| Author | Yashiro, Masato| Tsukahara, Hirokazu| Matsukawa, Akihiro| Yamada, Mutsuko| Fujii, Yosuke| Nagaoka, Yoshiharu| Tsuge, Mitsuru| Yamashita, Nobuko| Ito, Toshihiro| Yamada, Masao| Masutani, Hiroshi| |
|---|---|
| Published Date | 2013-01 |
| Publication Title | Critical Care Medicine |
| Volume | volume41 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Nakatsukasa, Yoko| Tsukahara, Hirokazu| Tabuchi, Kazuhisa| Tabuchi, Masako| Magami, Tomoko| Yamada, Mutsuko| Fujii, Yosuke| Yashiro, Masato| Tsuge, Mitsuru| Morishima, Tsuneo| |
|---|---|
| Published Date | 2013-01-01 |
| Publication Title | Journal of Clinical Biochemistry and Nutrition |
| Volume | volume52 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Yashiro, Masato| Tsukahara, Hirokazu| Matsukawa, Akihiro| Yamada, Mutsuko| Fujii, Yosuke| Nagaoka, Yoshiharu| Tsuge, Mitsuru| Yamashita, Nobuko| Ito, Toshihiro| Yamada, Masao| Masutani, Hiroshi| Yodoi, Junji| Morishima, Tsuneo| |
|---|---|
| Published Date | 2013-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/53674 |
|---|---|
| FullText URL | 69_5_279.pdf |
| Author | Saito, Yukie| Fujii, Yousuke| Yashiro, Masato| Tsuge, Mitsuru| Nosaka, Nobuyuki| Yamashita, Nobuko| Yamada, Mutsuko| Tsukahara, Hirokazu| Morishima, Tsuneo| |
| Abstract | Lung hyperpermeability affects the development of acute respiratory distress syndrome (ARDS), but therapeutic strategies for the control of microvascular permeability have not been established. We examined the effects of edaravone, dexamethasone, and N-monomethyl-L-arginine (L-NMMA) on permeability changes in human pulmonary microvascular endothelial cells (PMVEC) under a hypercytokinemic state. Human PMVEC were seeded in a Boyden chamber. After monolayer confluence was achieved, the culture media were replaced respectively by culture media containing edaravone, dexamethasone, and L-NMMA. After 24-h incubation, the monolayer was stimulated with tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Fluorescein-labeled dextran was added. Then the trans-human PMVEC leak was measured. Expressions of vascular endothelial-cadherin (VE-cadherin) and zonula occludens-1 protein (ZO-1) were evaluated using real-time quantitative polymerase chain reaction and immunofluorescence microscopy. The results showed that TNF-α＋IL-1β markedly increased pulmonary microvascular permeability. Pretreatment with edaravone, dexamethasone, or L-NMMA attenuated the hyperpermeability and inhibited the cytokine-induced reduction of VE-cadherin expression on immunofluorescence staining. Edaravone and dexamethasone increased the expression of ZO-1 at both the mRNA and protein levels. Edaravone and dexamethasone inhibited the permeability changes of human PMVEC, at least partly through an enhancement of VE-cadherin. Collectively, these results suggest a potential therapeutic approach for intervention in patients with ARDS. |
| Keywords | pulmonary microvascular endothelial cells permeability edaravone vascular endothelial-cadherin zonula occludens-1 protein |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-10 |
| Volume | volume69 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 279 |
| End Page | 290 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26490025 |
| Web of Science KeyUT | 000365519600004 |
| JaLCDOI | 10.18926/AMO/54987 |
|---|---|
| FullText URL | 71_2_179.pdf |
| Author | Nosaka, Nobuyuki| Tsukahara, Kohei| Knaup, Emily| Yabuuchi, Toshihiko| Kikkawa, Tomonobu| Fujii, Yosuke| Yashiro, Masato| Yasuhara, Takao| Okada, Ayumi| Ugawa, Toyomu| Nakao, Atsunori| Tsukahara, Hirokazu| Date, Isao| |
| Abstract | Newly published clinical practice guidelines recommend intracranial pressure (ICP) monitoring in critical care for the management of pediatric acute encephalopathy (pAE), but the utility of ICP monitoring for pAE has been poorly studied. We recently performed direct ICP monitoring for two patients. We observed that although the direct ICP monitoring had clinical benefits with less body weight gain and no vasopressor use in both cases, this monitoring technique is still invasive. Future studies should determine the utility of non-invasive ICP monitoring systems in pAE to further improve the quality of intensive-care management. |
| Keywords | cerebral perfusion encephalopathy child intracranial pressure neurological intensive care |
| Amo Type | Short Communication |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 179 |
| End Page | 180 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420900 |
| FullText URL | fulltext.pdf fulltext2.pdf |
|---|---|
| Author | Fujii, Yosuke| Yashiro, Masato| Yamada, Mutsuko| Kikkawa, Tomonobu| Nosaka, Nobuyuki| Saito, Yukie| Tsukahara, Kohei| Ikeda, Masanori| Morishima, Tsuneo| Tsukahara, Hirokazu| |
| Published Date | 2018-03-14 |
| Publication Title | Disease Markers |
| Publisher | Hindawi |
| Start Page | 2380179 |
| ISSN | 0278-0240 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2018 Yosuke Fujii et al. |
| File Version | publisher |
| PubMed ID | 29725488 |
| DOI | 10.1155/2018/2380179 |
| Web of Science KeyUT | 000428395400001 |
| Related Url | isVersionOf https://doi.org/10.1155/2018/2380179 |
| JaLCDOI | 10.18926/AMO/57957 |
|---|---|
| FullText URL | 74_1_77.pdf |
| Author | Endo, Hirosuke| Akazawa, Hirofumi| Yashiro, Masato| Yamada, Kazuki| Sanki, Tomoaki| Tetsunaga, Tomonori| Nishida, Keiichiro| Furumatsu, Takayuki| Ozaki, Toshifumi| |
| Abstract | Idiopathic chondrolysis of the hip (ICH), a very rare disorder of unknown etiology, occurs mainly in female adolescents. Characterized by pain, limp, stiffness and radiological narrowing joint space from the rapid destruction of the articular cartilage, ICH sometimes results in ankyloses. We present the case of a 10-year-old girl diagnosed with ICH based on arthroscopic inspection and synovium biopsy. The femoral deformity appeared gradually, like a cam-type femoroacetabular impingement. She was treated with intensive rehabilitation and immunosuppressive drug. We later performed an arthroscopic bumpectomy for residual symptoms. She achieved a favorable outcome as a 15-year-old at the latest follow-up. |
| Keywords | idiopathic chondrolysis hip joint medication bump arthroscopy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 77 |
| End Page | 81 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099253 |
| Web of Science KeyUT | 000516606200012 |
| NAID | 120006795624 |
| FullText URL | JIMHICR_fulltext.pdf |
|---|---|
| Author | Matsuo, Toshihiko| Yashiro, Masato| |
| Keywords | juvenile idiopathic arthritis JIA macular edema uveitis adalimumab steroid responder cataract surgery methotrexate literature review Japanese |
| Published Date | 2020-08-29 |
| Publication Title | Journal of Investigative Medicine High Impact Case Reports |
| Volume | volume8 |
| Publisher | SAGE Publications |
| Start Page | 2324709620953283 |
| ISSN | 2324-7096 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 32862718 |
| DOI | 10.1177/2324709620953283 |
| Web of Science KeyUT | 00566968200001 |
| Related Url | isVersionOf https://doi.org/10.1177/2324709620953283 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Matsuo, Toshihiko| Yashiro, Masato| |
| Keywords | juvenile idiopathic arthritis JIA macular edema uveitis adalimumab steroid responder cataract surgery methotrexate literature review Japanese |
| Published Date | 2020-08-29 |
| Publication Title | Journal of Investigative Medicine High Impact Case Reports |
| Volume | volume8 |
| Publisher | SAGE Publications |
| Start Page | 2324709620953283 |
| ISSN | 2324-7096 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 32862718 |
| DOI | 10.1177/2324709620953283 |
| Web of Science KeyUT | 000566968200001 |
| Related Url | isVersionOf https://doi.org/10.1177/2324709620953283 |
| FullText URL | fulltext20211224-1.pdf |
|---|---|
| Author | Matsuo, Toshihiko| Yashiro, Masato| Yamasaki, Osamu| Tanaka, Takehiro| Manki, Akira| |
| Keywords | autoinflammatory diseases Blau syndrome Muckle-Wells syndrome CINCA/NOMID syndrome cryopyrin-associated periodic syndromes optic disc swelling (optic papillitis) |
| Published Date | 2021-12-19 |
| Publication Title | Life |
| Volume | volume11 |
| Issue | issue12 |
| Publisher | MDPI AG |
| Start Page | 1433 |
| ISSN | 2075-1729 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| DOI | 10.3390/life11121433 |
| Related Url | isVersionOf https://doi.org/10.3390/life11121433 |
| FullText URL | fulltext20210908-1.pdf figure20210908-1.pdf |
|---|---|
| Author | Namba, Takahiro| Tsuge, Mitsuru| Yashiro, Masato| Saito, Yukie| Liu, Keyue| Nishibori, Masahiro| Morishima, Tsuneo| Tsukahara, Hirokazu| |
| Keywords | Influenza Acute respiratory distress syndrome High mobility group box 1 Human pulmonary microvascular endothelial cell Cytokine Tumor necrosis factor-α |
| Note | This is an Accepted Manuscript of an article published by Springer Science. This fulltext is available in Aug. 2022.| |
| Published Date | 2021-8-29 |
| Publication Title | Inflammation Research |
| Publisher | Springer Science and Business Media LLC |
| ISSN | 1023-3830 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 34455489 |
| DOI | 10.1007/s00011-021-01496-5 |
| Web of Science KeyUT | 000690802000001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00011-021-01496-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miyahara, Hiroyuki| Hasegawa, Kosei| Yashiro, Masato| Ohara, Toshiaki| Fujisawa, Masayoshi| Yoshimura, Teizo| Matsukawa, Akihiro| Tsukahara, Hirokazu| |
| Published Date | 2022-03-21 |
| Publication Title | Scientific Reports |
| Volume | volume12 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 4819 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022 |
| File Version | publisher |
| PubMed ID | 35314758 |
| DOI | 10.1038/s41598-022-08791-z |
| Web of Science KeyUT | 000771589000002 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-022-08791-z |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uda, Kazuhiro| Hagiya, Hideharu| Yorifuji, Takashi| Koyama, Toshihiro| Tsuge, Mitsuru| Yashiro, Masato| Tsukahara, Hirokazu| |
| Keywords | RSV Surveillance Google Trends Epidemiology |
| Published Date | 2022-08-09 |
| Publication Title | BMC Public Health |
| Volume | volume22 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 1517 |
| ISSN | 1471-2458 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2022. |
| File Version | publisher |
| PubMed ID | 35945532 |
| DOI | 10.1186/s12889-022-13899-y |
| Web of Science KeyUT | 000838077700004 |
| Related Url | isVersionOf https://doi.org/10.1186/s12889-022-13899-y |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Namba, Takahiro| Takeuchi, Akihito| Matsumoto, Naomi| Tsuge, Mitsuru| Yashiro, Masato| Tsukahara, Hirokazu| Yorifuji, Takashi| |
| Keywords | Kawasaki disease (KD) birth order group childcare infectious diseases vasculitis |
| Published Date | 2023-03-28 |
| Publication Title | Frontiers in Pediatrics |
| Volume | volume11 |
| Publisher | Frontiers Media |
| Start Page | 1127053 |
| ISSN | 2296-2360 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Namba, Takeuchi, Matsumoto, Tsuge, Yashiro, Tsukahara and Yorifuji. |
| File Version | publisher |
| PubMed ID | 37056943 |
| DOI | 10.3389/fped.2023.1127053 |
| Web of Science KeyUT | 000965495400001 |
| Related Url | isVersionOf https://doi.org/10.3389/fped.2023.1127053 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tsuge, Mitsuru| Shigehara, Kenji| Uda, Kazuhiro| Kawano, Seiji| Iwamuro, Masaya| Saito, Yukie| Yashiro, Masato| Ikeda, Masanori| Tsukahara, Hirokazu| |
| Keywords | Duodenal ulcer Dupilumab Eosinophilic gastroenteritis Eotaxin-3 Food allergy Interleukin-5 Interleukin-13 Non-esophageal eosinophilic gastrointestinal disorder |
| Note | The version of record of this article, first published in Allergy, Asthma & Clinical Immunology, is available online at Publisher’s website: http://dx.doi.org/10.1186/s13223-023-00859-3| |
| Published Date | 2023-12-05 |
| Publication Title | Allergy, Asthma & Clinical Immunology |
| Volume | volume19 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 103 |
| ISSN | 1710-1492 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023. |
| File Version | publisher |
| PubMed ID | 38053199 |
| DOI | 10.1186/s13223-023-00859-3 |
| Web of Science KeyUT | 001113362100001 |
| Related Url | isVersionOf https://doi.org/10.1186/s13223-023-00859-3 |
