岡山医学会Acta Medica Okayama0030155811912007アデノ随伴ウィルスベクターを用いた局所前立腺癌遺伝子治療の可能性:マスピンの長期発言により腫瘍増殖が効率的に抑制された15ENMasamiWatanabeNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007腎臓再生へ向けた成体腎臓幹/前駆細胞様細胞を用いた再生医療の可能性710ENShinjiKitamuraNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008急性期病院における Discharge Planning を核とした,「高齢者・在宅・緩和医療プロフェッショナル養成コース」の概要15ENHirokazuKomatsuFumihiroMitsunobuHiroyukiDoiNorioKoideNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008EGFR K-ras 遺伝子変異と DNA メチル化異常からみた肺腺癌の発癌機構711ENShinichiToyookaHiroshiDateNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008テロメラーゼ特異的制限増殖型アデノウイルスを用いた転移リンパ節の生体内イメージング1321ENHiroyukiKishimotoToruKojimaYuichiWatanabeShunsukeKagawaToshiyaFujiwaraFutoshiUnoFuminoriTeraishiSatoruKyoHiroyukiMizuguchiYuuriHashimotoYasuoUrataNoriakiTanakaToshiyoshiFujiwaraNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008母子間免疫寛容理論に基づく同種造血幹細胞移植2328ENKen-ichiMatsuokaKazutoshiAoyamaMotokoKoyamaDaigoHashimotoShojiAsakuraTatsuoIchinoheMitsuneTanimotoTakanoriTeshimaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008培養肝細胞を用いたスタチン剤のC型肝炎ウイルス抑制効果について2934ENMasanoriIkedaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008頻回な心室性不整脈を呈した Brugada 症候群に対する低用量 Isoproterenol の治療効果の検討3541ENAtsuyukiWatanabeKengoKusano FukushimaHiroshiMoritaDaijiMiuraWakakoSumidaShigekiHiramatsuKimikazuBanbaNobuhiroNishiiSatoshiNagaseKazufumiNakamuraSatoruSakuragiTohruOheNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008法医生物学におけるイムノアッセイの応用4348ENSatoruMiyaishiNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008マウス精巣吸引針生検後の精細管傷害および対精細胞遅延型過敏反応の解析4954ENHiromuTsuboiThe purpose of this study was to define the histopathological change and immunological response occurring as a result of testicular fine needle aspirations (TEFNAs) in C3H/HeN mice. TEFNA (one-, five-, or twenty-time aspiration) from the left testis was performed on day 0, and bilateral testes were examined histologically on days 21 and 49. Delayed-type hypersensitivity (DTH) was measured as the immunological response. Significant reduction of left testicular weight was observed only in the twenty-time aspiration group, on days 21 and 49. Histological examinations in the left testes showed a significantly high incidence of spermatogenetic disturbance with focal chronic inflammation and degenerative changes on day 21 and 49 after twenty-time TEFNA. Similar but less extensive changes were noted after five-time TEFNA. As for the weight and histology of the right testes, there was no significant change after the left-side TEFNA treatments. However, we revealed that the DTH response to autologous testicular cells was significantly elevated in the twenty-time aspiration group on day 21. In this animal model, TEFNA caused definite damage to the seminiferous tubules and induced DTH against testicular cells. Further study may be required to determine the clinical relevance of such findings to the testes of azoospermic men treated with TEFNA.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008Ⅴ 消化管がんに対する現代の標準的治療 ~外科的治療を中心に~5561ENYoshioNaomotoTomokiYamatsujiYasuhiroShirakawaMunenoriTakaokaYasuhiroFujiwaraShunsukeTanabeNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008Ⅵ 肝がんの外科的治療と再発治療の変遷6367ENTakahitoYagiNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008Ⅶ 卵巣癌・子宮体癌・子宮頸癌の標準的治療6975ENJunichiKodamaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008VIII 悪性骨・軟部腫瘍7781ENToshiyukiKunisadaToshifumiOzakiNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008慢性腎臓病の診断とフォローアップ8386ENMasaruKinomuraHitoshiSugiyamaHirofumiMakinoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008子宮頸癌の取り扱い8789ENYujiHiramatsuNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008薬物相互作用(12―ベンゾジアゼピン系睡眠薬の薬物相互作用)9194ENKazuakiShinomiyaYoshihisaKitamuraSatoshiUeshimaTomoakiSatohToshiakiSendoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008マイクロ RNA9596ENMitsuneTanimotoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008<病院紹介>財団法人積善会附属 十全総合病院9799ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008<病院紹介>しげい病院101103ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008<病院紹介>財団法人慈圭会 慈圭病院105106ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008<学会抄録>第163回 岡山外科会107113ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008<学会抄録>第164回 岡山外科会115120ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812012008<学会抄録>第2回 岡山 QOL 研究会121124ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007A human β-cell line for transplantation therapy to control type 1 diabetes1116ENNaoyaKobayashiSoto GutierrezAlejandroDavid Rivas-CarrilloJorgeNavarro-AlvarezNaluJunHee-SookA WestermanKarenR T LakeyJonathanLeboulchPhilippeYoonJi-WonNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007Cdk5によるインスリン分泌の制御機構1720ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007REIC/Dkk-3遺伝子によるヒト前立腺癌に対する遺伝子治療の基礎実験2126ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007若年女性における血管障害2732ENMikiyaNakatsukaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007ヒト膀胱上皮細胞におけるAurora-A遺伝子の過剰発現と中心体の異常複製, 染色体異常の研究3339ENNoriyoshiTanakaAurora-A/STK15/BTAK kinase encoding gene, located on chromosome 20q13, is frequently amplified and overexpressed in human cancers. Sen et al. previously demonstrated that Aurora-A amplification and overexpression are associated with aneuploidy and clinically aggressive bladder cancer (J Natl Cancer Inst (2002) 94, 1320-1329). To examine if this association is the direct result of Aurora-A gene amplification and overexpression, an immortalized human urothelial cell line (SV-HUC) was infected with an adenoviral Aurora-A-green fluorescent protein (Ad-Aurora-A-GFP) fusion construct inducing ectopic expression of the resulting fusion protein. Controls included mock-infected and adenoviral-GFP infected cells. Ectopic expression of transduced Aurora-A did not alter the doubling time of the SV-HUC cells but significantly increased the number of cells with multiple centrosomes displaying aneuploidy and increased colony formation in soft agar. This is the first report demonstrating that overexpression of Aurora-A induces centrosome anomalies together with chromosomal instability and malignant transformation-associated phenotypic changes in immortalized human urothelial cells, thus supporting the hypothesis that this gene plays an important role in the development of aggressive bladder cancer.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007深部前梨状葉皮質の間欠的電気刺激によるてんかん発作重積モデル4147ENFumihikoKoyamaHippocampal damage induced by status epilepticus (SE) has been suggested as the developmental pathway of temporal lobe epilepsy. We developed an experimental model of SE induced by massed electrical stimulations into the deep prepiriform cortex. Stimulations under aminophylline pretreatment more effectively induced SE than those in the absence of aminophylline. Most SE episodes included secondary generalized seizures. Cresyl violet staining indicated neuronal degeneration in CA1 and CA3, 1-2 weeks after the SE. Mild neuronal loss was observed 8 weeks after the SE, although there were no obvious histological changes in the hilus. Immunoreactivity for GluR1, a subunit of the AMPA receptors, was reduced in CA3 and the hilus starting 1 week after SE, indicating a discrepancy between the distributions of neuronal damage and the GluR1 decrement. The present model serves as a useful model of SE. Further improvement of this method will make it an effective tool for understanding the developmental process of temporal lobe epilepsy.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007日本人Brugada症候群患者における心筋ナトリウムチャネル遺伝子 (SCN5A) の変異と多型4955ENDaijiMiuraBackground: Brugada syndrome is an inherited arrhythmogenic disease characterized by right bundle branch block pattern and ST segment elevation, leading to the change of V1 to V3 on electrocardiogram, and an increased risk of sudden cardiac death resulting from ventricular fibrillation. The sodium channel alpha 5 subunit (SCN5A) gene encodes a cardiac voltage-dependent sodium channel, and SCN5A mutations have been reported in Brugada syndrome. However, single nucleotide polymorphisms (SNPs) and gene mutations have not been well investigated in Japanese patients with Brugada syndrome.
Methods and Results: The SCN5A gene was examined in 58 patients by using PCR and the ABI 3130xl sequencer, revealing 17 SNP patterns and 13 mutations. Of the 13 mutations, 8 were missense mutations (with amino acid change), 4 were silent mutations (without amino acid change), and one case was a mutation within the splicing junction. Six of the eight missense mutations were novel mutations. Interestingly, we detected an R1664H mutation, which was identified originally in long QT syndrome.
Conclusion: We found 13 mutations of the SCN5A gene in 58 patients with Brugada syndrome. The disease may be attributable to some of the mutations and SNPs.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007末梢血行障害による虚血性疼痛に対するモルヒネ内服の効果5760ENHiroyukiNishieSatoshiMizobuchiTakashiMatsusakiAsakoMiyakeRyujiKakuShinichiIshikawaKenjiSatoMasakiMatsumiMoritaKiyoshiPeripheral arterial disease often causes ischemic ulcers due to impaired blood flow and consequentially induces intractable pain. For these patients, we have recently begun to administer morphine orally. In this study, we retrospectively examined the effects of oral morphine for the relief of pain caused by peripheral arterial disease.
Oral morphine was administered to 17 cases of peripheral arterial disease between January, 2004 and February, 2006. The initial dosage was 5 mg or 10 mg, started on an as-needed basis. After the daily dosage of morphine became constant, we divided the dosage into four or six times a day and administered it regularly. With the exception of one case, a small amount of oral morphine, from 20 mg to 70 mg a day, could alleviate patient's pain. Eight cases had side effects such as nausea, constipation or drowsiness.
Oral morphine is effective for pain relief of peripheral arterial disease patients. However, now in Japan, oral morphine, which we can prescribe for those patients with insurance, has a shorter duration of action, so we need to administer slow-release morphine. Oral morphine must be administered carefully because many peripheral arterial disease patients have cardiac disease or renal dysfunction as complications.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007I がん診療連携拠点病院体制と岡山大学病院腫瘍センター6167ENMasahiroTabataNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007II がん登録制度6972ENAkiraGochiHisakoSenamiNaomiOharaMasahiroTabataNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007III がん相談支援7374ENHirokiOkadaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007糖尿病における血糖管理7577ENAtsuhitoToneKenichiShikataHirofumiMakinoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007妊娠糖尿病の取り扱い7981ENYujiHiramatsuNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007薬物相互作用 (9―喫煙と薬の相互作用)8385ENHidenoriSagaraYoshihisaKitamuraToshiakiSendoYutakaGomitaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007Panton-Valentine leukocidin (PVL)8789ENOsamuYamasakiNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007<病院紹介>国立病院機構 岩国医療センター9192ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007<病院紹介>神戸赤十字病院9394ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007岡山県医師会学術奨励賞受賞を記念して9596ENKengoKusanoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811912007<学会抄録>第161回 岡山外科会97101ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007新しい生体肺移植術式 : 両側自己肺温存部分肺移植術107112ENSeiichiroSugimotoHiroshiDateRyujiroSugimotoMasaomiYamaneShinichiToyookaTakahiroOtoMotoiAoeYoshifumiSanoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007食道扁平上皮癌の発癌過程におけるDNAメチル化の役割113117ENTatsuhiroIshiiJunMurakamiKenjiNotoharaHiromiSasamotoTakeshiKambaraYasuhiroShirakawaYoshioNaomotoMamoruOuchidaKenjiShimizuR. JassJeremyNagahideMatsubaraNoriakiTanakaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007統合失調症の分子病態研究について - 遺伝子研究を中心に -119125ENYukitakaMoritaHiroshiUjikeShigetoshiKurodaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007非小細胞肺癌における癌・精巣抗原XAGE-1の発現と免疫応答の解析127129ENKazuhikoNakagawaYujiNoguchiHideoOkumuraShuichiroSatoMotoyukiTanakaMichihideShimonoAli MohamedAli EldibMotoiAoeToshiroOnoAkikoUenakaNobuyaOharaTadashiYoshinoKazukiYamashitaTsukasaTsunodaNobuyoshiShimizuEiichiNakayamaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007医療政策論の現況131136ENJunHamadaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007ソニック・ヘッジホッグ (Sonic hedgehog) を用いた新たな心筋組織の修復137139ENKengoKusanoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007歯科医師の就業状況と診療偶発事故141146ENHiroshiOnoThe relationship between the operational situation of dental treatment and accidents experienced was investigated through questionnaires sent to members of the Kagawa Dental Association. Responses were received from 261 dentists (53% response rate), of whom 113 (43%) had experienced accidents during dental examinations and/or treatment during the past one year. Dentists with a particularly high risk of having accidents were predominantly young males who possessed many medical chairs at their clinic and who daily examined many patients. Those dentists who worked together with two or more colleagues had a lower risk of accidents. These factors should be considered when trying to take preventive measures against accidents during medical examinations and treatment.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007ボツリヌスB型16S毒素のヒト腸管上皮細胞への結合活性の解析147151ENYingjiJinBotulinum neurotoxin produced by Clostridium botulinum type B is a complex of 12S and 16S toxins. 12S toxin consists of a neurotoxin and a nontoxic non-HA (NTNH). The 16S toxin consists of a neurotoxin, an NTNH, and a hemagglutinin (HA). Food-borne botulism is caused by these complex toxins, which are ingested orally and absorbed from the digestive tract across the epithelial barrier lining the gut.
Here we show that the type B 16S toxin, but not the 12S toxin or the neurotoxin, binds to the T84 human intestinal epithelial cell line. We also demonstrate that the HA moiety in the 16S toxin mediates the toxin binding to the cells. The carbohydrates containing a galactose moiety inhibited the binding of the 16S toxin to the T84 cells, and neuraminidase treatment of the cells increased the 16S toxin binding. The binding of the 16S toxin to the neuraminidase-treated cells was also inhibited by carbohydrates containing a galactose moiety. These results suggest that the type B 16S toxin binds to human intestinal epithelial cells via the galactose moiety in the carbohydrate chain on the cell surface.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007臓器提供における態度と意識に関わる諸因子の構造解析 ―日米間の比較を通して153163ENGosen T.IkeguchiThe purpose of this study is to analyze the background factors relating to opinions on organ donation through factorial and structural comparisons between Japanese and Americans. The data were obtained from responses to a questionnaire (371 Japanese and 41 Americans).
The main findings are as follows:
1. Most of the factors, ‘a will for organ donation depending on a recipient’, ‘view of remains’, ‘understanding of brain death’ and so on showed significant differences between Japanese and Americans.
2. Japanese had a better understanding of brain death. On the other hand, the ratio of Americans who were willing to donate an organ was higher than that of Japanese.
3. It was revealed that “the approval of organ donation for the third person, not only for one's family” had an impact for having donor card showing the approval for organ donation. Furthermore, as underlying factors generating differences on organ transplant opinions, differences were found among Japanese between “approval of organ transplant” and the attitude assuming that oneself or a member of one's family was the person concerned with organ transplantation. There were also differences between Japanese and Americans on ideas about a view for life and death such as soul existence or view of remains.
The argument for transplantation in Japan should consider these structural differences.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007メタボリックシンドロームとストレスとの関連 ―岡山県南部健康づくりセンター利用者での検討―165171ENNorifumiKawakitaNobuyukiMiyatakeTomokoTakigawaDa-HongWangKeikiOginoTakeyukiNumataWe compared the status of stress with and without metabolic syndrome in Japanese. We used data for 774 men and 1,136 women who had received annual health checkups at Okayama Southern Institute of Health. Status of stress was evaluated using a stress check provided by the Department of Public Health, Nihon University. Metabolic syndrome is defined by new criteria in Japan. Physical stress was significantly higher in men with metabolic syndrome than in men without it. However, the ability of coping with stress in men with metabolic syndrome was significantly higher than that in men without it. Thus a linkage between metabolic syndrome and the status of stress was characteristic in Japanese men.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007I 外来化学療法における医師の役割173176ENHiroyoshiDoiharaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007II 外来化学療法における看護師の役割177180ENHitomiNishimotoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007III 外来化学療法における薬剤師の役割181186ENSatokoFujiwaraToshiakiSendoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007IV 外来化学療法と緩和医療・在宅療養支援187189ENJunjiMatsuokaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007糖尿病患者における脂質管理191194ENHitomiKataokaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007産婦人科と肺血栓塞栓症/深部静脈血栓症195197ENYujiHiramatsuNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007薬物相互作用 (10―免疫抑制薬の薬物相互作用)199203ENTomoakiSatoSatoshiUeshimaToshiakiSendoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007B型肝炎ウイルスGenotype/subgenotype205207ENToshihiroHigashiNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007<病院紹介>特定医療法人社団同仁会 金光病院209210ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007<病院紹介>医療法人 青山会 西条中央病院211212ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007<会員紹介>日本犯罪学会賞を受賞して213214ENHideoIshizuNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007<会員紹介>岡山県医師会学術奨励賞 (平成18年) を受賞して215216ENFumioOtsukaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811922007<学会抄録>第106回 岡山医学会総会217221ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008関節リウマチの滑膜マクロファージにおける最終糖化産物受容体 (RAGE) の発現亢進223227ENKatsueSunahoriMasahiroYamamuraJiroYamanaKojiTakasugiHirofumiMakinoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008p53 遺伝子を発現するアデノウイルスベクターを用いた肺癌の遺伝子治療229234ENToshiyoshiFujiwaraNoriakiTanakaTo determine the feasibility, safety, humoral immune response, and biological activity of multiple intratumoral injections of Ad5CMV-p53, and to characterize the pharmacokinetics of Ad5CMV-p53 in patients with advanced non-small cell lung cancer (NSCLC). Fifteen patients with histologically confirmed NSCLC and p53 mutations were enrolled into this phase I trial. Nine patients received escalating dose levels of Ad5CMV-p53 (1 × 109 to 1 × 1011 plaque-forming units[PFU]) as monotherapy once every 4 weeks. Six patients were treated on a 28-day schedule with Ad5CMV-p53 in combination with intravenous administration of cisplatin (80 mg/m2). Patients were monitored for toxicity, vector distribution, antibody formation, and tumor response. Fifteen patients received a total of 63 intratumoral injections of Ad5CMV-p53 without dose-limiting toxicity. The most common treatment-related toxicity was a transient fever. Specific p53 transgene expression was detected using reverse-transcriptase polymerase chain reaction in biopsied tumor tissues throughout the period of treatment despite of the presence of neutralizing anti-adenovirus antibody. Distribution studies revealed that the vector was detected in the gargle and plasma, but rarely in the urine. Thirteen of 15 patients were assessable for efficacy; one patient had a partial response (squamous cell carcinoma at the carina), 10 patients had stable disease, with three lasting ≥9 months, and 2 patients had progressive disease. Multiple courses of intratumoral Ad5CMV-p53 injection alone or in combination with intravenous administration of cisplatin were feasible and well tolerated in advanced NSCLC patients, and appeared to provide clinical benefit.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008小胞外過剰ドパミンによるドパミン神経障害における共通因子としてのキノン体生成235239ENIkukoMiyazakiMasatoAsanumaKoMiyoshiNorioOgawaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008医療政策としての治験の推進と医療の質の向上241246ENHiroyukiDoiNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008肺高血圧ラット右室冠毛細管における内皮グリコカリックスの減少を伴う内壁リモデリングとヘモダイナミクスの変化247251ENMasahitoKajiyaWe hypothesized that coronary capillary function is impaired with a decreased glycocalyx layer and uneven inner wall remodeling in right ventricles that are hypertrophied due to pulmonary hypertension (PH). Five-week-old male Sprague-Dawley rats were divided into 2 groups (PH: n=25, control: n=27). In the PH group, Monocrotaline (60 mg/kg SC) was administrated at 5 weeks. Coronary capillary hemodynamics was visualized in vivo at 8 weeks of age using our high-resolution intravital videomicrosopy, and RBC velocities in RV capillaries were evaluated, along with capillary diameters. Configuration of the capillary cast was assessed by a confocal laser scanning microscope. The thickness of the glycocalyx on the capillary endothelial surface was evaluated with Alcian blue 8GX by electron microscopy. RV systolic pressure increased in PH (by 142%, p<0.01). The diameters of capillaries were uneven in PH (coefficient of variation of diameters along capillary trees; 24±8% vs. 11±3%, p<0.05). The thickness of the glycocalyx in PH was less than half that of control (0.20±0.05 vs. 0.45±0.14 μm, p<0.05). RBC velocity was decreased in PH (820±110 vs. 1,100±230 μm/sec, p<0.05). The capillary flow reduction in PH may be closely related to the changes in the glycocalyx and vessel irregularity, resulting in insufficient oxygen supply to the heart.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008ヘリコバクター・ピロリ感染による動脈硬化促進検討モデルとしてのapoe+/-ldlr+/-マウスの有用性253260ENJinhuaCuiAtherosclerosis is closely related to chronic infection. In the present study, we evaluated atherogenesis by gastric infection with Helicobacter pylori (H. pylori) in atherosclerosis-prone apoe+/-ldlr+/- mice. Six- week- old male apoe+/-ldlr+/- mice infected by H. pylori and apoe+/-ldlr+/- control mice were fed with a high cholesterol diet (1%). Eight weeks after the confirmation of infection, the extent of atherosclerosis, anti heat shock protein 60 of H. pylori (Hp-HSP60) serum titers, and the cellular immune responses against Hp-HSP60 were evaluated. Atherosclerosis was promoted by a Th1-mediated reaction against Hp-HSP60, accompanied by production of IFN-γ and IL-12, and mRNA expression of T-bet in the H. pylori -infected apoe+/-ldlr+/- mice. The over-expressed of HSP60 in stressed endothelial cells could be cross-recognized by T cells against Hp-HSP60 and contributed to the atherosclerosis. This mouse model would be useful for analyzing immunological mechanisms of atherogenesis.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008腹水貯留と広範囲な腸管壁の肥厚を伴う好酸球性胃腸炎の1例261265ENHiromiTachibanaDaisukeOgawaKenjiKaharaSouichiroFujiiNobuhikoHayakawaTetsuyaTsurumiTakayoshiMiyakeTadayoshiKunitomoMorihiroOkazakiA 60-year-old woman was admitted to our hospital with abdominal pain and diarrhea. Examination revealed eosinophilia (white blood count, 24,900/ml; eosinophils, 79.9%) and an elevated immunoglobulin E level. Abdominal computed tomography showed fluid collection and diffuse intestinal wall thickening, and biopsy specimens from the stomach, duodenum and colon showed eosinophil infiltration. We diagnosed the patient with eosinophilic gastroenteritis, and started treatment with steroid hormones (predonisolone, 40 mg/day perorally). The patient's symptoms and eosinophilia improved dramatically and she was discharged.
Eosinophilic gastroenteritis is an inflammatory disease characterized by eosinophil infiltration into the gastrointestinal tract. It usually involves the stomach and small intestine, but may also involve the entire whole gastrointestinal tract. Although ascites sometimes complicates this disease, massive ascites, as in our patient, is rare. Here we report a case of eosinophilic gastroenteritis with massive ascites and diffuse intestinal wall thickening. Steroid hormones are an effective treatment for this disease, and early diagnosis and the administration of steroid hormones are essential.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008頭頸部癌における耳鼻咽喉科, 形成外科, 口腔外科3科合同手術の意義 : 2症例における口腔外科の役割を中心に267272ENNobuyoshiMizukawaSusumuTominagaYoshihiroKimataTomooOnodaShigenobuNomiyaNarushiSugiyamaTomoakiKawamotoEikiYamachikaTakaakiUenoShinTakagiThere is a medical team approach used in many hospitals for oral cancer patients. The members are head & neck surgeons and plastic surgeons, or oral surgeons and plastic surgeons. However, in Japan, it is very difficult for oral surgeons to cooperate with head & neck surgeons, except in the case of extractions and oral health care, because both surgeons treat oral carcinomas and there is therefore a conflict in their scope of practice. We believe it desirable for head & neck surgeons to treat oral cancer patients with tumors extending to other regions, and oral surgeons should be in charge of occlusion in head and neck carcinomas. We treated two patients with oral carcinomas in collaboration with head and neck surgeons and plastic surgeons, with head & neck surgeons resecting the tumors, plastic surgeons reconstructing, and oral surgeons (dentists) taking charge of the occlusion for patients in the operating room. This collaboration resulted in patients having good position of the temporomandibular joint and occlusions after the operation. We therefore conclude that this collaborative team approach may be of benefit to the patients.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008I 乳がんの診断と治療273283ENHiroyoshiDoiharaNarutoTairaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008II 肺癌の内科的治療285292ENKatsuyukiKiuraNagioTakigawaIsaoOzeMasayukiYasugiNobuakiOchiDaijiroHaradaMitsuneTanimotoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008III 肺がんの外科的治療 ―肺癌診療ガイドラインを中心に―293300ENYoshifumiSanoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008IV 消化器癌の内科的標準治療301309ENToruYagiYoshiroKawaharaHiroyukiOkadaKojiTakemotoJunKatoYoshiyukiKobayashiHirofumiKawamotoKazuhideYamamotoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008糖尿病患者における血圧管理311313ENMotofumiSasakiKenichiShikataHirofumiMakinoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008低用量経口避妊薬の使用に関するガイドライン315317ENYasuhikoKamadaYujiHiramatsuNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008薬物相互作用 (11―抗がん剤の薬物相互作用)319322ENHisashiMatsunagaToshiakiSendoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008エピジェネティクス323325ENKatsuyoshiTakataTadashiYoshinoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008<病院紹介>医療法人聖医会 佐用中央病院327328ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008<病院紹介>医療法人正寿会 秋山記念病院329330ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008<会員紹介>志賀潔・秦佐八郎記念賞を受賞して331333ENHiromiKumonNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811932008<学会抄録>第162回 岡山外科会335342ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama003015581202200811Rを用いた脳血管に対する新しい蛋白質導入法129133ENTomoyukiOgawaShigekiOnoTomotsuguIchikawaSeijiArimitsuKeisukeOnodaKojiTokunagaKenjiSugiuKazuhitoTomizawaHidekiMatsuiIsaoDateNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008アデノウイルスベクターを用いた REIC/Dkk-3遺伝子導入による前立腺癌の転移抑制効果について135141ENKoheiEdamuraNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008マクロファージスカベンジャー受容体(SR-A)は炎症を制御することにより糖尿病性腎症を抑制する143147ENHitomiKataokaKenichiShikataMotofumiSasakiHirofumiMakinoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008内分泌療法再燃前立腺癌に対する HSV-tk 遺伝子発現アデノウイルスベクター及びガンシクロビルを用いた自殺遺伝子治療臨床研究149152ENYasutomoNasu「前立腺癌に対する herpes simplex virus-thymidine kinase遺伝子発現アデノウイルスベクター及びガンシクロビルを用いた遺伝子治療臨床研究」を実施した.対象となる被験者は内分泌療法中に再燃してきた臨床的に遠隔転移を認めない局所再燃前立腺癌とした.まず herpes simplex virus-thymidine kinase(HSV-tk)遺伝子発現アデノウイルスベクターを単独で腫瘍内に直接投与し,その後ガンシクロビル(ganciclovir:GCV)を全身投与した.
本研究は2001年3月より第1例目の被験者の治療を開始し,平成17年7月に最終登録例である9例目の被験者の治療を実施し,6ヶ月以上観察し,臨床試験を終了とした(8名のべ9症例).
9症例すべてにおいて有意な副作用を認めなかった.また,ウイルスベクター投与後の抗アデノウイルス中和抗体価の上昇は軽度でかつ一過性であった.ウイルスベクター投与後,48時間において採取した組織において mRNA レベルでの HSV-tk 遺伝子の発現が確認された.治療効果の指標として腫瘍マーカーである PSA は9例中6例において低下した.
結論として局所再燃前立腺癌に対し,HSV-tk 遺伝子発現アデノウイルスベクターを単独で局所内投与し,その後ガンシクロビルを全身投与することの安全性および治療効果が確認された.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008中枢神経疾患に対する成体由来神経幹細胞移植153157ENMasahiroKamedaTetsuroShingoKenichiroMuraokaKazuyaTakahashiTakaoYasuharaIsaoDateNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008透析患者における至適血清リン値に関する文献による検討159168ENMakotoTsukijiIn November 2006, The Japanese Society for Dialysis Therapy (JSDT) announced its first guideline, "The guideline for the management of secondary hyperparathyroidism in chronic dialysis patients," which gives the recommended range of management target values, especially for serum phosphorus, corrected serum calcium and serum intact parathyroid hormone concentrations. Recent studies have suggested that these factors are independently associated with mortality, especially increased cardiovascular mortality. In this research we focused on the serum phosphorus concentration because it is the highest clinical factor among these three. We systematically reviewed almost all documents that discussed the relation between serum phosphorus concentration and mortality as well as the "range of the management target value" specified by foreign guidelines from the US, UK, Canada, Australia and other countries. We summarized the finding concerning the serum phosphorus value of dialysis patients (especially the upper bound value). As a result, it was found that the "range of the management target value" varied among these guidelines. The reasons for this variation likely included differences in the measurement day, in the categories of serum phosphorus concentration, and in the exposure conditions among the studies to which the guidelines referred. Moreover, it was concluded that the Japanese guideline announced by the JSDT should be updated based on the results of future studies.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008非機能性膵内分泌腫瘍の1切除例169173ENYosukeTsunemitsuMasaruInagakiRyosukeHamanoManabuNishieNaoyukiTokunagaShinyaOtsukaToshihideOsakiHiromiIwagakiWe report a rare case of a very large nonfunctioning endocrine tumor of the pancreas without malignant histological features. A 63-year-old woman referred for appetite loss and general fatigue was found to have a tumor in the pancreas head. Computed tomography demonstrated a well-defined pancreatic tumor 45mm in diameter with hypervascular staining in the pancreas head. Angiography showed a hypervascular tumor of the pancreas head and a dilatation of the anterior superior and posterior superior pancreaticoduodenal arteries. The preoperative diagnosis was an endocrine tumor of the pancreas, with undeniable malignancy. Pylorus-preserving pancreaticoduodenectomy was performed. The histopathological diagnosis was a benign nonfunctioning endocrine tumor of the pancreas based on immunohistochemical staining for Chromogranin A, Synaptophysin, and NSE, but not for hormones. The tumor revealed a low labeling index (<2.0%) of Ki-67 indicating its benign character. No tumor recurrence has been identified in the 18 months since surgery.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008IX 血液疾患最新の治療 ―造血細胞移植療法の進歩―175184ENKatsujiShinagawaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008X 小児悪性腫瘍に対する治療185191ENKosukeChayamaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008XI 頭頸部がんの標準的治療193200ENSusumuTominagaNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008XII 皮膚がんの診断と標準的治療201206ENMasakiOtsukaKenjiAsagoeKeijiIwatsukiNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008XIII 泌尿器科がんにおける標準的治療207213ENMakotoKobukeYasutomoNasuHiromiKumonNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008慢性腎臓病の治療総論 (降圧療法,食事療法を含めて)215218ENTatsuyukiInoueHitoshiSugiyamaHirofumiMakinoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008水痘感染妊婦の取り扱い219221ENYujiHiramatsuNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008薬物相互作用 (13―下剤の薬物相互作用)223226ENHidekoYokohariMasatoshiOkazakiToshiakiSendoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008舌下免疫療法227229ENMitsuhiroOkanoNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008須崎くろしお病院231232ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008住友金属鉱山株式会社 住友別子病院233234ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008心臓病センター榊原病院235236ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008第165回 岡山外科会237241ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008第166回 岡山外科会243250ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155812022008第107回 岡山医学会総会251255ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811832007モデル動物を用いたタウオパシーの病態解明と有効な薬剤同定:αトコフェロールの効果について193198ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811822006岡山画像診断センターの設立とその役割 (http://www.okayama-dic.or.jp)9398ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811822006中枢神経疾患に対するカプセル化細胞移植99103ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811832007内臓脂肪組織に由来するセリンプロテアーゼ阻害剤:Vaspin の同定肥満状態でインスリン感受性を高める新規アディポサイトカイン215220ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811822006気管冷却下に施行した縦隔リンパ節転移に対するラジオ波焼灼療法105108ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811822006自然免疫/炎症とサイトカイン・シグナル伝達109112ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811822006肺移植の現状113117ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811822006乳癌術前化学療法の効果判定における画像診断 われわれが経験した病理判定と画像診断の不一致症例について119121ENJunjiMatsuokaYokoTabuchiMitsuyaItoRyokoOnoTakakoImadaTakayukiMotokiHiroyosiMatsukawaMasakoOhmoriHiroyukiYanaiYoshioNaomotoNoriakiTanakaPrimary systemic chemotherapy (PSC) in breast cancer prolongs disease-free survival in patients who have obtained pathological complete remission (pCR). In combination with pathological examination, CT and MRI have been used to
evaluate the efficacy of PSC, they generally coincide well with pathological evaluation. We here present two cases showing discrepancies between pathological examination and imaging analysis after PSC in breast cancer. We should
keep such discrepancies in mind to determine the ideal treatment after PSC. An accurate method of evaluating cellular damage by PSC is needed.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811812006テロメラーゼ特異的に増幅するGFP蛋白を用いたマウスの固形腫瘍の胸膜播種の可視化915ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811812006原発性肺高血圧症の病態形成における骨形成蛋白(BMP)Ⅰ型受容体の関与とその意義:肺動脈血管平滑筋細胞を用いた検討1721ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811822006乳管洗浄細胞診が診断に有効であった乳癌の一例123125ENJunjiMatsuokaYokoTabuchiRyokoOnoTakakoImadaTatsuoUmeokaNaokiWatanabeTakayukiMotokiHiroyosiMatsukawaYoshioNaomotoNoriakiTanakaHiroyukiYanaiMasakoOmoriAlthough many modalities have been established to diagnose breast cancers, it is sometimes difficult to reveal nonpalpable cases. Duct lavage cytology was originally established to reveal groups at high risk for breast cancers by detecting metaplastic ductal cells. We report here a case where duct lavage was useful for revealing a small cancer that had been undetected by repeated bloody nipple discharge and cytological examinations. Duct lavage cytology may be of use in cases where nipple discharge of unknown origin persists.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811812006メカノバイオロジー―基礎から臨床まで―2331ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030155811832007蛋白導入システム“Protein Transduction System”を利用したプロテインセラピーの発展と現状について― 悪性脳腫瘍に対する蛋白導入法の利用を中心に ―205208ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811822006非触知乳癌におけるVATSマーカーを用いたエコーガイド下マーキングの有用性127129ENJunjiMatsuokaYokoTabuchiMitsuyaItoRyokoOnoTakakoImadaHiroyosiMatsukawaTakayukiMotokiYoshioNaomotoSusumuKanazawaA preoperative tumor guiding system for nonpalpable breast cancer using a VATS guiding needle (Hakko Co., Ltd., Tokyo Japan) was reported. It was easy to introduce the guiding needle into breast cancers smaller than 1cm under
ultrasonographic observation. Neither bleeding nor infection was experienced. Wound management was easy and painless. This guiding system is very useful for locating and managing nonpalpable breast cancers even in outpatient
settings.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811832007ボツリヌスC型とD型神経毒素を支配するバクテリオファージの遺伝子解析と溶原化の分子機構209213ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811832007IgG4関連自己免疫疾患221224ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811832007環境科学の視点からみたアレルギー疾患の課題と対策251257ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811822006眼科領域のアレルギー性疾患とアトピー性皮膚炎の眼合併症131137ENアレルギー反応の4型, 1型 (lgE依存型反応), 1型 (細胞障害型反応), III型 (免疫複合体型反応), IV型 (細胞免疫型反応) を眼科疾患に当てはめると, I型はアレルギー性結膜疾患, II型は眼類天庖瘡やモーレン (Mooren) 角膜潰瘍などの自己免疫疾患, III型はぶどう球菌アレルギーによる周辺部角膜浸潤, IV型は角膜や結膜ブリクテン, 接触性皮膚炎による眼瞼炎, となる. その他, アレルギー関連疾患として, アトピー性皮膚炎がある. アトピー性皮膚炎は, 小児期の疾患であり, 通常, 皮膚は乾燥している. しかし日本では, 思春期から青年期, さらには成人になってから発症する型がある. この型は, 顔面におこることが多く, しかも皮膚は乾燥しておらず, 湿潤している. アトピー性白内障は, 顔面, 特に眼瞼に皮膚炎がある場合に見られる. 問診すると, 特に就寝時に眼瞼をたたく癖がある. アトピー性網膜剥離は, 通常, 白内障がある眼に起こっている. 硝子体手術を行うと, 硝子体基底部の綿状のきたない混濁がみられ, その近辺に鋸状縁断裂, 毛様体無色素上皮剥離や上皮裂孔がある. 一方, アトピー性白内障がある眼では, 前房水中のフレア値 (蛋白濃度) が上昇している. 以上の事実から, アトピー性皮膚炎の炎症が前眼部に波及し, それに眼瞼をたたくという外傷が加わって白内障や網膜剥離がおこると考えられる.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811812006早期診断し得た食道癌術後静脈血栓塞栓症の2例4145ENTakashiKanazawaNobuyukiWatababeYoshioNaomotoMasahikoKobayashiYasuhiroShirakawaTomokiYamatsujiNaoyaKobayashiTohsiyoshiFujiwaraNagahideMatsubaraHiromiIwagakiJunjiMatsuokaNoriakiTanakaWe encountered two cases of pulmonary embolism (PE)/venous thrombs (DVT) after surgery for esophageal cancer. The first case was a 58-year-old male. He underwent a subtotal esophagectomy and reconstruction using the stomach via the subcutaneus route. His postoperative course was stable; however, 13 days after the operation、 he had an elevated fever and pulmonary thrombi were observed on CT-scan screening. Scintigraphy confirmed the thrombi. An inferior vena cava filter (IVCF) was inserted and anti-coagulation therapy using heparin was started. His fever subsided, and 35 days after the operation, the thrombi disappeared. He was discharged thereafter and is being followed up using warfarin. The second case was a 74-year-old male. He also underwent subtotal esophagectomy and reconstruction using the stomach via the subcutaneus route. A central line was inserted via right femoral vein; however, the artery was injured and pressurization to the vessel was needed. His post-operative course was stable and symptom-free; however, ultrasound screening detected DVT in his right femoral vein. IVCF was mserted and anti-coagulation therapy was begun, thrombi disappeared 8 days after the therapy.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811832007パーキンソン病におけるレビー小体形成のメカニズムに関する研究199203ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-1558118320073-ニトロチロシン225234EN種々の機序により産生された活性窒素種 (reactive nitrogen species) によるチロシン残基のニトロ化による3-ニトロチロシン (3-NT) の生成は, 蛋白質の翻訳後修飾の一つとして広く認められている.種々の炎症性疾患組織では, 一酸化窒素・二酸化窒素・ペルオキシナイトライトといった活性窒素種が異なる機序で産生され, 3-NTの産生に関与している. チロシンニトロ化蛋白質の同定や, 蛋白質分子中のチロシンニトロ化部位が決定できるようになり, 蛋白質の寿命, 蛋白質問相互作用に対する悪影響, 蛋白質機能喪失との関連づけが可能になってきた. 測定法としては, 免疫組織化学的手法, ウェスタンブロッティングによる半定量法から, ELISA, HPLC-ECD, LC-MS/MS, GC-MS/MSを用いた定量的な方法がある. 本総説では, 3-NTについて, その生成機序, 測定方法, 予防医学的応用を述べる.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811812006アレルギー疾患総論とアナフィラキシーについて4752ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811712005桂田富士郎と日本住血吸虫発見100年18ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811712005糖尿病性腎症の発症・進展における炎症機転の関与915ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811712005グリア境界膜に局在する新規遺伝子「リミトリン」の発見1720ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811822006(4)アカウンタビリティとは①149150ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811712005Ikaros dominant-negative isoform の過剰発現は dexamethasone や抗IgM 抗体によるapoptosis 誘導を抑制する2126ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811712005腫瘍細胞におけるIGF-Iレセプターの役割と婦人科癌分子標的治療への応用2733ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811712005複合糖質を可視化する3539ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811822006Fetal origin adult disease (FOAD)157159ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811722005大腸癌におけるKRAS,BRAF 遺伝子突然変異とDNA メチル化97103ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811712005ボツリヌスC型,D型毒素遺伝子の解析による菌の分類に関する研究4146ENYoshihikoSakaguchiClostridium botulinum types C and D toxin production is governed by the specific bacteriophages. A type C phage,c-st,was isolated from a toxigenic strain of C-Stockholm,and its whole genome sequence was determined.The genome was a linear double-stranded 185,681bp DNA with a G+C content of 26.2%, and identical 403-bp sequences were found at each end of the genome. From the DNA research, 198 potential protein-coding regions (ORFs)were identified. The genes for type C progenitor toxin and C3 exoenzyme were identified, but no type D toxin gene was found.A number of genes were homologous to those of a Bacillus subtilis bacteriophage,SP D. On Southern blot analysis between type C and D cell DNAs and the specific probes for H and L chains of C and D
neurotoxins, it became clear that type C and D strains posses only one type of toxin gene.From these findings, it is concluded that cross-neutralization observed between toxins (types C and D)and their antiserums can be caused
by the common-antigens in C and D toxins.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811712005重症胸部外傷後肺膿瘍に対し肺葉切除術を施行し救命できた1例4750ENMichioInukaiShingoIchibaMikakoTsudaNaoyukiFujimuraYoshihitoUjikeSyujiIchiharaMotoiAoiYoshifumiSanoHiroshiDateNobuyoshiShimizuThoracic trauma is rarely managed by major thoracotomy. We report a 61-year-old male patient with pulmonaryabscess after severe thoracic trauma, who was managed successfully by major thoracotomy. The patient was injured after a fall from a height of 6 meters.He developed multiple rib fractures with right flail chest, pulmonary contusion,right hemo-pneumothorax, and subcutaneous emphysema.He was intubated and ventilated, and his chest was drainaged. He had been managed with conservative treatment initially. However he developed a pulmonary
abscess in the right lung that was unresponsive to CT-guided drainage therapy. The right lower lobectomy was performed on the 23rd day after his injury. His general condition greatly recovered and all the chest drains were removed on the 45th post trauma day. He was discharged from the hospital on the 86th post operative day. He was
considered now fully recovered at 7 months after the accident.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811712005③医療の事業経営論/医療業の経営持続性を考える5159ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811722005蛋白導入システムによる薬剤開発と膵島移植への応用105108ENNaoyaKobayashiNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811712005ノロウイルス8586ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811732006活性酸素によるRB タンパクの酸化を介した細胞周期停止187191ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811722005誘導性ヒスタミンはH(2)受容体刺激を介してP.ances-LPS 誘発性肝炎からマウスを保護する109118ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811632005新しい核内受容体 Pregnane X Receptor の生殖生理における役割―岡山大学医学賞(林原賞)を受賞して―215220ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811632005ヒトの大腸癌細胞におけるTNFとINF-αの併用刺激によるApoptosisの増強のメカニズム, 特にNF-κBが誘導するFasの発現の増強を介した新しいシグナル伝達について―岡山大学医学賞(林原賞)を受賞して―221228ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811732006シナプス小胞エンドサイトーシスの制御機構に関する研究193198ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811722005ペンシル型CCD 生体顕微鏡システムを用いたin vivo肺微小循環と肺胞呼吸の同時可視化119125ENTaroMorimotoWe succeeded in visualizing in vivo perialveolar microcirculation and individual alveolar respiration in rats,by our high resolution intravital charge-coupled device videomicroscopy system. To elucidate the relevance and usefullness of our methods, we investigated their behavior 1) under control conditions, 2) during increased tidal volumes (TV), 3)during positive-end expiratory pressure (PEEP) application, and 4)during exposure to hypoxia. We recognized a sheet-like flow pattern in capillaries, and observed semi-collapsed capillaries at end-inspiration while flow continued.The latter indicate existence of“vascular waterfall phenomenon”.When TV was increased from 2.5 to 5ml, the alveolar size was increased from 30±10 to 65±18μm (n=21, p<0.05), and the red blood cell velocities in perialveolar capillary were significantly decreased from 910±210 to 290±140μm/sec (n=21,p<0.05). Following PEEP application with TV of 5ml,the alveolar diameter was increased even more to 80±20μm (n=12,p<0.05)and the flows of microvessels stopped temporarily at end-inspiration.We also visualized that precapillary arterioles clearly constricted from 34±6 to 28±6μm in response to hypoxia (n=9, p<0.05). In conclusion, the intravital pencil lens-probe videomicroscopy can be a powerful tool for in vivo observation of perialveolar microcirculation and alveolar respiration under important physiological conditions such as changing TV, application of PEEP, and exposure to hypoxia.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811632005気管支喘息における高分解能CT (high-resolution computed tomography) による評価の有用性―岡山大学医学賞(砂田賞)を受賞して―229234EN気管支喘息は気道の慢性炎症性疾患であり, 本質的に可逆性障害と考えられるが, 持続的慢性炎症によって生ずる肺実質を含む気道の器質的変化すなわち気道リモデリングが原因で不可逆性気流制限をきたし得ることが知られている. 最近, 高分解能CT (HRCT; high-resolution computed tomography) によって気管支壁肥厚, 気管支拡張, 気腫化, モザイク状低吸収域などの変化の評価が可能であることが報告されている. 気管支喘息患者の気道壁は健常者に比較して肥厚しており, その肥厚の程度は喘息の重症度, 気流制限, 気道反応性に関連していることが明らかになっている. 気道リモデリングを反映するHRCTの異常所見は, 慢性気流制限を有する重症喘息患者においてしばしば認められ, 長期の罹病期間や強い気道炎症と関係するとされている. 我々は, HRCTにおける-950Hounsfield unit (HU) 以下のlow attenuation area (RA(950)) は非喫煙喘息患者においても検出され, 気流制限, 肺気量, 喘息の重症度と相関しているが, 肺拡散能との有意の相関は認めないことを報告してきた. 最近, フラクタル解析によってRA(950)は, 喫煙歴を有する喘息患者では気腫性変化を示すのに対し, 非喫煙喘息患者では非気腫性変化 (過膨張) を示す可能性を示した. さらに, HRCTによって評価された気道壁肥厚およびRA950は, 治療によって改善することが認められており, HRCTは喘息の治療効果判定に有用である可能性が示唆された.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811722005Schönlein-Henoch 紫斑病による腹痛症を呈し,内視鏡所見を観察しえた成人男性の2例127133ENMasayaIwamuroShogenOhyaMasaoYoshiokaTatsuyoNasuTsuneyoshiOgawaMamoruItoShuheiIshiyamaAkikoFujiwaraJunjiShiodeKazuhideYamamotoTatsuyaItoshimaWe describe two cases of adult-onset Schonlein-Henoch purpura with gastrointestinal manifestations. Case 1: A 73-year-old man was admitted to our hospital because of abdominal pain, diarrhea and fever. On physical examination, the abdomen was normal, and there were many palpable petechial hemorrhages on the lower extremities.Skin biopsy revealed infiltrations of lymphocytes, neutrophils and eosinophils into the dermis. A computed tomographic (CT) scan of the abdomen disclosed thickening of the intestinal wall in the duodenum and jejunum.Upper gastrointestinal fiberscopy revealed petechiation on the stomach and erosions on the duodenum. Case 2: A 54-year-old man was admitted to our hospital because of hematochezia.The patient had pharyngitis 4 days before admission, and his serum anti-streptolysion O level was increased.On physical examination, there were faint purpuras on the lower extremities.Skin biopsy revealed a histological image of leukocytoclastic vasculitis. A CT scan of the abdomen disclosed thickening of the intestinal wall in the duodenum, jejunum and ileum.Gastrointestinal fiberscopy revealed petechiation on the stomach and ulceration on the cecum.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811732006ヒストンアセチル化制御による実験的関節炎の抑制199204ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811632005ペルオキシソームの機能とペルオキシソーム病235244ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811632005肺悪性腫瘍のラジオ波治療245250ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811632005West 症候群の薬物療法251255ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811732006Ubiquitin/Proteasome経路を介した核内受容体turnoverにおけるSuppressor for Gal-1の役割205209ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811632005経カテーテル動脈塞栓術にて止血しえた大腸憩室出血の1例257260ENSeikiTakashimaMasayukiManoHideyukiNishiKazumaFukudaSyokitiKomatsubaraWe describe a case of hemorrhage from the colon diverticulum successfully treated by transcatheter arterial embolization. A 64-year-old man, who had been diagnosed with diabetes mellitus but not treated, was seen at our hospital on January 24, 1998 because of anal bleeding. Emergent colonoscopy revealed multiple diverticula at the cecum and ascending colon, one of which was the bleeding point. We tried to stop the bleeding at that time, but failed. Considering the poor risk for laparotomy, we performed a transcatheter arterial embolization. We embolized a marginal artery over about 4 cm by two coils and achieved hemostasis. In conclusion, the technique of a transcatheter arterial embolization is effective for diverticular bleeding especially in the case of a high risk patient.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811732006骨軟部腫瘍診断と治療における近年の進歩211217ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811632005②医療の制度経営論/持続可能性の観点から診る医療保険制度改革261271ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811632005泌尿器科における難治性感染症「尿路バイオフィルム感染症」273279ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811622004石灰沈着を伴うび漫性神経原線維変化病における α-Synuclein 陽性病変から分かること―岡山大学医学賞(新見賞)を受賞して―8996ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811632005多剤耐性結核と肺非結核性抗酸菌症287292ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811622004動脈硬化発生に関わる血管内皮細胞のナノ/マイクロメカニクス解析―岡山大学医学賞 (砂田賞) を受賞して―97101ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811732006ヒトヘルペスウイルス7型のDNA ポリメラーゼサブユニットに対する単クローン抗体の性状と有用性219224ENHikaruNambaA monoclonal antibody (MAb), IK17, was developed and found useful for the analysis of human herpesvirus-7 (HHV7) genome replication. In Western blot analysis, the MAb IK17 specifically detected an HHV7 DNA polymerase subunit,U27 protein,expressed in both Escherichia coli (E.Coli)and HHV7-infected cells.Analysis by the same method of truncated U27 proteins expressed in E. Coli demonstrated that the MAb IK17 recognizes an epitope between amino acid 1 and 133 of the U27 protein.The indirect immunofluorescence (IF)method with MAb IK17 detected an unexpected reduction of U27 protein in the infected cells that were treated with a viral DNA polymerase inhibitor,phosphonoacetic acid (PAA),although no reduction of U27 mRNA was observed in the cells by Northern blot analysis. The data suggest the possible usefulness of the MAb IK17 for obtaining clues to characterize an unknown feature of the U27 protein. Immunoprecipitation experiments with the MAb IK17 enabled to detect at least four U27 protein-associated phosphorylated polypeptides in addition to the U27 protein itself.The result indicates the usefulness of the MAb IK17 for qualitative and quantitative analysis of the U27 proteinassociated viral and cellular factors. These analyses contribute to elucidation of the HHV7 genome replication system.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811622004Ⅱ型 DNAトポイソメラーゼと神経細胞分化103107ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811522005ヒスタミンのIL-18産生誘導とIL-18誘導性免疫反応への関与―岡山大学医学賞(結城賞)を受賞して―8793ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811732006医療における個人情報保護法225234ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811622004高倍率CCD生体顕微鏡システムによる 心拍動 下冠毛細血管の直接観察117123ENTakahikoKiyookaWe visualized the epicardial capillary network of the beating canine heart in vivo, using our high resolution intravital CCD videomicroscopy system, in order to elucidate its functional role under control conditions and during reactive hyperemia (RH). We used 10 hearts of open chest, anesthetized dogs. The pencil-lens videomicroscope probe was placed over capillaries fed by the left anterior descending artery in A-V blocked hearts paced at 60-90 beats per minute. In individual capillaries under control conditions flow was predominant either during systole or during diastole, indicating that the watershed between diastolic arterial and systolic venous flows is located within capillaries. The capillary flow increased rapidly during RH and reached a peak flow-velocity (2.0 ± 0.2 mm/s), twice as high as the control flow-velocity (1.0 ± 0.3 mm/s), with enhancement of intercapillary cross-connection flow. Furthermore, the mean diameter increased by 15% compared with the control value, additionally facilitating oxygen supply to myocardial cells, but there was a time lag of about 1.5 s for refilling the capillaries, indicating their function as capacitance vessels during RH. In conclusion, the coronary capillary network functions as 1) the major watershed between diastolic-dominant arterial and systolic-dominant venous flows, 2) a capacitor, and 3) a local flow amplifier and homogenizer of blood supply during RH.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811522005先天性股関節脱臼に対する overhead traction 法の効果―大腿骨頭に位置および関節唇形態の変化―101108ENKazumiMatsudaThe role of overhead traction in the treatment of development al dislocation of the hip, using two-directional srthrography before and after overhead traction,in 56 hips (47 patients) was investigated. There were 5 males (6 hips) and 42 females (50 hips). Of the 56 hips, 41 were treated before walking age and 15 after walking age. The age at the time of overhead traction ranged from 5 to 22 months (average 9 months). Mau'soriginal traction method was used in 38 hips from 1974 to 1988 and Ishida's modified method in 18 hips from 1989 to 2000, but the results were poorer with the former method. Reduction of the femoral head was considered to be obtained when it moved to the entrance of the acetabulum after overhead traction (19 of 41 hips). The shapes of the anterior and posterior portions of the limbus were corrected in 8 of 52 hips, especially in the cases treated before walking age. The superior portion of the linbus was uncharnged. According to the appearance on images, modifind overhead traction appeared to be effective in achieving reduction, but could not comoletely correct the limbus shape.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811622004① 医療の経営学とは/Introductory Health Policy and Management149155ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811522005下血を主訴として発見された成人 Meckel 憩室に1例119123ENYoshinoriMorimotoHiromiIwagakiNorioMorishitaHitoshiNakagawaNagahideMatsubaraHiroshiIsozakiEisukeKajiHiroyukiOkadaMotooMizunoYasushiShiratoriNoriakiTnakaGastrointestinal bleeding is often intermittent and its souree may be difficult to locate, resulting in delay of definitve diagnosis. Melena usually denotes bleeding not only from the upper, and lower gastrointestine but from the small int estine. Adult Meckel's diverticulum with gastrointestinal beeding is a relatively rare disease and often presents difficulty in preoperative diagnosis. A 65-year-old man was admitted to our hospital due to melena. Upper and lower gastrointestional endoscopy revealed no bleeding stie. (99m)Tc-pertechnetate scintigraphy is well known as a useful tool for preoperative delineation of Meckel's diverticulm. (99m)Tc-pertechnetate scintigraphy was performed in this patient and succesfully depicted the lesion noninvasively. In surgery, Meckel's diverticulum was found at an oral stie 90 cm from the terminalileum, and a sleevereseection was performed. Histopathologically, the diver ticulum had ectopic gastric muco sa and two 5mm ulcers on the border of the gastric mucosa.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811622004難治性の深在性真菌症を発症した子宮頚癌再発患者の1例163167ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811612004神経シナプスにおけるエンドサイトーシス機能タンパク質‐膜リン脂質 相互作用機序の人工脂質膜を用いた解析法―岡山大学医学賞(新見賞)を受賞して―18ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811612004心不全における酸化ストレスの関与:基礎的ならびに臨床的検討 ―岡山大学医学賞(結城賞)を受賞して―916EN心不全患者において血中の過酸化脂質の上昇などが報告され,活性酸素による酸化ストレスの関与が示唆されている.そこで,心筋が実際に活性酸素を発生するかどうかを,活性酸素を検出する蛍光プローブを用いてラットの培養心筋細胞において検討した.心不全増悪因子であるアンジオテンシンIIおよびtumor necrosis factor(TNF)-alphaを加えると心筋細胞で濃度依存性に活性酸素が発生した.さらにヒトの不全心筋においても実際に酸化ストレスの発生が増強しているかを検討した.過酸化脂質の代謝産物で,有害なアルデヒドである4-Hydroxy-2-nonenal(HNE)によって修飾された蛋白質を免疫染色にて調べたところ,拡張型心筋症患者の心筋において正常心機能者に比べ5倍以上増加していた.さらにβ遮断薬(Carvedilol)により治療を行ったところ心機能の改善とともに,HNE修飾蛋白質が40%低下した.以上の一連の研究により,
活性酸素による酸化ストレスの発生が不全心筋において増強しており,その抑制が心不全治療のターゲットの一つになりうることを明らかにした.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811522005神経内視鏡を用いた脳神経外科手術145150ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811612004再生医学から見たパーキンソン病1727ENIsaoDateIt has long been considered that central nervous system would not regenerate after injury, but this concept has recently been changing due to the development of neuroscience research. Cell grafting, gene transfer and neurotrophic factor administration into the brain and spinal cord are the examples of methods to perform protection and repair. These techniques are expected to be applied to certain neurological disorders such as Parkinson's disease, cerebral ischemia and spinal cord injury. Parkinson's disease is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the nigrostriatal system. Fetal neurons, chromaffin cells, cell lines, certain genes, neural stem cells, ES cells and bone marrow cells have been investigated as donor cells and vectors to treat Parkinson's disease. This review will summarize the history of neural transplantation in Parkinson's disease and features and prospects of each donor will be discussed.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811522005気管支喘息155159ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811612004医学教育概説―教育評価とその運用―2938ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811512005クロマティン暗号解明と疾患治療への応用(CREB/CBPをアンカーとして)-Arthritis Investigator Award Hulda Irene Duggan Arthritis Investigator Award を受賞して-17ENそれぞれがノーベル賞の対象となったGプロテイン, サイクリックAMP, プロテインカイネースAという細胞内シグナル情報伝達メインストリームの遺伝子発現における最終的なゴールが転写因子CREB (サイクリックAMPレスポンスエレメント結合タンパク) だった. CREB研究はさらに, 世界で初めての転写因子のリン酸化による遺伝子発現機構の証明, そのシグナル依存的なコアクテイベーターの発見と, いよいよ全貌が明らかとなってきた基本転写因子と外界からのシグナルの接合調節メカニズムの解明においても常に分子生物学をリードしてきた.
我々はCREB研究を通し, クロマテインを加味した新しい遺伝子発現機構を解明し, さらには遺伝子治療, 再生医療への応用において, 最先端の分子生物学と臨床医学をまっすぐに結ぶストラテジーとなりうることを示してきた. 丁度, 打腱器のようにCREBをツールとして使い, その生体内情報系を震わせてやることで, CREB周辺の組織特異的なモレキュラーメカニズムが次々と明らかになってきている. ポストゲノム時代の溢れかえる分子情報のノイズの波に押し流されないためのアンカーとして, そしてサイエンスにおける次のパラダイムの扉をあける鍵として, 古くて新しいCREBそしてクロマテイン研究を, 私たちの研究を中心に紹介したい.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811532004臼蓋形成不全股における関節唇形態の研究203210ENTakuoIshihamaIn dysplastic hips, concentration of the weight and load on the lateral peripheral limbus causes its detachment and tearing, which is an important risk factor of coxarthrosis. Arthrograms of 77 hip joins in 40 patients (all female) with dysplastic hips were used to analyze the covering of the acetabulum and limbus. The average age at the time of arthrograms was 26 years (13-48). The limbus covering angle, a supplement to the CE angle, was added to the CE angle to measure the femoral head cover. Our results demonstrated a negative correlation between the degree of acetabular dysplasia and the length of the limbus. Insufficient bony acetabulums tended to be accompanied by proportionally longer limbi. Also, the limbus was significantly longer in cases with tears, suggesting that a long and unstable limbus might be more likely to undergo tearing, thereby increasing the risk of coxarthrosis.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811612004先天性股関節脱臼に対するColonna法術後の股関節機能維持期間および股関節症発症時期に関する研究3946ENTaisukeNagayasuThe long-term follow-up study of Colonna capsular arthroplasty for developmental dislocation of the hip, especially in terms of duration of the hip function and the onset of coxarthrosis, was investigated. There were 68 hips (63 patients, 54 female and 9 male). The age at the time of the surgery ranged from 11 months to 12 years and 9 months (average 4 years and 3 months). According to the Kaplan-Meier's method, the average survival rate of the hip function was 25 years and 8 months and the survival rate for 25 years was 53%, if the end point was defined as the time hip pain began. Then the average survival rate of hip function was 28 years and the rate was 60.3%, if the end point was defined as the time radiograph showed advanced stage. Clinically, the hip function, especially walking ability, proved to be maintained for long time. The long-term result was worse, when the operation was performed when the patient was older than 6 years old or when patient had previous treatment.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811512005プロアクロシン結合タンパク sp32 前駆体のヒトホモログ遺伝子の同定とがん・精巣 (CT) 抗原-岡山大学医学賞(林原賞)を受賞して-914ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811512005C型慢性肝炎におけるHCV-免疫複合体形成とインターフェロン治療効果との関係1519ENRyoujiManabeWe retrospectively analyzed the relationship between formation of HCV-bearing immune complexes (HCV-IC) and response to interferon (IFN) therapy for chronic hepatitis C (CH-C). Five CH-C patients with complete response (CR) to IFN therapy and pre-treatment HCV RNA titer measured by Amplicor HCV-monitor and five stage (biopsy proved fibrosis of the liver)-matiched CH-C patients who were non-esponders (NR) to IFN therapy were enrolled. Pretretment sera were separated into HCV-IC (supernatant) and anti-HCV antibody-free virions (pellet) by addition of anti-human immunoglobulins and centrifugation. HCV RNA was quantified in the supernatant and the pellet, by real-time PCR and semi-quantitative RT-PCR respectively. There were discrepancies in the HCV RNA titers measured by Amplicor and the results of real-time PCR. We found a larges quantity of HCV RNA in the supernatan and a smaller quantity in the pellet in CR than in NR by using by real-time PCR. Our data indicate that response to interferon therapy for CH-C patients may be associated with the conditions underlying the formation of HCV-IC.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811512005変形性膝関節症における高位脛骨骨切り術後の骨変化-脛骨近位部と膝蓋骨に生じる単純X線写真上の輝度変化-2132ENToruHondaRadiographic brightness was measured in the proximal tibia and patella of 57 knees before and after high tibial osteotomy (HTO) for osteoarthritis. The brightness was converted to the thickness of a reference Aluminum phantom
using NIH Image software. The knees were classified into 4 groups according to the position of the point at which the mechanical axis of the leg intersects the tibial articular surface after HTO, namely "overcorrected" (the position; lateral 0~25%), "adequately corrected" (mid lateral 25~50%), "undercorrected" (mid medial 50~75%), and "correction failure" (medial 75%~). Brightness was high in the lateral and central regions of the proximal tibia in the adequately corrected group, while that of the lateral loading region was high in the overcorrected group. The brightness was broadly high in the undercorrected group, and was not distinct in the correction failure group. In the patella, the brightness of the lateral region was higher than that of the medial region before HTO, and the difference between the two regions was considerably reduced in the adequately corrected group. These findings indicate that adequate correction of leg alignment causes favorable changes in the patellofemoral joint as well as in the femorotibial joint.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811512005外傷後死亡した肺扁平上皮癌を有する高齢者の1部検例-高齢化時代を迎えつつある法医学の立場から-3337ENTakakiIshikawaMasakuniFurusatoKeiYoshitomeSatoruMiyaishiHideoIshizuIn this study, we experienced a case of an elderly man with clinically undiagnosed squamous cell carcinoma of the lung, who died 8 days after a trauma. This case was autopsied because of a question over the causal association between the trauma and death. From the autopsy findings, it was judged that respiratory and metabolic abnormalities due to lung cancer were exacerbated by trauma, and that medically the cause of death should be assessed as death by disease.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-1558115120051. らせんCT検診による微小肺癌の診断4044ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811432003肝臓を標的とした細胞療法243251ENNaoyaKobayashiNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-1558115120054. 中心型肺癌に対するステント療法5962ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811512005重度急性呼吸器症候群SARS6368ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811432003癌抑制遺伝子 ING ファミリーの構造と機能253259ENMehmetGunduzNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811422002Ikaros family とリンパ系腫瘍117123ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811532004耳鼻咽喉科領域における内視鏡下鼻内手術233236ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811422002SEREX法によるマウス移植腫瘍の抗原解析125130ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811432003死体肺移植における一酸化窒素吸入(NO)の有効性と至適投与時間についての実験的検討261266EN肺移植の普及と共に,ドナー不足は深刻な問題となっています.もし心停止ドナーからの肺の使用が可能ならば,ドナーの増加に大きく寄与するものと思われます.しかしながら死体肺移植に関しては,温阻血時間に伴う術後早期の移植肺機能不全が,大きな問題になると予想されます.今回私達は,死体肺移植において,温阻血時間の延長及び呼吸機能の改善に対する一酸化窒素(NO)吸入の有効性と,更にその至適投与時間についての実験的検討を行いました.雑種成犬を用い,ドナーをヘパリン化することなく,心停止後3時間室温にて放置の後,左片肺移植を行いました.移植後対側肺動脈及び気管支を結紮し,移植肺機能を6時間評価しました.100%酸素換気下に,再潅流直前より評価終了時までNO40ppmを持続吸入した群(group 1, n=6),評価開始後1時間までNO40ppmを持続吸入,以後終了時まで,Saturationを一致させるために,窒素40ppmを同じく持続吸入した群(group 2, n=6)及び,再潅流直前より評価終了時まで,窒素を持続吸入した群(group 3,n=6)とを比較検討しました.生存時間,動脈血酸素分圧(PaO(2)),動脈血二酸化炭素分圧(PaCO(2)),湿乾燥重量比(W/D ratio),気道内の吸引量の結果より,NO吸入により虚血再潅流障害軽減による呼吸機能の改善並びに,肺水腫の抑制が示唆されました.またmyeloperoxidase activity (MPO)の有意な低下と,肺血管抵抗(PVR)の低下が認められました. group 1とgroup 2の間には,これらの結果について特に有意な差は認めませんでした.従って,NO吸入が,死体肺移植において,温阻血時間の延長及び呼吸機能の改善に対し有効であり,しかも再潅流直前より短期間の吸入で持続吸入と同様の効果が得られるものと思われます.No potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811412002私たちの導電染色と導電樹脂―山陽新聞賞を受賞して―14ENTakuroMurakamiNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811422002職業性ストレスの健康影響とその対策131132ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811432003スーパーマイクロサージャリーを用いた形成再建外科267274ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811412002腹臥位呼吸管理とARDSの治療戦略上の意義518ENNo potential conflict of interest relevant to this article was reported.岡山医学会Acta Medica Okayama0030-155811422002Helicobacter pylori の胃粘膜防御機構に与える影響133138ENFumiyaYoshinagaUDP-galactosyltransferase (UDP-Gal-T) is a key enzyme in the synthesis of mucus glycoproteins, which play an important role in gastric mucosal defensive mechanisms. Helicobacter pylori (HP) induces gastritis and peptic ulceers but mechanisms of HP-induced mucosal injury sre not fully understood. To elucidate the mechanism whereby (HP) infection induces gastric mucosal injury, we investigated the effects HP on the gastric mucosal defensive mechanism by measuring UDP-Gal T activies in HGC-27, a mucin-producing gastric caneer cell line, treated with various HP-relatd materials (sonicated HP, HP culture supernatants, live HP). HP-related materials induced no significant chages in UDP-Gal T activity, but the enzyme increased when we generated a low concentration of ammonia by adding sonicated HP. and urea simultaneousy. In contrast, UDP-Gal-T activity did not increase when we added live HP instead of sonicated HP. Next, we investigated the effects of HP on ethanol-induced injury in the HGC-27 cells. Pretreatment with ammonia of a low concetration significantly protected cells from ethanol-induced injury. In contrast, pretreatment with live HP and urea generated ammonia of the similar concentration but did not protect cells from the injoy. Our findings that HP has an inhibitory effect against adaptive cytoprotection induced by ammonia by inhibiting the induction of UDP-Gal T.No potential conflict of interest relevant to this article was reported.