-mei=充子 aut-affil-num=9 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院産婦人科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院リハビリテーション部 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院看護部 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=妊婦水泳 (Maternity swimming) kn-keyword=妊婦水泳 (Maternity swimming) en-keyword=児の発育・発達 (Growth and Development of the child) kn-keyword=児の発育・発達 (Growth and Development of the child) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=16 end-page=22 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Thermological study on the coldness women - Second report. The relationship between the change of atmospheric temperature and body surface temperature in women with complaints of coldness in limbs kn-title=サーモグラフィを用いた冷え性の病態生理学的検討 気温の変化と冷え性患者の皮膚表面温度分布の関係について en-subtitle= kn-subtitle= en-abstract=From January to December in 1990, whole body temperature was measured in 79 women by using a thermotracer 6T66, and was compared to the change of atmospheric temperature.The difference between the highest temperature of the body and the lowest temperature of the limbs was more than 8℃ in women with complaints of coldness of limbs. This difference was observed in 88% of the women complaining coldness when the average atmospheric temperature in a month was more than 15℃. kn-abstract=季節毎の婦人の冷え性患者における全身の皮膚表面温度分布について，サーモグラフィを用いて検討した。その結果以下のことが判明した。1）冷え性は外気温が1カ月の最高気温が20℃，最低気温が10℃，平均気温で15℃以下になると発症しやすくなる。2）外気温が前記の条件において，中間温環境下でサーモグラフィ上，軀幹部の最高温度と四肢部の最低温度の差が8℃以上ある症例では99％の確率で冷えを訴えることが明かとなった。 en-copyright= kn-copyright= en-aut-name=TakatoriAkimasa en-aut-sei=Takatori en-aut-mei=Akimasa kn-aut-name=高取明正 kn-aut-sei=高取 kn-aut-mei=明正 aut-affil-num=1 ORCID= en-aut-name=OkudaHiroshi en-aut-sei=Okuda en-aut-mei=Hiroshi kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=2 ORCID= en-aut-name=SekibaKaoru en-aut-sei=Sekiba en-aut-mei=Kaoru kn-aut-name=関場香 kn-aut-sei=関場 kn-aut-mei=香 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=3 en-affil= kn-affil=岡山大学医学部産科婦人科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=婦人の冷え性 (Coldness in women) kn-keyword=婦人の冷え性 (Coldness in women) en-keyword=サーモグラフィ (Thermography) kn-keyword=サーモグラフィ (Thermography) en-keyword=気温の変化 (Change of atmospheric temperature) kn-keyword=気温の変化 (Change of atmospheric temperature) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=11 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A dietary survey in patients with chronic pancreatitis kn-title=慢性膵炎患者の食事調査 en-subtitle= kn-subtitle= en-abstract=Importance of diet therapy has been emphasized in chronic pancreatitis. However, concrete measures and programs of the diet therapy have remained to be studied. Therefore, Intractable Pancreatic Disease Study Group recently carried out a nation-wide questionnaire survey on the diets in patients with chronic pancreatitis under the auspIces of the Ministry of Health and Welfare. Attendant physicians were requested to report the nutritional states of their patients and the kinds and amounts of foods taken by their patients on three consecutive days. The nutritional state was evaluated by a body weight index calculated by the following formula:Body Weight Index (%) = Present Body Weight / Ideal Body Weight X 100. Daily nutritional intake (calorie, protein, fat, carbohydrate, and others) was calculated by dieticians according to the Food Exchange Table published by the Japanese Association of Diabetes. The present study constitutes a part of the group study. Patients consisted of 44 men and 12 women who fulfilled the diagnostic criteria proposed by the Japanese Society of Gastroenterology;20 men and 3 women had secondary diabetes mellitus. Following results and conclusions were obtained. (1) Average daily calorie intake of the patients was 1,759kcal as compared with 2,057kcal in the general population in Japan. Sixteen patients (28.6%) showed daily calorie intake less than 1,400 kcal and consequently poor nutritional states (6 patients with body weight indices less than 80% and 10 with 80-90%). It is important, therefore, to try to improve the daily calorie intake by increasing the frequency of diets in these patients. (2) Average daily intake of protein was 72.1 g (animal protein 38.1 g), only slightly less than 79.2 g (animal protein 41.7 g) in the general population. However, as many as 16 patients (28.6%) showed daily protein intake of less than 60 g and poor nutritional states as described above. It is important, therfore, to encourage patients to maintain the daily protein intake of more than 60 g by increasing the frequency of diets with oral administration of digestive enzymes. (3) Average daily intake of fat was 39.9 g (animal fat 23.8 g), approximately 20 g less than 58.3 g (animal fat 28.0 g) in the general population. As many as 17 patients (30.4%) showed daily fat intake of less than 30 g , and 16 of the 17 patients showed poor nutritional states as described above. It is important, therefore, to encourage patients to maintain the daily fat intake of more than 30 g (especially by increasing the amounts of vegetable oil) by increasing the frequency of diets with oral administration of digestive enzymes. (4) Average daily intake of carbohydrate was 278 g, almost equal to 289 g in the general population. However, many patients took as much as 48 g of carbohydrate in the from of cakes, plain sugar and alcohol beverages. Seventeen men (39%) and one woman (8%) had continued drinking alcohol beverages even after the diagnosis was made. It is important, therefore, to encourage patients to improve the quality of carbohydrate intake, although it is admittedly difficult to realize the ideal. (5) Intake of vitamins and minerals (especially calcium) also tended to be insufficient. Green vegetables were especially insufficient. (6) In conclusion, it is utmost important in chronic pancreatitis to perform periodical evaluation of nutritional intake and feed back the information to the treatment through a close patient-dietician-doctor relationship. kn-abstract=食事療法は慢性膵炎治療の基本として重要であるが，その具体的な内容についてはあまり明確にされていない。今回，筆者らは慢性膵炎例の食事に関する全国調査の一部を担当したので，その成績を報告し，問題点と対策について考察した。対象は慢性膵炎間欠期の患者56名（男44名，女12名）である。(1)エネルギー摂取量では1日1,400kcal以下が16名（29％）にみられ，肥満度80～90％が7名および80％以下が9名という栄養状態と考え合わせて，食事の回数を増やしてでも摂取エネルギーの改善をはかる必要がある。(2)蛋白質および脂質摂取量についても同様な成績であり，消化酵素剤を投与しながら量的，質的な改善をはかる必要がある。(3)糖質については質的改善をはかる必要がある。(4)ビタミンとミネラルも不足傾向にあった。野菜の摂取不足が顕著であった。(5)診断確定後も禁酒できない患者が男17名(39％)，女1名(8％)にみられ，その指導が重要な課題である。 en-copyright= kn-copyright= en-aut-name=HayashimotoKanae en-aut-sei=Hayashimoto en-aut-mei=Kanae kn-aut-name=林下加奈枝 kn-aut-sei=林下 kn-aut-mei=加奈枝 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=3 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=4 ORCID= en-aut-name=TakumaMasae en-aut-sei=Takuma en-aut-mei=Masae kn-aut-name=田熊正栄 kn-aut-sei=田熊 kn-aut-mei=正栄 aut-affil-num=5 ORCID= en-aut-name=MasuiEtsuko en-aut-sei=Masui en-aut-mei=Etsuko kn-aut-name=増井悦子 kn-aut-sei=増井 kn-aut-mei=悦子 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=8 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=9 ORCID= en-aut-name=IzushiMichihiro en-aut-sei=Izushi en-aut-mei=Michihiro kn-aut-name=出石通博 kn-aut-sei=出石 kn-aut-mei=通博 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=8 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=9 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=慢性膵炎 (Chronic pancreatitis) kn-keyword=慢性膵炎 (Chronic pancreatitis) en-keyword=食事療法 (Diet therapy in chronic pancreatitis) kn-keyword=食事療法 (Diet therapy in chronic pancreatitis) en-keyword=栄養状態 (Nutrition in chronic pancreatitis) kn-keyword=栄養状態 (Nutrition in chronic pancreatitis) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=5 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Trial of a mass screening survery for detecting early pancreatic cancer kn-title=膵集検にかんする研究 en-subtitle= kn-subtitle= en-abstract=To find an effective mass screening method for detecting early pancreatic cancer among asymptomatic populations and patients with vague abdominal symptoms, a prospective study was attempted on 1748 patients who came to Medical Clinic of Misasa Branch Hospital, Okayama University Medical School mostly for a routine annual chek-up from June 1, 1986 through June 30, 1990. These patients underwent first-step screeing tests including serum amylase, elastase I and routine abdominal ultrasonography (US). Consequently 155 patients (8.9% of the total 1748 patients) showed abnormal findings and underwent secondstep tests including US, ERCP and computed tomography. Final diagnosis was early pancreatic cancer in one patient and advanced pancreatic cancer in four. Three of the 5 patients with pancreatic cancer were in their sixties. Detection rate of pancreatic cancer (0.29%) in this series was satisfactory as compared with the results of previous reports with US alone. The rate of second-step examination increased with age. Six hundred and forty-one patients (36.7% of the 1748 patients) underwent follow-up examinations more than one year after the previous test. No pancreatic cancer was detected in the 641 patients. The rate of follow-up examination in patients in their sixties was significantly lower than in those in their forties or fifties. It is important to improve the follow-up rate in patients in their sixties, because they are at a high risk for pancreatic cancer as suggested by the present study. kn-abstract=早期膵癌を発見するためのスクリーニング法を確立するため，1986年6月1日から1990年6月30日までの期間のprospective studyを行った。対象は，人間ドックを目的として来院した患者を主とする三朝分院の外来患者1,748名である。一次スクリーニング検査として，血清アミラーゼ，エラスターゼI，腹部超音波検査（US）を施行し155名の要精検者が得られ，要精検率は8.9％であった。155名の要精検者に，二次検査として，USの再精査，ERCP，腹部CTを施行した。その結果，早期膵癌患者1名，進行膵癌患者4名を発見し，膵癌発見率は0．29％と良好な成績であった。加えて，一次スクリーニングの検査項目を限定することによりcost－benifitを改善することができた。発見された膵癌患者の3名は60歳代であった。また，年代別要精検率は加齢とともに上昇した。1年以後にfollow-up検査を受けた患者の数は641名でfoilow－up率は36．7％であり，そのなかから膵癌は発見されなかった。60歳代のfollow－up率は40歳以上60歳未満のそれにくらべて有意の低値をとった。早期膵癌の見逃しを少なくするためには，今後，60歳代を中心とする患者のfollow－up率をさらに高めることが必要である。 en-copyright= kn-copyright= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=1 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=2 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=3 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=4 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 en-keyword=膵集検 (Mass screening for pancreatic cancer) kn-keyword=膵集検 (Mass screening for pancreatic cancer) en-keyword=膵癌の早期診断 (Early diagnosis of pancreatic cancer) kn-keyword=膵癌の早期診断 (Early diagnosis of pancreatic cancer) en-keyword=早期膵癌 (Small pancreatic cancer) kn-keyword=早期膵癌 (Small pancreatic cancer) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=1 end-page=4 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=カンジダ特異的IgG(4)抗体と気管支喘息 kn-title=Candida-specif ic IgG(4) ant ibodies and bronchial asthma en-subtitle= kn-subtitle= en-abstract=66例の気管支喘息症例を対象に，血清中カンジダ特異的lgG(4)抗体を測定し，その血中レベルと年齢および喘息の重症度との関連について検討を加えた。1．血清カンジダ特異的IgG(4)値は，0～39才，40～59才の年齢層にくらべ，60才以上の年齢層において高く，年齢によりその値が変動することが 示唆された。2．40～59才の年齢層では，血清カンジダ特異的IgG(4)は，ステロイド非使用例にくらべ，ステロイド依存性重症難治性喘息症例で有意の高値を示し，この年齢層では，カンジダ特異的IgG(4)抗体がその発症病態に関連している可能性が示唆された。以上，カンジダ特異的IgG(4)抗体の上昇は，高年齢層の症例（60才以上）では全般的に，また40～59才の年齢層で重症型喘息症例において観察されることが明らかにされた。 kn-abstract=Serum levels of Candida-specific IgG(4) antibodies were examined in 66 patients with bronchial asthma, relating to patient age and asthma severity. 1. The levels of Candida-specific IgG(4) antibodies were the highest in patients with 60+years of age, compared to the levels in cases with 0-39 and 40-59 years of age. 2. In cases with 40-59 years of age, the levels of Candida-specific IgG(4) were significantly higher in cases with long-term steroid therapy (severe intractable asthma) than in cases without steroid regimen. The results suggest that increased levels of Candida-specific IgG(4) were observed in relation to patient age and asthma severity. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=TakatoriAkimasa en-aut-sei=Takatori en-aut-mei=Akimasa kn-aut-name=高取明正 kn-aut-sei=高取 kn-aut-mei=明正 aut-affil-num=6 ORCID= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=7 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産科婦人科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産科婦人科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設成人病学分野 en-keyword=Candida (カンジダ) kn-keyword=Candida (カンジダ) en-keyword=Sepcific IgG(4) (特異的IgG(4)) kn-keyword=Sepcific IgG(4) (特異的IgG(4)) en-keyword=Bronchial asthma (気管支喘息) kn-keyword=Bronchial asthma (気管支喘息) en-keyword=Aging (加齢) kn-keyword=Aging (加齢) en-keyword=Asthma severity (喘息重症度) kn-keyword=Asthma severity (喘息重症度) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=84 end-page=86 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Report on monthly meeting for diabetic patients in Misasa Branch Hospital kn-title=糖尿病教室の報告 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakumaMasae en-aut-sei=Takuma en-aut-mei=Masae kn-aut-name=田熊正栄 kn-aut-sei=田熊 kn-aut-mei=正栄 aut-affil-num=1 ORCID= en-aut-name=MasuiEtsuko en-aut-sei=Masui en-aut-mei=Etsuko kn-aut-name=増井悦子 kn-aut-sei=増井 kn-aut-mei=悦子 aut-affil-num=2 ORCID= en-aut-name=HayashimotoKanae en-aut-sei=Hayashimoto en-aut-mei=Kanae kn-aut-name=林本加奈枝 kn-aut-sei=林本 kn-aut-mei=加奈枝 aut-affil-num=3 ORCID= en-aut-name=AsaumiNoboru en-aut-sei=Asaumi en-aut-mei=Noboru kn-aut-name=浅海昇 kn-aut-sei=浅海 kn-aut-mei=昇 aut-affil-num=4 ORCID= en-aut-name=TachibanaHideo en-aut-sei=Tachibana en-aut-mei=Hideo kn-aut-name=立花英夫 kn-aut-sei=立花 kn-aut-mei=英夫 aut-affil-num=5 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=6 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病等分野 affil-num=7 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病等分野 END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=112 end-page=124 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=業績集 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-sei=岡山大学医学部附属環境病態研究施設，岡山大学医学部附属病院三朝分院 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=87 end-page=90 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=看護部活動報告 ―平成2年度― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三朝分院看護部 kn-aut-sei=三朝分院看護部 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=47 end-page=51 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Motility of basophilic granulocytes and histaminerelease kn-title=好塩基球の運動能とヒスタミン遊離 en-subtitle= kn-subtitle= en-abstract=Morphological changes of basophilic leucocytes from atopic asthmatics were observed in relation to histamine release after the cells were challeuged by a specific allergen, anti-IgE and Ca ionophore A 23187 . 1. Increase in motility and degranulation of basophilic granulocytes were observed after the stimulation with antigen and anti-IgE. The incidence of basophils with oriented movement was siguificantly increased at 36 min and reached the peak at 12-15 min after addition of antigen. 2. A decreased number of basophils, increased cell diameter and increased ratio of the short to long axis diameters were observed with a significant amount of histamine release after antigen and anti-IgE stimulation. 3. Compared to cell reactions to antigen and anti-IgE, Ca ionophore A 23187 stimulation showed more decreased motility and greater increase in the diameter of the cells. kn-abstract=各種刺激物質添加時の好塩基球の形態的変化―運動亢進と膨化，脱顆粒―と化学伝達物質遊離との関連を中心に若干の知見をのべた。まず，抗原刺激時には，(1)運動亢進をきたし，洋梨状を示す好塩基球と膨化，脱顆粒を示す好塩基球の2種類が観察されること，(2)アトピー型喘息の好塩基球は健康人と比べて全般的に運動が抑制されていること，(3)運動亢進の状態としては，random movementとoriented movementがあり，抗原に対応した特徴的な運動亢進はoriented movementであること，(4)運動亢進と膨化，脱顆粒は，連続した一連のものではなく，それぞれ独立した過程を持っていること，などが観察されている。また，刺激物質の種類によって，好塩基球の形態的変化や化学伝達物質遊離の状態が異なることについても報告した。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=NakagawaSaburo en-aut-sei=Nakagawa en-aut-mei=Saburo kn-aut-name=中川三郎 kn-aut-sei=中川 kn-aut-mei=三郎 aut-affil-num=6 ORCID= en-aut-name=SodaRyo en-aut-sei=Soda en-aut-mei=Ryo kn-aut-name=宗田良 kn-aut-sei=宗田 kn-aut-mei=良 aut-affil-num=7 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=8 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=9 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=好塩基球 (Basophils) kn-keyword=好塩基球 (Basophils) en-keyword=抗原 (Antigen) kn-keyword=抗原 (Antigen) en-keyword=運動亢進 (lncreased motility) kn-keyword=運動亢進 (lncreased motility) en-keyword=脱顆粒 (Degranulation) kn-keyword=脱顆粒 (Degranulation) en-keyword=ヒスタミン遊離 (Histamine release) kn-keyword=ヒスタミン遊離 (Histamine release) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=38 end-page=45 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=New immunization procedure for production of monoclonal antibodies which recognize carbohydrate of glycoprotein kn-title=糖タンパク質糖鎖に対するモノクロナール抗体作製のための基礎的研究 en-subtitle= kn-subtitle= en-abstract=New immunization method for production of monoclonal anitibodies which recognize oligosaccharide portion of glycoprotein was developed. Conventional immunization method in which glycoprotein was emulsified with Freund's complete adjuvant could not produce anti-carbohydrate monoclonal antibody. Glycopeptide which was prepared by pronase digestion of glycoprotein conjugated liposomes containing lipid A of Salmonella minnesota were revealed good antigen for prodution of anti-carbohydrate monoclonal anitibodies. By this new immunization method several monoclonal antibodies which recognize mainly carbohydrate portion of ovomucoide were established. kn-abstract=糖タンパク質糖鎖に対するモノクローナル抗体を効率よくとるための免疫方法の検討をおこなった。抗原としては糖鎖のがん性変化のひとつであるbisecting　N－acetyiglucosamine構造をもつオボムコイド（OVM）をとりあげた。OVM全分子を通常のフロインド完全アジュバントでくりかえし感作する方法では糖鎖を認識するモノクローナル抗体をとることはできなかった。またOVMをリポソームニ重膜に挿入する方法でも同様であった。これに対してOVMからプロナーゼ消化により糖ペプチドを調製し，アジュバント活性をもつリピドAを共存させたリポソームに共有結合した抗原を感作したマウスからは高率に糖鎖と反応するモノクローナル抗体をとることができた。しかしながらこれらの抗体はいずれもサブタイプはIgMであった。 en-copyright= kn-copyright= en-aut-name=OoyamaKunio en-aut-sei=Ooyama en-aut-mei=Kunio kn-aut-name=大山邦夫 kn-aut-sei=大山 kn-aut-mei=邦夫 aut-affil-num=1 ORCID= en-aut-name=WataraiShinobu en-aut-sei=Watarai en-aut-mei=Shinobu kn-aut-name=渡来仁 kn-aut-sei=渡来 kn-aut-mei=仁 aut-affil-num=2 ORCID= en-aut-name=YasudaTatsuji en-aut-sei=Yasuda en-aut-mei=Tatsuji kn-aut-name=保田立二 kn-aut-sei=保田 kn-aut-mei=立二 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=現旭化成工業株式会社医療科学研究所 affil-num=2 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設基礎環境病態学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部附属環境病態研究施設基礎環境病態学分野 en-keyword=モノクローナル抗体 (Monoclonal antibody) kn-keyword=モノクローナル抗体 (Monoclonal antibody) en-keyword=糖タンパク質 (glycoprotein) kn-keyword=糖タンパク質 (glycoprotein) en-keyword=オボムコイド (ovmucoide) kn-keyword=オボムコイド (ovmucoide) en-keyword=酵素免疫測定法 (enzyme immunoassay) kn-keyword=酵素免疫測定法 (enzyme immunoassay) en-keyword=リポソーム (liposome) kn-keyword=リポソーム (liposome) en-keyword=lipid A kn-keyword=lipid A END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue= article-no= start-page=52 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Alcohol-induced pancreatitis kn-title=アルコール性膵炎 en-subtitle= kn-subtitle= en-abstract=This paper is to review the literature on the epidemiology, clinical pictures and etiopathogenesis of alcohol-induced pancreatitis (AIP). The incidence of AIP has been increasing worldwide, paralleling the increase in alcohol consumption. AIP manifests itself following a longterm consumption of large amounts of alcohol. There is no known threshold value of alcohol consumption in terms of the risk of developing AIP, although the logarithm of the risk of developing AIP is lineally correlated with the amount of alcohol intake. Why some alcoholics develop pancreatitis whereas others with equal consumption of ethanol are spared remains to be explained. Therefore, two additional factors are considered to play important roles in developing AIP : genetic predisposition and diet. The majority of AIP IS chronic pancreatitis (AICP), although a minority can be acute pancreatitis (AIAP). AIAP shows somewhat higher morbidity and mortality than the common variety of acute pancreatitis. If recovered from an attack, AIAP shows morphological and functional restoration. AICP manifests itself with an acute attack of abdominal pain, insidious onset of abdominal pam, or a pain-free variety. An acute attack in AICP resemble that m AIAP ; often these two can be differentiated only by follow-up studies. AICP shows no morphological and functional restoration, and often shows progressive deterioration. Abdominal pain with elevated serum pancreatic enzymes is a predominant clinical picture m the early stage of AICP, whereas in the late stage symptoms and signs deriving from exocrine insufficiency (maldigestion) and endocrine insufficiency (pancreatic diabetes) begin to dominate the clinical pictures. AICP is in the more advanced stage and shows more complications than nonalcoholic chronic pancreatitis at the time of diagnosis. In addition, AICP shows more rapid progress and higher morbidity and mortality. The incidence of microangiopathy in pancreatic diabetes resemble that in primary diabetes, being higher in patients with a longer history of diabetes, those on insulin treatment and those under poorer control. Main causes of death are development of cancer in the upper respiratory and gastrointestinal tract and diabetic complications (hypoglycemic shock, renal failure, and intractable pneumonia), and acute attack of pancreatitis leads to death less frequently. Ductal-Plug theory and classical Toxic-Metabolic theory are most popular to explain the pathogenesis of AIP ; however, increasing evidence has been reported that oxygen free radicals and intracellular activation of zymogens by lysosomal enzymes may be involved in the pathogenesis. kn-abstract=膵炎のうちもっとも頻度が高いアルコール性膵炎（AIP）の疫学，臨床像および発生機序に関する従来の知見を総括した。AIPの大多数は慢性膵炎である。通常は長期にわたる多量の飲酒を背景に発症するが，遺伝的素因および食事因子も重要な役割を演じる。発症初期には血中膵酵素の上昇をともなう腹痛が病像を支配するが，進展すると膵外分泌不全による消化吸収障害と膵内分泌不全による糖尿病が病像を支配するようになる。アルコール性慢性膵炎は非アルコール性慢性膵炎にくらべて確診時にすでに進展した症例が多く，合併症が多く，進行が早く，予後が悪い。死亡の主たる原因は癌の併発と糖尿病の合併症で，膵炎の急性増悪発作がこれにつぐ。併発する癌のなかでは膵癌よりもむしろ上部気道および上部消化管の癌が多い。発生機序としてはDuctal－Plug説とToxic－Metabolic説が有力であるが，最近は細 胞内膵酵素活性化説とFree　Radical説も注目をあびている。 en-copyright= kn-copyright= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=1 ORCID= en-aut-name=TanakaJuntaro en-aut-sei=Tanaka en-aut-mei=Juntaro kn-aut-name=田中淳太郎 kn-aut-sei=田中 kn-aut-mei=淳太郎 aut-affil-num=2 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=3 ORCID= en-aut-name=MatsumotoShuji en-aut-sei=Matsumoto en-aut-mei=Shuji kn-aut-name=松本秀次 kn-aut-sei=松本 kn-aut-mei=秀次 aut-affil-num=4 ORCID= en-aut-name=SenoToshinobu en-aut-sei=Seno en-aut-mei=Toshinobu kn-aut-name=妹尾敏伸 kn-aut-sei=妹尾 kn-aut-mei=敏伸 aut-affil-num=5 ORCID= en-aut-name=lzushiMichihiro en-aut-sei=lzushi en-aut-mei=Michihiro kn-aut-name=出石通博 kn-aut-sei=出石 kn-aut-mei=通博 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=2 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=3 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=4 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=5 en-affil= kn-affil=岡山大学医学部環境病態研究施設成人病学分野 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 en-keyword=アルコール性膵炎 (Alcohol－induced pancreatitis) kn-keyword=アルコール性膵炎 (Alcohol－induced pancreatitis) en-keyword=慢性膵炎 kn-keyword=慢性膵炎 en-keyword=急性膵炎 kn-keyword=急性膵炎 END