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kn-aut-sei=三浦 kn-aut-mei=大二 aut-affil-num=4 ORCID= en-aut-name=SumidaWakako en-aut-sei=Sumida en-aut-mei=Wakako kn-aut-name=角田和歌子 kn-aut-sei=角田 kn-aut-mei=和歌子 aut-affil-num=5 ORCID= en-aut-name=HiramatsuShigeki en-aut-sei=Hiramatsu en-aut-mei=Shigeki kn-aut-name=平松茂樹 kn-aut-sei=平松 kn-aut-mei=茂樹 aut-affil-num=6 ORCID= en-aut-name=BanbaKimikazu en-aut-sei=Banba en-aut-mei=Kimikazu kn-aut-name=伴場主一 kn-aut-sei=伴場 kn-aut-mei=主一 aut-affil-num=7 ORCID= en-aut-name=NishiiNobuhiro en-aut-sei=Nishii en-aut-mei=Nobuhiro kn-aut-name=西井伸洋 kn-aut-sei=西井 kn-aut-mei=伸洋 aut-affil-num=8 ORCID= en-aut-name=NagaseSatoshi en-aut-sei=Nagase en-aut-mei=Satoshi kn-aut-name=永瀬聡 kn-aut-sei=永瀬 kn-aut-mei=聡 aut-affil-num=9 ORCID= en-aut-name=NakamuraKazufumi en-aut-sei=Nakamura en-aut-mei=Kazufumi kn-aut-name=中村一文 kn-aut-sei=中村 kn-aut-mei=一文 aut-affil-num=10 ORCID= en-aut-name=SakuragiSatoru en-aut-sei=Sakuragi en-aut-mei=Satoru kn-aut-name=桜木悟 kn-aut-sei=桜木 kn-aut-mei=悟 aut-affil-num=11 ORCID= en-aut-name=OheTohru en-aut-sei=Ohe en-aut-mei=Tohru kn-aut-name=大江透 kn-aut-sei=大江 kn-aut-mei=透 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=福山市民病院　循環器科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　循環器内科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　循環器内科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　循環器内科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　循環器内科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　循環器内科学 affil-num=7 en-affil= kn-affil=高知医療センター affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　循環器内科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　循環器内科学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　循環器内科学 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　循環器内科学 affil-num=12 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　循環器内科学 en-keyword=Isoproterenol kn-keyword=Isoproterenol en-keyword=Brugada syndrome kn-keyword=Brugada syndrome en-keyword=Ventricular arrhythmia kn-keyword=Ventricular arrhythmia END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=43 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immunoassays in forensic biology kn-title=法医生物学におけるイムノアッセイの応用 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MiyaishiSatoru en-aut-sei=Miyaishi en-aut-mei=Satoru kn-aut-name=宮石智 kn-aut-sei=宮石 kn-aut-mei=智 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　法医学 en-keyword=イムノアッセイ kn-keyword=イムノアッセイ en-keyword=法医学 kn-keyword=法医学 en-keyword=法医生物学 kn-keyword=法医生物学 END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=49 end-page=54 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Testicular fine needle aspirations cause histological injuryand immunological response in mouse testis kn-title=マウス精巣吸引針生検後の精細管傷害および対精細胞遅延型過敏反応の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The purpose of this study was to define the histopathological change and immunological response occurring as a result of testicular fine needle aspirations (TEFNAs) in C3H/HeN mice. TEFNA (one-, five-, or twenty-time aspiration) from the left testis was performed on day 0, and bilateral testes were examined histologically on days 21 and 49. Delayed-type hypersensitivity (DTH) was measured as the immunological response. Significant reduction of left testicular weight was observed only in the twenty-time aspiration group, on days 21 and 49. Histological examinations in the left testes showed a significantly high incidence of spermatogenetic disturbance with focal chronic inflammation and degenerative changes on day 21 and 49 after twenty-time TEFNA. Similar but less extensive changes were noted after five-time TEFNA. As for the weight and histology of the right testes, there was no significant change after the left-side TEFNA treatments. However, we revealed that the DTH response to autologous testicular cells was significantly elevated in the twenty-time aspiration group on day 21. In this animal model, TEFNA caused definite damage to the seminiferous tubules and induced DTH against testicular cells. Further study may be required to determine the clinical relevance of such findings to the testes of azoospermic men treated with TEFNA. en-copyright= kn-copyright= en-aut-name=TsuboiHiromu en-aut-sei=Tsuboi en-aut-mei=Hiromu kn-aut-name=坪井啓 kn-aut-sei=坪井 kn-aut-mei=啓 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　泌尿器病態学 en-keyword=精巣生検（testicular biopsy） kn-keyword=精巣生検（testicular biopsy） en-keyword=精巣損傷（testicular injurly） kn-keyword=精巣損傷（testicular injurly） en-keyword=精子形成（spermatogenesis） kn-keyword=精子形成（spermatogenesis） en-keyword=遅延型過敏反応（delayed-type hypersensitivity） kn-keyword=遅延型過敏反応（delayed-type hypersensitivity） en-keyword=自己免疫性精巣炎（autoimmune orchitis） kn-keyword=自己免疫性精巣炎（autoimmune orchitis） END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=55 end-page=61 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Current standard of surgical treatment in gastrointesteinal cancers kn-title=Ⅴ　消化管がんに対する現代の標準的治療　～外科的治療を中心に～ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=1 ORCID= en-aut-name=YamatsujiTomoki en-aut-sei=Yamatsuji en-aut-mei=Tomoki kn-aut-name=山辻知樹 kn-aut-sei=山辻 kn-aut-mei=知樹 aut-affil-num=2 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name=白川靖博 kn-aut-sei=白川 kn-aut-mei=靖博 aut-affil-num=3 ORCID= en-aut-name=TakaokaMunenori en-aut-sei=Takaoka en-aut-mei=Munenori kn-aut-name=高岡宗徳 kn-aut-sei=高岡 kn-aut-mei=宗徳 aut-affil-num=4 ORCID= en-aut-name=FujiwaraYasuhiro en-aut-sei=Fujiwara en-aut-mei=Yasuhiro kn-aut-name=藤原康宏 kn-aut-sei=藤原 kn-aut-mei=康宏 aut-affil-num=5 ORCID= en-aut-name=TanabeShunsuke en-aut-sei=Tanabe en-aut-mei=Shunsuke kn-aut-name=田辺俊介 kn-aut-sei=田辺 kn-aut-mei=俊介 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 en-keyword=消化管がん kn-keyword=消化管がん en-keyword=標準治療 kn-keyword=標準治療 en-keyword=食道がん kn-keyword=食道がん en-keyword=胃がん kn-keyword=胃がん en-keyword=大腸がん kn-keyword=大腸がん END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=63 end-page=67 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Surgery for hepatocellular carcinoma and the change to be made to therapeutic arms in case of recurrence afterhepatectomy kn-title=Ⅵ　肝がんの外科的治療と再発治療の変遷 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YagiTakahito en-aut-sei=Yagi en-aut-mei=Takahito kn-aut-name=八木孝仁 kn-aut-sei=八木 kn-aut-mei=孝仁 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　肝胆膵外科 en-keyword=肝癌 kn-keyword=肝癌 en-keyword=肝切除 kn-keyword=肝切除 en-keyword=再発 kn-keyword=再発 en-keyword=RFA kn-keyword=RFA END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=69 end-page=75 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Standard treatment of ovarian， endometrial and cervical cancers kn-title=Ⅶ 卵巣癌・子宮体癌・子宮頸癌の標準的治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KodamaJunichi en-aut-sei=Kodama en-aut-mei=Junichi kn-aut-name=児玉順一 kn-aut-sei=児玉 kn-aut-mei=順一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　産科・婦人科学 en-keyword=卵巣癌 kn-keyword=卵巣癌 en-keyword=子宮体癌 kn-keyword=子宮体癌 en-keyword=子宮頸癌 kn-keyword=子宮頸癌 en-keyword=標準的治療 kn-keyword=標準的治療 en-keyword=ガイドライン kn-keyword=ガイドライン END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=77 end-page=81 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Malignant bone and soft tissue tumors kn-title=VIII 悪性骨・軟部腫瘍 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KunisadaToshiyuki en-aut-sei=Kunisada en-aut-mei=Toshiyuki kn-aut-name=国定俊之 kn-aut-sei=国定 kn-aut-mei=俊之 aut-affil-num=1 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name=尾﨑敏文 kn-aut-sei=尾﨑 kn-aut-mei=敏文 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　運動器医療材料開発講座 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学 en-keyword=Bone kn-keyword=Bone en-keyword=Soft tissue kn-keyword=Soft tissue en-keyword=Tumor kn-keyword=Tumor en-keyword=Sarcoma kn-keyword=Sarcoma en-keyword=Malignant tumor kn-keyword=Malignant tumor END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=83 end-page=86 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The diagnosis and follow-up of chronic kidney disease kn-title=慢性腎臓病の診断とフォローアップ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KinomuraMasaru en-aut-sei=Kinomura en-aut-mei=Masaru kn-aut-name=木野村賢 kn-aut-sei=木野村 kn-aut-mei=賢 aut-affil-num=1 ORCID= en-aut-name=SugiyamaHitoshi en-aut-sei=Sugiyama en-aut-mei=Hitoshi kn-aut-name=杉山斉 kn-aut-sei=杉山 kn-aut-mei=斉 aut-affil-num=2 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name=槇野博史 kn-aut-sei=槇野 kn-aut-mei=博史 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎･免疫･内分泌代謝内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　慢性腎臓病対策腎不全治療学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎･免疫･内分泌代謝内科学 END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=87 end-page=89 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Management of uterine cervical cancer kn-title=子宮頸癌の取り扱い en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HiramatsuYuji en-aut-sei=Hiramatsu en-aut-mei=Yuji kn-aut-name=平松祐司 kn-aut-sei=平松 kn-aut-mei=祐司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬総合研究科　産科・婦人科学 END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=91 end-page=94 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Drug interaction(12. Combination with benzodiazepine hypnotics) kn-title=薬物相互作用(12―ベンゾジアゼピン系睡眠薬の薬物相互作用） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ShinomiyaKazuaki en-aut-sei=Shinomiya en-aut-mei=Kazuaki kn-aut-name=四宮一昭 kn-aut-sei=四宮 kn-aut-mei=一昭 aut-affil-num=1 ORCID= en-aut-name=KitamuraYoshihisa en-aut-sei=Kitamura en-aut-mei=Yoshihisa kn-aut-name=北村佳久 kn-aut-sei=北村 kn-aut-mei=佳久 aut-affil-num=2 ORCID= en-aut-name=UeshimaSatoshi en-aut-sei=Ueshima en-aut-mei=Satoshi kn-aut-name=上島智 kn-aut-sei=上島 kn-aut-mei=智 aut-affil-num=3 ORCID= en-aut-name=SatohTomoaki en-aut-sei=Satoh en-aut-mei=Tomoaki kn-aut-name=佐藤智昭 kn-aut-sei=佐藤 kn-aut-mei=智昭 aut-affil-num=4 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name=千堂年昭 kn-aut-sei=千堂 kn-aut-mei=年昭 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　医薬管理学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　医薬管理学 affil-num=3 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　薬剤部 affil-num=4 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　薬剤部 affil-num=5 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　薬剤部 END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=95 end-page=96 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=MicroRNAs kn-title=マイクロ RNA en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name=谷本光音 kn-aut-sei=谷本 kn-aut-mei=光音 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学 END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=97 end-page=99 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=<病院紹介>財団法人積善会附属　十全総合病院 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松尾嘉禮 kn-aut-sei=松尾 kn-aut-mei=嘉禮 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=101 end-page=103 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=<病院紹介>しげい病院 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=重井文博 kn-aut-sei=重井 kn-aut-mei=文博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=105 end-page=106 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=<病院紹介>財団法人慈圭会　慈圭病院 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=武田俊彦 kn-aut-sei=武田 kn-aut-mei=俊彦 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=堀井茂男 kn-aut-sei=堀井 kn-aut-mei=茂男 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=107 end-page=113 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=<学会抄録>第163回　岡山外科会 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=伊達洋至 kn-aut-sei=伊達 kn-aut-mei=洋至 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=115 end-page=120 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=<学会抄録>第164回　岡山外科会 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=東良平 kn-aut-sei=東 kn-aut-mei=良平 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=1 article-no= start-page=121 end-page=124 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=<学会抄録>第2回　岡山 QOL 研究会 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=11 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A human β-cell line for transplantation therapy to control type 1 diabetes en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=成島道樹 kn-aut-sei=成島 kn-aut-mei=道樹 aut-affil-num=1 ORCID= en-aut-name=KobayashiNaoya en-aut-sei=Kobayashi en-aut-mei=Naoya kn-aut-name=小林直哉 kn-aut-sei=小林 kn-aut-mei=直哉 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=興津輝 kn-aut-sei=興津 kn-aut-mei=輝 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田中斎仁 kn-aut-sei=田中 kn-aut-mei=斎仁 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=李順愛 kn-aut-sei=李 kn-aut-mei=順愛 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=陳勇 kn-aut-sei=陳 kn-aut-mei=勇 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三木厚 kn-aut-sei=三木 kn-aut-mei=厚 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田中公章 kn-aut-sei=田中 kn-aut-mei=公章 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中路修平 kn-aut-sei=中路 kn-aut-mei=修平 aut-affil-num=9 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=竹居孝二 kn-aut-sei=竹居 kn-aut-mei=孝二 aut-affil-num=10 ORCID= en-aut-name=AlejandroSoto Gutierrez en-aut-sei=Alejandro en-aut-mei=Soto Gutierrez kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=JorgeDavid Rivas-Carrillo en-aut-sei=Jorge en-aut-mei=David Rivas-Carrillo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=NaluNavarro-Alvarez en-aut-sei=Nalu en-aut-mei=Navarro-Alvarez kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=Hee-SookJun en-aut-sei=Hee-Sook en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=KarenA Westerman en-aut-sei=Karen en-aut-mei=A Westerman kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=野口洋文 kn-aut-sei=野口 kn-aut-mei=洋文 aut-affil-num=16 ORCID= en-aut-name=JonathanR T Lakey en-aut-sei=Jonathan en-aut-mei=R T Lakey kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=PhilippeLeboulch en-aut-sei=Philippe en-aut-mei=Leboulch kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=19 ORCID= en-aut-name=Ji-WonYoon en-aut-sei=Ji-Won en-aut-mei=Yoon kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=3 en-affil= kn-affil=京都大学医学部附属病院　移植外科 affil-num=4 en-affil= kn-affil=クラレメディカル株式会社 affil-num=5 en-affil= kn-affil=岡山大学大学院医薬学総合研究科　生化学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=9 en-affil= kn-affil=クラレメディカル株式会社 affil-num=10 en-affil= kn-affil=岡山大学大学院医薬学総合研究科　生化学 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=12 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=13 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=14 en-affil= kn-affil=Rosalind Franklin Comprehensive Diabetes Center､ Chicago Medical School affil-num=15 en-affil= kn-affil=Massachusetts Institute of Technology､ Division of Health Sciences and Technology affil-num=16 en-affil= kn-affil=京都大学医学部附属病院　移植外科 affil-num=17 en-affil= kn-affil=hHuman Pancreatic Islet Transplant Program､ The University of Alberta Harvard Medical School affil-num=18 en-affil= kn-affil=Massachusetts Institute of Technology､ Division of Health Sciences and Technology affil-num=19 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=20 en-affil= kn-affil=Rosalind Franklin Comprehensive Diabetes Center､ Chicago Medical School en-keyword=ヒト膵 beta 細胞株 kn-keyword=ヒト膵 beta 細胞株 en-keyword=可逆性不死化 kn-keyword=可逆性不死化 en-keyword=細胞移植 kn-keyword=細胞移植 en-keyword=１型糖尿病 kn-keyword=１型糖尿病 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=17 end-page=20 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Molecular mechanism on Cdk5-dependent insulin secretion kn-title=Cdk5によるインスリン分泌の制御機構 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=魏范研 kn-aut-sei=魏 kn-aut-mei=范研 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=長嶋一昭 kn-aut-sei=長嶋 kn-aut-mei=一昭 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大島登志男 kn-aut-sei=大島 kn-aut-mei=登志男 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=佐伯恭範 kn-aut-sei=佐伯 kn-aut-mei=恭範 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=陸雲飛 kn-aut-sei=陸 kn-aut-mei=雲飛 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松下正之 kn-aut-sei=松下 kn-aut-mei=正之 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山田祐一郎 kn-aut-sei=山田 kn-aut-mei=祐一郎 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=御子柴克彦 kn-aut-sei=御子柴 kn-aut-mei=克彦 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=清野裕 kn-aut-sei=清野 kn-aut-mei=裕 aut-affil-num=9 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松井秀樹 kn-aut-sei=松井 kn-aut-mei=秀樹 aut-affil-num=10 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=富澤一仁 kn-aut-sei=富澤 kn-aut-mei=一仁 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学 affil-num=2 en-affil= kn-affil=京都大学大学院医学研究科　糖尿病栄養内科 affil-num=3 en-affil= kn-affil=理化学研究所　発生神経生物研究チーム affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学 affil-num=7 en-affil= kn-affil=京都大学大学院医学研究科　糖尿病栄養内科 affil-num=8 en-affil= kn-affil=理化学研究所　発生神経生物研究チーム affil-num=9 en-affil= kn-affil=京都大学大学院医学研究科　糖尿病栄養内科 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学 en-keyword=Insulin kn-keyword=Insulin en-keyword=Cdk5 kn-keyword=Cdk5 en-keyword=Calcium kn-keyword=Calcium END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=21 end-page=26 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Adenovirus-mediated overexpression of REIC/Dkk-3 selectively induces apoptosis in human prostate cancer cells through activation of c-jun-NH2-kinase kn-title=REIC/Dkk-3遺伝子によるヒト前立腺癌に対する遺伝子治療の基礎実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=FernandoAbarzua kn-aut-sei=Fernando kn-aut-mei=Abarzua aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 en-keyword=前立腺癌 kn-keyword=前立腺癌 en-keyword=REIC/Dkk-3 kn-keyword=REIC/Dkk-3 en-keyword=アポトーシス kn-keyword=アポトーシス en-keyword=JNK kn-keyword=JNK END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=27 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Vascular dysfunction in young women kn-title=若年女性における血管障害 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakatsukaMikiya en-aut-sei=Nakatsuka en-aut-mei=Mikiya kn-aut-name=中塚幹也 kn-aut-sei=中塚 kn-aut-mei=幹也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院保健学研究科 成育加齢領域 en-keyword=血管障害 kn-keyword=血管障害 en-keyword=酸化ストレス kn-keyword=酸化ストレス en-keyword=思春期やせ症 kn-keyword=思春期やせ症 en-keyword=多嚢胞性卵巣症候群 kn-keyword=多嚢胞性卵巣症候群 en-keyword=不育症 kn-keyword=不育症 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=33 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Aurora-A/STK15/BTAK overexpression induces centrosome amplification, chromosomal instability, and transformation in human urothelial cells kn-title=ヒト膀胱上皮細胞におけるAurora-A遺伝子の過剰発現と中心体の異常複製, 染色体異常の研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Aurora-A/STK15/BTAK kinase encoding gene, located on chromosome 20q13, is frequently amplified and overexpressed in human cancers. Sen et al. previously demonstrated that Aurora-A amplification and overexpression are associated with aneuploidy and clinically aggressive bladder cancer (J Natl Cancer Inst (2002) 94, 1320-1329). To examine if this association is the direct result of Aurora-A gene amplification and overexpression, an immortalized human urothelial cell line (SV-HUC) was infected with an adenoviral Aurora-A-green fluorescent protein (Ad-Aurora-A-GFP) fusion construct inducing ectopic expression of the resulting fusion protein. Controls included mock-infected and adenoviral-GFP infected cells. Ectopic expression of transduced Aurora-A did not alter the doubling time of the SV-HUC cells but significantly increased the number of cells with multiple centrosomes displaying aneuploidy and increased colony formation in soft agar. This is the first report demonstrating that overexpression of Aurora-A induces centrosome anomalies together with chromosomal instability and malignant transformation-associated phenotypic changes in immortalized human urothelial cells, thus supporting the hypothesis that this gene plays an important role in the development of aggressive bladder cancer. en-copyright= kn-copyright= en-aut-name=TanakaNoriyoshi en-aut-sei=Tanaka en-aut-mei=Noriyoshi kn-aut-name=田中規幹 kn-aut-sei=田中 kn-aut-mei=規幹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 分子遺伝学 en-keyword=オーロラキナーゼ-A (Aurora-A) kn-keyword=オーロラキナーゼ-A (Aurora-A) en-keyword=中心体 (centrosome) kn-keyword=中心体 (centrosome) en-keyword=染色体不安定性 (chromosomal instability) kn-keyword=染色体不安定性 (chromosomal instability) en-keyword=膀胱癌 (bladder cancer) kn-keyword=膀胱癌 (bladder cancer) END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=41 end-page=47 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An animal model of status epilepticus induced by massed electrical stimulations to the deep prepiriform cortex kn-title=深部前梨状葉皮質の間欠的電気刺激によるてんかん発作重積モデル en-subtitle= kn-subtitle= en-abstract= kn-abstract=Hippocampal damage induced by status epilepticus (SE) has been suggested as the developmental pathway of temporal lobe epilepsy. We developed an experimental model of SE induced by massed electrical stimulations into the deep prepiriform cortex. Stimulations under aminophylline pretreatment more effectively induced SE than those in the absence of aminophylline. Most SE episodes included secondary generalized seizures. Cresyl violet staining indicated neuronal degeneration in CA1 and CA3, 1-2 weeks after the SE. Mild neuronal loss was observed 8 weeks after the SE, although there were no obvious histological changes in the hilus. Immunoreactivity for GluR1, a subunit of the AMPA receptors, was reduced in CA3 and the hilus starting 1 week after SE, indicating a discrepancy between the distributions of neuronal damage and the GluR1 decrement. The present model serves as a useful model of SE. Further improvement of this method will make it an effective tool for understanding the developmental process of temporal lobe epilepsy. en-copyright= kn-copyright= en-aut-name=KoyamaFumihiko en-aut-sei=Koyama en-aut-mei=Fumihiko kn-aut-name=小山文彦 kn-aut-sei=小山 kn-aut-mei=文彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大岡山大学大学院医歯薬学総合研究科 精神神経病態学 en-keyword=けいれん発作重積(status epilepticus) kn-keyword=けいれん発作重積(status epilepticus) en-keyword=深部前梨状葉皮質(deep prepiriform cortex) kn-keyword=深部前梨状葉皮質(deep prepiriform cortex) en-keyword=反復電気刺激(massed electrical stimulations) kn-keyword=反復電気刺激(massed electrical stimulations) en-keyword=AMPA型受容体(AMPA receptors) kn-keyword=AMPA型受容体(AMPA receptors) en-keyword=ラット(rat) kn-keyword=ラット(rat) END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=49 end-page=55 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Mutations and SNPs of human cardiac sodium channel alpha subunit gene (SCN5A) in Japanese patients with Brugada syndrome kn-title=日本人Brugada症候群患者における心筋ナトリウムチャネル遺伝子 (SCN5A) の変異と多型 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Brugada syndrome is an inherited arrhythmogenic disease characterized by right bundle branch block pattern and ST segment elevation, leading to the change of V1 to V3 on electrocardiogram, and an increased risk of sudden cardiac death resulting from ventricular fibrillation. The sodium channel alpha 5 subunit (SCN5A) gene encodes a cardiac voltage-dependent sodium channel, and SCN5A mutations have been reported in Brugada syndrome. However, single nucleotide polymorphisms (SNPs) and gene mutations have not been well investigated in Japanese patients with Brugada syndrome. Methods and Results: The SCN5A gene was examined in 58 patients by using PCR and the ABI 3130xl sequencer, revealing 17 SNP patterns and 13 mutations. Of the 13 mutations, 8 were missense mutations (with amino acid change), 4 were silent mutations (without amino acid change), and one case was a mutation within the splicing junction. Six of the eight missense mutations were novel mutations. Interestingly, we detected an R1664H mutation, which was identified originally in long QT syndrome. Conclusion: We found 13 mutations of the SCN5A gene in 58 patients with Brugada syndrome. The disease may be attributable to some of the mutations and SNPs. en-copyright= kn-copyright= en-aut-name=MiuraDaiji en-aut-sei=Miura en-aut-mei=Daiji kn-aut-name=三浦大志 kn-aut-sei=三浦 kn-aut-mei=大志 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 循環器内科学 en-keyword=不整脈 (arrhythmia) kn-keyword=不整脈 (arrhythmia) en-keyword=Brugada症候群 (Brugada syndrome) kn-keyword=Brugada症候群 (Brugada syndrome) en-keyword=SCN5A (SCN5A) kn-keyword=SCN5A (SCN5A) en-keyword=変異 (mutation) kn-keyword=変異 (mutation) en-keyword=多型 (SNP) kn-keyword=多型 (SNP) END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=57 end-page=60 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of oral morphine for pain relief of peripheral arterial disease kn-title=末梢血行障害による虚血性疼痛に対するモルヒネ内服の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Peripheral arterial disease often causes ischemic ulcers due to impaired blood flow and consequentially induces intractable pain. For these patients, we have recently begun to administer morphine orally. In this study, we retrospectively examined the effects of oral morphine for the relief of pain caused by peripheral arterial disease. Oral morphine was administered to 17 cases of peripheral arterial disease between January, 2004 and February, 2006. The initial dosage was 5 mg or 10 mg, started on an as-needed basis. After the daily dosage of morphine became constant, we divided the dosage into four or six times a day and administered it regularly. With the exception of one case, a small amount of oral morphine, from 20 mg to 70 mg a day, could alleviate patient's pain. Eight cases had side effects such as nausea, constipation or drowsiness. Oral morphine is effective for pain relief of peripheral arterial disease patients. However, now in Japan, oral morphine, which we can prescribe for those patients with insurance, has a shorter duration of action, so we need to administer slow-release morphine. Oral morphine must be administered carefully because many peripheral arterial disease patients have cardiac disease or renal dysfunction as complications. en-copyright= kn-copyright= en-aut-name=NishieHiroyuki en-aut-sei=Nishie en-aut-mei=Hiroyuki kn-aut-name=西江宏行 kn-aut-sei=西江 kn-aut-mei=宏行 aut-affil-num=1 ORCID= en-aut-name=MizobuchiSatoshi en-aut-sei=Mizobuchi en-aut-mei=Satoshi kn-aut-name=溝渕知司 kn-aut-sei=溝渕 kn-aut-mei=知司 aut-affil-num=2 ORCID= en-aut-name=MatsusakiTakashi en-aut-sei=Matsusaki en-aut-mei=Takashi kn-aut-name=松崎孝 kn-aut-sei=松崎 kn-aut-mei=孝 aut-affil-num=3 ORCID= en-aut-name=MiyakeAsako en-aut-sei=Miyake en-aut-mei=Asako kn-aut-name=三宅麻子 kn-aut-sei=三宅 kn-aut-mei=麻子 aut-affil-num=4 ORCID= en-aut-name=KakuRyuji en-aut-sei=Kaku en-aut-mei=Ryuji kn-aut-name=賀来隆治 kn-aut-sei=賀来 kn-aut-mei=隆治 aut-affil-num=5 ORCID= en-aut-name=IshikawaShinichi en-aut-sei=Ishikawa en-aut-mei=Shinichi kn-aut-name=石川慎一 kn-aut-sei=石川 kn-aut-mei=慎一 aut-affil-num=6 ORCID= en-aut-name=SatoKenji en-aut-sei=Sato en-aut-mei=Kenji kn-aut-name=佐藤健治 kn-aut-sei=佐藤 kn-aut-mei=健治 aut-affil-num=7 ORCID= en-aut-name=MatsumiMasaki en-aut-sei=Matsumi en-aut-mei=Masaki kn-aut-name=松三昌樹 kn-aut-sei=松三 kn-aut-mei=昌樹 aut-affil-num=8 ORCID= en-aut-name=KiyoshiMorita en-aut-sei=Kiyoshi en-aut-mei=Morita kn-aut-name=森田潔 kn-aut-sei=森田 kn-aut-mei=潔 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 麻酔科蘇生科 affil-num=2 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 麻酔科蘇生科 affil-num=3 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 麻酔科蘇生科 affil-num=4 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 麻酔科蘇生科 affil-num=5 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 麻酔科蘇生科 affil-num=6 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 麻酔科蘇生科 affil-num=7 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 麻酔科蘇生科 affil-num=8 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 麻酔科蘇生科 affil-num=9 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 麻酔科蘇生科 en-keyword=末梢血行障害 (peripheral arterial disease) kn-keyword=末梢血行障害 (peripheral arterial disease) en-keyword=モルヒネ (oral morphine) kn-keyword=モルヒネ (oral morphine) en-keyword=疼痛管理 (pain management) kn-keyword=疼痛管理 (pain management) en-keyword=虚血性潰瘍 (ischemic ulcer) kn-keyword=虚血性潰瘍 (ischemic ulcer) END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=61 end-page=67 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=I Okayama University Hospital Center for clinical oncology and regional designated cancer-care hospitals kn-title=I がん診療連携拠点病院体制と岡山大学病院腫瘍センター en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TabataMasahiro en-aut-sei=Tabata en-aut-mei=Masahiro kn-aut-name=田端雅弘 kn-aut-sei=田端 kn-aut-mei=雅弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 腫瘍センター en-keyword=がん診療 kn-keyword=がん診療 en-keyword=均てん化 kn-keyword=均てん化 en-keyword=標準治療 kn-keyword=標準治療 en-keyword=腫瘍センター kn-keyword=腫瘍センター END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=69 end-page=72 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=II Cancer registration system kn-title=II がん登録制度 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=GochiAkira en-aut-sei=Gochi en-aut-mei=Akira kn-aut-name=合地明 kn-aut-sei=合地 kn-aut-mei=明 aut-affil-num=1 ORCID= en-aut-name=SenamiHisako en-aut-sei=Senami en-aut-mei=Hisako kn-aut-name=瀬浪尚子 kn-aut-sei=瀬浪 kn-aut-mei=尚子 aut-affil-num=2 ORCID= en-aut-name=OharaNaomi en-aut-sei=Ohara en-aut-mei=Naomi kn-aut-name=尾原直美 kn-aut-sei=尾原 kn-aut-mei=直美 aut-affil-num=3 ORCID= en-aut-name=TabataMasahiro en-aut-sei=Tabata en-aut-mei=Masahiro kn-aut-name=田端雅弘 kn-aut-sei=田端 kn-aut-mei=雅弘 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部病院 医療情報部 affil-num=2 en-affil= kn-affil=岡山大学医学部・歯学部病院 病歴管理室 affil-num=3 en-affil= kn-affil=岡山大学医学部・歯学部病院 病歴管理室 affil-num=4 en-affil= kn-affil=岡山大学医学部・歯学部病院 腫瘍センター en-keyword=院内がん登録 kn-keyword=院内がん登録 en-keyword=地域がん登録 kn-keyword=地域がん登録 en-keyword=case finding kn-keyword=case finding END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=73 end-page=74 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=III Cancer consultation services kn-title=III がん相談支援 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkadaHiroki en-aut-sei=Okada en-aut-mei=Hiroki kn-aut-name=岡田宏基 kn-aut-sei=岡田 kn-aut-mei=宏基 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 総合患者支援センター en-keyword=がん相談支援センター kn-keyword=がん相談支援センター en-keyword=総合患者支援センター kn-keyword=総合患者支援センター en-keyword=がん診療情報提供 kn-keyword=がん診療情報提供 en-keyword=患者図書室での情報提供 kn-keyword=患者図書室での情報提供 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=75 end-page=77 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Blood glucose management in diabetic patients kn-title=糖尿病における血糖管理 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ToneAtsuhito en-aut-sei=Tone en-aut-mei=Atsuhito kn-aut-name=利根淳仁 kn-aut-sei=利根 kn-aut-mei=淳仁 aut-affil-num=1 ORCID= en-aut-name=ShikataKenichi en-aut-sei=Shikata en-aut-mei=Kenichi kn-aut-name=四方賢一 kn-aut-sei=四方 kn-aut-mei=賢一 aut-affil-num=2 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name=槇野博史 kn-aut-sei=槇野 kn-aut-mei=博史 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腎・免疫・内分泌代謝内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腎・免疫・内分泌代謝内科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腎・免疫・内分泌代謝内科学 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=79 end-page=81 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Management of gestational diabetes mellitus kn-title=妊娠糖尿病の取り扱い en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HiramatsuYuji en-aut-sei=Hiramatsu en-aut-mei=Yuji kn-aut-name=平松祐司 kn-aut-sei=平松 kn-aut-mei=祐司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 産科・婦人科学 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=83 end-page=85 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Drug interaction (9. effect of smoking) kn-title=薬物相互作用 (9―喫煙と薬の相互作用) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SagaraHidenori en-aut-sei=Sagara en-aut-mei=Hidenori kn-aut-name=相良英憲 kn-aut-sei=相良 kn-aut-mei=英憲 aut-affil-num=1 ORCID= en-aut-name=KitamuraYoshihisa en-aut-sei=Kitamura en-aut-mei=Yoshihisa kn-aut-name=北村佳久 kn-aut-sei=北村 kn-aut-mei=佳久 aut-affil-num=2 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name=千堂年昭 kn-aut-sei=千堂 kn-aut-mei=年昭 aut-affil-num=3 ORCID= en-aut-name=GomitaYutaka en-aut-sei=Gomita en-aut-mei=Yutaka kn-aut-name=五味田裕 kn-aut-sei=五味田 kn-aut-mei=裕 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　薬剤部 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 医薬管理学 affil-num=3 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　薬剤部 affil-num=4 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　薬剤部 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=87 end-page=89 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Panton-Valentine leukocidin (PVL) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YamasakiOsamu en-aut-sei=Yamasaki en-aut-mei=Osamu kn-aut-name=山崎修 kn-aut-sei=山崎 kn-aut-mei=修 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 皮膚科 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=91 end-page=92 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=<病院紹介>国立病院機構　岩国医療センター en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=齋藤大治 kn-aut-sei=齋藤 kn-aut-mei=大治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=93 end-page=94 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=<病院紹介>神戸赤十字病院 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=守殿貞夫 kn-aut-sei=守殿 kn-aut-mei=貞夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=95 end-page=96 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The winner of the 2006 Academic Award of the Okayama Prefectural Medical Association kn-title=岡山県医師会学術奨励賞受賞を記念して en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KusanoKengo en-aut-sei=Kusano en-aut-mei=Kengo kn-aut-name=草野研吾 kn-aut-sei=草野 kn-aut-mei=研吾 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 循環器内科学 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=97 end-page=101 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 161th Okayama Surgical Society kn-title=<学会抄録>第161回　岡山外科会 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=永瀬瑶典 kn-aut-sei=永瀬 kn-aut-mei=瑶典 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=107 end-page=112 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Bilateral native lung-sparing lobar transplantation kn-title=新しい生体肺移植術式 : 両側自己肺温存部分肺移植術 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SugimotoSeiichiro en-aut-sei=Sugimoto en-aut-mei=Seiichiro kn-aut-name=杉本誠一郎 kn-aut-sei=杉本 kn-aut-mei=誠一郎 aut-affil-num=1 ORCID= en-aut-name=DateHiroshi en-aut-sei=Date en-aut-mei=Hiroshi kn-aut-name=伊達洋至 kn-aut-sei=伊達 kn-aut-mei=洋至 aut-affil-num=2 ORCID= en-aut-name=SugimotoRyujiro en-aut-sei=Sugimoto en-aut-mei=Ryujiro kn-aut-name=杉本龍士郎 kn-aut-sei=杉本 kn-aut-mei=龍士郎 aut-affil-num=3 ORCID= en-aut-name=YamaneMasaomi en-aut-sei=Yamane en-aut-mei=Masaomi kn-aut-name=山根正修 kn-aut-sei=山根 kn-aut-mei=正修 aut-affil-num=4 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name=豊岡伸一 kn-aut-sei=豊岡 kn-aut-mei=伸一 aut-affil-num=5 ORCID= en-aut-name=OtoTakahiro en-aut-sei=Oto en-aut-mei=Takahiro kn-aut-name=大藤剛宏 kn-aut-sei=大藤 kn-aut-mei=剛宏 aut-affil-num=6 ORCID= en-aut-name=AoeMotoi en-aut-sei=Aoe en-aut-mei=Motoi kn-aut-name=青江基 kn-aut-sei=青江 kn-aut-mei=基 aut-affil-num=7 ORCID= en-aut-name=SanoYoshifumi en-aut-sei=Sano en-aut-mei=Yoshifumi kn-aut-name=佐野由文 kn-aut-sei=佐野 kn-aut-mei=由文 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腫瘍・胸部外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腫瘍・胸部外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腫瘍・胸部外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腫瘍・胸部外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腫瘍・胸部外科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腫瘍・胸部外科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腫瘍・胸部外科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腫瘍・胸部外科学 en-keyword=肺移植 kn-keyword=肺移植 en-keyword=生体肺 kn-keyword=生体肺 en-keyword=手術手技 kn-keyword=手術手技 en-keyword=肺機能 kn-keyword=肺機能 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=113 end-page=117 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Accumulating DNA methylation in background mucosa plays a role in esophageal squamous cell carcinogenesis kn-title=食道扁平上皮癌の発癌過程におけるDNAメチル化の役割 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IshiiTatsuhiro en-aut-sei=Ishii en-aut-mei=Tatsuhiro kn-aut-name=石井龍宏 kn-aut-sei=石井 kn-aut-mei=龍宏 aut-affil-num=1 ORCID= en-aut-name=MurakamiJun en-aut-sei=Murakami en-aut-mei=Jun kn-aut-name=村上純 kn-aut-sei=村上 kn-aut-mei=純 aut-affil-num=2 ORCID= en-aut-name=NotoharaKenji en-aut-sei=Notohara en-aut-mei=Kenji kn-aut-name=能登原憲司 kn-aut-sei=能登原 kn-aut-mei=憲司 aut-affil-num=3 ORCID= en-aut-name=SasamotoHiromi en-aut-sei=Sasamoto en-aut-mei=Hiromi kn-aut-name=笹本博美 kn-aut-sei=笹本 kn-aut-mei=博美 aut-affil-num=4 ORCID= en-aut-name=KambaraTakeshi en-aut-sei=Kambara en-aut-mei=Takeshi kn-aut-name=神原健 kn-aut-sei=神原 kn-aut-mei=健 aut-affil-num=5 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name=白川靖博 kn-aut-sei=白川 kn-aut-mei=靖博 aut-affil-num=6 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=7 ORCID= en-aut-name=OuchidaMamoru en-aut-sei=Ouchida en-aut-mei=Mamoru kn-aut-name=大内田守 kn-aut-sei=大内田 kn-aut-mei=守 aut-affil-num=8 ORCID= en-aut-name=ShimizuKenji en-aut-sei=Shimizu en-aut-mei=Kenji kn-aut-name=清水憲二 kn-aut-sei=清水 kn-aut-mei=憲二 aut-affil-num=9 ORCID= en-aut-name=JeremyR. Jass en-aut-sei=Jeremy en-aut-mei=R. Jass kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MatsubaraNagahide en-aut-sei=Matsubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=11 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・腫瘍外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 歯科口腔放射線学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病態探究医学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・腫瘍外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・腫瘍外科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・腫瘍外科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・腫瘍外科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 分子遺伝学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 分子遺伝学 affil-num=10 en-affil= kn-affil=Department of Pathology, McGill University affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・腫瘍外科学 affil-num=12 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・腫瘍外科学 en-keyword=食道扁平上皮癌 kn-keyword=食道扁平上皮癌 en-keyword=プロモーターメチル化 kn-keyword=プロモーターメチル化 en-keyword=p53遺伝子変異 kn-keyword=p53遺伝子変異 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=119 end-page=125 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Molecular biological studies of schizophrenia with a focus on genetics kn-title=統合失調症の分子病態研究について - 遺伝子研究を中心に - en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MoritaYukitaka en-aut-sei=Morita en-aut-mei=Yukitaka kn-aut-name=森田幸孝 kn-aut-sei=森田 kn-aut-mei=幸孝 aut-affil-num=1 ORCID= en-aut-name=UjikeHiroshi en-aut-sei=Ujike en-aut-mei=Hiroshi kn-aut-name=氏家寛 kn-aut-sei=氏家 kn-aut-mei=寛 aut-affil-num=2 ORCID= en-aut-name=KurodaShigetoshi en-aut-sei=Kuroda en-aut-mei=Shigetoshi kn-aut-name=黒田重利 kn-aut-sei=黒田 kn-aut-mei=重利 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 精神神経病態学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 精神神経病態学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 精神神経病態学 en-keyword=統合失調症 kn-keyword=統合失調症 en-keyword=遺伝子研究 kn-keyword=遺伝子研究 en-keyword=多因子遺伝 kn-keyword=多因子遺伝 en-keyword=NMDA仮説 kn-keyword=NMDA仮説 en-keyword=セリンラセメース kn-keyword=セリンラセメース END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=127 end-page=129 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=XAGE-1expression in non-small cell Lung cancer and antibody response in patients kn-title=非小細胞肺癌における癌・精巣抗原XAGE-1の発現と免疫応答の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaKazuhiko en-aut-sei=Nakagawa en-aut-mei=Kazuhiko kn-aut-name=中川和彦 kn-aut-sei=中川 kn-aut-mei=和彦 aut-affil-num=1 ORCID= en-aut-name=NoguchiYuji en-aut-sei=Noguchi en-aut-mei=Yuji kn-aut-name=野口雄司 kn-aut-sei=野口 kn-aut-mei=雄司 aut-affil-num=2 ORCID= en-aut-name=OkumuraHideo en-aut-sei=Okumura en-aut-mei=Hideo kn-aut-name=奥村英雄 kn-aut-sei=奥村 kn-aut-mei=英雄 aut-affil-num=3 ORCID= en-aut-name=SatoShuichiro en-aut-sei=Sato en-aut-mei=Shuichiro kn-aut-name=佐藤修一郎 kn-aut-sei=佐藤 kn-aut-mei=修一郎 aut-affil-num=4 ORCID= en-aut-name=TanakaMotoyuki en-aut-sei=Tanaka en-aut-mei=Motoyuki kn-aut-name=田中志幸 kn-aut-sei=田中 kn-aut-mei=志幸 aut-affil-num=5 ORCID= en-aut-name=ShimonoMichihide en-aut-sei=Shimono en-aut-mei=Michihide kn-aut-name=下野玄英 kn-aut-sei=下野 kn-aut-mei=玄英 aut-affil-num=6 ORCID= en-aut-name=Ali EldibAli Mohamed en-aut-sei=Ali Eldib en-aut-mei=Ali Mohamed kn-aut-name=アリ・エルディブ アリモハメド kn-aut-sei=アリ・エルディブ アリ kn-aut-mei=モハメド aut-affil-num=7 ORCID= en-aut-name=AoeMotoi en-aut-sei=Aoe en-aut-mei=Motoi kn-aut-name=青江基 kn-aut-sei=青江 kn-aut-mei=基 aut-affil-num=8 ORCID= en-aut-name=OnoToshiro en-aut-sei=Ono en-aut-mei=Toshiro kn-aut-name=小野俊朗 kn-aut-sei=小野 kn-aut-mei=俊朗 aut-affil-num=9 ORCID= en-aut-name=UenakaAkiko en-aut-sei=Uenaka en-aut-mei=Akiko kn-aut-name=上中明子 kn-aut-sei=上中 kn-aut-mei=明子 aut-affil-num=10 ORCID= en-aut-name=OharaNobuya en-aut-sei=Ohara en-aut-mei=Nobuya kn-aut-name=大原信哉 kn-aut-sei=大原 kn-aut-mei=信哉 aut-affil-num=11 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name=吉野正 kn-aut-sei=吉野 kn-aut-mei=正 aut-affil-num=12 ORCID= en-aut-name=YamashitaKazuki en-aut-sei=Yamashita en-aut-mei=Kazuki kn-aut-name=山下和城 kn-aut-sei=山下 kn-aut-mei=和城 aut-affil-num=13 ORCID= en-aut-name=TsunodaTsukasa en-aut-sei=Tsunoda en-aut-mei=Tsukasa kn-aut-name=角田司 kn-aut-sei=角田 kn-aut-mei=司 aut-affil-num=14 ORCID= en-aut-name=ShimizuNobuyoshi en-aut-sei=Shimizu en-aut-mei=Nobuyoshi kn-aut-name=清水信義 kn-aut-sei=清水 kn-aut-mei=信義 aut-affil-num=15 ORCID= en-aut-name=NakayamaEiichi en-aut-sei=Nakayama en-aut-mei=Eiichi kn-aut-name=中山睿一 kn-aut-sei=中山 kn-aut-mei=睿一 aut-affil-num=16 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腫瘍・胸部外科学 affil-num=9 en-affil= kn-affil=岡山大学自然生命科学研究支援センター affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病理・病態学 affil-num=12 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病理・病態学 affil-num=13 en-affil= kn-affil=川崎医科大学附属病院 消化器外科学 affil-num=14 en-affil= kn-affil=川崎医科大学附属病院 消化器外科学 affil-num=15 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腫瘍・胸部外科学 affil-num=16 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 免疫学 en-keyword=XAGE-1b kn-keyword=XAGE-1b en-keyword=癌精巣抗原 kn-keyword=癌精巣抗原 en-keyword=非小細胞肺癌 kn-keyword=非小細胞肺癌 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=131 end-page=136 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The theoretical situation of health policy kn-title=医療政策論の現況 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HamadaJun en-aut-sei=Hamada en-aut-mei=Jun kn-aut-name=浜田淳 kn-aut-sei=浜田 kn-aut-mei=淳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 医療政策・管理学 en-keyword=医療制度 kn-keyword=医療制度 en-keyword=社会連帯 kn-keyword=社会連帯 en-keyword=国際比較 kn-keyword=国際比較 en-keyword=社会保険 kn-keyword=社会保険 en-keyword=国民皆保険 kn-keyword=国民皆保険 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=137 end-page=139 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Sonic hedgehog gene therapy for myocardial tissue repair kn-title=ソニック・ヘッジホッグ (Sonic hedgehog) を用いた新たな心筋組織の修復 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KusanoKengo en-aut-sei=Kusano en-aut-mei=Kengo kn-aut-name=草野研吾 kn-aut-sei=草野 kn-aut-mei=研吾 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 循環器内科学 en-keyword=遺伝子治療 kn-keyword=遺伝子治療 en-keyword=再生 kn-keyword=再生 en-keyword=サイトカイン kn-keyword=サイトカイン en-keyword=Morphogen kn-keyword=Morphogen en-keyword=血管新生 kn-keyword=血管新生 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=141 end-page=146 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Accidents in dental treatment: A questionnaire investigation kn-title=歯科医師の就業状況と診療偶発事故 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The relationship between the operational situation of dental treatment and accidents experienced was investigated through questionnaires sent to members of the Kagawa Dental Association. Responses were received from 261 dentists (53% response rate), of whom 113 (43%) had experienced accidents during dental examinations and/or treatment during the past one year. Dentists with a particularly high risk of having accidents were predominantly young males who possessed many medical chairs at their clinic and who daily examined many patients. Those dentists who worked together with two or more colleagues had a lower risk of accidents. These factors should be considered when trying to take preventive measures against accidents during medical examinations and treatment. en-copyright= kn-copyright= en-aut-name=OnoHiroshi en-aut-sei=Ono en-aut-mei=Hiroshi kn-aut-name=小野廣 kn-aut-sei=小野 kn-aut-mei=廣 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部医学科 en-keyword=歯科診療 (dental treatment) kn-keyword=歯科診療 (dental treatment) en-keyword=偶発事故 (accident) kn-keyword=偶発事故 (accident) en-keyword=質問紙調査 (questionnaires) kn-keyword=質問紙調査 (questionnaires) END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=147 end-page=151 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Characterization of the binding of botulinum type B 16S toxin to human intestinal epithelial cells kn-title=ボツリヌスB型16S毒素のヒト腸管上皮細胞への結合活性の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Botulinum neurotoxin produced by Clostridium botulinum type B is a complex of 12S and 16S toxins. 12S toxin consists of a neurotoxin and a nontoxic non-HA (NTNH). The 16S toxin consists of a neurotoxin, an NTNH, and a hemagglutinin (HA). Food-borne botulism is caused by these complex toxins, which are ingested orally and absorbed from the digestive tract across the epithelial barrier lining the gut. Here we show that the type B 16S toxin, but not the 12S toxin or the neurotoxin, binds to the T84 human intestinal epithelial cell line. We also demonstrate that the HA moiety in the 16S toxin mediates the toxin binding to the cells. The carbohydrates containing a galactose moiety inhibited the binding of the 16S toxin to the T84 cells, and neuraminidase treatment of the cells increased the 16S toxin binding. The binding of the 16S toxin to the neuraminidase-treated cells was also inhibited by carbohydrates containing a galactose moiety. These results suggest that the type B 16S toxin binds to human intestinal epithelial cells via the galactose moiety in the carbohydrate chain on the cell surface. en-copyright= kn-copyright= en-aut-name=JinYingji en-aut-sei=Jin en-aut-mei=Yingji kn-aut-name=金英姫 kn-aut-sei=金 kn-aut-mei=英姫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病原細菌学 en-keyword=ボツリヌス毒素　(botulinus toxin) kn-keyword=ボツリヌス毒素　(botulinus toxin) en-keyword=Clostridium botulinum kn-keyword=Clostridium botulinum en-keyword=ボツリヌス中毒 (botulism) kn-keyword=ボツリヌス中毒 (botulism) en-keyword=T84細胞 (T84 cell) kn-keyword=T84細胞 (T84 cell) en-keyword=ガラクトース (galactose) kn-keyword=ガラクトース (galactose) END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=153 end-page=163 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Structural analysis of the factors pertaining to attitudes toward and consciousness of organ donation : Comparison between Japanese and Americans kn-title=臓器提供における態度と意識に関わる諸因子の構造解析 ―日米間の比較を通して en-subtitle= kn-subtitle= en-abstract= kn-abstract=The purpose of this study is to analyze the background factors relating to opinions on organ donation through factorial and structural comparisons between Japanese and Americans. The data were obtained from responses to a questionnaire (371 Japanese and 41 Americans). The main findings are as follows: 1. Most of the factors, ‘a will for organ donation depending on a recipient’, ‘view of remains’, ‘understanding of brain death’ and so on showed significant differences between Japanese and Americans. 2. Japanese had a better understanding of brain death. On the other hand, the ratio of Americans who were willing to donate an organ was higher than that of Japanese. 3. It was revealed that “the approval of organ donation for the third person, not only for one's family” had an impact for having donor card showing the approval for organ donation. Furthermore, as underlying factors generating differences on organ transplant opinions, differences were found among Japanese between “approval of organ transplant” and the attitude assuming that oneself or a member of one's family was the person concerned with organ transplantation. There were also differences between Japanese and Americans on ideas about a view for life and death such as soul existence or view of remains. The argument for transplantation in Japan should consider these structural differences. en-copyright= kn-copyright= en-aut-name=IkeguchiGosen T. en-aut-sei=Ikeguchi en-aut-mei=Gosen T. kn-aut-name=池口豪泉 kn-aut-sei=池口 kn-aut-mei=豪泉 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 法医学 en-keyword=臓器提供 (organ donation) kn-keyword=臓器提供 (organ donation) en-keyword=遺体観 (view of remains) kn-keyword=遺体観 (view of remains) en-keyword=家族 (family) kn-keyword=家族 (family) en-keyword=米国人 (American) kn-keyword=米国人 (American) en-keyword=意識調査 (questionnaire survey) kn-keyword=意識調査 (questionnaire survey) END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=165 end-page=171 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Linkage between stress and metabolic syndrome kn-title=メタボリックシンドロームとストレスとの関連 ―岡山県南部健康づくりセンター利用者での検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=We compared the status of stress with and without metabolic syndrome in Japanese. We used data for 774 men and 1,136 women who had received annual health checkups at Okayama Southern Institute of Health. Status of stress was evaluated using a stress check provided by the Department of Public Health, Nihon University. Metabolic syndrome is defined by new criteria in Japan. Physical stress was significantly higher in men with metabolic syndrome than in men without it. However, the ability of coping with stress in men with metabolic syndrome was significantly higher than that in men without it. Thus a linkage between metabolic syndrome and the status of stress was characteristic in Japanese men. en-copyright= kn-copyright= en-aut-name=KawakitaNorifumi en-aut-sei=Kawakita en-aut-mei=Norifumi kn-aut-name=川北祝史 kn-aut-sei=川北 kn-aut-mei=祝史 aut-affil-num=1 ORCID= en-aut-name=MiyatakeNobuyuki en-aut-sei=Miyatake en-aut-mei=Nobuyuki kn-aut-name=宮武伸行 kn-aut-sei=宮武 kn-aut-mei=伸行 aut-affil-num=2 ORCID= en-aut-name=TakigawaTomoko en-aut-sei=Takigawa en-aut-mei=Tomoko kn-aut-name=瀧川智子 kn-aut-sei=瀧川 kn-aut-mei=智子 aut-affil-num=3 ORCID= en-aut-name=WangDa-Hong en-aut-sei=Wang en-aut-mei=Da-Hong kn-aut-name=汪達紘 kn-aut-sei=汪 kn-aut-mei=達紘 aut-affil-num=4 ORCID= en-aut-name=OginoKeiki en-aut-sei=Ogino en-aut-mei=Keiki kn-aut-name=荻野景規 kn-aut-sei=荻野 kn-aut-mei=景規 aut-affil-num=5 ORCID= en-aut-name=NumataTakeyuki en-aut-sei=Numata en-aut-mei=Takeyuki kn-aut-name=沼田健之 kn-aut-sei=沼田 kn-aut-mei=健之 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部医学科 affil-num=2 en-affil= kn-affil=岡山県南部健康づくりセンター affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 公衆衛生学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 公衆衛生学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 公衆衛生学 affil-num=6 en-affil= kn-affil=岡山県南部健康づくりセンター en-keyword=メタボリックシンドローム (metabolic syndrome) kn-keyword=メタボリックシンドローム (metabolic syndrome) en-keyword=ストレス (stress) kn-keyword=ストレス (stress) en-keyword=チェックリスト (stress check) kn-keyword=チェックリスト (stress check) END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=173 end-page=176 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=I The role of doctors in outpatient cancer chemotherapy kn-title=I 外来化学療法における医師の役割 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=DoiharaHiroyoshi en-aut-sei=Doihara en-aut-mei=Hiroyoshi kn-aut-name=土井原博義 kn-aut-sei=土井原 kn-aut-mei=博義 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 乳腺・内分泌外科 en-keyword=外来化学療法 kn-keyword=外来化学療法 en-keyword=抗がん剤 kn-keyword=抗がん剤 en-keyword=腫瘍センター kn-keyword=腫瘍センター en-keyword=チーム医療 kn-keyword=チーム医療 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=177 end-page=180 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=II The role of nurses in an outpatient cancer chemotherapy center kn-title=II 外来化学療法における看護師の役割 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NishimotoHitomi en-aut-sei=Nishimoto en-aut-mei=Hitomi kn-aut-name=西本仁美 kn-aut-sei=西本 kn-aut-mei=仁美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 看護部 en-keyword=外来化学療法室 kn-keyword=外来化学療法室 en-keyword=看護師の役割 kn-keyword=看護師の役割 en-keyword=チーム医療 kn-keyword=チーム医療 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=181 end-page=186 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=III The role of pharmacists in outpatient chemotherapy kn-title=III 外来化学療法における薬剤師の役割 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FujiwaraSatoko en-aut-sei=Fujiwara en-aut-mei=Satoko kn-aut-name=藤原聡子 kn-aut-sei=藤原 kn-aut-mei=聡子 aut-affil-num=1 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name=千堂年昭 kn-aut-sei=千堂 kn-aut-mei=年昭 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 薬剤部 affil-num=2 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 薬剤部 en-keyword=外来化学療法 kn-keyword=外来化学療法 en-keyword=コーディネート薬剤師 kn-keyword=コーディネート薬剤師 en-keyword=患者自己管理日記帳 kn-keyword=患者自己管理日記帳 en-keyword=副作用モニタリング kn-keyword=副作用モニタリング END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=187 end-page=189 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=IV Chemo-palliative therapy in outpatient and homecare settings: The Okayama University Hospital experience kn-title=IV 外来化学療法と緩和医療・在宅療養支援 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 乳腺・内分泌外科 en-keyword=外来化学療法 kn-keyword=外来化学療法 en-keyword=在宅 kn-keyword=在宅 en-keyword=緩和 kn-keyword=緩和 en-keyword=地域連携 kn-keyword=地域連携 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=191 end-page=194 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Management of dyslipidemia in diabetic patients kn-title=糖尿病患者における脂質管理 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaHitomi en-aut-sei=Kataoka en-aut-mei=Hitomi kn-aut-name=片岡仁美 kn-aut-sei=片岡 kn-aut-mei=仁美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療教育統合開発センター END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=195 end-page=197 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Pulmonary embolism and deep vein thrombosis in the field of Obstetrics and Gynecology kn-title=産婦人科と肺血栓塞栓症/深部静脈血栓症 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HiramatsuYuji en-aut-sei=Hiramatsu en-aut-mei=Yuji kn-aut-name=平松祐司 kn-aut-sei=平松 kn-aut-mei=祐司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 産科・婦人科学 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=199 end-page=203 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Drug interaction (10. combination with immunosuppressive drugs) kn-title=薬物相互作用 (10―免疫抑制薬の薬物相互作用) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SatoTomoaki en-aut-sei=Sato en-aut-mei=Tomoaki kn-aut-name=佐藤智昭 kn-aut-sei=佐藤 kn-aut-mei=智昭 aut-affil-num=1 ORCID= en-aut-name=UeshimaSatoshi en-aut-sei=Ueshima en-aut-mei=Satoshi kn-aut-name=上島智 kn-aut-sei=上島 kn-aut-mei=智 aut-affil-num=2 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name=千堂年昭 kn-aut-sei=千堂 kn-aut-mei=年昭 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 薬剤部 affil-num=2 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 薬剤部 affil-num=3 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 薬剤部 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=205 end-page=207 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Hepatitis B virus genotype/subgenotype kn-title=B型肝炎ウイルスGenotype/subgenotype en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HigashiToshihiro en-aut-sei=Higashi en-aut-mei=Toshihiro kn-aut-name=東俊宏 kn-aut-sei=東 kn-aut-mei=俊宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山市立市民病院 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=209 end-page=210 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=<病院紹介>特定医療法人社団同仁会　金光病院 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=難波義夫 kn-aut-sei=難波 kn-aut-mei=義夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=211 end-page=212 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=<病院紹介>医療法人 青山会　西条中央病院 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=村下純二 kn-aut-sei=村下 kn-aut-mei=純二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=213 end-page=214 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Introduction of the winner of the Japanese Association of Criminology Prize for 2006 kn-title=<会員紹介>日本犯罪学会賞を受賞して en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IshizuHideo en-aut-sei=Ishizu en-aut-mei=Hideo kn-aut-name=石津日出雄 kn-aut-sei=石津 kn-aut-mei=日出雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=川崎医療福祉大学 医療福祉学部 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=215 end-page=216 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The winner of the 2006 Academic Award of the Okayama Prefectural Medical Association kn-title=<会員紹介>岡山県医師会学術奨励賞 (平成18年) を受賞して en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name=大塚文男 kn-aut-sei=大塚 kn-aut-mei=文男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腎・免疫・内分泌代謝内科学 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=2 article-no= start-page=217 end-page=221 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070903 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 106th general assembly of the Okayama Medical Association kn-title=<学会抄録>第106回 岡山医学会総会 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山医学会 kn-aut-sei=岡山医学会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=223 end-page=227 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Increased expression of receptor for advanced glycation end products by synovial tissue macrophages in rheumatoid arthritis kn-title=関節リウマチの滑膜マクロファージにおける最終糖化産物受容体 (RAGE) の発現亢進 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SunahoriKatsue en-aut-sei=Sunahori en-aut-mei=Katsue kn-aut-name=砂堀克枝 kn-aut-sei=砂堀 kn-aut-mei=克枝 aut-affil-num=1 ORCID= en-aut-name=YamamuraMasahiro en-aut-sei=Yamamura en-aut-mei=Masahiro kn-aut-name=山村昌弘 kn-aut-sei=山村 kn-aut-mei=昌弘 aut-affil-num=2 ORCID= en-aut-name=YamanaJiro en-aut-sei=Yamana en-aut-mei=Jiro kn-aut-name=山名二郎 kn-aut-sei=山名 kn-aut-mei=二郎 aut-affil-num=3 ORCID= en-aut-name=TakasugiKoji en-aut-sei=Takasugi en-aut-mei=Koji kn-aut-name=高杉幸司 kn-aut-sei=高杉 kn-aut-mei=幸司 aut-affil-num=4 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name=槇野博史 kn-aut-sei=槇野 kn-aut-mei=博史 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腎・免疫・内分泌代謝内科学 affil-num=2 en-affil= kn-affil=愛知医科大学 リウマチ科 affil-num=3 en-affil= kn-affil=ハーバード大学ベスイスラエル病院 リウマチ科 affil-num=4 en-affil= kn-affil=ハーバード大学ベスイスラエル病院 リウマチ科 affil-num=5 en-affil= kn-affil=ハーバード大学ベスイスラエル病院 リウマチ科 en-keyword=関節リウマチ (RA) kn-keyword=関節リウマチ (RA) en-keyword=最終糖化産物受容体 (RAGE) kn-keyword=最終糖化産物受容体 (RAGE) en-keyword=マクロファージ kn-keyword=マクロファージ en-keyword=HMGB-1 kn-keyword=HMGB-1 en-keyword=S100A12 kn-keyword=S100A12 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=229 end-page=234 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Adenoviral p53 gene therapy for lung cancer kn-title=p53 遺伝子を発現するアデノウイルスベクターを用いた肺癌の遺伝子治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To determine the feasibility, safety, humoral immune response, and biological activity of multiple intratumoral injections of Ad5CMV-p53, and to characterize the pharmacokinetics of Ad5CMV-p53 in patients with advanced non-small cell lung cancer (NSCLC). Fifteen patients with histologically confirmed NSCLC and p53 mutations were enrolled into this phase I trial. Nine patients received escalating dose levels of Ad5CMV-p53 (1 × 109 to 1 × 1011 plaque-forming units[PFU]) as monotherapy once every 4 weeks. Six patients were treated on a 28-day schedule with Ad5CMV-p53 in combination with intravenous administration of cisplatin (80 mg/m2). Patients were monitored for toxicity, vector distribution, antibody formation, and tumor response. Fifteen patients received a total of 63 intratumoral injections of Ad5CMV-p53 without dose-limiting toxicity. The most common treatment-related toxicity was a transient fever. Specific p53 transgene expression was detected using reverse-transcriptase polymerase chain reaction in biopsied tumor tissues throughout the period of treatment despite of the presence of neutralizing anti-adenovirus antibody. Distribution studies revealed that the vector was detected in the gargle and plasma, but rarely in the urine. Thirteen of 15 patients were assessable for efficacy; one patient had a partial response (squamous cell carcinoma at the carina), 10 patients had stable disease, with three lasting ≥9 months, and 2 patients had progressive disease. Multiple courses of intratumoral Ad5CMV-p53 injection alone or in combination with intravenous administration of cisplatin were feasible and well tolerated in advanced NSCLC patients, and appeared to provide clinical benefit. en-copyright= kn-copyright= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=1 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 遺伝子・細胞治療センター affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・腫瘍外科学 en-keyword=p53 遺伝子 kn-keyword=p53 遺伝子 en-keyword=アデノウイルスベクター (adenovirus vector) kn-keyword=アデノウイルスベクター (adenovirus vector) en-keyword=肺癌 (lung cancer) kn-keyword=肺癌 (lung cancer) en-keyword=臨床試験 (clinical trial) kn-keyword=臨床試験 (clinical trial) END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=235 end-page=239 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Quinone formation as a common neurotoxic factor in dopaminergic neurotoxicity induced by an excess amount of cytosolic dopamine kn-title=小胞外過剰ドパミンによるドパミン神経障害における共通因子としてのキノン体生成 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MiyazakiIkuko en-aut-sei=Miyazaki en-aut-mei=Ikuko kn-aut-name=宮崎育子 kn-aut-sei=宮崎 kn-aut-mei=育子 aut-affil-num=1 ORCID= en-aut-name=AsanumaMasato en-aut-sei=Asanuma en-aut-mei=Masato kn-aut-name=浅沼幹人 kn-aut-sei=浅沼 kn-aut-mei=幹人 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Francisco J.Diaz-Corrales kn-aut-sei=Francisco J. kn-aut-mei=Diaz-Corrales aut-affil-num=3 ORCID= en-aut-name=MiyoshiKo en-aut-sei=Miyoshi en-aut-mei=Ko kn-aut-name=三好耕 kn-aut-sei=三好 kn-aut-mei=耕 aut-affil-num=4 ORCID= en-aut-name=OgawaNorio en-aut-sei=Ogawa en-aut-mei=Norio kn-aut-name=小川紀雄 kn-aut-sei=小川 kn-aut-mei=紀雄 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 神経情報学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 神経情報学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 神経情報学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 神経情報学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 神経情報学 en-keyword=ドパミンキノン kn-keyword=ドパミンキノン en-keyword=パーキンソン病 kn-keyword=パーキンソン病 en-keyword=メタンフェタミン kn-keyword=メタンフェタミン en-keyword=キノン還元酵素 kn-keyword=キノン還元酵素 en-keyword=チロシナーゼ kn-keyword=チロシナーゼ END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=241 end-page=246 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Promotion of clinical trial as medical policy and the improvement of medical care kn-title=医療政策としての治験の推進と医療の質の向上 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=DoiHiroyuki en-aut-sei=Doi en-aut-mei=Hiroyuki kn-aut-name=土居弘幸 kn-aut-sei=土居 kn-aut-mei=弘幸 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 衛生学・予防医学 en-keyword=治験 kn-keyword=治験 en-keyword=医療の質 kn-keyword=医療の質 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=247 end-page=251 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Impaired coronary capillary hemodynamics with decreased glycocalyx thickness and irregular inner wall remodeling in right ventricle of pulmonary hypertensive rats kn-title=肺高血圧ラット右室冠毛細管における内皮グリコカリックスの減少を伴う内壁リモデリングとヘモダイナミクスの変化 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We hypothesized that coronary capillary function is impaired with a decreased glycocalyx layer and uneven inner wall remodeling in right ventricles that are hypertrophied due to pulmonary hypertension (PH). Five-week-old male Sprague-Dawley rats were divided into 2 groups (PH: n=25, control: n=27). In the PH group, Monocrotaline (60 mg/kg SC) was administrated at 5 weeks. Coronary capillary hemodynamics was visualized in vivo at 8 weeks of age using our high-resolution intravital videomicrosopy, and RBC velocities in RV capillaries were evaluated, along with capillary diameters. Configuration of the capillary cast was assessed by a confocal laser scanning microscope. The thickness of the glycocalyx on the capillary endothelial surface was evaluated with Alcian blue 8GX by electron microscopy. RV systolic pressure increased in PH (by 142%, p<0.01). The diameters of capillaries were uneven in PH (coefficient of variation of diameters along capillary trees; 24±8% vs. 11±3%, p<0.05). The thickness of the glycocalyx in PH was less than half that of control (0.20±0.05 vs. 0.45±0.14 μm, p<0.05). RBC velocity was decreased in PH (820±110 vs. 1,100±230 μm/sec, p<0.05). The capillary flow reduction in PH may be closely related to the changes in the glycocalyx and vessel irregularity, resulting in insufficient oxygen supply to the heart. en-copyright= kn-copyright= en-aut-name=KajiyaMasahito en-aut-sei=Kajiya en-aut-mei=Masahito kn-aut-name=梶谷昌史 kn-aut-sei=梶谷 kn-aut-mei=昌史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 循環器内科学 en-keyword=モノクロタリン (monocrotaline) kn-keyword=モノクロタリン (monocrotaline) en-keyword=肺高血圧 (pulmonary hypertension) kn-keyword=肺高血圧 (pulmonary hypertension) en-keyword=冠毛細管 (coronary capillary) kn-keyword=冠毛細管 (coronary capillary) en-keyword=グリコカリックス (glycocalyx) kn-keyword=グリコカリックス (glycocalyx) en-keyword=リモデリング (remodeling) kn-keyword=リモデリング (remodeling) END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=253 end-page=260 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Apoe+/-ldlr+/- mice as a useful model to evaluate accelerated atherogenesis by Helicobacter pylori infection kn-title=ヘリコバクター・ピロリ感染による動脈硬化促進検討モデルとしてのapoe+/-ldlr+/-マウスの有用性 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Atherosclerosis is closely related to chronic infection. In the present study, we evaluated atherogenesis by gastric infection with Helicobacter pylori (H. pylori) in atherosclerosis-prone apoe+/-ldlr+/- mice. Six- week- old male apoe+/-ldlr+/- mice infected by H. pylori and apoe+/-ldlr+/- control mice were fed with a high cholesterol diet (1%). Eight weeks after the confirmation of infection, the extent of atherosclerosis, anti heat shock protein 60 of H. pylori (Hp-HSP60) serum titers, and the cellular immune responses against Hp-HSP60 were evaluated. Atherosclerosis was promoted by a Th1-mediated reaction against Hp-HSP60, accompanied by production of IFN-γ and IL-12, and mRNA expression of T-bet in the H. pylori -infected apoe+/-ldlr+/- mice. The over-expressed of HSP60 in stressed endothelial cells could be cross-recognized by T cells against Hp-HSP60 and contributed to the atherosclerosis. This mouse model would be useful for analyzing immunological mechanisms of atherogenesis. en-copyright= kn-copyright= en-aut-name=CuiJinhua en-aut-sei=Cui en-aut-mei=Jinhua kn-aut-name=崔錦花 kn-aut-sei=崔 kn-aut-mei=錦花 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病原細菌学 en-keyword=動脈硬化 (atherosclerosis) kn-keyword=動脈硬化 (atherosclerosis) en-keyword=ヘリコバクター・ピロリ (Helicobacter pylori) kn-keyword=ヘリコバクター・ピロリ (Helicobacter pylori) en-keyword=熱ストレスタンパク60 (heat shock protein 60) kn-keyword=熱ストレスタンパク60 (heat shock protein 60) en-keyword=Tリンパ球 (T-lymphocytes) kn-keyword=Tリンパ球 (T-lymphocytes) en-keyword=apoe+/-ldlr+/-ヘテロダブルノックアウトマウス (apoe+/-ldlr+/- mice) kn-keyword=apoe+/-ldlr+/-ヘテロダブルノックアウトマウス (apoe+/-ldlr+/- mice) END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=261 end-page=265 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Eosinophilic gastroenteritis with ascites and diffuse intestinal wall thickening kn-title=腹水貯留と広範囲な腸管壁の肥厚を伴う好酸球性胃腸炎の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 60-year-old woman was admitted to our hospital with abdominal pain and diarrhea. Examination revealed eosinophilia (white blood count, 24,900/ml; eosinophils, 79.9%) and an elevated immunoglobulin E level. Abdominal computed tomography showed fluid collection and diffuse intestinal wall thickening, and biopsy specimens from the stomach, duodenum and colon showed eosinophil infiltration. We diagnosed the patient with eosinophilic gastroenteritis, and started treatment with steroid hormones (predonisolone, 40 mg/day perorally). The patient's symptoms and eosinophilia improved dramatically and she was discharged. Eosinophilic gastroenteritis is an inflammatory disease characterized by eosinophil infiltration into the gastrointestinal tract. It usually involves the stomach and small intestine, but may also involve the entire whole gastrointestinal tract. Although ascites sometimes complicates this disease, massive ascites, as in our patient, is rare. Here we report a case of eosinophilic gastroenteritis with massive ascites and diffuse intestinal wall thickening. Steroid hormones are an effective treatment for this disease, and early diagnosis and the administration of steroid hormones are essential. en-copyright= kn-copyright= en-aut-name=TachibanaHiromi en-aut-sei=Tachibana en-aut-mei=Hiromi kn-aut-name=橘洋美 kn-aut-sei=橘 kn-aut-mei=洋美 aut-affil-num=1 ORCID= en-aut-name=OgawaDaisuke en-aut-sei=Ogawa en-aut-mei=Daisuke kn-aut-name=小川大輔 kn-aut-sei=小川 kn-aut-mei=大輔 aut-affil-num=2 ORCID= en-aut-name=KaharaKenji en-aut-sei=Kahara en-aut-mei=Kenji kn-aut-name=加原健治 kn-aut-sei=加原 kn-aut-mei=健治 aut-affil-num=3 ORCID= en-aut-name=FujiiSouichiro en-aut-sei=Fujii en-aut-mei=Souichiro kn-aut-name=藤井総一郎 kn-aut-sei=藤井 kn-aut-mei=総一郎 aut-affil-num=4 ORCID= en-aut-name=HayakawaNobuhiko en-aut-sei=Hayakawa en-aut-mei=Nobuhiko kn-aut-name=早川信彦 kn-aut-sei=早川 kn-aut-mei=信彦 aut-affil-num=5 ORCID= en-aut-name=TsurumiTetsuya en-aut-sei=Tsurumi en-aut-mei=Tetsuya kn-aut-name=鶴見哲也 kn-aut-sei=鶴見 kn-aut-mei=哲也 aut-affil-num=6 ORCID= en-aut-name=MiyakeTakayoshi en-aut-sei=Miyake en-aut-mei=Takayoshi kn-aut-name=三宅孝佳 kn-aut-sei=三宅 kn-aut-mei=孝佳 aut-affil-num=7 ORCID= en-aut-name=KunitomoTadayoshi en-aut-sei=Kunitomo en-aut-mei=Tadayoshi kn-aut-name=國友忠義 kn-aut-sei=國友 kn-aut-mei=忠義 aut-affil-num=8 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=総合病院岡山赤十字病院 内科 affil-num=2 en-affil= kn-affil=総合病院岡山赤十字病院 内科 affil-num=3 en-affil= kn-affil=総合病院岡山赤十字病院 内科 affil-num=4 en-affil= kn-affil=総合病院岡山赤十字病院 内科 affil-num=5 en-affil= kn-affil=総合病院岡山赤十字病院 内科 affil-num=6 en-affil= kn-affil=総合病院岡山赤十字病院 内科 affil-num=7 en-affil= kn-affil=総合病院岡山赤十字病院 病理科 affil-num=8 en-affil= kn-affil=総合病院岡山赤十字病院 病理科 affil-num=9 en-affil= kn-affil=総合病院岡山赤十字病院 病理科 en-keyword=好酸球性胃腸炎 (Eosinophilic gastroenteritis) kn-keyword=好酸球性胃腸炎 (Eosinophilic gastroenteritis) en-keyword=アレルギー (Allergy) kn-keyword=アレルギー (Allergy) en-keyword=腹水 (Ascites) kn-keyword=腹水 (Ascites) en-keyword=ステロイドホルモン (Steroid hormone) kn-keyword=ステロイドホルモン (Steroid hormone) END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=267 end-page=272 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A collaborative approach to head and neck carcinoma for oral surgeons, head and neck surgeons, and plastic surgeons: The role of oral surgeons in two cases kn-title=頭頸部癌における耳鼻咽喉科, 形成外科, 口腔外科3科合同手術の意義 : 2症例における口腔外科の役割を中心に en-subtitle= kn-subtitle= en-abstract= kn-abstract=There is a medical team approach used in many hospitals for oral cancer patients. The members are head & neck surgeons and plastic surgeons, or oral surgeons and plastic surgeons. However, in Japan, it is very difficult for oral surgeons to cooperate with head & neck surgeons, except in the case of extractions and oral health care, because both surgeons treat oral carcinomas and there is therefore a conflict in their scope of practice. We believe it desirable for head & neck surgeons to treat oral cancer patients with tumors extending to other regions, and oral surgeons should be in charge of occlusion in head and neck carcinomas. We treated two patients with oral carcinomas in collaboration with head and neck surgeons and plastic surgeons, with head & neck surgeons resecting the tumors, plastic surgeons reconstructing, and oral surgeons (dentists) taking charge of the occlusion for patients in the operating room. This collaboration resulted in patients having good position of the temporomandibular joint and occlusions after the operation. We therefore conclude that this collaborative team approach may be of benefit to the patients. en-copyright= kn-copyright= en-aut-name=MizukawaNobuyoshi en-aut-sei=Mizukawa en-aut-mei=Nobuyoshi kn-aut-name=水川展吉 kn-aut-sei=水川 kn-aut-mei=展吉 aut-affil-num=1 ORCID= en-aut-name=TominagaSusumu en-aut-sei=Tominaga en-aut-mei=Susumu kn-aut-name=冨永進 kn-aut-sei=冨永 kn-aut-mei=進 aut-affil-num=2 ORCID= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name=木股敬裕 kn-aut-sei=木股 kn-aut-mei=敬裕 aut-affil-num=3 ORCID= en-aut-name=OnodaTomoo en-aut-sei=Onoda en-aut-mei=Tomoo kn-aut-name=小野田友男 kn-aut-sei=小野田 kn-aut-mei=友男 aut-affil-num=4 ORCID= en-aut-name=NomiyaShigenobu en-aut-sei=Nomiya en-aut-mei=Shigenobu kn-aut-name=野宮重信 kn-aut-sei=野宮 kn-aut-mei=重信 aut-affil-num=5 ORCID= en-aut-name=SugiyamaNarushi en-aut-sei=Sugiyama en-aut-mei=Narushi kn-aut-name=杉山成史 kn-aut-sei=杉山 kn-aut-mei=成史 aut-affil-num=6 ORCID= en-aut-name=KawamotoTomoaki en-aut-sei=Kawamoto en-aut-mei=Tomoaki kn-aut-name=川本知明 kn-aut-sei=川本 kn-aut-mei=知明 aut-affil-num=7 ORCID= en-aut-name=YamachikaEiki en-aut-sei=Yamachika en-aut-mei=Eiki kn-aut-name=山近英樹 kn-aut-sei=山近 kn-aut-mei=英樹 aut-affil-num=8 ORCID= en-aut-name=UenoTakaaki en-aut-sei=Ueno en-aut-mei=Takaaki kn-aut-name=植野高章 kn-aut-sei=植野 kn-aut-mei=高章 aut-affil-num=9 ORCID= en-aut-name=TakagiShin en-aut-sei=Takagi en-aut-mei=Shin kn-aut-name=高木慎 kn-aut-sei=高木 kn-aut-mei=慎 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 口腔外科再建系 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 耳鼻咽喉・頭頸部外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 形成再建外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 耳鼻咽喉・頭頸部外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 耳鼻咽喉・頭頸部外科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 形成再建外科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 歯顎口腔機能再建外科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 歯顎口腔機能再建外科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 歯顎口腔機能再建外科学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 歯顎口腔機能再建外科学 en-keyword=チーム医療 (medical team approach) kn-keyword=チーム医療 (medical team approach) en-keyword=頭頸部癌 (head and neck carcinoma) kn-keyword=頭頸部癌 (head and neck carcinoma) END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=273 end-page=283 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=I The diagnosis of and therapy for breast cancer kn-title=I 乳がんの診断と治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=DoiharaHiroyoshi en-aut-sei=Doihara en-aut-mei=Hiroyoshi kn-aut-name=土井原博義 kn-aut-sei=土井原 kn-aut-mei=博義 aut-affil-num=1 ORCID= en-aut-name=TairaNaruto en-aut-sei=Taira en-aut-mei=Naruto kn-aut-name=平成人 kn-aut-sei=平 kn-aut-mei=成人 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 乳腺・内分泌外科 affil-num=2 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 乳腺・内分泌外科 en-keyword=乳がん kn-keyword=乳がん en-keyword=診断 kn-keyword=診断 en-keyword=手術 kn-keyword=手術 en-keyword=薬物療法 kn-keyword=薬物療法 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=285 end-page=292 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=II Standard treatment for advanced lung cancer kn-title=II 肺癌の内科的治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KiuraKatsuyuki en-aut-sei=Kiura en-aut-mei=Katsuyuki kn-aut-name=木浦勝行 kn-aut-sei=木浦 kn-aut-mei=勝行 aut-affil-num=1 ORCID= en-aut-name=TakigawaNagio en-aut-sei=Takigawa en-aut-mei=Nagio kn-aut-name=瀧川奈義夫 kn-aut-sei=瀧川 kn-aut-mei=奈義夫 aut-affil-num=2 ORCID= en-aut-name=OzeIsao en-aut-sei=Oze en-aut-mei=Isao kn-aut-name=尾瀬功 kn-aut-sei=尾瀬 kn-aut-mei=功 aut-affil-num=3 ORCID= en-aut-name=YasugiMasayuki en-aut-sei=Yasugi en-aut-mei=Masayuki kn-aut-name=八杉昌幸 kn-aut-sei=八杉 kn-aut-mei=昌幸 aut-affil-num=4 ORCID= en-aut-name=OchiNobuaki en-aut-sei=Ochi en-aut-mei=Nobuaki kn-aut-name=越智宣昭 kn-aut-sei=越智 kn-aut-mei=宣昭 aut-affil-num=5 ORCID= en-aut-name=HaradaDaijiro en-aut-sei=Harada en-aut-mei=Daijiro kn-aut-name=原田大二郎 kn-aut-sei=原田 kn-aut-mei=大二郎 aut-affil-num=6 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name=谷本光音 kn-aut-sei=谷本 kn-aut-mei=光音 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 en-keyword=放射線化学療法 kn-keyword=放射線化学療法 en-keyword=分子標的治療 kn-keyword=分子標的治療 en-keyword=血管新生阻害薬 kn-keyword=血管新生阻害薬 en-keyword=受容体チロシンキナーゼ阻害薬 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dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=IV Standard medical treatment of gastrointestinal carcinoma kn-title=IV 消化器癌の内科的標準治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YagiToru en-aut-sei=Yagi en-aut-mei=Toru kn-aut-name=八木覚 kn-aut-sei=八木 kn-aut-mei=覚 aut-affil-num=1 ORCID= en-aut-name=KawaharaYoshiro en-aut-sei=Kawahara en-aut-mei=Yoshiro kn-aut-name=河原祥朗 kn-aut-sei=河原 kn-aut-mei=祥朗 aut-affil-num=2 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=3 ORCID= en-aut-name=TakemotoKoji en-aut-sei=Takemoto en-aut-mei=Koji kn-aut-name=竹本浩二 kn-aut-sei=竹本 kn-aut-mei=浩二 aut-affil-num=4 ORCID= en-aut-name=KatoJun en-aut-sei=Kato en-aut-mei=Jun kn-aut-name=加藤順 kn-aut-sei=加藤 kn-aut-mei=順 aut-affil-num=5 ORCID= en-aut-name=KobayashiYoshiyuki en-aut-sei=Kobayashi en-aut-mei=Yoshiyuki kn-aut-name=小林功幸 kn-aut-sei=小林 kn-aut-mei=功幸 aut-affil-num=6 ORCID= en-aut-name=KawamotoHirofumi en-aut-sei=Kawamoto en-aut-mei=Hirofumi kn-aut-name=河本博文 kn-aut-sei=河本 kn-aut-mei=博文 aut-affil-num=7 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name=山本和秀 kn-aut-sei=山本 kn-aut-mei=和秀 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓・感染症内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓・感染症内科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓・感染症内科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓・感染症内科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓・感染症内科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓・感染症内科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓・感染症内科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓・感染症内科学 en-keyword=消化器癌 kn-keyword=消化器癌 en-keyword=内科治療 kn-keyword=内科治療 en-keyword=化学療法 kn-keyword=化学療法 en-keyword=内視鏡治療 kn-keyword=内視鏡治療 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=311 end-page=313 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Control of blood pressure in diabetic patients kn-title=糖尿病患者における血圧管理 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SasakiMotofumi en-aut-sei=Sasaki en-aut-mei=Motofumi kn-aut-name=佐々木基史 kn-aut-sei=佐々木 kn-aut-mei=基史 aut-affil-num=1 ORCID= en-aut-name=ShikataKenichi en-aut-sei=Shikata en-aut-mei=Kenichi kn-aut-name=四方賢一 kn-aut-sei=四方 kn-aut-mei=賢一 aut-affil-num=2 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name=槇野博史 kn-aut-sei=槇野 kn-aut-mei=博史 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腎・免疫・内分泌代謝内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腎・免疫・内分泌代謝内科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 腎・免疫・内分泌代謝内科学 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=315 end-page=317 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical guidelines for the administration of low-dose oral contraceptives kn-title=低用量経口避妊薬の使用に関するガイドライン en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KamadaYasuhiko en-aut-sei=Kamada en-aut-mei=Yasuhiko kn-aut-name=鎌田泰彦 kn-aut-sei=鎌田 kn-aut-mei=泰彦 aut-affil-num=1 ORCID= en-aut-name=HiramatsuYuji en-aut-sei=Hiramatsu en-aut-mei=Yuji kn-aut-name=平松祐司 kn-aut-sei=平松 kn-aut-mei=祐司 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 産科・婦人科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 産科・婦人科学 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=319 end-page=322 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Drug interaction (11. combination with the anticancer agents) kn-title=薬物相互作用 (11―抗がん剤の薬物相互作用) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MatsunagaHisashi en-aut-sei=Matsunaga en-aut-mei=Hisashi kn-aut-name=松永尚 kn-aut-sei=松永 kn-aut-mei=尚 aut-affil-num=1 ORCID= en-aut-name=SendoToshiaki en-aut-sei=Sendo en-aut-mei=Toshiaki kn-aut-name=千堂年昭 kn-aut-sei=千堂 kn-aut-mei=年昭 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 薬剤部 affil-num=2 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 薬剤部 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=323 end-page=325 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Epigenetics kn-title=エピジェネティクス en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakataKatsuyoshi en-aut-sei=Takata en-aut-mei=Katsuyoshi kn-aut-name=高田尚良 kn-aut-sei=高田 kn-aut-mei=尚良 aut-affil-num=1 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name=吉野正 kn-aut-sei=吉野 kn-aut-mei=正 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病理・病態学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病理・病態学 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=327 end-page=328 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=<病院紹介>医療法人聖医会　佐用中央病院 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤綱徹也 kn-aut-sei=藤綱 kn-aut-mei=徹也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=329 end-page=330 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=<病院紹介>医療法人正寿会　秋山記念病院 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=秋山実男 kn-aut-sei=秋山 kn-aut-mei=実男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=331 end-page=333 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A memorial note upon receiving the Shiga Kiyoshi-Hata Sahachiro Memorial Award kn-title=<会員紹介>志賀潔・秦佐八郎記念賞を受賞して en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KumonHiromi en-aut-sei=Kumon en-aut-mei=Hiromi kn-aut-name=公文裕巳 kn-aut-sei=公文 kn-aut-mei=裕巳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 泌尿器病態学 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=335 end-page=342 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 162th Okayama Surgical Society kn-title=<学会抄録>第162回 岡山外科会 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=種本和雄 kn-aut-sei=種本 kn-aut-mei=和雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=2 article-no= start-page=129 end-page=133 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Novel protein transduction method for cerebral arteries using 11R kn-title=11Rを用いた脳血管に対する新しい蛋白質導入法 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OgawaTomoyuki en-aut-sei=Ogawa en-aut-mei=Tomoyuki kn-aut-name=小川智之 kn-aut-sei=小川 kn-aut-mei=智之 aut-affil-num=1 ORCID= en-aut-name=OnoShigeki en-aut-sei=Ono en-aut-mei=Shigeki kn-aut-name=小野成紀 kn-aut-sei=小野 kn-aut-mei=成紀 aut-affil-num=2 ORCID= en-aut-name=IchikawaTomotsugu en-aut-sei=Ichikawa en-aut-mei=Tomotsugu kn-aut-name=市川智継 kn-aut-sei=市川 kn-aut-mei=智継 aut-affil-num=3 ORCID= en-aut-name=ArimitsuSeiji en-aut-sei=Arimitsu en-aut-mei=Seiji kn-aut-name=有光帥二 kn-aut-sei=有光 kn-aut-mei=帥二 aut-affil-num=4 ORCID= en-aut-name=OnodaKeisuke en-aut-sei=Onoda en-aut-mei=Keisuke kn-aut-name=小野田惠介 kn-aut-sei=小野田 kn-aut-mei=惠介 aut-affil-num=5 ORCID= en-aut-name=TokunagaKoji en-aut-sei=Tokunaga en-aut-mei=Koji kn-aut-name=徳永浩司 kn-aut-sei=徳永 kn-aut-mei=浩司 aut-affil-num=6 ORCID= en-aut-name=SugiuKenji en-aut-sei=Sugiu en-aut-mei=Kenji kn-aut-name=杉生憲志 kn-aut-sei=杉生 kn-aut-mei=憲志 aut-affil-num=7 ORCID= en-aut-name=TomizawaKazuhito en-aut-sei=Tomizawa en-aut-mei=Kazuhito kn-aut-name=富澤一仁 kn-aut-sei=富澤 kn-aut-mei=一仁 aut-affil-num=8 ORCID= en-aut-name=MatsuiHideki en-aut-sei=Matsui en-aut-mei=Hideki kn-aut-name=松井秀樹 kn-aut-sei=松井 kn-aut-mei=秀樹 aut-affil-num=9 ORCID= en-aut-name=DateIsao en-aut-sei=Date en-aut-mei=Isao kn-aut-name=伊達勲 kn-aut-sei=伊達 kn-aut-mei=勲 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科 affil-num=8 en-affil= kn-affil=熊本大学大学院医学薬学研究部　分子生理学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科 en-keyword=cerebral vasospasm kn-keyword=cerebral vasospasm en-keyword=11R kn-keyword=11R en-keyword=protein transduction method kn-keyword=protein transduction method END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=2 article-no= start-page=135 end-page=141 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Adenovirus-mediated REIC/Dkk-3 gene therapy for prostate tumor in vivo and in vitro kn-title=アデノウイルスベクターを用いた REIC/Dkk-3遺伝子導入による前立腺癌の転移抑制効果について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=EdamuraKohei en-aut-sei=Edamura en-aut-mei=Kohei kn-aut-name=枝村康平 kn-aut-sei=枝村 kn-aut-mei=康平 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 en-keyword=Dkk-3 kn-keyword=Dkk-3 en-keyword=REIC kn-keyword=REIC en-keyword=前立腺癌 kn-keyword=前立腺癌 en-keyword=転移 kn-keyword=転移 END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=2 article-no= start-page=143 end-page=147 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Macrophage scavenger receptor-A--deficient mice are resistant to diabetic nephropathy through amelioration of microinflammation kn-title=マクロファージスカベンジャー受容体（SR-A）は炎症を制御することにより糖尿病性腎症を抑制する en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KataokaHitomi en-aut-sei=Kataoka en-aut-mei=Hitomi kn-aut-name=片岡仁美 kn-aut-sei=片岡 kn-aut-mei=仁美 aut-affil-num=1 ORCID= en-aut-name=ShikataKenichi en-aut-sei=Shikata en-aut-mei=Kenichi kn-aut-name=四方賢一 kn-aut-sei=四方 kn-aut-mei=賢一 aut-affil-num=2 ORCID= en-aut-name=SasakiMotofumi en-aut-sei=Sasaki en-aut-mei=Motofumi kn-aut-name=佐々木基史 kn-aut-sei=佐々木 kn-aut-mei=基史 aut-affil-num=3 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name=槇野博史 kn-aut-sei=槇野 kn-aut-mei=博史 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療教育統合開発センター; 岡山大学大学院医歯薬学総合研究科　腎･免疫･内分泌代謝内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎･免疫･内分泌代謝内科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎･免疫･内分泌代謝内科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎･免疫･内分泌代謝内科学 en-keyword=マクロファージスカベンジャー受容体 kn-keyword=マクロファージスカベンジャー受容体 en-keyword=SR-A kn-keyword=SR-A en-keyword=糖尿病性腎症 kn-keyword=糖尿病性腎症 en-keyword=炎症 kn-keyword=炎症 en-keyword=マクロファージ kn-keyword=マクロファージ END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=2 article-no= start-page=149 end-page=152 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Suicide gene therapy with adenoviral vector delivery of HSV-tk gene and the intravenous administration of ganciclovir for patients with local recurrence of prostate cancer after hormonal therapy kn-title=内分泌療法再燃前立腺癌に対する HSV-tk 遺伝子発現アデノウイルスベクター及びガンシクロビルを用いた自殺遺伝子治療臨床研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=「前立腺癌に対する herpes simplex virus-thymidine kinase遺伝子発現アデノウイルスベクター及びガンシクロビルを用いた遺伝子治療臨床研究」を実施した．対象となる被験者は内分泌療法中に再燃してきた臨床的に遠隔転移を認めない局所再燃前立腺癌とした．まず herpes simplex virus-thymidine kinase（HSV-tk）遺伝子発現アデノウイルスベクターを単独で腫瘍内に直接投与し，その後ガンシクロビル（ganciclovir：GCV）を全身投与した． 　本研究は2001年3月より第1例目の被験者の治療を開始し，平成17年7月に最終登録例である9例目の被験者の治療を実施し，6ヶ月以上観察し，臨床試験を終了とした（8名のべ9症例）． 　9症例すべてにおいて有意な副作用を認めなかった．また，ウイルスベクター投与後の抗アデノウイルス中和抗体価の上昇は軽度でかつ一過性であった．ウイルスベクター投与後，48時間において採取した組織において ｍRNA レベルでの HSV-tk 遺伝子の発現が確認された．治療効果の指標として腫瘍マーカーである PSA は9例中6例において低下した． 　結論として局所再燃前立腺癌に対し，HSV-tk 遺伝子発現アデノウイルスベクターを単独で局所内投与し，その後ガンシクロビルを全身投与することの安全性および治療効果が確認された． en-copyright= kn-copyright= en-aut-name=NasuYasutomo en-aut-sei=Nasu en-aut-mei=Yasutomo kn-aut-name=那須保友 kn-aut-sei=那須 kn-aut-mei=保友 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 en-keyword=前立腺癌 kn-keyword=前立腺癌 en-keyword=遺伝子治療 kn-keyword=遺伝子治療 en-keyword=アデノウイルスベクター kn-keyword=アデノウイルスベクター END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=2 article-no= start-page=153 end-page=157 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Adult neural stem and progenitor cell transplantation in CNS diseases kn-title=中枢神経疾患に対する成体由来神経幹細胞移植 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KamedaMasahiro en-aut-sei=Kameda en-aut-mei=Masahiro kn-aut-name=亀田雅博 kn-aut-sei=亀田 kn-aut-mei=雅博 aut-affil-num=1 ORCID= en-aut-name=ShingoTetsuro en-aut-sei=Shingo en-aut-mei=Tetsuro kn-aut-name=新郷哲郎 kn-aut-sei=新郷 kn-aut-mei=哲郎 aut-affil-num=2 ORCID= en-aut-name=MuraokaKenichiro en-aut-sei=Muraoka en-aut-mei=Kenichiro kn-aut-name=村岡賢一郎 kn-aut-sei=村岡 kn-aut-mei=賢一郎 aut-affil-num=3 ORCID= en-aut-name=TakahashiKazuya en-aut-sei=Takahashi en-aut-mei=Kazuya kn-aut-name=高橋和也 kn-aut-sei=高橋 kn-aut-mei=和也 aut-affil-num=4 ORCID= en-aut-name=YasuharaTakao en-aut-sei=Yasuhara en-aut-mei=Takao kn-aut-name=安原隆雄 kn-aut-sei=安原 kn-aut-mei=隆雄 aut-affil-num=5 ORCID= en-aut-name=DateIsao en-aut-sei=Date en-aut-mei=Isao kn-aut-name=伊達勲 kn-aut-sei=伊達 kn-aut-mei=勲 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　脳神経外科学 en-keyword=成体由来神経幹細胞 kn-keyword=成体由来神経幹細胞 en-keyword=脳内移植 kn-keyword=脳内移植 en-keyword=グリア細胞株由来神経栄養因子（GDNF) kn-keyword=グリア細胞株由来神経栄養因子（GDNF) en-keyword=脳虚血 kn-keyword=脳虚血 en-keyword=パーキンソン病 kn-keyword=パーキンソン病 END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=2 article-no= start-page=159 end-page=168 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Examination of dialysis patients by a systematic review focused on serum phosphorus value kn-title=透析患者における至適血清リン値に関する文献による検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In November 2006, The Japanese Society for Dialysis Therapy (JSDT) announced its first guideline, "The guideline for the management of secondary hyperparathyroidism in chronic dialysis patients," which gives the recommended range of management target values, especially for serum phosphorus, corrected serum calcium and serum intact parathyroid hormone concentrations. Recent studies have suggested that these factors are independently associated with mortality, especially increased cardiovascular mortality. In this research we focused on the serum phosphorus concentration because it is the highest clinical factor among these three. We systematically reviewed almost all documents that discussed the relation between serum phosphorus concentration and mortality as well as the "range of the management target value" specified by foreign guidelines from the US, UK, Canada, Australia and other countries. We summarized the finding concerning the serum phosphorus value of dialysis patients (especially the upper bound value). As a result, it was found that the "range of the management target value" varied among these guidelines. The reasons for this variation likely included differences in the measurement day, in the categories of serum phosphorus concentration, and in the exposure conditions among the studies to which the guidelines referred. Moreover, it was concluded that the Japanese guideline announced by the JSDT should be updated based on the results of future studies. en-copyright= kn-copyright= en-aut-name=TsukijiMakoto en-aut-sei=Tsukiji en-aut-mei=Makoto kn-aut-name=築地淳 kn-aut-sei=築地 kn-aut-mei=淳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院環境学研究科　生命環境学専攻　国際保健学分野 en-keyword=透析患者 (dialysis patients) kn-keyword=透析患者 (dialysis patients) en-keyword=血清リン値 (phosphatemia) kn-keyword=血清リン値 (phosphatemia) en-keyword=CKD-MBD kn-keyword=CKD-MBD en-keyword=ガイドライン (guideline) kn-keyword=ガイドライン (guideline) en-keyword=生命予後 (prognosis) kn-keyword=生命予後 (prognosis) en-keyword=JSDT kn-keyword=JSDT END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=2 article-no= start-page=169 end-page=173 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Nonfunctioning endocrine tumor of the pancreas：A case report kn-title=非機能性膵内分泌腫瘍の１切除例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report a rare case of a very large nonfunctioning endocrine tumor of the pancreas without malignant histological features. A 63-year-old woman referred for appetite loss and general fatigue was found to have a tumor in the pancreas head. Computed tomography demonstrated a well-defined pancreatic tumor 45mm in diameter with hypervascular staining in the pancreas head. Angiography showed a hypervascular tumor of the pancreas head and a dilatation of the anterior superior and posterior superior pancreaticoduodenal arteries. The preoperative diagnosis was an endocrine tumor of the pancreas, with undeniable malignancy. Pylorus-preserving pancreaticoduodenectomy was performed. The histopathological diagnosis was a benign nonfunctioning endocrine tumor of the pancreas based on immunohistochemical staining for Chromogranin A, Synaptophysin, and NSE, but not for hormones. The tumor revealed a low labeling index (<2.0%) of Ki-67 indicating its benign character. No tumor recurrence has been identified in the 18 months since surgery. en-copyright= kn-copyright= en-aut-name=TsunemitsuYosuke en-aut-sei=Tsunemitsu en-aut-mei=Yosuke kn-aut-name=常光洋輔 kn-aut-sei=常光 kn-aut-mei=洋輔 aut-affil-num=1 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=稲垣優 kn-aut-sei=稲垣 kn-aut-mei=優 aut-affil-num=2 ORCID= en-aut-name=HamanoRyosuke en-aut-sei=Hamano en-aut-mei=Ryosuke kn-aut-name=濱野亮輔 kn-aut-sei=濱野 kn-aut-mei=亮輔 aut-affil-num=3 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=4 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=徳永尚之 kn-aut-sei=徳永 kn-aut-mei=尚之 aut-affil-num=5 ORCID= en-aut-name=OtsukaShinya en-aut-sei=Otsuka en-aut-mei=Shinya kn-aut-name=大塚眞哉 kn-aut-sei=大塚 kn-aut-mei=眞哉 aut-affil-num=6 ORCID= en-aut-name=OsakiToshihide en-aut-sei=Osaki en-aut-mei=Toshihide kn-aut-name=大崎俊英 kn-aut-sei=大崎 kn-aut-mei=俊英 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kn-affil=岡山大学大学院医歯薬学総合研究科 en-keyword=ラジオ波焼灼療法 kn-keyword=ラジオ波焼灼療法 en-keyword=縦隔リンパ節転移 kn-keyword=縦隔リンパ節転移 en-keyword=食道癌 kn-keyword=食道癌 en-keyword=気管冷却 kn-keyword=気管冷却 en-keyword=温度モニタリング kn-keyword=温度モニタリング END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=2 article-no= start-page=109 end-page=112 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=自然免疫/炎症とサイトカイン・シグナル伝達 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松川昭博 kn-aut-sei=松川 kn-aut-mei=昭博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 en-keyword=サイトカイン kn-keyword=サイトカイン en-keyword=ケモカイン kn-keyword=ケモカイン en-keyword=自然免疫 kn-keyword=自然免疫 en-keyword=炎症 kn-keyword=炎症 en-keyword=シグナル伝達 kn-keyword=シグナル伝達 END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=2 article-no= start-page=113 end-page=117 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Current status of lung transplantation kn-title=肺移植の現状 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=伊達洋至 kn-aut-sei=伊達 kn-aut-mei=洋至 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 en-keyword=肺移植 kn-keyword=肺移植 en-keyword=脳死肺移植 kn-keyword=脳死肺移植 en-keyword=生体肺移植 kn-keyword=生体肺移植 en-keyword=ドナー kn-keyword=ドナー en-keyword=レシピエント kn-keyword=レシピエント END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=2 article-no= start-page=119 end-page=121 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Discrepancies between pathological examination and imaging analysis after primary systemic chemotherapy for breast cancer: report of two cases kn-title=乳癌術前化学療法の効果判定における画像診断 われわれが経験した病理判定と画像診断の不一致症例について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Primary systemic chemotherapy (PSC) in breast cancer prolongs disease-free survival in patients who have obtained pathological complete remission (pCR). In combination with pathological examination, CT and MRI have been used to evaluate the efficacy of PSC, they generally coincide well with pathological evaluation. We here present two cases showing discrepancies between pathological examination and imaging analysis after PSC in breast cancer. We should keep such discrepancies in mind to determine the ideal treatment after PSC. An accurate method of evaluating cellular damage by PSC is needed. en-copyright= kn-copyright= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=1 ORCID= en-aut-name=TabuchiYoko en-aut-sei=Tabuchi en-aut-mei=Yoko kn-aut-name=田渕陽子 kn-aut-sei=田渕 kn-aut-mei=陽子 aut-affil-num=2 ORCID= en-aut-name=ItoMitsuya en-aut-sei=Ito en-aut-mei=Mitsuya kn-aut-name=伊藤充矢 kn-aut-sei=伊藤 kn-aut-mei=充矢 aut-affil-num=3 ORCID= en-aut-name=OnoRyoko en-aut-sei=Ono en-aut-mei=Ryoko kn-aut-name=小野亮子 kn-aut-sei=小野 kn-aut-mei=亮子 aut-affil-num=4 ORCID= en-aut-name=ImadaTakako en-aut-sei=Imada en-aut-mei=Takako kn-aut-name=今田孝子 kn-aut-sei=今田 kn-aut-mei=孝子 aut-affil-num=5 ORCID= en-aut-name=MotokiTakayuki en-aut-sei=Motoki en-aut-mei=Takayuki kn-aut-name=元木崇之 kn-aut-sei=元木 kn-aut-mei=崇之 aut-affil-num=6 ORCID= en-aut-name=MatsukawaHiroyosi en-aut-sei=Matsukawa en-aut-mei=Hiroyosi kn-aut-name=松川啓義 kn-aut-sei=松川 kn-aut-mei=啓義 aut-affil-num=7 ORCID= en-aut-name=OhmoriMasako en-aut-sei=Ohmori en-aut-mei=Masako kn-aut-name=大森昌子 kn-aut-sei=大森 kn-aut-mei=昌子 aut-affil-num=8 ORCID= en-aut-name=YanaiHiroyuki en-aut-sei=Yanai en-aut-mei=Hiroyuki kn-aut-name=柳井広之 kn-aut-sei=柳井 kn-aut-mei=広之 aut-affil-num=9 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=10 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科 affil-num=2 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科 affil-num=3 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科 affil-num=4 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科 affil-num=5 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科 affil-num=6 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科 affil-num=7 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科 affil-num=8 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　病理部 affil-num=9 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　病理部 affil-num=10 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科 affil-num=11 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　消化器腫瘍外科 en-keyword=術前化学療法（Primary Systemic Chemotherapy） kn-keyword=術前化学療法（Primary Systemic Chemotherapy） en-keyword=画像診断（Imaging Analysis） kn-keyword=画像診断（Imaging Analysis） en-keyword=MRI kn-keyword=MRI en-keyword=CT kn-keyword=CT END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=1 article-no= start-page=9 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=テロメラーゼ特異的に増幅するGFP蛋白を用いたマウスの固形腫瘍の胸膜播種の可視化 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=梅岡達生 kn-aut-sei=梅岡 kn-aut-mei=達生 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=川嶋健 kn-aut-sei=川嶋 kn-aut-mei=健 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=香川俊輔 kn-aut-sei=香川 kn-aut-mei=俊輔 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=寺石文則 kn-aut-sei=寺石 kn-aut-mei=文則 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=滝正樹 kn-aut-sei=滝 kn-aut-mei=正樹 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=京哲 kn-aut-sei=京 kn-aut-mei=哲 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=永井勝幸 kn-aut-sei=永井 kn-aut-mei=勝幸 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=浦田泰生 kn-aut-sei=浦田 kn-aut-mei=泰生 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=9 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍制御学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍制御学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍制御学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍制御学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍制御学 affil-num=6 en-affil= kn-affil=金沢大学医学部　産婦人科学 affil-num=7 en-affil= kn-affil=オンコリス．バイオファーマ affil-num=8 en-affil= kn-affil=オンコリス．バイオファーマ affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍制御学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍制御学 en-keyword=GFP kn-keyword=GFP en-keyword=アデノウイルス kn-keyword=アデノウイルス en-keyword=テロメラーゼ kn-keyword=テロメラーゼ en-keyword=増幅 kn-keyword=増幅 en-keyword=遺伝子治療 kn-keyword=遺伝子治療 END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=1 article-no= start-page=17 end-page=21 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=原発性肺高血圧症の病態形成における骨形成蛋白（BMP）Ⅰ型受容体の関与とその意義：肺動脈血管平滑筋細胞を用いた検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=武田昌也 kn-aut-sei=武田 kn-aut-mei=昌也 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大塚文男 kn-aut-sei=大塚 kn-aut-mei=文男 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中村一文 kn-aut-sei=中村 kn-aut-mei=一文 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=稲垣兼一 kn-aut-sei=稲垣 kn-aut-mei=兼一 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=鈴木二郎 kn-aut-sei=鈴木 kn-aut-mei=二郎 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三浦大志 kn-aut-sei=三浦 kn-aut-mei=大志 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤尾栄起 kn-aut-sei=藤尾 kn-aut-mei=栄起 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松原広己 kn-aut-sei=松原 kn-aut-mei=広己 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=伊達洋至 kn-aut-sei=伊達 kn-aut-mei=洋至 aut-affil-num=9 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大江透 kn-aut-sei=大江 kn-aut-mei=透 aut-affil-num=10 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=槇野博史 kn-aut-sei=槇野 kn-aut-mei=博史 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　循環器内科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　循環器内科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　循環器内科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　循環器内科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍・胸部外科学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　循環器内科学 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 en-keyword=原発性肺高血圧症 (PPH) kn-keyword=原発性肺高血圧症 (PPH) en-keyword=骨形成蛋白 (BMP) kn-keyword=骨形成蛋白 (BMP) en-keyword=肺動脈血管平滑筋細胞 kn-keyword=肺動脈血管平滑筋細胞 en-keyword=TGF-β スーパーファミリー kn-keyword=TGF-β スーパーファミリー en-keyword=BMP IＢ型受容体 (ALK-6) kn-keyword=BMP IＢ型受容体 (ALK-6) END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=2 article-no= start-page=123 end-page=125 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Duct lavage cytology for the detection of breast cancer: report of a case kn-title=乳管洗浄細胞診が診断に有効であった乳癌の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although many modalities have been established to diagnose breast cancers, it is sometimes difficult to reveal nonpalpable cases. Duct lavage cytology was originally established to reveal groups at high risk for breast cancers by detecting metaplastic ductal cells. We report here a case where duct lavage was useful for revealing a small cancer that had been undetected by repeated bloody nipple discharge and cytological examinations. Duct lavage cytology may be of use in cases where nipple discharge of unknown origin persists. en-copyright= kn-copyright= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=1 ORCID= en-aut-name=TabuchiYoko en-aut-sei=Tabuchi en-aut-mei=Yoko kn-aut-name=田渕陽子 kn-aut-sei=田渕 kn-aut-mei=陽子 aut-affil-num=2 ORCID= en-aut-name=OnoRyoko en-aut-sei=Ono en-aut-mei=Ryoko kn-aut-name=小野亮子 kn-aut-sei=小野 kn-aut-mei=亮子 aut-affil-num=3 ORCID= en-aut-name=ImadaTakako en-aut-sei=Imada en-aut-mei=Takako kn-aut-name=今田孝子 kn-aut-sei=今田 kn-aut-mei=孝子 aut-affil-num=4 ORCID= en-aut-name=UmeokaTatsuo en-aut-sei=Umeoka en-aut-mei=Tatsuo kn-aut-name=梅岡達生 kn-aut-sei=梅岡 kn-aut-mei=達生 aut-affil-num=5 ORCID= en-aut-name=WatanabeNaoki en-aut-sei=Watanabe en-aut-mei=Naoki kn-aut-name=渡辺直樹 kn-aut-sei=渡辺 kn-aut-mei=直樹 aut-affil-num=6 ORCID= en-aut-name=MotokiTakayuki en-aut-sei=Motoki en-aut-mei=Takayuki kn-aut-name=元木崇之 kn-aut-sei=元木 kn-aut-mei=崇之 aut-affil-num=7 ORCID= en-aut-name=MatsukawaHiroyosi en-aut-sei=Matsukawa en-aut-mei=Hiroyosi kn-aut-name=松川啓義 kn-aut-sei=松川 kn-aut-mei=啓義 aut-affil-num=8 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=9 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=10 ORCID= en-aut-name=YanaiHiroyuki en-aut-sei=Yanai en-aut-mei=Hiroyuki kn-aut-name=柳井広之 kn-aut-sei=柳井 kn-aut-mei=広之 aut-affil-num=11 ORCID= en-aut-name=OmoriMasako en-aut-sei=Omori en-aut-mei=Masako kn-aut-name=大森昌子 kn-aut-sei=大森 kn-aut-mei=昌子 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=11 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　病理部 affil-num=12 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　病理部 en-keyword=乳管洗浄細胞診 (Ductal lavage cytology) kn-keyword=乳管洗浄細胞診 (Ductal lavage cytology) en-keyword=乳癌 (breast cancer) kn-keyword=乳癌 (breast cancer) en-keyword=診断 (diagnosis) kn-keyword=診断 (diagnosis) END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=1 article-no= start-page=23 end-page=31 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=メカノバイオロジー―基礎から臨床まで― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=成瀬恵治 kn-aut-sei=成瀬 kn-aut-mei=恵治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　システム循環生理学 en-keyword=メカノトランスダクション kn-keyword=メカノトランスダクション en-keyword=ソフトリソグラフィー kn-keyword=ソフトリソグラフィー en-keyword=再生医療 kn-keyword=再生医療 en-keyword=不妊治療 kn-keyword=不妊治療 END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=3 article-no= start-page=205 end-page=208 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=蛋白導入システム“Protein Transduction System”を利用したプロテインセラピーの発展と現状について― 悪性脳腫瘍に対する蛋白導入法の利用を中心に ― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=道上宏之 kn-aut-sei=道上 kn-aut-mei=宏之 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=富澤一仁 kn-aut-sei=富澤 kn-aut-mei=一仁 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=魏范研 kn-aut-sei=魏 kn-aut-mei=范研 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松下正之 kn-aut-sei=松下 kn-aut-mei=正之 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=陸雲飛 kn-aut-sei=陸 kn-aut-mei=雲飛 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=市川智継 kn-aut-sei=市川 kn-aut-mei=智継 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田宮隆 kn-aut-sei=田宮 kn-aut-mei=隆 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松井秀樹 kn-aut-sei=松井 kn-aut-mei=秀樹 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=伊達勲 kn-aut-sei=伊達 kn-aut-mei=勲 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学 affil-num=7 en-affil= kn-affil=香川大学医学部　脳神経外科 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　神経病態外科学 en-keyword=プロテインセラピー kn-keyword=プロテインセラピー en-keyword=悪性脳腫瘍 kn-keyword=悪性脳腫瘍 en-keyword=p 53 kn-keyword=p 53 en-keyword=エンドソーム kn-keyword=エンドソーム en-keyword=蛋白導入ドメイン kn-keyword=蛋白導入ドメイン END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=2 article-no= start-page=127 end-page=129 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Localization of nonpalpable breast cancers using VATS marking system under ultrasonographic guidance kn-title=非触知乳癌におけるVATSマーカーを用いたエコーガイド下マーキングの有用性 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A preoperative tumor guiding system for nonpalpable breast cancer using a VATS guiding needle (Hakko Co., Ltd., Tokyo Japan) was reported. It was easy to introduce the guiding needle into breast cancers smaller than 1cm under ultrasonographic observation. Neither bleeding nor infection was experienced. Wound management was easy and painless. This guiding system is very useful for locating and managing nonpalpable breast cancers even in outpatient settings. en-copyright= kn-copyright= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=1 ORCID= en-aut-name=TabuchiYoko en-aut-sei=Tabuchi en-aut-mei=Yoko kn-aut-name=田渕陽子 kn-aut-sei=田渕 kn-aut-mei=陽子 aut-affil-num=2 ORCID= en-aut-name=ItoMitsuya en-aut-sei=Ito en-aut-mei=Mitsuya kn-aut-name=伊藤充矢 kn-aut-sei=伊藤 kn-aut-mei=充矢 aut-affil-num=3 ORCID= en-aut-name=OnoRyoko en-aut-sei=Ono en-aut-mei=Ryoko kn-aut-name=小野亮子 kn-aut-sei=小野 kn-aut-mei=亮子 aut-affil-num=4 ORCID= en-aut-name=ImadaTakako en-aut-sei=Imada en-aut-mei=Takako kn-aut-name=今田孝子 kn-aut-sei=今田 kn-aut-mei=孝子 aut-affil-num=5 ORCID= en-aut-name=MatsukawaHiroyosi en-aut-sei=Matsukawa en-aut-mei=Hiroyosi kn-aut-name=松川啓義 kn-aut-sei=松川 kn-aut-mei=啓義 aut-affil-num=6 ORCID= en-aut-name=MotokiTakayuki en-aut-sei=Motoki en-aut-mei=Takayuki kn-aut-name=元木崇之 kn-aut-sei=元木 kn-aut-mei=崇之 aut-affil-num=7 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=8 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name=金澤右 kn-aut-sei=金澤 kn-aut-mei=右 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 消化器腫瘍外科 affil-num=2 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 消化器腫瘍外科 affil-num=3 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 消化器腫瘍外科 affil-num=4 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 消化器腫瘍外科 affil-num=5 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 消化器腫瘍外科 affil-num=6 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 消化器腫瘍外科 affil-num=7 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 消化器腫瘍外科 affil-num=8 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 消化器腫瘍外科 affil-num=9 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 放射線科 en-keyword=非触知乳癌 (nonpalpable breast cancer) kn-keyword=非触知乳癌 (nonpalpable breast cancer) en-keyword=マーキング (marking) kn-keyword=マーキング (marking) en-keyword=エコーガイド (guiding echo) kn-keyword=エコーガイド (guiding echo) en-keyword=VATS マーカー (VATS marker) kn-keyword=VATS マーカー (VATS marker) END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=3 article-no= start-page=209 end-page=213 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ボツリヌスC型とD型神経毒素を支配するバクテリオファージの遺伝子解析と溶原化の分子機構 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=阪口義彦 kn-aut-sei=阪口 kn-aut-mei=義彦 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=林哲也 kn-aut-sei=林 kn-aut-mei=哲也 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=黒川顕 kn-aut-sei=黒川 kn-aut-mei=顕 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中山恵介 kn-aut-sei=中山 kn-aut-mei=恵介 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大島健志郎 kn-aut-sei=大島 kn-aut-mei=健志郎 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤永由佳子 kn-aut-sei=藤永 kn-aut-mei=由佳子 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大西真 kn-aut-sei=大西 kn-aut-mei=真 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大坪栄一 kn-aut-sei=大坪 kn-aut-mei=栄一 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=服部正平 kn-aut-sei=服部 kn-aut-mei=正平 aut-affil-num=9 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小熊惠二 kn-aut-sei=小熊 kn-aut-mei=惠二 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　病原細菌学 affil-num=2 en-affil= kn-affil=宮崎大学フロンティア科学実験総合センター　生命科学研究部門生命環境科学分野 affil-num=3 en-affil= kn-affil=奈良先端科学技術大学院大学情報科学研究科　比較ゲノム affil-num=4 en-affil= kn-affil=宮崎大学医学部医学科　感染症学 affil-num=5 en-affil= kn-affil=北里大学生命科学研究所 affil-num=6 en-affil= kn-affil=大阪大学微生物病研究所附属感染症国際研究センター affil-num=7 en-affil= kn-affil=国立感染症研究所　細菌第一部 affil-num=8 en-affil= kn-affil=東京大学分子細胞生物学研究所　分子情報・制御 affil-num=9 en-affil= kn-affil=北里大学生命科学研究所 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　病原細菌学 en-keyword=バクテリオファージ kn-keyword=バクテリオファージ en-keyword=ボツリヌス毒素 kn-keyword=ボツリヌス毒素 en-keyword=挿入配列 kn-keyword=挿入配列 en-keyword=プラスミド kn-keyword=プラスミド en-keyword=プロファージ kn-keyword=プロファージ END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=3 article-no= start-page=221 end-page=224 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=IgG4関連自己免疫疾患 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療教育統合開発センター en-keyword=IgG4関連自己免疫疾患 kn-keyword=IgG4関連自己免疫疾患 en-keyword=自己免疫性膵炎 kn-keyword=自己免疫性膵炎 en-keyword=後腹膜線維症 kn-keyword=後腹膜線維症 en-keyword=Mikulicz 病 kn-keyword=Mikulicz 病 en-keyword=IgG4 kn-keyword=IgG4 END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=3 article-no= start-page=251 end-page=257 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=環境科学の視点からみたアレルギー疾患の課題と対策 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山本秀樹 kn-aut-sei=山本 kn-aut-mei=秀樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院環境学研究科　生命環境学専攻国際保健学分野 en-keyword=Hygiene hypothesis (衛生仮説) kn-keyword=Hygiene hypothesis (衛生仮説) en-keyword=花粉症 kn-keyword=花粉症 en-keyword=公害喘息 kn-keyword=公害喘息 en-keyword=シックハウス症候群 kn-keyword=シックハウス症候群 en-keyword=災害 kn-keyword=災害 en-keyword=環境科学 kn-keyword=環境科学 END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=2 article-no= start-page=131 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=眼科領域のアレルギー性疾患とアトピー性皮膚炎の眼合併症 en-subtitle= kn-subtitle= en-abstract= kn-abstract=アレルギー反応の4型, 1型 (lgE依存型反応), 1型 (細胞障害型反応), III型 (免疫複合体型反応), IV型 (細胞免疫型反応) を眼科疾患に当てはめると, I型はアレルギー性結膜疾患, II型は眼類天庖瘡やモーレン (Mooren) 角膜潰瘍などの自己免疫疾患, III型はぶどう球菌アレルギーによる周辺部角膜浸潤, IV型は角膜や結膜ブリクテン, 接触性皮膚炎による眼瞼炎, となる. その他, アレルギー関連疾患として, アトピー性皮膚炎がある. アトピー性皮膚炎は, 小児期の疾患であり, 通常, 皮膚は乾燥している. しかし日本では, 思春期から青年期, さらには成人になってから発症する型がある. この型は, 顔面におこることが多く, しかも皮膚は乾燥しておらず, 湿潤している. アトピー性白内障は, 顔面, 特に眼瞼に皮膚炎がある場合に見られる. 問診すると, 特に就寝時に眼瞼をたたく癖がある. アトピー性網膜剥離は, 通常, 白内障がある眼に起こっている. 硝子体手術を行うと, 硝子体基底部の綿状のきたない混濁がみられ, その近辺に鋸状縁断裂, 毛様体無色素上皮剥離や上皮裂孔がある. 一方, アトピー性白内障がある眼では, 前房水中のフレア値 (蛋白濃度) が上昇している. 以上の事実から, アトピー性皮膚炎の炎症が前眼部に波及し, それに眼瞼をたたくという外傷が加わって白内障や網膜剥離がおこると考えられる. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松尾俊彦 kn-aut-sei=松尾 kn-aut-mei=俊彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 眼科学 en-keyword=アレルギー性結膜炎 kn-keyword=アレルギー性結膜炎 en-keyword=春季カタル kn-keyword=春季カタル en-keyword=巨大乳頭結膜炎 kn-keyword=巨大乳頭結膜炎 en-keyword=アトピー性皮膚炎 kn-keyword=アトピー性皮膚炎 en-keyword=アトピー性網膜剥離 kn-keyword=アトピー性網膜剥離 en-keyword=アトピー性白内障 kn-keyword=アトピー性白内障 END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=1 article-no= start-page=41 end-page=45 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Two cases of acute pulmonary embolism after esophageal cancer operation kn-title=早期診断し得た食道癌術後静脈血栓塞栓症の2例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We encountered two cases of pulmonary embolism (PE)/venous thrombs (DVT) after surgery for esophageal cancer. The first case was a 58-year-old male. He underwent a subtotal esophagectomy and reconstruction using the stomach via the subcutaneus route. His postoperative course was stable; however, 13 days after the operation､ he had an elevated fever and pulmonary thrombi were observed on CT-scan screening. Scintigraphy confirmed the thrombi. An inferior vena cava filter (IVCF) was inserted and anti-coagulation therapy using heparin was started. His fever subsided, and 35 days after the operation, the thrombi disappeared. He was discharged thereafter and is being followed up using warfarin. The second case was a 74-year-old male. He also underwent subtotal esophagectomy and reconstruction using the stomach via the subcutaneus route. A central line was inserted via right femoral vein; however, the artery was injured and pressurization to the vessel was needed. His post-operative course was stable and symptom-free; however, ultrasound screening detected DVT in his right femoral vein. IVCF was mserted and anti-coagulation therapy was begun, thrombi disappeared 8 days after the therapy. en-copyright= kn-copyright= en-aut-name=KanazawaTakashi en-aut-sei=Kanazawa en-aut-mei=Takashi kn-aut-name=金澤卓 kn-aut-sei=金澤 kn-aut-mei=卓 aut-affil-num=1 ORCID= en-aut-name=WatababeNobuyuki en-aut-sei=Watababe en-aut-mei=Nobuyuki kn-aut-name=渡辺信之 kn-aut-sei=渡辺 kn-aut-mei=信之 aut-affil-num=2 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=3 ORCID= en-aut-name=KobayashiMasahiko en-aut-sei=Kobayashi en-aut-mei=Masahiko kn-aut-name=小林正彦 kn-aut-sei=小林 kn-aut-mei=正彦 aut-affil-num=4 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name=白川靖博 kn-aut-sei=白川 kn-aut-mei=靖博 aut-affil-num=5 ORCID= en-aut-name=YamatsujiTomoki en-aut-sei=Yamatsuji en-aut-mei=Tomoki kn-aut-name=山辻知樹 kn-aut-sei=山辻 kn-aut-mei=知樹 aut-affil-num=6 ORCID= en-aut-name=KobayashiNaoya en-aut-sei=Kobayashi en-aut-mei=Naoya kn-aut-name=小林直哉 kn-aut-sei=小林 kn-aut-mei=直哉 aut-affil-num=7 ORCID= en-aut-name=FujiwaraTohsiyoshi en-aut-sei=Fujiwara en-aut-mei=Tohsiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=8 ORCID= en-aut-name=MatsubaraNagahide en-aut-sei=Matsubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=9 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=10 ORCID= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=11 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=12 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 en-keyword=食道癌 (esophageal cancer) kn-keyword=食道癌 (esophageal cancer) en-keyword=肺塞栓症 (pulmonary embolism) kn-keyword=肺塞栓症 (pulmonary embolism) en-keyword=深部静脈血栓症 (deep venous thrombs) kn-keyword=深部静脈血栓症 (deep venous thrombs) END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=3 article-no= start-page=199 end-page=203 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=パーキンソン病におけるレビー小体形成のメカニズムに関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=村上哲郎 kn-aut-sei=村上 kn-aut-mei=哲郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　神経内科 en-keyword=パーキンソン病 kn-keyword=パーキンソン病 en-keyword=レビー小体 kn-keyword=レビー小体 en-keyword=α-synucleinopathy kn-keyword=α-synucleinopathy en-keyword=多系統萎縮症 kn-keyword=多系統萎縮症 en-keyword=Pael-R kn-keyword=Pael-R END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=3 article-no= start-page=225 end-page=234 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=3-ニトロチロシン en-subtitle= kn-subtitle= en-abstract= kn-abstract=種々の機序により産生された活性窒素種 (reactive nitrogen species) によるチロシン残基のニトロ化による3-ニトロチロシン (3-NT) の生成は, 蛋白質の翻訳後修飾の一つとして広く認められている.種々の炎症性疾患組織では, 一酸化窒素・二酸化窒素・ペルオキシナイトライトといった活性窒素種が異なる機序で産生され, 3-NTの産生に関与している. チロシンニトロ化蛋白質の同定や, 蛋白質分子中のチロシンニトロ化部位が決定できるようになり, 蛋白質の寿命, 蛋白質問相互作用に対する悪影響, 蛋白質機能喪失との関連づけが可能になってきた. 測定法としては, 免疫組織化学的手法, ウェスタンブロッティングによる半定量法から, ELISA, HPLC-ECD, LC-MS/MS, GC-MS/MSを用いた定量的な方法がある. 本総説では, 3-NTについて, その生成機序, 測定方法, 予防医学的応用を述べる. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=荻野景規 kn-aut-sei=荻野 kn-aut-mei=景規 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　公衆衛生学 en-keyword=3ﾝニトロチロシン kn-keyword=3ﾝニトロチロシン en-keyword=活性窒素種 kn-keyword=活性窒素種 en-keyword=翻訳後修飾 kn-keyword=翻訳後修飾 END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=1 article-no= start-page=47 end-page=52 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=アレルギー疾患総論とアナフィラキシーについて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=金廣有彦 kn-aut-sei=金廣 kn-aut-mei=有彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学 en-keyword=アレルギー遺伝子 kn-keyword=アレルギー遺伝子 en-keyword=アナフィラキシー kn-keyword=アナフィラキシー en-keyword=ラテックス・フルーツ症候群 kn-keyword=ラテックス・フルーツ症候群 en-keyword=ハチ毒アレルギー kn-keyword=ハチ毒アレルギー en-keyword=食物依存性運動誘発アナフィラキシー kn-keyword=食物依存性運動誘発アナフィラキシー END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=1 article-no= start-page=1 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050520 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=桂田富士郎と日本住血吸虫発見100年 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小田晧二 kn-aut-sei=小田 kn-aut-mei=晧二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=医療法人おだうじ会小田病院 en-keyword=日本住血吸虫 kn-keyword=日本住血吸虫 en-keyword=桂田富士郎 kn-keyword=桂田富士郎 en-keyword=岡山医学会 kn-keyword=岡山医学会 END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=1 article-no= start-page=9 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050520 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=糖尿病性腎症の発症・進展における炎症機転の関与 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡田震一 kn-aut-sei=岡田 kn-aut-mei=震一 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=四方賢一 kn-aut-sei=四方 kn-aut-mei=賢一 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=槇野博史 kn-aut-sei=槇野 kn-aut-mei=博史 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科腎･免疫･内分泌代謝内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯学総合研究科腎･免疫･内分泌代謝内科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯学総合研究科腎･免疫･内分泌代謝内科学 en-keyword=糖尿病性腎症 kn-keyword=糖尿病性腎症 en-keyword=マクロファージ kn-keyword=マクロファージ en-keyword=ICAM-１ kn-keyword=ICAM-１ en-keyword=炎症 kn-keyword=炎症 END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=1 article-no= start-page=17 end-page=20 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050520 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=グリア境界膜に局在する新規遺伝子「リミトリン」の発見 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=米澤朋子 kn-aut-sei=米澤 kn-aut-mei=朋子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科分子医化学 en-keyword=血液脳関門 kn-keyword=血液脳関門 en-keyword=アストロサイト kn-keyword=アストロサイト en-keyword=基底膜 kn-keyword=基底膜 en-keyword=グリア境界 kn-keyword=グリア境界 en-keyword=イムノグロブリンスーパーファミリー kn-keyword=イムノグロブリンスーパーファミリー END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=2 article-no= start-page=149 end-page=150 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=(4)アカウンタビリティとは① en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=板谷裕子 kn-aut-sei=板谷 kn-aut-mei=裕子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=東京大学医学教育国際協力研究センター END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=1 article-no= start-page=21 end-page=26 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050520 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Ikaros dominant-negative isoform の過剰発現は dexamethasone や抗IgM 抗体によるapoptosis 誘導を抑制する en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=瀬﨑伸夫 kn-aut-sei=瀬﨑 kn-aut-mei=伸夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=呉共済病院内科 en-keyword=Ikaros kn-keyword=Ikaros en-keyword=dominant-negative isoform kn-keyword=dominant-negative isoform en-keyword=apoptosis kn-keyword=apoptosis END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=1 article-no= start-page=27 end-page=33 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050520 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=腫瘍細胞におけるIGF-Iレセプターの役割と婦人科癌分子標的治療への応用 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=本郷淳司 kn-aut-sei=本郷 kn-aut-mei=淳司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院産科婦人科 en-keyword=Soluble IGF-IR kn-keyword=Soluble IGF-IR en-keyword=Tumorigenesis kn-keyword=Tumorigenesis en-keyword=Apoptosis kn-keyword=Apoptosis en-keyword=Recombinant Protein kn-keyword=Recombinant Protein en-keyword=Bystander Effect kn-keyword=Bystander Effect END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=1 article-no= start-page=35 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050520 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=複合糖質を可視化する en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大塚愛二 kn-aut-sei=大塚 kn-aut-mei=愛二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科人体構成学 en-keyword=複合糖質 kn-keyword=複合糖質 en-keyword=組織化学 kn-keyword=組織化学 en-keyword=プロテオグリカン kn-keyword=プロテオグリカン en-keyword=電子顕微鏡 kn-keyword=電子顕微鏡 en-keyword=光学顕微鏡 kn-keyword=光学顕微鏡 END start-ver=1.4 cd-journal=joma no-vol=118 cd-vols= no-issue=2 article-no= start-page=157 end-page=159 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Fetal origin adult disease (FOAD) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平松祐司 kn-aut-sei=平松 kn-aut-mei=祐司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　産科・婦人科学 END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=2 article-no= start-page=97 end-page=103 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=大腸癌におけるKRAS，BRAF 遺伝子突然変異とDNA メチル化 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=永坂岳司 kn-aut-sei=永坂 kn-aut-mei=岳司 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=笹本博美 kn-aut-sei=笹本 kn-aut-mei=博美 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高畑隆臣 kn-aut-sei=高畑 kn-aut-mei=隆臣 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=竹田正範 kn-aut-sei=竹田 kn-aut-mei=正範 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=木村圭吾 kn-aut-sei=木村 kn-aut-mei=圭吾 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=内田卓之 kn-aut-sei=内田 kn-aut-mei=卓之 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=石井龍宏 kn-aut-sei=石井 kn-aut-mei=龍宏 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=長尾厚樹 kn-aut-sei=長尾 kn-aut-mei=厚樹 aut-affil-num=9 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小南賢吉郎 kn-aut-sei=小南 kn-aut-mei=賢吉郎 aut-affil-num=10 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中川仁志 kn-aut-sei=中川 kn-aut-mei=仁志 aut-affil-num=11 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=神原健 kn-aut-sei=神原 kn-aut-mei=健 aut-affil-num=12 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=能登原憲司 kn-aut-sei=能登原 kn-aut-mei=憲司 aut-affil-num=13 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=磯崎博司 kn-aut-sei=磯崎 kn-aut-mei=博司 aut-affil-num=14 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=12 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=13 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=14 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=15 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 en-keyword=Colorectal Cancer kn-keyword=Colorectal Cancer en-keyword=MSI kn-keyword=MSI en-keyword=DNA Methylation kn-keyword=DNA Methylation en-keyword=KRAS mutation kn-keyword=KRAS mutation en-keyword=BRAF mutation kn-keyword=BRAF mutation END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=1 article-no= start-page=41 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050520 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ボツリヌスC型，D型毒素遺伝子の解析による菌の分類に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clostridium botulinum types C and D toxin production is governed by the specific bacteriophages. A type C phage,c-st,was isolated from a toxigenic strain of C-Stockholm,and its whole genome sequence was determined.The genome was a linear double-stranded 185,681bp DNA with a G＋C content of 26.2%, and identical 403-bp sequences were found at each end of the genome. From the DNA research, 198 potential protein-coding regions (ORFs)were identified. The genes for type C progenitor toxin and C3 exoenzyme were identified, but no type D toxin gene was found.A number of genes were homologous to those of a Bacillus subtilis bacteriophage,SP D. On Southern blot analysis between type C and D cell DNAs and the specific probes for H and L chains of C and D neurotoxins, it became clear that type C and D strains posses only one type of toxin gene.From these findings, it is concluded that cross-neutralization observed between toxins (types C and D)and their antiserums can be caused by the common-antigens in C and D toxins. en-copyright= kn-copyright= en-aut-name=SakaguchiYoshihiko en-aut-sei=Sakaguchi en-aut-mei=Yoshihiko kn-aut-name=阪口義彦 kn-aut-sei=阪口 kn-aut-mei=義彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科病原細菌学 en-keyword=ボツリヌス菌 (Clostridium botulinum) kn-keyword=ボツリヌス菌 (Clostridium botulinum) en-keyword=ファージ (phage) kn-keyword=ファージ (phage) en-keyword=神経毒素遺伝子 (neurotoxin gene) kn-keyword=神経毒素遺伝子 (neurotoxin gene) END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=1 article-no= start-page=47 end-page=50 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050520 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of pulmonary abscess after severe thoracic traumasuccessfully treated with thoracotomy kn-title=重症胸部外傷後肺膿瘍に対し肺葉切除術を施行し救命できた１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Thoracic trauma is rarely managed by major thoracotomy. We report a 61-year-old male patient with pulmonaryabscess after severe thoracic trauma, who was managed successfully by major thoracotomy. The patient was injured after a fall from a height of 6 meters.He developed multiple rib fractures with right flail chest, pulmonary contusion,right hemo-pneumothorax, and subcutaneous emphysema.He was intubated and ventilated, and his chest was drainaged. He had been managed with conservative treatment initially. However he developed a pulmonary abscess in the right lung that was unresponsive to CT-guided drainage therapy. The right lower lobectomy was performed on the 23rd day after his injury. His general condition greatly recovered and all the chest drains were removed on the 45th post trauma day. He was discharged from the hospital on the 86th post operative day. He was considered now fully recovered at 7 months after the accident. en-copyright= kn-copyright= en-aut-name=InukaiMichio en-aut-sei=Inukai en-aut-mei=Michio kn-aut-name=犬飼道雄 kn-aut-sei=犬飼 kn-aut-mei=道雄 aut-affil-num=1 ORCID= en-aut-name=IchibaShingo en-aut-sei=Ichiba en-aut-mei=Shingo kn-aut-name=市場晋吾 kn-aut-sei=市場 kn-aut-mei=晋吾 aut-affil-num=2 ORCID= en-aut-name=TsudaMikako en-aut-sei=Tsuda en-aut-mei=Mikako kn-aut-name=津田美佳子 kn-aut-sei=津田 kn-aut-mei=美佳子 aut-affil-num=3 ORCID= en-aut-name=FujimuraNaoyuki en-aut-sei=Fujimura en-aut-mei=Naoyuki kn-aut-name=藤村直幸 kn-aut-sei=藤村 kn-aut-mei=直幸 aut-affil-num=4 ORCID= en-aut-name=UjikeYoshihito en-aut-sei=Ujike en-aut-mei=Yoshihito kn-aut-name=氏家良人 kn-aut-sei=氏家 kn-aut-mei=良人 aut-affil-num=5 ORCID= en-aut-name=IchiharaSyuji en-aut-sei=Ichihara en-aut-mei=Syuji kn-aut-name=市原周治 kn-aut-sei=市原 kn-aut-mei=周治 aut-affil-num=6 ORCID= en-aut-name=AoiMotoi en-aut-sei=Aoi en-aut-mei=Motoi kn-aut-name=青江基 kn-aut-sei=青江 kn-aut-mei=基 aut-affil-num=7 ORCID= en-aut-name=SanoYoshifumi en-aut-sei=Sano en-aut-mei=Yoshifumi kn-aut-name=佐野由文 kn-aut-sei=佐野 kn-aut-mei=由文 aut-affil-num=8 ORCID= en-aut-name=DateHiroshi en-aut-sei=Date en-aut-mei=Hiroshi kn-aut-name=伊達洋至 kn-aut-sei=伊達 kn-aut-mei=洋至 aut-affil-num=9 ORCID= en-aut-name=ShimizuNobuyoshi en-aut-sei=Shimizu en-aut-mei=Nobuyoshi kn-aut-name=清水信義 kn-aut-sei=清水 kn-aut-mei=信義 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 腫瘍胸部外科 affil-num=2 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 救急部 affil-num=3 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 救急部 affil-num=4 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 救急部 affil-num=5 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 救急部 affil-num=6 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 腫瘍胸部外科 affil-num=7 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 腫瘍胸部外科 affil-num=8 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 腫瘍胸部外科 affil-num=9 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 腫瘍胸部外科 affil-num=10 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 腫瘍胸部外科 en-keyword=胸部外傷 (Chest trauma) kn-keyword=胸部外傷 (Chest trauma) en-keyword=肺膿瘍 (Pulmonary abscess) kn-keyword=肺膿瘍 (Pulmonary abscess) en-keyword=肺挫傷 (Pulmonary contusion) kn-keyword=肺挫傷 (Pulmonary contusion) en-keyword=肺葉切除術 (Lobectomy) kn-keyword=肺葉切除術 (Lobectomy) END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=1 article-no= start-page=51 end-page=59 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050520 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=③医療の事業経営論/医療業の経営持続性を考える en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西田在賢 kn-aut-sei=西田 kn-aut-mei=在賢 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=武蔵野大学大学院 en-keyword=病院経営持続性 kn-keyword=病院経営持続性 en-keyword=固定費事業 kn-keyword=固定費事業 en-keyword=倒産 kn-keyword=倒産 en-keyword=病床当り流動負債 kn-keyword=病床当り流動負債 END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=2 article-no= start-page=105 end-page=108 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=蛋白導入システムによる薬剤開発と膵島移植への応用 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=野口洋文 kn-aut-sei=野口 kn-aut-mei=洋文 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松下正之 kn-aut-sei=松下 kn-aut-mei=正之 aut-affil-num=2 ORCID= en-aut-name=KobayashiNaoya en-aut-sei=Kobayashi en-aut-mei=Naoya kn-aut-name=小林直哉 kn-aut-sei=小林 kn-aut-mei=直哉 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=SusanBonner-Weir kn-aut-sei=Susan kn-aut-mei=Bonner-Weir aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松井秀樹 kn-aut-sei=松井 kn-aut-mei=秀樹 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田中紘一 kn-aut-sei=田中 kn-aut-mei=紘一 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松本慎一 kn-aut-sei=松本 kn-aut-mei=慎一 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=京都大学医学部附属病院移植外科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科細胞生理学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=4 en-affil= kn-affil=ハーバード大学ジョスリン糖尿病センター affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科細胞生理学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科消化器・腫瘍外科学 affil-num=7 en-affil= kn-affil=先端医療振興財団先端医療センター affil-num=8 en-affil= kn-affil=京都大学医学部附属病院臓器移植医療部 en-keyword=蛋白導入システム kn-keyword=蛋白導入システム en-keyword=膵島移植 kn-keyword=膵島移植 en-keyword=膵島再生 kn-keyword=膵島再生 en-keyword=免疫抑制剤 kn-keyword=免疫抑制剤 en-keyword=膵島分離技術 kn-keyword=膵島分離技術 END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=1 article-no= start-page=85 end-page=86 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050520 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ノロウイルス en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小倉肇 kn-aut-sei=小倉 kn-aut-mei=肇 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山県環境保健センター END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=3 article-no= start-page=187 end-page=191 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=活性酸素によるRB タンパクの酸化を介した細胞周期停止 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=寳迫睦美 kn-aut-sei=寳迫 kn-aut-mei=睦美 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=荻野哲也 kn-aut-sei=荻野 kn-aut-mei=哲也 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡田茂 kn-aut-sei=岡田 kn-aut-mei=茂 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病態探究医学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病態探究医学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病態探究医学 en-keyword=細胞周期 kn-keyword=細胞周期 en-keyword=RB タンパク kn-keyword=RB タンパク en-keyword=活性酸素 kn-keyword=活性酸素 en-keyword=モノクロラミン kn-keyword=モノクロラミン en-keyword=酸化ストレス kn-keyword=酸化ストレス END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=2 article-no= start-page=109 end-page=118 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=誘導性ヒスタミンはＨ(2)受容体刺激を介してP.ances-LPS 誘発性肝炎からマウスを保護する en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=横山穣 kn-aut-sei=横山 kn-aut-mei=穣 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科薬理学 en-keyword=内因性ヒスタミン kn-keyword=内因性ヒスタミン en-keyword=サイトカイン kn-keyword=サイトカイン en-keyword=マウス急性肝炎 kn-keyword=マウス急性肝炎 END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=3 article-no= start-page=215 end-page=220 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=新しい核内受容体 Pregnane X Receptor の生殖生理における役割―岡山大学医学賞（林原賞）を受賞して― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=増山寿 kn-aut-sei=増山 kn-aut-mei=寿 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　産科婦人科 en-keyword=pregnane X receptor kn-keyword=pregnane X receptor en-keyword=steroidogenesis kn-keyword=steroidogenesis en-keyword=cytochrome P450 kn-keyword=cytochrome P450 en-keyword=drug resistance kn-keyword=drug resistance END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=3 article-no= start-page=221 end-page=228 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ヒトの大腸癌細胞におけるTNFとINF-αの併用刺激によるApoptosisの増強のメカニズム, 特にNF-κBが誘導するFasの発現の増強を介した新しいシグナル伝達について―岡山大学医学賞（林原賞）を受賞して― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=木村真士 kn-aut-sei=木村 kn-aut-mei=真士 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=羽井佐実 kn-aut-sei=羽井佐 kn-aut-mei=実 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高岡宗徳 kn-aut-sei=高岡 kn-aut-mei=宗徳 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=伴秀利 kn-aut-sei=伴 kn-aut-mei=秀利 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=上塚大一 kn-aut-sei=上塚 kn-aut-mei=大一 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大川尚臣 kn-aut-sei=大川 kn-aut-mei=尚臣 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=河島留一 kn-aut-sei=河島 kn-aut-mei=留一 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=白川靖博 kn-aut-sei=白川 kn-aut-mei=靖博 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=繁光薫 kn-aut-sei=繁光 kn-aut-mei=薫 aut-affil-num=9 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山辻知樹 kn-aut-sei=山辻 kn-aut-mei=知樹 aut-affil-num=10 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=11 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　消化器・腫瘍外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　消化器・腫瘍外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　消化器・腫瘍外科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　消化器・腫瘍外科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　消化器・腫瘍外科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　消化器・腫瘍外科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　消化器・腫瘍外科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　消化器・腫瘍外科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　消化器・腫瘍外科学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　消化器・腫瘍外科学 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　消化器・腫瘍外科学 affil-num=12 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　消化器・腫瘍外科学 en-keyword=TNF kn-keyword=TNF en-keyword=IFN-α kn-keyword=IFN-α en-keyword=Apoptosis kn-keyword=Apoptosis en-keyword=NF-κB kn-keyword=NF-κB en-keyword=Fas kn-keyword=Fas END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=3 article-no= start-page=193 end-page=198 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=シナプス小胞エンドサイトーシスの制御機構に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=吉田祐美 kn-aut-sei=吉田 kn-aut-mei=祐美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 脳神経制御学 en-keyword=エンドサイトーシス kn-keyword=エンドサイトーシス en-keyword=ダイナミン kn-keyword=ダイナミン en-keyword=アンフィファイジン kn-keyword=アンフィファイジン END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=2 article-no= start-page=119 end-page=125 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=In vivo, Real Time Visualization of the Interaction between Perialveolar Microcirculation and Individual Alveolar Respiration　by CCD Videomicroscopy in Rats kn-title=ペンシル型CCD 生体顕微鏡システムを用いたin vivo肺微小循環と肺胞呼吸の同時可視化 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We succeeded in visualizing in vivo perialveolar microcirculation and individual alveolar respiration in rats,by our high resolution intravital charge-coupled device videomicroscopy system. To elucidate the relevance and usefullness of our methods, we investigated their behavior 1) under control conditions, 2) during increased tidal volumes (TV), 3)during positive-end expiratory pressure (PEEP) application, and 4)during exposure to hypoxia. We recognized a sheet-like flow pattern in capillaries, and observed semi-collapsed capillaries at end-inspiration while flow continued.The latter indicate existence of“vascular waterfall phenomenon”.When TV was increased from 2.5 to 5ml, the alveolar size was increased from 30±10 to 65±18μm (n＝21, p＜0.05), and the red blood cell velocities in perialveolar capillary were significantly decreased from 910±210 to 290±140μm/sec (n＝21,p＜0.05). Following PEEP application with TV of 5ml,the alveolar diameter was increased even more to 80±20μm (n＝12,p＜0.05)and the flows of microvessels stopped temporarily at end-inspiration.We also visualized that precapillary arterioles clearly constricted from 34±6 to 28±6μm in response to hypoxia (n＝9, p＜0.05). In conclusion, the intravital pencil lens-probe videomicroscopy can be a powerful tool for in vivo observation of perialveolar microcirculation and alveolar respiration under important physiological conditions such as changing TV, application of PEEP, and exposure to hypoxia. en-copyright= kn-copyright= en-aut-name=MorimotoTaro en-aut-sei=Morimoto en-aut-mei=Taro kn-aut-name=森本太郎 kn-aut-sei=森本 kn-aut-mei=太郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科システム循環生理学 en-keyword=肺微小循環 (pulmonary microcirculation) kn-keyword=肺微小循環 (pulmonary microcirculation) en-keyword=Waterfall 現象 (waterfall phenomenon) kn-keyword=Waterfall 現象 (waterfall phenomenon) en-keyword=低酸素性肺血管収縮 (pulmonary hypoxic vasoconstriction) kn-keyword=低酸素性肺血管収縮 (pulmonary hypoxic vasoconstriction) END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=3 article-no= start-page=229 end-page=234 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=気管支喘息における高分解能CT (high-resolution computed tomography) による評価の有用性―岡山大学医学賞（砂田賞）を受賞して― en-subtitle= kn-subtitle= en-abstract= kn-abstract=気管支喘息は気道の慢性炎症性疾患であり, 本質的に可逆性障害と考えられるが, 持続的慢性炎症によって生ずる肺実質を含む気道の器質的変化すなわち気道リモデリングが原因で不可逆性気流制限をきたし得ることが知られている. 最近, 高分解能CT (HRCT; high-resolution computed tomography) によって気管支壁肥厚, 気管支拡張, 気腫化, モザイク状低吸収域などの変化の評価が可能であることが報告されている. 気管支喘息患者の気道壁は健常者に比較して肥厚しており, その肥厚の程度は喘息の重症度, 気流制限, 気道反応性に関連していることが明らかになっている. 気道リモデリングを反映するHRCTの異常所見は, 慢性気流制限を有する重症喘息患者においてしばしば認められ, 長期の罹病期間や強い気道炎症と関係するとされている. 我々は, HRCTにおける-950Hounsfield unit (HU) 以下のlow attenuation area (RA(950)) は非喫煙喘息患者においても検出され, 気流制限, 肺気量, 喘息の重症度と相関しているが, 肺拡散能との有意の相関は認めないことを報告してきた. 最近, フラクタル解析によってRA(950)は, 喫煙歴を有する喘息患者では気腫性変化を示すのに対し, 非喫煙喘息患者では非気腫性変化 (過膨張) を示す可能性を示した. さらに, HRCTによって評価された気道壁肥厚およびRA950は, 治療によって改善することが認められており, HRCTは喘息の治療効果判定に有用である可能性が示唆された. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　老年医学 en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=高分解能CT kn-keyword=高分解能CT en-keyword=low attenuation area kn-keyword=low attenuation area en-keyword=気管支壁肥厚 kn-keyword=気管支壁肥厚 en-keyword=気道リモデリング kn-keyword=気道リモデリング END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=2 article-no= start-page=127 end-page=133 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Two cases of adult onset Schonlein-Henoch purpura with gastrointestinal manifestations kn-title=Schönlein-Henoch 紫斑病による腹痛症を呈し，内視鏡所見を観察しえた成人男性の２例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We describe two cases of adult-onset Schonlein-Henoch purpura with gastrointestinal manifestations. Case 1: A 73-year-old man was admitted to our hospital because of abdominal pain, diarrhea and fever. On physical examination, the abdomen was normal, and there were many palpable petechial hemorrhages on the lower extremities.Skin biopsy revealed infiltrations of lymphocytes, neutrophils and eosinophils into the dermis. A computed tomographic (CT) scan of the abdomen disclosed thickening of the intestinal wall in the duodenum and jejunum.Upper gastrointestinal fiberscopy revealed petechiation on the stomach and erosions on the duodenum. Case 2: A 54-year-old man was admitted to our hospital because of hematochezia.The patient had pharyngitis 4 days before admission, and his serum anti-streptolysion O level was increased.On physical examination, there were faint purpuras on the lower extremities.Skin biopsy revealed a histological image of leukocytoclastic vasculitis. A CT scan of the abdomen disclosed thickening of the intestinal wall in the duodenum, jejunum and ileum.Gastrointestinal fiberscopy revealed petechiation on the stomach and ulceration on the cecum. en-copyright= kn-copyright= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name=岩室雅也 kn-aut-sei=岩室 kn-aut-mei=雅也 aut-affil-num=1 ORCID= en-aut-name=OhyaShogen en-aut-sei=Ohya en-aut-mei=Shogen kn-aut-name=大家昌源 kn-aut-sei=大家 kn-aut-mei=昌源 aut-affil-num=2 ORCID= en-aut-name=YoshiokaMasao en-aut-sei=Yoshioka en-aut-mei=Masao kn-aut-name=吉岡正雄 kn-aut-sei=吉岡 kn-aut-mei=正雄 aut-affil-num=3 ORCID= en-aut-name=NasuTatsuyo en-aut-sei=Nasu en-aut-mei=Tatsuyo kn-aut-name=那須達世 kn-aut-sei=那須 kn-aut-mei=達世 aut-affil-num=4 ORCID= en-aut-name=OgawaTsuneyoshi en-aut-sei=Ogawa en-aut-mei=Tsuneyoshi kn-aut-name=小川恒由 kn-aut-sei=小川 kn-aut-mei=恒由 aut-affil-num=5 ORCID= en-aut-name=ItoMamoru en-aut-sei=Ito en-aut-mei=Mamoru kn-aut-name=伊藤守 kn-aut-sei=伊藤 kn-aut-mei=守 aut-affil-num=6 ORCID= en-aut-name=IshiyamaShuhei en-aut-sei=Ishiyama en-aut-mei=Shuhei kn-aut-name=石山修平 kn-aut-sei=石山 kn-aut-mei=修平 aut-affil-num=7 ORCID= en-aut-name=FujiwaraAkiko en-aut-sei=Fujiwara en-aut-mei=Akiko kn-aut-name=藤原明子 kn-aut-sei=藤原 kn-aut-mei=明子 aut-affil-num=8 ORCID= en-aut-name=ShiodeJunji en-aut-sei=Shiode en-aut-mei=Junji kn-aut-name=塩出純二 kn-aut-sei=塩出 kn-aut-mei=純二 aut-affil-num=9 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name=山本和秀 kn-aut-sei=山本 kn-aut-mei=和秀 aut-affil-num=10 ORCID= en-aut-name=ItoshimaTatsuya en-aut-sei=Itoshima en-aut-mei=Tatsuya kn-aut-name=糸島達也 kn-aut-sei=糸島 kn-aut-mei=達也 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山済生会総合病院内科 affil-num=2 en-affil= kn-affil=岡山済生会総合病院内科 affil-num=3 en-affil= kn-affil=岡山済生会総合病院内科 affil-num=4 en-affil= kn-affil=岡山済生会総合病院内科 affil-num=5 en-affil= kn-affil=岡山済生会総合病院内科 affil-num=6 en-affil= kn-affil=岡山済生会総合病院内科 affil-num=7 en-affil= kn-affil=岡山済生会総合病院内科 affil-num=8 en-affil= kn-affil=岡山済生会総合病院内科 affil-num=9 en-affil= kn-affil=岡山済生会総合病院内科 affil-num=10 en-affil= kn-affil=岡山済生会総合病院内科 affil-num=11 en-affil= kn-affil=岡山済生会総合病院内科 en-keyword=Schonlein-Henoch 紫斑病 (Schonlein-Henoch purpura) kn-keyword=Schonlein-Henoch 紫斑病 (Schonlein-Henoch purpura) en-keyword=アレルギー性紫斑病 (allergic purpura) kn-keyword=アレルギー性紫斑病 (allergic purpura) en-keyword=消化管内視鏡検査 (gastrointestinal fiberscopy) kn-keyword=消化管内視鏡検査 (gastrointestinal fiberscopy) en-keyword=成人 (adult-onset) kn-keyword=成人 (adult-onset) END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=3 article-no= start-page=199 end-page=204 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ヒストンアセチル化制御による実験的関節炎の抑制 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西田圭一郎 kn-aut-sei=西田 kn-aut-mei=圭一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 人体構成学 en-keyword=関節リウマチ kn-keyword=関節リウマチ en-keyword=エピジェネティクス kn-keyword=エピジェネティクス en-keyword=ヒストン脱アセチル化酵素阻害剤 kn-keyword=ヒストン脱アセチル化酵素阻害剤 en-keyword=CDKインヒビター kn-keyword=CDKインヒビター en-keyword=抗II型コラーゲン抗体誘導関節炎 kn-keyword=抗II型コラーゲン抗体誘導関節炎 END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=3 article-no= start-page=235 end-page=244 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ペルオキシソームの機能とペルオキシソーム病 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=石川哲也 kn-aut-sei=石川 kn-aut-mei=哲也 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田中ゆき kn-aut-sei=田中 kn-aut-mei=ゆき aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部保健学科　検査技術科学専攻機能解折学講座 affil-num=2 en-affil= kn-affil=岡山大学医学部保健学科　検査技術科学専攻機能解折学講座 en-keyword=細胞内小器官 kn-keyword=細胞内小器官 en-keyword=ペルオキシソーム kn-keyword=ペルオキシソーム en-keyword=ペルオキシソーム病 kn-keyword=ペルオキシソーム病 en-keyword=酸化酵素 kn-keyword=酸化酵素 END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=3 article-no= start-page=245 end-page=250 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=肺悪性腫瘍のラジオ波治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=金澤右 kn-aut-sei=金澤 kn-aut-mei=右 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　放射線医学 en-keyword=肺悪性腫瘍 kn-keyword=肺悪性腫瘍 en-keyword=ラジオ波治療 kn-keyword=ラジオ波治療 en-keyword=熱 kn-keyword=熱 en-keyword=凝固壊死 kn-keyword=凝固壊死 en-keyword=CT kn-keyword=CT END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=3 article-no= start-page=251 end-page=255 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=West 症候群の薬物療法 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大塚頌子 kn-aut-sei=大塚 kn-aut-mei=頌子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　発達神経病態学 en-keyword=West症候群 kn-keyword=West症候群 en-keyword=点頭てんかん kn-keyword=点頭てんかん en-keyword=薬物療法 kn-keyword=薬物療法 en-keyword=予後 kn-keyword=予後 END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=3 article-no= start-page=205 end-page=209 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Ubiquitin/Proteasome経路を介した核内受容体turnoverにおけるSuppressor for Gal-1の役割 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=増山寿 kn-aut-sei=増山 kn-aut-mei=寿 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部 産科婦人科学 en-keyword=suppressor for gal-1 kn-keyword=suppressor for gal-1 en-keyword=turnover kn-keyword=turnover en-keyword=proteasome kn-keyword=proteasome en-keyword=nuclear receptor kn-keyword=nuclear receptor en-keyword=endocrine disrupting chemicals kn-keyword=endocrine disrupting chemicals END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=3 article-no= start-page=257 end-page=260 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of hemorrhage from the colon diverticulum successfully treated by transcatheter arterial embolization kn-title=経カテーテル動脈塞栓術にて止血しえた大腸憩室出血の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We describe a case of hemorrhage from the colon diverticulum successfully treated by transcatheter arterial embolization. A 64-year-old man, who had been diagnosed with diabetes mellitus but not treated, was seen at our hospital on January 24, 1998 because of anal bleeding. Emergent colonoscopy revealed multiple diverticula at the cecum and ascending colon, one of which was the bleeding point. We tried to stop the bleeding at that time, but failed. Considering the poor risk for laparotomy, we performed a transcatheter arterial embolization. We embolized a marginal artery over about 4 cm by two coils and achieved hemostasis. In conclusion, the technique of a transcatheter arterial embolization is effective for diverticular bleeding especially in the case of a high risk patient. en-copyright= kn-copyright= en-aut-name=TakashimaSeiki en-aut-sei=Takashima en-aut-mei=Seiki kn-aut-name=高嶋成輝 kn-aut-sei=高嶋 kn-aut-mei=成輝 aut-affil-num=1 ORCID= en-aut-name=ManoMasayuki en-aut-sei=Mano en-aut-mei=Masayuki kn-aut-name=間野正之 kn-aut-sei=間野 kn-aut-mei=正之 aut-affil-num=2 ORCID= en-aut-name=NishiHideyuki en-aut-sei=Nishi en-aut-mei=Hideyuki kn-aut-name=西英行 kn-aut-sei=西 kn-aut-mei=英行 aut-affil-num=3 ORCID= en-aut-name=FukudaKazuma en-aut-sei=Fukuda en-aut-mei=Kazuma kn-aut-name=福田和馬 kn-aut-sei=福田 kn-aut-mei=和馬 aut-affil-num=4 ORCID= en-aut-name=KomatsubaraSyokiti en-aut-sei=Komatsubara en-aut-mei=Syokiti kn-aut-name=小松原正吉 kn-aut-sei=小松原 kn-aut-mei=正吉 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山労災病院　外科 affil-num=2 en-affil= kn-affil=岡山労災病院　外科 affil-num=3 en-affil= kn-affil=岡山労災病院　外科 affil-num=4 en-affil= kn-affil=岡山労災病院　外科 affil-num=5 en-affil= kn-affil=岡山労災病院　外科 en-keyword=大腸憩室出血 kn-keyword=大腸憩室出血 en-keyword=動脈塞栓術 kn-keyword=動脈塞栓術 END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=3 article-no= start-page=211 end-page=217 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=骨軟部腫瘍診断と治療における近年の進歩 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=尾﨑敏文 kn-aut-sei=尾﨑 kn-aut-mei=敏文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 整形外科学 en-keyword=骨軟部腫瘍 kn-keyword=骨軟部腫瘍 en-keyword=治療 kn-keyword=治療 en-keyword=生存率 kn-keyword=生存率 en-keyword=機能再建 kn-keyword=機能再建 END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=3 article-no= start-page=261 end-page=271 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=②医療の制度経営論／持続可能性の観点から診る医療保険制度改革 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西田在賢 kn-aut-sei=西田 kn-aut-mei=在賢 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=武蔵野大学大学院 en-keyword=医療保険 kn-keyword=医療保険 en-keyword=国民医療費 kn-keyword=国民医療費 en-keyword=総保健医療支出 kn-keyword=総保健医療支出 en-keyword=経営持続性 kn-keyword=経営持続性 en-keyword=疾病別医療資金管理 kn-keyword=疾病別医療資金管理 END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=3 article-no= start-page=273 end-page=279 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=泌尿器科における難治性感染症「尿路バイオフィルム感染症」 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=門田晃一 kn-aut-sei=門田 kn-aut-mei=晃一 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=公文裕巳 kn-aut-sei=公文 kn-aut-mei=裕巳 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　泌尿器病態学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　泌尿器病態学 en-keyword=尿路感染症 kn-keyword=尿路感染症 en-keyword=細菌バイオフィルム kn-keyword=細菌バイオフィルム en-keyword=院内感染 kn-keyword=院内感染 END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=2 article-no= start-page=89 end-page=96 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=石灰沈着を伴うび漫性神経原線維変化病における α-Synuclein 陽性病変から分かること―岡山大学医学賞（新見賞）を受賞して― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=横田修 kn-aut-sei=横田 kn-aut-mei=修 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=寺田整司 kn-aut-sei=寺田 kn-aut-mei=整司 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=石津秀樹 kn-aut-sei=石津 kn-aut-mei=秀樹 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=黒田重利 kn-aut-sei=黒田 kn-aut-mei=重利 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　精神神経病態学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　精神神経病態学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　精神神経病態学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　精神神経病態学 en-keyword=α-synuclein kn-keyword=α-synuclein en-keyword=diffuse neurofibrillary tangles with calcification kn-keyword=diffuse neurofibrillary tangles with calcification en-keyword=NAC kn-keyword=NAC en-keyword=synucleinopathy kn-keyword=synucleinopathy en-keyword=tauopathy kn-keyword=tauopathy END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=3 article-no= start-page=287 end-page=292 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=多剤耐性結核と肺非結核性抗酸菌症 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=谷本安 kn-aut-sei=谷本 kn-aut-mei=安 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=佐久川亮 kn-aut-sei=佐久川 kn-aut-mei=亮 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=木浦勝行 kn-aut-sei=木浦 kn-aut-mei=勝行 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=谷本光音 kn-aut-sei=谷本 kn-aut-mei=光音 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　血液・腫瘍・呼吸器内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　血液・腫瘍・呼吸器内科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　血液・腫瘍・呼吸器内科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　血液・腫瘍・呼吸器内科学 en-keyword=多剤耐性結核菌 kn-keyword=多剤耐性結核菌 en-keyword=DOTS kn-keyword=DOTS en-keyword=非結核性抗酸菌 kn-keyword=非結核性抗酸菌 en-keyword=MAC 症 kn-keyword=MAC 症 en-keyword=M. kansasii 症 kn-keyword=M. kansasii 症 END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=2 article-no= start-page=97 end-page=101 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=動脈硬化発生に関わる血管内皮細胞のナノ／マイクロメカニクス解析―岡山大学医学賞 （砂田賞） を受賞して― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=片岡則之 kn-aut-sei=片岡 kn-aut-mei=則之 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=橋本謙 kn-aut-sei=橋本 kn-aut-mei=謙 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=梶谷文彦 kn-aut-sei=梶谷 kn-aut-mei=文彦 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院歯学総合研究科　システム循環生理学 affil-num=2 en-affil= kn-affil=岡山大学大学院歯学総合研究科　システム循環生理学 affil-num=3 en-affil= kn-affil=岡山大学大学院歯学総合研究科　システム循環生理学 en-keyword=動脈硬化 kn-keyword=動脈硬化 en-keyword=血管内皮細胞 kn-keyword=血管内皮細胞 en-keyword=単球 kn-keyword=単球 en-keyword=ナノ／マイクロメカニクス kn-keyword=ナノ／マイクロメカニクス END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=3 article-no= start-page=219 end-page=224 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Characterization and usefulness of a monoclonal antibody against human herpesvirus-7 DNA polymerase processivity factor kn-title=ヒトヘルペスウイルス7型のDNA ポリメラーゼサブユニットに対する単クローン抗体の性状と有用性 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A monoclonal antibody (MAb), IK17, was developed and found useful for the analysis of human herpesvirus-7 (HHV7) genome replication. In Western blot analysis, the MAb IK17 specifically detected an HHV7 DNA polymerase subunit,U27 protein,expressed in both Escherichia coli (E.Coli)and HHV7-infected cells.Analysis by the same method of truncated U27 proteins expressed in E. Coli demonstrated that the MAb IK17 recognizes an epitope between amino acid 1 and 133 of the U27 protein.The indirect immunofluorescence (IF)method with MAb IK17 detected an unexpected reduction of U27 protein in the infected cells that were treated with a viral DNA polymerase inhibitor,phosphonoacetic acid (PAA),although no reduction of U27 mRNA was observed in the cells by Northern blot analysis. The data suggest the possible usefulness of the MAb IK17 for obtaining clues to characterize an unknown feature of the U27 protein. Immunoprecipitation experiments with the MAb IK17 enabled to detect at least four U27 protein-associated phosphorylated polypeptides in addition to the U27 protein itself.The result indicates the usefulness of the MAb IK17 for qualitative and quantitative analysis of the U27 proteinassociated viral and cellular factors. These analyses contribute to elucidation of the HHV7 genome replication system. en-copyright= kn-copyright= en-aut-name=NambaHikaru en-aut-sei=Namba en-aut-mei=Hikaru kn-aut-name=難波ひかる kn-aut-sei=難波 kn-aut-mei=ひかる aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 病原ウイルス学 en-keyword=ヒトヘルペスウイルス7型 (Human Herpesvirus-7) kn-keyword=ヒトヘルペスウイルス7型 (Human Herpesvirus-7) en-keyword=DNA polymerase processivity factor kn-keyword=DNA polymerase processivity factor en-keyword=単クローン抗体 (monoclonal antibody) kn-keyword=単クローン抗体 (monoclonal antibody) END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=2 article-no= start-page=103 end-page=107 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Ⅱ型 DNAトポイソメラーゼと神経細胞分化 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=筒井公子 kn-aut-sei=筒井 kn-aut-mei=公子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　神経機能構造学 en-keyword=Ⅱ型DNAトポイソメラーゼ kn-keyword=Ⅱ型DNAトポイソメラーゼ en-keyword=神経細胞分化 kn-keyword=神経細胞分化 en-keyword=遺伝子発現誘導 kn-keyword=遺伝子発現誘導 en-keyword=初代培養 kn-keyword=初代培養 en-keyword=シナプスタンパク質 kn-keyword=シナプスタンパク質 END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue=2 article-no= start-page=87 end-page=93 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ヒスタミンのIL-18産生誘導とIL-18誘導性免疫反応への関与―岡山大学医学賞（結城賞）を受賞して― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高橋英夫 kn-aut-sei=高橋 kn-aut-mei=英夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科機能制御学講座薬理学 en-keyword=Human kn-keyword=Human en-keyword=Monocytes/ Macrophages kn-keyword=Monocytes/ Macrophages en-keyword=T Lymphocytes kn-keyword=T Lymphocytes en-keyword=Cytokines kn-keyword=Cytokines END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=3 article-no= start-page=225 end-page=234 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=医療における個人情報保護法 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=太田吉夫 kn-aut-sei=太田 kn-aut-mei=吉夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 医療情報部 en-keyword=個人情報 kn-keyword=個人情報 en-keyword=個人情報保護 kn-keyword=個人情報保護 en-keyword=プライバシー kn-keyword=プライバシー en-keyword=医療情報 kn-keyword=医療情報 END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=2 article-no= start-page=117 end-page=123 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Direct in vivo observation of coronary capillaries with a high resolution CCD intravital videomicroscope kn-title=高倍率CCD生体顕微鏡システムによる 心拍動 下冠毛細血管の直接観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We visualized the epicardial capillary network of the beating canine heart in vivo, using our high resolution intravital CCD videomicroscopy system, in order to elucidate its functional role under control conditions and during reactive hyperemia (RH). We used 10 hearts of open chest, anesthetized dogs. The pencil-lens videomicroscope probe was placed over capillaries fed by the left anterior descending artery in A-V blocked hearts paced at 60-90 beats per minute. In individual capillaries under control conditions flow was predominant either during systole or during diastole, indicating that the watershed between diastolic arterial and systolic venous flows is located within capillaries. The capillary flow increased rapidly during RH and reached a peak flow-velocity (2.0 ± 0.2 mm/s), twice as high as the control flow-velocity (1.0 ± 0.3 mm/s), with enhancement of intercapillary cross-connection flow. Furthermore, the mean diameter increased by 15% compared with the control value, additionally facilitating oxygen supply to myocardial cells, but there was a time lag of about 1.5 s for refilling the capillaries, indicating their function as capacitance vessels during RH. In conclusion, the coronary capillary network functions as 1) the major watershed between diastolic-dominant arterial and systolic-dominant venous flows, 2) a capacitor, and 3) a local flow amplifier and homogenizer of blood supply during RH. en-copyright= kn-copyright= en-aut-name=KiyookaTakahiko en-aut-sei=Kiyooka en-aut-mei=Takahiko kn-aut-name=清岡崇彦 kn-aut-sei=清岡 kn-aut-mei=崇彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　循環器内科 en-keyword=冠微小循環 kn-keyword=冠微小循環 en-keyword=分水嶺 kn-keyword=分水嶺 en-keyword=unstressed volume kn-keyword=unstressed volume END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue=2 article-no= start-page=101 end-page=108 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The role of overhead in the treatment of developmental dislocation of the hip:The evaluation of the position of the femoral head and the limbus shape kn-title=先天性股関節脱臼に対する overhead traction 法の効果―大腿骨頭に位置および関節唇形態の変化― en-subtitle= kn-subtitle= en-abstract= kn-abstract=The role of overhead traction in the treatment of development al dislocation of the hip, using two-directional srthrography before and after overhead traction,in 56 hips (47 patients) was investigated. There were 5 males (6 hips) and 42 females (50 hips). Of the 56 hips, 41 were treated before walking age and 15 after walking age. The age at the time of overhead traction ranged from 5 to 22 months (average 9 months). Mau'soriginal traction method was used in 38 hips from 1974 to 1988 and Ishida's modified method in 18 hips from 1989 to 2000, but the results were poorer with the former method. Reduction of the femoral head was considered to be obtained when it moved to the entrance of the acetabulum after overhead traction (19 of 41 hips). The shapes of the anterior and posterior portions of the limbus were corrected in 8 of 52 hips, especially in the cases treated before walking age. The superior portion of the linbus was uncharnged. According to the appearance on images, modifind overhead traction appeared to be effective in achieving reduction, but could not comoletely correct the limbus shape. en-copyright= kn-copyright= en-aut-name=MatsudaKazumi en-aut-sei=Matsuda en-aut-mei=Kazumi kn-aut-name=松田和実 kn-aut-sei=松田 kn-aut-mei=和実 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Study of Biofunctional Recovery and Reconstruction Science of Functional Recovery and Reconstruction Okayama University Graduate School of Medicine and Dentistry en-keyword=先天性股関節脱臼 kn-keyword=先天性股関節脱臼 en-keyword=overhead牽引 kn-keyword=overhead牽引 en-keyword=関節造影 kn-keyword=関節造影 en-keyword=整復 kn-keyword=整復 END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=2 article-no= start-page=149 end-page=155 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=①　医療の経営学とは／Introductory Health Policy and Management en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西田在賢 kn-aut-sei=西田 kn-aut-mei=在賢 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=武蔵野大学大学院 en-keyword=Health Policy and Management kn-keyword=Health Policy and Management en-keyword=制度経営 kn-keyword=制度経営 en-keyword=事業経営 kn-keyword=事業経営 en-keyword=経営持続性 kn-keyword=経営持続性 END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue=2 article-no= start-page=119 end-page=123 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of adult Meckel's diveticul um with gastrointestinal bleeding kn-title=下血を主訴として発見された成人 Meckel 憩室に1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Gastrointestinal bleeding is often intermittent and its souree may be difficult to locate, resulting in delay of definitve diagnosis. Melena usually denotes bleeding not only from the upper, and lower gastrointestine but from the small int estine. Adult Meckel's diverticulum with gastrointestinal beeding is a relatively rare disease and often presents difficulty in preoperative diagnosis. A 65-year-old man was admitted to our hospital due to melena. Upper and lower gastrointestional endoscopy revealed no bleeding stie. (99m)Tc-pertechnetate scintigraphy is well known as a useful tool for preoperative delineation of Meckel's diverticulm. (99m)Tc-pertechnetate scintigraphy was performed in this patient and succesfully depicted the lesion noninvasively. In surgery, Meckel's diverticulum was found at an oral stie 90 cm from the terminalileum, and a sleevereseection was performed. Histopathologically, the diver ticulum had ectopic gastric muco sa and two 5mm ulcers on the border of the gastric mucosa. en-copyright= kn-copyright= en-aut-name=MorimotoYoshinori en-aut-sei=Morimoto en-aut-mei=Yoshinori kn-aut-name=守本芳典 kn-aut-sei=守本 kn-aut-mei=芳典 aut-affil-num=1 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博己 kn-aut-sei=岩垣 kn-aut-mei=博己 aut-affil-num=2 ORCID= en-aut-name=MorishitaNorio en-aut-sei=Morishita en-aut-mei=Norio kn-aut-name=森下紀夫 kn-aut-sei=森下 kn-aut-mei=紀夫 aut-affil-num=3 ORCID= en-aut-name=NakagawaHitoshi en-aut-sei=Nakagawa en-aut-mei=Hitoshi kn-aut-name=中川仁志 kn-aut-sei=中川 kn-aut-mei=仁志 aut-affil-num=4 ORCID= en-aut-name=MatsubaraNagahide en-aut-sei=Matsubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=5 ORCID= en-aut-name=IsozakiHiroshi en-aut-sei=Isozaki en-aut-mei=Hiroshi kn-aut-name=磯崎博司 kn-aut-sei=磯崎 kn-aut-mei=博司 aut-affil-num=6 ORCID= en-aut-name=KajiEisuke en-aut-sei=Kaji en-aut-mei=Eisuke kn-aut-name=加地英輔 kn-aut-sei=加地 kn-aut-mei=英輔 aut-affil-num=7 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=8 ORCID= en-aut-name=MizunoMotoo en-aut-sei=Mizuno en-aut-mei=Motoo kn-aut-name=水野元夫 kn-aut-sei=水野 kn-aut-mei=元夫 aut-affil-num=9 ORCID= en-aut-name=ShiratoriYasushi en-aut-sei=Shiratori en-aut-mei=Yasushi kn-aut-name=白鳥康史 kn-aut-sei=白鳥 kn-aut-mei=康史 aut-affil-num=10 ORCID= en-aut-name=TnakaNoriaki en-aut-sei=Tnaka en-aut-mei=Noriaki kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・肝臓・感染症内科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・肝臓・感染症内科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・肝臓・感染症内科学 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・肝臓・感染症内科学 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科 en-keyword=下血 kn-keyword=下血 en-keyword=成人 kn-keyword=成人 en-keyword=Meckel憩室 kn-keyword=Meckel憩室 en-keyword=異所性胃粘膜 kn-keyword=異所性胃粘膜 en-keyword=99mTc-pertechnetateシンチグラフィ kn-keyword=99mTc-pertechnetateシンチグラフィ END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=2 article-no= start-page=163 end-page=167 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=難治性の深在性真菌症を発症した子宮頚癌再発患者の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=水谷靖司 kn-aut-sei=水谷 kn-aut-mei=靖司 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平松祐司 kn-aut-sei=平松 kn-aut-mei=祐司 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　産科・婦人科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　産科・婦人科 en-keyword=難治性感染症 kn-keyword=難治性感染症 en-keyword=深在性真菌症 kn-keyword=深在性真菌症 en-keyword=易感染性宿主 kn-keyword=易感染性宿主 en-keyword=日和見感染 kn-keyword=日和見感染 en-keyword=抗真菌剤 kn-keyword=抗真菌剤 END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=1 article-no= start-page=1 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=神経シナプスにおけるエンドサイトーシス機能タンパク質‐膜リン脂質 相互作用機序の人工脂質膜を用いた解析法―岡山大学医学賞（新見賞）を受賞して― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=絹田正裕 kn-aut-sei=絹田 kn-aut-mei=正裕 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　脳神経制御学 en-keyword=endocytosis kn-keyword=endocytosis en-keyword=synaptic vesicle kn-keyword=synaptic vesicle en-keyword=liposome kn-keyword=liposome en-keyword=dynamic light scattering kn-keyword=dynamic light scattering en-keyword=phospholipids kn-keyword=phospholipids END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=1 article-no= start-page=9 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=心不全における酸化ストレスの関与：基礎的ならびに臨床的検討 ―岡山大学医学賞（結城賞）を受賞して― en-subtitle= kn-subtitle= en-abstract= kn-abstract=心不全患者において血中の過酸化脂質の上昇などが報告され，活性酸素による酸化ストレスの関与が示唆されている．そこで，心筋が実際に活性酸素を発生するかどうかを，活性酸素を検出する蛍光プローブを用いてラットの培養心筋細胞において検討した．心不全増悪因子であるアンジオテンシンIIおよびtumor necrosis factor(TNF)-alphaを加えると心筋細胞で濃度依存性に活性酸素が発生した．さらにヒトの不全心筋においても実際に酸化ストレスの発生が増強しているかを検討した．過酸化脂質の代謝産物で，有害なアルデヒドである4-Hydroxy-2-nonenal(HNE)によって修飾された蛋白質を免疫染色にて調べたところ，拡張型心筋症患者の心筋において正常心機能者に比べ5倍以上増加していた．さらにβ遮断薬(Carvedilol)により治療を行ったところ心機能の改善とともに，HNE修飾蛋白質が40%低下した．以上の一連の研究により， 活性酸素による酸化ストレスの発生が不全心筋において増強しており，その抑制が心不全治療のターゲットの一つになりうることを明らかにした． en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中村一文 kn-aut-sei=中村 kn-aut-mei=一文 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=草野研吾 kn-aut-sei=草野 kn-aut-mei=研吾 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=垣下幹夫 kn-aut-sei=垣下 kn-aut-mei=幹夫 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三浦綾 kn-aut-sei=三浦 kn-aut-mei=綾 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=久松研一 kn-aut-sei=久松 kn-aut-mei=研一 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西井伸洋 kn-aut-sei=西井 kn-aut-mei=伸洋 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=伴場主一 kn-aut-sei=伴場 kn-aut-mei=主一 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡邊敦之 kn-aut-sei=渡邊 kn-aut-mei=敦之 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤尾栄起 kn-aut-sei=藤尾 kn-aut-mei=栄起 aut-affil-num=9 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=宮地克維 kn-aut-sei=宮地 kn-aut-mei=克維 aut-affil-num=10 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=永瀬聡 kn-aut-sei=永瀬 kn-aut-mei=聡 aut-affil-num=11 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=森田宏 kn-aut-sei=森田 kn-aut-mei=宏 aut-affil-num=12 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=斎藤博則 kn-aut-sei=斎藤 kn-aut-mei=博則 aut-affil-num=13 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=江森哲郎 kn-aut-sei=江森 kn-aut-mei=哲郎 aut-affil-num=14 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=浅沼幹人 kn-aut-sei=浅沼 kn-aut-mei=幹人 aut-affil-num=15 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=宮崎正博 kn-aut-sei=宮崎 kn-aut-mei=正博 aut-affil-num=16 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中村陽一 kn-aut-sei=中村 kn-aut-mei=陽一 aut-affil-num=17 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松原広己 kn-aut-sei=松原 kn-aut-mei=広己 aut-affil-num=18 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=伏見和郎 kn-aut-sei=伏見 kn-aut-mei=和郎 aut-affil-num=19 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=豊國伸哉 kn-aut-sei=豊國 kn-aut-mei=伸哉 aut-affil-num=20 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大江透 kn-aut-sei=大江 kn-aut-mei=透 aut-affil-num=21 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　循環器内科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　循環器内科 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　循環器内科 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　循環器内科 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　循環器内科 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　循環器内科 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　循環器内科 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　循環器内科 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　循環器内科 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　循環器内科 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　循環器内科 affil-num=12 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　循環器内科 affil-num=13 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　循環器内科 affil-num=14 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　循環器内科 affil-num=15 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　神経情報学 affil-num=16 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　細胞生物学 affil-num=17 en-affil= kn-affil=松山市民病院循環器内科 affil-num=18 en-affil= kn-affil=国立病院岡山医療センター循環器科 affil-num=19 en-affil= kn-affil=北陸先端科学技術大学院大学ナノマテリアルテクノロジーセンター affil-num=20 en-affil= kn-affil=京都大学大学院医学研究科病態生物医学 affil-num=21 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　循環器内科 en-keyword=4-Hydroxy-2-nonenal kn-keyword=4-Hydroxy-2-nonenal en-keyword=酸化ストレス kn-keyword=酸化ストレス en-keyword=心不全 kn-keyword=心不全 en-keyword=β遮断薬 kn-keyword=β遮断薬 END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue=2 article-no= start-page=145 end-page=150 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=神経内視鏡を用いた脳神経外科手術 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松井利浩 kn-aut-sei=松井 kn-aut-mei=利浩 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=伊達勲 kn-aut-sei=伊達 kn-aut-mei=勲 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院　医歯学総合研究科　神経病態外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院　医歯学総合研究科　神経病態外科学 en-keyword=neuroendoscope kn-keyword=neuroendoscope en-keyword=neurosurgery kn-keyword=neurosurgery en-keyword=hydrocephalus kn-keyword=hydrocephalus en-keyword=third ventriculostomy kn-keyword=third ventriculostomy en-keyword=biopsy kn-keyword=biopsy END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=1 article-no= start-page=17 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Parkinson's disease from a viewpoint of regenerative medicine kn-title=再生医学から見たパーキンソン病 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It has long been considered that central nervous system would not regenerate after injury, but this concept has recently been changing due to the development of neuroscience research. Cell grafting, gene transfer and neurotrophic factor administration into the brain and spinal cord are the examples of methods to perform protection and repair. These techniques are expected to be applied to certain neurological disorders such as Parkinson's disease, cerebral ischemia and spinal cord injury. Parkinson's disease is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the nigrostriatal system. Fetal neurons, chromaffin cells, cell lines, certain genes, neural stem cells, ES cells and bone marrow cells have been investigated as donor cells and vectors to treat Parkinson's disease. This review will summarize the history of neural transplantation in Parkinson's disease and features and prospects of each donor will be discussed. en-copyright= kn-copyright= en-aut-name=DateIsao en-aut-sei=Date en-aut-mei=Isao kn-aut-name=伊達勲 kn-aut-sei=伊達 kn-aut-mei=勲 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　神経病態外科学 en-keyword=Parkinson's disease kn-keyword=Parkinson's disease en-keyword=neural transplantation kn-keyword=neural transplantation en-keyword=regeneration kn-keyword=regeneration END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue=2 article-no= start-page=155 end-page=159 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=気管支喘息 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=金廣有彦 kn-aut-sei=金廣 kn-aut-mei=有彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院　第二内科 END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=1 article-no= start-page=29 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=医学教育概説―教育評価とその運用― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=板谷裕子 kn-aut-sei=板谷 kn-aut-mei=裕子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=全国共同利用施設岐阜大学医学部医学教育開発センター　MEDC （Medical Education Development Center） en-keyword=Medical education kn-keyword=Medical education en-keyword=Concept formation kn-keyword=Concept formation en-keyword=Insight leaning kn-keyword=Insight leaning en-keyword=Medical interview kn-keyword=Medical interview en-keyword=Tutorial kn-keyword=Tutorial END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue=1 article-no= start-page=1 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050530 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=クロマティン暗号解明と疾患治療への応用（CREB/CBPをアンカーとして）－Arthritis Investigator Award Hulda Irene Duggan Arthritis Investigator Award を受賞して－ en-subtitle= kn-subtitle= en-abstract= kn-abstract=それぞれがノーベル賞の対象となったGプロテイン, サイクリックAMP, プロテインカイネースAという細胞内シグナル情報伝達メインストリームの遺伝子発現における最終的なゴールが転写因子CREB (サイクリックAMPレスポンスエレメント結合タンパク) だった. CREB研究はさらに, 世界で初めての転写因子のリン酸化による遺伝子発現機構の証明, そのシグナル依存的なコアクテイベーターの発見と, いよいよ全貌が明らかとなってきた基本転写因子と外界からのシグナルの接合調節メカニズムの解明においても常に分子生物学をリードしてきた. 我々はCREB研究を通し, クロマテインを加味した新しい遺伝子発現機構を解明し, さらには遺伝子治療, 再生医療への応用において, 最先端の分子生物学と臨床医学をまっすぐに結ぶストラテジーとなりうることを示してきた. 丁度, 打腱器のようにCREBをツールとして使い, その生体内情報系を震わせてやることで, CREB周辺の組織特異的なモレキュラーメカニズムが次々と明らかになってきている. ポストゲノム時代の溢れかえる分子情報のノイズの波に押し流されないためのアンカーとして, そしてサイエンスにおける次のパラダイムの扉をあける鍵として, 古くて新しいCREBそしてクロマテイン研究を, 私たちの研究を中心に紹介したい. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=浅原弘嗣 kn-aut-sei=浅原 kn-aut-mei=弘嗣 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部整形外科 en-keyword=クロマティン kn-keyword=クロマティン en-keyword=転写制御 kn-keyword=転写制御 en-keyword=慢性関節リウマチ kn-keyword=慢性関節リウマチ END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue=3 article-no= start-page=203 end-page=210 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Morphological study of the limbus in dysplastic hips kn-title=臼蓋形成不全股における関節唇形態の研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In dysplastic hips, concentration of the weight and load on the lateral peripheral limbus causes its detachment and tearing, which is an important risk factor of coxarthrosis. Arthrograms of 77 hip joins in 40 patients (all female) with dysplastic hips were used to analyze the covering of the acetabulum and limbus. The average age at the time of arthrograms was 26 years (13-48). The limbus covering angle, a supplement to the CE angle, was added to the CE angle to measure the femoral head cover. Our results demonstrated a negative correlation between the degree of acetabular dysplasia and the length of the limbus. Insufficient bony acetabulums tended to be accompanied by proportionally longer limbi. Also, the limbus was significantly longer in cases with tears, suggesting that a long and unstable limbus might be more likely to undergo tearing, thereby increasing the risk of coxarthrosis. en-copyright= kn-copyright= en-aut-name=IshihamaTakuo en-aut-sei=Ishihama en-aut-mei=Takuo kn-aut-name=石濱琢央 kn-aut-sei=石濱 kn-aut-mei=琢央 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Okayama University Graduate School of Medicine and Dentistry Science of Functional Recovery and Reconstruction en-keyword=hip joint kn-keyword=hip joint en-keyword=acetabular dysplasia kn-keyword=acetabular dysplasia en-keyword=limbus kn-keyword=limbus en-keyword=arthrography kn-keyword=arthrography END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=1 article-no= start-page=39 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The long-term follow-up study of Colonna capsular arthroplasty for developmental dislocation of the hip kn-title=先天性股関節脱臼に対するColonna法術後の股関節機能維持期間および股関節症発症時期に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The long-term follow-up study of Colonna capsular arthroplasty for developmental dislocation of the hip, especially in terms of duration of the hip function and the onset of coxarthrosis, was investigated. There were 68 hips (63 patients, 54 female and 9 male). The age at the time of the surgery ranged from 11 months to 12 years and 9 months (average 4 years and 3 months). According to the Kaplan-Meier's method, the average survival rate of the hip function was 25 years and 8 months and the survival rate for 25 years was 53%, if the end point was defined as the time hip pain began. Then the average survival rate of hip function was 28 years and the rate was 60.3%, if the end point was defined as the time radiograph showed advanced stage. Clinically, the hip function, especially walking ability, proved to be maintained for long time. The long-term result was worse, when the operation was performed when the patient was older than 6 years old or when patient had previous treatment. en-copyright= kn-copyright= en-aut-name=NagayasuTaisuke en-aut-sei=Nagayasu en-aut-mei=Taisuke kn-aut-name=永易大典 kn-aut-sei=永易 kn-aut-mei=大典 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　整形外科学 en-keyword=先天性股関節脱臼 kn-keyword=先天性股関節脱臼 en-keyword=Colonna法 kn-keyword=Colonna法 en-keyword=生存分析 kn-keyword=生存分析 END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue=1 article-no= start-page=9 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050530 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=プロアクロシン結合タンパク sp32 前駆体のヒトホモログ遺伝子の同定とがん・精巣 (CT) 抗原－岡山大学医学賞（林原賞）を受賞して－ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小野俊朗 kn-aut-sei=小野 kn-aut-mei=俊朗 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　免疫学 en-keyword=OY-TES-1 kn-keyword=OY-TES-1 en-keyword=sp32 kn-keyword=sp32 en-keyword=Cancer/testis（CT）antigen kn-keyword=Cancer/testis（CT）antigen en-keyword=Sperm protein kn-keyword=Sperm protein en-keyword=Cancer kn-keyword=Cancer END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue=1 article-no= start-page=15 end-page=19 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050530 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Relationship between formation of HCV-bearing immune complexes and response to inteferon therapy for chroic hepatitis C kn-title=C型慢性肝炎におけるHCV-免疫複合体形成とインターフェロン治療効果との関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We retrospectively analyzed the relationship between formation of HCV-bearing immune complexes (HCV-IC) and response to interferon (IFN) therapy for chronic hepatitis C (CH-C). Five CH-C patients with complete response (CR) to IFN therapy and pre-treatment HCV RNA titer measured by Amplicor HCV-monitor and five stage (biopsy proved fibrosis of the liver)-matiched CH-C patients who were non-esponders (NR) to IFN therapy were enrolled. Pretretment sera were separated into HCV-IC (supernatant) and anti-HCV antibody-free virions (pellet) by addition of anti-human immunoglobulins and centrifugation. HCV RNA was quantified in the supernatant and the pellet, by real-time PCR and semi-quantitative RT-PCR respectively. There were discrepancies in the HCV RNA titers measured by Amplicor and the results of real-time PCR. We found a larges quantity of HCV RNA in the supernatan and a smaller quantity in the pellet in CR than in NR by using by real-time PCR. Our data indicate that response to interferon therapy for CH-C patients may be associated with the conditions underlying the formation of HCV-IC. en-copyright= kn-copyright= en-aut-name=ManabeRyouji en-aut-sei=Manabe en-aut-mei=Ryouji kn-aut-name=眞鍋良二 kn-aut-sei=眞鍋 kn-aut-mei=良二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry en-keyword=HCV kn-keyword=HCV en-keyword=chronic hepatitisC kn-keyword=chronic hepatitisC en-keyword=HCV-immune complexes kn-keyword=HCV-immune complexes END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue=1 article-no= start-page=21 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050530 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Radiographic changes of proximal tibia and patella after high tibial osteotomy for knee osteoarthitis kn-title=変形性膝関節症における高位脛骨骨切り術後の骨変化－脛骨近位部と膝蓋骨に生じる単純Ｘ線写真上の輝度変化－ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Radiographic brightness was measured in the proximal tibia and patella of 57 knees before and after high tibial osteotomy (HTO) for osteoarthritis. The brightness was converted to the thickness of a reference Aluminum phantom using NIH Image software. The knees were classified into 4 groups according to the position of the point at which the mechanical axis of the leg intersects the tibial articular surface after HTO, namely "overcorrected" (the position; lateral 0～25%), "adequately corrected" (mid lateral 25～50%), "undercorrected" (mid medial 50～75%), and "correction failure" (medial 75%～). Brightness was high in the lateral and central regions of the proximal tibia in the adequately corrected group, while that of the lateral loading region was high in the overcorrected group. The brightness was broadly high in the undercorrected group, and was not distinct in the correction failure group. In the patella, the brightness of the lateral region was higher than that of the medial region before HTO, and the difference between the two regions was considerably reduced in the adequately corrected group. These findings indicate that adequate correction of leg alignment causes favorable changes in the patellofemoral joint as well as in the femorotibial joint. en-copyright= kn-copyright= en-aut-name=HondaToru en-aut-sei=Honda en-aut-mei=Toru kn-aut-name=本田透 kn-aut-sei=本田 kn-aut-mei=透 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Department of Orthopaedic Surgery, Okayama University Medical School en-keyword=High tibial osteotomy kn-keyword=High tibial osteotomy en-keyword=densitometory kn-keyword=densitometory en-keyword=tibia kn-keyword=tibia en-keyword=patella kn-keyword=patella en-keyword=osteoarthritis kn-keyword=osteoarthritis END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue=1 article-no= start-page=33 end-page=37 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050530 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An autopsy case of death after trauma in an elderly subject with pulmonary squamous cell carcinoma From the viewpoint of forensic medicine in an aging society kn-title=外傷後死亡した肺扁平上皮癌を有する高齢者の1部検例－高齢化時代を迎えつつある法医学の立場から－ en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this study, we experienced a case of an elderly man with clinically undiagnosed squamous cell carcinoma of the lung, who died 8 days after a trauma. This case was autopsied because of a question over the causal association between the trauma and death. From the autopsy findings, it was judged that respiratory and metabolic abnormalities due to lung cancer were exacerbated by trauma, and that medically the cause of death should be assessed as death by disease. en-copyright= kn-copyright= en-aut-name=IshikawaTakaki en-aut-sei=Ishikawa en-aut-mei=Takaki kn-aut-name=石川隆紀 kn-aut-sei=石川 kn-aut-mei=隆紀 aut-affil-num=1 ORCID= en-aut-name=FurusatoMasakuni en-aut-sei=Furusato en-aut-mei=Masakuni kn-aut-name=古里征国 kn-aut-sei=古里 kn-aut-mei=征国 aut-affil-num=2 ORCID= en-aut-name=YoshitomeKei en-aut-sei=Yoshitome en-aut-mei=Kei kn-aut-name=吉留敬 kn-aut-sei=吉留 kn-aut-mei=敬 aut-affil-num=3 ORCID= en-aut-name=MiyaishiSatoru en-aut-sei=Miyaishi en-aut-mei=Satoru kn-aut-name=宮石智 kn-aut-sei=宮石 kn-aut-mei=智 aut-affil-num=4 ORCID= en-aut-name=IshizuHideo en-aut-sei=Ishizu en-aut-mei=Hideo kn-aut-name=石津日出雄 kn-aut-sei=石津 kn-aut-mei=日出雄 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科法医学分野 affil-num=2 en-affil= kn-affil=杏林大学医学部病理学教室 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯学総合研究科法医学分野 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯学総合研究科法医学分野 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯学総合研究科法医学分野 en-keyword=高齢化 kn-keyword=高齢化 en-keyword=肺癌 kn-keyword=肺癌 en-keyword=法医学 kn-keyword=法医学 END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue=1 article-no= start-page=40 end-page=44 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050530 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=1. らせんＣＴ検診による微小肺癌の診断 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西井研治 kn-aut-sei=西井 kn-aut-mei=研治 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=玄馬顕一 kn-aut-sei=玄馬 kn-aut-mei=顕一 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=瓦家正志 kn-aut-sei=瓦家 kn-aut-mei=正志 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岸野大蔵 kn-aut-sei=岸野 kn-aut-mei=大蔵 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小谷剛士 kn-aut-sei=小谷 kn-aut-mei=剛士 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山県健康づくり財団附属病院 affil-num=2 en-affil= kn-affil=岡山労災病院呼吸器科 affil-num=3 en-affil= kn-affil=岡山県健康づくり財団附属病院 affil-num=4 en-affil= kn-affil=岡山県健康づくり財団附属病院 affil-num=5 en-affil= kn-affil=岡山県健康づくり財団附属病院 en-keyword=らせんCT kn-keyword=らせんCT en-keyword=肺癌検診 kn-keyword=肺癌検診 en-keyword=微小肺癌 kn-keyword=微小肺癌 END start-ver=1.4 cd-journal=joma no-vol=114 cd-vols= no-issue=3 article-no= start-page=243 end-page=251 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=肝臓を標的とした細胞療法 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KobayashiNaoya en-aut-sei=Kobayashi en-aut-mei=Naoya kn-aut-name=小林直哉 kn-aut-sei=小林 kn-aut-mei=直哉 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=興津輝 kn-aut-sei=興津 kn-aut-mei=輝 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=都津川敏範 kn-aut-sei=都津川 kn-aut-mei=敏範 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=丸山昌伸 kn-aut-sei=丸山 kn-aut-mei=昌伸 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小坂芳和 kn-aut-sei=小坂 kn-aut-mei=芳和 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=荒田尚司 kn-aut-sei=荒田 kn-aut-mei=尚司 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小林和也 kn-aut-sei=小林 kn-aut-mei=和也 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=野口洋文 kn-aut-sei=野口 kn-aut-mei=洋文 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大橋一郎 kn-aut-sei=大橋 kn-aut-mei=一郎 aut-affil-num=9 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=国枝武美 kn-aut-sei=国枝 kn-aut-mei=武美 aut-affil-num=10 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=柴田憲邦 kn-aut-sei=柴田 kn-aut-mei=憲邦 aut-affil-num=11 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=武居道彦 kn-aut-sei=武居 kn-aut-mei=道彦 aut-affil-num=12 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=尾下瑞子 kn-aut-sei=尾下 kn-aut-mei=瑞子 aut-affil-num=13 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=林伸幸 kn-aut-sei=林 kn-aut-mei=伸幸 aut-affil-num=14 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中路修平 kn-aut-sei=中路 kn-aut-mei=修平 aut-affil-num=15 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大元謙二 kn-aut-sei=大元 kn-aut-mei=謙二 aut-affil-num=16 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=倉林譲 kn-aut-sei=倉林 kn-aut-mei=譲 aut-affil-num=17 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山本晋一郎 kn-aut-sei=山本 kn-aut-mei=晋一郎 aut-affil-num=18 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=19 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　消化器・腫瘍外科 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kn-affil=岡山赤十字病院呼吸器内科 affil-num=3 en-affil= kn-affil=岡山赤十字病院呼吸器内科 affil-num=4 en-affil= kn-affil=岡山赤十字病院呼吸器内科 affil-num=5 en-affil= kn-affil=岡山赤十字病院呼吸器内科 en-keyword=気管支閉塞 kn-keyword=気管支閉塞 en-keyword=ステント kn-keyword=ステント en-keyword=bronchial intervention kn-keyword=bronchial intervention END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue=1 article-no= start-page=63 end-page=68 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050530 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=重度急性呼吸器症候群SARS en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=木浦勝行 kn-aut-sei=木浦 kn-aut-mei=勝行 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=谷本安 kn-aut-sei=谷本 kn-aut-mei=安 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田端雅弘 kn-aut-sei=田端 kn-aut-mei=雅弘 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=金廣有彦 kn-aut-sei=金廣 kn-aut-mei=有彦 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=上岡博 kn-aut-sei=上岡 kn-aut-mei=博 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=谷本光音 kn-aut-sei=谷本 kn-aut-mei=光音 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=渡邊都貴子 kn-aut-sei=渡邊 kn-aut-mei=都貴子 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=草野展周 kn-aut-sei=草野 kn-aut-mei=展周 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小出典男 kn-aut-sei=小出 kn-aut-mei=典男 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院　第二内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院　第二内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院　第二内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院　第二内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院　第二内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院　第二内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院　中央検査部 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院　中央検査部 en-keyword=SARS kn-keyword=SARS en-keyword=伝幡経路 kn-keyword=伝幡経路 en-keyword=対策 kn-keyword=対策 en-keyword=緊急報告 kn-keyword=緊急報告 END start-ver=1.4 cd-journal=joma no-vol=114 cd-vols= no-issue=3 article-no= start-page=253 end-page=259 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=癌抑制遺伝子 ING ファミリーの構造と機能 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=GunduzMehmet en-aut-sei=Gunduz en-aut-mei=Mehmet kn-aut-name=グンデウズメーメット kn-aut-sei=グンデウズ kn-aut-mei=メーメット aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医歯学総合研究科　病態機構学講座，口腔病理病態学分野 en-keyword=ING 1 kn-keyword=ING 1 en-keyword=ING 3 kn-keyword=ING 3 en-keyword=ING ファミリー kn-keyword=ING ファミリー en-keyword=癌抑制遺伝子 kn-keyword=癌抑制遺伝子 en-keyword=LOH kn-keyword=LOH END start-ver=1.4 cd-journal=joma no-vol=114 cd-vols= no-issue=2 article-no= start-page=117 end-page=123 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Ikaros family とリンパ系腫瘍 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中瀬浩一 kn-aut-sei=中瀬 kn-aut-mei=浩一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=愛媛県立中央病院 END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue=3 article-no= start-page=233 end-page=236 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=耳鼻咽喉科領域における内視鏡下鼻内手術 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=武田靖志 kn-aut-sei=武田 kn-aut-mei=靖志 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=竹内彩子 kn-aut-sei=竹内 kn-aut-mei=彩子 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=赤木成子 kn-aut-sei=赤木 kn-aut-mei=成子 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小川晃弘 kn-aut-sei=小川 kn-aut-mei=晃弘 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山赤十字病院 耳鼻咽喉科 affil-num=2 en-affil= kn-affil=岡山赤十字病院 耳鼻咽喉科 affil-num=3 en-affil= kn-affil=岡山赤十字病院 耳鼻咽喉科 affil-num=4 en-affil= kn-affil=姫路聖マリア病院 耳鼻咽喉科 en-keyword=慢性副鼻腔炎手術の歴史 kn-keyword=慢性副鼻腔炎手術の歴史 en-keyword=鼻内法 (endonasal approach) kn-keyword=鼻内法 (endonasal approach) en-keyword=endoscopic sinus Surgery (ESS) kn-keyword=endoscopic sinus Surgery (ESS) en-keyword=osteomeatal complex (OMC) kn-keyword=osteomeatal complex (OMC) en-keyword=マイクロデブリッダー kn-keyword=マイクロデブリッダー END start-ver=1.4 cd-journal=joma no-vol=114 cd-vols= no-issue=2 article-no= start-page=125 end-page=130 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ＳＥＲＥＸ法によるマウス移植腫瘍の抗原解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小野俊朗 kn-aut-sei=小野 kn-aut-mei=俊朗 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　免疫学 en-keyword=SEREX kn-keyword=SEREX en-keyword=Meth A kn-keyword=Meth A en-keyword=Mouse kn-keyword=Mouse en-keyword=Antibody kn-keyword=Antibody en-keyword=Cancer/testis (CT) anigen kn-keyword=Cancer/testis (CT) anigen END start-ver=1.4 cd-journal=joma no-vol=114 cd-vols= no-issue=3 article-no= start-page=261 end-page=266 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=死体肺移植における一酸化窒素吸入（NO）の有効性と至適投与時間についての実験的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=肺移植の普及と共に,ドナー不足は深刻な問題となっています.もし心停止ドナーからの肺の使用が可能ならば,ドナーの増加に大きく寄与するものと思われます.しかしながら死体肺移植に関しては,温阻血時間に伴う術後早期の移植肺機能不全が,大きな問題になると予想されます.今回私達は,死体肺移植において,温阻血時間の延長及び呼吸機能の改善に対する一酸化窒素(NO)吸入の有効性と,更にその至適投与時間についての実験的検討を行いました.雑種成犬を用い,ドナーをヘパリン化することなく,心停止後3時間室温にて放置の後,左片肺移植を行いました.移植後対側肺動脈及び気管支を結紮し,移植肺機能を6時間評価しました.100%酸素換気下に,再潅流直前より評価終了時までNO40ppmを持続吸入した群(group 1, n=6),評価開始後1時間までNO40ppmを持続吸入,以後終了時まで,Saturationを一致させるために,窒素40ppmを同じく持続吸入した群(group 2, n=6)及び,再潅流直前より評価終了時まで,窒素を持続吸入した群(group 3,n=6)とを比較検討しました.生存時間,動脈血酸素分圧(PaO(2)),動脈血二酸化炭素分圧(PaCO(2)),湿乾燥重量比(W/D ratio),気道内の吸引量の結果より,NO吸入により虚血再潅流障害軽減による呼吸機能の改善並びに,肺水腫の抑制が示唆されました.またmyeloperoxidase activity (MPO)の有意な低下と,肺血管抵抗(PVR)の低下が認められました. group 1とgroup 2の間には,これらの結果について特に有意な差は認めませんでした.従って,NO吸入が,死体肺移植において,温阻血時間の延長及び呼吸機能の改善に対し有効であり,しかも再潅流直前より短期間の吸入で持続吸入と同様の効果が得られるものと思われます. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高嶋成輝 kn-aut-sei=高嶋 kn-aut-mei=成輝 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=伊達洋至 kn-aut-sei=伊達 kn-aut-mei=洋至 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=青江基 kn-aut-sei=青江 kn-aut-mei=基 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山下素弘 kn-aut-sei=山下 kn-aut-mei=素弘 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=安藤陽夫 kn-aut-sei=安藤 kn-aut-mei=陽夫 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=清水信義 kn-aut-sei=清水 kn-aut-mei=信義 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学第２外科 affil-num=2 en-affil= kn-affil=岡山大学第２外科 affil-num=3 en-affil= kn-affil=岡山大学第２外科 affil-num=4 en-affil= kn-affil=岡山大学第２外科 affil-num=5 en-affil= kn-affil=岡山大学第２外科 affil-num=6 en-affil= kn-affil=岡山大学第２外科 END start-ver=1.4 cd-journal=joma no-vol=114 cd-vols= no-issue=1 article-no= start-page=1 end-page=4 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020530 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=私たちの導電染色と導電樹脂―山陽新聞賞を受賞して― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MurakamiTakuro en-aut-sei=Murakami en-aut-mei=Takuro kn-aut-name=村上宅郎 kn-aut-sei=村上 kn-aut-mei=宅郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科人体構成学 END start-ver=1.4 cd-journal=joma no-vol=114 cd-vols= no-issue=2 article-no= start-page=131 end-page=132 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=職業性ストレスの健康影響とその対策 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=川上憲人 kn-aut-sei=川上 kn-aut-mei=憲人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究所　衛生学・予防医学分野 END start-ver=1.4 cd-journal=joma no-vol=114 cd-vols= no-issue=3 article-no= start-page=267 end-page=274 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=スーパーマイクロサージャリーを用いた形成再建外科 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=光嶋勲 kn-aut-sei=光嶋 kn-aut-mei=勲 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　形成再建外科 END start-ver=1.4 cd-journal=joma no-vol=114 cd-vols= no-issue=1 article-no= start-page=5 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020530 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=腹臥位呼吸管理とARDSの治療戦略上の意義 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=氏家良人 kn-aut-sei=氏家 kn-aut-mei=良人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科生体制御科学専攻・機能制御学講座（救急医学） en-keyword=ARDS kn-keyword=ARDS en-keyword=腹臥位 kn-keyword=腹臥位 en-keyword=EBM kn-keyword=EBM en-keyword=有効性 kn-keyword=有効性 END start-ver=1.4 cd-journal=joma no-vol=114 cd-vols= no-issue=2 article-no= start-page=133 end-page=138 dt-received= dt-revised= dt-accepted= dt-pub-year=2002 dt-pub=20020930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A study on thr effect of Heliobacter pylori to the gastric mucosal defensive mechanism kn-title=Helicobacter pylori の胃粘膜防御機構に与える影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=UDP-galactosyltransferase (UDP-Gal-T) is a key enzyme in the synthesis of mucus glycoproteins, which play an important role in gastric mucosal defensive mechanisms. Helicobacter pylori (HP) induces gastritis and peptic ulceers but mechanisms of HP-induced mucosal injury sre not fully understood. To elucidate the mechanism whereby (HP) infection induces gastric mucosal injury, we investigated the effects HP on the gastric mucosal defensive mechanism by measuring UDP-Gal T activies in HGC-27, a mucin-producing gastric caneer cell line, treated with　various HP-relatd materials (sonicated HP, HP culture supernatants, live HP). HP-related materials induced no significant chages in UDP-Gal T activity, but the enzyme increased when we generated a low concentration of ammonia by adding sonicated HP. and urea simultaneousy. In contrast, UDP-Gal-T activity did not increase when we added live HP instead of sonicated HP. Next, we investigated the effects of HP on ethanol-induced injury in the HGC-27 cells. Pretreatment with ammonia of a low concetration significantly protected cells from ethanol-induced injury. In contrast, pretreatment with live HP and urea generated ammonia of the similar concentration but did not protect cells from the injoy. Our findings that HP has an inhibitory effect against adaptive cytoprotection induced by ammonia by inhibiting the induction of UDP-Gal T. en-copyright= kn-copyright= en-aut-name=YoshinagaFumiya en-aut-sei=Yoshinaga en-aut-mei=Fumiya kn-aut-name=吉永文哉 kn-aut-sei=吉永 kn-aut-mei=文哉 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry en-keyword=Helicobacter pylori kn-keyword=Helicobacter pylori en-keyword=UDP-galactosyltansferase kn-keyword=UDP-galactosyltansferase en-keyword=ammonia kn-keyword=ammonia en-keyword=ethanol kn-keyword=ethanol en-keyword=adaptive cytoprotection kn-keyword=adaptive cytoprotection END