start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=489 end-page=506 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Clinicohistological Study of Bleeding Mechanism in Myomata of the Uterus kn-title=子宮筋腫の出血機序に関する臨床的研究並びに内膜血管の組織学的及び形態学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Genital bleeding as a main symptome of myoma of the uterus is not uncommonly encountered by gynecologist. Clinical and histological studies were carried on both entdometria and ovaries of 24 patients with myoma of the uterus. Specific attention was paid to clarify the bleeding mechanism from this diease, using histological and transparently modeled specimens of the blood vessels. The transparent specimens were made as follows. After hysterectomy was done, a pigment solution was injected into the vessels and then, after an adequate dehydration, the specimens were trausferred to methylsalcilate for immersion. The binocular stereomicroscope was used for the present study. Results of the study are summarized in the following. 1) Menstrual abnormality was found in 70,9% of all the cases. 2) The endometrial and ovarian histology has the same cyclic changes as the normal does, and the endometrial secretory phase is compatible with the corpus luteam in the ovary. 3) The majority of cases showed endometrial hyperplasia. 4) In case of submucous myomata, a striking difference of the endometrial thickness and the histologic pictures between the surface endometria above the myomata and the other areas. 5) The blood vessels of myomatous endometria have the same cycle as those of the normal do. Although the intramuscular blood vessels in influenced by the myomata mass, there is no specific morphological changes found in the endometrial blood vessels. 6) In this study, no venous sinus was observed in the endometrium. 7) It would appear that the menstrual abnormality under myoma of the uterus may be caused by the mechanical effect from the myomatous mass upon the endometrial and myometrial vessels. en-copyright= kn-copyright= en-aut-name=SeoTakashi en-aut-sei=Seo en-aut-mei=Takashi kn-aut-name=瀬尾貴 kn-aut-sei=瀬尾 kn-aut-mei=貴 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産科婦人科学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=507 end-page=513 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Transaminase of Brain (I) Transaminase Activities of the Monkey and Human Brain kn-title=脳のトランスアミナーゼ 第1編 タイワンザル脳およびヒト脳におけるトランスアミナーゼ活性について en-subtitle= kn-subtitle= en-abstract=The author measured the transaminase activities of eighteen amino acids with α-keto-glutarate in a Pithecus monkey brain and in two human brains, one obtained from a man died from accident and another from a woman died of senile psychosis due to brain atrophy. 1. In the monkey brain, alanine and valine showed low activities in the cerebral cortex in comparison with other parts but γ-amino-β-hydroxybutyric acid showed a low activity. 2. In normal human brain, lower activities of valine, leucine and three ω-amino acids were showed in the cerebral cortex, which were different from the monkey and lower vertebrates. 3. The markedly atrophic cerebral cortex was more similar to the lower vertebrates than to the normal human brain in high activities of alanine, leucine, valine and γ-amino-β-hydroxybutyric acid. But an increase of activities of histidine, proline and ornithine was not similar to both of normal human and animal brain. These high activities of histidine and praline correspond unlikely to the transamination only. kn-abstract=タイワンザル脳,事故死ヒト脳の大脳皮質,大脳白質および小脳皮質,さらに高度の脳萎縮を伴い老人性痴呆にて死亡したヒト脳の大脳皮質を用い, 11種のα-アミノ酸, 3種のω-アミノ酸, 3種のヂアミノ酸,システイン酸,タウリンについて,組織のトランスアミナーゼ活性を測定した. 1. タイワンザル脳では,大脳皮質においてアラニンとバリンの活性が他部より低く,γ-アミノ酪酸とγ-アミノ-β-オキシ酪酸が高い. 2. 健常人脳では,アスパラギン酸,セリンが大脳皮質に,ヒスチジン,ロイシン,バリンが小脳皮質にて他部より高く,アラニン,フエニールアラニン,システイン酸は大脳白質において低い活性を示した. 3. タイワンザルおよび健常ヒト脳の大脳皮質では,いずれもアスパラギン酸,グリシン,フエニールアラニン,オルニチン,システイン酸の高い活性,およびアラニンの低い活性の点で他の下等動物脳と異なる. 4. 健常ヒト大脳皮質は,バリン,ロイシンおよび3種のω-アミノ酸の低い活性を以つてサルおよび下等動物と異なる. 5. 萎縮したヒト大脳皮質は,アラニン,ロイシン,バリン,γ-アミノ-β-オキシ酪酸の活性が健常ヒト大脳皮質より高く,むしろ下等動物のそれに近い.ヒスチジン,プロリン,オルニチンのグルタミン酸生成の著しい増加は健常ヒト脳および下等動物脳のいずれとも異なるが,ヒスチジンとプロリンはトランスアミナーゼ活性増加のみによるものかどうか疑わしい. en-copyright= kn-copyright= en-aut-name=OnoMasaya en-aut-sei=Ono en-aut-mei=Masaya kn-aut-name=小野昌也 kn-aut-sei=小野 kn-aut-mei=昌也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=1-3 article-no= start-page=297 end-page=316 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Treatment of Malignant Tumors With Fibroblasts Inhibiting Agents Basic and Clinical Studies of Chloroquine Derivatives. (1) kn-title=線維芽細胞抑制剤による悪性腫瘍の治療に関する研究 クロロキン剤の基礎と臨床(第一報) en-subtitle= kn-subtitle= en-abstract= kn-abstract=Followings are the results derived from the treatment of animal and human cancers with a fibroblasts inhibiting agent such as chloroquine, based on the unique idea of ours. 1). In implanted tumors of animals, the effect was noted in Bashford cancer and Brown-Pearce cancer relatively rich in connective tissue in terms of life prolongation, an inhibition of tumor growth and of decrease of liver catalase activity, an improvement of iron metabolism, an enlargement of necrotic area in histology, an inhibition of connective tissue conponents, and a decrease of acid mucopolysaccharides. A tendency for a decrease of amount and cell numbers of ascites was almost the only effect noted in Ehrlich cancer, Yoshida sarcoma, and MH 134 poor in connective tissue. 2). 75 cases of humau cancer were treated with this agent and among these 75 the effect was evaluated in 40 cases with definite histological diagnosis in respects with subjective and objective improvement. It was effective in 28 cases, resulted failure in 11 cases, and gave an obscure result in 1 case. Cases which were treated for more than 2m onths never resulted in therapeutic failure, indicating that the agent was somehow effective for all cases but those in the last stadium. In respect with organs involved, the effect was most prominent in lung cancer and urinary bladder cancer, somewhat less in gastric cancer, and often seen in carcinomatous peritonitis and many other advanced cancers. This effect was noted in a comparatively short period in terms of subjective improvement, regression in size of tumors in a number of cases, a decrease of serum lactic acid dehydrogenase, and improvement of general condition, a tendency for necrosis of tumor and an inhibition of interstitium. 3). The above results indicate that the agent is more effective for tumors rich in connective tissue and that it's secondary effect on tumors through the inhibition of interstitial connective tissue is considered as the operative mechanism of chloroquine against malignant tumors, but it's anti-inflammatory effect and generalized influence on hosts are to be taken into consideration. The agent is indicated in inoperable cases, postoperative relapse, or prior and following an operation. A search for stronger fibroblasts inhibiting agents and an evaluation of combined therapy with so called anti-cancer agents are being made and that with mitomycin C is giving a fairly promising result. en-copyright= kn-copyright= en-aut-name=HirakiKiyoshi en-aut-sei=Hiraki en-aut-mei=Kiyoshi kn-aut-name=平木潔 kn-aut-sei=平木 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=2 ORCID= en-aut-name=OtaZensuke en-aut-sei=Ota en-aut-mei=Zensuke kn-aut-name=太田善介 kn-aut-sei=太田 kn-aut-mei=善介 aut-affil-num=3 ORCID= en-aut-name=AsanoKenwo en-aut-sei=Asano en-aut-mei=Kenwo kn-aut-name=浅野健夫 kn-aut-sei=浅野 kn-aut-mei=健夫 aut-affil-num=4 ORCID= en-aut-name=KageyamaHiroshi en-aut-sei=Kageyama en-aut-mei=Hiroshi kn-aut-name=影山浩 kn-aut-sei=影山 kn-aut-mei=浩 aut-affil-num=5 ORCID= en-aut-name=ShibuyaKoichi en-aut-sei=Shibuya en-aut-mei=Koichi kn-aut-name=渋谷貢一 kn-aut-sei=渋谷 kn-aut-mei=貢一 aut-affil-num=6 ORCID= en-aut-name=KotaniHidenari en-aut-sei=Kotani en-aut-mei=Hidenari kn-aut-name=小谷秀成 kn-aut-sei=小谷 kn-aut-mei=秀成 aut-affil-num=7 ORCID= en-aut-name=MatsuuraRyozo en-aut-sei=Matsuura en-aut-mei=Ryozo kn-aut-name=松浦良三 kn-aut-sei=松浦 kn-aut-mei=良三 aut-affil-num=8 ORCID= en-aut-name=TsuchidaJunichiro en-aut-sei=Tsuchida en-aut-mei=Junichiro kn-aut-name=土田潤一郎 kn-aut-sei=土田 kn-aut-mei=潤一郎 aut-affil-num=9 ORCID= en-aut-name=SezakiTatsuo en-aut-sei=Sezaki en-aut-mei=Tatsuo kn-aut-name=瀬崎達雄 kn-aut-sei=瀬崎 kn-aut-mei=達雄 aut-affil-num=10 ORCID= en-aut-name=HiraokaToshinobu en-aut-sei=Hiraoka en-aut-mei=Toshinobu kn-aut-name=平岡敏延 kn-aut-sei=平岡 kn-aut-mei=敏延 aut-affil-num=11 ORCID= en-aut-name=HimeiHajime en-aut-sei=Himei en-aut-mei=Hajime kn-aut-name=姫井孟 kn-aut-sei=姫井 kn-aut-mei=孟 aut-affil-num=12 ORCID= en-aut-name=MoritaniYoshiaki en-aut-sei=Moritani en-aut-mei=Yoshiaki kn-aut-name=守谷欣明 kn-aut-sei=守谷 kn-aut-mei=欣明 aut-affil-num=13 ORCID= en-aut-name=YamanaMasatoshi en-aut-sei=Yamana en-aut-mei=Masatoshi kn-aut-name=山名正俊 kn-aut-sei=山名 kn-aut-mei=正俊 aut-affil-num=14 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=7 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=8 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=9 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=10 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=11 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=12 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=13 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=14 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=515 end-page=520 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Transaminase of Brain (U) Effects of Psychotropic and Neurotropic Drugs on the Transaminase Activities kn-title=脳のトランスアミナーゼ 第2編 各種向精神・神経薬のダイコクネズミ脳組織トランスアミナーゼ活性に及ぼす影響 en-subtitle= kn-subtitle= en-abstract=Effects of 18 psychotropic and 3 neurotropic drugs were measured by the author on the glutamic-aspartic transaminase (GAT) activities in the rat brain homogenates. 1. Chlorpromazine, chlopromazine sulfoxide, acetylpromazine, levomepromazine, mepazine and perphenazine inhibited GAT, while prochlorperazine showed no effect. Both of diethazine and promethazine did not effect on GAT. 2. Pipradrol and dimethylaminoethanol activated GAT, while methylphenidate showed no effect. 3. Azacyclonol, amobarbital, phenobarbital, methyprylon, glutethimide and primidone were inhibitory in acion on GAT. 4. LSD-25 inhibited to GAT and bemegride did not effect on. 5. In the effect on GAT, similarities of imipramine to the phenothiazine derived depressants, or differences of diethazine and promethazine from other phenothiazine derivatives seemed to be causad due to the resemble or different distance between two nitrogen atoms. kn-abstract=ダイコクネズミ脳homogenateを用い,グルタミン酸-アスパラギン酸トランスアミナーゼ(GAT)活性に及ぼす18種の向精神薬,および3種の向神経薬の影響を測定した. 1. フエノチアジン系向精神薬は, Prochlorperazineを除く他の6種はいずれもGAT阻害を示し,阻害作用はChlorpromazineに最も強かつた. Chlorpromazine S-oxideはChlorpromazineに比してGAT阻害作用は著しく弱い. 2種のフエノチアジン系向神経薬はGAT活性に影響をみなかつた. 2. AzacyclonolはGAT阻害を示し, LSD-25は高濃度で阻害を示したが低濃度では影響を与えなかつた. 3. 中枢刺戟剤4種のうち, PipradrolとDMAEは促進, Methylphenidateは影響なく, Tofranilは阻害を示した. 4. バルビツール酸系睡眠剤AmobarbitalとPhenobarbital,非バルビツール酸系睡眠剤MethyprylonとGlutethimideは,すべて阻害を示した.しかるにバルビツール酸拮抗剤BemegrideはGATに無影響であつた.抗てんかん剤Primidoneは阻害を示した. 5. 実験に用いた中枢抑制剤13種のうち12種が阻害を示した. 6. GATに及ぼす作用において, ImipramineとChlorpromazineの類似, DiethazineやPromethazineとChlorpromazineとの差異を,化学構造における2個のN原子間の距離の一致と相異に対応すると考えた. en-copyright= kn-copyright= en-aut-name=OnoMasaya en-aut-sei=Ono en-aut-mei=Masaya kn-aut-name=小野昌也 kn-aut-sei=小野 kn-aut-mei=昌也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=521 end-page=535 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Liver Biopsy Chapter 1. Correlations between Liver Biopsy Findings and Liver Function Tests in Infectious Hepatitis kn-title=肝生検に関する研究 第1編 流行性肝炎に於ける肝生検所見と肝機能検査成績との関係に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=35 cases of acute viral hapatitis and 60 cases of chronic hepatitis underwent needle liver biopsies, and the studies were made on the correlations between histological findings and liver function tests of these cases, and the following results were obtained. 1. In the preicteric and icteric stages of the acute viral hepatitis cases, cephalin cholesterol flocculation test, serum bilirubin and Azorubin-S excretion test presented closest correlations with histological findings of the liver. 2. In the convelescent stages of acute viral hepatitis, delayed recoveries were observed in Glisson's capsules and peripheral areas of the lobules rather than liver cells. in these cases, 63.3% of cephalin cholesterol flocculation test and Azorbin-S excretion test had mutual relations with histological pictures. 3. In the chronic hepatitis cases there was no evidence of close correlation between liver function tests and histological findings. 4. In the chronic hepatitis cases, in whom pseudolobules were formed histologically, hyperbilirubinemia, various serum colloid liver function tests and pigment excretion tests were all positive. 5. In the hepatitis type II (H. Eppinger) cases, a dissociation was observed between liver function tests and histological findings despite severe icterus and advanced impairment of the liver cells. en-copyright= kn-copyright= en-aut-name=UedaYutaka en-aut-sei=Ueda en-aut-mei=Yutaka kn-aut-name=植田胖 kn-aut-sei=植田 kn-aut-mei=胖 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=537 end-page=544 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Liver Biopsy Chapter 2. Studies on Bilifustin like Substance in the Liver and its Entity kn-title=肝生検に関する研究 第2編 肝臓内Bilifuscin様物質の検出とその本態に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A cases thought to be a I. N. Dubin & F, B. Johson's constitutional hemolytic icterus, a case with carcinoma of the stomach and a case with posthepatitic syndrome were described in this study. In the latter two cases, brown colored granules in the liver cells were noted. Studying these granules histochemically, in comparison with histochemical features of granules which were considered to bilifuscin or its analogous substance obtained following the administration of blood, verdohemoglobin and biliverdin into the subcutaneous tissues of mouse, these granules were not I. N. Dubin's lipofuscin like pigment but precipitation of bilifuscin in the liver cells stemmed from decomposition of bilirubin as results of abnormal bilirubin metabolism. en-copyright= kn-copyright= en-aut-name=UedaYutaka en-aut-sei=Ueda en-aut-mei=Yutaka kn-aut-name=植田胖 kn-aut-sei=植田 kn-aut-mei=胖 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学綿一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=545 end-page=552 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Histological Studies on Experimental Hepatitis Part 1. On the Histological Changes of the Internal Organs of Mouse Following the Oral Administrations of the Various Concentrations of Arsenious Acid kn-title=実験的肝炎の組織学的研究 第1編 種々な濃度の亜砒酸を経口投与した場合の体内諸臓器の組織学的変化に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing the histological changes of the internal organs of mouse following the oral administrations of 0.5 cc of arsenious acid in various concentrations, and the following results were obtained. 1. In the cases given 0.5 and 1.0% of arsenious acid orally, marked degenerations of the parenchymal cells ware observed mainly in the kidney and heart. But, vascular damages were present in every organ, especially evident in the liver and spleen; hypertrophy of stelliform cells, destruction, dilatation, hyperemia, swelling and roughness of the vascular walls. 2. In the cases given daily 0.05% arsenious acid orally, increased degenerations of the parenchymal cells in the kidney and heart, comparing with initial stadium, was noted. But, the similar vascular damages were observed in the organs especially in the liver and spleen. Moreover, the lymphatic spaces have been dilated progressively, and some serous exudates was seen in the lymphatic spaces of the liver on the 6 th day. 3. In the cases given daily 0.05% arsenious acid orally. nodules accompanied with diffuse infiltration of round cells were observed on the 6 th day. On the 7 th to 8 th day, there appeared coagulation necrosis in which central areas were almost full of polymorphnucleous leucocytes, stelliform cells and degenerative products from the liver cells. Small necrosis composed of lymphocytes and stelliform cells was seen on the 9 th to 10 th days. 4. As the histological changes of the mouse organs described above, were quite similar to those of the infectious hepatitis cases, this study would offer some suggestions to clarify the contributing factors in the pathology of infectious hepatitis. en-copyright= kn-copyright= en-aut-name=EndoKenichi en-aut-sei=Endo en-aut-mei=Kenichi kn-aut-name=遠藤憲一 kn-aut-sei=遠藤 kn-aut-mei=憲一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=553 end-page=560 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Histological Studies on Experimental Hepatitis Part 2. On the Histological Changes of the Internal Organs of Mouse Given Daily Small Dosis of Arsenious Acid Orally, with Ectromelia virus Infection kn-title=実験的肝炎の組織学的研究 第2編 亜砒酸少量連日投与廿日鼠にEetromelia virusを感染させた場合の体内諸臓器の組織学的変化について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing the histological changes of the internal organs of the mice, having daily oral administrations of arsenious acid and simultaneous oral infection of Ectromelia virus and of the mice infected Ectromelia virus 4 days after the beginning of the arsenious acid administration, in compared with those that had daily arsenious acid without the infection, and the following results were obtained. 1. In the cases had the continuous administration of arsenious acid administration, in compared with those that had daily arsenious acid without the infection, and the following results were obtained. In the liver of the same cases, degeneration and necrosis of the liver cells and nuclei were marked, on the other hand, regenerations of the liver cells in association with round cell infiltrations were noted. There were extensive parenchimal impairments in the kideny and heart as well. 2. In the cases with Ectromelia virus infection on the 4 th day after the beginning of the arsenious acid administration, much severe vascular damages, and degenerations and necrosis of the liver parenchyma especially marked in the peripheral areas of the lobules were observed There were more extensive parenchymal imparments in the kidney and heart. 3. The cases with both Ectromelia virus infection and the administration of the arsenic acid presented the pathological findings summed up both of damages but especially marked in the vascular regions. In the cases with viral infection following the arsenious acid intoxication, the vascular damages due to the intoxication gave some influences upon the further pathological changes. 4. The vascular damages caused by the arsenious acid intoxication appeared to be essentially similar to those of Ectromelia virus infections. en-copyright= kn-copyright= en-aut-name=EndoKenichi en-aut-sei=Endo en-aut-mei=Kenichi kn-aut-name=遠藤憲一 kn-aut-sei=遠藤 kn-aut-mei=憲一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=561 end-page=567 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Leukocyte Functions in Case of Liver Impairment Part 1. Motility and Phagocytosis of Leukocyte in Experimental Liver Impairment kn-title=肝障碍時に於ける白血球機能に関する研究 第1編 肝炎患者の白血球遊走速度並びに墨粒貪喰能に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing leukocyte motility and leukocyte phagocytosis of Indiaink on the infectious hepatitis cases, and the following results were obtained. 1. In the healthy individuals, the leukocyte motility was ranging over 22.05 to 35.71 μ/min. and 1.88 to 2.22 in the leukocyte phagocytosis of India-ink. 2. In the acute hepatitis cases, the leukocyte motility was depressed initially and was then accelated in the convalescent stadium. Leukocyte phagocytosis of India-ink showed similar tendencies although they were fairly variable in the clinical courses. 3. The both functions of leukocyte showed approximate correlations to the impairments of liver functions. 4. In the acute hepatitis cases, the both functions of leukocyte were depressed in almost parallel with fever and leukocytosis. 5. In the chronic hepatitis cases, the leukocyte motility was within normal range, however, the phagocytosis of India-ink was depressed in some cases. The leukocyte motility showed approximate correlation to the impairments of liver function, on the other hand, the phagocytosis of India-ink did not always showed such correlation. en-copyright= kn-copyright= en-aut-name=NishidaTakeshi en-aut-sei=Nishida en-aut-mei=Takeshi kn-aut-name=西田彪 kn-aut-sei=西田 kn-aut-mei=彪 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=317 end-page=329 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Weakening of Resistance of Isoniazid-Resistant Tubercle Bacilli, Catalase-Activity and Virulence Part T Study on Weakening of Resistance of Isoniazid-Resistant Tubercle Bacilli kn-title=INH耐性結核菌の耐性低下ならびにcatalase活性と毒力に関する研究 第1編 INH耐性結核菌の耐性低下に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to bring light to the mechanism of weakening of resistance to INH, the author cultured several generations of a perfect INH-resistant single colony of bacilli, conducted experiments on several generations of mixed population, further cultured generations of bacilli in a poorly fed culture medium and studied the change of population and thoroughly examined the factor in culture medium which has effects on the weakening of resistance. The results of the experiments observed were as follows: 1. No weakening of resistance could be observed in INH 10γ resistant strains obtained by one step, step by step cultured or by direct separation from patient if strains have been cultured in 1% KH(2)PO(4) medium. 2. No weakening of resistance could be observed by testing generations of strains, some of which were obtained by step by step culture and some by means of separation from patient, in a poorly fed culture medium. 3. According to the method of mixed population, the ratio of INH resistant bacilli contained therein decreased as generation of bacilli cultured in a 1% KH(2)PO(4) medium descends. 4. The ratio of INH resistant bacilli in mixed population cultured in a poorly fed medium rapidly decreased as generation descends compared to corresponding generation of bacilli cultured in 1% KH(2)PO(4) medium. However, the difference in viability between INH resistant bacilli and INH receptive bacilli cultured in a poorly fed medium could not be observed clearly. Neither could any mutagenic effect on the INH resistance of bacilli on a poorly fed culture medium be found. 5. Upon finding the rapid weakening of the resistance of INH resistant bacilli cultured in a poorly medium, the author prepared a glycerine lacking medium and also a sodium glutamine lacking medium and conducted experiments on generations of bacilli cultured in such mediums to determine the factors in the medium which cause the weakening. The author found that in the former case (glycerine lacking medium) weakening is delayed whereas in the latter case weakening process is observed promptly. It is presumed that INH resistant bacilli requires glutamic acid far more than INH receptive bacilli and that for that reason the growth of bacilli in a sodium glutamine lacking medium is delayed. en-copyright= kn-copyright= en-aut-name=NakataniAkira en-aut-sei=Nakatani en-aut-mei=Akira kn-aut-name=中谷照 kn-aut-sei=中谷 kn-aut-mei=照 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=569 end-page=579 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Leukocyte Functions in Case of Liver Impairment Part 2. Leukocyte Motility and Leukocyte Phagocytosis of Indiaink in Experimental Liver Impairment kn-title=肝障碍時に於ける白血球機能に関する研究 第2編 実験的肝障碍時の白血球遊走速度並びに墨粒貪喰能に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing leukocyte motility and leukocyte phagocytosis of India-ink in the two groups of cases, the one of the which had formic acid allyl for only once and the other had daily small dosis, and studying the effect to the motility and phagocytosis of leukocyte of various drugs for infectious hepatitis, and the following results were obtained. 1. Following the administration of formic acid allyl (30 mg/kg), the leukocyte motility was accelated within one hour and thereafter depressed abruptly. On the other hand, the phagocytosis of Indiaink have dicreased after giving formic acid allyl. Both functions of leukocyte depressed markedly in the cases given increased formic acid allyl up to 50 mg/kg. 2. Following the administration of formic acid allyl, no effect to the both functions by giving Cortisone, unclear by DOCA, and an accelation and regaining of the both fnnctions were noted by giving ACTH. Regaining of the motility, not of the phagocytosis, from depressed state and further accelation were observed following the administration of 5% dextrose in water. Ferric chlorophyll preparations had the leukocyte motility regained from depressed state following the administration of formic acid allyl of 30 mg/kg, but no effect was seen after 50 mg/kg of formic acid allyl. There was no effect by ferric chlorophyll. Glucuronic acid showed a transient effect do leukocyte motility, but not to the phagocytosis of India-ink. 3. The both functions of leukocyte have markedly depressed, the maximum at 9th day in the cases who had been having formic acid allyl 10 mg/kg for 4 days. 4. In the above cases a slight improvement to the both functions of leukocyte was seen by giving Cortisone or DOCA, a distinctive improvement, on the other hand, by ACTH. 5% dextrose in water was effective only for leukocyte motility, and ferric chlorophyll demonstrated a slight effect for the both functions and so did glucuronic acid although transient for the phaocytsois. en-copyright= kn-copyright= en-aut-name=NishidaTakeshi en-aut-sei=Nishida en-aut-mei=Takeshi kn-aut-name=西田彪 kn-aut-sei=西田 kn-aut-mei=彪 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=581 end-page=586 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spectrochemical Studies on Bile Pigment. Part 1. Spectrochemical Studies on the Pigments in Urine, Especially on the Bile Pigment kn-title=胆汁色素の分光化学的研究 第1編 尿色素特にその胆汁色素の分光化学的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1. The absorption spectra of urobilin, bilirubin, uroerythrin, urochrom A and urochrom B were determined after separating them from urine. 2. In the absorption spectra using some solvents, there were other absorption spectra which were specific to the solvents and unspecific to the solutes. The mechanism of these absorption spectra was clarified. 3. Besides urochrom, uroerythrin had the most contributing factor to the color of urine, on the other hand urobilin and bilirubin were displaying very little rolls. en-copyright= kn-copyright= en-aut-name=HizutaTuguo en-aut-sei=Hizuta en-aut-mei=Tuguo kn-aut-name=日伝二雄 kn-aut-sei=日伝 kn-aut-mei=二雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=587 end-page=591 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spectrochemical Studies on Bile Pigment Part 2. Spectrochemical Features of Biliverdin, Bilirubin and of their Decomposition Pigments kn-title=胆汁色素の分光化学的研究 第2編 Biliverdin, Bilirubin及びその分解によつて生ずる各種色素の分光化学的諸性状について en-subtitle= kn-subtitle= en-abstract= kn-abstract=After clarifying the spectrochemical features of biliverdin and bilirubin, absorption spectral analyses of their oxidative decompositions, absorption spectral analyses of their oxidative decompositions, following chromatographic fractions, were performed, and the following results were obtained. 1. As biliverdin was unstable chemically, accessory products were easily formed by washing bilirubin with water. 2. Choletelin, propentdyopent urochron etc, were proved, following the oxidation of biliverdin, 3. A blue colored chemically unstable substance was present after the oxidation of bilirubin, at wihch time the formations of biliverdin, propentdyopent and urochrom were proved in the absorption spectra. en-copyright= kn-copyright= en-aut-name=HizutaTuguo en-aut-sei=Hizuta en-aut-mei=Tuguo kn-aut-name=日伝二雄 kn-aut-sei=日伝 kn-aut-mei=二雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=593 end-page=600 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Serological Reactions in Infectious Hepatitis Part 1. Studies on Auto-Liver-Antibody by Means of Colloidion Agglutination Reaction kn-title=肝炎の血清反応に関する研究 第1編 コロジウム凝集反応による肝自己抗体の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Studying the significance of serological diagnosis of auto-liver-antibody by means of collodion agglutination reaction, and also observing the production of the antibody following a few experimental liver impairments, the following results were obtained. 1. Positive titers of agglutination was determined as 128 times since the majority of the collodion agglutination reactions in the healthy individuals as well as in the cases of extrahepatic diseases, demonstrated below 128 times. 2. The positive titers of agglutination were noted in 73.9% on investigating the auto-liver-antibody of infectious hepatitis by means of the collodion agglutination reaction. 3. Observing the alteration of the auto-liver-antibody of infectious hepatitis by means of the collodion agglutination reaction and complement fixation reaction, it was noted that the collodion agglutination was more sensitive and that there were relatively high positive titers of the antibody in the acute stages (the second and third week) as well as in the chronic stages. 4. In the mutual relations between the quantities of the auto-liver-antibody detected by the agglutination reaction, the various clinical pictures and the laboratory data of infectious hepatitis, the reactive positive titer of agglutination have increased in proportion to serum colloid liver function tests, serum bilirubin (over 1 to 2 mg. %), positive urine urobilinogen reaction, and to hepato-splenomegalia. No evident correlation was noted between the reactive positive titers of agglutinations and the hemograms of infectious hepatitis, but in the group of the positive reaction fairy numbers of the cases with lymphocytosis and monocytosis were seen, compared with the group of negative ones. 5. Detecting the auto-liver-antibody by means of the collodion agglutination reaction have reflected the clinical pictures fairly well and would be a effective means for clarify the pathophysiology of hepatic diseases. 6. For the purpose of the investigation regarding the production of the auto-liver-antibody in case of aseptic liver impairment, experiments were performed such as aseptic squeezing, cauterization and ligation of the common bile duct. In these experiments, a production of the auto-liver-antibody was confirmed, in relatively early stages, by means of the collodion agglutination reaction. en-copyright= kn-copyright= en-aut-name=HinoMasuo en-aut-sei=Hino en-aut-mei=Masuo kn-aut-name=日野益雄 kn-aut-sei=日野 kn-aut-mei=益雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=601 end-page=607 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Serological Reactions in Infectious Hepatitis Part 2. Studies on Hetero-Erythrocyte Agglutination Reaction in Infectious Hepatitis kn-title=肝炎の血清反応に関する研究 第2編 流行性肝炎における異種赤血球凝集反応に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing erythrocyte agglutination reaction mainly in infectious hepatitis and with considerations of the correlation between sheep and rabbit erythrocyte agglutination and of absorption test, the following results were obtained. 1. In infectious hepatitis, the agglutination titer for rabbit erythrocyte agglutination reaction exhibited fairly high value and appeared to be almost paralled with that for sheep erythrocyte agglutination reaction. In this experiment, however, it seemed to be difficult to argue on the presence of Forssman-antibody. 2. The erythrocyte agglutination reaction with trypsin modified sheep erythrocytes showed fairly high titers in infectious hepatitis and even in other diseases compared with the agglutination titers for sheep erythrocyte agglutination reaction (Paul-Bunnell reaction). But, the alteration of these titers were approximately in proportion to those of Paul-Bunnell reaction. 3. In the absorption test of the sheep erythrocyte agglutination reaction in infectious hepatitis, the absorptions for boiled guinea pig kidney, guinea pig liver, bovine and sheep erythrocyte were quite variable and irregular. But, in a fairly number of cases of infectious hepatitis, moderately increased absorptions for guinea pig kidney and bovine erythrocytes were observed. In view of the alteration of the absorptions, during the periods of infections, the difference of the nature of the antibodies in infectious hepatitis and normal sera was predicted. en-copyright= kn-copyright= en-aut-name=HinoMasuo en-aut-sei=Hino en-aut-mei=Masuo kn-aut-name=日野益雄 kn-aut-sei=日野 kn-aut-mei=益雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=331 end-page=339 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Weakening of Resistance of Isoniazid-Resistant Tubercle Bacilli, Catalase-Activity and Virulence Part U Study on Weakening of INH Resistance under the Influence of Sulfa Drugs kn-title=INH耐性結核菌の耐性低下ならびにcatalase活性と毒力に関する研究 第2編 サルフア剤影響下のINH耐性低下に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to make clear the mechanism of how the INH resistance weakens under the influence of sulfa drugs, the author conducted experiments by using the method of mixed population and also tested the susceptibility of INH resistant bacilli and INH receptive bacilli to sulfa drugs and their gaining of resistance against sulfa drgus. By such experiments, the author obtained the following results. 1. In the case of studying the clone of a perfect INH resistant strain for generations cultured in a SI-added culture medium, the author observed no weakening of the resistance. 2. Rapid weakening of INH resistance was found in the bacilli cultured in a SI-added medium for generations by use of the method of mixed population. Assuming that this phenomenon of weakening might be attributable to the difference between the susceptibility of INH resistant bacilli to SI and that of INH receptive bacilli to SI, the author further examined but was unable to find any bacterioseptic action in either bacilli by adding 500γ of SI. As regards bacteriostatic action, no difference was observed in the case of small inoculation of bacilli. In the case of massive inoculation of bacilli difference of some measure appeared. The results of the experiments seem to indicate that, although there is no difference in the susceptibility itself between INH resistant bacilli and INH receptive bacilli to SI, SI had delicate effects in delaying the growth of INH resistant bacilli. 3. The author studied the bacteriostatic action of long acting sulfa drugs such SD, SIM, SP and SMP and found that the action of SD and SIM was most violent, about twice as much as that of SI. The bacteriostatic action of SP was a little milder than that of SD and SIM and that of SMP most mild. As regards the bacteriostatic action of long acting sulfa drugs such as the ones quoted in the above on INH resistant bacilli and INH receptive bacilli, no significant difference could be found. 4. No difference was observed in the process of gaining resistance against SI between INH resistant bacilli and receptive bacilli. The resistance of neither bacilli increased beyond 125γ. en-copyright= kn-copyright= en-aut-name=NakataniAkira en-aut-sei=Nakatani en-aut-mei=Akira kn-aut-name=中谷照 kn-aut-sei=中谷 kn-aut-mei=照 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=645 end-page=651 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Mechanism of Bile Pigment Formation in vivo Part 1. On the Mechanism of Bile Pigment Formation in the Liver of Rabbit kn-title=生体内胆汁色素生成過程に関する研究 第1編 家兎肝臓内胆汁色素生成機序について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Irrigation experiments were performed on the liver of rabbit determining bilirubin and biliverdin in the bile and irrigating solution, and the following results were obtained. 1. Upon irrigation with hemoglobin added blood, bilirubin was not detected from the irrigating solution, however, the excretion of biliverdin and indirect bilirubin resulted from decomposition of hemoglobin, was observed. It is hard to determin whether these biliverdin and indirect bilirubin really stemmed from hemoglobin or from hemolysis during the irrigation. The reticuloendothelial system in the liver and liver cells played important roles in the formation of biliverdin and indirect bilirubin from hemoglobin. 2. Upon irrigation with verdohemochrome added blood, the verdohemochrome was easily decomposed into biliverdin and bilirubin. They were excreted into the bile, and reticuloendothelial system and liver cells would be involved in these depositions. 3. Upon irrigation with biliverdin added blood, over a half of the biliverdin was excreted into the bile. The excreting biliverdin was found to be two forms, the one was biliverdin without any change and the other was bilirubin deoxidized from biliverdin. In the cases with impairment of reticuloendothelial system and/or of liver cells, the excretions of these pigments were rather accelated. The process of the deoxidization of biliverdin into bilirubin took place not only in reticuloendothelial system but even after the excretion from the liver into the bile ducts. 4. In the mechanism of bile pigment formation, not only the reticuloendothelial system played an important role but the liver cells did. en-copyright= kn-copyright= en-aut-name=AkagiKaoru en-aut-sei=Akagi en-aut-mei=Kaoru kn-aut-name=赤木香 kn-aut-sei=赤木 kn-aut-mei=香 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=341 end-page=353 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Weakening of Resistance of Isoniazid-Resistant Tubercle Bacilli, Catalase-Activity and Virulence Part V Study on Catalase Activity and Virulence of INH Resistant Bacilli kn-title=INH耐性結核菌の耐性低下ならびにcatalase活性と毒力に関する研究 第3編 INH耐性結核菌のcatalase活性と毒力に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to see the relation between the catalase activity and virulence of INH resistant bacilli, the author studied the clone of INH resistant bacilli in vitro, looked into its catalase activity and the change of activity as generation descends and tested the virulence by inoculating guinea pigs with each generation of the bacilli. The results found were as follows: 1. The INH resistance bacilli obtained in one step was found to have a resistance potential of 0.05γ or more and to have lost its catalase activity. At this stage the selectivity of INH resistant bacilli which has a resistance of 0.05γ-10γ and the population composition of each group were similar. Therefore it is believed that the metabolic system of INH resistant bacilli made available by means of selection by use of drugs is different from that of receptive bacilli, and that the loss of catalase activity is attributable to this difference. 2. It was found that the negative catalase activity of INH 10γ resistant strains using the clone can be changed to positive by changing the conditions of the culture medium. Other multiple resistant strains which have the INH resistance are all C (-) and could not be changed to C (+) by changing the conditions of the culture medium. Therefore it is presumed that there is greater difference in the metabolic system between a single resistance strain which resists only INH and multiple resistance strain which resists not only INH. 3. A H(2)O(2) resistance test was given in respect of C (-) INH resistant bacilli and INH resistant bacilli the catalase activity of which had been changed from negative to positive and found that the resistance of both bacilli weakens compared to that of receptive bacilli and also that even the catalase activity of INH resistant bacilli changed from negative to positive is far weaker than that of receptive bacilli. 4. The author tested the virulence of C (-) INH resistant bacilli and INH resistant bacilli the catalase of which changed from negative to positive on guinea pigs, and found that the virulence of both had weakened. The author also tested virulence of each generation of cultured bacilli and found that it had lost its virulence. Juding from the results of the tests, it appears that the weakening of the virulence of INH resistant bacilli is an inherent property of the bacilli itself. However, the results of the H(2)O(2) resistance tests seem to indicate that the relation between the virulence and catalase cannot be completely denied. Further the author inoculated guinea pigs with C (-) INH resistant bacilli and some with C (+) INH resistant bacilli and separated them into two groups, one group killed at 3rd week and the other group killed at 8th week after the inoculation and found many cases of local disorder in the group killed at 3rd week irrespective of the kind of catalase, which led to believe that the disorder of guinea pigs attributable to INH resistant bacilli is reversible. en-copyright= kn-copyright= en-aut-name=NakataniAkira en-aut-sei=Nakatani en-aut-mei=Akira kn-aut-name=中谷照 kn-aut-sei=中谷 kn-aut-mei=照 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=653 end-page=662 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Mechanism of Bile Pigment Formation in Vivo Part 2. Studies on the Bile Pigment in the Bile following the Administration of the Decompositions of Hemeglobin kn-title=生体内胆汁色素生成過程に関する研究 第2編 血色素分解産物負荷による胆汁中胆汁色素の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Studying the formation process of the bile pigment in vivo with reference to the vicisitude of the bile pigment in the bile following the administration of the docompositions of hemoglobin into the portal vein of the rabbit with artificial biliary fistula. And the following results were obtained. 1. Following the administration of saline into the portal vein, production of the bile pigment in the liver was transiently depressed and then increased because of choleretic action of saline. 2. Following the administration of verdohemochrome solution, which was decomposed into biliverdin and, in part, was deoxidized to bilirubin. verdohemochrome was excreted in the healthy cases. The decomposition process was prolonged or less in the cases with blocked reticuloendothelial systems, and little decomposition was observed in the cases with liver impairments. 3. Following the administration of biliverdin solution to the healthy cases, the majority of biliverdin was excreted unchanged but part of it was deoxidized to bilirubin. There was no such evidence in the cases with blocked reticuloendothelial system and was very slight degree in the cases with liver impairment. In consequence, the deoxidation of biliverdin was presumably due to reticuloendothelial system. However, in the cases with blocked reticuloendothelial system or liver impairment, it was supposed that biliverdin was excreted from the liver and easily deoxidized into bilirubin. en-copyright= kn-copyright= en-aut-name=AkagiKaoru en-aut-sei=Akagi en-aut-mei=Kaoru kn-aut-name=赤木香 kn-aut-sei=赤木 kn-aut-mei=香 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=663 end-page=670 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Particular Environmental Influences to a Feu Components of Blood in Mountainous Farm Village Part 1. Serum Protein Fractions in Various Conditions kn-title=農山村の特種環境が血液中二,三の成分に及ぼす影響に関する研究 第1編 各種条件下における血清蛋白像について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Studying the influences of particular envireronment in the mountainous farm village of Hokuriku-district to serum protein fractions, and the following results were obtained. 1. In the farming seasons, in contrast to the leisure seasons for farmers, a slight decrease in total serum protein and a relative increase in α1, α2 and β-globulin were noted. 2. In the cases of malnutrition, seen during the farming seasons, a decrease in total serum protein, especially in albumin fraction, and a relative increase in α1, α2 and β-globulin were noted. 3. The changes of the serum proteins during the farming seasons were rather due to poor nutrition and fatigue than seasonable climates. 4. In the cases of pulmonary tuberculosis, increased total protein, decreased albumin and increased α1, α2 and γ-globulin were noted in the severe cases, on the other hand, in the mild or convalescent cases, a slight increase of γ-globulin was observed. 5. In the group of essential hypertension, a decrease in albumin and an increase in α1 and β-globulin were noted only in the severe cases with complications. 6. In the cases of angina pectoris with coronary insufficiency, a slight decrease in albumin and a slight increase in γ-globulin were seen, however, these changes were disappeared in the convalescent stages. In the cases of myocardial infarction, a slight decrease in total serum protein, a marked decrease in albumin and a slight increase in β and especially γ-globulin were observed. 7. In the cases of valvular heart diseases, a decrease in albumin and an increase in γ-globulin in the compensated phase, and in the decompensated phase these tendencies have become evident. 8. In the cases of stomach cancer especially of its terminal stage, a marked decrease in total serum protein, especially in albumin, and a moderate increase in γ, and a relative increase in α1, α2 and β globulin were noted. 9. In the cases of peptic ulcer, gastric and duodenal, a decrease in albumin and an increase in α1, and α2 globulin were observed. 10. In the pregnant females, no changes in serum protein fractions by 5 th month but thereafter a slight increase in α1, α2 and β-globuin and an increase in albumin were noted. These changes were evident especially in the cases of hyperemesis. en-copyright= kn-copyright= en-aut-name=ShinoharaToshio en-aut-sei=Shinohara en-aut-mei=Toshio kn-aut-name=篠原敏夫 kn-aut-sei=篠原 kn-aut-mei=敏夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=671 end-page=676 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Particular Environmental Influences to a Few Components of Blood in Mountainous Farm Village Part 2. Alteration of Serum Electrolytes, Especially of Calcium, in Various Conditions kn-title=農山村の特種環境が血液中二,三の成分に及ぼす影響に関する研究 第2編 各種条件下における血液無機物質特にカルシウム量の変動について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Studying the influences of particular environment in the mountainous farm village of Okunoto-district to serum electrolytes, especially to calcium, and the following results were obtained. 1. Serum calcium in the healthy farmers including both sexes demonstrated gradual alteration throughout the year with the minimum peak at May and June. 2. Serum electrolytes of the healthy male and female farmers were determined in both farming and leisure seasons for farmers. In the farming seasons, serum calcium was evidently decreased in both sexes compared with the leisure seasons for farmers, and, contrariwise, potassium was increased, and sodium was almost unchanged or slightly increased during the farming seasons. 3. It was supposed that such decrease in serum calcium during the farming seasons was not due to the influence of ultraviolet ray but to poor calcium intake by their eating habits and to fatigue as a result of the particular condition, the farming seasons. 4. In the control group of the healthy individuals other than farmers, serum calcium demonstrated almost no change throughout the year except for a very slight decrease during the periods of April, May and June. 5. In the school children, a decrease in serum calcium was noted during the winter time when ultraviolet rays were diminished. This indicated the fact that many babies suffering from rickets in this district. Such tendencies were also seen in the pregnant females. 6. A decrease in serum calcium due to diminution of ultraviolet rays were observed not only in the babies but in the school children and pregnant females except for the adults in good health. 7. A marked restoration of serum calcium level was noted 2 months after the administration of vitamin D and ultraviolet rays as a treatment of rickets. en-copyright= kn-copyright= en-aut-name=ShinoharaToshio en-aut-sei=Shinohara en-aut-mei=Toshio kn-aut-name=篠原敏夫 kn-aut-sei=篠原 kn-aut-mei=敏夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=677 end-page=694 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Nucleic Acid Metabolism in Pulmonary Tuberculosis Part 1. Uric acid Metabolism and the Effects of Vitamin B(12) and Folic Acid kn-title=肺結核症の核酸代謝に関する研究 第1編 肺結核症の尿酸代謝並びにこれに及ぼすビタミンB(12)及び葉酸の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Observing the amount of uric acid excretion into the urine in the healthy and various stages of pulmonary tuberculosis cases and studying the effects of vitamin B(12) and folic acid, and the following results were obtained. 1. An increase in the amount of uric acid excretion into the urine was noted in the cases of moderately and far advanced pulmonary tuberculosis. 2. In the healthy and postoperative cases of pulmonary tuberculosis cases, an increase, both in the concentration and the amount, of uric acid excretion into the urine was noted one hour after the administration of vitamin B(12). A slight decrease or unchanged in the amount of uric acid excretion into the urine was observed, one hour after the administration of folic acid, and an increase of it was seen in the urine after 4 hours. 3. The effects of vitamin B(12) and folic acid were less evident in the far advanced cases of pulmonary tuberculosis and rather marked in the minimal cases. 4. The same effects were observed in the cases who had the breakfast only of rice and soybean soup at the same time with the administration of vitamin B(12) or folic acid. Increased uric acid excretion into the urine was observed in the cases who had breakfast alone. 5. The effects of these vitamines were quite the same in the cases who had breakfast and vitamin B(12) or folic acid at the same time and also in the cases who had PAS-calcium later on. 6. It was supposed that vitamin B(12) and folic acid did not have an effect upon dietary purine bodies metabolism, but promote general metabolism and thus effect upon nucleic acid metabolism. Vitamin B(12) and folic acid have presumably regulated the uric acid metabolism in the cases of far advanced pulmonary tuberculosis. en-copyright= kn-copyright= en-aut-name=OhsumiMichiko en-aut-sei=Ohsumi en-aut-mei=Michiko kn-aut-name=大隅美智子 kn-aut-sei=大隅 kn-aut-mei=美智子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=695 end-page=711 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Nucleic Acid Metabolism in Pulmonary Tuberculosis Part 2. Alteration of Urine Ketoenolsubstances and the Effects of Vitamin B(12) and Folic Acid kn-title=肺結核症の核酸代謝に関する研究 第2編 肺結核症の尿ケトエノール物質の消長並びにこれに及ぼすビタミンB(12)及び葉酸の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Studying urine ketoenolsubstances (KES) and the effects of vitamin B(12) and folic acid in the healthy and pulmonary tuberculosis cases, and the following results were obtained. 1. An increase in the urine KES was noted in the cases of moderately and far advanced pulmonary tuberculosis. 2. In the healthy and postoperative cases, the urine KES were increased from two hours after the administration of vitamin B(12), and from one hour after the administration of folic acid respectively. 3. These effects of vitamin B12 and folic acid were decreased in such order as minimal, moderately advanced and far advanced pulmonary tuberculosis. 4. Following the administration of folic acid, an increased precipitation was noted on the determination of the urine KES. This precipitation would be a source of error and might be a excretion of folic acid itself. 5. The effects of these vitamines were quite the same in the cases who had the breakfast with rice and soybean soup at the same time with the administration of vitamin B(12) or folic acid. 6. The effects of these vitamines were quite the same in the cases who had breakfast and vitamin B(12) or folic acid at the same time and also in the cases who had PAS-calcium later on. However, attention should be paid for the determination of the urine KES because of the precipitation due to PAS-calcium. 7. It was supposed that vitamin B(12) and folic acid did not have an effect upon dietary purine body metabolism, but promote general metabolisms and thus effect upon nucleic acid metabolism. Vitamin B12 and folic acid did not regulate the metabolism of KES which were excreted in the far advanced pulmonary tuberculosis cases. en-copyright= kn-copyright= en-aut-name=OhsumiMichiko en-aut-sei=Ohsumi en-aut-mei=Michiko kn-aut-name=大隅美智子 kn-aut-sei=大隅 kn-aut-mei=美智子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=713 end-page=727 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Influences of Spleen on the Hematopoietic Function of Bone Marrow Part 1. Influences of Splenectomy, Homoioplastic Transplantation of Spleen, and of Spleen Extract on the Erythropoietic Function of the Rabbit Bone Marrow kn-title=脾臓の骨髄造血機能に及ぼす影響に関する実験的研究 第1編 剔脾,脾他家移植及び脾エキスが家兎骨髄造赤血球機能に及ぼす影響に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the purpose to study the influences of the spleen on the erythropoietic function of bone marrow the cell suspension culture of the rabbit bone marrow was conducted, and the following results were obtained. 1. In the bone-marrow tissue culture of splenectomized rabbits conducted from time to time the rate of the increase in the number of erythrocytes is temporarily accelerated having its peak around 4 to 7 days after the operation as compared with the control, while on the contrary, the increase in hemoglobin declines slightly. About three weeks after the operation both values of erythrocytes and hemoglobin return approximately to those in the control group, normal ones without splenectomy. 2. In the bone-marrow tissue culture of the rabbits transplanted with hemoioplastic spleenand conducted from time to time, the rate of the increase in the number of erythrocytes temporarily declines having the minimum around the fifth day after the operation and the rate of the increase in hemo-globin falls slightly around the fifth day but by around the thenth day it shows a slight acceleration, as compared with those of the control, rabbits transplanted with normal kidney. However, after about 30 days both of these values return approximately to those of the control. 3. In the observations of the bone-marrow tissue culture of normal rabbits with addition of Ringer's solutions of normal rabbit spleen extract at various concentrations, the extract at a higher concentration brings about the fall in the increasing rate of erythrocytes and hemoglobin, while on the contrary it brings about a slight acceleration in the increasing rate of both at a lower concentration. 4. From these results it is assumed that the spleen of the normal rabbit with the aid of some body-fluid agent adjusts the erythropoietic function of the bone marrow either suppressingly or acceleratingly, but from the physiological aspect the suppressing action seems to be superior: namely, an abnormal formation of the erythrocyte series is suppressed, while on the other hand the hemoglobin synthesis seems to be accelerated, thus suppressing the incomplete maturation of erythrocytes. en-copyright= kn-copyright= en-aut-name=KitajimaKoichi en-aut-sei=Kitajima en-aut-mei=Koichi kn-aut-name=喜多島康一 kn-aut-sei=喜多島 kn-aut-mei=康一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医学研究科 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=355 end-page=366 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=T. Effects of Drugs on the Cerebral Blood Flow of the perfused Cat Brain kn-title=T 灌流ネコ脳循環に及ぼす諸種薬物の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The influences of various drugs on the Cerebral Blood Flow (CBF) in the cats were investigated by the brain perfusion methode. The results were as follows. 1. Adrenaline constricted the brain vessels and decreased the C B F. 2. The CBF was decreased by the administration of Noradrenaline. 3. administration of large doses (1 mg) of Adrenaline and Noradrenaline was found to have an action on cerebral vasomotoric center, but this action was not found in small doses of these drugs. 4. Electrocorticogram was activated by the administration of large doses (over 0.1 mg) of Adrenaline and Noradrenaline, and the application of small doses (0.01 mg) of these drugs also had a tendency to activation of Electrocorticogram. 5. Papaverine exerted an augmenting effect on the CBF and dilated the brain vessels. 6. It was observed that Nicotinic Acid showed no change in CBF at small doses, however, with large doses of the drug, a slight increase of CBF occured. And Nicotinic Acid had no action on cerebral vasomotoric center. 7. The CBF was slightly increased by the application of small doses of Imidazoline, but at higher doses of the drug, the rate of increase in CBF showed diminution or no change in CBF was caused. 8. Imidazoline had no action on cerebral vasomotoric center. 9. Phenobarbital dilated the brain vessels and increased the CBF. 10. No significant changes in CBF were ovserved by the administration of Atropine. en-copyright= kn-copyright= en-aut-name=IchiyamaTakuji en-aut-sei=Ichiyama en-aut-mei=Takuji kn-aut-name=市山卓爾 kn-aut-sei=市山 kn-aut-mei=卓爾 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=729 end-page=743 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Influences of Spleen on the Hematopoietic Function of Bone Marrow Part 2. Influences of Spelenectomy, Homoioplastic Transplantation of Spleen, and of Spleen Extract on the Leucopoietic Function of the Rabbit Bone Marrow kn-title=脾臓の骨髄造血機能に及ぼす影響に関する実験的研究 第2編 剔脾脾他家移植及び脾エキスが家兎骨髄白血球系造血に及ぼす影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to observe the influences of spleen on the leucopoietic function of bone marrow the author performed the bone-marrow tissue culture (by cover-slip method) of rabbits, and obtained the following results. 1. In the observations on the bone-marrow tissue culture of the splenectomized rabbits conducted from time to time, the relative growth rate, the cell density index and the wandering velocity of pseudoeosinophils all show a transient acceleration with their peak around 4 to 7 days after the operation, while on the contrary the carbon particle phagocytic ability of pseudoeosinophils shows a transient fall. However, all these values return to respective levels of the control, normal rabbits without splenectomy, about 3 weeks after the operstion. 2. In the bone-marrow tissue culture of the rabbits transplanted with homoioplastic spleen conducted from time to time, the relative growth rate, the cell density index and the wandering velocity of pseudoeosinophils all show a transient fall around 5 to 10 days after the operation, but no marked change can be observed in the carbon particle phagocytic ability of pseudoeosinophils. However, all these values resurn approximately to those of the control, rabbits transplanted with normal kidney, about 30 days after the operation. 3. In the bone-marrow tissue culture of normal rabbits with addition of Ringer's solution of normal rabbit spleen extract, the extract at a higer concentration has a suppressing effect on the relative growth rate, the wandering velocity and the carbon particle phagocytic ability of pseudoeosinophils, while the extract at a lower concentration mostly gives a slightly accelerating effect. 4. From these results it seems that the spleen of normal rabbits with aid of some fluid agent adjusts the production of the leucocyte series of the bone marrow either suppressingly or acceleratingly. However, from the physiological aspect the suppressing action seems to be slightly superior and hence the over-production of the granulocyte series of the bone marrow as well as the incomplete maturation of granulocytes seem to be controled. en-copyright= kn-copyright= en-aut-name=KitajimaKoichi en-aut-sei=Kitajima en-aut-mei=Koichi kn-aut-name=喜多島康一 kn-aut-sei=喜多島 kn-aut-mei=康一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医学研究科 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=745 end-page=755 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Influences of Spleen on the Hematopoietic Function of Bone Marrow Part 3. Influences of Homoioplastic Transplatation of Spleen and Spleen extract on the Production of Platelet in the Guinea-pig Bone Marrow kn-title=脾臓の骨髄造血機能に及ぼず影響に関する実験的研究 第3編 脾他家移植及び脾エキスが海?骨髄栓球系造血に及ぼす影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the purpose of observing the influences of the spleen on the production of the platelet in bone marrow the author performed the bone-marrow tissue culture (cover-slip method) of guinea pigs and observed the function of megakaryocytes, and obtained the follo wing results. 1. In the bone marrow tissue culture of the guinea pigs transplanted with homoioplastic spleen conducted from time to time to the megakaryocyte function, when compared with that of the control group transplanted with normal spleen, shows a marked decline transiently about 3 to 5 days after the operation, but by 20th to 30th day it shows hardly any significant difference from that of the control. 2. In the bone-marrow tissue culture of normal guinea pigs added with Ringer's solution of spleen extract of normal guinea pigs, the extract at a higher concentration brings about a fall in the megakaryocyte function whereas on the contrary at a higher concentration it accelerates the function. 3. From these results it seems that the spleen of normal guinea pigs with the aid of some fluid agent acts on the thrombopoiesis of the bone marrow interchangeably either suppressingly or acceleratingly, but from the physiological aspect the suppressing action seems to be slightly stronger. en-copyright= kn-copyright= en-aut-name=KitajimaKoichi en-aut-sei=Kitajima en-aut-mei=Koichi kn-aut-name=喜多島康一 kn-aut-sei=喜多島 kn-aut-mei=康一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医学研究科 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=757 end-page=761 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Relation Between Tumor and Hormone Report 5. On the Effect of Sex Hormones on the Growth and Immunity of Tumor kn-title=腫瘍とホルモンに関する実験的研究 第5報 腫瘍免疫並びに増殖に及ぼす性ホルモンの影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Formerly, concerning the relation between hormone and heterotransplantation, the author reported that, while teststerone inhibited heterotransplantation, estrogen and testectomy acceralate it. In this experiment, mice of R(3) strain were used. All mice were transplanted of mammary carcinoma from the R(3) strain of female mouse. The conclusions of this experiment are as follows; 1) Testaterone inhibited the homotransplantation and growth of tumor. 2) Estrogen and testectomy acceraiate the homotransplantation and growth of tumor. en-copyright= kn-copyright= en-aut-name=KiyamaTakashi en-aut-sei=Kiyama en-aut-mei=Takashi kn-aut-name=木山敞 kn-aut-sei=木山 kn-aut-mei=敞 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=763 end-page=779 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Disturbance in Blood Clotting Following Massive Transfusion of Preserved Blood Part I. Experimental Investigation on the Mechanism of Disturbed Blood Clotting Following Massive Transfusion of Preserved Blood kn-title=保存血大量輸血に伴う血液凝固障害に関する研究 第1編 血液凝固障害発現の成因に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Influences of operative stress, shock, anoxia and/or liver damage upon the disturbances in blood clotting following massive transfusion of preserved blood were investigated experimentally. None of coagulation factors were so disturbed to invite a hemorrhagic tendency only by one of them. Qualitative and quantitative decrease in platelets and decrease in AHG level were thought to be caused by massive preserved blood transfusion itself. Decreases in prothrombin and labile factor following preserved blood transfusion were much intensive in case of accompanying with operative stress, shock, anoxia or liver damage. It was surmized that the occurrence of fibrinolysis had an imptortant part to cause the decrease in clotting factors. en-copyright= kn-copyright= en-aut-name=ShimizuHiroshi en-aut-sei=Shimizu en-aut-mei=Hiroshi kn-aut-name=志水浩 kn-aut-sei=志水 kn-aut-mei=浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=367 end-page=388 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=U. Effects of Chlorpromazine on the Function and metabolism of the Perfused Cat Brain kn-title=U Chlorpromazineの灌流ネコ脳髄に対する作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The cat brain was perfused through the isolated cerebral circulation by the modified Geiger & Magnes' methode, and the effects of Chlorpromazine (CP) on cerebral blood flow (CBF), blood pressure (BP), carbohydrate metabolism and electroencephalogram (EEC) were investigated by the use of the brain perfusion methode. The results were as follows. 1) The CBF was increased by the administration of small doses of CP while no significant changes in CBF were showed with large doses of the drug, and it is suggested that this finding is explainable on the basis of inhibition of the brain metabolism caused by the dosage. 2) BP kept intact or dropped case by case with CP, and it is considered that this difference may be due to individual characteristics of the cats, doses to be applied, degrees of operation etc.. When BP dropped in the case of perfusion, it means a central vasomotoric action. BP dropped to a level on the dosage best suited to individual, morever, its central vasodilatatoric action was more persistent and not to be influenced by the subsequent administration of CP, while the direct effect on dilating the cerebral blood vessels was transient and appeared similarly by the subsequent application of CP. 4) With a small dosage of CP, a tendency toward increase of the oxygen and glucose consumption, and most remarkable increase of the lactic acid liberation were observed. On the other hand, oxygen and glucose consumption, and lactic acid liberation were all diminished by the application of large doses of CP, and particularly, both the oxygen consumption and the lactic acid liberation was markedly diminished. And at the same time, I explained a little opinion about those alterations in metabolism. 5) The changes in EEGs of neocortex, paleocortex and archicortex were observed by the administration of CP. Namely, EEG of neocortex showed slowing of frequency and increase in amplitude with CP, and in hippocampus the regularity of hippocampal regular slow waves was lost and there appeared fast waves, contrarily, amygdala showed no change after the administration of CP and low voltage fast waves from beginning to end. en-copyright= kn-copyright= en-aut-name=IchiyamaTakuji en-aut-sei=Ichiyama en-aut-mei=Takuji kn-aut-name=市山卓爾 kn-aut-sei=市山 kn-aut-mei=卓爾 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=781 end-page=796 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Disturbance in Blood Clotting Following Massive Transfusion of Preserved Blood Part U. Clinical and Experimental Studies on the Prophylaxis and Therapy of Impaired Blood Clotting Following Massive Transfusion of Preserved Blood kn-title=保存血大量輸血に伴う血液凝固障害に関する研究 第2編 血液凝固障害発生の予防とその治療について en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the impaired blood clotting due to massive blood transfusion prophylaxis is to be the best treatment, for measures after its occurreance are often very difficult. As prophylactic treatment, continuous drip infusion of a large amount of hydrocortisone, alternated transfusion of fresh and preserved blood, administration of tissue thromboplastin preparation and ACTH were effective. As thrapy for hemorrhagic tendency, massive infusion of hydrocortisone, administration of tissue thromboplastin preparation, transions of fressh blood or platelets were proved to be effective. For decreased clotting factors in case fibrinolysis. intravenous ε-aminocapronic acid and hydrocortisone were efficacious to depress the fibrinolysis. en-copyright= kn-copyright= en-aut-name=ShimizuHiroshi en-aut-sei=Shimizu en-aut-mei=Hiroshi kn-aut-name=志水浩 kn-aut-sei=志水 kn-aut-mei=浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=2 article-no= start-page=797 end-page=799 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Influences of γ-Amino-β-hydroxybutyric Acid (GABOB) On the Mouse Brain Water Content kn-title=脳含水量におよぼすγ-アミノ-β-ハイドロオキシ酪酸の影響に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The influences of GABOB on water content of CF-1 pure strain mouse cerebral cortex having artificaly increased water content in cerebral cortex and non treated one as the control were investigated, and it was clarfied that GABOB has no effect on the water content of the brain in both cases. en-copyright= kn-copyright= en-aut-name=HigashiTohru en-aut-sei=Higashi en-aut-mei=Tohru kn-aut-name=東徹 kn-aut-sei=東 kn-aut-mei=徹 aut-affil-num=1 ORCID= en-aut-name=MoriAkitane en-aut-sei=Mori en-aut-mei=Akitane kn-aut-name=森昭胤 kn-aut-sei=森 kn-aut-mei=昭胤 aut-affil-num=2 ORCID= en-aut-name=YoshikawaTamotsu en-aut-sei=Yoshikawa en-aut-mei=Tamotsu kn-aut-name=吉川全 kn-aut-sei=吉川 kn-aut-mei=全 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1(陣内)外科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第1(陣内)外科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第1(陣内)外科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1123 end-page=1142 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Vergleichungsstudien ?ber die verschiedenen Trockenmittel kn-title=各種除濕劑ノ比較研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Um praktisch die Wirkung der Entfeuchtung bei geschlossenem Raum zu studieren, stellten wir in das dicht geschlossene Laboratoriumzimmer einen mit Papier ?berzogenen Glaskasten (1cm) ein, mit dem man eine bestimmte Temperatur und Feuchtigkeit erzeugen kann. Die relative Feuchtigkeit im Versuchskasten wird durch Einf?hrung von Wasserdampf auf ?ber 90% gesteigert, dann wird eine bestimmte Menge von verschiedenen Trockenmitteln (Calcium chloratum purum f?r Analyse von Isizu, Calcium chloratum siccum f?r Trocknung, Calcium chloratum siccum neutrale von Merck, I. D. Trockenmittel, Adsole, Schwefels?ure, und Wolle) in den Kasten eingef?hrt. Die Wirkung der Trockenmittel wird zeitlich durch verschiedene Psychrometer (Augustsche, Assmannsche, Fuessche, Lambrechtsche Psychrometer) untersucht. Dabei werden die Katawerte mit einem Wett-katathermometer bestimmt. Da die relative Feuchtigkeit von der Ver?nderung der Temperatur abh?ngt, wurden alle Untersuchungen immer in einer bestimmten Temperatur ausgef?hrt. Diese Versuche wurden im Sommer (bei 30 C) und im Winter (bei 10 C) angestellt, weil die Wirkung der Trockenmittel durch die Temperatur mehr oder minder beeintr?chtigt wird. 1) Bei hoher Temperatur im Sommer, d. h. bei 30 C, zeigt sich Calcium chloratum in bezug auf Lufttrockung am st?rksten, dann folgen I. D. Trockenmittel, Adsole, Schwefels?ure und Wolle. 2) Bei niedriger Temperatur im Winter, d. h. bei 10 C, abfeuchtet Calcium chloratum am st?rksten, es folgend I. D. Trockenmittel und Adsole. Unter Calcium chloratum wirkt als Trockenmittel das Calcium chloratum purum f?r Analyse am st?rksten, diesem folgt Calcium chloratum siccum neutrale von Merck, Calcium chloratum siccum steht hinter diesen ziemlich weit zur?ck. 3) Es ist bemerkenswert, dass die Absorptionskraft f?r die Luftfeuchtigkeit haupts?chlich von der Fl?chengr?sse der Absorptionsmittel abh?ngig ist. Wenn man also gekl?mpftes Calcium chloratum siccum fein zerbricht, so steigt seine Absorptionskraft auf die des Calcium chloratum purum f?r Analyse. 4) In der gleichen Weise kann man durch verteilte Anwendung des Trockenmittels viel bessere Resultate erzielen als bei einmaligem Gebrauch desselben. 5) Die Trockenmittel zeigen ihre Absorptionskraft bei hoher Temperatur im Sommer deutlich st?rker als bei niedriger Temperatur im Winter. en-copyright= kn-copyright= en-aut-name=OhtaharaKazuyoshi en-aut-sei=Ohtahara en-aut-mei=Kazuyoshi kn-aut-name=大田原一祥 kn-aut-sei=大田原 kn-aut-mei=一祥 aut-affil-num=1 ORCID= en-aut-name=IshiharaTadayuki en-aut-sei=Ishihara en-aut-mei=Tadayuki kn-aut-name=石原忠之 kn-aut-sei=石原 kn-aut-mei=忠之 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學衛生學教室 affil-num=2 en-affil= kn-affil=岡山醫科大學衛生學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=801 end-page=810 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Epidemiological Observations on Infectious Hepatitis Prevailed in Okayama Prefecture kn-title=岡山県における流行性肝炎の流行に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=6246 infectious hepatitis cases treated at 25 hospitals located in Okayama Prefecture during the last six years, 1952 to 1957, were studied mainly from the epidemiological point of view, and the following results were obtained. 1) Infectious hepatitis has been prevailed all over the prefecture since the initial epidemic in 1951. As the mode of epidemic became protracted, chronic and abortive forms were prone to increase in number. The ratio of total patients to infectious hepatitis cases was 1.27 per cent. 2) Extensive infections among villagers were noted in 73 hamlets, and it was presumed that the epidemic has been prevailed over the whole prefecture taking a hamlet, village or a town as unit. Infections among family were noted in 62 families, however, fnrther detailed study in the epidemic areas might show the higher morbidity. It was not certain whether these infections were entirely family or simultaneous infections. 3) As to seasonal occurence, considerable number of cases had onset of the disease during the period of early summer to early fall. 4) As to age, it has ranged mostly from the second to third decade, rather many in children but not rare in the aged. As to sex, predominant in males in general, but considerable differences were seen among hospitals and times. No definite relationship was noted between the epidemc and sex. 5) Throughout the last six years there have been 38.7 per cent of chronic hepatitis cases. In 41.3 per cent of the whole patients presented jaundice in their clinical courses. The fact that the longer the period of the epidemic the more increase increase in anicteric cases was noted. 6) Two year's follow-up studies after the epidemic, showed 209 of relapsed cases in whom 36.4 per cent were icteric. 7) 110 cases has jaundice, which was thought to be infectious hepatitis, in the past. Some of them were presumably reinfections or superinfections but definite conclusion could not be made. 8) 20 cases of fulminant hepatitis, malignant type of infectious hepatitis, and 6 cases of protracted form were studied. 22 cases of them were fatal. Such severe hepatitis patients were seen mainly in males of the second and third decades. 9) 61 cases (0.98%) developed postnecrotic cirrhosis, and 10 cases of them were fatal. 10) Serum hepatitis was noted in 1.6 per cent of the whole patients seen in Medical Services at 18 hospitals in Okayama Prefecture during the last six years, 1952 to 1957. No definite correlation between the epidemic of infectious hepatitis and outbreak of serum hepatitis was noted. en-copyright= kn-copyright= en-aut-name=KosakaKiyowo en-aut-sei=Kosaka en-aut-mei=Kiyowo kn-aut-name=小坂淳夫 kn-aut-sei=小坂 kn-aut-mei=淳夫 aut-affil-num=1 ORCID= en-aut-name=NagashimaHideo en-aut-sei=Nagashima en-aut-mei=Hideo kn-aut-name=長島秀夫 kn-aut-sei=長島 kn-aut-mei=秀夫 aut-affil-num=2 ORCID= en-aut-name=ShimadaYoshihiro en-aut-sei=Shimada en-aut-mei=Yoshihiro kn-aut-name=島田宜浩 kn-aut-sei=島田 kn-aut-mei=宜浩 aut-affil-num=3 ORCID= en-aut-name=YamabukiTakahiro en-aut-sei=Yamabuki en-aut-mei=Takahiro kn-aut-name=山吹隆寛 kn-aut-sei=山吹 kn-aut-mei=隆寛 aut-affil-num=4 ORCID= en-aut-name=KawaguchiMasamitsu en-aut-sei=Kawaguchi en-aut-mei=Masamitsu kn-aut-name=川口正光 kn-aut-sei=川口 kn-aut-mei=正光 aut-affil-num=5 ORCID= en-aut-name=YamamotoShigeru en-aut-sei=Yamamoto en-aut-mei=Shigeru kn-aut-name=山本繁 kn-aut-sei=山本 kn-aut-mei=繁 aut-affil-num=6 ORCID= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name=太田康幸 kn-aut-sei=太田 kn-aut-mei=康幸 aut-affil-num=7 ORCID= en-aut-name=UjikeMutsuo en-aut-sei=Ujike en-aut-mei=Mutsuo kn-aut-name=氏家睦夫 kn-aut-sei=氏家 kn-aut-mei=睦夫 aut-affil-num=8 ORCID= en-aut-name=KusakaYoshiro en-aut-sei=Kusaka en-aut-mei=Yoshiro kn-aut-name=草加芳郎 kn-aut-sei=草加 kn-aut-mei=芳郎 aut-affil-num=9 ORCID= en-aut-name=MitsudaToshihiro en-aut-sei=Mitsuda en-aut-mei=Toshihiro kn-aut-name=光田利弘 kn-aut-sei=光田 kn-aut-mei=利弘 aut-affil-num=10 ORCID= en-aut-name=KiharaTsuyoshi en-aut-sei=Kihara en-aut-mei=Tsuyoshi kn-aut-name=木原彊 kn-aut-sei=木原 kn-aut-mei=彊 aut-affil-num=11 ORCID= en-aut-name=KondoTadasuke en-aut-sei=Kondo en-aut-mei=Tadasuke kn-aut-name=近藤忠亮 kn-aut-sei=近藤 kn-aut-mei=忠亮 aut-affil-num=12 ORCID= en-aut-name=HaraokaSyoichi en-aut-sei=Haraoka en-aut-mei=Syoichi kn-aut-name=原岡昭一 kn-aut-sei=原岡 kn-aut-mei=昭一 aut-affil-num=13 ORCID= en-aut-name=AmiokaTadashi en-aut-sei=Amioka en-aut-mei=Tadashi kn-aut-name=網岡忠 kn-aut-sei=網岡 kn-aut-mei=忠 aut-affil-num=14 ORCID= en-aut-name=IshimitsuTetsusaburo en-aut-sei=Ishimitsu en-aut-mei=Tetsusaburo kn-aut-name=石光鉄三郎 kn-aut-sei=石光 kn-aut-mei=鉄三郎 aut-affil-num=15 ORCID= en-aut-name=KonoHiroya en-aut-sei=Kono en-aut-mei=Hiroya kn-aut-name=河野浩哉 kn-aut-sei=河野 kn-aut-mei=浩哉 aut-affil-num=16 ORCID= en-aut-name=MitsumotoToshiro en-aut-sei=Mitsumoto en-aut-mei=Toshiro kn-aut-name=光本敏郎 kn-aut-sei=光本 kn-aut-mei=敏郎 aut-affil-num=17 ORCID= en-aut-name=AisakaTadakazu en-aut-sei=Aisaka en-aut-mei=Tadakazu kn-aut-name=相坂忠一 kn-aut-sei=相坂 kn-aut-mei=忠一 aut-affil-num=18 ORCID= en-aut-name=KosakaChuihiro en-aut-sei=Kosaka en-aut-mei=Chuihiro kn-aut-name=小坂忠一郎 kn-aut-sei=小坂 kn-aut-mei=忠一郎 aut-affil-num=19 ORCID= en-aut-name=MoritaniYui en-aut-sei=Moritani en-aut-mei=Yui kn-aut-name=森谷有為 kn-aut-sei=森谷 kn-aut-mei=有為 aut-affil-num=20 ORCID= en-aut-name=TabuchiHiroshi en-aut-sei=Tabuchi en-aut-mei=Hiroshi kn-aut-name=田渊博司 kn-aut-sei=田渊 kn-aut-mei=博司 aut-affil-num=21 ORCID= en-aut-name=HashimotoKyoji en-aut-sei=Hashimoto en-aut-mei=Kyoji kn-aut-name=橋本恭治 kn-aut-sei=橋本 kn-aut-mei=恭治 aut-affil-num=22 ORCID= en-aut-name=KimuraKenichi en-aut-sei=Kimura en-aut-mei=Kenichi kn-aut-name=木村健一 kn-aut-sei=木村 kn-aut-mei=健一 aut-affil-num=23 ORCID= en-aut-name=KonoHiroshi en-aut-sei=Kono en-aut-mei=Hiroshi kn-aut-name=河野宏 kn-aut-sei=河野 kn-aut-mei=宏 aut-affil-num=24 ORCID= en-aut-name=TamaoHiroyasu en-aut-sei=Tamao en-aut-mei=Hiroyasu kn-aut-name=玉尾博康 kn-aut-sei=玉尾 kn-aut-mei=博康 aut-affil-num=25 ORCID= en-aut-name=HiguchiYosimitsu en-aut-sei=Higuchi en-aut-mei=Yosimitsu kn-aut-name=樋口祥光 kn-aut-sei=樋口 kn-aut-mei=祥光 aut-affil-num=26 ORCID= en-aut-name=YahataKatsumi en-aut-sei=Yahata en-aut-mei=Katsumi kn-aut-name=八幡勝美 kn-aut-sei=八幡 kn-aut-mei=勝美 aut-affil-num=27 ORCID= en-aut-name=ImaiHarujiro en-aut-sei=Imai en-aut-mei=Harujiro kn-aut-name=今井春路郎 kn-aut-sei=今井 kn-aut-mei=春路郎 aut-affil-num=28 ORCID= en-aut-name=KameyamaIchiro en-aut-sei=Kameyama en-aut-mei=Ichiro kn-aut-name=亀山一郎 kn-aut-sei=亀山 kn-aut-mei=一郎 aut-affil-num=29 ORCID= en-aut-name=ArijiSumiro en-aut-sei=Ariji en-aut-mei=Sumiro kn-aut-name=有地澄郎 kn-aut-sei=有地 kn-aut-mei=澄郎 aut-affil-num=30 ORCID= en-aut-name=FujimoriYasuhiko en-aut-sei=Fujimori en-aut-mei=Yasuhiko kn-aut-name=藤森恭彦 kn-aut-sei=藤森 kn-aut-mei=恭彦 aut-affil-num=31 ORCID= en-aut-name=NakagawaSyoso en-aut-sei=Nakagawa en-aut-mei=Syoso kn-aut-name=中川昌壮 kn-aut-sei=中川 kn-aut-mei=昌壮 aut-affil-num=32 ORCID= en-aut-name=HiranoYutaka en-aut-sei=Hirano en-aut-mei=Yutaka kn-aut-name=平野寛 kn-aut-sei=平野 kn-aut-mei=寛 aut-affil-num=33 ORCID= en-aut-name=KobayashiToshinari en-aut-sei=Kobayashi en-aut-mei=Toshinari kn-aut-name=小林敏成 kn-aut-sei=小林 kn-aut-mei=敏成 aut-affil-num=34 ORCID= en-aut-name=SeidoIchiro en-aut-sei=Seido en-aut-mei=Ichiro kn-aut-name=清藤一郎 kn-aut-sei=清藤 kn-aut-mei=一郎 aut-affil-num=35 ORCID= en-aut-name=TanabeIsao en-aut-sei=Tanabe en-aut-mei=Isao kn-aut-name=田辺功 kn-aut-sei=田辺 kn-aut-mei=功 aut-affil-num=36 ORCID= en-aut-name=TakedaKazuhisa en-aut-sei=Takeda en-aut-mei=Kazuhisa kn-aut-name=武田和久 kn-aut-sei=武田 kn-aut-mei=和久 aut-affil-num=37 ORCID= en-aut-name=HayashiShinichiro en-aut-sei=Hayashi en-aut-mei=Shinichiro kn-aut-name=林愼一郎 kn-aut-sei=林 kn-aut-mei=愼一郎 aut-affil-num=38 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=13 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=14 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=15 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=16 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=17 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=18 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=19 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=20 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=21 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=22 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=23 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=24 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=25 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=26 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=27 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=28 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=29 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=30 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=31 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=32 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=33 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=34 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=35 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=36 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=37 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=38 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=389 end-page=406 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Seminal Vesiculogram in Male Sterility kn-title=男子不妊症における精嚢腺レ線像の研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Seminal vesicles were atrophied or not developed according to the lowering of the androgenic activities of the testis an I found tuberculous infection in them frequently. And it is well-known such conditions result in the disturbance of the sperm nutrition and the sperm passage which lead to the male sterility respectively. From these points, I have been, for the past seven years, observing the rentogenologic forms of semlnal vesicles about male sterility of 106 cases, and found out their morphological variations. On the classifications of seminal vesiculograms, there have been many reports, but could not be found that of seminal vesiculograms about male sterility. Then, it is intended to classify the forms of seminal vesicles of my cases as follows. 1. great main tubes with large laminated diverticula 2. great main tubes with or without small diverticula 3. simple main tubes with large laminated diverticula 4. simple main tubes with or without small diverticula 5. main tubes, dilated abnormally, demarcated poorly or irregularly, and no shaped seminal vesicles by means of the difficulties in injection of contrast medias into the vas deferens (stricture, obstruction or absence of it) The writer utilized vasopuncture of scrotal region and through the vas deferens injected Urografin and Urokolin-M into seminal vesicles. As table (2-16) shows, in seminal vesicles type No. 1 of the classification commanded a plurality (49.5%), Type No. 2 is the second (28.3%) and in Ampulla ductus deferentis, type No. 1 is first in number (60.6%) and type No. 2 next (19.2%). Seminal vesicles in male sterility are well-grown, and the angle of inclination of them have a tendency to be small (on an average 27.3 degree). Author's original classification of type No. 5 is 5.5%. But tuberculous findings in seminal vesicles are seen in few cases, on the contrary the abnormal dilatation of main tubes found frequently. en-copyright= kn-copyright= en-aut-name=NambaKatsuichi en-aut-sei=Namba en-aut-mei=Katsuichi kn-aut-name=難波克一 kn-aut-sei=難波 kn-aut-mei=克一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部泌尿器科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=407 end-page=429 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Study of the Extrapyramidal Motor Syndrom A clinical study and the ChE activity on the brain of the parkinsonian rats and mice induced by some Phenothiazine-Derivatives and Bulbocapnine kn-title=実験的錐体外路症候群に関する研究 薬物により惹起されたParkinsonismusネズミの臨床ならびに基底核領域ChE活性の選択的阻害について en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) In order to study the experimental Parkinsonism, some Phenothiazine-Derivatives, e. g. Chlorpromazine 30 mg/Kg., Perphenazine 15 mg/Kg.. Trifluoperazine 5 mg/Kg.. Fulphenazine 5 mg/Kg.. Thioproperazine 10 mg/Kg.; and Bulbocapnine 15 mg/Kg. which had been used for study of the experimental catatonia customally, were injected into the peritoneum of the Cb-strain of male mice and the Wister-strain of male rats. Above 90% of the rats and mice showed parkinsonism after the abministration of these drugs. 2) The parkinsonian rats and mice showed sluggish movements, abnormal postures, catalepsia-like-syndroms e. g. passivity, negativism, fixation, rigidity of muscles, vegetative signs and tremor. Rigidity of muscles was objectively proved by application of the priciple of the Wartenberg's fixation of position test which was adopted to identify parkinsonism clinically and the principle of the Richter's grasp reflex and by appearence of the normal motor units at a strech reflex of the M. Gastrocunemius in the electromyography. 3) As the preliminary experiment, three methods to assay the activity of ChE were each compared using brain homogenates. These were the manometric assay by Ammon's method, the electrometric assay using "glass electrode" PH-meter by the modified Michel's method and the spectrophotometric assay by the modified Takahashi Shibata's method. Among these assay, the electrometric assay was the most accurate method to detect the activity of ChE of the brain. Following studies were carried out using this electrometric assay. 4) The ChE activity of the whole cerebrum of parkinsonian mice induced medicamentally was measured and compared with that of normals using the electrometric assay. All of the Phenothiazine-Derivatives inhibited the ChE activity of the whole cerebrum. But Bulbocapnine did not. 5) The brain of the parkinsonian Wister strain of male rats was separated into two parts. One included the cortical area, the another included the basal ganglia. The ChE activity of both parts was measured by the electrometric assay. In the parkinsonian rats induced by Phenothiazine-Derivatives, the ChE activity of the cortical area was within normal limits but that of the basal gangliar area was remarkably inhibited. Bulbocapnine exaggerated the ChE activity in the cortical parts, while contrastedly inhibited the ChE activity in the basal ganglia. 6) Referring to the correlation of the inhibitory effect and the structures of the Phenothiazine-Derivatives, -CF(3) base which was replaced with 3'-H on the phenothiazine nucleus, had a relatively higher inhibitory effect than the another. Piperazinyl base which attached to the side chain of the Phenothiazine nucleus, had also relatively higher imhibitory effects. 7) The problems occured here were discussed. Especially the correlation between parkinsonism and the possible roles of the cholinergic system, regarding to the change of the behavior of animals and the inhibition of the ChE activity or the basal ganglia of the parkinsonian rats were discussed. en-copyright= kn-copyright= en-aut-name=KurodaKunihiko en-aut-sei=Kuroda en-aut-mei=Kunihiko kn-aut-name=黒田邦彦 kn-aut-sei=黒田 kn-aut-mei=邦彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=811 end-page=820 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Serum Hepatitis Resulted from Blood Transfusion kn-title=輸血による血清肝炎について en-subtitle= kn-subtitle= en-abstract= kn-abstract=In recent years there have been many cases, with increasing frequency, of serum hepatitis resulted from blood transfusion. The purpose of this study was to investigate the incidence, clinical feature, prognosis and prophylaxis of serum hepatitis followed by blood transfusion. The results obtained were as follows; 1) Incidence of serum hepatitis among the patients who had blood transfusion at local institutions in Okayama City was 3.3% in 1957 and 4.7% in 1958, on the other hand, at Okayama University Hospital in 1958 it was 5.0% in the First Surgical Division, 5.4% the Second Surgery and 5.2% OBGYN respectively. The patients with serum hepatitis had received the amount 2,600 to 1,120 cc of blood, whereas 810 to 1,120 cc in the cases who never developed serum hepatitis after blood transfusion. 2) Mean incubation period was 72.8 days ranging 19 to 180 days calculated from the date of last blood transfusion. Prodremal stage varied from 1 to 20 days, average 6.1 days, icteric stage 7 to 15 days, average 35.8 days, and convalescent stage 7 to 200 days, average 30.0 days. 3) Characteristic initial symptoms were anorexia, malaise and jaundice by which fairly number of the cases noticed the onset of the disease. Few had febrile course but low grade in most of the cases. 4) Laboratory data were obtained from the 20 cases of serum hepatitis admitted to our First Mebical Division. Serum bilirubin showed the maximum level on the 10 th day, average 13.0 mg% . No significant changes were noted in peripheral blood picture but for a slight initial monocytosis. SGO-T and SGP-T presented a elevation earlier than that of serum bilirubin, maximum on or about the 5 th day and then decreased abruptly. Serum colloidal liver function tests; in initial stage, positive Takata's reaction in 51.%, positive CCF 46% and TTT 58% were noted, but even after 100 th day Takata's reaction was positive in 25% of the cases. 5) Follow-up studies were made on 49 serum hepatitis cases discharged from our hospital with complete recovery. 69% of these had subjective symptems in some sort or another. Enlargement of the liver was noted in 20% of the cases. 33 cases were studied with special reference to liver function tests and liver biopsy. It was revealed that 43% of the cases still had impairment of liver function and that by means of liver biopsy, postnecrotic cirrhosis was found 9.1% of the cases. Therefore, the prognosis of serum hepatitis of this type was considered to be grave. 6) For the purpose of prophylaxis, 300 to 600 mg of gamma globulin was simultaneously administered on blood transfusion in 38 cases. Inspite of this, 4 cases suffered from serum hepatitis later on, and no definite prophylactic effect of gamma globulin was noted. en-copyright= kn-copyright= en-aut-name=KosakaKiyowo en-aut-sei=Kosaka en-aut-mei=Kiyowo kn-aut-name=小坂淳夫 kn-aut-sei=小坂 kn-aut-mei=淳夫 aut-affil-num=1 ORCID= en-aut-name=NagashimaHideo en-aut-sei=Nagashima en-aut-mei=Hideo kn-aut-name=長島秀夫 kn-aut-sei=長島 kn-aut-mei=秀夫 aut-affil-num=2 ORCID= en-aut-name=YamabukiTakahiro en-aut-sei=Yamabuki en-aut-mei=Takahiro kn-aut-name=山吹隆寛 kn-aut-sei=山吹 kn-aut-mei=隆寛 aut-affil-num=3 ORCID= en-aut-name=YamamotoShigeru en-aut-sei=Yamamoto en-aut-mei=Shigeru kn-aut-name=山本繁 kn-aut-sei=山本 kn-aut-mei=繁 aut-affil-num=4 ORCID= en-aut-name=UedaYutaka en-aut-sei=Ueda en-aut-mei=Yutaka kn-aut-name=植田胖 kn-aut-sei=植田 kn-aut-mei=胖 aut-affil-num=5 ORCID= en-aut-name=EndoKenichi en-aut-sei=Endo en-aut-mei=Kenichi kn-aut-name=遠藤憲一 kn-aut-sei=遠藤 kn-aut-mei=憲一 aut-affil-num=6 ORCID= en-aut-name=KusudoHiroshi en-aut-sei=Kusudo en-aut-mei=Hiroshi kn-aut-name=楠戸宏 kn-aut-sei=楠戸 kn-aut-mei=宏 aut-affil-num=7 ORCID= en-aut-name=OnoNobuhiro en-aut-sei=Ono en-aut-mei=Nobuhiro kn-aut-name=小野延宏 kn-aut-sei=小野 kn-aut-mei=延宏 aut-affil-num=8 ORCID= en-aut-name=KobashiNobuo en-aut-sei=Kobashi en-aut-mei=Nobuo kn-aut-name=小橋暢夫 kn-aut-sei=小橋 kn-aut-mei=暢夫 aut-affil-num=9 ORCID= en-aut-name=AsadaKiyotaka en-aut-sei=Asada en-aut-mei=Kiyotaka kn-aut-name=浅田清隆 kn-aut-sei=浅田 kn-aut-mei=清隆 aut-affil-num=10 ORCID= en-aut-name=KajiMasayoshi en-aut-sei=Kaji en-aut-mei=Masayoshi kn-aut-name=加地正義 kn-aut-sei=加地 kn-aut-mei=正義 aut-affil-num=11 ORCID= en-aut-name=KitagawaToshinori en-aut-sei=Kitagawa en-aut-mei=Toshinori kn-aut-name=北川紀典 kn-aut-sei=北川 kn-aut-mei=紀典 aut-affil-num=12 ORCID= en-aut-name=ShinoharaToshio en-aut-sei=Shinohara en-aut-mei=Toshio kn-aut-name=篠原敏夫 kn-aut-sei=篠原 kn-aut-mei=敏夫 aut-affil-num=13 ORCID= en-aut-name=TakakiTadateru en-aut-sei=Takaki en-aut-mei=Tadateru kn-aut-name=高木直輝 kn-aut-sei=高木 kn-aut-mei=直輝 aut-affil-num=14 ORCID= en-aut-name=NishidaTakeshi en-aut-sei=Nishida en-aut-mei=Takeshi kn-aut-name=西田彪 kn-aut-sei=西田 kn-aut-mei=彪 aut-affil-num=15 ORCID= en-aut-name=NagoshiKazuma en-aut-sei=Nagoshi en-aut-mei=Kazuma kn-aut-name=名越一馬 kn-aut-sei=名越 kn-aut-mei=一馬 aut-affil-num=16 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=13 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=14 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=15 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=16 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=431 end-page=445 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies On Diencephalo-Pituitary-Adrenocortical Function in Depressive Psychosis 1. On Urinary Steroid Patterns kn-title=抑うつ状態における間脳-下垂体-副腎皮質系機能に関する研究 T. 尿中Steroid像について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although there are many reports concerning the endocrinological studies in mental diseases, no general agreement has yet been reached. Investigating the depressive psychosis, the author gave a special consideration to the problem whether there are any specific relations between the urinary corticoid patterns and clinical state. Twenty-four hour urines were collected from 20 males and 20 females, both healthy persons (ranging 22-47 years old in age, the average being adout 25 years) as controls, and 28 cases of depressive psychosis, consisted of 14 males and 14 females (ranging 22-68 years old, 42 years in average) composed of 4 reactive, 2 agitated and 5 brain arteriosclerotic depressive state. Measurements were taken on total neutral 17-ketosteroid (17-KS), total 17-hydroxycorticoid (17-OHCS) and free and conjugated forms of the latter. 17-KS was measured by the modified Holtorff and Koch's method and Bongiovanni's method. The results are as follows: (Every value shows mean and standard deviation). 1. Dialy excretion of total 17-KS in the controls was 7.63±2.71 mg/day for males and 5.67-1,67 mg/day for females. The difference between both sexes is thought to be significant from the statistical standpoint. Daily control excretion of 17-OHCS of males was 6.13±1.74 mg/day as the total amount, 0.88±0.51 mg/day as free form, 5.26±1.57 mg/day as conjugated form, 8.12±4.95 as the ratio of conjugated form/free form (C/F), and 86.18±6.28 as the percentage of conjugated form/total (C/T%); that of females was 5.48±2.07 mg/day as total, 0.65±0.42 mg/day as free form, 4.83±1.84 mg/day as conjugated form, 9.50±4.85 as C/F and 88.06±5.87 as C/T%. The difference between sexes appears to be insignificant. 2. Depressive group: Total 17-KS was 5.42±2.83 mg/day for males and 4.97±2.05 mg/day for females, being lower than normal value, and the former was significant but the latter insignificant from the statistical standpoint. Total 17-OHCS was 5.42±2.86 mg/day for males and 3.83±1.68 mg/day for females, being lower than normal value, which means that the former is insignificant while the latter significant. Free 17-OHCS was 2.17±1.18 mg/day for males and 1.19±0.82 mg/day for females, 2 times or more than normal value, and those of both sexes were significant. Conjugated 17 OHCS was 3.25±1.90 mg/day for males and 2.64±1.92 mg/day for females, lower than normal value, being significant for both sexes. 3. In comparing all the depressive groups with small groups of 2 agitated, 4 reactive and 5 cerebral arteriosclerotic depressives, there were no significant differences but the two agitated in the small groups showed the lowest values of all the depressives, namely, total 17-KS, total 17-OHCS, conjugated from and C/F ratio all proved to be much lower than those in the other depressives. 4. Total 17-OHCS values of 5 cases after treatment were found to have been increased, free 17-OHCS decreased, and conjugated form increased. As the result of the increase in the C/F and C/T % , the corticoid patterns approached the normal. 5. The author investigated the relation of corticoid patterns and liver dysfunction, then depressive psychosis and schizophrenia. Incomparing schrzophrenia with depressive psychosis, 17-KS value of the latter was found to approximate that of acute schizophrenics and total 17-OHCS value of the latter to that of chronic schizophrenics in both sexes. From these findings it seems that depressive psychosis indicates the diencephalo-pituitary-adrenccortical dysfunction more significantly than schizophrenia. en-copyright= kn-copyright= en-aut-name=TsujiHarunori en-aut-sei=Tsuji en-aut-mei=Harunori kn-aut-name=辻治憲 kn-aut-sei=辻 kn-aut-mei=治憲 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=821 end-page=830 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Sulfur Metabolism in Infants Part I. Some Suggestion for the Quautative Analysis of Total Sulfur in Milk, Faces and Urine and the Total Sulfur Contents in Various Milk kn-title=乳児の硫黄代謝に関する研究 第1編 乳汁,屎及び尿中の総硫黄定量法の考案並びに各種乳汁中の総硫黄量 en-subtitle= kn-subtitle= en-abstract= kn-abstract=There are numerous articles concerning the estination of total sulfur in organic substances and yet the results obtained hitherto are not by any means quite satisfactory. The gratest difficulty encountered in the estination of sulfur seems to lie in the insufficient ashing of the substance. Therefore, the author studied various ashing metheds and finally modified Bethge's wet ashing in the following manner: 1, Ammoniated vanadium (NH(4)VO(3)) is added as an oxidizing catalyst. 2. As an indicator of the complete oxidation potassium chromate (K(2)Cr(2)O(7)) is used. 3. The ratio of acid mixture is set in the proportion of three parts perohloric acid to two parts nitric acid. 4. The reduction mixture is placed into an ampule filled with pitrogan immediately after it is prepared and is sealed tightly, and the quantity of the mixture to be added is increased. By the modified method mentioned above it has been possible to raise the recovery rate of sulfur added as much as 95.4 per Gent, proving that this method is sufficiently useful for the estimation of the total sulfur in milk, urine and faces. In the estimations of total sulfur of various milk such as breast milk, milk on the market and 18% solution of regulated powered milk the average contents of total sulfur have been found to be 11.7 mg and 31.8 mg per dl respectively. en-copyright= kn-copyright= en-aut-name=HamadaGibun en-aut-sei=Hamada en-aut-mei=Gibun kn-aut-name=濱田義文 kn-aut-sei=濱田 kn-aut-mei=義文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部小児科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=831 end-page=844 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Sulfur Metabolism in Infants Part 2. The Sulfur Metabolism in Infants under Breast Feeding and in Infants under Artifical Feeding kn-title=乳児の硫黄代謝に関する研究 第2編 天然及び人工栄養児の硫黄代謝 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By the new method as described in Part I the author studied the sulfur and nitrogen metabolism in infants under breast feeding and in infants under artificial feeding, and obtained the following results. 1. In the infants under breast feeding at the age of 1-2 months, 3-4 months, and 5-6 months old the average sulfur retention at each period has bead 25.7, 33.7, and -0.53 per cent respectively. Similarly in the infants under artificial feeding at the same age range the average retenrion has beed 35.1, 48.6 and 40.4 per cent respectively. 2. In the case of the infants under breat feeding at the age of 5-6 months old the quantity of sulfur retained gives a negative value, but this seems to be due to an increased urinary excretion of sulfur in the process of the conversion of cartilage to bone. 3. The nitrogen retention rate shows no difference due to feeding methods. 4. Nitrogen-sulufr ratio (N/S) of the retention differs according to the method of feeding. Namely, the ratio N/S in infants under breast feeding is 25.2 while that in infants under artificial feeding is 18.8. 5. N/S values of the retention in infants under breast feeding are higher than those in infants under artificial feeding. This fact indicates that sulfur in breast milk is more effective than that in cow's milk for increasing the quantity of nitrogen to be retained, and this in turn seems to be due to the action of cystine-sulfur contained in breast milk. en-copyright= kn-copyright= en-aut-name=HamadaGibun en-aut-sei=Hamada en-aut-mei=Gibun kn-aut-name=濱田義文 kn-aut-sei=濱田 kn-aut-mei=義文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大挙医学部小児科学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=447 end-page=460 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Diencephalo-Pituitary-Adrenocortical Function in Depressive Psychosis U. On Blood Corticoid Patterns kn-title=抑うつ状態における間脳-下垂体-副腎皮質系機能に関する研究 U. 血中Steroid像について en-subtitle= kn-subtitle= en-abstract= kn-abstract=As the result of investigation of the urinary steroid patterns in depressive psychosis in previous communication, the author has been able to demonstrate the decreased excretion of total 17-ketosteroid (17-KS) and total 17-hydroxycorticoid (17-OHCS), increased excretion of free 17-OHCS and decreased excretion of conjugated 17-OHCS. Following these results, the ratio of conjugated form/ free form (C/F) and the percentage of conjugated form/total 17-OHCS (C/T%) seem to have very significant changes in comparison with those in the control. In the present study the author investigated 17-OHCS in plasma of depressive psychosis. The plasma specimens were secured from 10 males and 12 females, all healthy persons (in the age range of 18-47 years old and 23 years in average) for controls, and 12 male and 10 female depressives (ranging 22-64 years in age, the average being 41 years). Measurements were taken on total, free and conjugated forms of 17-OHCS by Nelson-Samuel's and Bongiovanni's methods and for the hydrolysis of conjugated form beef-liver β-glucuronidase was employed. The results are as follows: (Every value shows mean and standard deviation. 1. Total 17-OHCS values were 30.77±10.23 γg/dl for controls and 44.34±21.18 γg/dl for depressives, and those of free form were 10.36±5.00 γg/dl in controls and 23.88±11.17 γg/dl in depressives, those of conjugated form were 20.41±10.59 γg/dl in controls and 20.93±11.43 γg/dl for depressives and C/F ratio was 2.35±1.59 in controls and 0.95±0.48 in depressives. 2. In comparison with depressives and controls, the total 17-OHCS was higher than normal value, being significant from the statistical standpoint. The value of free form was about 2 times higher than the normal, showing significant difference between the two. The C/F ratio in depressives, however, was about half of the normal value. 3. In comparing all the depressives with the small groups of 4 reactive and 4 cerebral arteriosclerotic depressives, there could be found not any specific differences among them. 4. In the four cases with improvement after treatment it was found that total 17-OHCS was increased, free form decreased and conjugated form increased. As the result of these changes, C/F ratio was also increased and the corticoid pattern approached the normal value. 5. The decrease in C/F values was characteristic common both to schizophrenia and depressive, but a difference between the two was found in the fact that, whereas the C/F value was decreased due to a decrease in conjugated form in schizophrenia, it was diminished as the result of a marked increase in free form in the depressive. A discussion was made on the meaning of these findings. 6. In the comparative values of 17-OHCS in the blood and urine of 15 cases, measured simultaneously, it was found that the increase of free 17-OHCS in the blood induced an increase of the free 17-OHCS in the urine, thus directly causing the diminution of C/F value. In addition, it was clarified that an increase of total blood 17-0HCS did not necessarily mean its increase in the total urinary content, and also there was no parallel increase in its values of conjugated form in blood and in urine. In order to explain this point, a discussion was made on the role played by the diencephalon, hyophysis and liver function as well as on the pathological factors. en-copyright= kn-copyright= en-aut-name=TsujiHarunori en-aut-sei=Tsuji en-aut-mei=Harunori kn-aut-name=辻治憲 kn-aut-sei=辻 kn-aut-mei=治憲 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=845 end-page=854 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cytological Studies on the Aspirated Fluid with the Phase-Contrast Microscope Part 1. Cytological Studies on the Normal Ascites of Human and Various Animals kn-title=位相差顕微鏡(PCM)観察による穿刺液の細胞学的研究 第1編 人並びに各種動物の正常腹水の細胞学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Comparative studies were carried on the normal ascitic cells, especially on phagocytes that occupy the major portion of ascitic cells, aspirated from mammalians such as mice, rats, rabbits, dogs, cats, and human as well as from chicken by the pressure method with a phase contrast microscope and also with moving pictures of these various cells. As the results the following conclusions were arrived at: 1. The majority of mouse phagocytes have the characteristics similar to those of monocytes and histiocytes. 2. In the higher animals such as rats and rabbits a greater portion of them show flagellar pseudopodia and the aggregating tendency of highly reflactile granules and the distribution of mitochondria along the groove of the nucleus. And their nuclear membrane is thin and the nuclei are solid with a complicated shape, and the nuclear substance is soft but without any nucleoles. All of these findings become quite similar to those of monocytes, and in dogs and cats they can hardly be distinguished from monocytes. In the case of normal human phagocytes most of them show degeneration but even these cells reveal the characteristics very close to those of monocytes but far different from those of histiocytes. Even in the chicken phagocytes an unexpectedly large portion of them possess marked characteristics of monocytes. 3. As for the movement of these cells it is minimal, differing from blood monocytes this point, but it seems that this is due to the adaptation peculiar to the circumstances as ascites. From these findings it can be concluded that the ascitic cells possess characteristics far different from those of histiocytes but extremely similar to those of monocytes. en-copyright= kn-copyright= en-aut-name=KamuraJunta en-aut-sei=Kamura en-aut-mei=Junta kn-aut-name=嘉村淳太 kn-aut-sei=嘉村 kn-aut-mei=淳太 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=2 article-no= start-page=473 end-page=475 dt-received= dt-revised= dt-accepted= dt-pub-year=1933 dt-pub=19330228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=雜報 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山医学会 kn-aut-sei=岡山医学会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=461 end-page=472 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of Anti-leukemic Agents on Hematopoietic Functions of Bone Marrow 1. A Study on the Roller Culture Method of Bone-Marrow Cell Suspension kn-title=抗白血病剤の骨髄造血機能に及ぼす影響に関する研究 第1編 骨髄細胞浮游廻転培養法に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the purpose of a comparative study on the influences of various anti-leukemic agents on the erythropoietic function of bone marrow, a roller culture method was performed to culture the cell suspensions of human and rabbit bone marrow. In the course of the incubation, the author observed the changes in the erythrocyte counts, number of nucleated cells, hemoglobin content, percentage of orthochromic erythroblasts, and increment index of orthochromic erythroblasts. As the results, it has been recognized that in this culture method bone marrow erythroblasts mature and differentiate in the same fashion as in in vivo. Therefore, it is assumed that, when human or rabbit bone marrow is cultured by this method in the media containing chemical substances or sera, it is possible to observe their direct influences on the erythropoietic functions of bone marrow. en-copyright= kn-copyright= en-aut-name=SezakiTatsuo en-aut-sei=Sezaki en-aut-mei=Tatsuo kn-aut-name=瀬崎達雄 kn-aut-sei=瀬崎 kn-aut-mei=達雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=889 end-page=899 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Physiological Studies on the Metabolic Activities of Streptomycin-Resistant B. Dysentheriae. 1. The Carbohydrate Metabolism of Streptomycin-Resistant Sh. flexneri 2a kn-title=ストレプトマイシン耐性赤痢菌の生理学的研究 第1編 ストレプトマイシン耐性赤痢菌駒込BVの糖代謝 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The resistance to streptomycin should be demonstrated by some differencies in metabolic reactions detectable by comparisons made between resistant and susceptible bacteria. This paper is concerned with the examination of the glucose metabolism of streptomycin-susceptible and streptomycin-resistant strains of Sh. flexneri 2a. The resistant strains was obtained by serial transfers in progressive levels of streptomycin. This resistant variant could withstand at least 10,000γ per ml of streptomycin. 1) The oxidative abilitys of the resistant strains is considerably less on pyruvate among the components of the citric acid cycle than is that of the susceptible strain. 2) Pyruvic acid, lactic acid, and acetic acid accumulates during the oxidation of glucose by resistant and susceptible strains. The amount of pyruvic acid produced from glucose by resistant strain is more than that by susceptible strain. In the rate of consumptions of glucose between resistant and susceptible strains there is much less difference. 3) No significant difference between both strains is detected in anaerobic metabolism of glucose. 4) Resistant strains which has grown on continued subculture by serial transfer in the medium not containing streptomycin possess still these properties. This culture was also found to be resistant to at least 10,000γ per ml of streptomycin. 5) It is suggested that streptomycin-resistant and susceptible strains dissimilates glucose mainly by way of Embden-Myerhof pathway, and also have Warbung-Dickens pathway as an alternate pathway. 6) Streptomycin-susceptible strain growes more rapidly than streptomycin-resistant strain in shaking culture. 7) These results suggests that streptomycin-resistant strain is more fermentative in the metabolism of glucose than streptomycin-susceptible strain, and a significant difference between streptomycin-resistant and streptomycin susceptible strains exists in pyruvate metabolism and its terminal respiration system. en-copyright= kn-copyright= en-aut-name=KawaiKiyoshi en-aut-sei=Kawai en-aut-mei=Kiyoshi kn-aut-name=川井潔 kn-aut-sei=川井 kn-aut-mei=潔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=495 end-page=516 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of Anti-leukemic Agents on the Hematopoietic Functions of Bone Marrow 3. Influences of Various Anti-leukemic Agents on Thrombopoietic Function of Normal Human and Guinea Pig Bone Marrow kn-title=抗白血病剤の骨髄造血機能に及ぼす影響に関する研究 第3編 正常海?及び健康人骨髄栓球系造血機能に及ぼす各種抗白血病の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to compare the influences of various anti-leukemic agents on the bone marrow thrombopoiesis, the clinical tissue culture of bone marrow from normal guinea pigs and healthy persons was conducted. Various anti-leukemic agents were added to the culture media at the maximum concentration where they would not inhibit the bone marrow growth in culture, and observations were carried out to see the influences of these agents on the function of megakaryocytes of bone marrow. As the results, the author arrived at the follwing conclusions. 1. Urethane. Nitromin. Demecolcin, Actinomycin C and Mitomycin C inhibit the thrombopoietic function of bone marrow to a high degree. 2. Thio-TEPA, 8-Azaguanine, Carzinophilin, and Chromomycin demonstrate a moderate inhibitory action on the thrombopoietic function of bone marrow. 3. 6-MP slightly inhibits the thrombopoietic function of bone marrow. 4. Myleran, and the combined use of 6-MP and Prednisolone show no inhibitory effect on the thrombopoietic function of bone marrow. 5. On the other hand, Prednisolone alone rather augments the bone marrow thrombopoietic function. en-copyright= kn-copyright= en-aut-name=SezakiTatsuo en-aut-sei=Sezaki en-aut-mei=Tatsuo kn-aut-name=瀬崎達雄 kn-aut-sei=瀬崎 kn-aut-mei=達雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=901 end-page=913 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Physiological Studies on the Metabolic Activities of Streptomycin-Resistant B. dysentheriae U. The Pyruvate Metabolism and its Terminal Respiration System of Streptomycin-Resistant Sh. flexneri 2a kn-title=ストレプトマイシン耐性赤痢菌の生理学的研究 第2編 ストレプトマイシン耐性赤痢菌駒込BVのピルビン酸代謝と終末呼吸系 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Following the previous reports, the author carried out the experiment to elucidate the difference in the pyruvate oxidation and its terminal respiration system between resistant and susceptible Sh. flexneri 2a. 1) The oxidation rate of pyruvate by resistant strain is considerably less at every pH than by susceptible strain. The pH optimum for oxidation of pyruvate of resistant strain is pH 5.6-6.0, whereas that of susceptible strain is pH 7.0-7.5. 2) The consumption rate on pyruvic acid substrate by resistant strain is significantly less than by susceptible strain. 3) Both resistant and susceptible strains oxidizes pyruvic acid via succinate. Pyruvate accumulates during the oxidation of the tricarboxylic acid cycle intermediates such as succinate, malate, fumarate, α-ketoglutarate by resistant and susceptible strains. 4) Aspartic-glutamic transamination has been demonstrated in susceptible strain under aerobic condition with both aspartic acid and glucose added. 5) The oxidation of pyruvate of susceptible strain can be accerelated more rapidly by divalent metal ions such as Mg??, Fe??, Mn?? than that of resistant strain. 6) Panthotenate accerelates more reasonably the respiration of pyruvie acid by susceptible strain than by resistant strain. 7) The significance of these results in relation to the presence of the citric acid cycle in the organism is discussed, and it is considered possible that an significant difference in metabolic activities between resistant and susceptible strains exists in the metabolic pathway from pyruvate to succinate in the citric acid cycle. en-copyright= kn-copyright= en-aut-name=KawaiKiyoshi en-aut-sei=Kawai en-aut-mei=Kiyoshi kn-aut-name=川井潔 kn-aut-sei=川井 kn-aut-mei=潔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=517 end-page=521 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Tietze's Disease Results of new treatmeut with Steroids-hormon kn-title=副腎皮質ホルモンによるTietze氏病の新治療法について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The first description of the Tietze's disease was given in 1921 by Tietze himself. His presentation was based on a study of four personally observed patients, having a painful, non-suppurative swelling at the sternal end of the ribs. We don't have had the favorable treatment, including the surgical resection of ribs and deep x-ray therapy, however. Recently we had six cases with this syndrom in our department and gave the Hydrocortisone 25 to 50 mg or Predonine 5 to 10 mg by local injection, which showed the excellent results. Also preferable were the local anaesthesia with 2% Xylocain prior to steroid-injection and regional cold formentation for one or two days after steroid-injection. We have to differentiate this syndrom from other conditions and believe that this treatment is the first choice because of the simplicity of the procedure. en-copyright= kn-copyright= en-aut-name=MatsuuraUmeharu en-aut-sei=Matsuura en-aut-mei=Umeharu kn-aut-name=松浦梅春 kn-aut-sei=松浦 kn-aut-mei=梅春 aut-affil-num=1 ORCID= en-aut-name=YasuharaGoro en-aut-sei=Yasuhara en-aut-mei=Goro kn-aut-name=安原五郎 kn-aut-sei=安原 kn-aut-mei=五郎 aut-affil-num=2 ORCID= en-aut-name=SatoMinoru en-aut-sei=Sato en-aut-mei=Minoru kn-aut-name=佐藤実 kn-aut-sei=佐藤 kn-aut-mei=実 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部砂田外科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=915 end-page=919 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Comparative Study on the Tryptophan Metabolism of Streptomycin-sensitive and Streptomycin-resistant Shigella flexneri kn-title=赤痢菌のストレプトマイシン耐性変異とトリプトフアン代謝 en-subtitle= kn-subtitle= en-abstract= kn-abstract=There has been very little experimental work on the tryptophan metabolism of streptomycin-resistant bacteria. The authors performed this experiment in order to find out the differencies of the tryptophan metabolism between streptomycin-sensitive and streptmycin-resistant Shigella flexneri 2a. The results were as follows: 1. When streptomycin-resistant strains were grown in the streptomycin-containing medium, they have quantitatively lower tryptophanase activity than streptomycin-sensitive strains. 2. Streptomycin-resistant strains restores tryptophanase activity when streptomycin is absent in the growth medium, but they are resistant to streptomycin (10,000γ/ml). 3. Tryptophanase activity of both strains is inhibited slightly by divalent metal ions such as Mg, Fe, and Mn, but the inhibitive action of Cu is very remarkable. Natrium azide and arsenite have no effect. Vitamin B(6) and 2.4-dinitrophenol accerelates indole production from tryptophan by this organism. 4. Of the the various antibiotics aureomycin inhibits most markedly tryptophanase activity and chloromycetin does slightly, but streptomycin has no influence. 5. Tryptophanase is an adaptive enzyme, and considered to have essentially no relation to streptomycin-resistant mutation. en-copyright= kn-copyright= en-aut-name=KawaiKiyoshi en-aut-sei=Kawai en-aut-mei=Kiyoshi kn-aut-name=川井潔 kn-aut-sei=川井 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name=NishiiEmiko en-aut-sei=Nishii en-aut-mei=Emiko kn-aut-name=西井笑美子 kn-aut-sei=西井 kn-aut-mei=笑美子 aut-affil-num=2 ORCID= en-aut-name=TakahashiManabu en-aut-sei=Takahashi en-aut-mei=Manabu kn-aut-name=高橋学 kn-aut-sei=高橋 kn-aut-mei=学 aut-affil-num=3 ORCID= en-aut-name=HonmatuKakushi en-aut-sei=Honmatu en-aut-mei=Kakushi kn-aut-name=本松格史 kn-aut-sei=本松 kn-aut-mei=格史 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=523 end-page=532 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Fluorescence Staining of Cancer Cells and Cancer Chemotherapy with Concurrent Use of Surfactants 1. Staining Mechanism of Cancer Cells By Fluorescent NTS Dye kn-title=癌細胞の螢光染色ならびに界面活性物質を併用した癌化学療法の研究 第1編 螢光色素NTSによる癌細胞の染色機序に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the purpose of elucibating the staining mechanism of fluorescent NTS dye that deeply stains cancer cells, some model experiments were conducted using fluorescent NTS dye mixed with a variety of proteins to pursue the manner of staining by means of stripping method at varying pHs as well as by paper electrophoresis. In addition, staining of cells was performed with the use of Ehrlich ascites tumor cells, MH-134 ascites liver cancer cells, normal rabbit liver cells, normal rabbit leucocytes, lymph nodes and peripheral blood of gastric cancer bearing patients, and human pus, and the following results were obtained. 1. Static electrical binding seems to play a principal role in the combination of fluorescent NTS dye with various proteins. 2. Cancer cells are stained deeply with the fluorescent NTS dye at higher pH range as compared with normal cells. 3. From these findings it has been clarified that, although fluorescent NTS dye is a suitable material for staining cancer cells, as young cells with abundant basophilic proteins possess specificity, fluorescent NTS dye is not necessarily so satisfactory a material with respect to its specificity to cancer cells. en-copyright= kn-copyright= en-aut-name=MorishitaKazuo en-aut-sei=Morishita en-aut-mei=Kazuo kn-aut-name=森下和郎 kn-aut-sei=森下 kn-aut-mei=和郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=921 end-page=926 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Effect of Streptomycin on the Metabolic Activities of Bacteria kn-title=微生物の代謝に対するストレプトマイシンの作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This experiment was attempted to investigate the inhibitory action of streptomycin. The organism used is Shigella flexneri 2a. The results are as follows: 1) Even under a level of 200γ/ml streptomycin, it cannot inhibit the oxidation of pyruvate, succinate, fumarate, malate, glutamate, and aspartate by whole cell suspensions. 2) When glutamate is added to a cell suspension that has previously been permitted to oxidize fumarate, an immediate increase in oxygen consumption is observed. This increase is scarcely prevented by streptomycin. 3) The oxidatin of a mixture of glucose, glutamate, and 10(-3)M Mg(++) by a cell suspension is prevented by streptomycin level of 200γ/ml. 4) Streoptomycin prevents especially aerobic growth of this organism in the synthetic medium and results in an increased accumulation of pyruvate as a metabolic product. en-copyright= kn-copyright= en-aut-name=KawaiKiyoshi en-aut-sei=Kawai en-aut-mei=Kiyoshi kn-aut-name=川井潔 kn-aut-sei=川井 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name=MatsumotoToyozi en-aut-sei=Matsumoto en-aut-mei=Toyozi kn-aut-name=松本豊治 kn-aut-sei=松本 kn-aut-mei=豊治 aut-affil-num=2 ORCID= en-aut-name=HonmatsuKakushi en-aut-sei=Honmatsu en-aut-mei=Kakushi kn-aut-name=本松格史 kn-aut-sei=本松 kn-aut-mei=格史 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=7 article-no= start-page=1719 end-page=1722 dt-received= dt-revised= dt-accepted= dt-pub-year=1933 dt-pub=19330731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=雜報 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山医学会 kn-aut-sei=岡山医学会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=927 end-page=931 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Comparative Study on the Effect of Aureomycin, Chloromycetin, and Streptomycin on the Bacterial Respiration kn-title=微生物の呼吸に対するオーレオマイシン,クロロマイセチン及びストレプトマイシンの作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This experiment was performed to investigate the effect of aureomycin, chloromycetin, and streptomycin upon the oxidation of several substrates by Sh. flexneri 2a and E. coli communis. The results are as follows: 1) A level of 200γ/ml aureomycin markedly inhibits the oxygen uptake with substrates such as glucose, pyruvate, glutamate, and aspartate. The inhibitory rate has no relation to the preincubation time of a mixture of aureomycin and a cell suspension. 2) A high concentration (200γ/ml) of chloromycetin slightly inhibits the oxidation of amino acids such as glutamate and aspartate. The inhibitory rate has a relation to the preincubation time of a mixture of chloromycetin and whole cell suspensions. 3) A level of 200γ/ml streptomycin slightly inhibits the oxidation of glutamate and aspartate by E. coli, but it does not affect the oxidation of glucose and pyruvate by this organism. The oxidation of proposed substrates by Sh. flexneri 2a is not also prevented by streptomycin. Even though streptomycin is added to the original cell suspension before the substrates and preincubated for an hour, the results are the same. en-copyright= kn-copyright= en-aut-name=KawaiKiyoshi en-aut-sei=Kawai en-aut-mei=Kiyoshi kn-aut-name=川井潔 kn-aut-sei=川井 kn-aut-mei=潔 aut-affil-num=1 ORCID= en-aut-name=MatsumotoToyozi en-aut-sei=Matsumoto en-aut-mei=Toyozi kn-aut-name=松本豊治 kn-aut-sei=松本 kn-aut-mei=豊治 aut-affil-num=2 ORCID= en-aut-name=HonmatsuKakushi en-aut-sei=Honmatsu en-aut-mei=Kakushi kn-aut-name=本松格史 kn-aut-sei=本松 kn-aut-mei=格史 aut-affil-num=3 ORCID= en-aut-name=AkiyamaKengi en-aut-sei=Akiyama en-aut-mei=Kengi kn-aut-name=秋山健二 kn-aut-sei=秋山 kn-aut-mei=健二 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=533 end-page=538 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Fluorescence Staining of Cancer Cells and Cancer Chemotherapy with Concurrent Use of Surfactants 2. Quantitative Estimation of Nucleoprotein in Cancer Cells by Microspectrophotometer kn-title=癌細胞の螢光染色ならびに界面活性物質を併用した癌化学療法の研究 第2編 Microspectrophotometerによる癌細胞核蛋白の定量的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In his previous report (1) the author clarified that fluorescent NTS dye stains cancer cells more deeply at higher pH (pH 11.0) than normal cells and deduced the main reason for this to be due to the increased amount of nucleoprotein and a higher electrical potential of cancer cells. However, there emerges a question whether the amount of nucleoprotein of cancer cells is actually increased and this neads to be settled by quantitative estimation of basophilic protein per cell. Therefore, in order to ascertain this point, basophilic protein of Ehrlich ascites tumor cells, MH-134 ascites liver cancer cells. HeLa cells in culture, lymph nodes of gastric cancer bearing patients, and peripheral luecocytes of normal mice were stained with acid fast green FCF stain by Alfert's method, and the quantitative estimation of the protein per cell was conducted with microspectrophotometer. As the result it was confirmed that these cancer cells contain a larger quantity of the basic protein than lymph node. From these findings it has become clear that the fluorescent XTS. which is an acidic dye, stains cancer cells at a higher pH than normal cells because they contain a greater amount of basic protein than normal cells. en-copyright= kn-copyright= en-aut-name=MorishitaKazuo en-aut-sei=Morishita en-aut-mei=Kazuo kn-aut-name=森下和郎 kn-aut-sei=森下 kn-aut-mei=和郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=933 end-page=942 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A CLINICAL STUDY OF THE INTRAVENOUS THIAMYLAL SODIUM ANESTHESIA FROM THE STANDPOINT OF THE BLOOD AND INTERSTITIAL FLUID PART I CHANGES IN BLOOD AND INTERSTITIAL FLUID BY INTRAVENOUS THIAMYLAL SODIUM ANESTHESIA kn-title=体内水分電解質分布とThiamylal Sodium静脈麻酔との関係に関する臨床的研究 第1編 Thiamylal Sodium静脈麻酔前後における体内水分電解質分布の変動について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Twenty-one patients were anesthetized by intravenous injection of thiamylal sodium and changes in blood and interstitial fluid were observed before and after anesthesia. 1) The specific gravity of blood and plasma, plasma protein and hematcrit slightly increased after intravenous administration of thimylal sodium, while the water content of blood and pleasma decreased. 2) Among the plasma electrolytes, plasma nartrium and chloride decreased, while plasma pottasium increased. 3) A decrease of plasma volume and an increase of interstitial fluid were observed. 4) The changes of factors mentioned above is regarded to be caused not only by blood concentrasion but also by transmission of plasma fluid to extracellular fluid. en-copyright= kn-copyright= en-aut-name=MatsudaSumizo en-aut-sei=Matsuda en-aut-mei=Sumizo kn-aut-name=松田住蔵 kn-aut-sei=松田 kn-aut-mei=住蔵 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1(陣内)外科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=875 end-page=882 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=La Respiration de la Chauve-Souris pendant l'Hibernation kn-title=冬眠中ノ蝙蝠(Chiroptera)ノ瓦斯代謝ニ及ボス環境温度ノ影響ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=L'auteur examine sur l'influence que la temp?rature ambiante excerce sur l'intensit? de la respiration de la Chauve-Souris pendant l'hibernation. Les resultats sont ainsi qu'il suit: 1) Pendant la p?riode d'hibernation, la quantit? d'oxyg?ne absorb? et d'acide carbonique exhal? et le chiffre du quotient respiratoire, chez la Chauve-Souris, augmente et diminue avec la temp?rature ambiante. 2) En jugeant au point du vue de la respiration, l'?tat l?thargique est tr?s profond et stable ? la temp?rature basse (au-dessous de 10°C). Mais, au dessus de 10°C, le sommeil est variable et superficiel, et l'animal reveille entre 15-20°C. L'?change gazeux est ?normement augmente, pendant le reveil d'hibernation, avec aussi en croissant le quotient respiratoire. en-copyright= kn-copyright= en-aut-name=KosakaHisasi en-aut-sei=Kosaka en-aut-mei=Hisasi kn-aut-name=小坂壽 kn-aut-sei=小坂 kn-aut-mei=壽 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學生理學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=943 end-page=949 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A CLINICAL STUDY OF THE INTRAVENOUS THIAMYLAL SODIUM ANESTHESTA FROM THE STANDPOINT OF THE BLOOD AND INTERSTITIAL FLUID PART II THE RELATIONSHIP BETWEEN THE ANESTHESIA DURATION AFTER ADMINISTRATION OF THIAMYLAL SODIUM AND BLOOD AND INTERSTITAL FLUID kn-title=体内水分電解質分布とThiamylal Sodium静脈麻酔との関係に関する臨床的研究 第2編 体内水分電解質のThiamylal Sodium静脈麻酔における麻酔時間に及ぼす影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Twenty-one patients were anesthetized by intravenous injection of thiamylal sodium and the relationships between the duration of anesthesia and the blood and interstitial fluid were studied. 1) A parallel correlation was seen between the anesthesia duration and the water content of plasma. 2) A reverse correlation was found between the sleeping time of anesthesia and quantity of the total plasma protein. 3) No interrelatiohships were found between the duration of anesthesia and hematerit, water content of blood, serum natrium, serum chloride, serum pottasium and plasma volume. 4) A reverse correlation was seen between the sleeping time of anesthesia and the interstitial fluid volume. en-copyright= kn-copyright= en-aut-name=MatsudaSumizo en-aut-sei=Matsuda en-aut-mei=Sumizo kn-aut-name=松田住蔵 kn-aut-sei=松田 kn-aut-mei=住蔵 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1(陣内)外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=539 end-page=551 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Fluorescence Staining of Cancer Cells and Cancer Chemotherapy with Concurrent Use of Surfactants 3. Accelerative Effect of Various Surfactants on the Permeability of Cancer Cell Membrane kn-title=癌細胞の螢光染色ならびに界面活性物質を併用した癌化学療法の研究 第3編 諸種界面活性物質の癌細胞膜透過性亢進作用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In previous reports 1 and 2, the author experimentally verified te fundamental staining mechanism of fluorescent NTS dye by its deposits in various cells. In the present experiment an attempt has been made to see whether it is possible to perform supra-vital staining with this fluorescent NTS dye. At the same time observations have been carried out on the staining behaviors (or changes) induced by the accelerated permeability of cell membrane in the course of supra-vital staining with concurrent use of various surfactants (surface active substances), and the results are summarized as follows. 1, It has been found that flurorescent NTS dye, being an acidic dye, has affinity to denatured protein, revealing a staining mechanism similar to eosin, and it stains degenerated cells deeply. 2. It has also been elucidated that in the course of supra vital staining with acidic dyes such as fluorescent NTS dye and eosin, even when the medium pH is raised to 7.2, on the addition of such surfactants as Tween 80, saponin, osvan, linoleic acid, OX (an anti-tumor agent of unsaturated fatty acids from Xray-irradiated rabbit liver) the dye readily permeates the cell membrane and thus the entire cell is uniformly stained positively. 3. These surfactants accelerate the permeability of the dye through the cell membrane as their concentration is raised, but in the case with saponified solution of fatty acids such as linoleic acid and OX at a certain range of concentration they bind chemically with intracellular organellae, bringing about changes in protein electrical charge of the organellae and as the result the cell becomes no longer stainable. Therefore, this point needs to be taken into consideration when the supra-vital staining of cells is attempted with concurrent use of surfactants of fatty acid series. 4. With fluorescent NTS dye and eosin supra-vital staining has been tried on Ehrlich ascites tumor cells, liver cells, epithelial cells of intestine, and ascites cells. It has been demonstrated that there is at least some difference in the accelerative effect of surfactants on the permeability of cell membrane depending on the kind of the substances. The accelerating effect of osvan, which is cationic surfactant, is especially marked. In the case of Tween 80 (a non-ionic surfactant) its effect is weak. In the case of OX. it imparts a greater permeability to Ehrlich ascites tumor cells rather than to epithelial cells of intestine. From these results, it seems that to a certain extent the basis has been established for introducing selectively some of charged substances into tumor cells depending upon the use of these surfactants. en-copyright= kn-copyright= en-aut-name=MorishitaKazuo en-aut-sei=Morishita en-aut-mei=Kazuo kn-aut-name=森下和郎 kn-aut-sei=森下 kn-aut-mei=和郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=883 end-page=891 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber die Portioleukoplakie kn-title=子宮腟部「ロイコプラキー」ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Eine besondere Bedeutung haben in neuester Zeit durch die Forschungen von Hinselmann die als Leukoplakie bezeichneten Befunde der Portio erhalten. Es handelt sich dabei um weisslich gef?rbte Bezirke auf der Schleimhaut der Portio, deren Farbe durch verhornende Massen des Portioepithels bedingt ist und die man meistens schon makroskopisch erkennen kann. Hinselman hat sie mit dem Kolposkop eingehend erforscht. Es liegen auch bereits eine Anzahl einwandfreier Beobachtungen durch Hinselmann selbst und andere Autoren vor, die den ?bergang von Leukoplakie zum Karzinom sicher erweisen. Wenn man aber die Literatur durchsieht, ist man erstaunt ?ber die geringe Ausbeute an Portioleukoplakie. In Japan ist nur ein einziger Fall mitgeteilt. Ich hatte drei in unserer Klinik zur Behandlung vorliegende F?lle klinisch, makroskopisch und histologisch genau untersucht. Mikroskopisch fand sich ein wahres Stratum corneum mit stark abgeplatteten Epithelien, darunter ein Stratum granulosum und ein stark verdicktes Stratum Malpighi. Das basale Relief des erkrankten Teils ist stellenweise unruhiger als in den normalen Abschnitten. Es bestand auch bereits in Form von einzelnen Zapfenbildungen eine gewisse Neigung zur Wucherung ins subepitheliale Bindegewebe. Meine Erfahrungen legen uns die Pflicht auf, schon allein unter klinischen Gesichtspunkten den Portioleukoplakien eine besondere Bedeutung f?r die Fr?herkennung des Karzinoms beizumessen. Ob die 100%ige karzinomat?se Entwicklung der Leukoplakie sich in Zukunft wird halten lassen, ist nicht die wesentliche Frage. M?gen es auch nur 50% oder noch weniger sein, unter allen Umst?nden w?rden immer solche Stellen entfernt werden m?ssen, da wir es der Leukoplakie nicht ansehen k?nnen, wie ihre Weiterentwicklung sein wird und nicht daf?r garantieren k?nnen, dass die Frau in Kontrolle bleibt. en-copyright= kn-copyright= en-aut-name=YamamotoHideo en-aut-sei=Yamamoto en-aut-mei=Hideo kn-aut-name=山本英雄 kn-aut-sei=山本 kn-aut-mei=英雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學産婦人科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1342 end-page=1349 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ein Fall von operierter Felsenbeingeschwulst kn-title=顳?骨岩様部腫瘍ノ1新種 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Es handelt sich um einen Fall von rechtsseitiger Felsenbeingeschwulst, dessen Diagnose klinisch, namentlich radiologisch klar gestellt wurde. Die Operation fand ganz frei im Felsenbeink?rper eine Tumormasse, die in histologischen Hinsichten zur Gruppe Verocays Neurinom geh?rt. en-copyright= kn-copyright= en-aut-name=IshijimaTatsu en-aut-sei=Ishijima en-aut-mei=Tatsu kn-aut-name=石島達 kn-aut-sei=石島 kn-aut-mei=達 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學精神病學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=892 end-page=898 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber die Einfl?sse der ophthalmologischen Behandelungen zur Vitalf?rbbarkeit des vorderen Augengewebes (III. Mitteilung.) Operative Momente kn-title=臨牀的眼處置ノ前眼部組織ノ生體染色性ニ及ボス影響ニ就テ 第3報 手術的處置 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verfasser hat vorher im ersten Kapitel die Einfl?sse der pharmakologischen Behandlungen und im zweiten der physikalischen auf die Vitalf?rbbarkeit des Vorderaugengewebes mitgeteilt. In diesem dritten hat er ?ber bie Einfl?sse der Paracentese und der Sclerotomia posterior auf die desselben ebenfalls mit den Kaninchen experimentiert und daraus folgende Schl?sse gezogen. 1) Sowohl Paracentese, als auch Sclerotomia posterior bef?rdern die Vitalf?rbbarkeit des Vorderaugengewebes. 2) Die in diesem Experiment nachgewiesene Vitalf?rbbarkeitsbef?rderung ist wohl haupts?chlich als Folge des entz?ndlichen Reizes, d. h. Verst?rkung des Farbstoff speicherungsverm?gens und der Farbstoffkonzentration im Ortsgewebe, betrachtet zu werden. en-copyright= kn-copyright= en-aut-name=OhmoriSo en-aut-sei=Ohmori en-aut-mei=So kn-aut-name=大森操 kn-aut-sei=大森 kn-aut-mei=操 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學病理學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=951 end-page=958 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of OX (unsaturated fatty acidextract) on Ehrlich's Ascites Tumor cells kn-title=工ールリッヒ癌に及ぼすOXの影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=In view of the fact that there may be two possible actions in radiation distrurbaces in vivo, namely, one acting directly and the other acting indirectly, and on the assumption that these actions, persisting quite a long time after irradiation, induce specific substance in the irradiated nimals, Yamamoto of our department, has succeeded in isolating unsaturated fatty acid substance (OX) specific to the irradiated animals. With the purposa to find out what influences this substance (OX) will have on Ehrlich's ascites tumor cell, the author studied its effect on the number, mitotic phases and DNA ontents of the cancer cells. Test animals used are 80 mice each wighing about 15-20g. To these animals 0.2cc cell suspension of Ehrlich's ascites tumor cell is transplanted intraperitoneally and one week after the transplantation 0.2cc of 2%-, 1%-, 0.5%- OX substance is injected intrapeitoneally to these animals. By observing the changes in the cell counts, mitotic phase, and the DNA contents in each cell (with spectrophotometry) at the intervals of 1, 3, 6, 9, 12, and 24 hours after the injection of OX substance, and the following results were obtained: The number of cancer cells has been found markedly decreased; nomely, after one hour it is down to 78 per cent of the original count; down to 44per cent after 9 hours; and clown to 46.2 per cent after 24 hours. As for the mitotic phases, metaphase, anaphase telophase have been increased and the number of cells undergoing mitosis is diminished. Moreover, as for the DNA contents per cell, there can be observed an increase ni the number of cells with a markedly small amount of DNA, while the cells undergoing duplication due to mitosis have been found decreased in number. From these facts it is concl ded that OX substance acts on Ehrlich's ascites tumor cells as to induce the following disturbances: (1) cell destruction, (2) impairment of the activity in mitotic apparatus, (3) disturbance of the DNA synthesis, and (4) elicits atypical cell divistion. en-copyright= kn-copyright= en-aut-name=ItamiMotoya en-aut-sei=Itami en-aut-mei=Motoya kn-aut-name=伊丹尤也 kn-aut-sei=伊丹 kn-aut-mei=尤也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=959 end-page=993 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Effect of Respiratory Enzyme Inhibitors on Infection of Rickettsia kn-title=各種呼吸酵素阻害剤のRickettsiaの感染に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using several kinds of respiratory enzyme inhibitors, the author studied the effect of the inhibitors on infection of rickettsia to mouse. The investigations were carried out in vitro and in vivo and the observations were made from day to day. Moreover, the characters of rickettsia were investigated by the re-inoculation to normal mouse from the culture. The following results were obtained. 1) The infection of rickettsia were found to be suppressed by previous in vitro treatment of rickettsia with any enzyme inhibitors tested, but the suppression effect was varied by hind of inhibitors, its concentration, duration of its action and the concentration of rickettsial suspension. The infection capacity of enzyme inhibitor treated-rickettsia showed a decrease in cases of 5 hours treatment of 10-20 mg malonate, of 1.0 mg monojodo acetic acid or of 1.0 mg fluoride. However, the affection of these inhibitors was vary specific, and found to have caused merely a reduction of infection capacity or a suppression of infection instead of to caused an inactivation of rickettsia. 2) On the contrary the inhibitors did not show an inhibitory effect to the infection of the rickettsia, if the inhibitors were administrated to the mouse to be tested before the attack of rickettsia. Accordingly a fairly difinite infection and the successive multiplication of rickettsia were observed on the previousely inhibitor-treated mouse; upon rare occasions the infection was found to be severe on these treated mouse. 3) The effect of inhibitors also studied by obeorving properties of re-inoculated rickettsia to normal mouse, the rickettsia was taken from the culture on the previously inhibitor-treated mouse. The multiplication of re-inoculated rickettsia was measured by means of LD(50) curve, and was demonstrated that the appearance of symptomes and the days to death after the infection was somewhat delayed on the treated animal compared to the control; but the occurences were almost in the same way as in the control except a short delay of the time. Hence, the affected metabolism of host cell and metabolic system of animal required to multiplication of the rickettsia were supposed to show so much definite effect to the suppression of infection. en-copyright= kn-copyright= en-aut-name=KiyotoMasahiro en-aut-sei=Kiyoto en-aut-mei=Masahiro kn-aut-name=清遠正博 kn-aut-sei=清遠 kn-aut-mei=正博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=899 end-page=907 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Einfluss der Narkotica auf die Wirkung des Veratrin, Cocain und Pikrotoxin auf den D?nndarm in situ bei Kaninchen kn-title=「ヴエラトリン」,「コカイン」及ビ「ピクロトキシン」ノ生體家兎腸管ニ於ケル作用ニ及ボス麻痺毒ノ影響ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=In der vorigen Mitteilung wurde nachgewiesen, dass Veratrin, Cocain und Pikrotoxin auf den im K?rper befindlichen D?nndarm des Kaninchens in kleineren Dosen eine hemmende Wirkung aus?ben, welche auf die Erregung der hemmenden Zentren von sympathischer Natur zur?ckgef?hrt werden kann. Die hemmende Wirkung dieser Gifte wird verst?rkt, wenn dem Tiere voher Urethan, Paraldehyd und kleinere Dosen von Chloralhydrat verabreicht werden. Dagegen wird diese v?llig beseitigt und macht einer erregenden Wirkung Platz, wenn das Tier mit Luminal, Veronal und gr?sseren Dosen von Chloralhydrat vorbehandelt wird. Auf Grund diese Tatsachen und der Analogie betreffs des Wasser-und Zuckerzentrums kann mit Wahrscheinlichkeit angenommen werden, dass die hemmenden Zentren f?r den Darm sich im Zwischenhirn befinden, wo sie durch sog. Basisnarkotica gel?hmt werden, und dass die L?hmung der Hirnrinde durch die sog. Rindennarkotica eine Erregung der betreffenden Zentren zur Folge hat. en-copyright= kn-copyright= en-aut-name=KunishoKaoru en-aut-sei=Kunisho en-aut-mei=Kaoru kn-aut-name=國正薫 kn-aut-sei=國正 kn-aut-mei=薫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學藥理學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=3 article-no= start-page=995 end-page=998 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Hemolytic, Anemia-Inducing Substance in Cancer Tissue kn-title=癌組織中の溶血性細胞毒に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=In 1959 we discovered that a hemolytic, anemia-inducing substance is produced in the animals exposed to X-rays. Since then we have found that when this substnce is injeted intravenously into animals, there occur disturbances in the blood, spleen and bone marrow. And also it has become clear that this substance brings about Heinz's body appearance in erythrocytes. As Heinz's body also appears in cancer anemia and it is transformed into hemolysin, it may be assumed that the hemolytic, anemia-inducing substance is contained also in cancer tissue. Upon such assumption we have compared the hemolytic capacity of the extract obtained from the fresh gastric cancer tissue resscted at operation with that of the extract from normal gastric tissue. As the result, we have recognized that this hemolytic, anemia-inducing substance is contained considerably in cancer tissue. en-copyright= kn-copyright= en-aut-name=YamamotoMichio en-aut-sei=Yamamoto en-aut-mei=Michio kn-aut-name=山本道夫 kn-aut-sei=山本 kn-aut-mei=道夫 aut-affil-num=1 ORCID= en-aut-name=NobukiSigeo en-aut-sei=Nobuki en-aut-mei=Sigeo kn-aut-name=信木茂生 kn-aut-sei=信木 kn-aut-mei=茂生 aut-affil-num=2 ORCID= en-aut-name=SiakuTakeru en-aut-sei=Siaku en-aut-mei=Takeru kn-aut-name=塩飽健 kn-aut-sei=塩飽 kn-aut-mei=健 aut-affil-num=3 ORCID= en-aut-name=AkagiKeiko en-aut-sei=Akagi en-aut-mei=Keiko kn-aut-name=赤木瑩子 kn-aut-sei=赤木 kn-aut-mei=瑩子 aut-affil-num=4 ORCID= en-aut-name=SiakuMidori en-aut-sei=Siaku en-aut-mei=Midori kn-aut-name=塩飽緑 kn-aut-sei=塩飽 kn-aut-mei=緑 aut-affil-num=5 ORCID= en-aut-name=IgutiYosiko en-aut-sei=Iguti en-aut-mei=Yosiko kn-aut-name=井口与志子 kn-aut-sei=井口 kn-aut-mei=与志子 aut-affil-num=6 ORCID= en-aut-name=TanimotoJunichi en-aut-sei=Tanimoto en-aut-mei=Junichi kn-aut-name=谷本潤一 kn-aut-sei=谷本 kn-aut-mei=潤一 aut-affil-num=7 ORCID= en-aut-name=KojimaSumikazu en-aut-sei=Kojima en-aut-mei=Sumikazu kn-aut-name=小島澄一 kn-aut-sei=小島 kn-aut-mei=澄一 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=553 end-page=564 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Fluorescence Staining of Cancer Cells and Cancer Chemotherapy with Concurrent Use of Surfactants 4. Influences of Surfactants on the Effect of Antitumor Agents kn-title=癌細胞の螢光染色ならびに界面活性物質を併用した癌化学療法の研究 第4編制癌剤の抗腫瘍性に及ぼす界面活性物質の影響に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the previous papers it was reported that surfactants (surface active substances) accelerate the permeability of the cell membrane. This paper describes the results of several experiments, conducted on the assumption that, when the permeability of the cell is artificially accelerated with surfactants, some of anti-tumor agents would have more ready access into cancer cells, resulting in a greater anti-tumor effect. The results may be summarized as follows. 1. In intraperitoneal injections of saponified surfactants such as Tween 80, saponin, osvan, and OX, no marked prolongation of survival can be observed, except with OX, but the similar injections of Mitomycin C combined with Tween 80 or OX clearly show an enhanced anti-tumor effect. In other words, Mitomycin C administered in conjunction with Tween 80 or OX seems to be more readily introduced into carcinoma cells. On the other hand, there is no appreciable effect in the concurrent use of Thio-TEPA with surfactants. 2. When the peritoneal cavity of the mice is washed with the mixed solution of Mitomycin C and Tween 80 or with that of Mitomycin C and OX soon after transplantation of Ehrlich ascites carcinoma (after the lapse of 4 hours and 48 hours), likewise a marked prolongation of survival has been observed. In short, clinically at the suture following the gastric cancer resection, it is reasonable to assume that the washing of the peritoneal cavity with the mixture of Mitomycin C and surfactant solution would help to bring about a better prognosis. 3. Actually, when the mixed solution of Mitomycin C and surfactant is diffusely injected at the site of the tumor of superficial type in the patient bearing mammary recurrent cancer, a dramatic effect has been atained on the tumor without injury to normal tissues. As has been described in the foregoing, anti-tumor agents, when used along with surfactants, have been verified, experimentally and clinically, to accelerate the permeabilty of the cancer cell membrane, resulting in a more ready access of the anti-tumor agent into the cancer cells. en-copyright= kn-copyright= en-aut-name=MorishitaKazuo en-aut-sei=Morishita en-aut-mei=Kazuo kn-aut-name=森下和郎 kn-aut-sei=森下 kn-aut-mei=和郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=908 end-page=915 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber den Einfluss der Hirnstamm- und Hirnrindennarkotica auf die Blutzuckerregulation (II. Mitteilung.) ?ber den Einfluss auf die Hyperglyk?mie durch Adrenalin und Glukoseninfusion, sowie auf die Insulinhypoglyk?mie kn-title=腦幹及ビ皮質麻醉藥ノ血糖調節作用ニ及ボス影響ニ就テ(第2報)末梢性過血糖竝ニ「インシユリン」低血糖ニ及ボス影響ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=In der vorigen Mitteilung wurde berichtet, dass Veronal und Luminal auf das Zuckerzentrum im Hirnstamm l?hmend wirken, w?hrend Urethan und Chloralhydrat es nicht l?hmen. In der vorliegenden Arbeit wurde am Kaninchen der Eiufluss dieser Gifte auf die Hyperglyk?mie durch Adrenalin und Glukoseninfusion sowie auf die Hypoglyk?mie durch Insulin untersucht. 1) Veronal und Luminal verst?rken die Hyperglyk?mie durch Adrenalin und Glukoseninfusion sowie die Hypoglyk?mie durch Insulin. 2) Urethan und Chloralhydrat ?ben auf die Hyperglyk?mie durch Adrenalin und Glukoseninfusion keinen deutlichen Einfluss aus, auf die Insulinhypoglyk?mie wirken sie antagonistisch. Aus obigen Tatsachen k?unte gefolgert werden: dem Zuckerzentrum kommt eine Funktion zu, die Hyperglyk?mie durch Adrenalin bzw. Glukoseninfusion sowie die Hypoglyk?mie durch Insulin antagonistisch zu regulieren; Veronal und Luminal heben durch ihre l?hmende Wirkung auf das Zuckerzentrum diese regulierende Funktion des Zuckerzentrums auf. Urethan und Chloralhydrat zeigen in den angegebenen Dosen keine solche Wirkung, was daraufhindeutet, dass sie auf das Zuckerzentrum nicht l?hmend wirken. en-copyright= kn-copyright= en-aut-name=TachibanaKatsuo en-aut-sei=Tachibana en-aut-mei=Katsuo kn-aut-name=橘捷夫 kn-aut-sei=橘 kn-aut-mei=捷夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學藥理學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=916 end-page=960 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studien ?ber die Entwicklung der Nierenanlage, besonders uber die morphologischen Verh?ltnisse bei Kaninchenembryonen kn-title=腎臟原基ノ發生ニ就テ 家兎胎兒ニ於ケル檢索 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Schon seit langer Zeit wurden ?ber die Entwicklung der Nierenanlage von vielen Autoren allerhand Forschungen angestellt, leider ist diese jedoch in vielen Punkten morphologisch noch nicht erkl?rt. Ich habe daher unter der Leitung von Herrn Prof. Shikinami Untersuchungen ?ber die morphologische Entwicklung der Kaninchenembryonen vorgenommen, bei denen ich als Material 40 St?cke benutzte, die ich der Bequemlichkeit halber in 12 Stadien einteilte. Mit dem Material wurde nach der in unserem Laboratorium gew?hnlich angewandten Methode verfahren, es wurde n?mlich Fixierung in Zenker's L?sung oder Formol, St?ckf?rbung mit Borax-Karmin, Einbettung in Paraffin vorgenommen und es wurden Serienschnitte von 10μ Dicke angefertigt. Die wichtigen Teilen dieser Serienschnitte wurden mitels des Edinger'schen Zeichenapparates 75-150 fach vergr?ssert und nach Born-Peter'schen Verfahren als genaue Rekonstruktionsmodelle hergestellt. Diese rekonstruierten Modelle wurden mit mikroskopischen Beobachtungen verglichen, und es ergaben sich folgende Resultate: Wie bei V?geln und anderen S?ugetieren stammen auch bei Kaninchen die Sekretions- und Ausleerungssysteme aus zwei Mutterb?den, und besonders. 1) Die Nieren-Knospe, die erste Anlage des Ausleerungssystems, bildet sich. zuerst beim etwa 4.5mm langen, 37 Ursegmente aufweisenden Embryo, 11 Tage nach der Begattung, an der dorsomedialen Wand der Endstelle des Urnierenganges aus, bevor der Urnierengang in die Kloake ausm?ndet. 2) Die Nierenknospe verl?ngert sich allm?hlich, ihr Ende vergr?ssert sich auch, und es lassen sich morphologisch das prim?re Nierenbecken und der Ureter voneinander unterscheiden, wie es bei einem etwa 6.5mm langen Embryo mit 48 Ursegmenten, wenn 12 Tage nach der Begattung verlaufen sind, bemerkt wird. 3) Der Ureter verl?ngert sich kranialw?rts und geht ungef?hr in die Mitte des Nierenbeckens ?ber. Dieser ?bergangsteil kehrt sich anfangs ventralw?rts, aber wegen der Drehung der Nierenanlage allm?hlich nach innen. Caudalw?rts m?ndet der Ureter urspr?nglich an der dorsomedialen Seite der Endstelle des Urnierenganges aus, aber gem?ss dem Fortschritte der Entwieklungsstadien verschiebt sich seine Ausm?ndung auf die dorsale Seite, kommt zugleich allm?hlich in die N?he der Kloake und ?ffnet sich schliesslich beim 13.0mm langen Embryo, 15 Tage nach der Begattung, unabh?ngig von dem Urnierengange in dieselbe. Diese Lageverschiebung der Ureterm?ndung ist dadurch bedingt, dass sich die R?hrenwand des Caudalteils des Urnierenganges zur Kloakenwand mit dem Entwicklungsfortschritte der Kolake vergr?ssert. 4) Beim 8.5mm langen Embryo von 14 Tagen gehen prim?re Sammelr?hre von dem Nierenbecken aus, ihre Ausgangsmassnahmen sind aber unregelm?ssig, bis 4 Paar Sammelr?hre von der ventralen und dorsalen Seite des Nierenbeckens typisch vorspringen. 5) Wenn 4 Paar Sammelr?hre typisch vorspringen, gehen wieder neue prim?re Sammelr?hre von den kranialen und caudalen Endst?cke des Nierenbeckens aus. Und diese prim?ren Sammelr?hre produzieren weiter sekund?re und terti?re Sammelr?hre, wie es beim 13.0mm langen Embryo von 15 Tagen bemerkt wird. 6) Die Verzweigung der Sammelr?hre schreitet immer weiter fort, so dass man beim 13.5mm langen Embryo von 16 Tagen schon quint?re Sammelr?hre erkennen kann. In diesem Entwicklungsstadium verbinden sich auch die Sammelr?hre an ihren Endteilen mit Harnkan?lchen, wodurch die Kommunikation zwischen den Sammelr?hren und Harnkan?lchen ganz vollendet wird. 7) Die Verzweigung der Sammelr?hre tritt immer regelm?ssig dichotomisch auf, und es l?sst sich bei ihr gew?hnlich im rechten Nierenbecken ein st?rkerer Fortschritt beobachten. 8) Das metanephrogenen Gewebe bildet sich zuerst beim etwa 5.5mm langen, 43 Ursegmente besitzenden Embryo, 11.5 Tage nach der Begattung, von der caudalen Partie des nephrogenen Gewebes aus. 9) Beim 6.5mm langen, 48 Uresegmente zeigenden Embryo von 12 Tagen teilt sich das metanephrogene Gewebe in zwei Zonen, in eine dichte Innenzone und eine lockere Aussenzone. Die erstere umgibt das Nierenbecken als Epithelialmantel, die letztere umh?llt die erstere noch von aussen und erstreckt sich in der Form eines Zellstranges kranialw?rts. Aber beim 4.0mm langen Embryo von 13 Tagen ist dieser Zellstrang schon nicht meter wahrnehmbar; so verschwindet die Aussenzone sofort, nachdem sie die Innenzone umh?llt hat, ohne sich nach oben zu erstrecken. 10) In der Zeit, wo die prim?re Sammelr?hre vom Nierenbecken herauswachsen, sind ihre Endst?cke von der Innenzone des metanephrogenen Gewebes umgeben, zentralw?rts aber verlieren sie these H?lle, wesbalb die zentralen Teile der Sammelr?hre und der Stammteil des Nierenbeckens direkt von der Aussenzone umh?llt sind. 11) Beim etwa 13.0mm langen Embryo von 15 Tagen bildet die Innenzone des metanephrogenen Gewebes, die butf?rmig die Spitze der Sammelr?hre umh?llt, die Zellkugeln, ferner die Zellbl?schen, die Anlagen der Harnkau?lchen in ihrem zentralw?rts umgekebrten Ende. 12) Beim etwa 13.5mm langen Embryo von 16 Tagen kommen endlich die Harnkan?lchen, die sich zuerst hakenf?rmig und dann weiter S-f?rmig umbilden, in Verbindung mit den Endstucken der Sammelr?hre.13) Diese Verbindung geht immer an den terti?ren bis quint?ren Sammelr?hren vor sich, die prim?ren und sekund?ren Sammelr?hre beteiligen sich nicht daran. 14) Von disen Verbindungen zwischen den Sammelr?hren und Harnkan?lchen kann ich beim etwa 13.5mm langen Embryo von 16 Tagen in der linken Nierenanlage 33, und in der rechten 31 z?hlen. 15) W?hrend der Entwicklung ver?ndert die Nierenanlage ihre Lage von caudal nach kranial, inzwischen f?hrt sie auch eine zweifache Ver?nderung der Achsenrichtung "(1) eine nach der Mit telebene, und (2) eine nach der Horizontalebene gerichtete Achsenver?nderung" und eine zweifache Rotation "(1) eine dorso-laterale Rotation mit der L?ngsachse und (2) eine kranio-ventrale Rotation wit der Queracbse" aus. 16) Die Differenz zwischen der Lage der linken und der rechten Nierenanlage wird zuerst beim 13.0mm langen Embryo von 15 Tagen sichtbar, bei welchem das rechte Nierenbecken 60μ h?her kranial w?rts liegt als das links. Diese Differenz betr?gt beim 13.5mm langen Embryo von 16 Tagen schon 0.13mm. en-copyright= kn-copyright= en-aut-name=OfujiToshiharu en-aut-sei=Ofuji en-aut-mei=Toshiharu kn-aut-name=大藤利治 kn-aut-sei=大藤 kn-aut-mei=利治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學解剖學教室胎生學研究室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=565 end-page=574 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on Hypersplenism Part 1 Experimental Splenic Anemia by Abdominal Sympathectomy of Splenic Branches kn-title=脾機能亢進症に関する実験的研究 第1編 腹部交感神経脾臓枝切断による実験的脾性貧血に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=After the abdominal sympathectomy of splenic branches in nomal rabbits, the auther studied the blood and bone marrow pictures and iron metaborism, and obtained the following results. 1) In the peripheral blood picture a transient decrease in the erythrocyte count, hemoglobin content and platelet count could be observed. 2) In the bone marrow picture an increase and inhibition of maturation in the erythroid system could be observed. 3) Serum iron decreased conspicuously. However, the depot iron was as usual or increased a little. 4) In the bone marrow picture a little decrease in Sideroblast could be observed. 5) In the serum and spleen extracts, the existence of anemia producing toxic factor could not be observed. 6) From these observation, the author concluded that the principal cause of this anemia produced by ligating splenic and coronary Veins of the stomach lay in the inhibition on the mobilization of depot iron. en-copyright= kn-copyright= en-aut-name=TsuyunoYoshihiko en-aut-sei=Tsuyuno en-aut-mei=Yoshihiko kn-aut-name=露野嘉彦 kn-aut-sei=露野 kn-aut-mei=嘉彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=961 end-page=991 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Serologische Studien ?ber mit Formalin Vorbehandelte rote Blutk?rperchen und Serum (I. Mitteilung.) ?ber den Einfluss von Formalin anf die Blutk?rperchenresistenz kn-title=血球竝ニ血清ニ及ボス「フオルマリン」ノ影響ニ就テ(第1報)赤血球ノ抵抗ニ及ボス「フオルマリン」ノ影響ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verfasser untersuchte zuerst die Resistenz der roten Blutk?rperchen gegen hypo- und hypertonische Salzl?sung. S?ure, Alkali, Normal- und Immunh?molysine, und zwar die von normalen und mit Formalin vorbehandelten roten Blutk?rperchen von Kaninchen, Meerschweinchen, Ziegen, Hunden, Schweinen, Rindern und H?hnern, sodann pr?fte er in der gleichen Weise die roten Blutk?rperchen nach der Milz-exstirpation. 1) Bei den roten Blutk?rperchen h?ngt die Ver?nderung der Resistenz gegen hypotonische Kochsalzl?sung von der Konzentration des zugesezten Formalin ab, weil die vorbehandelten Roten bei schwacher L?sung stark labiler, dagegen bei hoch konzentrierter L?sung viel resistenter geworden sind. 2) Es ist bemerkenswert, dass die Formalin-konzentration bei zirca 0.4% am st?rksten auf die roten Blutk?rperchen einwirkt. 3) Die roten Blutk?rperchen von verschiedenen Tierarten zeigen eigent?mliche Resistenzen gegen hypotonische Kochsalzl?sung. Sie stehen dabei in der Reihenfolge: H?hner, Meerschweinchen, Kaninchen, Hunde, Schweine, Rinder und Ziegen. Bez?glich der Formalin-Wirkung auf verschiedene rote Blutk?rperchen besteht dieselbe Reihenfolge wie bei hypotonischer Salzl?sung, n?mlich: H?hner, Meerschweinchen, Kaninchen, Hunde, Schweine, Rinder und Ziegen. 4) Formol-fixierte rote Blutk?rperchen zeigen geringere Resistenz gegen S?ure und Alkali als normale unbehandelte rote Blutk?rperchen. 5) Formol-fixierte rote Blutk?rperchen werden auch viel labiler gegen Immun-h?molysin, Normal-h?molysin und die Komplementwirkung. 6) Nach der Milz-exstirpation werden die roten Blutk?rperchen von operierten Tieren (bei Kaninchen und Ziege) resistenter gegen hypotonische Salzl?sung, S?ure, Alkali und H?molysinwirkung. Diese gesteigerte Resistenz wird jedoch durch Formalin-l?sung mehr oder weniger beeinflusst. en-copyright= kn-copyright= en-aut-name=KoizumiMichinori en-aut-sei=Koizumi en-aut-mei=Michinori kn-aut-name=小泉道徳 kn-aut-sei=小泉 kn-aut-mei=道徳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學衛生學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=992 end-page=1012 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Anatomical and Histological Observations of the Heart of Tachypleus tridentatus kn-title=日本産「カブトガニ」Tachypleus tridentatusノ心臟ノ解剖學的竝ニ組織學的觀察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The anatomy and histology of the heart of Limulus Polyphemus have been described by Patten and Redenbaugh, Milne-Edwards and Walter Meek, but they are not in complete agreement. In the case of Branchio cardiac canal, for instance, Milne-Edwards reported six pairs of veins but Patten and Redenbaugh five pairs. There is little recorded work on the anatomy and histology of the heart of Tachypleus tridentatus in Japan, and although Dr. Nukada and Dr. Hoshino made brief anatomical and histological description for the purpose of Physiological study, they also disagree on some points. The former maintains and the later denies the presence of Volhof and Spezifische Muskelfasern. On account of these discrepancies, I made certain studies in comparison with previous results and some researches into new ground. Most of the materials were fixed in formalin and after subsequent treatment in the usual manner, the specimens were embedded in paraffin, trimmed and cut in transverse serial sections and longitudinal sections with thicknesses of 5.0, 25.0, and 50.0 microns. The sections were stained with Eosin-H?matoxylin and Nissl's method was used. A model was prepared according to Born-Peter's method of wax-plate reconstruction. From the results of my experiments, the following summary and conclusions were made: 1) The heart of Tachypleus tridentatus is a long tubular organ consisting of one ventricle, situated longitudinally on the lower part of median line of the carapace. It lies in a large pericardial sinus and is pupported by three holding tissues, Ligamentum suspensoria cordis superior, Alary muscle, and Veno-pericardiac muscle. 2) Around the heart is a large pericardial sinus, enclosed by a pericardium. Pericardium is a thin menbrane consisting of connective tissue fibres. There are eight pairs of Ostia on the dorsal wall of the heart, and they are the doors by which the blood in the pericardial sinus enters the heart. 3) There are eleven arteries leading off from the heart; one pair of Aortic arches and Arteria frontalis from the frontal end of the heart, and four pairs of Arteriae laterales arise from the lateral wall of the heart. Each artery has a valve. The aortic valve, much like a vertebrate Semilunar valve, lies upon the dorsal wall of the heart at the base of the Aortic arches. The Arteriae laterales are supplied with paired Semilunar valves at their points of origin from the heart. Each valve consists of connective tissues. 4) Pericardial sinus has veins, namely Branchio cardiac canal. I found five pairs of Branchio cardiac canal. I could not recognize six-pairs as described by Milne-Edwards. 5) The structure of the cardiac walls is composed of three layers. The outer most layer consists of the longitudinal elastic conective tissue fibres. The middle layer is the Basement membrane consisting of annular connective tissue fibres. The inner most layer is the circular muscular layer consisting of cross-striated muscular fibres. No membrane limiting the lumen, corresponding to the Endocardium of the mamalian heart is present. The cross-striated muscular fibres of Tachypleus tridentatus, resemble the mammalian heart, branching and anastomosing with each other, so form a syncytium. Also the individual muscular fibres are much like those of nammals, having nuclei surrounded by sarcoplasm and the fibrils make numerous bundles or Cohnheim's field. I think that the muscular fibres have no sarcolemma. 6) The author could not recognize the existence of Volhof and Spezifische Muskelfasern which were Dr. Nukada. 7) An median Cardiac nerve and one pair of Lateral cardiac nerves lie longitudinally on the heart. The branches of these two kinds of cardiac nerves anastomosing with each other, thus make the Cardiac nerve plexus. Median Cardiac nerve communicates with the centre by the Segmental cardiac nerve, Haemal nerve and Ventral cord. The structure of the nerve fibre consists of neurolemma and axis cylinder. There is no medullary sheath. The median cardiac nerve fibers possess the ganglion cells. en-copyright= kn-copyright= en-aut-name=KochiTakeshi en-aut-sei=Kochi en-aut-mei=Takeshi kn-aut-name=河内武 kn-aut-sei=河内 kn-aut-mei=武 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學解剖學教室胎生學研究室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=1013 end-page=1042 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Serologische Studien ?ber die Serumlipoide. (I. Mitteilung.) kn-title=血清類脂體ノ免疫學的研究(第1報)血清類脂體免疫ニヨル抗體ノ生産ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HirotaTeruki en-aut-sei=Hirota en-aut-mei=Teruki kn-aut-name=廣田照輝 kn-aut-sei=廣田 kn-aut-mei=照輝 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學衛生學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=999 end-page=1004 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical Effect of Yakult (Cow's Milk Fermented by Some Sort of “Family Lactbacillaceae” Commonly Sold as a Soft Drink) Part I. Fluctuation of pH. of the Stool After Drinking Yakult kn-title=乳酸菌ヤクルトの臨床効果に就て(第二報)(抗結核化学療養患者に於ける変化) 其の一 市販ヤクルト飲用による糞便pHの変化 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the purpose to determine the fluctuation of pH. of the stool after drinking "Yakult", cow's milk fermented by some sort of "Family Lactbacillaceae", the authors made normal adults and patients with lung tuberculosis drinking one bottle (60 cc) a day of Yakult successively, and estimated the pH. of their stool colorimetrically and obtained following results. 1. In the case of normal adults taking a bottle (60 cc) of Yakult a day successively, no marked fluctuation can be recognized. 2. In the case of patients with lung tuberculosis receiving drug treatment (chemotherapy) pH. range was 6.0~7.0 namely marked difference from normal adults can be recognized. 3. In the case of patients with lung tuberculosis receiving chemotherapy, after drinking Yakult, pH. of their stool become equal with that of normal adults'. By drinking Yakult marked effect was recognized. en-copyright= kn-copyright= en-aut-name=NanbaHisao en-aut-sei=Nanba en-aut-mei=Hisao kn-aut-name=難波寿夫 kn-aut-sei=難波 kn-aut-mei=寿夫 aut-affil-num=1 ORCID= en-aut-name=OonisiHiroyuki en-aut-sei=Oonisi en-aut-mei=Hiroyuki kn-aut-name=大西弘之 kn-aut-sei=大西 kn-aut-mei=弘之 aut-affil-num=2 ORCID= en-aut-name=TanakaYosio en-aut-sei=Tanaka en-aut-mei=Yosio kn-aut-name=田中義夫 kn-aut-sei=田中 kn-aut-mei=義夫 aut-affil-num=3 ORCID= en-aut-name=MikiHukuziro en-aut-sei=Miki en-aut-mei=Hukuziro kn-aut-name=三木福治郎 kn-aut-sei=三木 kn-aut-mei=福治郎 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=医療法人謳生会病院 affil-num=2 en-affil= kn-affil=医療法人謳生会病院 affil-num=3 en-affil= kn-affil=医療法人謳生会病院 affil-num=4 en-affil= kn-affil=医療法人謳生会病院 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=575 end-page=581 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on Hypersplenism Part 2 Experimental Splenic Anemia by Ligating Splenic Veins and Coronary Veins of the Stomach kn-title=脾機能亢進症に関する実験的研究 第2編 脾静脈及び胃冠状静脈結紮による実験的脾性貧血に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=After ligating splenic and coronary veins of the Stomach in normal rabbits, the author studied the blood and bone marrow pictures and iron metaborism, and obtained the following results. 1) In the peripral blood picture a transient little decrease in the erythrocyte count, hemoglobin content and platelet count could be observed. 2) In the bone marrow picture an increase and inhibition of mataration in the erythroid system could be observed. 3) Serum iron decreased conspicuously. However, the depot iron increased a little. 4) In the bone marrow picture a decrease of Sideroblast could be observed. 5) In the serum and spleen extracts, the existence of anemia producing toxic factor could be recognized. 6) From these observation, the author concluded that the principal cause of this anemia produced by the abdominal sympathectomy of splenic branches lay in the inhibition of maturation of the erythroblast as result of the inhibitory action of the toxic factor on the mobilization of depot iron. en-copyright= kn-copyright= en-aut-name=TsuyunoYoshihiko en-aut-sei=Tsuyuno en-aut-mei=Yoshihiko kn-aut-name=露野嘉彦 kn-aut-sei=露野 kn-aut-mei=嘉彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=1043 end-page=1057 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimentelle Untersuchung ?ber die Farbenreaktion und die Jodmetrie von oxydierbaren Substanzen (I. Mitteilung.) Bestimmung der oxydierbaren Substanzen mittels Farbenreaktion und Jodmetrie kn-title=動植物組織内ニ於ケル被酸化物質ニ就テ(第1報)被酸化物質ノ呈色反應ヨード法ニヨル測定 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verfasser mass die Reduktionsf?higkeit der oxydierbaren Substanzen von tierischen und pflanzlichen Geweben mittels Farbenreaktion und Jodmetrie, im Verein mit einigen Studien ?ber ihre Physikalisch-chemischen Eigenschaften. 1) Die Farbenreaktion und die Jodmetrie vom Wasserextrakt und Pressaft zeigen in den meisten F?llen einen parallelen Zusammenhang, aber ihr Reaktionsgrad ist je nach der Art des untersuchten Materials verschieden. 2) Die oxydierbaren Substanzen gehen in Alkohol, Aceton und die L?sung einer Cyanverbindung ?ber, aber nicht in Ether. Sie werden von basischem Bleiacetat gef?llt, nicht aber von neutralem Bleiacetat oder von Phosphorwolframs?ure. 3) Diese oxydierbaren Substanzen sind sehr labil gegen Sonnenlicht, Wasserstoffsuperoxyd. Ihr Widerstand gegen W?rme ist verschieden, und zwar ist diejenige Substanz, die die beiden Farben- und Jodreaktionen deutlich zeigt, thermostabil. 4) Der Glutathionengehalt ist im pflanzlichen Gewebe geringer als im tierischen, und der Jodverbrauch der Glutathione ist geringer als derjenige der die Glutathione enthaltenden oxydierbaren Substanzen. 5) Der Wasserextrakt aus den Wurzeln der Lotuspflanze, Kiefernadeln, Orang- oder Eichenbl?ttern zeigt Zuckerreaktionen; daraus kann man eine Art von Osazon darstellen, dessen Schmelzpunkt zwischen 204° und 208°C liegt. 6) Die oxydierbaren Substanzen werden von Tierkohle adsorbiert, aber nicht von Bolus alba. Sie k?nnen Filtrierpapier, kollodiummembran, Fischskin und Pergamentpapier durchpassieren. 7) Die Rindensubstanz der gesunden Nebenniere hat die F?higkeit, Silber stark zu reduzieren. en-copyright= kn-copyright= en-aut-name=KonisiM. en-aut-sei=Konisi en-aut-mei=M. kn-aut-name=小西眞尚 kn-aut-sei=小西 kn-aut-mei=眞尚 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學生理學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1005 end-page=1009 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical Effect of Yakult (Cow's Milk Fermented by Some Sort of “Family Lactbacillaceae” Commonly Sold as a Soft Drink) Part II. Fluctuation of Vitamin B(1) in the Urine After Drinking Yakult kn-title=乳酸菌ヤクルトの臨床効果に就て(第二報)(抗結核化学療養患者に於ける変化) 其の二 市販ヤクルト飲用による尿中ビタミンB1の消長 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to determine the fluctuation of vitamin B(1) in the urine after drinking "Yakult", cow's milk fermented by some sort of "Family Lactbacillaceae", the authors made normal adults and patients with lung tuberculosis drink one bottle (60 cc) a day of Yakult successively, and estimated their content of vitamin B(1) in their urine polarographically and with paper chromatography. Results are as follows. 1. In the case of one bottle (60 cc) of Yakult successively, there occurs a little increment of vitamin B(1) content in their urine of normal adults comparing with tuberculous patients receiving chemotherapy. 2. In the case of taking one bottle of Yakult, no marked effect can be recognized in their urine of tuberculous patients receiving chemotherapy. However, when three bottles (180 cc) of Yakult are given every day, marked increase of vitamin B(1) can be observed even in their urine of the patients, and also impeding factor in polarographical estimation disappears, proving that Yakult is considerably effective in improving vitamin B(1) metabolism. en-copyright= kn-copyright= en-aut-name=NanbaHisao en-aut-sei=Nanba en-aut-mei=Hisao kn-aut-name=難波寿夫 kn-aut-sei=難波 kn-aut-mei=寿夫 aut-affil-num=1 ORCID= en-aut-name=OonisiHiroyuki en-aut-sei=Oonisi en-aut-mei=Hiroyuki kn-aut-name=大西弘之 kn-aut-sei=大西 kn-aut-mei=弘之 aut-affil-num=2 ORCID= en-aut-name=AritiSigeru en-aut-sei=Ariti en-aut-mei=Sigeru kn-aut-name=有地茲 kn-aut-sei=有地 kn-aut-mei=茲 aut-affil-num=3 ORCID= en-aut-name=MikiHukuziro en-aut-sei=Miki en-aut-mei=Hukuziro kn-aut-name=三木福治郎 kn-aut-sei=三木 kn-aut-mei=福治郎 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山県乳酸菌ヤクルト臨床研究所 affil-num=2 en-affil= kn-affil=岡山県乳酸菌ヤクルト臨床研究所 affil-num=3 en-affil= kn-affil=岡山県乳酸菌ヤクルト臨床研究所 affil-num=4 en-affil= kn-affil=岡山県乳酸菌ヤクルト臨床研究所 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=1058 end-page=1062 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber ein Distomum aus dem Darm von Megalobatrachus japonicus kn-title=大山椒魚ノ腸管ニ寄生スルLiolope copulansニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Liolope copulans, eine Art von Trematoden, wurde 1897 von G. W. M?ller im Verdauungstraktus von Megalobatrachus japonicus gefunden und wurde von L. Cohn beschrieben. Wir fanden auch dasselbe Spezimen in grosser Anzahl im Darm einiger Megalobatrachus japonicus aus Provinz Okayama. Unsere Beobachtungen weichen aber in einigen Punkten von der Cohnschen wesentlich ab. Wir fassen unsere Resultate kurz zusammen wie folgt: 1) Die Gr?sse des K?rpers misst durchschnittlich 1.8mm. (1.52-2.28mm) 1. und durchschnittlich 0.97mm. (0.72-1.06mm.) br.; unserer Wert ist etwas gr?sser als der Cohnsche, welcher 1.5mm 1. und 0.75mm br. betr?gt. 2) Cohn beschreibt f?lschlich, dass “ein Oesophagus fehlt.” Nach unserer Beobachtung ist der Oesophagus ganz kurz; betr?gt ca. 0.014mm. 3) Der Exkretionsporus liegt dorsalw?rts kurz vor dem Hinterende des K?rpers. Die Exkretoinsblase ist ein ganz merkw?rdiges Gebilde wegen ihrer Besoderheit des Baues. Der Endteil der Exkretionsblase, welcher direkt mit dem Exkretionsporus verbindet, teilt sich bald in zwei Schenkeln, rechts und links. Jeder Schenkel teilt sich wieder in zwei Schenkeln. Diese vier Schenkeln verlaufen fast parallel nach vorn entlang jedes Darmschenkels. Je zwei Schenkeln in jeder Seite anastomosiert sich kurz hinter dem Mundsaugnapf wieder und bildet je einen geschlossenen Ring in jeder Seite. Ein Sammelkanal m?ndet sich etwas r?ckw?rts im vorderen Zipfel jeder Exkretionsblase ein. Dieser Befund widerspricht sich allerdings von dem Cohnschen ab. 4) Die dickschaligen Eier mit einem Deckel sind charakteristischer Weise Nierenform. Sie messen durchschnittlich 0.138mm 1. und durchschnittlich 0.068mm br. en-copyright= kn-copyright= en-aut-name=KagawaSakae en-aut-sei=Kagawa en-aut-mei=Sakae kn-aut-name=香川榮 kn-aut-sei=香川 kn-aut-mei=榮 aut-affil-num=1 ORCID= en-aut-name=KuyamaShosaku en-aut-sei=Kuyama en-aut-mei=Shosaku kn-aut-name=久山正策 kn-aut-sei=久山 kn-aut-mei=正策 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學細菌學教室 affil-num=2 en-affil= kn-affil=岡山醫科大學細菌學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=1063 end-page=1068 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On Action of Electricity upon Organisms (2nd. Report.) Haemolysis by Electric Current kn-title=電流ノ生物ニ對スル作用ニ就テ(第2報)電流ニヨル溶血現象ニ關スル研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author studied on the haemolytic action of the electric current upon the red blood corpuscles of rabbits, suspended in the 0.9% NaCl solution. He confirmed the following facts. 1) Red blood corpuscles were haemolysed only by the constant current, but never by the alternating current, if the alternation is sufficiently frequent. 2) In regard to the relationship between the strength of the electric current and its duration holds good the Weiss-Hoorweg's formula for the excitation of muscle and nerve. 3) It is highly probable that the alkalinity, which has been produced in the neighbourhood of the negative Pole, plays the important r?le on the electrical haemolysis. en-copyright= kn-copyright= en-aut-name=MoriNobutane en-aut-sei=Mori en-aut-mei=Nobutane kn-aut-name=森信胤 kn-aut-sei=森 kn-aut-mei=信胤 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學生理學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=1069 end-page=1093 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Action of Electric Current upon Organisms (3rd. Report.) On the Alternation of Permeability of Cell-membranes by Electric Current kn-title=電流ノ生物ニ對スル作用ニ就テ(第3報)電流刺戟ニヨル細胞膜ノ透過性ノ變化ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The auther studied on alternation of permeability of cell-membranes by electric current and reached to the following results. 1) Plasmolysis of epithelial cells of Tradescantia virginica by hypertonic solution (0.5-1.0%) of sodium chloride will be stopped at the neighbourhood of the cathode by passing through of the electric current. 2) In the neighbourhood of cathode potassium-ions escape from the cells into the surrounding medium. It will be so understanded that the damage of semipermeability of the cell-membranes allows passage of anion and potassium-ion escapes in balance of it. Same thing occurs on the muscle cutaneus dorsi of frog. 3) Potassium-escape can be observed on the resting muscle of frog when the temperature of bathing fluid exceeds 29-32°C. en-copyright= kn-copyright= en-aut-name=MoriNobutane en-aut-sei=Mori en-aut-mei=Nobutane kn-aut-name=森信胤 kn-aut-sei=森 kn-aut-mei=信胤 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學生理學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=1094 end-page=1108 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber den Zucker-, Fettstoffwechsel und die passive Anapbylaxie bei experimenteller Kaninchenclonorchiasis sinensis (2. Mitteilung.) Experimentelle Untersuchung ?ber den Fettstoffwechsel bei der Kaninchenclonorchiasis kn-title=實驗的肝臟「ヂストマ」病家兎ニ於ケル糖代謝,脂肪代謝竝ニ被働性過敏症ニ就テ 第2報 脂肪代謝ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verfasser, der den Zuckerstoffwechsel bei der experimentellen Kaninchenclonorchiasis untersucht hatte (diese Zeitschrift Nr. 542, 1935.), studierte diesmal den Fettstoffwechsel bei Kaninchenclonorchiasis. Er stellte Tributyrinspaltungsversuche mit dem Leberbrei aus kranken und normalen Kaninchen an und weiter ebensolche Versuche mit Glyzerinauszug des Pankreaspulvers vom Rinde unter Zusatz von Leberextrakt aus normalen oder kranken Kaninchen. Die Resultate der Versuche sind folgende: 1) Die tributyrinspaltende Wirkung des Leberbreies von kranken Kaninchen wurde bei pH 8.043 und 38°C stark gebemmt. 2) Die Wirkung der Rinderpankreaslipase wurde durch Zusatz von Leberextrakt aus kranken Kaninchen auch hemmend beeinflusst, w?hrend bei Zusatz von Leberextrakt aus normalen Kaninchen fast kein Einfluss bemerkbar war. 3) Nach den obigen Versuchsresultaten nimmt Verfasser an, dass der Fettstoffwechsel bei Kaninchenclonorchiasis wesentlich gest?rt werden m?sste. en-copyright= kn-copyright= en-aut-name=UyenoHiroshi en-aut-sei=Uyeno en-aut-mei=Hiroshi kn-aut-name=上野博 kn-aut-sei=上野 kn-aut-mei=博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學法醫學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=1109 end-page=1118 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=尿道淋疾竝ニ其ノ合併症ニ對スル「ゴノブロカノン」ノ應用 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=山本春海 kn-aut-sei=山本 kn-aut-mei=春海 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學皮膚科泌尿器科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=1119 end-page=1122 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=雜報 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山医学会 kn-aut-sei=岡山医学会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1143 end-page=1159 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber die Beeinflussung der Senkungsgeschwindigkeit und der Resistenz der Erythrozyten durch perorale Darreichung von Brennpetroleum bei Kaninchen kn-title=石油ヲ投與セラレタル家兎ノ赤血球沈降反應及ビ血球抵抗 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bei der peroralen Darreichung des Bernpetroleums bei Kaninchen, und zwar 1cc pro Kilo, wurden keine toxischen Erscheinungen wie Appetitlosigkeit, Diarrhoe u. s. w. klinisch nachgewiesen, die Senkungsgeschwindigkeit der roten Blutk?rperchen erh?hte sich jedoch 6 bis 9 Tage nach der Darreichung und die Resistenz derselben gegen hypotonische Kosalzl?sung verminderte sich ziemlich. Als einen wesentlichen Faktor f?r diese Ver?nderung der Erythrozyten k?nnte man Cholesterin?mie nach Brennpetroleumzufuhr, die Hiromoto in dem oben genannten Institut zuerst bemerkt hatte (noch nicht publiziert), ansehen. Weiter best?tigte Verfasser, dass die unscharfen Zone fast regelm?ssig bei der Bestimmung der Senkungsgeschwindigkeit auftrat, was auf die Vermehrung der jungen Erythrozyten zur?ckzuf?hren ist. Diese 3 Erscheinungen des Blutes verloren sich allm?hlich wieder im Verlaufe von 6 bis 9 Tagen nach der Darreichung des Brennpetroleums. en-copyright= kn-copyright= en-aut-name=MomonoiKwanji en-aut-sei=Momonoi en-aut-mei=Kwanji kn-aut-name=桃井寛次 kn-aut-sei=桃井 kn-aut-mei=寛次 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學法醫學教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=4-6 article-no= start-page=583 end-page=589 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on Hypersplenism Part 3 The Effects of Splenic Toxic Factor on White Cell Series kn-title=脾機能亢進症に関する実験的研究 第3編 実験的貧血家兎脾毒性因子の白血球系に及ぼす影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=By the simple method of bone marrow tissue culture, the author studied on the effects on white blood cells of bone marrow by adding serum and spleen extracts of the rabbits with experimental splenic anemia, and obtained the following results. 1) In the group of rabbits with the abdominal sympathectomy of splenic branches, a little inhibition of tissue growth and a little decrease of the wandering velocity of pseudoeosinophils could be observed. 2) In the other group, both tissue growth and wandering velocity formed a contrast, and the specially efficient difference could not be observed. 3) From these observation, the author observed that the splenic toxic factor produced in the experimental anemic rabbits acted directly upon the bone marrow, and caused a increase in the leucocyte and the inhibition of the motor function. en-copyright= kn-copyright= en-aut-name=TsuyunoYoshihiko en-aut-sei=Tsuyuno en-aut-mei=Yoshihiko kn-aut-name=露野嘉彦 kn-aut-sei=露野 kn-aut-mei=嘉彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1011 end-page=1022 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Gastric Ulcer Induced by Hormonal Disharmony Part 1. On the Influence of Some Changes in Blood Component Upon the Gastric Ulcer Induced by Adrenalectomy kn-title=ホルモン失調性胃潰瘍の実験的研究 第1編 ホルモン失調性胃潰瘍と血液性変化との関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The relationship between the ulceration in the glandular stomach of rats, induced by adranalectomy, and the substitution therapy or the changes in blood components has been investigated. As agents for the substitution therapy after adranalectomy physiologic saline solution, cortisone and DOCA were used. During the substitution therapy, non-protein nitrogen in whole blood, protein and sodium-potagsium concentration in serum were determined. When the abnormality of sodium-potassium balance in the serum after adrenalectomy was corrected by the administration of physiologic saline solution or cortisone (0.1-0.15/mg/day/100g B.W.), ulceration could be prevented. However, when the excessive substitution therapy by cortisone (5 mg/bay/animal) was done, it was failed to prevent the induction of ulceration. When DOCA was used excessively and sodium-potassium balance in serum was under the state of disharmony, no ulceration was found. And it was recognized that the ulceration and the change in the none protein nitrogen or protein was not intimately correlated. Through these experiments, it has been, therefore, surmized that the gastric ulceration following adranalectomy was mainly influenced by the sort of substitution therapy, rather than by the alteration of certain specific factor in the blood components. en-copyright= kn-copyright= en-aut-name=KondoHidemi en-aut-sei=Kondo en-aut-mei=Hidemi kn-aut-name=近藤日出海 kn-aut-sei=近藤 kn-aut-mei=日出海 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=591 end-page=616 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Anticancer Chemotherapy Especially on the effect of anticancer agents and anticancer supporting substances on the metabolism of cancer bearing mice PART T The effect of anticancer agents and anticancer supporting substances on the hosts of malignant tumor and its correlation with enzyme metabolism kn-title=癌の化学療法に関する研究 特に制癌剤並びに制癌強化剤の担癌生体内代謝に及ぼす影響に就いて 第1編 制癌剤および制癌強化剤の抗腫瘍性効果,並びに担癌生体酵素代謝に及ぼす影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=In is known that cancer research has been concentrated to make a correlation between cancer and its bearing hosts. An attempt was made to study anticancer effect and enzyme metabolism under the administration of anticancer agents and their supporting substances in order to destruct cancer cells and increase biological resistance of its bearing mice. The results obtained are as follows: 1) Marked prolongation in survival period and inhibition of ascites were obtained in cancer bearing mice under mitomycin administration, but the administration of its large dosage in contrast, inhibited a prolongation of survival period and also made a loss of body weight. The combined administration of anticancer agents and their supporting substances manifested the most remarkable prolongation in survival period. Amongst three anticancer supporting substances, orotic acid made the greatest prolongation of survival period as well as marked inhibition of ascites. Glucuronic acid made the same results in less degree. 2) Mitomycin had a marked effect to inhibit the depression of catalase activity in liver and kidney of cancer bearing group, although mitomycin itself had a tendency to decrease catalase activity in liver and kidney of normal group. 3) Anticancer supporting substances, orotic acid and glucuronic acid markedly increased catalase of liver in normal group and inhibited the tendency of its decrement in cancer bearing group. 4) Anticancer agents showed the same tendency to saccinic dehydrogenase activity as to catalase. 5) S-GOT and S-GPT slightly increased in cancer bearing group. They were intensively improved under the combined administration of anticancer agents and their supporting substances. en-copyright= kn-copyright= en-aut-name=MatsuuraUmeharu en-aut-sei=Matsuura en-aut-mei=Umeharu kn-aut-name=松浦梅春 kn-aut-sei=松浦 kn-aut-mei=梅春 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1023 end-page=1030 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Gastric Ulcer Induced by Hormonal Disharmony Part 2. On the Influence of Some Chemical Components Changes in the Gastric Wall Upon the Gastric Ulcer Induced by Adrenalectomy kn-title=ホルモン失調性胃潰瘍の実験的研究 第2編 ホルモン失調性胃潰瘍と組織水分及び塩類代謝との関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this part, the changes in the concentration of water, sodium and potassium in the wall of the fore-stomach, glandular stomach, intestine and muscle of the rat, treated in the same manner as stated in the Part 1, were determined. And the relationship between these changes and the ulceration of the glandular stomach was studied. Water content in the every tissue of the rat, in either non-treated or treated by physiologic saline solution after adrenalectomy, was increased, but not in the rat treated by the other agents. And it was recognized that the ulceration and the change of water content in the gastric wall were not intimately corelated. The changes of sodium and potassium contents in these digestive organ were not identiccal, and no regulation was observed there. And it was recognizes that the ulceration and the change of sodium and potassium content in the gastric wall after adrenalectomy were not intimately corelated. en-copyright= kn-copyright= en-aut-name=KondoHidemi en-aut-sei=Kondo en-aut-mei=Hidemi kn-aut-name=近藤日出海 kn-aut-sei=近藤 kn-aut-mei=日出海 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1031 end-page=1043 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Disorders in Vascular Factor and its Prevention in Reference to Hemorrhagic Tendency Following Massive Transfuions of Preserved Blood Part I: Studies on the Mechanism of Disorders in Vascular Factor kn-title=保存血大量輸血に伴う血管因子障害とその対策 前編 成因に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=About on hemorrhagic tendency following massive transfusions of preserved blood, dynamics of mesenteric capillaries, changes in capillary resistance and platelets, and bleeding time were studied experimentally and clinically. Following transfusions, peripheral capillaries were dilated and the blood stream become slow and pooling. Endothelial damages, increase in the permeability and escaping of red blood cell through the wall were observed. Capillary resistance was decreased in the early stage of transfusions and was closely related to the injected blood volume. Striking decrease in number of platelets and prolongation of bleeding time were also recognized in almost all of the cases. It was surmizd that the main factor of hemorrhagic tendency was increase in the permeability or the fragility predisposed by changes in capillary wall with reduction in platelet counts due to blood transfusion itself. en-copyright= kn-copyright= en-aut-name=HiraoYoshishige en-aut-sei=Hirao en-aut-mei=Yoshishige kn-aut-name=平尾喜茂 kn-aut-sei=平尾 kn-aut-mei=喜茂 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1045 end-page=1059 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Disorders in Vascular Factor and its Prevention in Reference to Hemorrhagic Tendency Following Massive Transfusions of Preserved Blood Part U: Studies on the Prophylaxis and Therapy of Vascular Disorders kn-title=保存血大量輸血に伴う血管因子障害とその対策 後編 治療に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Concerning the vascular disorders caused by massive transfusions of preserved blood, the influence of several treatments on the vascular system was estimated by the capillary resistance, hyaluronidase diffusion ratio, platelet count and bleeding time. There was a striking effect on the improvement of the vascular disorders as continuous injection of intravenous hydrocortisone. Fresh blood and platelet transfusions improved the vascular impairments, same as in adrenochrome. And an effectiveness was observe, even in alternated transfusion of the fresh and the presrved blood. ε-Aminocapronic acid was useful for the correction of vascular disorder due to fibrinolysis. Moreover thromboplastin preparations, such as Manetol, and Naphthionic acid were also effective. It was proposed that those measures described above should be performed as prophylaxis before or during blood transfusions, rather than as a therapeutics after transfusions. en-copyright= kn-copyright= en-aut-name=HiraoYoshishige en-aut-sei=Hirao en-aut-mei=Yoshishige kn-aut-name=平尾喜茂 kn-aut-sei=平尾 kn-aut-mei=喜茂 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=617 end-page=632 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Anticancer Chemotherapy Especially on the effect of anticancer agents and anticancer supporting substances on the metabolism of cancer bearing mice PART U The effect of anticancer agents and their supporting substances on nucleic acid metabolism of malignant tumor and on cancer cell proliferation kn-title=癌の化学療法に関する研究 特に制癌剤並びに制癌強化剤の担癌生体内代謝に及ぼす影響について 第2編 制癌剤および制癌強化剤の担癌生体核酸代謝に及ぼす影響,並びに癌細胞分裂像との相関に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Nucleic acid metabolism of tumor itself and liver in cancer bearing mice, DNA matabolism of intraperitoneal free cancer cells were measured by microspectrophotometer (MSP) and their correlation with cancer cell proliferation were analyzed under administrations of anticancer agents and their supporting substances. The results obtained are as follows: 1) The ratio of RNA to DNA is approximately 2.6 in liver of normal mice. DNA was considerably increased in cancer bearing group, and was about 2.5 times greater than that of normal group. 2) Mitomycin inhibited DNA metabolism of tumor, also inhibited DNA assimilation in liver of tumor bearing mice. Anticancer supporting substances, esfecially orotic acid, in contrast, could hardly cause any change in DNA metabolism of tumor, but slightly increased RNA metabolism. 3) With regard to nucleic acid metabolism in cancer cells, DNA inhibited cell counts were increased and octoploid cell counts were decreased in case of mitomycin administration. On the other hand, three peak type of cellular arrangement was obtained in case of the administration of supporting substances, showing disturbance of DNA assimilation process. 4) Mitomycin caused disturbance of cell proliferation in early stage of administration course, and also abnormal proliferation and cell destruction. The supporting substances, on the other hand, did not cause any disturbance in process of normal proliferation but accelerated the original degeneration process of tumor eclls as if to drive tumor cells to the final stage of necrosis. en-copyright= kn-copyright= en-aut-name=MatsuuraUmeharu en-aut-sei=Matsuura en-aut-mei=Umeharu kn-aut-name=松浦梅春 kn-aut-sei=松浦 kn-aut-mei=梅春 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1061 end-page=1089 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Catalase Activity of Liver and Plasma Protein Fraction at varions carcinolytic Processes kn-title=各種制癌過程における肝Catalase活性度および血漿蛋白分屑像の推移に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Rabbits bearing Brown-Pearce tumor in liver or muscle were examined and the following results were obtained. 1. As the growth of the tumor progressed, catalase activity of the liver was remarkably depressed and albumin and α-globulin decreased and β-, γ-globulin and Φ-fraction increased in plasma electrophoresis. 2. Injury of reticuloendothelial system of the liver by x-ray irradiation with 1000r on the liver depressed catalase activity of the liver and decreased albumin and β-, γ-globulin and increased α-globulin in plasma electrophoresis. Transplantability of the tumor and mortality were elevated. 3. Carcinolytic agents played the same role on catalase activity of the liver and plasma protein fraction as x-ray irradiation with 1000r on the liver. They are accounted for a gift to the reticuoloendothelial system of the liver. Carcinolytic effect was not observed in Carcinophylin, Mitomycin and Azan. 4. Activation of reticuloendothelial system of the liver by x-ray irradiation with 60r showed carcinolytic effect and the same pattern as that of natural healing was observed in plasma electrophoresis, but catalase activity of the liver was slightly depressed. 5. In cases of natural healing or intransplantable cases, catalase activity of the liver was elevated and plasma protein fraction showed the change from the pattern of tumor growth to the pattern of its recovering process. γ-globulin increased in early stadium. 6. Immunity inhibited the tumor growth markedly and elevated catalase activity of the liver and showed the same pattern in electrophoresis as the cases of natural healing. 7. γ-globulin is considered to play an important role in carcinolytic process, while it does not show carcinolytic effect by itself. en-copyright= kn-copyright= en-aut-name=MimuraHisashi en-aut-sei=Mimura en-aut-mei=Hisashi kn-aut-name=三村久 kn-aut-sei=三村 kn-aut-mei=久 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1(陣内)外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1091 end-page=1096 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Anti-inflammatory Effect and Histamine-release Inhibitory Effect of Some Derivatives of Acetanilide and Pyrazolone kn-title=Acetanilide及びPyrazolone系二,三誘導体の抗炎症作用とHistamine遊離抑制作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Three acetanilide and two pyrazolene derivatives were tested for anti-inflammatory effect on the edema of rat's hind-paws induced by the local injection of dextran, hyaluronidase, formaldehyde, histamine and 5-hydroxyptamine, and for histamine-release inhibitory effect on the rat receiving an intraperitoneal injection of ovomucoid which increases urinary output of histamine as a result of histamine release in the whole body. Phenacetin, acetanilide, aminopyrine, aminopropylone and butazolidine served as controls. GP-I, one of the pyrazolone derivatives (for formula cf. table 1), showed fairly marked supression on all 5 kinds of edema with effects comparable to aminopyrine and butazolidine. Acetanilide derivatives tested, also exerted marked inhibition on the edema other than by hyaluronidase or formaldehyde. All the compounds inhibited the histamine release due to ovomucoid injection, but no graded difference could be seen. en-copyright= kn-copyright= en-aut-name=YamasakiHidemasa en-aut-sei=Yamasaki en-aut-mei=Hidemasa kn-aut-name=山崎英正 kn-aut-sei=山崎 kn-aut-mei=英正 aut-affil-num=1 ORCID= en-aut-name=KondoKazuji en-aut-sei=Kondo en-aut-mei=Kazuji kn-aut-name=近藤和二 kn-aut-sei=近藤 kn-aut-mei=和二 aut-affil-num=2 ORCID= en-aut-name=UdaTeruo en-aut-sei=Uda en-aut-mei=Teruo kn-aut-name=宇田昭夫 kn-aut-sei=宇田 kn-aut-mei=昭夫 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部薬理学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部薬理学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部薬理学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=633 end-page=644 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Anticancer Chemotherapy Especially on the effect of anticancer agents and anticancer supporting substances on the metabolism of cancer bearing mice- PART V The effect of anticancer agents and their supporting substances on serum protein metabolism in the hosts of malignant tumor and also on serum electrolytes kn-title=癌の化学療法に関する研究 特に制癌剤並びに制癌強化剤の担癌生体内代謝に及ぼす影響に就いて 第3編 制癌剤および制癌強化剤の担癌生体血清蛋白代謝に及ぼす影響,並びに血清電解質代謝との相関に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Metabolisms of serum protein and electrolytes in cancer bearing mice were studied to correlate with the effect of anticancer agents and their supporting substances administration. The results obtained are as follows: 1) Serum albumin was decreased in course of cancer progress, which was in negative correlation with ascites increment. 2) Serum Ca tended to decrease, K to increase and Na to fluctuate erratically. 3) The combined administration of anticancer agents and their supportiog substances improved more the liver function to accelerate the assimilation of serum protein and the anticancer resistance, and also improved more serum Ca metabolism than single administration of the anticancer agents in cancer bearing mice. en-copyright= kn-copyright= en-aut-name=MatsuuraUmeharu en-aut-sei=Matsuura en-aut-mei=Umeharu kn-aut-name=松浦梅春 kn-aut-sei=松浦 kn-aut-mei=梅春 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1097 end-page=1106 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Fluorescence-Microscopic Studies on Various Bone Marrow Cells by Tissue Culture Part 1. Fundamental Study on Fluorochrominized Bone Marrow Tissue Culture kn-title=組織培養による骨髄諸細胞の螢光顕微鏡学的研究 第1編 螢光培養法(Fluorochrominized Bone Marrow Tissue Culture)に関する基礎的実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Of late many investigators have come to study blood cells with fluorescence microscope, but most of these works are carried out by supravital staining method only. Therefore, the author has attempted vital observations of bone marrow cells under the fluorescence microscope by adding fluorescent dye, acridine orange, to the medium of the simple tissue culture, the method devised in our department. For this study some fundamental studies have been conducted concerning the toxicity of dye, the selection of barrier filters, the secondary fluorescence of cells, and the influence of exciting rays on the cell growth; and obtained the following results. 1. After studying the relative growth rate, the cell density index, and the wandering velocity of neutrophils it has been found that. tissue culture is possible at low concentration, under 10(-4) of the medium with acridine orange. 2. Barrier filter, OG5 , is the most suitable one for the observation of the secondary fluorescence of the cell. 3. The concentration of the acridine orange medium at which the most distinct picture of fluorescence obtainable is at 10(-4) , and the concentration at 10(-5) is the minimum at which fluorescence can be recognized. 4. The ill effect on cells due to exciting rays may be eliminated by avoiding successive exposure to the rays. 5. The author has devised a medium for the bone marrow tissue culture, consisted of a drop of serum and a drop of physiological saline solution containing 80 γ / cc vitamin B(12) and 0.2 mg / cc acridine orange, and has designated this as the simple method of fluorochrominized bone marrow tissue culture. en-copyright= kn-copyright= en-aut-name=WatanabeSusumu en-aut-sei=Watanabe en-aut-mei=Susumu kn-aut-name=渡辺晋 kn-aut-sei=渡辺 kn-aut-mei=晋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=645 end-page=648 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Case Report of Ulcerative Colitis at right Colon kn-title=右側結腸に発生した潰瘍性大腸炎の治験例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It has been known that there are numerous reports in Europe and America but few in Japan with regard to ulcerative colitis of which the first report was done by Wilks and Moxon in 1875, especially to segmental ulcerative colitis. This is the report of one case of our experience. The colitis was localized at right colon with typical pseudopolyposis and was undergone surgery resulting in a complete cure. Segmental ulcerative colitis tends to originate at right colon and extend toward both oral and anal directions, and it is, therefore, mandatory to resect it surgically when it is localized at right colon, so-called at the stage of the right-sided colitis. In order to fulfill it with making the early diagnosis, the x-ray examination should be very carefully done at right colon in clinically suspected case of ulcerative colitis without any abnormal finding at romanoscopic examination. en-copyright= kn-copyright= en-aut-name=MatsuuraUmeharu en-aut-sei=Matsuura en-aut-mei=Umeharu kn-aut-name=松浦梅春 kn-aut-sei=松浦 kn-aut-mei=梅春 aut-affil-num=1 ORCID= en-aut-name=SatoMinoru en-aut-sei=Sato en-aut-mei=Minoru kn-aut-name=佐藤実 kn-aut-sei=佐藤 kn-aut-mei=実 aut-affil-num=2 ORCID= en-aut-name=SasakiSumizi en-aut-sei=Sasaki en-aut-mei=Sumizi kn-aut-name=佐々木澄治 kn-aut-sei=佐々木 kn-aut-mei=澄治 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部砂田外科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1160 end-page=1172 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber den Zucker-, Fettstoffwechsel und die passive Anaphylaxie bei experimenteller Kaninchenclonorchiasis sinensis (3. Mitteilung.) Der Anaphylaxieversuch bei Kaninchenclonorchiasis kn-title=實驗的肝臟「ヂストマ」病家兎ニ於ケル糖代謝,脂肪代謝竝ニ被働性過敏症ニ就テ 第3報 被働性過敏症ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bei der Clonorchiasis sinensis treten, wie allgemein bekannt, eine deutliche pathologisch-histologische Ver?nderung der Leber, Zirkulationsst?rung im Pfortadersystem, Ikterus etc. auf. So hat Verfasser, der in der I. und 2. Mitteilung ?ber die St?rung des Zucker- und Fettstoffwechsels bei experimenteller Kaninchenclonorchiasis sinensis berichtet hatte, in dieser Mitteilung einen passiven Anaphylaxieversuch, den er an den mit dieser Krankheit infizierten Kaninchen ausgef?hrt hat, beschrieben. Sowohl normale wie auch erkrankte erwachsene Kaninchen wurden zuerst mit Antirinderkaninchenimmunserum sensibilisiert. Allen diesen Tieren wurde nach einer Inkubationszeit von 24 Stunden eine gleiche Einheitsmenge Antigen reinjiziert, dann wurde der Blutdruck an der Carotis mit dem Quecksilbermanometer und Kimographion und der Serumpr?zipitintiter der Versuchstiere vor und nach der Reinjektion beobachtet. Bei den normalen Kaninchen trat bald nach der Reinjektion eine deutliche und typische Blutdrucksenkung auf, w?hrend sich bei den erkrankten Kaninchen keine oder eine nur geringe und atypische Blutdrucksenkung erkennen liess. Was die Abnahme des Pr?zipitintiters nach der Reinjektion anbelangt, so war sie bei gesunden und infizierten Tieren fast gleich. en-copyright= kn-copyright= en-aut-name=UyenoHiroshi en-aut-sei=Uyeno en-aut-mei=Hiroshi kn-aut-name=上野博 kn-aut-sei=上野 kn-aut-mei=博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學法醫學教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=649 end-page=663 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Localization Study of Epileptogenic Focus by Means of Intracarotid Sodium Amobarbital Injection Part 1 Intracarotid Sodium Amobarbital Injection Effect on Experimentally Produced Focal Epileptogenic Discharge of Cat kn-title=アモバルビタールソーダ頸動脈注射によるてんかん焦点局在診断に関する研究 第1編 実験的てんかん焦点に対するアモバルビタールソーダ頸動脈注射の影響に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Twenty adult cats were utilized for this study under unanesthetized condition. Penicillin was locally given in various parts of cortex and subcortical nucleus or thalamus to elicit epileptogenic discharges and sodium amobarbital was intracarotidly injected to give arise transient functional depression of hemisphere. EEG was followed up in the course of this experiment. 1) Local application of penicillin into cortex or subcortical nucleus or thalamus considerably elicited epileptogenic discharges. 2) In case of focal cortical epileptogenic discharge, the first spike appearing at the neighbouring area of the focus was followed to be associated with the synchronous spike discharge at the opposite side and then the focal seizure discharge was built. The discharge was occaionally interrupted by the interictal state, building, in some of the cases, the final stage of generalized seizure discharge. 3) So was noted in its appearance and process in case of focal subcortical epileptogenic discharge. But there was a more tendency of transmission of its activity to the opposite side in comparison with the cortical epileptogenic discharge. 4) The epileptogenic discharge originated from unilateral cortical focus was abolished or inhibited by means of ipsilateral intracarotid injection of 5 to 10 mg sodium amobarbital, but was not affected by the contralateral administration. However, either side of the injection could not inhibit the discharge activity after it became a focal seigure discharge. 5) Subcortically elicited epileptogenic discharge, in contrast, could not be interfered by either side of the intracarotid administration. 6) In cases of both focal cortical and subcortical discharge, intracarotid injection of sodium amobarbital manifested a tendency of flattening and slowing of back ground activity at the injected side, but not at the opposide side. 7) The intracarotid administration could not activate the epileptogenic discharges either from cortex and subcortex. en-copyright= kn-copyright= en-aut-name=YagiTakeshi en-aut-sei=Yagi en-aut-mei=Takeshi kn-aut-name=八木健 kn-aut-sei=八木 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1107 end-page=1117 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Flucrescence-Microscopic Studies on Various Bone Marrow Cells by Tissue Culture Part 2. Vital observations on Blood Cells of Normal Persons by Means of Fluorochrominized Bone Marrow Tissue Culture kn-title=組織培養による骨髄諸細胞の螢光顕微鏡学的研究 第2編 螢光培養法(Fluorochrominized Bone Marrow Tissue Culture)による正常人血液細胞の生態観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the present experiment the author conducted the bone marrow tissue of normal persons by the simple method of fluorochrominized bone marrow tissue culture as established in Report 1, and observed the growth zone and various bone marrow cells appearing in the zone. 1. The cells are dense in the central part of the growth zone, and the density gradually decreases towards the periphery, giving off reddish orange fluorescence diffusely with yellow and green fluorescent spots scattered in this zone. 2. Cytoplasma, is green, while mitochondria and various granules give off yellowish green or reddish orange fluorescence. However, the fluorescence of mitochondria is quite trivial, and the nuclei and nucleoles are green but nucleoles give off fluorescence earler than the nuclei. 3, In young cells green fluorescence of cytoplasma is marked, and it grows less distinct as they mature whereas reddish orange granules tend to increase along with the maturation of cells and their size is variegated. 4. In myelogenous cells reddish orange fluorescence of granules is characteristic while yellowish green fluorescence of the nuclei in lymphocytic cells. In mouocytic cells a variety of fluorescence such as green cytoplsama and reddish orange granules agglomerating around the nucleus can be recognized, and likewise fluorescence specific to each cell type can be observed in other cells. 5. The green fluorescence of cytoplasma of erythroblasts is gradually lost along with maturation, and no fluorescence can be recognized in erythrocytes, while substantia reticulofilamentosa of reticulocytes present red fluorescence. 6. When two barrier filters, GG 4 and OG 4 are used together, it is easy to differentiate cells of the erythroblast series from cells of the leucocyte series. en-copyright= kn-copyright= en-aut-name=WatanabeSusumu en-aut-sei=Watanabe en-aut-mei=Susumu kn-aut-name=渡辺晋 kn-aut-sei=渡辺 kn-aut-mei=晋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=665 end-page=673 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Localization Study of Epileptogenic Focus by Means of Intracarotid Sodium Amobarbital Injection Part 11 Intracarotid Sodium Amobarbital Injection Effect on Human EEG kn-title=アモバルビタールソーダ頸動脈注射によるてんかん焦点局在診断に関する研究 第2編 アモバルビタールソーダ頸動脈注射の脳波基礎律動に及ぼす影響に関する臨床的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=An attempt was made to analyze the changes of EEG secondary to the intracarotid injection of 50 to 100 mg of sodium amobarbital: 33 trials on 20 patients. 1) There appeared to be a marked change in all cases; limited or dominant ipsilaterally to the side of administration. 2) The latter was found in 22 out of 33 trials, and noted at the records of the frontal leads. 3) The change was composed of high amplitude and low frequency or of low amplitude and high frequency or of the mixed of both, occurring at 3 to 6 seconds after the onset of the injection and gradually disappearing to regain the normal state within 30 minutes. 4) These changes, especially the high amplitude and slow waves immediately after the injection at the same side were markedly noticed when the injection was in large dosage and in high speed. 5) There was no difference in such changes given arise by either side of administration in the same patient. 6) It is to be noted that there were no hazardous complications at the intracarotid injection of 10 % sodium amobarbital under sufficient attention. en-copyright= kn-copyright= en-aut-name=YagiTakeshi en-aut-sei=Yagi en-aut-mei=Takeshi kn-aut-name=八木健 kn-aut-sei=八木 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1119 end-page=1132 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Fluorescence-Microscopic Studies on Various Bone Marrow Cells by Tissue Culture Part 3. A Study on Degeneration of Leucocytes and on the Relationship between Cell Function and Fluorescence kn-title=組織培養による骨髄諸細胞の螢光顕微鏡学的研究 第3編 白血球の変性並に細胞機能と螢光との関係に関する研究 附.全編の総括 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By performing the simple method of fluorochrominized bone marrow tissue culture the author observed the degeneration picture of leucccytes, and also studied changes in fluorescence in the cells cultured under an adverse condition but added with acridine orange. The following are the results of the present experiment. 1. It has been found that the majority of commonly-known findings by supravital staining are proven to be degeneration picture of cells. 2. As for the degeneration signs, the swelling and fading of reddish orange granules can be pointed out, while in cytoplasma vacuoles either stained or unstained with acridine orange, abnormal processes, the reddening or green swelling of cytoplasma can be recognized: The nuclei have agglutinated chromatin and have become yellow, red, and swollen in green color, and in nucleoles green swelling or reddening can be observed. 3. In the degeneration picture likewise each cell type present different fluorescence. 4. When cells become shrunk, the fluorescence is red, while when cells are swollen, it is green. 5. In the cells with decreased function reddish orange granules fade quickly and their nuclei turn yellow. 6. Those cells that have lost the fluorescence of their granules, and those that have red cytoplasma and red nuclei as well as those with their nuclei green and swollen as all-dead cells. en-copyright= kn-copyright= en-aut-name=WatanabeSusumu en-aut-sei=Watanabe en-aut-mei=Susumu kn-aut-name=渡辺晋 kn-aut-sei=渡辺 kn-aut-mei=晋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=675 end-page=693 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Localization Study of Epileptogenic Focus by Means of Intracarotid Sodium Amobarbital Injection Part 111 Differentiation of Primary and Secondary Bilaterally Synchronous Spike and Wave Complex kn-title=アモバルビタールソーダ頸動脈注射によるてんかん焦点局在診断に関する研究 第3編 1次的及び2次的両側同期性棘徐波複合の鑑別に関する臨床的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Intracarotid injection of 50 to 100 mg of 5 to 10 % sodium amobarbital was given to 30 cases of epileptics, and change of the abnormal EEG was followed. 1) Unilateral focal cortical epileptogenic spikes were abolished by the ipsilateral administration, but not by the contralateral. 2) Amongst the cases of bilaterally synchronous spike and wave complex, two types of marked responses were obtained at the administration. One group manifested an abolishment of the complex from all leads of both hemispheres by administration on one side, but a transient inhibition of the spike component from the ipsilateral hemisphere by administration on the other side. This appears to indicate the complex originates from unilateral cortical focus which is located at the first side. This group may correspond with the secondary bilateral synchrony. 3) Another group manifested a transient inhibition of the spike component from ipsilateral hemisphere without abolishment of the complex at either side of administration. This may correspond with the primary bilateral synchrony, the so-called "ceutrencephalic origin". 4) No activation of characteristic abnormal activities in epileptics was found at the intracarotid injection of sodium amobarbital. en-copyright= kn-copyright= en-aut-name=YagiTakashi en-aut-sei=Yagi en-aut-mei=Takashi kn-aut-name=八木健 kn-aut-sei=八木 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1155 end-page=1178 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Lymphoid Tumors of Mice Induced by 20-Methylcholanthrene Part 2. Studies on the Process of Development of Lymphocytic Leukemia kn-title=2-Methylcholanthreneによるハツカネズミリンパ性腫瘍の研究 第2編 リンパ球性白血病の成立過程に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=After inducing lymphocytic leukemia by painting the skin of the mice of dba strain and other group of uncertain origin with 20-methylcholanthrene, the author carried out tissuc cultures of bone marrow, lymph nodes, and spleen of these test animals and also cytological and histological examinations for purpose of clarifying the origin and development of lymphocytic leukemia. On the basis of the peripheral blood pictures, the author classified the development of lymphocytic leukemia into the following three stages, i.e., (1) preleukemic stage (with leucopenia but no lymphoblasts in the peripheral blood), (2) initial stage of leukemia (with slight leucocytosis and a few lymphoblasts in the peripheral blood), and (3) advanced stage of leukemia (with marked leucocytosis and many lymphoblasts in the peripheral blood). The following are the results and conclusions of the present experiment. (1) The changes in the peripheral blood pictures observed during the preleukemic stage as described in Part I, that is, leucopenia and lymphopenia, are caused by the arrest of maturation in lymph follicles of the spleen and by hypoplasia of lymph nodes. Eosinophilia can be observed in bone marrow of every single case and the stimulation of the reticuloendothelial system is believed to be one of its causes. Lymphoblasts of the peripheral blood during the initial stage of leukemia are mainly derived from the spleen. The distribution curve of the greatest diameters of lymphocytes in the peripheral blood gradually shifts to the right as lymphocytic leukemia develops. This phenomenon coincides with the increase in large lymphocytes during the preleukemic stage and with the appearance of lymphoblasts during the initial stage of leukemia. (2) In tissue cultures, the bone marrow, spleen, thymus, and lymph nodes of leukemic mice show the growth patterns specific to acute lymphocytic leukemia, though these ars not so typical in mice as in men. Namely, the margin of growth zone is sharply defined, the density of cells is very high, and the growth zone is consisted mainly of lymphoblasts with some mature lymphocytes. In the preleukemic stage, the spleen shows relatively leukemic growth pattern, but the lymph nodes show hypoplasia or slight hyperplasia, In the initial stage of leukemia, the spleen shows the leukemic growth pattern, but the lymph nodes and thymus show hyperplasia or leukemic growth pattern. In the advanced stage of leukemia, the spleen, lymph nodes, thymus, and the bone marrow begin to show the leukemic growth pattern. (3) Cytomorphologically, leukemic cells appear first of all in the lymph follicles of the spleen, and they increase in the lymph nodes and bone marrow along with progress of leukemia. The lymphoblats in the lymph nodes during the preleukemic and initial stages of leukemia are little atypical, but they show prominent nucleoli and lobulation of the nucleus in the advanced stage and also mitochondria increase in number. The distribution curve of the greatest diameters of lymphocytes in the lymph nodes shifts gradually to the right through the development of lymphocytic leukemia as in the case of peripheral blood. (4) In autopsy findings, there can be observed a slight enlargement of spleen in the preleukemic stage, moderately enlarged spleen and slightly enlarged lymph nodes in the initial stage, and marked enlargement of spleen, lymph nodes, and liver in the advanced stage. (5) Histologically, the lymph follicles of spleen are enlarged due to the proliferation of reticulum cells and lymphoblasts in the preleukemic stage. Lymph nodes show hypoplasia or slight hyperplasia. Namely, lymphocytic leukemia can be understood to be circumscribed to the spleen in this stage. In the initial stage, lymphoblasts infiltrate diffusely through the whole spleen and lymph nodes show hyperplasia or gradual enlargement of germinal centers due to the proliferation of lymphoblasts with the formation of lymph follicles. In the bone marrow, diffuse infiltration of leukemic cells can be observed. In the advanced stage, spleen, lymph nodes, and thymus become totally leukemic, and leukemic cells metastasize to various other organs including bone marrow, liver, and kidneys through the hematogenous and lymphogenous channels. (6) Leukemia sets in about the time when papilloma appears on the skin, and by the time when papilloma begins to be transformed into skin cancer most of the mice with lymphocytic leukemia die. The mice with skin carcinoma show myelogenous leukemoid reaction, and some of them reveal the complication of reticulosis or reticulosarcomatosis. en-copyright= kn-copyright= en-aut-name=OkadaKoichi en-aut-sei=Okada en-aut-mei=Koichi kn-aut-name=岡田耕一 kn-aut-sei=岡田 kn-aut-mei=耕一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1179 end-page=1195 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Lymphoid Tumors of Mice Induced by 20-methylcholanthrene Part 3. Studies on the Relationship between Lymphocytic Leukemia and Lymphocytic Leukosarcomatosis kn-title=20-Methylcholanthreneによるハツカネズミリンパ性腫瘍の研究 第3編 リンパ球性白血病,リンパ球性白血肉腫症,リンパ肉腫症の異同に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With lymphoid tumors (lymphocytic leukemia and lymphocytic leukosarcomatosis) induced in the mice of uncertain origin by smearing with 20-methylcholanthrene, the author tried to clarify the relationship between lymphocytic leukemia and lymphocytic leukosarcomatosis by performing bone-marrow and lymph-node tissue cultures in combination with cytological examinations, and obtained the following results. (1) Lymphocytic leukosarcomatosis is mostly aleukemic, and the percentage of lymphoblasts in the peripheral blood is low. Some cases of lymphocytic leukosarcomatosis reveal a marked increase of large lymphocytes in the peripheral blood. (2) The lymph nodes and bone marrow of aleukemic lymphocytic leukosarcomatosis consist mostly of lymphosarcoma cells with the greatest diameters of more than 15.3μ and marked lobulation of the nucleus. These cells are thought to be derived from Amano's "lymphogonia". In addition, in the lymph nodes and bone marrow of aleukemic lymphocytic leukosarcomatosis, there can also be found little atypical lymphoblasts with the greatest diameters of less than 15.3μ, what may be considered as leukemic cells. and it seems that those lymphoblasts found in the peripheral blood of leukosarcomatosis are derived from these leukemic cells. (3) The lymph nodes and bone marrow of aleukemic lymphocytic leukosarcomatosis are consisted mostly of lymphosarcoma cells, while, in leukemic lymphocytic leukosarcomatosis and lymphocytic leukemia, the percentage of leukemic cells increases and the percentage of lymphosarcoma cells decreases. (4) In the bone-marrow and lymph-node tissue cultures, aleukemic lymphosarcomatosis generally presents the growth pattern resembling tumor, while leukemic lymphocytic leukosarcomatosis shows the growth pattern exactly similar to that of acute lymphocytic leukemia. (5) In autopsy findings, lymphocytic leukosarcomatosis shows more remarkable enlargement of lymph nodes than lymphocytic leukemia. Histologically, in aleukemic lymphocytic leukosarcomatosis there is little tendency of lymphoblast infiltration and metastasis to the liver and kidneys. (6) Since aleukemic and leukemic leukosarcomatosis can transform progressively to lymphocytic leukemia, all these are believed to be essentially the same disease. en-copyright= kn-copyright= en-aut-name=OkadaKoichi en-aut-sei=Okada en-aut-mei=Koichi kn-aut-name=岡田耕一 kn-aut-sei=岡田 kn-aut-mei=耕一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1173 end-page=1190 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber die Embryonalentwicklung von Paragonimus westermanni kn-title=肺臟「ヂストマ」ノMiracidiumノ發育 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verf. studierte die Miracidiumentwicklung von Lungendistoma haupts?chlich mit dem gef?rbten Schnittpr?parate derselben Larve, die er aus der Distomeneier k?nstlich gebr?tet hatte. Nach seiner genaueren Beobachtung vertritt er die Ansicht, dass diese Larve in ihrer Entwicklung mit der Schistosomalarve eine sehr grosse Analogie hat, weil alle K?rperteile und H?llmembrane dieses Wurmes sich in fast gleicher Entstehungsweise wie bei der Schistosomalarve entwickeln. Aber einige Organe z. B. die einzellige Dr?se und der linsenartige K?rper scheint sich bei dieser Larve nicht zu entwickeln. en-copyright= kn-copyright= en-aut-name=WatanabeMasumi en-aut-sei=Watanabe en-aut-mei=Masumi kn-aut-name=渡邊眞澄 kn-aut-sei=渡邊 kn-aut-mei=眞澄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學細菌學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1197 end-page=1201 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Effect of the Unsaturated Fatty Acid Fraction from the Liver of Irradiated Rabbit on the Fertilization and Cell Division kn-title=放射線照射家兎肝より抽出せる細胞毒のウニ卵及び精子に与える影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effect of unsaturted fatty acid fraction from the liver of irradiated animal on fertilization and cell division of sea urchin egg (Hemicentrotas tulcherrimus) have been observed. The sperms exposed to the substance for 5 minutes decrease in their mortility and lost the fertilization acivitity resuting in the lose of their ability for the formation of fertilizing membrae in eggs. The eggs exposed to this substance after fertilization present the stop or the delay in their cleavage. Such an action on eggs becomes marked when the concentration of this substance increases. The most susceptible stage seems to be the metaphase at which the chromosoms are arrested on the equatolial plate loosing the tendency to move toward the poles. These effects of this substace can be seen even after removing the peroxide as equally in the original substance. en-copyright= kn-copyright= en-aut-name=SenoSatimaru en-aut-sei=Seno en-aut-mei=Satimaru kn-aut-name=妹尾佐知丸 kn-aut-sei=妹尾 kn-aut-mei=佐知丸 aut-affil-num=1 ORCID= en-aut-name=YamamotoMichio en-aut-sei=Yamamoto en-aut-mei=Michio kn-aut-name=山本道夫 kn-aut-sei=山本 kn-aut-mei=道夫 aut-affil-num=2 ORCID= en-aut-name=UtsumiKozo en-aut-sei=Utsumi en-aut-mei=Kozo kn-aut-name=内海耕慥 kn-aut-sei=内海 kn-aut-mei=耕慥 aut-affil-num=3 ORCID= en-aut-name=ShiakuMidori en-aut-sei=Shiaku en-aut-mei=Midori kn-aut-name=塩飽緑 kn-aut-sei=塩飽 kn-aut-mei=緑 aut-affil-num=4 ORCID= en-aut-name=AkagiKeiko en-aut-sei=Akagi en-aut-mei=Keiko kn-aut-name=赤木瑩子 kn-aut-sei=赤木 kn-aut-mei=瑩子 aut-affil-num=5 ORCID= en-aut-name=IguchiYoshico en-aut-sei=Iguchi en-aut-mei=Yoshico kn-aut-name=井口与志子 kn-aut-sei=井口 kn-aut-mei=与志子 aut-affil-num=6 ORCID= en-aut-name=UenoHisako en-aut-sei=Ueno en-aut-mei=Hisako kn-aut-name=上乃寿子 kn-aut-sei=上乃 kn-aut-mei=寿子 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部病理学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1203 end-page=1208 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Nature of X-Ray Disturbance Part I. Effect of Unsaturated Fatty-Acid Fraction Extracted from X-Ray Irradiated Rabbit-Liver on Succinic Dehydrogenase System of Ehrlich-Ascites-Tumor Cells kn-title=X線照射時に発生せる細胞毒の研究について 第一編 X線照射家兎より抽出した不飽和脂肪酸分画のEhrlich腹水癌,正常肝のコハク酸脱水素系に及ぼす影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=There are many investigations on the disturbances caused by x-rays but these works are consisted mainly of histo-morphological researches and rerely from the viewpoint of the acting mechanism of cells. More recently Lea, Barron et al, however, have studied the histochemical changes in the animals irradiated with x-rays and they have clarified the direct action of x-ray irradiation to a certain extent. In our laboratory Dr. Yamamoto has succeeded in isolating a certain cytotoxin from unsaturated fatty acid fraction, an extract of the liver of the rabbits exposed to x-rays. In the subsequent studies with this cytotoxin it has been found that this substance has an inhibitory action on the mitosis of tumor cells. Therfore, we have carried out a series of experiments to see the effect of this substance, in the presence of succinic dehydrogenase, on the respiration of Ehrlich-ascites-tumor cells. As the result it has been confirmed that this cytotoxin possesses an action as to depress both the respiration of the cancer cell and that of normal liver cells. en-copyright= kn-copyright= en-aut-name=ShiakuMidori en-aut-sei=Shiaku en-aut-mei=Midori kn-aut-name=塩飽緑 kn-aut-sei=塩飽 kn-aut-mei=緑 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1209 end-page=1221 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the Effect of the Various Extracts In the Course of Infection with Infectious Hepatitis Virus. I) The Effect of the Various Bacterial Extracts II) The Effect of the Organ Extracts of the Animal kn-title=流行性肝炎ウイルス感染過程に及ぼす諸種抽出物質の影響について (I) 細菌性抽出物質の影響 (II) 動物臓器抽出物質の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The influence of the various extracts of various bacteria and organs of animals on the infections aspect of hepatitis virus was studied by the histopathological findings in the inoculated mice. According to the results of experiments, some extracts showed inhibitory action and someone revealed promoting effect, but also others were no influence on the course of infection. It was nucleic acid and nucleo protein that were extracted from cholera vibrio which was inhibitory effect. The Proteins which were extracted from Typhoid bacillus showed raising effect on the sensitivity of the mouse against the infectious hepatitis virus. It will be found more effective substances which have inhibitory action, if further studies are performed on the other various substances. en-copyright= kn-copyright= en-aut-name=TakahashiManabu en-aut-sei=Takahashi en-aut-mei=Manabu kn-aut-name=高橋学 kn-aut-sei=高橋 kn-aut-mei=学 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1223 end-page=1226 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Significance of Blood Sedimentation Rate in Disseases of Cancer kn-title=癌疾患と赤血球沈降反応 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Change of blood sedimentation rate before and after therapy were examined in 50 patients of cancer. 1) Before therapy, only 6 patients (12%) were normal extent. 2) It was cancer of lung which tendency to increase was much more stronger than otlrers. 3) Cases in which couse after therapy (Operaeion or X. ray therapy) was good, blood sedimentation rate returned to normal extent. 4) It will be find out complication, if periodic examination of blood sedimentation rate after operation was performed. en-copyright= kn-copyright= en-aut-name=TakahashiManabu en-aut-sei=Takahashi en-aut-mei=Manabu kn-aut-name=高橋学 kn-aut-sei=高橋 kn-aut-mei=学 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=香川県立中央病院外科 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1227 end-page=1241 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Fibrinolysis Following Massive Transfusion of Preserved Blood, and on the Treatment Part 1. Experimental and clinical studies on the mechanism of fibrinolysis kn-title=保存血大量輸血に伴う出血傾向に対する線維素溶解現象の発現とその対策 第1編 保存血大量輸血時の線維素溶解現象発現機序に対する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The mechanism of fibrinolysis following massive transfusion of preserved blood was investigated, clinically and experimentally. Results obtained were as follows: 1. Fibrinolytic activity was not seen in the preserved blood, and the fibrinolysis observed in the transfusion of preserved blood was derived from preserved blood itself which acted upon as a stress, but it was slight in the degree. On the other hand, the fibrinolysis was relatively remarkable in the cases undertaking sugical procedures, especially a pulmonary operation, and etc. However, it was not considered that either one of above cases would become to develop a hemorrhagic tendency. 2. Fibrinogen level did not show a remarkable change with a massive transfusion of preserved blood, but was decreased in the cases operated upon the organs being high in the thromboplastin level and became a cause of a hemorrhagic tendency. 3. A hemorrhagic tendency was not always observed even in the cases showing highly positive fibrinolysis, but it was thought to be cased by the defects in platelet, vascular and coagulation factors of many kinds, in conjuction with the changes in general and local conditions of patients, and with surgical procedures. The fibrinolysin, however, promoted the development of hemorrhagic tendency following the disturbances in vascular and various kinds of coagulation factors. en-copyright= kn-copyright= en-aut-name=OnoMasayosi en-aut-sei=Ono en-aut-mei=Masayosi kn-aut-name=小野晶美 kn-aut-sei=小野 kn-aut-mei=晶美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1243 end-page=1253 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Fibrinolysis Following Massive Transfusion of Preserved Blood, and on the Treatment Part U. Experimental Studies on the Treatment of Fibrinolysis Following Massive transfusion of Preserved blood kn-title=保存血大量輪血に伴う出血傾向に対する線維素溶解現象の発現とその対策 第2編 保存血大量輸血時の線維溶解現象発現に対する対策 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Therapeutic and prophylactic measures against a fibrinolysis following massive transfusion of preserved blood was studied, and following results were obtained. 1. Administration of ε-aminocaplonic acid, ACTH, and cortisone prevented a fibrinolysis following massive transfusion of preserved blood. 2. These therapeutics, especially, showed a marked preventive effect when they were applied together at early stage. 3. At the same time in the cases administed together with thromboplastin and adrenochrome preparations of every kinds as well as fresh blood, fibrinolysis was not completely prevented, but those were expected to inhibit other disturbance in coagulation mechanism accompanied with the above phenomenon. en-copyright= kn-copyright= en-aut-name=OnoMasayosi en-aut-sei=Ono en-aut-mei=Masayosi kn-aut-name=小野昌美 kn-aut-sei=小野 kn-aut-mei=昌美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1255 end-page=1260 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Infulences of free Amino acid on Glucose Metabolism in the Brain. Part V. Infulences of Continuing Administration of Amino Acid on Glucose Metabolism in the Cerebral Cortex of Rabbit with Convulsion kn-title=脳のglucose代謝におよぼすamino酸の影響に関する研究 第3編 痙攣家兎大脳皮質のglucose代謝およびそれにおよぼすamino酸連続投与の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Convulsions were repeatedly caused by electrical stimulation in rabbits. Total free amino acids contents in these rabbits showed no fluctation, while glucose metabolism decreased like as in those with latent cerebral local anaphylaxis and human epileptics. The glucose utilization was cured to normal level by continuing injection of Glutamic acid, GABA, and Asparagine, but total amino-N changed scarecely. It is an important fact, that free amino-N content increased by GABA injection in rabbits with convulsion. en-copyright= kn-copyright= en-aut-name=YamamotoYasuhisa en-aut-sei=Yamamoto en-aut-mei=Yasuhisa kn-aut-name=山本泰久 kn-aut-sei=山本 kn-aut-mei=泰久 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1(陣内)外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=739 end-page=742 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Three Cases of Oesophageal Hiatus Hernia kn-title=最近我々の遭遇せる食道裂孔ヘルニアの3例に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=There are sometimes patients of oesophageal hiatus hernia who visit our clinic complaining gastrointestinal disturbances similiar to stomach cancer or gastric ulcer and symptoms of breast disease. Recently we came upon three of these cases so as would like to report. en-copyright= kn-copyright= en-aut-name=YamamotoMichio en-aut-sei=Yamamoto en-aut-mei=Michio kn-aut-name=山本道夫 kn-aut-sei=山本 kn-aut-mei=道夫 aut-affil-num=1 ORCID= en-aut-name=NishishitaSoichi en-aut-sei=Nishishita en-aut-mei=Soichi kn-aut-name=西下創一 kn-aut-sei=西下 kn-aut-mei=創一 aut-affil-num=2 ORCID= en-aut-name=AonoKaname en-aut-sei=Aono en-aut-mei=Kaname kn-aut-name=青野要 kn-aut-sei=青野 kn-aut-mei=要 aut-affil-num=3 ORCID= en-aut-name=TanadaMasatada en-aut-sei=Tanada en-aut-mei=Masatada kn-aut-name=田辺正忠 kn-aut-sei=田辺 kn-aut-mei=正忠 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部癌研究所/岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=川崎病院/川崎癌研究所放射線科/岡山大学医学部 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1191 end-page=1199 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber eine neue Art von Trematoden, Exorchis major n. sp., welches als Zwischenwirt Plecoglossus altivelis hat kn-title=鮎ヲ中間宿主トスル1新吸蟲Exorchis major n. sp.ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verfasser sammelt viele Plecoglossus altivelis aus Okayama Provinz und verschiedenen bekannten Heimaten von ganzen Japan und untersuchte die enzystierte Zerkarien, welche sich bei ihnen ern?hren. Er fand die enzystierte Zerkarie von Metagonimus yokogawai, Echinokasmus perfoliatus, Echinokasmus japonicus und die eines unbekannten Trematodes. Nach genauen Untersuchuugen ?ber die letztere erkannte er, dass ihre Mutter ein neues Trematodes war, und ein anderes als Exorchis oviformis Kobayashi, obwohl sie denselben Endwirt und dieselbe biologischen Eigenschaften hatte. Verfasser benannte sie Exorchis major n. sp. und stellte den Bau des K?rpers mit einem Bild eingehend dar. en-copyright= kn-copyright= en-aut-name=HasegawaTsuneji en-aut-sei=Hasegawa en-aut-mei=Tsuneji kn-aut-name=長谷川恒治 kn-aut-sei=長谷川 kn-aut-mei=恒治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學細菌學教室 END start-ver=1.4 cd-journal=joma no-vol=43 cd-vols= no-issue=2 article-no= start-page=397 end-page=401 dt-received= dt-revised= dt-accepted= dt-pub-year=1931 dt-pub=19310228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber die motorische Nervenendigung im Herzmuskel beim Kaninchen kn-title=心筋ニ於ケル運動性神經終末ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=In Bezug auf die motorische Nervenendigung im Herzmuskel sind die Berichte der mehreren Autoren verschiedenartig. Einige behaupten, dass die motorische Nervenfaser an der Oberfl?che der Muskelfaser endigt, w?hrend nach anderen sie innerhalb der Muskelfaser ihr Ende findet. Um diese Frage zu l?sen hat der Verfasser die Nervenendigung im Herzmuskel beim Kaninchen mittelst der Silberimpr?gnation nach R. y. Cajal und der supravitalen Methylenblauf?rbung untersucht. Es ergibt sich, dass terminals Nervenfasern von ca. 100-150μ L?nge an der Oberfl?che gewisser Muskelfasern, besonders in der N?he des Muskelkerns mit sehr feinen kn?pfchenartigen Verdickungen endigen, was als echte motorische Nervenendigung im Herzmuskel gilt (Fig. 5, 6 u. 7). en-copyright= kn-copyright= en-aut-name=OkadaShinichi en-aut-sei=Okada en-aut-mei=Shinichi kn-aut-name=岡田眞一 kn-aut-sei=岡田 kn-aut-mei=眞一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學解剖學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1200 end-page=1216 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber die histologische Ver?nderung der Herzmuskulatur, Unterkieferdr?se, Ohrspeicheldr?se, Leber, Niere, und Milz, die durch Amylnitrit zutage tritt kn-title=亞硝酸「アミール」ノ爲メ起ル心筋,顎下腺,耳下腺,肝臟,腎臟竝ニ脾臟ノ組織學的變化ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bei Kaninchen injizirte der Verfasser Amylnitrit in die Ohrvene, und zwar zuweilen so viel bis die Tiere sterben, zuweilen nur ein Zehntel der Dosis letalis. Im letzteren Falle t?tete der Verfasser die Tiere 20 Minuten, 1, 3, 6, 12, 24, 48 und 72 Stunden nach der Injektion. Nach Sterben der Tiere wurde ein St?ck jedes Organes m?glichst schnell herausgenommen und histologisch untersucht. Ausserdem unterband der Verfasser bei Kaninchen die Milzarterie oder Milzvene und t?te die Tiere bald danach durch Luftembolie oder durch die Injektion des Amylnitrites, um ihren Milzbefund mit der Folgeerscheinung der einfachen Injektion zu vergleichen. Daraus ergibt sich das Folgende: 1) Nach Injektion des Amylnitrites erweitern sich gr?ssere Blutgef?sse im Herzen, in der Unterkieferdr?sen, Ohrspeicheldr?se, Niere und Milz, wobei sich die Intima, die glatten Muskelfasern der Media, sowie das Bindegewebe der Adventitia in ihrer verd?nnten Wand dehnen. Die glatten Muskelfasern vereinigen sich stellenweise und bilden kleine B?ndel, die locker vorhanden sind. In der Leber sicht man diesen Zustand 20 Minuten nach der Injektion, w?hrend die Gef?sse des Herzens und der Niere sich unmittelbar nach der Injektion erweitern und schon nach 20 Minuten eine Wiederherstellung zeigen. Die kleinen Gef?sse, besonders Kapillaren und kleine Venen eweitern sich sehr verschiedenartig je nach dem Organe, indem der Grad und die Dauer der Erweiterung eine grosse Schwankung zeigen. Die Gef?sserweiterung in der Unterkieferdr?se, Ohrspeicheldr?se, Niere und Milz tritt unmittelbar nach der Injektion auf und springt in die Augen 20 Minuten lang, w?hrend sie nach einer Stunde zur?cktritt. Dagegen dauert sie im Herzen 12 Stunden, in der Leber 6 Stunden und im Nierenglomerulus sogar 48 Stunden lang, wobei ihr Grad im Herzen am st?rksten ist. 2) Amylnitrit l?sst die Parenchymzellen verschiedener Organe aufquellen und die Speichelsekretion bef?rdern. Die Herzmuskelfasern zeigen bis 20 Minuten nach der Injektion keine deutliche Ver?nderung, doch quellen sie eine Stunde nach der Injektion auf und zeigen eine lockere Struktur. 3 Stunden nach der Injektion sind sie infolge der starken Erweiterung der Blutkapillaren stark gedr?ckt, aber von der 24 Stunden nach der Injektion an tritt die Gef?sserweiterung in den Hintergrund und die Faseranschwellung wird wieder deutlich, was 48 Stunden nach der Injektion sein Maximun erreicht. In der Unterkieferdr?se vermindern sich die gr?bere K?rnchen der Dunkelzellen bald nach der Injektion und von der 1 Stunde nach der Injektion an zeigen die Netzmaschen in den Hellenzellen verschiedene Gr?sse nach und nach, wobei die Dunkelzellen selbst sich verkleinern, w?hrend die Hellenzellen eine Anschwellun zeigen, was 12 Stunden nach der Injektion am deutlichsten zu sehen ist. In der Parotis werden die Granula der Dr?senzellen direkt nach der Injektion gr?ber und erf?llen den ganzen Zellleib 12 Stunden sp?ter. Jedoch an der 24 Stunde nach der Injektion verschwinden sie g?nzlich und machen feinen K?rnchen Platz, wobei die Zelle sich verkleinert. In der Leber schwellen die meisten Leberzellen unmittelbar nach der Injektion an, aber 20 Minuten sp?ter werden sie durch die erweiterten Blutkapillaren gedr?ckt und verkleinert. Die Zellen behalten diesen Zustand eine Zeitlang, nur dass ihre Kerne eine Anschwellung zeigen. Nach 12 Stunden tritt die Erweiterung der Kapillaren zur?ck und die Leberzellen quellen wieder auf, indem sie sich dicht ber?hren. In der Niere fangen die Blutkapillaren unmittelbar nach der Injektion sich zu erweitern an, und die Harnkan?lchen werden eine Zeitlang gedr?ckt. Besonders zeigt der Glomerulus eine lange Zeit die Anschwellung. Von der 1 Stunde nach der Injektion an erweist das Harnkan?lchen durch seine ganze L?nge eine starke Anschwellung, aber von der 24 Stunde nach der Injektion an tritt die Wiederherstellung auf, indem das Kan?lchen sich von seinem Endgebiet allm?hlich verkleinert. In der Milz erweitern sich die intranodularen Arterien, die H?lsenarterien und die Venensinus unmittelbar nach der Injektion, wobei das retikul?re Gewebe fadenartig wind und gr?ssere Maschen zeigt. Dieser Zustand dauert nur eine Kurze Zeit. Nach einer Stunde quellen die W?nde der intranodularen Arterie, der H?lsenarterie, sowie das retikul?re Gewebe auf, was nach 6 Stunden in die Augen springt, indem die F?den des Retikulms miteinander verschmelzen und eine solide Masse bilden, w?hrend die intranodularen Arterien und die H?lsenarterien eine verdickte Wand und ein schmales Lumen zeigen. Dabei enth?lt der Milzsinus nur die Lymphozyten, verliert fast alle Erythrozyten, die aber den Venensinus erf?llt. Dieser Zustand ist 48 Stunden nach der Injektion am deutlichsten. Die genannte Anschwellung der Arterienwand und des retikul?ren Gewebes tr?gt zur Verhinderung des Blutstromes in der Milz bei. 3) Wenn man die Milzarterie oder die Milzvene unterbindet oder darauffolgend Amylnitrit injiziert, so tritt stets keine Erweiterung der milzgef?sse auf, sondern man sieht eine Anschwellung der Gef?sswand und des retikul?ren Gewebes. Diese Tatsache ist darauf zuruckzuf?hren, dass Amylnitrit in allen diesen F?llen in die Milz nicht hineintritt. Dasselbe gilt auch f?r den Fall der Venenunterbindung, denn in diesem Falle Blutstaung verhindert das Eintreten des Amylnitrites in die Milz selbst, wenn es injiziert wird. Auf Grund der genannten Tatsache ist der Verfasser der Meinung, dass die gef?sserweiternde Wirkung des Amylnitrites keine zentrale, sondern eine Peripherische ist. 4) Durch Einf?hrung des Amylnitrites in den Tierk?rper wird der peripherische Parasympathicus in erster Linie erregt, was die Gef?sserweiterung f?r Folge hat. Dann quellen die Zellen verschieder Organe auf, wobei die Speichelsekretion bef?rdert wird. In gewissen Organen zeigt die Blutgef?sswand eine starke Verdickung, die das Gef?sslumen betr?chtlich verengert. en-copyright= kn-copyright= en-aut-name=TakemotoIwao en-aut-sei=Takemoto en-aut-mei=Iwao kn-aut-name=竹本巖 kn-aut-sei=竹本 kn-aut-mei=巖 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學解剖學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1217 end-page=1242 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber den Einfluss des Kupfers auf die Gallensteinbildung kn-title=銅ノ膽石形成ニ及ボス影響ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Ich habe neuerdings in einigen forschungsberichten gelesen, dasz eine betr?chtliche Menge Kupfer im Gallenstein enthalten ist und dasz, wenn man verschiedenen Tieren Kupfer per os einzunehmen gebt, bei ihnen der Gallenstein sich bildet. Jedoch habe ich noch keine genauere Untersuchung der Beziehung zwischen Kalzium (ein wichtiger Gallensteinbestandteil) und Kupfer gefunden, wenn das auch immer zur Unzul?nglichkeit meiner Kenntnis zur?ckzuf?hren sein mag. Deshalb habe ich die M?glichkeit der Gallensteinbildung untersucht, indem ich in der hypercalc?mischen und anderen verschiedenen Perioden gesunden H?nden Kupfer gegeben. Ich k?nne so aus meinen Experimenten schlieszen, dasz das Kupfer einen gewissen Einflusz auf die Gallensteinbildung aus?be. Ich bin nun davon ?berzeugt, dasz das Resultat meiner Arbeit einmal zur Neuheit unserer Wissenschaft geh?ren wird. en-copyright= kn-copyright= en-aut-name=TsurumiTakao en-aut-sei=Tsurumi en-aut-mei=Takao kn-aut-name=鶴身孝雄 kn-aut-sei=鶴身 kn-aut-mei=孝雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學石山外科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1243 end-page=1269 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Serologische Studien ?ber mit Formalin vorbehandelte rote Blutk?rperchen und Serum (II. Mitteilung.) ?ber den Einfluss des Formalin auf die Antigenit?t der roten Blutk?rperchen kn-title=血球竝ニ血清ニ及ボス「フオルマリン」ノ影響ニ就テ(第2報)血球抗原性ニ及ボス「フオルマリン」ノ影響ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=In der ersten Mitteilung habe ich haupts?chlich den direkten Formalin-einfluss auf die roten Blutk?rperchen in bezug auf die Resistenz?nderung behandelt. Hier will ich in diesem Teil die Antigenit?t der mit Formalin vorbehandelten roten als Antigene sowohl zur Reaktion als auch zur Antik?rperbildung ber?hren. Zweitens will ich ?ber die Komplementbindung zwischen vorbehandelten Roten und H?molysinen handeln, weil stark formalisierte Rote bei der H?molysinwirkung unver?ndert bleiben. 1) Die Bindung zwischen H?molysin oder H?moagglutinin und 10% Formol-fixierten roten Blutk?rperchen ist schw?cher als die mit unbehandelten Erythrocyten, doch kann man durch Immunisierung mit Formol-fixierten Roten H?molysine oder H?moagglutinine bei Kaninchen erzeugen. 2) Auf 10% Formol-fixierte rote Blutk?rperchen reagieren die H?molysine ganz negativ bei Anwesenheit des Komplementes, bei der Agglutination sieht man jedoch eine, wenn auch sehr schwache Reaktion. 3) 10% Formol-fixierte rote Blutk?rperchen absorbiert das H?molysin, besonders der damit gebildete Antik?rper, welcher bei der H?molysinwirkung ganz intakt bleibt. Man kann daher bei diesem Versuch durch die Formalin-wirkung auf die Zustandsspezifit?t schliessen. 4) 10% Formol-fixierte rote Blutk?rperchen habe ich in folgender Weise als Antigene f?r die Komplementbindungsreaktion verwandt; Ich liess 10% Formol-fixierte rote Blutk?rperchen Emulsion, Komplement und H?molysine, bei 37°C. 1 Stunde lang stehen und nahm nach der Zentrifugierung die Abgusse vor. Zu diesen Abg?ssen f?gte ich wieder ein h?molytisches System und digerierte bei 37°C. 2 Stunden lang. Nach dieser Behandlung konnte ich die Reaktion wie bei der gew?hnlichen Komplementbindung beurteilen. Die Formol-fixierten roten Blutk?rperchen von 5%iger Emulsion brechen sich mit dem Komplement bei Anwesenheit des entsprechenden Antigens (H?molysin) am st?rksten. Der Titer der Komplementbindung steht etwas niedriger (zirca 1/4) als der H?molysintiter bei dem gleichen Immumserum. 5) Mit 10% Formol-fixierten Stroma kann man auch bei Kaninchenimmunisierung H?molysin und H?moagglutinin erzeugen. en-copyright= kn-copyright= en-aut-name=KoizumiMichinori en-aut-sei=Koizumi en-aut-mei=Michinori kn-aut-name=小泉道徳 kn-aut-sei=小泉 kn-aut-mei=道徳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學衛生學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1270 end-page=1286 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Klinische Beobachtungen der Pankreasfunktion bei verschiedenen Pankreaskrankheiten kn-title=各種膵臟疾患ニ於ケル膵機能ノ臨牀的觀察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Fr?her habe ich schon festgestellt, dass die Zuckertoleranz bei einem gesunden Hunde 0.2 Gramm 40%ige Traubenzuckerl?sung f?r jedes eine Kilogramm von dessen K?rpergewicht ist. Noch weiter habe ich, indem ich ihn dann mit verschiedenen Mengen des Traubenzuckers parenteral belastet, solches gefunden dasz sich die Pankreasfunktion am deutlichsten zeigt, wenn man es in der Zuckertoleranz tut. Sodann habe ich einerseits mittels dieser parenteralen Zuckerbelastungsprobe Ver?nderungen der Zuckerassimilation bei dem Hunde mit dem partiell exstirpierten Pankreas oder mit der experimentellen Pankreasneklose geforscht und andererseits die Funktion des Pankreas beobachtet. Um diese ergebnisse zur klinischen Diagnose anzuwenden, habe ich weiter eine andere Probe angestellt, indem ich einigen Kranken mit akutem, chronischem Pankreatitis oder mit Pankreaskrebs die der Toleranz nahe liegende Menge des Zuckers (0.2 Gramm 40%ige Trauben zuckerl?sung f?r jedes eine Kilogramm des K?rpergewichts) gegeben. Dabei habe ich gefunden, dasz das Pankreatitis eine besondere Belastungskurve hat und dasz diese Kurve, wenn man sie zur Differentialdiagnose anwendet, ganz nutzbar ist. ?brigens bin ich auch zu einem interessanten Resultat gekommen, als ich diese Methode w?hrend der Anfangszeit des Pankreaskrebses gebraucht. Die sog. parenterale Zuckertoleranzbelastungsprobe kann also als eine nutzbare Methode gelten, um die Krankheiten des Pankreas zu untersuchen. en-copyright= kn-copyright= en-aut-name=ItamiMasao en-aut-sei=Itami en-aut-mei=Masao kn-aut-name=伊丹正雄 kn-aut-sei=伊丹 kn-aut-mei=正雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學石山外科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1287 end-page=1336 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber den Morphologischeentwicklung und den mikroskopische Beobachtungen des Chordadorsalis (I. Mitteilung.) ?ber die V?geln, besonders bei den Embryonen von Anas domestica kn-title=鳥類脊索(Chordadorsalis)ノ形態學的發生竝ニ組織學的研究(第1報)家鴨ニ於ケル觀察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Der Verfasser hat bei morphologischen Studien ?ber die Bildung der Chorda dorsalis dei dem Entenkeimlinge und durch die Feststellungen bei den mikroskopischen Beobachtungen die folgenden Resultate gewinnen und ver?ffentlichen k?nnen. 1) Die Chorda dorsalis des Entenkeimlings, von dessen Urwirbeln nur einer 24 Stunden nach dem Beginn des Br?tens erst gez?hlt wird, beginnt auf der Stelle der 280μ vom Scheitel des Embryos von der Vertiefung der Bauchwand, der Mittelrinne vor dem Gehirn zur Oralseite nur ein kleines St?ck des Scheitels zeigend. Die wagrecht geschnittene Fl?che der Chorda dorsalis in diesem Stadium ist eigentlich ein aus 5-8 Zellen entstehender Zellenstrang. Diese betreffenden Zellen sind im allgemeinen etwa w?rfelf?rmig, aber einige darunter sind rund oder schiefrund; abgesehen davon sind alle gleichartig reich an Protoplasmen. Es ist gesehen nat?rlich, dass das Chordagewebe aus den Mesodermzellen trennen. 2) Die normale Gestalt der Chorda dorsalis bildet binnen 40 Stunden die Zahl der Urwirbel, die auf f?nf beschr?nkt ist, im allgemeinen die schiefrundliche Stange, im besonderen aber die rundliche, und darauf folgt die Verwandlung, dass die mitte der Chorda dorsalis zur rundlichen Stange umgestaltet wird und die beiden Oral und Kaudalseiten schiefrund ausgedehnt werden. Die mit den 42 Stunden des Br?tens verlaufenen acht Urwirbeln schon ?ber den Embryo hinauswachsende Chorda dorsalis bildet mit Ausnahme eines kleinen Teils derselben in ihrer ganzen L?nge eine rundliche Stange und zugleich zeigen die peripheren Durchmesser der Chorda dorsalis an deren Oral und Kaudalseite in ihrer Gr?sse nur einen kleinen Unterschied. W?hrend beim Embryo mit der in 60 Stunden entstehenden Urwirdelzahl 21-23 der periphere Durchmesser des Nervenrohrs kaudalw?rts nach und nach abnimmt, kann der Durchmesser der Chorda dorsalis in ihrer ganzen L?nge ungef?hr gleich bestimmt werden. 3) Die schwach entwickelten Chorda, dorsalis Zellen haben keine Koalitionskraft, sind isoliert und dabei findet soger die mitotische Zellteilung ?berm?ssigerweise statt, und die Entstehung der von der Verdickung der festen Zellenbasis veranlassten Membrana limitans propria wird im Verlauf von 38 Stunden nach dem Beginn des Br?tens im Embryo bemerkt. 4) Was das Verh?ltnis der Entfernung zwischen der Chorda dorsalis, der Neuralplatte (Neuralrinne, Neuralrohr), der Bauchwand-zusammen mit (N) bezeichnet-und dem Mesoderm (Vorderdarm)-mit (D) bezeichnet-betrifft, so sind dei der Chorda dorsalis im Stadium der 38. Stunde des Br?tens d. h. bis zum Embryo mit den vier Urwirbeln N und D jedweder an der Bauchseite und R?ckseite der Chorda dorsalis angef?gt, aber je nach dem Anwachsen des Keimlings trennen sich N und D von der Chorda dorsalis, jedoch ist der Grad der Trennung bei N nicht so auffallend wie bei D zur Zeit der Erscheinung der Arteria dorsalis. In der 60 Stunde des Br?tens f?gen sich Chorda dorsalis und N nur mit Ausnahme von einem Teil der Oralseite von Anfang bis Ende aneinander und laufen zusammen. 5) Die zwischen einer Reihe Zellen auf der Bauchseite der Chorda dorsalis und dem Urdarmdach allein stehende Hypochorda ist beim Embryo im Stadium der drei Urwirdel zu sehen. 6) Die Evolution der Chorda-Scheide als homogenes Gewebe in der Peripherie der Membrana limitans propria ist zuerst beim Embryo der f?nfzehnz?hligen Urwirbel zu sehen, und dann beim allm?hlich sich vervollkommenden Embryo dehnt sie sich nach den beiden Richtungen der Oralseite und Kaudalseite aus und auch dabei ist sie sehr deutlich zu sehen. Die bis zum Embryo mit den 23 Urwirbeln sichtbare Chorda-Scheide entspricht meiner Aussicht nach der vom Herrn Kuhlenbeck genannten "plasmatischen, fibrill?ren Membran". 7) Die Bildung des Ceutralcanals geschieht im Embryo mit achtz?hligen Urwirbeln in der 42. Stunde des Br?tens und Je nach der langsamen Vermehrung der Urwirbelzahl, verl?ngert sick auch allm?hlich die Achse des Kauals. Beim Embryo mit den 20 Urwirbeln erreicht die L?ngsrichtung 50-80μ. 8) In dem Oralgebiet oder dem Kaudalgebiet der Chorda dorsalis n?hern sich die Plasmadesmen vom Mesoderm zum Rande der Chorda dorsalis, und die Plasmastreifen gehen getrennterweise auseinauder und finden ihren Ablauf in die organisation der Chorda dorsalis. Diese Erscheinung ist Haupts?chlich in einem schlecht entwickelten Embryo zu finden. 9) Der Gipfel der Chorda dorsalis beginnt beim Embryo erst in dor 40. Stunde des Brutens sich vorzubeugen. 10) Keilf?rmige Zellen, welche sich der L?ngsrichtung der Chorda dorsalis gegen?ber geldrollenartig und regelm?ssig anreihen, vereinigen sich aber unregerm?ssig miteinauder am Ende ihrer inneren Seite. 11) Der Teil, wo die Differenzierung in der Chorda dorsalis am h?chsten ist, entspricht dem Wanderungsteil des Rhombencephalons und R?ckenmarks ; die oral und Kaudalseiten bleiben immer am unentwickelsten. 12) Die Verlagerungsachse der Chromosomen der R?ckenstrangszellen zur R?ckenstrangsachse scheint, wie Herr Kuhlenbeck behauptet, zu den Folgenden drei Hauptrichtungen zugeleitet zu werden, d. h. a. Tangentiale Richtung. b. Parallele Richtung. c. Senkrechte Richtung. 13) Sobald sich die Chorda dorsalis der Nervenrinnen wand n?hert, sinkt die spissige Kante herunter und bildet sich, als ob sie den R?ckenstrang im Empfang n?hme. 14) Wenn auch sich die Kaudalw?rts organisierten R?ckenstrangszellen mit den sich im peripheren Organ befinden und auch organisierten vermischen, (oder mit den das periphere Organ organisierenden Zellen), die R?ckenstrangsbildung abbauen und verwirrend verschwinden, findet dies doch am sp?testen statt, dass sie mit dem Entoderm in Kongrezation geraten. 15) In der 60. Stunde des Br?tens ist die Vacuolisierung noch nicht zu bemerken, dagegen sind die nach meiner Benennung sogenannten "der H?hlenbildung und Wanderung f?higen Zellen" hie und da zerstreut zu beobachten. en-copyright= kn-copyright= en-aut-name=MizunoBunjiro en-aut-sei=Mizuno en-aut-mei=Bunjiro kn-aut-name=水野文次郎 kn-aut-sei=水野 kn-aut-mei=文次郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學解剖學教室胎生學研究室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1337 end-page=1341 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber zwei F?lle von Rippengumma kn-title=肋骨護謨腫ノ2治驗例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Neuerdings beobachte der Verfasser zwei seltene F?lle von Rippengumma, welche als Rippencaries diagnostiziert und zuerst durch die Rippenresektion u. nach der Rezidiv durch die antiluetische Behandlung ausgeheilt sind. Der erste Fall war ein 35 j?hriger Barbier, der als Rippencaries diagnostiziert u. durch die Rippenresektion tempor?r geheilt ist, aber bald nachher bekam er Rezidev, dann perforierte der Local; so probierte Wassermannsche Reaktion, welche positiv reagierte. Der Patient wurde antiluetisch behandelt u. nach 45 Tagen geheilt ist. Der zweite Fall war ein 31 j?hriger Kaufmann, welcher von Anfang an als Rippengumma diagnostiziert durch Wa R. und denn durch die Rippenresektion u. antiluetische Kur ausgeheilt ist. Die Differentialdiagnose zwischen Rippencaries und Rippengumma ist f?r den Arzt ambulatorisch schwierige Aufgabe. Bei der Rippenerkrankung erinnert man zuerst gew?hnlich an Rippencaries, man trifft aber manchmal dem Rippengumma, obwohl es so selten ist. So soll man sich auch an Rippengumma erinnern, wenn der Verlauf als Tuberculose etwas anders ist. Dazu Wa R. oder R?ntgenphotographie als Hilfsdiagnostik sehr wichtig. Aber man kann durch probe antiluetische Kur die Diagnose klar zu stellen. en-copyright= kn-copyright= en-aut-name=UkitaKatsuzo en-aut-sei=Ukita en-aut-mei=Katsuzo kn-aut-name=浮田勝造 kn-aut-sei=浮田 kn-aut-mei=勝造 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學石山外科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1350 end-page=1365 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Statistische Betrachtung ?ber 200 Radikaloperationen der Hernienf?lle kn-title=「ヘルニア」根治手術200例ノ統計的觀察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Die Statistik von 200 Bruchf?llen, die w?hrend 9 Jahre in unserem Institut der Radikaloperation unterworfen sind, zeigt folgende Resultate. 1) Die Morbidit?t des m?nnlichen und des weiblichen Geschlechtes: M?nner betragen 168, d. h. 8.4%, Frauen 32 d. h. 16%. Die Morbidit?t der linken und der rechten Seite: Rechte 132 d. h. 66%, linke 55 d. h. 27,5%. Radikal operierte Kranke von beiderseitigen Hernien 8. Unter 179 Leistenbruchkranken sind M?nner 163, Frauen 16. 2) Die Vergleichung der Erkrankungsalter des Leistenbruchs zeigt, dass der letztere im S?uglingsalter am meisten auftritt, dann allm?hlich abnimmt, aber im Junglingsalter sowie im Klimakterium zuzunehmen scheint. 3) Die postoperative Sterblichkeit zeigt 2,5% d. h. 5. Von diesen ist einer Patient von angeborenem Nabelbruch, alle andere sind nur solche Kranken, bei denen es durch Einklemmung zum Darmbrand kam und der Darm reseziert wurde. Keiner mit Hodensackbruch starb, w?hrend die Sterblichkeit der Leistenbruchkranken 8% und die der Schenkelbruchkranken 28,5% zeigte. Das r?hrt daher, dass die Geschwulst des Schenkelbruchs klein ist, so dass man sie oft erst dann bemerkt, nachdem die Einklemmung schon eingetreten ist. Das beruht auch darauf, dass er mit anderer akuten Bauchh?hlenerkrankung verwechselt werden kann, weil er sehr leicht den Darmwandbruch veranlasst. 4) In bezug auf das Alter bei der Radikaloperation befindet sich die Operationsh?ufigkeit der kleinen Kinder in der Neigung zur Vermehrung. 5) 51,8% von Bruchinhalt ist Darmst?ck und 45% Grossnetz, also diese beiden nehmen den gr?ssten Teil der s?mtlichen F?lle. Im ?brigen besteht der Inhalt bei 1 Fall aus Leber, bei 5 aus Hoden, bei 1 aus Eileiter und 13 sind von Hydrocele begleitet. 6) Die Fernergebnisse zeigen bei 150 untersuchten Kranken 0, 7% Rezidiv d. h. das von einem innere Leistenbruchfall. 7) Als Methode zur Radikaloperation benutzt man bein Erwachsenen vorwiegend Bassinis Verfahren, beim kleinen Kind sowie S?ugling Lucas Champoni?res-Methode. 8) Man gebraucht Seide als Nahtfaden. Catgut ruft eine gr?ssere Rezidiv-h?ufigkeit hervor. 9) Da der k?rperliche Arbeiter mehr zum Rezidiv neigt, so ist es n?tig, dass er sich wenigstens 3 Wochen lang nach der Operation ruhig h?lt. Sein Aufenthalt im Hospital soll 2 Wochen sein. en-copyright= kn-copyright= en-aut-name=HiraideShozo en-aut-sei=Hiraide en-aut-mei=Shozo kn-aut-name=平井出正三 kn-aut-sei=平井出 kn-aut-mei=正三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=4 article-no= start-page=1269 end-page=1274 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of OX Substance of DNA Content and Mitotic Phase of Subcutaneously-Transplanted Yoshida Sarcoma Cells kn-title=皮下移植吉田腫瘍細胞のDNA量及びMitotic phaseに対するOX物質の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=After transplanting Yoshida sarcoma cells under the skin of the thigh of hybrid mice, the author injected 0.2cc of 2% unsaturated fatty acid fraction (denominated as OX substance) intramuscularly and observed the changes in the histological picture, in the mitotic phase as well as the changes in the quantity of DNA per cell, along with the lapse of time, and obtained the following results. 1. The histological pictures revealed the phenomena such as an increase in necrotic foci, a general diminution in stainability and indistinct cell boundary. 2. In counting the number of those cells with a relatively strong activity in cancer foci at various mitotic phases, it has been found that from 6 to 12 hours after the OX injection the number of the cells in metaphase is decreased and from 24 hours on the number of such cells approaches the normal. 3. In the estimation of DNA content per cell, from 6 to 12 hours after the OX injection the number of the cells undergoing a relatively active proliferation but with a decreased DNA content tends to increase but after 24 hours the content per cell approaches the normal level. en-copyright= kn-copyright= en-aut-name=IguchiYoshiko en-aut-sei=Iguchi en-aut-mei=Yoshiko kn-aut-name=井口与志子 kn-aut-sei=井口 kn-aut-mei=与志子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1366 end-page=1374 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Statistische Betrachtung des Schenkelbruchs kn-title=股「ヘルニア」ノ統計的觀察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Unter 200 Bruchkranken, die w?hrend 9 Jahre in unserem Institut der Radikaloperation unterzogen wurden, betragen Schenkelbruchkranke 16, also 8% von ihuen, einen relativ hohen Prozentsatz. Die Sterblichkeit der Schenkelbruchkranken bel?uft sich auf 28,5%, also 2 von 16, w?hrend die im ganzen 2,5% ist. Nachdem ich untersucht hatte, warum ihre Sterblichkeit so gross ist, und zugleich eine statistische Betrachtung angestellt hatte, bin ich zu folgenden Schl?ssen gelangt. Der Schenkelbruch tritt ?fters bei Frauen im postklimakterischen Alter auf und kommt h?ufig rechterseits zustande wie Leistenbruch. Da seine Einklemmungsh?ufigkeit im Verh?ltnis zu anderen Hernien hoch, seine Geschwulst klein ist, indem die grosse Mehrzahl der Kranken den Darmst?ck zum Inhalt macht und zwar h?ufig die Darmwandhernie hervoruft, die eine erhebliche Sterblichkeit zeigt und nur wenige Hoffnung auf Naturheilung zul?sst, so ist es ?usserst erforderlich, dass man m?glichst fr?h nach der Entdeckung seine Radikaloperation vornimmt. Auf diese Weise k?nnte man seine Einklemmungsh?ufigkeit sowie Sterblichkeit vermindern. Der Schenkelbruch macht nicht so komplizierte Operationsarten notwendig, weil seine postoperative Rezidivh?ufigkeit relativ gering ist. Es kommt nur darauf an, dass man den Bruchsack am Halsteil in einer m?glichst hohen Lage vollst?ndig exstirpiert. Was den Schenkelring betrifft, so gen?gt es, ihn mittels der einfachen Methode zu verschliessen. Bei der Operation der eingeklemmten Schenkelhernie, besonders solcher mit dem Inhalt des Darmst?cks sei man beim Schnitt des Bruchsacks, besonders seines Halsteils, am vorsichtigsten, da in diesem Fall die Darmwand durch Ausstreckung sehr verd?nnt und ?usserst verletzbar ist. en-copyright= kn-copyright= en-aut-name=HiraideShozo en-aut-sei=Hiraide en-aut-mei=Shozo kn-aut-name=平井出正三 kn-aut-sei=平井出 kn-aut-mei=正三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=743 end-page=746 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Primary Reticulum Cell Sarcoma of the Stomach; Report of a Case kn-title=胃細網肉腫症の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A case of primary reticulum cell sarcoma of the stomach was reported. The patient was a fifty-four year old housewife, with the chief complaints of epigastric pain and anorexia. The roentgen manifestations were consistent with gastric cancer, and total gastrectomy was performed. The lesion was localized in the stomach and histological examination revealed reticulum cell sarcoma. en-copyright= kn-copyright= en-aut-name=ShiakuTakeru en-aut-sei=Shiaku en-aut-mei=Takeru kn-aut-name=塩飽健 kn-aut-sei=塩飽 kn-aut-mei=健 aut-affil-num=1 ORCID= en-aut-name=OginoKeichiro en-aut-sei=Ogino en-aut-mei=Keichiro kn-aut-name=荻野敬一郎 kn-aut-sei=荻野 kn-aut-mei=敬一郎 aut-affil-num=2 ORCID= en-aut-name=AonoKaname en-aut-sei=Aono en-aut-mei=Kaname kn-aut-name=青野要 kn-aut-sei=青野 kn-aut-mei=要 aut-affil-num=3 ORCID= en-aut-name=HadaYoshihiro en-aut-sei=Hada en-aut-mei=Yoshihiro kn-aut-name=羽田良洋 kn-aut-sei=羽田 kn-aut-mei=良洋 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1293 end-page=1298 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Free Amino Acids in the Brains ? The Influence of Thyroidectomy on the Free Amino Acids and Related Compounds in the Brain of Rat kn-title=脳の遊離アミノ酸について(?)甲状腺剔除の脳遊離アミノ酸およびその関連物質におよぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=With the purpose to study the influence of thyroidectomy on the free amino acids and the related compounds the author performed the assay of 11 of these substances by ion exchange column chromatography, using the rat brains as the material. As the result it has been found that aspartic acid, glutamic acid, alanine, serine, N-acetylasparticacid, and glycerophosphoethanolamine, the substances that were decreased in the brains of hypophysectomized animals, have been maintained at the normal level on thyroidectomy. en-copyright= kn-copyright= en-aut-name=NishiokaHirosuke en-aut-sei=Nishioka en-aut-mei=Hirosuke kn-aut-name=西岡博輔 kn-aut-sei=西岡 kn-aut-mei=博輔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=747 end-page=762 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Leukemoid Reaction in Mouse Induced by MY Sarcom Transplantation Part T. Studies on the tissue culture of bone marrow and spleen kn-title=MY肉腫移植による実験的類白血病反応に関する研究 第1編 骨髄並びに脾組織培養 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Hematological and histological investigations were performed in mice with myelogenous type of leukemoid reaction induced by transplantation of MY sarcom. Thereafter, tissue culture of bone marrow and spleen were carried out. The following results were obtained. 1) Tissue culture of bone marrow. The growth patterns in bone marrow culture were always normal and did not display the leukemic type throughout the entire course of leukemoid reaction. The growth ratio of the pattern increased as leukemoid reaction progressed, while the cell density was fairly constant through the course of leukemoid reaction. Wandering velocity of the neutrophils was low in the early and intermediate stages and did not show difference from the controls in the advanced stage. Cytological observations by phase contrast microscopy, vital staining and fluorescence microscopy did not revealed any difference from normal marrow cells, nor atypism which was usually seen in leukemic cells. 2) Tissue culture of spleen. The normal pattern was always observed as seen in bone marrow tissue culture through the entire course of leukemoid reaction. The growth ratio increased as the reaction progressed. However, the cell density did not show difference from the controls. In leukemoid reaction, the lymphocytic cells were gradtally replaced by the neutrophilic cells. Therefore, 70 to 80 % of the cells in the growth zone of the splenic tissue culture were occupied by neutrophilic cells. In fluorescence tissue culture, the growth zone seen in leukemoid reaction displayed diffuse reddish orange color as a result of a large number of neutrophilic cells present, while the zone observed in controls showed diffuse yellowish green color owing to abundant lymphocytes. These findings were very helpful for differentiation of the splenic tissue in leukemoid reaction from the controls. The findings described above seemed to demonstrate the development of extramedullary hematopoiesis in the spleen. en-copyright= kn-copyright= en-aut-name=KaharaMasanori en-aut-sei=Kahara en-aut-mei=Masanori kn-aut-name=加原雅教 kn-aut-sei=加原 kn-aut-mei=雅教 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学平木内科 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1375 end-page=1387 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Vergleichende Studien ?ber die St?rke der Wirkung einiger neuer adrenalinverwandter Stoffe auf die f?rderuden und hemmenden Fasern des Sympathicus (I. Mitteilung): Versuche am ?berlebenden Kaninchendarm, Rattenuterus, Bronchialmuskel des Rindes, Detrusor und Trigonum der Kaninchenblase und am normalen und schwangeren Kaninchenuterus kn-title=2-3新「アドレナリン」類似體ノ催進及ビ抑制性交感神經纖維ニ對スル作用強度比較研究(第1報)家兎腸管,白鼠子宮,牛氣管支筋,家兎膀胱利尿筋及ビ三角部筋,家兎正常竝ニ妊娠子宮ニ對スル作用比較 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Um einige neue adrenalinverwandte K?rper, Aminoacetobrenzkatechin, Sympatol und Ephetonal, in ihrer Wirkung zu vergleichen, wurden Versuche an verschiedenen ausgeschnittenen glattmuskeligen Organen, wie Kaninchendarm, Rattenuterus, Bronchialmuskel des Rindes, Detrusor und Trigonum der Kaninchenblase und am normalen und schwangeren Kaninchenuterus angestellt. An diesen Organen zeigen diese 3 Stoffe eine fast reine Wirkung auf die sympathischen Nervenfasern, mit der Ausnahme, dass Sympatol und Ephetonal am Kaninchenuterus teilweise den Muskel anzugreifen scheinen. Am Kaninchendarm, Rattenuterus, Bronchialmuskel des Rindes und Detrusor des Kaninchens wirken diese 3 Gifte durch Reizung der hemmenden Fasern immer bemmend. Am Trigonum vesicae wirken sie in kleinen Konzentrationen durch Reizung der hemmenden Fasern hemmend und in h?heren Konzentrationen (mit Ausnahme von Ephetonal) durch Reizung der f?rdernden anregend. Am Kaninchenuterus wird ebenfalls bei allen Stoffen eine erregende Wirkung konstatiert. Die Wirkunsst?rke der 3 Stoffe auf die hemmenden Fasern schwankt zwar je nach den Organarten ziemlich, im allgemeinen aber ist Aminoacetobrenzkatechin am st?rksten, w?hrend Sympatol und Ephetonal sich nahestehen, beim Kaninchendarm jedoch ist Sympatol dem Ephetonal in der Wirkung weit ?berlegen. In der erregenden Wirkung am Trigonum und Kaninchenuterus ist auch Aminoacetobrenzkatechin am st?rksten, dann folgt Sympatol, und Ephetonal ist am schw?chsten. Am Trigonum wird sogar nach Ephetonal keine erregende Wirkung nachgewiesen. Es gibt sich also, dass diese 3 Stoffe ?hnliche Wirkungstypen haben, sodass die St?rke der hemmenden und f?rdernden Wirkung bei diesen 3 Stoffe etwa parallel geht. Im allgemeinen scheinen diese 3 Stoffe, wie Adrenalon und Ephedrin, eine besonders starke Wirkung auf die hemmenden Fasern des Sympathicus auszu?ben. en-copyright= kn-copyright= en-aut-name=TachibanaKatsuo en-aut-sei=Tachibana en-aut-mei=Katsuo kn-aut-name=橘捷夫 kn-aut-sei=橘 kn-aut-mei=捷夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學藥理學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1299 end-page=1306 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Free Amino Acids in the Brains XIII A Study on the Free Amino Acids in Various Parts of Human Brain kn-title=脳の遊離アミノ酸について(XIII) ヒト脳各部位の遊離アミノ酸およびその関連物質 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By means of ion exchange column chromatography the author carried out quantitative analyses of 14 kinds of free amino acids including the related compounds using the brain of the person who died of acute loss of blood. The parts of the brain used for the analysis were frontal cortex, corpus callosum, caudate nucleus, globus pallidus, thalamus, hypothalamus and medulla oblongata. The results are as follows. 1. In corpus callosum which contains little cellular components extremely minute quantities of phosphoethanolamine, aspartic acid, glutamic acid and γ-aminobutyric acid could be detected. 2. In globus pallidus a surprisingly large quantity of γ-aminobutyric acid could be found and it was far greater than that contained in hypothalamus. 3. In medulla oblongata only small quantities of phosphoethanolamine, aspartic acid, and glutamic acid could be detected. Likewise γ-aminobutyric acid was found not so abundant. This seems to be due to the fact that the present experiment was conducted with medulla oblongata including white matter. 4. Although only in a small quantity, cystathionine could be assayed in all these parts except globus pallidus and thalamus. 5. Even from the comparative biochemistry the present quantitative analyses gave an interesting contrast to the values obtainable in the brains of lower animals. 6. Although it was difficult to recognize any distinct difference in the pattern of amino acids between the adult brain and the infant brain, there was a clear-cut difference in the amino acid pattern of the adult brain and that of the fetal brain. Namely, in the adult human brain there exist far greater quantities of aspartic acid, glutamic acid, γ-aminobutyrie acid, and N-acetylaspartic acid than those in the fetal brain and conversely far less quantities of phosphoethanolamine and taurine than in the latter. Likewise tyrosine detected in the fetal brain could not be recognized in the adult human brain. en-copyright= kn-copyright= en-aut-name=NishiokaHirosuke en-aut-sei=Nishioka en-aut-mei=Hirosuke kn-aut-name=西岡博輔 kn-aut-sei=西岡 kn-aut-mei=博輔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1388 end-page=1420 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Wechselbeziehung zwischen der Schilddr?se und der Milz (I. Mitteilung.) Forschungen ?ber junge Erythrozyten, insbesondere reticulierte Erythrozyten und ?ber die Senkungsgeschwindigkeit der Erythrozyten kn-title=甲状腺ト脾臟トノ相互關係(第1報)幼若赤血球殊ニ網状赤血球及ビ赤血球沈降速度ニ關スル研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Neuerdings sind viele Arbeiten erschienen, in denen man sich mit der Erforschung der Wechselbeziehung zwischen der Schilddr?se und der Milz bei der blutbildenden Funktion des Knochenmarks besch?ftigt. Herr Sakai hat auch neulich gefolgert, dasz die unscharfe Zone bei der Sedimentierung der Erythrozyten aus reticulierten Erythrozyten bestehe und ein biologisches Ph?nomen sei, das die Steigerung der Erythrop?se im Knochenmark andeute. Infolgedessen habe ich nun untersucht, welche Einfl?sse die Schilddr?se und die Milz auf die Zahl der Erythrozyten, die Menge des H?moglobins, auf junge Erythrozyten, besonders reticulierte Erythrozyten, und auf die Senkungsgeschwindigkeit der Erythrozyten aus?ben, und weiter, welche Beziehungen zwischen den reticulierten Erythrozyten, der unscharfen Zone und der blutbildenden Funktion des Knochenmarks bestehen. Ich habe dabei Kaninchen als Versuchstiere ben?tzt, und zwar unter manchen verschiedenen Bedingungen. Ich habe z. B. bei dem einen Kaninchen die Milz, bei einem anderen die Schilddr?se, oder bei einem dritten die Schilddr?se und dann das erste mit der Homoiotransplantation der Schilddr?se, das zweite mit der Homoiotransplantation der Milz, mit der Injektion des Wasserextraktes des Milz usw. behandelt. Meine Untersuchungen f?hrten zu folgenden Resultaten: Abnahme der Erythrozytenzahl, Abnahme des H?moglobins, Zunahme der reticulierten Erythrozyten, Bef?rderung der Senkungsgeschwindigkeit der Erythrozyten und Auftreten der unscharfen Zone. Die obenerw?hnten Ver?nderungen der Erythrozyten sind auff?lliger bei der Exstirpation und der Homoiotransplantation der Schilddr?se als bei denen der Milz; die Injektion des Milz-wasser-extraktes zeigte eine besonders starke Wirkung. Diese Ver?nderungen bedeuten jedochkeine wesentlichen, sondern nur solche der Verh?ltnisse und werden nicht unmittelbar von der Schilddr?se und der Milz bewirkt. Daher bin ich bei diesem Versuch zu folgenden Ergebnissen gelangt: 1) Schilddr?se und Milz ?ben keine eigentliche Wirkung auf die Abnahme der Zahl der Erythrozyten und des H?moglobins, auf das Vorkommen der jungen, insbesondere der reticulierten Erythrozyten, auf die Senkungsgeschwindigkeit der Erythrozyten und das Erscheinen der unscharfen Zone aus. 2) Reticulierte Erythrozyten geh?ren zwar zu den jungen Erythrozyten, kommen jedoch unabh?ngig von der erythrop?tischen Funktion des Knochenmarks vor; es ist das also kein Anzeichen f?r eine gesteigerte erythropoetische Funktion, sondern es geschicht, wenn reticulierte Erythrozyten fr?hzeitig aus dem Knochenmark herauskommen. 3) Die unscharfe Zone und die reticulierten Erythrozyten, die man bei Sedimentierung der Erythrozyten trifft, treten bis zu einem gewissen Grade in proportionalem Verh?ltnis auf, es ist daher ein kausaler Zusammenhang zwischen den beiden anzunehmen. en-copyright= kn-copyright= en-aut-name=FujikawaTakeo en-aut-sei=Fujikawa en-aut-mei=Takeo kn-aut-name=藤河武雄 kn-aut-sei=藤河 kn-aut-mei=武雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學石山外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=7-9 article-no= start-page=763 end-page=769 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Leukemoid Reaction in the Mouse Induced by MY Sarcom Transplantation Part U. Leukemoid-reaction inducing factor kn-title=MY肉腫移植による実験的類白血病反応に関する研究 第2編 類白血病反応発現因子 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Leukemoid-reaction inducing factor was searched in mice with myelogenous type of leukemoid reaction induced by MY sarcom. The following results were obtained. 1) Leukemoid reaction was not induced by subcutaneous injection of the extract of MY sarcom. Tissue culture of bone marrow of mice injected with the extract did not show difference from the controls. Therefore, it was presumable that the extract of MY sarcom did not contain leukemoid-reaction inducing factor. 2) Serum of mice with leukemoid reaction induced by MY sarcom was demonstrated to produce hyperplasia of the bone marrow of normal mice. This seemed to indicate that serum of the mice with leukemoid reaction contained leukemoid-reaction inducing factor. en-copyright= kn-copyright= en-aut-name=KaharaMasanori en-aut-sei=Kahara en-aut-mei=Masanori kn-aut-name=加原雅教 kn-aut-sei=加原 kn-aut-mei=雅教 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学平木内科 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1421 end-page=1436 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Wechselbeziehung zwischen der Schilddr?se und der Milz (2. Mitteilung.) Forschungen ?ber die Erholung von An?mie kn-title=甲状腺ト脾臟トノ相互關係(第2報)貧血恢復ニ關スル研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Wie ich im 1. Mittilung ausgef?hrt habe, wirken Schilddr?se und Milz in Bezug auf Erythrozyten, H?moglobin, junge, besonders reticulierte Erythrozyten und bez?glich der Senkungsgeschwindigkeit der Erythrozyten, sodass sie sich nicht gegenseitig behindern. Ich habe also die Ver?nderungen der Erythrozytenzahl, der H?moglobinmenge und des Erscheinungs-prozents der reticulierten Erythrozyten untersucht, und zwar bei Kaninchen, die eine durch Aderlass hervorgerufene An?mie zeigten und daher in gesteigerter erythropoietischer T?tigkeit standen, und habe zugleich den Prozess der Erholung von dieser An?mie beobachtet, um die Wechselbeziehung zwischen der Schilddr?se und der Milz festzustellen. 1) Bei einem Kaninchen, dem die Milz exstirpiert wurde und das eine durch Aderlass hervorgerufene An?mie bekam, zeigte sich die Erholung von der An?mie gegen den Kontrollversuch bef?rdert. Reticulierte Erythrozyten kamen immer dem Grade der An?mie entsprechend vor. 2) Die Erholung von der An?mie ist nie von der Exstirpation der Schilddr?se beeinflusst worden. 3) Bei einem Kaninchen, das eine durch Aderlass hervorgerufene An?mie zeigte, dem die Milz exstirpiert war und das dann mit der t?glichen Injektion des Schilddr?senpr?parates behandelt wurde, worde die Erholung von der An?mie langsamer. 4) Ein Kaninchen, das eine durch Aderlass hervorgerufene An?mie zeigte, dem die Schilddr?se exstirpiert war, und dem t?glich ein biszchen Milzextrakt injiziert wurde, erholte sich von der An?mie langsamer. Dabei wurde auch das Vorkommen reticulierter Erythrozyten st?rker. 5) Die Schilddr?se beeinflusst die erythropoietische Funktion nicht. Die Milz hat eine die erythropoietische Funktion hindernde Wirkung. 6) Das Vorkommen reticulierter Erythrozyten bedeutet kein Anzeichen f?r eine gesteigerte erythropoietische Funktion des Knochenmarks. Bei der herabgesetzten treten sie zahlreich auf. en-copyright= kn-copyright= en-aut-name=FujikawaTakeo en-aut-sei=Fujikawa en-aut-mei=Takeo kn-aut-name=藤河武雄 kn-aut-sei=藤河 kn-aut-mei=武雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學石山外科教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1437 end-page=1448 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber eine Wertbestimmungsmethode der Antieiweissera kn-title=蛋白性沈降素血清效價ノ一測定法ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YasuharaSetutaro en-aut-sei=Yasuhara en-aut-mei=Setutaro kn-aut-name=安原節太郎 kn-aut-sei=安原 kn-aut-mei=節太郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學衛生學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=5 article-no= start-page=1450 end-page=1452 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=雜報 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山医学会 kn-aut-sei=岡山医学会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1307 end-page=1311 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Effects of OX (Uusaturated Fatty Acid Fraction From the Irradiated Rabbit Liver) on the Fertilization and Cleavage of Sea Urchin Egg kn-title=放射線照射家兎肝より抽出せる細胞毒のウニの受精及び卵割に与える影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effects of the OX substance, which was extracted from the liver of irradiated rabbits, on the sperm and egg, unfertilized and fertilized eggs of sea urchin (Hemicentrotus pulcherrimus) have been observed. 1. The sperms exposed to OX showed a decreased mortility and lost the ability to stimul to the egg to raise up fertilizing membrane suggesting the inability of giving physical shock to the egg surface or the damage of acrosome. 2. The unfertilized eggs exposed to OX retain the ability of the formation of fertiliging membrane and cleavage but showed remarkable delay in both the length of time for the membrane formation and cleavage. 3. The most sensitive effects on the fertilized eggs have been observed on the initial stage of fusion of sperm and egg nuclei and the metaphase. Immediately after the fertilization in the egg exposed to OX the fusion of sperm and egg nuclei was inhibited and in the cells on metaphase the cleavage was delayed by the prolonged period of transition from metaphase to telophase. 4. From the results with the consideration of the effects of X-rays on cleavage appearing in the past report the authors concluded the OX will be the essential substance representing the effects of X-rays on the cell cleavage. en-copyright= kn-copyright= en-aut-name=SenoSatimaru en-aut-sei=Seno en-aut-mei=Satimaru kn-aut-name=妹尾佐知丸 kn-aut-sei=妹尾 kn-aut-mei=佐知丸 aut-affil-num=1 ORCID= en-aut-name=YamamotoMichio en-aut-sei=Yamamoto en-aut-mei=Michio kn-aut-name=山本道夫 kn-aut-sei=山本 kn-aut-mei=道夫 aut-affil-num=2 ORCID= en-aut-name=UtsumiKozo en-aut-sei=Utsumi en-aut-mei=Kozo kn-aut-name=内海耕慥 kn-aut-sei=内海 kn-aut-mei=耕慥 aut-affil-num=3 ORCID= en-aut-name=ShiwakuMidori en-aut-sei=Shiwaku en-aut-mei=Midori kn-aut-name=塩飽緑 kn-aut-sei=塩飽 kn-aut-mei=緑 aut-affil-num=4 ORCID= en-aut-name=AkagiEiko en-aut-sei=Akagi en-aut-mei=Eiko kn-aut-name=赤木瑩子 kn-aut-sei=赤木 kn-aut-mei=瑩子 aut-affil-num=5 ORCID= en-aut-name=IguchiYoshiko en-aut-sei=Iguchi en-aut-mei=Yoshiko kn-aut-name=井口与志子 kn-aut-sei=井口 kn-aut-mei=与志子 aut-affil-num=6 ORCID= en-aut-name=KobayashiJunichi en-aut-sei=Kobayashi en-aut-mei=Junichi kn-aut-name=小林淳一 kn-aut-sei=小林 kn-aut-mei=淳一 aut-affil-num=7 ORCID= en-aut-name=UenoHisako en-aut-sei=Ueno en-aut-mei=Hisako kn-aut-name=上乃寿子 kn-aut-sei=上乃 kn-aut-mei=寿子 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部病理学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部病理学教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=6 article-no= start-page=1463 end-page=1472 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Klinische Erfahrungen mit Pansekal kn-title=尿道淋ニ對スル「パンセカール」ノ臨牀的價値 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verf. hat die intraven?se Injektion von Pansekal bei 20 F?llen (7 F?lle von Urethritis gonorrhoica anterior acuta, 4 F?lle von Urethritis gonorrhoica totalis acuta, 4 F?lle von Urethritis gonorrhoica subacuta totalis, 5 F?lle von Urethritis gonorrhoica chronica totalis) ausprobiert, davon bei 10 F?llen Pansekal einmal jeden Tag, bei den anderen einmal jeden 2. Tag je 10cc eingespritzt und den weiteren Verlauf, die Nebenwirkungen etc. genau beobachtet. Die Heilwirkung von Pansekal ist eben so gut, wie die von Trypaflavin, Panseptin oder Isravin und die Nebenwirkungen sind viel seltener als bei den drei letzteren zu finden. Was die Intervalle zwischen den einzelnen Injektionen anbelangt, so scheint die t?gliche Injektion wirksamer zu sein als die alle 2 Tage vorgenommene. Im grossen und ganzen ist das Pr?parat f?r die Behandlung der Gonorrhoe als ein wirksames Heilmittel der lokalen Behandlung mit Antigonorrhoicum empfehlenswert. en-copyright= kn-copyright= en-aut-name=YamamotoHarumi en-aut-sei=Yamamoto en-aut-mei=Harumi kn-aut-name=山本春海 kn-aut-sei=山本 kn-aut-mei=春海 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學皮膚科泌尿器科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1313 end-page=1318 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immunological Studies on Ultracentrifuged-Fraction from Sal. Enteritidis Part I. The Preliminary Studies on Immunizing Effect Using Supernatant and Particulated Fractions kn-title=S.enteritidis超遠心分画物質の免疫学的研究 第1編 感染防禦実験のための予備的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to study biochemical and serological properties of supernatant (Sf) and particulated (Rf) fractions of Sal. enteritidis, the author prepared two fractions by ultracentrifugation of ground cell suspension of the growing cell of two organisms. The organisms used throughout this study were selected among several strains of Sal. enteritidis in the light of virulence to mouse and were MURASHIMA's strain, which showed the highest virulence and TAKATA's strain, showed the lowest virulence. The following results were obtained. 1) Nitrogen and carbehydrate contents were very low in Rf compaired to Sf, especially it was markedly low in the case of nitrogen. 2) Rf showed oxidative ability only to succinate and lactata among the substrate related to TCA cycle, but Sf could oxidize many substrates tested in various degree. However, Rf Sf and of TAKATA's strain could oxidize only succinate in high degree. 3) The specific enzyme activity of Rf was not affected by irradiation of ultraviolet ray, but was decreased to 1/3~1/4 by exposure to heat, 56℃ 30 min., or by action of formalin or mersonin. 4) Antigenic capacities differed only little between Rf and Sf in the light of aggulutinin production to rabbit serum. 5) Rf gave less intense cutaneous reaction and was less virulent than Sf in examinations using rabbit, for the cutaneous test, and mouse, for the virulence test. en-copyright= kn-copyright= en-aut-name=YoshiokaTatsuji en-aut-sei=Yoshioka en-aut-mei=Tatsuji kn-aut-name=吉岡達治 kn-aut-sei=吉岡 kn-aut-mei=達治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=6 article-no= start-page=1453 end-page=1462 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Vergleichende Studien ?ber die St?rke der Wirkung einiger neuer adrenalinverwandter Stoffe auf die f?rdernden und hemmenden Fasern des Sympathicus (II. Mitteilung): Versuche am Blutdruck, Kaninchenohr- und Froschschenkelgef?ss kn-title=2-3新「アドレナリン」類似體ノ催進及ビ抑制性交感神經纖維ニ對スル作用強度比較研究(第2報)家兎血壓及ビ末梢血管ニ對スル作用比較 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Die zum Versuche herangezogenen neuen adrenalinverwandten Stoffe, Aminoacetobrenzkatechin, Sympatol und Ephetonal, haben auf den Blutdruck des Kaninchens eine steigernde Wirkung, die durch eine gewisse Dosis von Ergotamin oder Yohimbin gehemmt wird, was auf ihre sympathische Natur hinweist. Nur wirkt Aminoacetobrenzkatechin in kleinenen Dosen in manchen F?llen herabsetzend und erst bei h?heren, wenn auch nicht stark, steigernd. Hinsichtlich der blutdrucksteigernden Wirkung ist Sympatol am st?rksten, dann folgen Aminoacetobrenzkatechin und Ephetonal. Bei Aminoacetobrenzkatechin kann durch Vorbehandlung mit Ergotamin oder Yohimbin eine Umkehrung herbeif?hrt werden, w?hrend dies bei den 2 anderen Stoffen nicht der Fall ist. Was die vasokonstriktorische Wirkung dieser Gifte am Kaninchenohr- und Froschschenkelgef?ss anbelangt, so ist sie im allgemeinen bei Aminoacetobrenzkatechin und Sympatol st?rker, bei Ephetonal schw?cher. Bei dem Froschschenkelgef?ss aber bewirkt Aminoacetobrenzkatechin nur eine leichte Verengerung, obwohl seine minimale Konzentration ziemlich klein ist. Diese Resultate stimmen mit denen der vorigen Mitteilung ?berein und f?hren zu demselben Schluss, dass zwischen der f?rdernden und hemmenden Wirkung dieser 3 Stoffe ein ziemlich Parallelismus besteht. Im allgemeinen scheinen diese 3 Stoffe eine besonders starke Wirkung auf die hemmenden Fasern des Sympathicus auszu?ben. en-copyright= kn-copyright= en-aut-name=TachibanaKatsuo en-aut-sei=Tachibana en-aut-mei=Katsuo kn-aut-name=橘捷夫 kn-aut-sei=橘 kn-aut-mei=捷夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學藥理學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=6 article-no= start-page=1473 end-page=1479 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber den K?rperbau des Miracidiums von Paragonimus westermanni kn-title=肺臟「ヂストマ」「ミラチヂウム」ノ構造ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Das Miracidium von Lungendistoma ist an Form und Gr?sse und auch an K?rperbau sehr ?hnlich dem von Fasciolidae und Schistosomidae. Aus der n?heren Beschreibung, die Prof. Dr. M. Suzuki und von dem Verfasser bearbeitet wurde, sind die folgenden Merkmale als charakteristisch aufzuz?hlen; dadurch kann man das Paragonimusmiracidium von dem der obenangegebenen beiden Arten unterscheiden. 1) Die Wimperepithelzellen sind 17 an der Zahl und in 4 Reihen angeordnet: in der vorderen Reihe 6, in der zweiten Reihe 7, in der dritten Reihe 3, und in der vierten Reihe nur eins. 2) An dem vorderen Ende des Wurmk?rpers ist ein R?ssel vorhanden wie bei den Fasciolidae. 3) Keine Augenflecke, aber ein Paar von Sinnesorganen, wie bei den Schistosomidae. 4) Nur ein Paar von Terminalzellen vorhanden. Der Exkretionskanal bei diesem Wurme ist charakterisiert durch eine glomerulusartige Windung in ihrem Verlaufe. 5) Die Exsistenz der einzelligen Dr?se und des linsenartigen K?rpers ist sehr zweifelhaft bei diesem Paragonimusmiracidium. en-copyright= kn-copyright= en-aut-name=WatanabeMasumi en-aut-sei=Watanabe en-aut-mei=Masumi kn-aut-name=渡邊眞澄 kn-aut-sei=渡邊 kn-aut-mei=眞澄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學細菌學教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=6 article-no= start-page=1480 end-page=1495 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Beitr?ge zur postmortalen Ver?nderung der Leichenleber in verschiedenen Zeiten kn-title=死後ニ於ケル肝臟ノ化學的變化補遺 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Der Verfasser untersuchte die quantitativen Ver?nderungen des Reststickstoffs, des Phosphors und des Schwefels in der Kaninchenleber nach dem Tod des Versuchstieres. 1) Der Restsickstoff, Phosphor und Schwefel nahmen in der Leber mit der der Zeit nach dem Tode mehr und mehr zu. Die Zunahmegeschwindigkeit war je nach der Jahreszeit und der atomosph?rischen Feuchtigkeit w?hrend der Versuchszeit sehr verschieden. Im allgemeinen war sie im Sommer am gr?ssten, weniger gross im Herbst und Fr?hling und am kleinsten im Winter. 2) Im Winter zeigte der Schwefel bis zu 40 Tagen und der Phosphor bis zu 50 Tagen nach dem Tode mehr oder weniger Zunahme. Nach diesem Zeiten waren bei diesen Stoffen keine Weiteren Quantitativen Ver?nderungen zu bemerken. 3) Das Maximum des Reststickstoffes fand sich im Sommer. en-copyright= kn-copyright= en-aut-name=MomonoiKwanji en-aut-sei=Momonoi en-aut-mei=Kwanji kn-aut-name=桃井寛次 kn-aut-sei=桃井 kn-aut-mei=寛次 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學法醫學教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1319 end-page=1327 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immunological Studies on Ultracentrifuged-Fractions from Sal. Enteritidis Part U. The Protective Antigenicity of Supernatant and Particulated Fractions kn-title=S.enteritidis超遠心分劃物質の免疫学的研究 第2編 感染防禦実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using the same method described in the part I, the author prepared supernatant (Sf) and particulated (Rf) fractions from MURASHIMA's strain and TAKATA's strain respectively. And studied the protective antigenicity of these fractions. The results obtained were as follows. 1) No productive antigenicity was observed on the inoculatoin of Sf. However, the inoculation of Rf could give sufficient immunity by a single intraveneous inoculation: interperitoneal inoculation was inferior than intraveneous one in its effect. 2) By repeated inoculation of Rf from the highly virulent strain the animal became sensitive to a challenge of bacteria. Meanwhile repeated inoculation of Rf from the less virulent strain could give immunity enough to overcome challenge. 3) The prcductive antigenicity of Rf was inactivated either by exposure to heat, 56℃ 30 min, or by action of formalin or mersonin. 4) Sufficient immunity to prevent oral infection was acquired by inoculation of Rf from the highly visulent strain. en-copyright= kn-copyright= en-aut-name=YoshiokaTatsuji en-aut-sei=Yoshioka en-aut-mei=Tatsuji kn-aut-name=吉岡達治 kn-aut-sei=吉岡 kn-aut-mei=達治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1329 end-page=1341 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Alklphosphate Poisoning Part 1. Clinical Effects of PAM on Parathion Poisoning kn-title=有機燐剤中毒に関する研究 第1編 Parathion中毒に対するPAMの臨床効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=On 39 cases of parathion poisoning treated with PAM (pyridine-2-aldoxime methiodide) the author obtained the following results. 1. From cholinesterase determinations and clinical findings PAM has been found to be the most effective drug available at present for the treatment of parathion poisoning. 2. The effect appears promptly within 30--40 minutes of the treatment. 3. By administering PAM such symptoms as disturbance of consciousness, muscular fasciculation, salivation, bronchial secretion, convulsions, vomiting, and rasping in the lung, all disappear easily. Apart from these there may persist for quite same time such subjective symptoms as headache, miosis, pallor, quick breathing, speech difficulty, slow pupillary reflex, and numbness of limbs, but these are not dangerous. 4. If no improvement at all occurs after the administration of PAM, the case may be suspected as not paration poisoning. 5. As for the method of administration, 1.0 g PAM (40 ml 2.5% aqueous solution) is administered intravenously, and if no prompt effect appears another dose of 1.0 g PAM will be sufficient. 6. Occasionally vomiting accompanies the PAM injection, but it is considered as due to parathion, and there can be observed otherwise no other side-effect. 7. There is no need of concurrent use of atropine, and even in severe case the dose of atropine should be limited to 0.5-1.0 mg to suppress secretion. The use of a large amount of atropine, on the contrary, brings about the danger of atropine poisoning. 8. In extremely severe cases where even 2.0 g PAM shows little effect, PAM in the amount up to 4-5 g may be additionally given along with atropine. en-copyright= kn-copyright= en-aut-name=OkazakiShoichi en-aut-sei=Okazaki en-aut-mei=Shoichi kn-aut-name=岡崎昌一 kn-aut-sei=岡崎 kn-aut-mei=昌一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=799 end-page=804 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=About Two Case of Stomach Cancer Patients Complicating Armoured Pericard kn-title=胃癌に合併せる装甲心の2例について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recently we have been two stomach cancer patients complicating armoured pericard. These two cases are diagnosed by X-ray examination as "armoured pericard" which would be easily differentiated from calcification of mediastinal pleura etc. by means of lateral or oblique projection radiography and tomography, and could be fit for gastrectomy. en-copyright= kn-copyright= en-aut-name=YamamotoMichio en-aut-sei=Yamamoto en-aut-mei=Michio kn-aut-name=山本道夫 kn-aut-sei=山本 kn-aut-mei=道夫 aut-affil-num=1 ORCID= en-aut-name=NishishitaSoichi en-aut-sei=Nishishita en-aut-mei=Soichi kn-aut-name=西下創一 kn-aut-sei=西下 kn-aut-mei=創一 aut-affil-num=2 ORCID= en-aut-name=ShiakuTakeru en-aut-sei=Shiaku en-aut-mei=Takeru kn-aut-name=塩飽健 kn-aut-sei=塩飽 kn-aut-mei=健 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=6 article-no= start-page=1496 end-page=1509 dt-received= dt-revised= dt-accepted= dt-pub-year=1935 dt-pub=19350630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ein Fall von tuber?ser Hirnsklelose kn-title=結節性腦硬化症ノ1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verfasser berichten hier ?ber einen seltenen Fall von sog. tuber?ser Hirnsklerose. Der Kranke war ein 15 j?hriger J?ngling. Von Kindheit an zeigten sich bei ihm einige Symptome der tuber?sen Hirnsklerose, d. h. Adenoma sebaceum und Geistesarmut u. s. w. Am 23. August 1932 klagte er ganz pl?tzlich ?ber Bauchschmerzen, es trat Erbrechen, Bewustseintr?bung und Fieber von ca. 39° bis 40°C, auf. Am 28. August starb er unter Symptomen von acuter Encephalitis und wurd am n?chsten Tage seziert. Die pathologischanatomischen Befunde machten klar, dass es sich bei diesem Falle um eine tuber?se Hirnsklerose mit mehreren Tumoren, die sich an Hirn, Niere Herzen, Lunge und Haut fanden, handelte. Der Tumor am Gehirn stammte aus dem Vorderhorn des rechten Seitenventrikels. Bei tuber?ser Hirnsklerose sind Lipom des Herzens und Adenom der Lunge, wie sie in Unserem Falle beobachtet worden sind, ?usserst selten und bis in der japanischen medizinischen Literatur noch nicht beschrieben worden. Verfasser sind der Ansicht, dass diese Tumoren und die Ver?nderung des Gehirns Missbildungen sind; im Hiublick auf das Verhalten der Hyperplasie der Zellen kann ein Teil der krankhaften Erscheinungen als Gewebsmissbildung und ein Teil als echte geschwulstm?ssige Ver?nderung gelten. en-copyright= kn-copyright= en-aut-name=KikuzawaT. en-aut-sei=Kikuzawa en-aut-mei=T. kn-aut-name=菊澤隆尚 kn-aut-sei=菊澤 kn-aut-mei=隆尚 aut-affil-num=1 ORCID= en-aut-name=TakigawaK. en-aut-sei=Takigawa en-aut-mei=K. kn-aut-name=瀧川克巳 kn-aut-sei=瀧川 kn-aut-mei=克巳 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學法醫學教室 affil-num=2 en-affil= kn-affil=岡山醫科大學柿沼内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=805 end-page=815 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on Effects of Parabiosis Formation on the Brain Metabolism of ep-Mouse Part T Effects of Parabiosis on Water, Sodium and Potassium Contents in the Brain of ep-Mouse kn-title=ep系マウスの脳代謝におよぼすparabiosisの影響に関する実験的研究 第1編 ep系マウス大脳の含水量およびNa,K含有量におよぼすparabiosisの影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Parabiosis was performed between an ep-mouse, having had convulsive seizures, and a CF(1)-mouse, one of normal other species, and biochemical changes in the brain induced by this procedure were investigated. The results of this experiment were as follows: 1. Water content in the brain of the ep-mouse was larger than in the one of the CF(1). It was decreased 6 days after the procedure to the level between the contents in the ep-and the CF(1)-mice of preparabiosis period. At the 12 th postparabiosis day, both contents were decreased to regain the preparabiosis level of the CF(1). The variation in the course was due to the change of the free water content but not due to the bound water content. 2. Total sodium content in the ep-mouse was remarkably large in contrast to the one in the CF(1)-mouse. It was gradually decreased to the level of the CF(1) at the 12 th postparabiosis day. 3. Total potassium content in the ep-mouse was also markedly large in contrast to the one in the CF(1)-mouse, and it followed the tendency of the variation as sodium content. en-copyright= kn-copyright= en-aut-name=MasukawaSadahiko en-aut-sei=Masukawa en-aut-mei=Sadahiko kn-aut-name=増川禎彦 kn-aut-sei=増川 kn-aut-mei=禎彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1(陣内)外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1343 end-page=1349 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Alkylphosphate Poisoning Part 2. Toxicity and In Vivo Distribution of PAM (pyridine-2-aldoxime methiodide) kn-title=有機燐剤中毒に関する研究 第2編 PAM (pyridine-2-aldoxime methiodide) の毒性並に生体内分布 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the use of any drug there always arise problems of its effect and side-effect as well as its toxicity and distribution in vivo. Therefore, the author studied these problems on PAM from various angles and obtained the following results. 1. The median lethal dosage (LD(50)) of PAM on mice has been found to be: 159 mg/kg in the case of intravenous administration; 247 mg/kg in peritoneal injection; 340 mg/kg in subcutaneous injection; and 1960 mg/kg in oral administration, proving that the limit is sufficiently within the range of commonly used drugs. 2. Histological changes occurring after PAM adminstration are consisted mainly of disturbances in the circulatory system, namely, hyperemia, congestion and slight hemorrhage, but rarely of parenchymal disturbances. 3. When a large amount of PAM is administered to rabbits, there occurs a rise in the blood cholinesterase activity at first later followed by its fall. However, the fall being down to -25 per cent, it can not be considered as due to the toxicity of PAM. 4. In the oral adminstration of PAM to rabbits, PAM can be detected considerably in stomach, intestines, and in their contents, but it is distributed fairly evenly in other viscera. Moreover, in the case of the intravenous administration of PAM is also distributed in similar manner. It diminishes relatively promptly from the body fluid. Judging from these findings as well as from results of clinical observations, there is no danger of toxicity of PAM in the amount as used in our clinic. en-copyright= kn-copyright= en-aut-name=OkazakiShoichi en-aut-sei=Okazaki en-aut-mei=Shoichi kn-aut-name=岡崎昌一 kn-aut-sei=岡崎 kn-aut-mei=昌一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1351 end-page=1357 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Alkylphosphat Poisoning Part 3. Effects of Oxime Compounds on Alkylphosphate Poisoning kn-title=有機燐剤中毒に関する研究 第3編 Oxime化合物の有機燐剤中毒に対する効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By selecting 4 oxime compounds possessing pyridine nucleus in the molecular construction, namely, PATD, PPATD, PPAPD, and PAD, the author compared their therapeutic effects on alkylphosphate poisoning with the effect of PAM. 1. As for the therapeutic effect on alkylphosphate poisoning in mice, when administered in the maximum safety dose, PATD and PPATD are superior to PAM, but on scrutinous examinations there can be recognized not any significant difference. Effect of PPAPD is about the same as that of PAM. 2. Both PAM and PATD are most effective when administered concurrently with the intravenous administration of alkylphosphate, but as the time before or after the administration of alkylphosphate lengthens, the effect of drugs decreases proportionately. 3. Atropine used concurrently with these oxime compounds yields no better results than without it. 4. The effect of PATD is slightly more lasting than PAM, but the difference is not significant. 5. PATD has been proven to possess a reactivating action on rabbit blood cholinesterase just as PAM. Consequently it is assumed that the effective mechanism of both drugs is same. 6. When an equal dose of PAD and PAM is administered to the mice with ethylparathion poisoning, PAD is inferior to PAM in improving the mortality rate of the mice. 7. There seems to be no benefit in administering intramuscularly 15 mg/kg PAD concurrently with the administration of various oximes. en-copyright= kn-copyright= en-aut-name=OkazakiShoichi en-aut-sei=Okazaki en-aut-mei=Shoichi kn-aut-name=岡崎昌一 kn-aut-sei=岡崎 kn-aut-mei=昌一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=817 end-page=825 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on Effects of Parabiosis Formation on the Brain Metabolism of ep-Mouse Part U Effects of Parabiosis on Cholinesterase Activity and Acetylcholine Content in the Brain of ep-Mouse kn-title=ep系マウスの脳代謝におよぼすparabiosisの影響に関する実験的研究 第2編 ep系マウス大脳のcholinesterase活性値およびacetylcholin含有量におよぼすparabiosisの影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Parabiosis was performed between an ep-mouse, having had convulsive seizures, and a CF(1)-mouse, one of the normal other species, and biochemical changes as to cholinesterase activity and acetylcholine content in the brain induced by this procedure were investigated. The results of this experiment were as follows: 1. Cholinesterase activity was significantly low in the brain of the ep-mouse compared with the CF(1)-mouse. This difference was averaged by parabiosis formation, and both activities were decreased to the preparabiosis level of the ep-mouse at the 12 th postparabiosis day. 2. Total acetylcholine content was definitely large in the brain of the ep-mouse compared with the CF(1)-mouse, but it was rapidly recovered to the preparabiosis level of the CF(1)-mouse. In contrast to it, the content in the CF(1)-mouse remained unchanged throughout the postparabiosis period. en-copyright= kn-copyright= en-aut-name=MasukawaSadahiko en-aut-sei=Masukawa en-aut-mei=Sadahiko kn-aut-name=増川禎彦 kn-aut-sei=増川 kn-aut-mei=禎彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1(陣内)外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=827 end-page=833 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on Effects of Parabiosis Formation on the Brain Metabolism of ep-Mouse Part V Effects of Parabiosis on Glutamic Acid, γ-Aminobutyric Acid (GABA) and Aspartic Acid Content in the Brain of ep-Mouse kn-title=ep系マウスの脳代謝におよぼすparabiosisの影響に関する実験的研究 第3編 ep系マウス大脳のglutamic acid,γ-aminobutyric acidおよびaspartic acid含有量におよぼすparabiosisの影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Biochemical changes as to amino acid metabolism were investigated in the brain of an ep-mouse, having had convulsive seizures, after parabiosis formation with a CF(1)-mouse, one of the normal other species, and the results of this experimeot were as follows: 1. Glutamic acid content was small in the brain of the ep-mouse compared with the CF(1)-mouse. They were approaching between the two levels 6 days after the procedure. Then, they were decreased below the preparabiosis level, showing insignificant defference between the both contents at the 12 th postparabiosis day. 2. GABA content was large in the brain of the ep-mouse compared with the CF(1)-mouse, but both contents were averaged between the levels 6 days after the procedure. They were recovered to the preparabiosis level of the CF(1)-mouse at the 12 th postparabiosis day. 3. Aspartic acid content was slightly large in the brain of the ep-mouse compared with the CF(1)-mouse. The difference was minimized after the procedure, and recovered to the preparabiosis level of the CF(1)-mouse at the 12 th postparabiosis day as in the case of GABA content. en-copyright= kn-copyright= en-aut-name=MasukawaSadahiko en-aut-sei=Masukawa en-aut-mei=Sadahiko kn-aut-name=増川禎彦 kn-aut-sei=増川 kn-aut-mei=禎彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1(陣内)外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1359 end-page=1368 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Alkylphosphate Poisoning Part 4. Fluctuations of Visceral Cholinesterase in Alkylphosphate Poisoning and in the Cases Treated with Oxime Compounds kn-title=有機燐剤中毒に関する研究 第4編 有機燐剤中毒並にOxime治療による臓器Cholinesteraseの消長 en-subtitle= kn-subtitle= en-abstract= kn-abstract=After studying disturbing actions of various alkylphosphates such as ethylparathion, methylparathion, EPN, TEPP, Pestox 3, malathon, diazinon and dipterex on cholinesterase of the brain, liver, spleen and muscles in mice, the author observed the reactivating effects on cholinesterase by administering PAM, PATD, PPATD, PPAPD, PAD, DAM, and MINA to these animals. The results are as follows. 1. In the organs of the animals administered with alkylphopshates in the amount about half LD(50), cholinesterase in various organs is decreased to 30-60 per eent of the normal level. It has been found that muscle cholinesterase is markedly disturbed in the ease of TEPP administration, while the disturbance of brain cholinesterase is markedly less in the administration of Pestox-3. 2. The brain cholinesterase disturbed by alkylphosphates can be brought back to a certain degree with administration of oxime cempounds. Especially in ethylparation poisening the effect is just as good as thaf of PAM, brining back almost to the normal level. 3. The recovery rate of the brain cholinesterase parallels most closely with the theapeutic effect, judging from the mortality rate. 4. The behavior of cholinesterase differs according to the combination of alltylphosphates and oixme compounds and to different organs, but with an exception of Pestex-3, cholinesterase recovers in some organ. Only in the case of DAM and MINA there can be observed no fluctutions at all exepting muscle cholinesterase. 5. The reactivating action of oximes on the vesceral cholinesterase is only transient. 6. PAD is less effective on alkylphospate poisonning than PAM, and the concurrent use of PAD with any one of quarternary oximes does not enhance the recovery of cholinesterase activity. en-copyright= kn-copyright= en-aut-name=OkazakiShoichi en-aut-sei=Okazaki en-aut-mei=Shoichi kn-aut-name=岡崎昌一 kn-aut-sei=岡崎 kn-aut-mei=昌一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=835 end-page=840 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies of the Calcium Metabolism in the ep-Mouse Part 1 Calcium Content in Various Tissue and Urine of ep-Mouse kn-title=ep系マウスのCalcium代謝に関する研究 第1編 ep系マウスの組織Ca量および尿中排泄量に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Calcium content in the serum, bone, muscle, brain tissue and urine of the ep-mouse were measured. The results were as follows; 1) Urinary calcium excretion of the ep-mouse was higher than that of normal mouse. 2) As to the quantitative change of urinary calcium excretion of the ep-mouse in the days following birth, it was observed that the urinary calcium excretion was highest in the early stage of immaturity, thereafter gradually decreased in the late stage, then moderately increased again in the mature stage. 3) As to the quantitative change of urinary calcium excretion during convulsions, it was observed that the urinary calcium excretion decreased in one hour following the convulsion, then gradually increased, attaining the normal range within five hours. 4) No significant difference was found in the calcium content of serum, bone and brain of ep-mouse in comparison to normals, but decreased calcium content was observed in the muscle of ep-mouse. 5) Calcium content in the brain of ep-mouse increased a little during the convulsive stage as compared to that of nonconvulsive stage, but, after convulsion, it gradually reached the normal range. en-copyright= kn-copyright= en-aut-name=KakudaMasayoshi en-aut-sei=Kakuda en-aut-mei=Masayoshi kn-aut-name=角田正良 kn-aut-sei=角田 kn-aut-mei=正良 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1(田中)外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1369 end-page=1376 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Pure Pulmonic Stenosis Report of Two Cases and Review of the Literature kn-title=純粋な肺動脈弁狭窄症二例報告と文献考察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Two typical cases of pure, isolated pnlmonic stenosis were studied by means of cardiac catheteriration during the past 12 months. On one of them the Brock type of valvulotomy was performed and this is the first case of pulmonic stenosis operated surgically in Korea. The results of the pulmonic valvulotomy was satisfactory initially. The patient had improved subjectively and venous pressure and circulation time returned to the normal level. However, 4 month postoperatively follow up study showed worsening of subjective symptoms again and re-catheterization was performed. There was an increased right ventricalar pressure. The reason of the failure of the operation was discussed. en-copyright= kn-copyright= en-aut-name=SohnIsaack en-aut-sei=Sohn en-aut-mei=Isaack kn-aut-name=孫宜錫 kn-aut-sei=孫 kn-aut-mei=宜錫 aut-affil-num=1 ORCID= en-aut-name=LimSung-yu.ll en-aut-sei=Lim en-aut-mei=Sung-yu.ll kn-aut-name=林成律 kn-aut-sei=林 kn-aut-mei=成律 aut-affil-num=2 ORCID= en-aut-name=LeeYoung-Lin en-aut-sei=Lee en-aut-mei=Young-Lin kn-aut-name=李永麟 kn-aut-sei=李 kn-aut-mei=永麟 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=国立Seoul大学校医科大学 affil-num=2 en-affil= kn-affil=国立Seoul大学校医科大学 affil-num=3 en-affil= kn-affil=国立Seoul大学校医科大学 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=841 end-page=847 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies of the Calcium Metabolisum in the ep-Mouse Part 2 (45)Ca Metabolism in the ep-Mouse kn-title=ep系マウスのCalcium代謝に関する研究 第2編 ep系マウスにおける(45)Ca代謝に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=(45)Ca was injected into the abdominal cavity of normal mouse. Thereafter, (45)Ca incorporated in the blood, bone, brain, cartilago, muscle, spleen, liver and kidney was investigated, and it was observed that the concentration of (45)Ca incorporated in the various tissues was stablest 24 hours following the injection. Thus, investigations were carried out at this time to compare the concentration of (45)Ca in the various tissues of the ep-mouse to that of the normal mouse and its relative efect on the characfer of the convulsion. The results were as follows; 1) Blood (45)Ca content of the ep-mouse was higher than that of normal mouse, and this was not affected by convulsions. 2) There was no significant difference between the ep-mouse and normal mouse in (45)Ca content incorporated in the bone, nor any effect in the convulsive nature. 3) (45)Ca concentration incorporated in the brain of ep-mouse was markedly lower than that of normal mouse, this concentration was slightly increased by convulsion. 4) (45)Ca concentration incorporated in the muscle of ep-mouse was lower than that of normal mouse, and this concentration was slightly increased by convulsion. en-copyright= kn-copyright= en-aut-name=KakudaMasayoshi en-aut-sei=Kakuda en-aut-mei=Masayoshi kn-aut-name=角田正良 kn-aut-sei=角田 kn-aut-mei=正良 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1(田中)外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1377 end-page=1391 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Pentose Formation by Bacteria Part I Pentose Formation from Several Kinds of Carbon Sources kn-title=細菌による五炭糖の生成 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using St. aureus, sh. flexneri 2a and Sal. typhi 57, the author carried out the studies on pentose formation from glucose or other substrates. The following results were obtained. 1) A fairly large amount of pentose was formed and accemulated from glucose, gluconate, glycerophosphate, lactate or pyruvate in every strain of the bacteria tested in the presence of AM or DNP in corcentrations of 3×10(-4) and 10(-3)M. 2) Pentose was supposed to be formed from glucose through gluconate in the case of St. aureus, but was probably formed through C(3)-comound in the case of Sh. flexneri 2 a and Sal. typhi 57. 3) It was postulated that AM and DNP inhibited the break-down of pentose to C(3)-compound; however, did not inhibit the synthesis of pentose from C(3)-compound. Part U Effect of Changes in Culture Condition on Pentose Formation With the use of Sh. flexneri 2 a as test organism, the author investigated the effect of changes in culture condition on pentose formation and obtained the following results. 1) The bacterial cells cultured on glucose added media showed further oxidation of pyruvate to a less extent and was able to produce pentose to a greater extent from glucose and C(3)-compound in glucose metabolism. 2) The bacterial cells cultured on glucose and α, α-dipyridyl added media was more inferior in the further oxidation of pyruvate, and was more promoted pentose formation rate. 3) Pentose was produced to a greater extent under anaerobic condition than under aerobic condition. 4) From theee results, it could be stated that the suppresion of pyruvate oxidation accelerated the reaction rate which produced pentose from glucose through C(3)-compound. en-copyright= kn-copyright= en-aut-name=HonmatsuKakushi en-aut-sei=Honmatsu en-aut-mei=Kakushi kn-aut-name=本松格史 kn-aut-sei=本松 kn-aut-mei=格史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=849 end-page=852 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies of the Calcium Metabolism in the ep-Mouse Part 3 The Effect of Several Drugs on the (45)Ca Incorporation in the ep-Mouse Brain kn-title=ep系マウスのCalcium代謝に関する研究 第3編 ep系マウス脳への(45)Ca移行に及ぼす薬物の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Two groups of the ep-mouse and normal mouse were subjected to intraperitoneal injection of (45)Ca, and simultaneous injections of ethylalcohol, histamine, Kallikrein, vitamin E or benzylimidazoline. Then, 6 hours after the administration, (45)Ca concentration incorporated in brain and liver was investigated. The results were as following; 1) (45)Ca concentration incorporated in brain was moderately increased, with administration of these, especially with Kallikrein and benzylimidazoline. 2) (45)Ca concentration incorporated in liver was remarkably increased with administration of ethylacohol, vitamin E, and remarkably with histamine, Kallikrein, benzylimidazoline. 3) With regard to increment in the ratio of (45)Ca incorporation into brain and liver after administration of peripheral vasodilatation on circulatory accelerator, significant difference was hardly recognized between ep-mouse and normal mouse. en-copyright= kn-copyright= en-aut-name=KakudaMasayoshi en-aut-sei=Kakuda en-aut-mei=Masayoshi kn-aut-name=角田正良 kn-aut-sei=角田 kn-aut-mei=正良 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1(田中)外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=853 end-page=862 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies of Convulsive Seizure Induced by Decadron Part 1 Studies of Convulsive Seizure Induced by Intrathecal of Decadron kn-title=デカドロン痙攣に関する実験的研究 第1編 デカドロン注射液の膸腔内投与により惹起される痙攣に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Several sexual and adrenal hormones were injected intrathecally to a dog, mouse, and rat. And the effects of these substances on brain activity, especially on convulsive seizure, were investigated. The results of these investigations were as follows: 1) Aspecial type of tonic convulsion was observed after a short period of intra cysternal administration of Decadron. 2) The same type of convulsion was observed also in the case of the mouse or rat after the administration of Decadrin. 3) Spike waves were observed in the EEG findings during the convulsion induced by Decadron. 4) Acetylchorine content increased and ChE activity decreased in the Brain during the convulsion induced by Decadron. en-copyright= kn-copyright= en-aut-name=MiyakeShintaro en-aut-sei=Miyake en-aut-mei=Shintaro kn-aut-name=三宅新太郎 kn-aut-sei=三宅 kn-aut-mei=新太郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1(田中)外科教室 END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=6 article-no= start-page=1492 end-page=1496 dt-received= dt-revised= dt-accepted= dt-pub-year=1933 dt-pub=19330630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=雜報 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡山医学会 kn-aut-sei=岡山医学会 kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1407 end-page=1422 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Catalase Activity of Babteria kn-title=細菌のカタラーゼ活性について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Part T Effect of Added Substance to the Media on Catalase Activity Using Sh. flexneri 2 a and Sal. typhi 57 as test organism, the author studied the effect on calase activity of bacteria by adding a certain kind of substance into culturing media, the following results were obtained. 1) The catalass activity was not influenced by the addition of lactate, pyruvate or succinate into media, but was decreased by addtion of glucose. 2) A marked decrease in the catalase activity was observed by addition of KCN or NaN(3), in dilution of 1/3×10(-4)M; whereas no change in other enzyme activity was observed by the addition of these substance. 3) The addition of α, α'-dipyridyl or oxine, in dilutions of 20-30 mg/L, showed marked decrease in oxidative ability of bacteria of pyruvarte, and the decrease in catalase activity was simultaneously observed only in Sh. flexneri. Part U Oxidation of glucose and alanine by catalase deficient bacteria Using Sh. flexneri 2 a, Sh. dysenteriae 4 and D. pneumoniae U, the author studied the enzymatic properties of the catalase active and inactive bacterial cells mentioned above by means of volumetric studies of glucose and alanine oxidation and also studied the effect of these cells on normal or acatalasemic erythrocytes, especially on hemoglobin of the erythrocytes. The following results were obtained. 1) As the cells of Sh. flexneri 2 a grown on KCN or NaN(3) added nutrient agar media was lacking catalase activity, the organism could'nt decompose H(2)O(2) produced throuth the course of glucose or alanine metabolism. So formed pyruvate by the metabolism was oxidized by H(2)O(2) inversely. And hemoglobin was oxidized to methemoglobin, when erythrocytes were added to the reaction media. 2) Sh. dysenteriae 4 is failing catalase and the production of H(2)O(2) was not detected at all or only scantily on the cells grown on any kind of media. 3) D. pneumoniae U is also failing catalase, but the production of H(2)O(2) was remarkably high. en-copyright= kn-copyright= en-aut-name=AkiyamaKenji en-aut-sei=Akiyama en-aut-mei=Kenji kn-aut-name=秋山健二 kn-aut-sei=秋山 kn-aut-mei=健二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=863 end-page=867 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies of Convulsive Seizure Induced by Decadron Part 2 Studies of the Active Principle in Decadron Solution Effective in Inducing Convulsion kn-title=デカドロン痙攣に関する実験的研究 第2編 デカドロン注射液中の痙攣惹起成分に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Decadron solution for injection contains Dexamethasone-21-phosphate disodium, phenol, creatine, sodium citrate, sodium bisulfite, and sodium hydroxide. Therefore, the question of which substance of these is really effective for inducing convulsion, was investigated using mice. The results of the present studies were as follows: 1) Sodium citrate is the only substance in the Decadron solution which induces a convulsive seizure, similar to the Decadron Convulsion. 2) Erection the tail and tachypnea were observed in mice after administration of dexamethasone-21-phosphate disodium, but no convulsive seizure was recognized by dexamethasone-21-phosphate disodium itself. 3) In the case of simultaneously administered sodium citrate and Dexamethasone-21-phosphate, a Decadron type of convulsive seizure was observed. Therefore it was suggested that dexamethasone played the roll of an activat or for the convulsive seizure. en-copyright= kn-copyright= en-aut-name=MiyakeShintaro en-aut-sei=Miyake en-aut-mei=Shintaro kn-aut-name=三宅新太郎 kn-aut-sei=三宅 kn-aut-mei=新太郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1(田中)外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=869 end-page=875 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies of Convulsive Seizure Induced by Decadron Part 3 Studies of the Mechanism of Inducing Convulsive Seizure by Decadron kn-title=デカドロン痙攣に関する実験的研究 第3編 デカドロン痙攣の作用機序に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The mechanism of inducing convulsive seizure by Decadron was investigated as followings: 1) No convulsive seizure was observed after apllying Decadron solution at the motor area of cerebral cortex, but the typical convulsive was observed only by administrating it directly at Nucleus caudatus. 2) The convulsion induced by Decadron could be inhibited by Ca. Mg and homocarnosine. 3) Amongst sodium citratum like substances, citric acid, L-malic acid and oxalic acid were found to elicit the convulsion as Deeadron induced convulsion, but such as malonic acid, fumaric acid, maleic acid, α-ketoglutaric acid, succinic acid, oxalacetic acid and acetic acid were not. 4) Therefore, it was suggested that citric acid conbined in a non ion "complex" with Ca or Mg which inhibited irritability of the mortor neuron. And on the other hand, dexamethasone played the roll of an activator for inducing convulsion. These reactions in the brain are the most impotant factors for inducing the convulsive seizure. en-copyright= kn-copyright= en-aut-name=MiyakeShintaro en-aut-sei=Miyake en-aut-mei=Shintaro kn-aut-name=三宅新太郎 kn-aut-sei=三宅 kn-aut-mei=新太郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1(田中)外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=877 end-page=891 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Megakaryocytes in the Spleen by Splenic Tissue Culture Method Part 1. Megakaryocytes in the Spleen of the Rodent (Mice, Rats, Guinea Pigs, and Rabbits) kn-title=脾組織培養法による脾内巨核球に関する研究 第1編 齧歯類(マウス,ラツテ,モルモツト,及び家兎)脾内巨核球について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Followings are the results of studies on megakaryocytes in the spleen of the rodent of the successive stages from the embryonic stage up to the adult. 1) In the rodent, megakaryocytes are always found in the spleen from the embryonic stage up to the adult, especially in large numbers in the infant. Among the rodent, the largest numbers of megakaryocytes are found in the spleen of mice, less in rats, and only very small numbers in guinea pigs and rabbits. 2) No significant morphological differences are noted between megakaryocytes in the spleen and those in the bone marrow. 3) By splenic tissue culture method, megakaryocytes in the spleen are found to have deformated movement, pseudopodial movement, and tentacle formation for the platelet separation as those in the bone marrow. 4) Megakaryocytes in the spleen of mice and rats have motility and ability of platelet formation from the embryonic up to the infant stage, but these functions are found to be decreased during the adolescent and adult life. In guinea pigs and rabbits, the functions of megakaryocytes in the spleen are decreased after the mid-embryonic stage. 5) A correlation is noted between the functions of the megakaryocytes and erythropoiesis in the spleen, a rise and fall of the one being accompanide by the other. en-copyright= kn-copyright= en-aut-name=HanzawaAtsumasa en-aut-sei=Hanzawa en-aut-mei=Atsumasa kn-aut-name=半澤敦正 kn-aut-sei=半澤 kn-aut-mei=敦正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1439 end-page=1444 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Cell Toxin Produced by X-Ray Irradiation Part 2. The Morphological Changes and in Vivo Reactions of the Succinic Dehydrogenase System in Ehrlich Ascites Tumor Cells Induced by the Unsaturated Fatty Acid Fraction Extracted from the Rabbit Liver after X-ray Irradiation kn-title=X線照射時に発生せる細胞毒の研究について 第二編 X線照射家兎より抽出した不飽和脂肪酸分画のEhrlich腹水癌のコハク酸脱水素系に於ける形態学的変化並びに生体内反応について en-subtitle= kn-subtitle= en-abstract= kn-abstract=In Part 1. the author investigatad the effects of the unsaturated fatty acid fraction extracted from the rabbit liver after x-ray irradiation on the succinic dehydrogenase system in Ehrlich ascites tumor cells and in the normal rabbit liver, and it was concluded that although this fraction does not greatly affect the normal liver cells, at a higher concentration it seems to induce cell degeneration which in turn results in a decrease in the respiratory enzyme activity. In the present experiment the author studied the morphological changes brought about by this substance in Ehrlich ascites tumor cell and the in vivo changes induced by it in the succinic dehydrogenase system. In conducting this experiment the results obtained by Yamamoto et al. of our department were referred to. With respect to the morphological changes in the tumor cells, it was observed that this substance acting for a short period of time will accelerate the respiratory enzyme activity transiently while when acting for a longer period, it decreases the activity. These findings agree more or less well with the results in Part 1. Even in the in vivo reactions the respiratory enzyme activity in the tumor cells is elevated temporarily and when acting for a longer period of time this substance decreases the activity. From these findings it is concluded that this substance does elevate the respiratory enzyme activity transiently but when it acts for a longer period of time, it seems to bring about a fall in the activity and further acting directly on the respiratory enzymes it induces the disorder in respiration. en-copyright= kn-copyright= en-aut-name=ShiakuMidori en-aut-sei=Shiaku en-aut-mei=Midori kn-aut-name=塩飽緑 kn-aut-sei=塩飽 kn-aut-mei=緑 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線科医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1445 end-page=1453 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of Electrical Stimulation (In Vitro) on the Metabolism of the Brain Part 1. Influences of Electrical Stimulation (In Vitro) on the Cereral Tissue Respiration kn-title=電気刺戟(in vitro)の脳物質代謝におよぼす影響 第1編 電気刺戟(in vitro)の大脳組織呼吸におよぼす影響 en-subtitle= kn-subtitle= en-abstract=Using slices and homogenates of the cerebral cortex of albino rats in the K.R.P. solution with glucose and glutamic acids as substrate, the author studied the tissue respiration in vitro giving electrical stimualtion, and obtained the following results. 1. In the case with the use of homogenate with glucose the tissue respiration was accelerated about 70 per cent by the electrical stimulation. 2. The percentage of the acceleration in the tissue respiration by electrical Stimulation in the case of cerebral slices was 463 percent on the average with 12 mM glucose as substrate, and 270 per cent on the average with M/50 glutamic acid as substrate. 3. In addition, it seems that in the case using glutamic acid smaller slices yield higher acceleration of the tissue respiration. 4. Even without glucose as substrate the respiration is considerably accelerated by electrical stimulation. 5. In the case where the electrical stimulation is given by Augospel apparatus (a low frequency therapeutic apparatus) to the cerebral cortex slices with glucose as substrate, the percentage of the respiration acceleration was 244 per cent. kn-abstract=1) K. R. P.溶液中のダイコクネズミ大脳皮質切片及びホモジネートにin vitro電気刺戟を加え,ブドウ糖及びグルタミン酸基質における組織呼吸を調べた. 2) ブドウ糖基質ホモジネートでは,電気刺戟によつて,その呼吸は70%近く促進された. 3) 大脳皮質切片の電気刺戟による呼吸促進率は, 12mMブドウ糖基質では平均463%, M50グルタミン酸基質では平均270%であつた. 4) 尚,グルタミン酸基質の場合,切片の小さい方が呼吸促進率は大のようであつた. 5) 又,基質なしでも電気刺戟によつて相当の呼吸促進がみられた. 6) ブドウ糖基質大脳皮質切片に, Augospelによる電気刺戟を加えた場合の呼吸促進率は244%であつた. en-copyright= kn-copyright= en-aut-name=KumashiroHisashi en-aut-sei=Kumashiro en-aut-mei=Hisashi kn-aut-name=熊代永 kn-aut-sei=熊代 kn-aut-mei=永 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=893 end-page=902 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Megakaryocytes in the Spleen by Splenic Tissue Culture Method Part 2. Megakaryocytes in the Spleen of the Carnivora (Dogs and Cats) kn-title=脾組織培養法による脾内巨核球に関する研究 第2編 食肉類(イヌ及びネコ)脾内巨核球について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Among the mammalia, the carnivora (dogs and cats) was chosen to make studies mainly by our clinical tissue culture method on megakaryocytes in the spleen of the successive stage from newborn up to adult. Followings are the results. 1) In dogs and cats, megakaryocytes are found in the spleen from newborn up to adult. During newborn, dogs have more megakaryocytes in the spleen than cats, but the reverse comes to be true during the following stages. 2) In dogs and cats, no significant morphological differences are noted between megakaryocytes in the spleen and those in the bone marrow. 3) By splenic tissue culture method, megakaryocytes in the spleen are found to have motility as those in the bone marrow. Ability of platelet separation from megakaryocytes in the spleen are found during newborn and infancy (1 month of age) in dogs, and during newborn in cats. During the successive stages of growth, the functions of megakaryocytes are noted to be decreased. 4) A correlation is noted in dogs and cats between the functions of megakaryocytes and erythropoiesis in the spleen, a rise and fall of the one being accompanied by the other. en-copyright= kn-copyright= en-aut-name=HanzawaAtsumasa en-aut-sei=Hanzawa en-aut-mei=Atsumasa kn-aut-name=半澤敦正 kn-aut-sei=半澤 kn-aut-mei=敦正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1455 end-page=1461 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of Electrical Stimulation (In Vitro) on the Metabolism of the Brain Part 2. Influences of Electrical Stimulation (in vitro) on the Cerebral Nitrogen Metabolism kn-title=電気刺戟(in vitro)の脳物質代謝におよぼす影響 第2編 電気刺戟(in vitro)の大脳窒素代謝におよぼす影響 en-subtitle= kn-subtitle= en-abstract=Using homogenates and slices of the cerebral cortex obtained from albino rats the author studied the influences of electrical stimulation (in vitro) on the formation of ammonia (NH(3)) and obtained the following results. In the case of homogenate an increase in the NH(3) production was observed while with slices a decrease. Howevar, in the case of slices an acceleration in the production of glutamine could also be recognized. Thus, it is assumed that in the case of the slices the decrease in the NH(3) production is in reality due to NH(3) being consumed in the processes of the glutamine production. Therefore, it can be said that the electrical stimulation (in vitro) accelerates the synthesis of glutamine in the cerebral cortex slice. This fact has been confirmed also by the experiments conducted with the additicn of NH(3) ion and sodium glutamate. kn-abstract=ダイコクネズミ大脳ホモジネート及び,大脳皮質切片に, in vitroで電気刺戟を加え,アンモニヤ発生に及ぼす影響をみた.その結果,ホモジネートでは,アンモニヤ発生の増加をみ,切片では,アンモエヤ発生の減少がみられた.所が切片では同時にグルタミン生成の促進もみられた. 従つて切片の場合のアンモニヤ発生の減少と云うのは,実は生成されるアンモニヤが,グルタミンとしてとらえられる事によるのではないかと推論した.従つて電気刺戟(in vitro)は大脳皮質切片のグルタミン合成系を促進すると云うことになる. このことは更に,アンモニウムイオンとグルタミン酸ソーダを基質とした実験においても確かめられた. 又,α-Keto glntaric acidとNH4Clからのグルタミン酸生成系に通電しても,これを促進せしめるようであつた. en-copyright= kn-copyright= en-aut-name=KumashiroHisashi en-aut-sei=Kumashiro en-aut-mei=Hisashi kn-aut-name=熊代永 kn-aut-sei=熊代 kn-aut-mei=永 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=903 end-page=912 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Megakaryocytes in the Spleen by Splenic Tissue Culture Method Part 3. Megakaryocytes in the Human Spleen kn-title=脾組織培養法による脾内巨核球に関する研究 第3編 ヒト脾内巨核球について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Followings are the results of studies by our clinical tissue culture method mainly on motility and ability of platelet formation of megakaryocytes in the spleen of human embryo and a patient with osteomyelofibrosis. 1) Megakaryocytes are always found in the spleen of human embryo, and no significant morphological differences are noted from those in the bone marrow. 2) Deformated movement, pseudopodial movement, and tentacle formation for the platelet formation are noted on megakaryocytes in the spleen of human embryos. As for functions of megakaryocytes, motility and ability of the platelet formation are significantly found at 4 month of age, but are remarkably decreased after 5 month of age. 3) A correlation is noted in human embryo between the functions of megakaryocytes and erythropoiesis in the spleen, a rise and fall of the one being accompanied by the other. 4) In a patient with osteomyelofibrosis, megakaryocytes found in the spleen show a remarkable decrease in the functions. en-copyright= kn-copyright= en-aut-name=HanzawaAtsumasa en-aut-sei=Hanzawa en-aut-mei=Atsumasa kn-aut-name=半澤敦正 kn-aut-sei=半澤 kn-aut-mei=敦正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=11-12 article-no= start-page=1001 end-page=1007 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Three cases of WPW syndrome kn-title=WPW症候群の三例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Three cases of WPW syndrome were reported. One was A-type and other two were B-type. In one of B-type supraventricular tachycardia was seen In E. K. G.. In another one of B-type, WPW was converted into normal pattern by administration of procaine amide. en-copyright= kn-copyright= en-aut-name=HaraokaSyoichi en-aut-sei=Haraoka en-aut-mei=Syoichi kn-aut-name=原岡昭一 kn-aut-sei=原岡 kn-aut-mei=昭一 aut-affil-num=1 ORCID= en-aut-name=HashimotoYasuharu en-aut-sei=Hashimoto en-aut-mei=Yasuharu kn-aut-name=橋本恭治 kn-aut-sei=橋本 kn-aut-mei=恭治 aut-affil-num=2 ORCID= en-aut-name=NukadaKaname en-aut-sei=Nukada en-aut-mei=Kaname kn-aut-name=額田要 kn-aut-sei=額田 kn-aut-mei=要 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1463 end-page=1469 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of Electrical Stimulation (In Vitro) on the Metabolism of the Brain Part 3. Influences of Electrical Stimulation (in vitro) on the Cerebral Transamination kn-title=電気刺戟(in vitro)の脳物質代謝におよぼす影響 第3編 電気刺戟(in vitro)の大脳トランスアミネーションにおよぼす影響 en-subtitle= kn-subtitle= en-abstract=With the use of homogenate of the brains and cerebral cortex slices obtained from albino rats, Pithecus monkey and human, the author observed the influences of electrical stimulation (in vitro) on the fransamination, and obtained the following results. 1. In the case of albino rat cerebrum the electrical stimulation inhibited the synthesis of glutamic acid from the aspatic acid 14.6 per cent with homogenate and 9.6 per cent with slices. Namely, the rate of such inhibition seems to he greater in the case of homogenate than in the case of slices. In addition, in the alanine series ne marked changes could be recognired but in GABA series all tended to receive a slight inhibitory effect. In all cases, however, the rate of reactivity is diminished more with slices than with homogenates. 2. In the case of the cerebral cortex homogenate of monkey, the electrical stimulation inhibited the glutamic and production in the aspartic acid seriet about 11 per cent on the average. In the case of the normal human cerebral cortex slices, the electrical stimulation accelerated the glutamic acid production about 11.3 per cent on the average, while in the case of atrophic human cerebral cortex homogenate hardly any changes could be recognized. In comparing the rats of reactivity in the case of the normal human cerebral cortex slices it is about 20 per cent higher both in the control group and experimental group than in the case of the slices of albino rats. In the cisa of the atrophic human cerebral cortex homogenate the reactivity was slightly lower than in the case of albino rats. kn-abstract=1) ダイコクネズミ,タイワンザル,ヒト脳の大脳ホモジネートおよび大脳皮質切片を用いて電気刺戟(in vitro)のトランスアミネーションにおよぼす影響をみた. 2) ダイコクネズミ大脳においてはAsGT活性は電気刺戟によつてホモジネートでは14.6%切片では9.6%阻害された.すなわちホモジネートの方が切片より阻害率は著明なようであつた.またAIGT活性は電気刺戟によつてホモジネート,切片とも著変なく,γAGT活性は電気刺戟によつてホモジネート,切片とも阻害傾向を示した.そこでAIGTは酵素系が異なるためではないかと推論した.また反応率はいづれの場合も切片の方がホモジネートより減少していた. 3) タイワンザル大脳皮質ホモジネートにおいてはAsGT活性は電気刺戟によつて平均約11%阻害された.またヒト健常大脳皮質切片においてはAsGT活性は電気刺戟によつて平均約11.3%の促進をみ,ヒト萎縮大脳皮質ホモジネートにおいては殆ど変化をみなかつた.また反応率を比較するとヒト健常大脳皮質切片ではダイコクネズミの切片の場合に比し対照時,刺戟時ともに約20%高く,ヒト萎縮大脳皮質ホモジネートではダイコクネズミのそれに比しやや低い値を示した.すなわち萎縮脳のAsGT活性の低下が考えられる. en-copyright= kn-copyright= en-aut-name=KumashiroHisashi en-aut-sei=Kumashiro en-aut-mei=Hisashi kn-aut-name=熊代永 kn-aut-sei=熊代 kn-aut-mei=永 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=913 end-page=921 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Viral Tumors cultivated in the embryonated Egg Part 1. Cultivation of mouse leukemia and mammary cancer in the embryonated egg kn-title=ウイルス性腫瘍の発育鶏卵内培養に関する研究 第1編 マウス白血病並びに乳癌組織の発育鶏卵内培養 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The splenic tissue of C58 strain mice with myelogenous or lymphocytic leukemia, and mammary cancer tissue of C3H strain mice were transplanted on the chorio allantoic membrane, in the allantoic cavity and in the yolk sac of embryonated eggs. Observations on the growth of the transplanted tumors and their influences on the embryos have provided the following results. I) Transplantation on the chorio-allantoic membrane. In the case of myelogenous leukemia and mammary cancer, growth of the transplanted tissue and a reactive response of various kinds of host cells in the surrounding chorio-allantoic membrane were observed. While these changes were slight in the ease of lymphocytic leukemia. The transplanted splenic tissue of myelogenous leukemia was successfully back-transplantable after five days' cultivation in the heterologous host. As controls, normal splenic tissue of C58 strain mice were similarly transplanted, but soon regressed in the course of the cultivation, 2) Transplantation in the allantoic cavity. Grossly and histologically, no signficant changes were observed in all cases. 3) Transplantation in the volk sac. The chick embryos died in 100% of cases in the transplantation of myelogenous leukemia and mammary cancer. On the other hand, the death rate was reduced to 50% in the case of lymphocytic leukemia. In the case of mammary cancer some localized necrosis was observed in the liver of the embryos. en-copyright= kn-copyright= en-aut-name=IshihamaShinzi en-aut-sei=Ishihama en-aut-mei=Shinzi kn-aut-name=石濱真治 kn-aut-sei=石濱 kn-aut-mei=真治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1471 end-page=1477 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of Electrical Stimulation (In Vitro) on the Metabolism of the Brain Part 4. Influences of Electrical Stimulation (in vitro) on Amino-N of the Cerebrum kn-title=電気刺戟(in vitro)の脳物質代謝におよぼす影響 第4編 電気刺戟(in vifro)の大脳アミノ窒素におよぼす影響 en-subtitle= kn-subtitle= en-abstract=1. By incubating the cerebral cortex slices of albino rats under aerobic and anaerobic conditions both with glucose and without any substrate, the author assayed amino-N in the suspension of the carebral cortex slices under electrical stimulation by the modified ninhydrin method. 2. In the case of the incubation under aerobic condition without substrate, amino-N tends to decrease by the electrical stimulation at 60 and 120 minutes of incubation, while in the control with glucose before electrical stimulation it is typical that the value of amino-N is already markedly low, but when it is stimulated by electricity, it conversely tends to increase. 3. In the case of anaerobic condition with or without substrate, in both cases 60 minutes afterward amino-N tends to show a slight decrease by the electrical stimulation. 4. The control values of amino-N without electrical stimulation both under the anaerobic condtions and under the aerobic condition without substrate take approximately the same course with lapse of time, and the value at 60 minutes of incubation is greater than that at 30 minutes. This increasing tendency along with the lapse of time is, however, suppressed when incubated under aerobic condition with glucose. kn-abstract=1) ダイコクネズミ大脳皮質切片を好気的および嫌気的条件下でインクブイトし.それぞれについて基質なく.およびブドウ糖基質のもとの電気刺戟時の浮游液中のアミノ窒素量をニンヒドリン改良法により測定した. 2) 好気的で基質のない場合はインクベイト60分. 120分においてアミノ窒素は電気刺戟によつて減少傾向を示し.ブドウ糖基質の場合は.電気刺戟を加えない対照値のアミノ窒素がすでに著明な低値を示し,特異的であり.これに電気刺戟を加えると逆にアミノ窒素は増加傾向を示した. 3) 嫌気的では基質なし.およびブドウ糖基質.いづれも60分後においてアミノ窒素は電気刺戟によつて多少の減少傾向を示した. 4) 電気刺戟を加えない対照値アミノ窒素は嫌気的.および好気的基質なしの条件下では大体同様の時間的経過を示し. 30分値より60分値の方が増加していた.そしてこの時間的増加傾向は好気的.ブドウ糖基質の条件下では抑制された. en-copyright= kn-copyright= en-aut-name=KumashiroHisashi en-aut-sei=Kumashiro en-aut-mei=Hisashi kn-aut-name=熊代永 kn-aut-sei=熊代 kn-aut-mei=永 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1479 end-page=1493 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Lymph-Node Tissue Culture Part 1. Effects of Various media on the Tissue Culture of Normal Rabbit Lymph Node, and a Comparative Study on the Tissue Culture of Non-Pathologic and Pathologic Human Lymph Nodes kn-title=淋巴腺組織培養に関する研究 第1編 各種培地が健康家兎淋巴腺組織培養に及ぼす影響並に人非病的淋巴腺と各種疾患々者淋巴腺組織培養について en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the lymph-node tissue culture with cover-slip generally the classical media and culture technics have been used in the past. The author studied various methods of tissue culture as well as media and also applied these technics to clinic, and obtained the following results. 1. As for the cell growth (relative growth rate, the wandering velocity of lymphocytes, and the cell density) the slide with a hollow method is beat in the tissue culture by the coverslip methods, and chick embryo juice mixed with blood plasma is good in the media. As for the cell observation the simplified culture method devised in our laboratory is convenient. By Unno's method a fairly good results can be obtained for the vital observation of cells and for the cell growth. 2. In the experiments of adding various substances to the media of chick embryo juice mixed with blood plasma, utilizing the Unno's method, the author studied the effects of these substances on the cell growth. When vitamin B(12) or estradiol is added, the result in each case is better than the control (added with Ringer'a solution), and when vitamin B(1), C, Thyradin, spleen extract, or extract of lymph node are added, the results do not differ much from that of control. With the addition of ACTH the result is inferior to that of the control. 3. The result of the tissue culture of non-pathologic human lymph nodes is about the same as in the case of the tissue culture of normal rabbit lymph nodes. In the lymph-node tissue culture in a case of lymphadenitis simplex the result is far superior to that of nonpatholcgic human lymph node, and in the lymphnode tissue culture in the case of paticnts with reticulosarcoma, Hodgkin's disease, tuberculous lymph-node inflammation and cancer metastasis, the results are mostly poor. en-copyright= kn-copyright= en-aut-name=KobayashiTeruo en-aut-sei=Kobayashi en-aut-mei=Teruo kn-aut-name=小林照雄 kn-aut-sei=小林 kn-aut-mei=照雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=923 end-page=934 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Viral Tumors cultivated in the embryonated Egg Part U. Cultivation of Viral materials isolated from mouse leukemia and mammary cancer kn-title=ウイルス性腫瘍の発育鶏卵内培養に関する研究 第2編 マウス白血病並びに乳癌より得られたウイルス材料の発育鶏卵内培養 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The viral materials isolated from the spleen of C58 strain mice with myelogenous and lymphocytic leukemia were inoculated on the chorio-allantoic membrane, in the allantoic cavity and in the yolk sac of embryonated eggs. Purification of the viral materials was done by filtration through Berkefeld N filters or emulsification with fluorocarbon. From the observations on the changes of the chorio-allantoic membrane and on the influence of the inoculation to chick embryos, the following results are obtained. 1) Inoculation on the chorio-allantoic membrane. Inoculation of the filtered viral materials caused slight thickning, hyperemia, opacities and edema of the inoculated areas of the chorio-allantoic membrane. but no changes were observed in other embryonic organs. Histologically, the chorio-allantoic mambrane showed proliferation of fibroblasts and epithelial cells and infiltration of monocytoid cells and eosinophils in the interstitial tissue. In the inoculation of the fluorocarbon-purified viral materials from myelogenous and lymphocytic leukemia, the changes of the chorioallantoic membrane were almost the same as findings described above. But in the case of mammary cancer, changes such as thickning, opacities, hyperemia and edema of the inoculated areas of the chorioallantoic membrane were more remarkable and sometimes hemorrhages and tumor-like nodular swellings were also observed. Histologically, proliferation of epithelial cells, fibroblasts and infiltration of eosinophils, lymphoid and monocytoid cells were much more prominent. No pathologic changes of other embryonic organs were observed following inocuration of the viral materials isolated by either method. 2) Inoculation in the allantoic cavity. In all cases, no significant organ changes were observed and no death of the embryos occurred. 3) Inoculation in the yolk sac. Inoculation of the filtered viral materials caused 100 % desth of the embryos by the ninth day after inoculation in the case of myelogenous leukemia, by the twelfth day in lymphocytic lukemia and by the fifth day in mammary cancer. On the other hand, in the inoculation of the fluorocarbon-purified viral materials, 100 % mortality occurred by the fifth day in myelogenous leukemia and mammary cancer and by the ninth day in lymphocytic leukemia. These varied experimental results are considered to be related to the differences in strains and virulencies of the viruses. en-copyright= kn-copyright= en-aut-name=IshihamaShinzi en-aut-sei=Ishihama en-aut-mei=Shinzi kn-aut-name=石濱真治 kn-aut-sei=石濱 kn-aut-mei=真治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=935 end-page=942 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Easily Split Off Blood Iron by Radioactive Iron Part 1. The Influences of CO and Reducing Agents on the Yield of Easily Split off Blood Iron in vitro kn-title=放射性鉄による易分離鉄の研究 第1編 赤血球内易分離鉄に対するCO並びに還元剤の鉄遊離抑制作用について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Fe(59)-radioactivities in easily split off iron fraction (E S Fe(59)) of the rabbit erythrocytes labeled with Fe(59) were determined respectively under the each condition saturated with N(2) or CO gas and added with reducing agents such as Na(2)S(2)O(4) or l-ascorbic acid. The following results were obtained. 1. There was no significant difference in the yields of E S Fe(59) between the saturation with N(2) or CO gas and the exporsure to the air. 2. E S Fe(59) under the addition with l-ascorbic acid as reducing agents (E S Fe(59)(asc)) was decreased to 35.8% of the E S Fe(59) in the case exporsed to the air (E S Fe(59)(O(2)), while E S Fe(59) under the addition with Na(2) S(2) O(4) was rather increased. 3. The yield of E S Fe(59) under the addition of l-ascorbic acid in the presence of CO gas (E S Fe(59CO+asc)) was decreased to 23.1% of E S Fe(59)(O(2)). It was thought that the difference between these two yields indicate the artificial products as a result of hemoglobin oxidation. The inhibitory capacity in isolation of iron from hemoglobin was the largest in the presence of l-ascorbic acid and N(2) gas. 4. In the hourly determinations of E S Fe(59) in rabbit erythrocytes in vivo after intravenous administration of Fe(59), E S Fe(59)(CO+asc) was found to be the maximum in the immature cells, the minimum in the mature ones and tended to increase in older ones. These results were found to be same as that of E S Fe(59)(O(2)). en-copyright= kn-copyright= en-aut-name=TabuchiHiroshi en-aut-sei=Tabuchi en-aut-mei=Hiroshi kn-aut-name=田渕博司 kn-aut-sei=田渕 kn-aut-mei=博司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1521 end-page=1544 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Effect of 2-Mercaptoethylamine on Lead Poioning -A Comparative Study on its Effect with that of Ca-EDTA Part 1. The Influence of this Drug on the Body Weight and Survival of Mice and also on the Blood Picture in Rats kn-title=鉛中毒に及ぼす2-Mercaptoethylamineの効果に関する実験的研究,Ca-EDTAの効果との比較について 第1編 マウス体重,マウス生存率並びにラット体重及び血液所見に及ぼす効果について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The present experiment was conducted in order to study the preventive and therapeutic effects of 2-mercaptoethylamine (MEA) on lead poisoning. By inducing experimental lead poisoning in mice and rats with lead, the author investigated the effects of MEA on the body weight and survival of mice and on the body weight and the blood picture of rate similarly treated, and taking these effects of MEA as the criteria and comparing them with the effects of Ca-EDTA similarly administered, the author evaluated the effectiveness of MEA. The following are the results. 1. It has been found that the effects vary according to the species of animals as well as to the amount of lead given, and for the change in the body weight of mice it proved to be superior but for the changes in the survival of mice and in the body weight and blood picture of rats it was clearly inferior to those of Ca-EDTA. 2. Generally speaking, the effect of MEA is superior to Ca-EDTA for the first week after the initiation of its administration but when repeatedly given thereafter the effect of Ca-EDTA supercedes that of MEA. 3. Concerning the mechanism of the action of MEA, at present it is still in a theoretical stage and it remains a problem that requires more extensive studies before confirming its mechanism. However, a deduction may be drawn from the findings of the present experiment. Namely, it is assumed that the effect of MEA is due to some biological action other than its action of producing metal complex and its combining power lead in vivo is extremely weaker than that of Ca-EDTA so that it tends to bring about oxidative disintegration of lead-MEA complex in vivo and thus there is rather a possibility of its unfavorable effect. en-copyright= kn-copyright= en-aut-name=KurodaTakeshi en-aut-sei=Kuroda en-aut-mei=Takeshi kn-aut-name=黒田健 kn-aut-sei=黒田 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1545 end-page=1553 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Effect of 2-Mercaptoethylamine on Lead Poisoning -A Comparative Study on its Effect with that of Ca-EDTA- Part 2. Influence of the Drug on the Lead Contents in Blood and Organs of Rats and on the Amount of Lead excreted in Guinea-Pig Urine kn-title=鉛中毒に及ぼす2-Mercaptoethylamineの効果に関する実験的研究,Ca-EDTAの効果との比較について 第2編 ラット血液及び臓器内鉛量,ならびにモルモット尿中排泄鉛量に及ぼす影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the purpose of elucidation the effects of MEA on the prevention and therapy of lead poisoning, the present experiment was conducted. The author first induced lead poisoning in rats and guinea pigs by administering them lead and measured quantitatively the changes occurring in the lead contents of blood, liver, kidneys, and femur in the rats and also the lead quantity excreted in urine of the guinea pigs, after administering to these animals. In addition, by administering Ca-EDTA to similar groups of animals treated in the same manner, the author compared the changes brought about by these two drugs and thus evaluated the effects of MEA. 1. At the end of the first week after repeated administration of MEA the changes in the lead contents in blood did not differ greatly from those observed in the control group, whereas those in the group repeatedly administered with Ca-EDTA showed extensively higher value. Those in the organs mentioned above did not differ greatly from each others among these three groups. 2. The lead contents in the organs 4 weeks after repeated administration of MEA did not differ from those in the control, but the contents showed the greater value of 2-3 times than the contents in the groups of repeated administration of Ca-EDTA. 3. It has been observed that the quantity of lead excreted in urine by MEA administration increases slightly as compared with that in the control group, but this increase is far lesser than that brought about by the Ca-EDTA administration. 4. From these it has been clarified that hardly any effect of dissolution and excretion of lead outside the body can be expected by the repeated administration of MEA, and that in this respect the effect of MEA is far inferior to that of Ca-EDTA. en-copyright= kn-copyright= en-aut-name=KurodaTakeshi en-aut-sei=Kuroda en-aut-mei=Takeshi kn-aut-name=黒田健 kn-aut-sei=黒田 kn-aut-mei=健 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1555 end-page=1560 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of Unsaturated Fatty Acid Fraction (OX) extracted from the Liver of X-Irradiated Rabbit on the Activity of Succinic dehydrogenase in Subcutaneously-Transplanted Yoshida Sarcoma Cells kn-title=X線照射家兎肝より抽出せる不飽和脂肪酸分画 (OX) の筋肉内移植吉田肉腫細胞のコハク酸脱水素活性に及ぼす影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to study influences of OX on the activity of succinic dehydrogenase in Yoshida sarcoma cells transplanted intramusculrally in the albino-rat thigh, the author injected OX intra-tumorally or intravenously into tumor bearing rats and carried out biochemical and histochemical investigations. The results are as follows: 1. In the cases given direct, intratumoral injection of OX, the activity of succinic dehydrogenase in Yoshida sarcoma cells thus transplanted is decreased, and it recovers very slowly but the same activity in muscle tissues recovers more rapidly. 2. In the histochemical observations when OX is injected intratumorally, central necrosis is increased and also a marked enlargement of bionecrotic foci occurs, but in the outer-most layer colonies of proliferative cells can be recognized. 3. When OX is injected intravenously into tumor bearing rats, the activity of the dephydrogenase is rather increased in tumor tissue, and the part where such increase occurred ultimately tends to become necrotic. In addition, the author discussed briefly about the relation between these changes in the activity of dehydrogenase and OX. en-copyright= kn-copyright= en-aut-name=IguchiYoshiko en-aut-sei=Iguchi en-aut-mei=Yoshiko kn-aut-name=井口与志子 kn-aut-sei=井口 kn-aut-mei=与志子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=943 end-page=950 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Easily Split Off Blood Iron by Radioactive Iron Part 2. The Significances of Easily Split Off Blood Iron in the Immature Erythrocyte kn-title=放射性鉄による易分離鉄の研究 第2編 幼若赤血球内易分離鉄の本態について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Fe(59)-radioactivities in the both hemin iron fraction(Hemin-Fe(59)) and easily split off iron fraction (E S Fe(59)) of the rabbit erythrocyes obtained in reticulocytosis were determined respectively after incubating them with Fe(59) in vitro. On the other hand, immature rabbit erythrocytes labeled with Fe(59) in vivo were incubated in nonradioactive medium, and the same determinations as the above were carried out. The following results were obtained. 1. Reticulocytes of rabbit uptook considerably Fe(59) during incubation in vitro. 2. Fe(59) uptaken in reticulocyte were quickly utilized to the synthesis of hemin. However, Fe(59) at preceding stage of the synthesis were found to be extracted as false ealily split off iron. 3. With the incubation of reticulocytes for 5 hours in vitro, the E S Fe(59) increased after the synthesis of hemin-Fe(59). 4. In vivo, the E S Fe(59) increased in new formed labeled erythrocytes at 6 to 9 hours after intravenous administration of Fe(59), originating from hemoglobin break-down at that stage. en-copyright= kn-copyright= en-aut-name=TabuchiHiroshi en-aut-sei=Tabuchi en-aut-mei=Hiroshi kn-aut-name=田渕博司 kn-aut-sei=田渕 kn-aut-mei=博司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=5-7 article-no= start-page=1561 end-page=1567 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19600730 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Hemolytic Substance Produced at X-Ray Irradiation Part 2. Qualitative Analysis and Biological Action of the Hemolytic Substance kn-title=放射線照射時に発生する溶血性物質に就いて 第二編 溶血性物質の定性的研究並びに生物作用に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=The cause of irradiation anemia seems to lie in biological phenomena as well as in hemolytic toxin produced by X-Ray irradiation. It has been confirmed that since phospholipid fraction in vivo shows strong toxicity in direct proportion to the dose of X-rays, the actual hemolytic substance is lysolecithin. This substance is proved to give rise to marked morphological changes in hematopoietic organs, and it has also been clarified that the same substance acting on sea-urchin egg brings about a delay in egg division. However the same snbstance does not induce any striking change in the respiratory enzyme system. en-copyright= kn-copyright= en-aut-name=AkagiEiko en-aut-sei=Akagi en-aut-mei=Eiko kn-aut-name=赤木瑩子 kn-aut-sei=赤木 kn-aut-mei=瑩子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=951 end-page=958 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Easily Split Off Blood Iron by Radioactive Iron Part 3, Electrophoretic Behaviors of Easily Split Off Blood Iron kn-title=放射性鉄による易分離鉄の研究 第3編 Starch Block Electrophoresisによる血色素易分離鉄の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the purpose of clarifying the significance of E S Fe, starch block electrophoresis of rabbit hemoglobin was been carried out and the following results were obtained. 1. The hemoglobin was separated in three fractions, T, U and V. In the migration distances, these fractions corresponded to Hemoglobin A(1), A(2) and A(3) of adult hemoglobin respectively. 2. E S Fe was detected most in the fraction V (largest at mobility), while free iron in that fraction was less than the other fractions. 3. In estimating the ratio of Fe(59)-radioactivity to hemoglobin volume (mg) of the Fe(59) labeled hemoglobin solution in the each fraction eluate, it was noticed that the specific activity of the fraction V was less than those of others during 3 weeks after the administration of Fe(59), followed by a significant increase after 6 weeks. It was thought from the above that the hemoglobin in fraction V different from that in the other fractions, and that in the early stage was different from that in the later one. 4. The ratio of radioactivities in easily split off iron to that in hemoglobin iron of the same samples as the above increased markedly in the fraction V in the early stage, followed by a gradual decrease during 2 weeks and again a tendency of increase at 4 weeks later in the same fraction. 5. It was indicated from these results that the characters of the globin in new formed hemoglobin and aged one were different from that in mature one, and that this difference in the characters was resulted in an increase of E S Fe due to hemoglobin degradation. en-copyright= kn-copyright= en-aut-name=TabuchiHiroshi en-aut-sei=Tabuchi en-aut-mei=Hiroshi kn-aut-name=田渕博司 kn-aut-sei=田渕 kn-aut-mei=博司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=8-10 article-no= start-page=1581 end-page=1593 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=STUDIES ON TISSUE CULTURES OF HUMAN AND MOUSE TUMORS Part 2. Carbohyrate Metabolism of Human Cervical Carcinoma, Bashford's Mouse Carcinoma, and Normal Mouse Liver Tissue in Tissue Culture kn-title=人癌及びマウス癌組織の組織培養に関する研究 第2編 人子宮頸癌及びBashford氏マウス癌並びに正常マウス肝組織の組織培養に於ける糖代謝に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=The roller-tubo tissue cultures of human cervical carcinoma, Bashford's mouse carcinoma, and normal mouse liver tissue were performed in order to inquire into carbohydrate metabolism in the culture media. Glucose consumption, lactic acid, pyruvic acid, and α-ketoglutaric acid productions in cutlure media by human and animal tumors and by normal mouse liver tissue were estimated, and the following results have been obtained. 1. Glucose consumption and lactic acid production by human cervical carcinoma and Bashford's mouse carcinoma were in higher level than by normal mouse liver tissue. This was considered as the fact showing the high glycolysis of tumor tissues in vitro. 2. The ratios of lactic acid production/glcose consumption, pyruvic acid production/glucose consumption, α-ketoglutaric acid production/glueose consumption, in each tissue, were compared with each other. The ratio of lactic acid production/glucose consumption in every tissue turned out to be quite similar in values. But the ratios of pyruvic acid production/glucose consumption and α-ketoglutaric acid production/glucose consumption in Bashford's mouse carcinoma, were very low, about one third and one tenth of normal mouse liver tissue, respectively. In human cervical carcinoma, the ratio of pyruvic acid production/glucose consumption showed almost the same value as normal mouse liver tissue, but the ratio of α-ketoglutaric acid production/glucose consumption in human cervical carcinoma was half the value of normal mouse liver tissue. Thus pyruvic acid and α-ketoglutaric acid production, the components of tricarboyylic acid cycle, were reduced in tumor tissuen in vitro inspite of the same glucose consumption and lactic acid production as in normal mouse liver tissue in vitro. Therefore, the carbohydrate metabolism, as for the tricaroxylic acid cycle in tumor tissues, turned out to be different from normal mouse liver tissue. 3. The changes of hydrogen ion concentration in the culture media were in step with the course of tissue cultures. And the pH in tissue culture media had a correlation with the lactic acid production by tissues in vitro. But the increase in the pH was closely correlated with the lactic acid, pyruvic acid, and α-ketoglutaric acid productions by human cervical carcinoma, Bashford's mouse carcinoma, and normal mouse liver tissue in culture media. en-copyright= kn-copyright= en-aut-name=ShiraishiAkinori en-aut-sei=Shiraishi en-aut-mei=Akinori kn-aut-name=白石彰徳 kn-aut-sei=白石 kn-aut-mei=彰徳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=959 end-page=964 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=網内系機能と悪性腫瘍並びに放射線との関係に就いて 第1編 墨汁?塞に依るラッテの血液像,網内系機能並びに吉田肉腫接種後の腫瘍発育,生存率,転移形成に及ぼす影響に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=田邊正忠 kn-aut-sei=田邊 kn-aut-mei=正忠 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=8-10 article-no= start-page=1595 end-page=1607 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=STUDIES ON TISSUE CULTURES OF HUMAN AND MOUSE TUMORS Part 3. Protein Metabolism of Human Cervical Carcinoma Bashford's Mouse Carcinoma, and Normal Mouse Liver Tissue in Tissue Culture kn-title=人癌及びマウス癌組織の組織培養に関する研究 第3編 人子宮頸癌及びBashford氏マウス癌並びに正常マウス肝組織の組織培養に於ける蛋白代謝に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=The protein metabolism of human cervical carcinoma, Bashford's mouse carcinoma, and normal mouse liver tissue have been studied with special reference to the culture media, and the following results were obtained. 1. The whole protein in the culture media of human cervical carcinoma, Bashford's mouse carcinoma, and normal mouse liver tissue was estimated. And as the results it was found that with lapse of time of the culture, human cervical carcinoma and Bashford's mouse carcinoma showed a higher protein consumption than that by normal mouse liver tissue. 2. In every tissue culture albumin was increased as compared with that in the control, but there was no difference between tumor tissues and normal tissue. 3. α-globulin in the media of human cervical carcinoma had no deviation from the control. α-globulin in the media of Bashford's mouse carcinoma showed a derease when compared with that of the control on one day after tissue cnlture, but with lapse of time in tissue culture it was increased. In the culture media of normal mouse liver tissue, α-globulin showed an increase as compared with the control on one day after tissue culture, but a remarkable decrease was found on 3 days afterward. As for normal mouse liver tissue, α-globulin showed the lower value than human cervical carcinoma and Bashford's mouse carcinoma during the course of tissue cultures. 4. The remarkable increase of β-globulin in the culture media of human cervical carcinoma could be seen. In the media of Bashford's mouse carcinoma, β-globulin showed a decrease on 3 days after tissue culture. β-globulin in the culture media of normal mouse liver tissue revealed an increase on one day after tissue culture, but on third day Bashford's mouse carcinoma and normal mouse liver tissue presented almost the same value. And both tissues showed an increase on five days cfter the tissue culture. 5. γ-globulin in every tissue culture was found to show a decrease as compared with the control along with the lapse of culture time. And in this respect no difference was found between tumor tissues and normal tissue. en-copyright= kn-copyright= en-aut-name=ShiraishiAkinori en-aut-sei=Shiraishi en-aut-mei=Akinori kn-aut-name=白石彰徳 kn-aut-sei=白石 kn-aut-mei=彰徳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=10 article-no= start-page=965 end-page=979 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Relations between Reticulo-endothelial System, Tumor and X-Rays kn-title=網内系機能と悪性腫瘍並びに放射線との関係に就いて 第2編 実験腫瘍(吉田肉腫),網内系,放射線との相関に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=Vol. T The effect given to the blood picture and the function of the reticulo-endothelial system using reticulo-endothelial system blocked by the Indian ink method and also the tumor growth, survival rates and metastasis after transplanting Yoshida sarcoma cells intramusclarlly in the albino-rat thigh were examined. Experiment was done to find out the relations between the reticulo-endothelial system and the latter, which the results were as follows: 1) As formerly reported, the reticulo-endothelial system blocked by the Indian ink method showed anaemia by a certain quantity of ink but it passed by and restored gradually. It showed parallel relation with the function of the reticulo-endothelial system. 2) If the ink was small in quantity, it did not give much effects to tumor growth though the function of the reticulo-endothelial system was low. 3) The reticulo-endothelial system blocked by the Indian ink method had a connection with the growth of tumor to some extent and gave pictures which accelerated its growth. And stromal reaction near the tumor was weak. 4) Using the reticulo-endothelial system blocked by the Indian ink method, the appearance of the reticulo-endothelial cells in the tumor tissue was less compared with the control. Vol. U Chapter 1 To prove the reaction on the X-rays of the reticulo-endothelial system and tumor growths, the author made an experiment based on the idea of tumor-host relationship. X-rays, 600r a day continuing 5 days totalling 3000r, were irradiated into the tumor bed, albino-rat thigh, and then Yoshida sarcoma cells were transplanted on the irradiated part. The influence against tumor growth, survival rates and metastasis were examined and the effects were found as follows: 1) Compared with the control, the tumor growths were restrained in the order of transplanted groups of the next day after irradiation, transplanted groups of 10 days after irradiation, and transplanted groups of 30 days after irradiation. With the survival rates, life extension could be recognized in the same order. 2) Stromal reaction could be strongly found in pre-irradiated groups, especially in these being transplanted the next day. Reticulo-endothelial cells could be found many compared with the control. Above all, it could be presumed that in case of preoperative irradiation, the part of reticulo-endothelial cells which has not been infiltrated by tumor cells shows protection system by stromal reaction. Chapter 2 When the tumor which was transplanted by Yoshida sarcoma cells became a regular induration; the size, the rise and fall, and the survival rates were examined by irradiating 300r a day for 10 days totalling 3000r. The effect showed that when the function of the reticulo-endothelial system which is one of the living body reaction was irradiated after it was restrained, the irradiation effect was less than the non-treated group. Consequently if the function of the reticulo-endothelial system would be irradiated after it was accelerated, it would obtain satisfactory result to medical treatments. en-copyright= kn-copyright= en-aut-name=TanabeMasatada en-aut-sei=Tanabe en-aut-mei=Masatada kn-aut-name=田邊正忠 kn-aut-sei=田邊 kn-aut-mei=正忠 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=8-10 article-no= start-page=1609 end-page=1613 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of High Hydrostatic Pressure on Smooth Muscle Part T. On the longitudinal muscle of frog intestine kn-title=平滑筋に及ぼす高水圧の影響 其の一 蛙腸管縦走筋について en-subtitle= kn-subtitle= en-abstract= kn-abstract=When high hydrostatic pressure (50 to 500 kg/?) was applied to isolated longitudinal muscle strip (10 to 15 mm long, 2 to 3 mm wide) of frog intestine hanging in Ringer's solution, following changes of its length and rhythmical movement were observed. 1) Under high hydrostatic pressure up to 100 kg/? the rhythmical movement of the strip is accelerated in frequency and tonus effectively, depending on neurogenic nature, and at 300 to 500 kg/? it weakens or disappears. 2) When the pressure of about 300 to 500 kg/? is applied to the muscle strip, it lengthens quickly at first and then conversely shortens gradually after a certain limit of extension, and again the strip contracts rapidly but temporarily and then relaxes slowly. 3) These lengthening and subsequent shortening of the strip under high hydrostatic pressure of 300-500 kg/? seem to to of myogenic nature and not of neurogenic nature. en-copyright= kn-copyright= en-aut-name=MikiHukuziro en-aut-sei=Miki en-aut-mei=Hukuziro kn-aut-name=三木福治郎 kn-aut-sei=三木 kn-aut-mei=福治郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一生理学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=8-10 article-no= start-page=1615 end-page=1621 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of High Hydrostatic Pressure on Smooth Muscle Part U. Effect of some drugs on the longitudinal muscle of frog intestine kn-title=平滑筋に及ぼす高水圧の影響 其の二 蛙腸管縦走筋に及ぼす諸種薬品作用について en-subtitle= kn-subtitle= en-abstract= kn-abstract=High hydrostatic pressure (50 to 500 kg/?) was applied to isolated longitudinal muscle strip (10 to 15 mm long, 2 to 3 mm wide) of frog intestine immersed in Ringer's solution containing some drugs, and from the observation of changes of the tonus and rhythmical movement of the preparation following results were obtained. 1) When a drug acts upon the strip during compression, such as magnesium sulfate, barium chloride, acetylcholine or atropine sulfate, the changes on the strip result in algebraic summation of the pressure- and drug-effects. But the action of adrenaline chloride on the strip is reversed under high hydrostatic pressure. Namely, the movement of the strip inhibited by adrenaline or pressure respectively, but it is augumented when the pressure is applied on the strip immersed in the adrenaline-Ringer's solution. 2) The stimulative effect on the muscle strip under high hydrostatic pressure up to 100 kg/? is of neurogenic nature. But under pressure from 300 to 500 kg/? the first instaneous lengthening of the strip and successive slow shortening are observed and this effect is of myogenic nature. 3) The temporary contraction of the strip immediately after decompression may be considered as an adaptive process in biological phenomenon. en-copyright= kn-copyright= en-aut-name=MikiHukuziro en-aut-sei=Miki en-aut-mei=Hukuziro kn-aut-name=三木福治郎 kn-aut-sei=三木 kn-aut-mei=福治郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一生理学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=11-12 article-no= start-page=981 end-page=989 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Tissue Culture of Liver Part 1. On the Composition of Culture Medium in the Roller Tube Method of Rabbit Liver kn-title=肝臓組織培養に関する研究 第1編 廻転培養法による家兎肝臓の至適培養液の組成に就いて en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author has conducted tissue culture of rabbit liver by roller tube method. The pH changes in culture media were estimated. The rise of hydrogen ion concentration in the course of culture was parallel to the rate of cell increase. The most appropriate medium has been a fluid medium consisting of 70% Hank's solution, 20% rabbit serum and 10% chick embryo extract. Without chick embryo extract the cells found to grow do not easily grow out, but in its high concentration fibroblasts grow very well. Amoung the various sera rabbit serum is the most accelarative to the growth of liver cells. Human serum is second and horse serum worse in promoting activity. The ascites with stomach cancer almost dose not show promoting activity to liver cells. In addition of small amount of rabbit serum to the medium liver cells exhibit an excellent growth, but the more the serum becomes concentrated, the more fibroblasts grow. en-copyright= kn-copyright= en-aut-name=AsanoKenwo en-aut-sei=Asano en-aut-mei=Kenwo kn-aut-name=浅野健夫 kn-aut-sei=浅野 kn-aut-mei=健夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=8-10 article-no= start-page=1623 end-page=1630 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of High Hydrostatic Pressure on Smooth Muscle Part V. On the pupillary muscle of frog kn-title=平滑筋に及ぼす高水圧の影響 其の三 蛙の瞳孔筋について en-subtitle= kn-subtitle= en-abstract= kn-abstract=High hydrostatic pressure (500 kg/? and 1,000 kg/?) was applied to an enucleated eyeball and eyeballs of the decapitated frog head, which were suspended in Ringer's solution. Next, some autonomic drugs were added to the solution to make them act on the eyeballs before, during or after compession. By observing the pupillary changes, the following results were obtained. 1) After decompression the pupil becomes wide at first and then narrow. But the miosis after decompression does not occur in the same manner in the enucleated eye as with those of the decapitated head. 2) The effects of autonomic drugs also vary according to the difference whether the eye has connection with the central nervous system or not. 3) These facts appear to prove that high hydrostatic pressure has marked influence on the central nervous system. Its sensitivity to autonomic drugs is remarkably raised by high pressure. en-copyright= kn-copyright= en-aut-name=MikiHukuziro en-aut-sei=Miki en-aut-mei=Hukuziro kn-aut-name=三木福治郎 kn-aut-sei=三木 kn-aut-mei=福治郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一生理学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=8-10 article-no= start-page=1631 end-page=1634 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Influences of Composition of Culturing Medea to Immuno-logical Properties of Nucleic Acid and Relative Substances of Microorganisms kn-title=菌体核酸系物質の免液学的性状とこれに対する培地組成の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Hemolytic and precipitin reaction of nucleic acid and nucloprotein fractions from Sh. flexneri 2 a and St. aureus were studied and the results as follow are obtained. 1 In these microorganisms, hemolytic reactions of nucleic acid fractions were negative, and precipitin reactions were positive. 2 Nucleoprotein fraction from Sh. flexneri 2 a grown on glucose added medea showed a stronger positive hemolytic reaction, whereas that from St. aureus tended to negative. 3 Nucleic acid fractions from these microorganisms grown on Fe?? deficient medea by adding α, α'-dipyridyl showed a negative hemolytic reactions. 4 From these results it could be seen that the immunological properties of nucleic acid or nucleoprotein fractions were affected by the composition of culturing medea. en-copyright= kn-copyright= en-aut-name=AkiyamaKenji en-aut-sei=Akiyama en-aut-mei=Kenji kn-aut-name=秋山健二 kn-aut-sei=秋山 kn-aut-mei=健二 aut-affil-num=1 ORCID= en-aut-name=NishiiEmiko en-aut-sei=Nishii en-aut-mei=Emiko kn-aut-name=西井笑美子 kn-aut-sei=西井 kn-aut-mei=笑美子 aut-affil-num=2 ORCID= en-aut-name=NakaoYasuo en-aut-sei=Nakao en-aut-mei=Yasuo kn-aut-name=中尾保郎 kn-aut-sei=中尾 kn-aut-mei=保郎 aut-affil-num=3 ORCID= en-aut-name=KazitaniHideya en-aut-sei=Kazitani en-aut-mei=Hideya kn-aut-name=梶谷英也 kn-aut-sei=梶谷 kn-aut-mei=英也 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=8-10 article-no= start-page=1635 end-page=1641 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Fffect of High Hydrostatic Pressure on Cell Division kn-title=細胞分裂に及ぼす高水圧の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to study the influence of pressure effects on the cell division of sea urchin eggs we have performed a series of experiments to enable us to understand the meaning and the importance of morphogenesis of the embryo. Sea urchin eggs used are of Temnopleurus tereumatics, in the stages of unfertilization to early blastulae. The experimental results can be summarized as follows. 1) In unfertilized eggs the elevation of fertilization membrane is delayed by high pressure of 300 kg/? applied for 15 minutes. The delay is in proportion to the pressure intensity and duration. Neverthless, furrowing process of the egg does proceed after the pressure is withdrawn. 2) Likewise, in fertilized eggs, the furrowing are retarded under high pressure, in fertilized eggs, the furrowing are retarded under high pressure, in proportion to the pressure intensity and duoration. In most cases, however, the rate of the cell division catches up with that of the control before reaching the stages of bastulae. 3) The deformities of pluteus can be observed in applying the pressure neither to unfertilized, nor to fertilized eggs in all stages. en-copyright= kn-copyright= en-aut-name=YasudaHirosi en-aut-sei=Yasuda en-aut-mei=Hirosi kn-aut-name=安田浩士 kn-aut-sei=安田 kn-aut-mei=浩士 aut-affil-num=1 ORCID= en-aut-name=MurakamiTetuhide en-aut-sei=Murakami en-aut-mei=Tetuhide kn-aut-name=村上哲英 kn-aut-sei=村上 kn-aut-mei=哲英 aut-affil-num=2 ORCID= en-aut-name=MikiHukuziro en-aut-sei=Miki en-aut-mei=Hukuziro kn-aut-name=三木福治郎 kn-aut-sei=三木 kn-aut-mei=福治郎 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一生理学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一生理学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一生理学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=8-10 article-no= start-page=1651 end-page=1663 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on the Relation Belation Between Thyroid Function and Tumor Growth Report 1 The Effect of Pretiron (TSH) on the Tumor Growth and Transplantation kn-title=甲状腺機能の腫瘍増殖に及ぼす影響に関する実験的研究 第1報 腫瘍の増殖並びに移植に及ぼすプレチロン(甲状腺刺戟ホルモン)の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this experiment, the authors obserbed the effect of Pretiron (TSH) on the transplantation and growth of three kinds of trnsplantable tumors of animals. 1) Ehrlich Ascites Tumor Mice weighing approximately 20 g were used. All mice were transplanted with Ehrlich Ascites Tumor intraabdominally. Pretiron (TSH) was intramuscularly injected daily for the period of 23 days, beginning 3 days prior to the transplantation of tumor. In the Pretiron (TSH) treated group, the growth of free ascites tumor cells was markedly inhibited and the survival days of these mice were prolonged (20-50 days). In the ascites of this group of mice, the infiltration of numerous lymphocyte-like cells was recognized. On the other hand, the survival days of the control group of mice were less than 20 days and the marked growth of free ascites tumor cells was obserbed. 2) Fibrosarcoma 58. The growth of transplanted tumor in the Pretiron (TSH) treated group is moderately inhibited. In the tumor tissue of Pretiron treated group, the more maked infiltration of lymphocyte-like cells was seen than iu the control group. 3) Mammary Carcinoma in R Strin of Mice The growh of transplanted tumors of Pretiron (TSH) treated group was markedly inhibited and thelmajority of these tumors disappeared. Histologicaly, numerous lymphocyte-like cells was found to infiltrating in the stroma of the tumor tissues. On the contrary, in the control group, the transplanted tumors grew well in all mice. From these findings it is concluded that Pretiron (TSH) has an inhibitory action on these tumors. Although the mechanism of antitumor action of Pretiron (TSH) is unknown, it is interestinh that Pretiron (TSH) promotes the infiltration of lymphocyte-like cells in tumor tissues as obserbed in this experiment. en-copyright= kn-copyright= en-aut-name=SatoYasuo en-aut-sei=Sato en-aut-mei=Yasuo kn-aut-name=佐藤泰雄 kn-aut-sei=佐藤 kn-aut-mei=泰雄 aut-affil-num=1 ORCID= en-aut-name=KiyamaTakashi en-aut-sei=Kiyama en-aut-mei=Takashi kn-aut-name=木山敞 kn-aut-sei=木山 kn-aut-mei=敞 aut-affil-num=2 ORCID= en-aut-name=MatsuraUmeharu en-aut-sei=Matsura en-aut-mei=Umeharu kn-aut-name=松浦梅春 kn-aut-sei=松浦 kn-aut-mei=梅春 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部砂田外科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=11-12 article-no= start-page=1009 end-page=1020 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Rickettsia tsutsugamushi in tissue cultures. (T) Sensitivity to R. tsutugamushi Infections in several kinds of cultured cells kn-title=R. tsutsugamushiの組織培養に関する研究 第1編 各種培養細胞系に対するR. tsutsugamushiの感受性について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Author did the experiments of tissue cultures infected with the agents (mitani strain) of Umayado Diseases, and got the results as follows: 1) Author did the tests of sensitivity to R. tsutsugamushi infection in the established culture-cells and knew they have the big spectrum of infection to the cells like FL cells, H(E)L(A) cells and liver cells (Chang). They showed the specific cytopathic effects (CPE) with multiplication of R. tautsugamushi also. 2) It was possible to get the positive results in the infection tests to mouse with the agents which passaged in FL cells, and it is possible to do the quantitative tests of R. tsutsugamushi by inspecting of CPE as an infection indicators. These specific CPE supported to know the process of infection and growth of R. tsutsugamushi. 3) Growth process of R. tsutsugamushi is very similar with the bacterial cell division system (binary fission) and is very slow in time and specific in morphology. en-copyright= kn-copyright= en-aut-name=MizuharaYoshimasa en-aut-sei=Mizuhara en-aut-mei=Yoshimasa kn-aut-name=水原良昌 kn-aut-sei=水原 kn-aut-mei=良昌 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=11-12 article-no= start-page=1893 end-page=1899 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Two Cases of Complete Atrioventricular Block kn-title=房室完全ブロックの2例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Two cases of complete atrioventricular block due to hypertensive cardiovascular disease were studied. The one was 68-year-old male in whom complete atrioventricular block with automaticity of His's bundle and ventricle was noted. The other was 81-year-old male in whom complete atrioventricular block with ventricular capture was noted. Some considerations on the causes and clinical manifestations of complete atrioventricular block were made. en-copyright= kn-copyright= en-aut-name=SuezawaYasuko en-aut-sei=Suezawa en-aut-mei=Yasuko kn-aut-name=末沢泰子 kn-aut-sei=末沢 kn-aut-mei=泰子 aut-affil-num=1 ORCID= en-aut-name=IshidaHidemasa en-aut-sei=Ishida en-aut-mei=Hidemasa kn-aut-name=石田秀雅 kn-aut-sei=石田 kn-aut-mei=秀雅 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=大阪医科大学病理学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=11-12 article-no= start-page=1021 end-page=1027 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Rickettsia tsutsugamushi in tissue cultures (U) Studies on growth process of R. tsutsugamushi in FL cells. kn-title=R. tsutsugamushiの組織培養に関する研究 第2編 FL細胞を用いたR. t.の増殖過程に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Author mentioned the results of several problems on adsorption, growth and morphology of vegetative forms of R. tsutsugamushi in FL cells as the host cells of them in vitro. The process of growth of R. tsutsugamnshi was different from the process of growth of viruses. Binary fission system of R. tsutsugamushi were suggested in growth process of them from the results of growth curve and morphology of them. Also author knew that there are the release of rickettsia from the infected cells and the infection of rickettsia. from cell to cell on some periods of infection process. en-copyright= kn-copyright= en-aut-name=MizuharaYoshimasa en-aut-sei=Mizuhara en-aut-mei=Yoshimasa kn-aut-name=水原良昌 kn-aut-sei=水原 kn-aut-mei=良昌 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=8-10 article-no= start-page=1665 end-page=1678 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=膵内分泌の胃潰瘍発生因子に関する実験的研究 第1編 インシュリン潰瘍について en-subtitle= kn-subtitle= en-abstract= kn-abstract=It has been suggested, since many years, that endocrine function of the pancreas may be related to the peptic ulceration of the stomach. There has been, however, no unanimous opinion on this item. To clarify this problem, the author investigated, from several points of view, the changes in gastric mucosa following administration of NPH-Insulin to the rat. By the intramuscular administration of NPH-Insulin hemorrhagic erosion of the gastric mucosa, instead of ulceration, was observed especially on the corpus of the glandular stomach. The occurrence of erosion was related to the severity of hypoglycemia produced by the Insulin and the rats showing erosion of the gastric mucosa were always associated with hypoglycemic shock. In the rats with gastric erosion weight of their adrenal glands was increased, concentration of K in sera was decreased, and concentration of Na in sera was increased. The occurrence of erosion in the gastric mucosa following administration of NPH-Insulin was completely hindered by vagotomy and was slightly depressed by administration of Chlorpromazin and of Dietazin. In the adrenaletomized rat, the erosion was more marked even after administration of small dosis of NPH-Insulin, and was not hindered by vagotomy. Gastric secretory function in rat with erosion of the gastric mucosa was depressed by administration of the Insulin. In the histological study of the stomach, contraction of the arteries in the submucosa, dilatation and stagnation of the veins in the submucosa and the mucosa were observed. The erosion did not develop to chronic ulcer even after repeated administration of the Insulin. It was, therefore, confirmed that circulatory disturbance in the gabtric mucosa caused by vascular change which was produced by means of vagal stimulation played a main role on the occurrence of erosion in the administration of the Insulin, and was also surmized that the reduced resistance of the gastric mucosa caused by hypoglycemia promoted formation of erosion. en-copyright= kn-copyright= en-aut-name=MorimotoKohei en-aut-sei=Morimoto en-aut-mei=Kohei kn-aut-name=森本浩平 kn-aut-sei=森本 kn-aut-mei=浩平 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=11-12 article-no= start-page=1029 end-page=1034 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Rickettsia tsutsugamushi in tissue cultures (V) On the general characteristics of R. tsutsugamushi passaged on FL cell system kn-title=R. tsutsugamushiの組織培養に関する研究 第3編 FL細胞累代R. t.の一般性状について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The general characteritics of R. tsutsugamushi which passaged on cells of tissue culture were always constant and showed the same characters with original physical characteristics of rickettsia. Gradually, growth of intracellular rickettsia was observed clearly and CPE was kept constantlly after passages in long period. Such CPE by R. tsutsugamushi was a infection indicator and showed a specific infection system. en-copyright= kn-copyright= en-aut-name=MizuharaYoshimasa en-aut-sei=Mizuhara en-aut-mei=Yoshimasa kn-aut-name=水原良昌 kn-aut-sei=水原 kn-aut-mei=良昌 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡大医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=8-10 article-no= start-page=1679 end-page=1685 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Study on the Ulcerogenic Factors of Pancreatic Endocrine Function” Part II. Effect of Alloxan-Induced Hyperglycemia on Ulceration kn-title=膵内分泌の胃潰瘍発生因子に関する実験的研究 第2編 アロキサン糖尿病と潰瘍の関係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It was discussed, in part I, that endocrine function of the pancreas may be related to peptic ulceration of the stomach, though many problems on this item remain unknown. To clarify the influence of hyperglycemia induced by damage of the pancreas on the ulceration of the stomach, the author studied, in this part, changes in gastric mucosa and the secretory function of the stomach in Alloxan-diabetic rat. The incidence of the gastric erosion in Alloxan-diabetic rat following administration of NPH Insulin was equal to that in the non-diabetic. Gastric secretory function in Heidenhain's pouch of dog was elevated in all cases on the day of administration of Alloxan, and in half of the cases the function remained elevated during the course of diabetic state. In Alloxandiabetic rat, however, gastric secretory function was depressed and the depression was much more remarkable in the cases in which adrenalectomy was added. No ulcer was observed in gastric mucosa of Alloxan-diabetic rat. It was, therefore, surmized that the hyperglycemia induced by Alloxan was not related to the ulceration of the stomach. en-copyright= kn-copyright= en-aut-name=MorimotoKohei en-aut-sei=Morimoto en-aut-mei=Kohei kn-aut-name=森本浩平 kn-aut-sei=森本 kn-aut-mei=浩平 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部砂田外科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=11-12 article-no= start-page=1035 end-page=1067 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Disorders in Vascular Factor in Reference to Hemorrhagic Tendency Following Extracorporeal Circulation kn-title=体外循環にともなう出血傾向―とくに血管因子障害に関する臨床的実験的研究― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bleeding tendency following extracorporeal Bleeding tendency following extracorporeal circulation was studied mainly in the view of vascular disturbances. 1) Pre-and post-operative changes in hemostatic mechanism were investigated in 61 patients, who underwent open heart surgery under extracorporeal circulation with Kay-Anderson heart lung machine. After perfusion the most noticeable and constant changes in hemostatic mechanism were prolongation of bleeding time, decreased capillary resistance, increased capillary permeability and reduction of platelet count which showed vascular disturbance. No correlation was seen between these changes and perfusion time. Among our clinical series there were 2 cases with spontaneous petechiae which, with certainty, were due to bleeding tendency caused by vascular disturbances. 2) Platelet count was markedly reduced during perfusion and return rapidly to normal after neutralization of heparin. This decrease of platelet count was proved to be partly caused not only by mechanical destruction of heart lung machine, but also by heparin itself. Beside vascular disturbances due to peripheral circulatory insufficiency caused by perfusion (atony of peripheral vessels, stagnation of the blood and erythrocyte sludging etc.), heparin was revealed to be a factor of postperfusional vascular damage. For prophylaxis of vascular disturbances due to peripheral circulatory insufficiency, low molecular weight dextran was found effective. Prolongation of bleeding time was considered to be developed because of decreassed capillary resistance. 3) Heparin was proved to have side-effects of decreasing platelet count and capillary resistance, and of increasing capillary permeability. The decrease of platelet count was experimentally found to be reversible and the mechanism of this deficiency was attributed to platelet clump formation by heparin. Decrease of capillary resistance was elicited to be due to dysfunction of the vascular endothelium caused by heparin. Because it was found that heparin had effects to develop petechial hemorrhage, leucocytic sticking to the endothelium and increased extravasation of leucocytes. Prolonged bleeding time and decreased capillary resistance were observed in rabbits in which only platelet count deliberately decreased. Therefore, there must be correlation among them, but it is conceivable that capillary resistance decreased by heparin might be not only due to decrease of platelet count, but also to direct influence on capillary vessels by heparin. en-copyright= kn-copyright= en-aut-name=TsudaHirosumi en-aut-sei=Tsuda en-aut-mei=Hirosumi kn-aut-name=津田弘純 kn-aut-sei=津田 kn-aut-mei=弘純 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第2外科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=8-10 article-no= start-page=1687 end-page=1694 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Tissue Mast Cells in the Liver 2. Observations on the Tissue Mast Cells in the Experimental Damaged Liver kn-title=肝内組織肥満細胞に関する研究 第2編 実験的肝障害時における肝内組織肥満細胞の消長 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the preceding report, the author studied the changes of tissue mast cells (TMC) in the specimens of liver biopsy specimens of viral hepatitis. The present study was attempted to confirm, by animal experiments, the data described in the previous report. Animals used were male dogs, mice and rabbits. Chloroform and carbon tetrachloride were administrated for experimental damage of the liver tissue. The experiments gave the following results: 1. TMC were found both in intralobular and periportal region of the liver. Destructive processes such as dispersion, degranulation, destruction and condensation of the granule in TMC were found in an early stage of the liver damage. A marked increase in number and morphological changes of TMC as the remarkable proliferation of the connective tissue in periportal and intralobular regions were noted in such chronic stage. 2. A marked decrease in number and remarkable morphological changes of TMC were observed in the cases on an adrenocorticosteroid hormon therapy. 3. TMC were chiefly found in the periportal region of rat's liver, and a increase in number and morphological changes were found when the connective tissue increased in the periportal field after long-term administration of hepato-toxic drugs. 4. The asministration of the adrenal cortical hormones induced a marked decrease in number and destractive and condensed chages of TMC granules at this stage. 5. Administrations of the remedies for liver damage such as glucronic acid, thioctic acid, multi-vitamines and communin induced a slight increase in mumber and slight changes in the morphological findings comparing with control groups. The only remarkable change were the condensation of TMC granules. 6. Only a few TMC were found in rabbit's liver, and there were minimal or no changes in TMC, even in the stage of marked damage of the liver tissue. 7. These results lead to the following conculsions: There is a close relation between the proliferation of the connective tissue in dog's and rat's liver and the changes of TMC. en-copyright= kn-copyright= en-aut-name=TogawaAtsushi en-aut-sei=Togawa en-aut-mei=Atsushi kn-aut-name=戸川淳志 kn-aut-sei=戸川 kn-aut-mei=淳志 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=72 cd-vols= no-issue=8-10 article-no= start-page=1695 end-page=1709 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=19601030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Bile Pigment Precursors in Erythrocytes Part 1. Micro-quantitative Analysis of Bile Pigment Precursors in Erythrocytes and its Alteration in Various Experimental Conditions kn-title=赤血球内Bile Pigment Precursorsに関する研究 第1編 赤血球内Bile Pigment Precursorsの微量定量法の検討及び実験的考察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The method of micro-quantitative analysis of bile pigment precursors in erythrocytes was studied and various experimental observations were made for the elucidation of its physiological significance. The following results were obtained: 1. Studies of the fluorescent micro-quantitative analysis made it clear that bile pigment precursors in erythrocytes can be determined in the 0.1-5.0μg/ml biliverdin chloroform solution. Observing its absorption spectrum and fluorescent spectral characteristics, it was also made clear that all the bile pigment precursors were determined by the fluorescence of choleterin zincic complex salt. 2. Gardikas' method of extracting intracorpuscular bile pigment precursors under an anaerobic condition without adding ascorbic acid proved to be better than that of R. Lemberg of extracting by adding ascorbic acid under an aerobic condition. 3. Among normal erythrocytes of various animals were found no significant specific differences, the amount of bile pigment precursors being about 15μg/Hb. 4. When dog's erythrocytes were iucubated at 37℃. after the addition of ascorbic acid, bile pigment precursors in them attained to a remarkably great amount within several hours. This is considered to have resulted from the action of ascorbic acid in choleglobin formation in erythrocytes. 5. 4 hours after phenylhydrazine HCl was administered to a rabbit, the amount of bile pigment precursors in erythrocytes in circulating blood began to increase and attained to its maximum in 4-48 hours. The amount of easily split off blood iron also increased in parallel with it. 6. When canine blood was taken in A.C.D. solution and kept at 4℃., the amount of bile pigment precursors in erythrocytes gradually increased with the course of time, showing a sudden increase after 4 weeks. The amount of easily split off blood iron showed a similar variations. 7. In the erythrocytes of a phlebotomized anemic rabbit, the amount of bile pigment precursors decreased at the same time as reticulocytes showed a remarkable increase. The amount of easily split off blood iron showed a similar tendency of decrease. 8. From the above results the following conclusions were drawn. Bile pigment precursors which are usually observed in normal erythrocytes are increased by chemicals such as ascorbic acid and phenylhydrazine HCl, or by preservation, while in the case of anemia by phlebotomies where immature erythrocytes increase, the amount of bile pigment precursors decreases. Consequently, bile pigment precursors in erythrocytes physiologically increase with deterioration. en-copyright= kn-copyright= en-aut-name=NakagawaShoso en-aut-sei=Nakagawa en-aut-mei=Shoso kn-aut-name=中川昌壮 kn-aut-sei=中川 kn-aut-mei=昌壮 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=11-12 article-no= start-page=1069 end-page=1072 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19631230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Sensitivities for other Antibacterial Agents of Escherichia coli, which Acquired Streptomycin Resistance in Vitro kn-title=試験管内でStreptomycin耐性を獲得した大腸菌の他種抗菌物質に対する感受性に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) Of 18 strains of Escherichia coli, which acquired Streptomycin resistance in vitro, 4 strains acquired Sulfanilamide resistance simultaneously in contamination with Streptomycin. 2) But no Chlorampheuicol nor tetracycline resistant bacteria is observed. 3) 2 strains of the 18 Streptomycin resistaut strains, acquired severe Penicillin sensitivity. On the reasons, authors are researching now. It may be phenomenon of "Collateral Sensitivty (SZYBALSKI)". en-copyright= kn-copyright= en-aut-name=YamagamiAkira en-aut-sei=Yamagami en-aut-mei=Akira kn-aut-name=山上斌 kn-aut-sei=山上 kn-aut-mei=斌 aut-affil-num=1 ORCID= en-aut-name=ArakiNobuko en-aut-sei=Araki en-aut-mei=Nobuko kn-aut-name=荒木暢子 kn-aut-sei=荒木 kn-aut-mei=暢子 aut-affil-num=2 ORCID= en-aut-name=YamamotoMasakazu en-aut-sei=Yamamoto en-aut-mei=Masakazu kn-aut-name=山本雅一 kn-aut-sei=山本 kn-aut-mei=雅一 aut-affil-num=3 ORCID= en-aut-name=TanakaYoshiro en-aut-sei=Tanaka en-aut-mei=Yoshiro kn-aut-name=田中義郎 kn-aut-sei=田中 kn-aut-mei=義郎 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部微生物学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部微生物学教室 END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=1-3 article-no= start-page=283 end-page=295 dt-received= dt-revised= dt-accepted= dt-pub-year=1963 dt-pub=19630330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Leukemoid Reaction in the Mouse Induced by Saponin Part 3. Studies on the vascular structure of the bone marrow kn-title=サポニン投与による実験的類白血病反応に関する研究 第3編 骨髄血管構造所見 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The detailed vascular structure of the bone marrow of saponin-treated mice was studied with clarified bone specimens (Spalteholz's method), because the technic appeared encouraging in elucidating the problems of the mechanism of both granulocytic liberation into the peripheral circulation and development of the extramedullary hematopoiesis. The results obtained were as follows. 1. In the normal control, unit sinuses were connected with each other, and a unit sinus net was primarily composed of 6 unit sinuses in a hexagon form, and many of these sinus nets were mutually connected to make up the complex network. The sinus wall was composed of a single layer of endothelial cells. The vascular system of the bone marrow was a completely closed system, no fenestrated vessel-walls being demonstrable in normal mice. 2. In saponin-treated mice the sinus network was disordered. There was enlargement or narrowing of the sinuses with destruction of their wall. These alterations were seen already at 24 hours after an injection of saponin to mice. At this stage, no extramedullary hematopoiesis was yet seen in spleen tissue culture or in histologic specimens of the spleen. It was considered, therefore, that saponin acted upon sinuses causing destruction of their thin walls. This was followed by the liberation of blood cells into the peripheral cirulation from the destructed sinuses. Finally, these blood cells were transported and multiplied in the organs such as the spleen and liver. The author believe that this is the mechanism of the extramedullary hematopoiesis (colonization theory). The simultaneous finding that megakaryocytes increased in number in the spleen, while their number decreased in the bone marrow gave support to this view. en-copyright= kn-copyright= en-aut-name=SatoTadashi en-aut-sei=Sato en-aut-mei=Tadashi kn-aut-name=佐藤端 kn-aut-sei=佐藤 kn-aut-mei=端 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 END