JaLCDOI 10.18926/AMO/53120
FullText URL 69_1_37.pdf
Author Iwamuro, Masaya| Okada, Hiroyuki| Takata, Katsuyoshi| Kawai, Yoshinari| Kawano, Seiji| Nasu, Junichiro| Kawahara, Yoshiro| Tanaka, Takehiro| Yoshino, Tadashi| Yamamoto, Kazuhide|
Abstract The sensitivity and specificity of magnified endoscopic features for differentiating follicular lymphoma from other diseases with duodenal whitish lesions have never been investigated. Here we compared the magnified endoscopic features of duodenal follicular lymphoma with those of other whitish lesions. We retrospectively reviewed the cases of patients with follicular lymphoma (n=9), lymphangiectasia (n=7), adenoma (n=10), duodenitis (n=4), erosion (n=1), lymphangioma (n=1), and hyperplastic polyp (n=1). The magnified features of the nine follicular lymphomas included enlarged villi (n=8), dilated microvessels (n=5), and opaque white spots of various sizes (n=9). The lymphangiectasias showed enlarged villi, dilated microvessels, and white spots, but the sizes of the white spots were relatively homogeneous and their margin was clear. Observation of the adenoma and duodenitis revealed only whitish villi. Although the lymphangioma was indistinguishable from the follicular lymphomas by magnified features, it was easily diagnosed based on the macroscopic morphology. In conclusion, magnified endoscopic features, in combination with macroscopic features, are useful for differentiating follicular lymphomas from other duodenal diseases presenting whitish lesions.
Keywords duodenal neoplasm follicular lymphoma gastrointestinal lymphoma magnifying endoscopy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-02
Volume volume69
Issue issue1
Publisher Okayama University Medical School
Start Page 37
End Page 44
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25703169
Web of Science KeyUT 000349740300004
JaLCDOI 10.18926/AMO/53676
FullText URL 69_5_301.pdf
Author Seki, Anna| Iwamuro, Masaya| Yoshioka, Masao| Fujii, Nobuharu| Okada, Hiroyuki| Nose, Soichiro| Takata, Katsuyoshi| Yoshino, Tadashi| Yamamoto, Kazuhide|
Abstract A 41-year-old woman was diagnosed with duodenal follicular lymphoma. She had no other lesions and was assigned to a "watch and wait" policy. Swelling of the inguinal lymph nodes appeared 45 months later, and rituximab monotherapy resulted in complete remission. However, follicular lymphoma recurred in the stomach, rectum and mesenteric and external iliac lymph nodes 81 months after the therapy. The patient received rituximab monotherapy again and has remained in complete remission in the fifteenth year after the initial diagnosis. This case suggests the usefulness of rituximab monotherapy in the long-term management of intestinal follicular lymphoma.
Keywords follicular lymphoma duodenum rituximab
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2015-10
Volume volume69
Issue issue5
Publisher Okayama University Medical School
Start Page 301
End Page 306
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26490027
Web of Science KeyUT 000365519600006
JaLCDOI 10.18926/AMO/54815
FullText URL 70_6_503.pdf
Author Kanazawa, Yui| Yamashita, Yuka| Fujiwara, Mitsuhiro| Muraoka, Michiko| Washio, Kana| Kanamitsu, Kiichiro| Ishida, Hisashi| Nakano, Takae| Yamada, Miho| Horibe, Keizo| Tanaka, Takehiro| Yoshino, Tadashi| Shimada, Akira|
Abstract Childhood anaplastic large cell lymphoma (ALCL) accounts for approx. 10–30 of cases of non-Hodgkin lymphoma, and the ALCL99 study reported 60–75 disease-free survival; however, a relatively high relapse rate was observed (25–30 ). We report 2 patients with Stage III ALCL who relapsed 6–18 months after the end of ALCL99 chemotherapy. A retrospective molecular analysis identified the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) fusion gene in the first diagnostic bone marrow samples taken from both patients. However, antibodies against the ALK protein appeared to be relatively low in the serum of both patients (×100 and ×750). An increase in chemotherapy intensity may be beneficial if Stage III ALCL patients are shown to be NPM-ALK chimera-positive in the first diagnostic bone marrow sample.
Keywords ALCL NPM-ALK fusion lymphoma
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2016-12
Volume volume70
Issue issue6
Publisher Okayama University Medical School
Start Page 503
End Page 506
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28003677
JaLCDOI 10.18926/AMO/54978
FullText URL 71_2_105.pdf
Author Shinya, Takayoshi| Tanaka, Takashi| Soh, Junichi| Matsushita, Toshi| Sato, Shuhei| Toyooka, Shinichi| Yoshino, Tadashi| Miyoshi, Shinichiro| Kanazawa, Susumu|
Abstract We retrospectively assessed the dual-time-point (DTP) F-18 FDG PET/CT findings of thymic epithelial neoplasms (TENs) and investigated the diagnostic capacity of PET/CT compared to that of CT for predicting carcinoma. We calculated the ratio of the standardized uptake value of the tumor and that of the aortic arch (T/M ratio) for both the 90-min early scan and the 2-h delayed scan in 56 TEN patients. We used a multivariate logistic regression (MLR) analysis to estimate the CT features of carcinoma. We compared the diagnostic capacities of PET/CT and chest CT using receiver operating characteristic (ROC) analyses. The ROC curve revealed that the appropriate cut-off T/M ratio value for the highest accuracy was 2.39 with 75.0% accuracy. The area under the curve (AUC) was 0.855. The statistical analyses for DTP scans of 35 TEN patients demonstrated 74.3% accuracy and 0.838 AUC for the early scan versus 82.9% and 0.825 for the delayed scan. The MLR analysis indicated that mediastinal fat infiltration was a predictor of carcinoma. The ROC curve obtained for the model yielded an AUC of 0.853. Delayed scanning could improve the diagnostic capacity for carcinoma. The T/M ratio and mediastinal fat infiltration are predictive of carcinoma with moderate diagnostic accuracy.
Keywords thymic epithelial neoplasm thymic carcinoma thymoma dual-time-point PET/CT chest CT
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2017-04
Volume volume71
Issue issue2
Publisher Okayama University Medical School
Start Page 105
End Page 112
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28420891
Author Gotoda, Tatsuhiro| Kawano, Seiji| Kono, Yoshiyasu| Miura, Kou| Kanzaki, Hiromitsu| Iwamuro, Masaya| Kawahara, Yoshiro| Tanaka, Takehiro| Yoshino, Tadashi| Shirakawad, Yasuhiro| Tabata, Masahiro| Tanimoto, Mitsune| Okada, Hiroyuki|
Published Date 2016-12-01
Publication Title Journal of Okayama Medical Association
Volume volume128
Issue issue3
Content Type Journal Article
JaLCDOI 10.18926/AMO/30484
FullText URL fulltext.pdf
Author Tonoyama, Yuji| Teramoto, Norihiro| Sarker, Ashit Baran| Yoshino, Tadashi| Hayashi, Kazuhiko| Takahashi, Kiyoshi| Akagi, Tadaatsu|
Abstract

To elucidate the latent state and reactivation of Epstein-Barr virus (EBV) in non-neoplastic lymphoid lesions, we investigated 144 non-neoplastic lymphoid lesions by in situ hybridization (ISH) to detect the expression of EBV-encoded small RNAs (EBER)-1 and BCRF-1 and by immunostaining for latent membrane protein (LMP)-1 and ZEBRA. ISH for EBER-1 detected EBER-1-positive cells (EPC) in 31 of the 144 examined lesions (22%). EPC were detected in 4 of 49 cases of nonspecific lymphoid hyperplasia, in 16 of 20 abscess-forming granulomatous lymphadenitis (AFGL), 5 of 25 Kikuchi's disease, and in 3 of 3 infectious mononucleosis. LMP-1 was expressed in 6 of 124 non-neoplastic lymphoid lesions (4.8%). LMP-1-positive cells were observed in 6 of the 31 EBER-1-positive cases (19%). EPC were detected significantly more frequently in LMP-1- and ZEBRA-positive specimens than in the LMP-1- and ZEBRA-negative specimens. BCRF-1 was expressed in 4 of 11 cases examined: 2 of 3 AFGL, 1 of 2 Kikuchi's disease, and in the 1 case of atypical lymphoid hyperplasia. This study suggests that Epstein-Barr virus is prevalent and can be reactivated in the lymph nodes effaced by destructive inflammation, such as AFGL. Such inflammation may provide a local milieu that is conducive for EBV to enter the lytic cycle.

Keywords EBER-I BCRF-l LMP-l ZEBRA lymphoid lesion
Amo Type Article
Publication Title Acta Medica Okayama
Published Date 1996-04
Volume volume50
Issue issue2
Publisher Okayama University Medical School
Start Page 89
End Page 96
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 8744934
Web of Science KeyUT A1996UJ08100005
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/5331
Author Sato, Yasuharu| Yoshino, Tadashi|
Published Date 2010-04-01
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue1
Content Type Journal Article
FullText URL K0005304 other1.pdf
Author Igawa, Takuro| Sato, Yasuharu| Takata, Katsuyoshi| Iwaki, Noriko| Tanaka, Takehiro| Asano, Naoko| Maeda, Yoshinobu| Orita, Yorihisa| Nakamura, Naoya| Nakamura, Shigeo| Yoshino, Tadashi|
Keywords Cyclin D2 CD5 Diffuse large B-cell lymphoma
Note 学位審査副論文|
Published Date 2013-05-15
Publication Title Diagnostic Pathology
Volume volume8
Publisher BioMed Central
Start Page 81
ISSN 1746-1596
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version publisher
PubMed ID 23675804
DOI 10.1186/1746-1596-8-81
Web of Science KeyUT 000319266300002
Related Url https://doi.org/10.1186/1746-1596-8-81 http://ousar.lib.okayama-u.ac.jp/54287
FullText URL blood_119_1_285.pdf
Author Nishimori, Hisakazu| Maeda, Yoshinobu| Teshima, Takanori| Sugiyama, Haruko| Kobayashi, Koichiro| Yamasuji, Yoshiko| Kadohisa, Sachiyo| Uryu, Hidetaka| Takeuchi, Kengo| Tanaka, Takehiro| Yoshino, Tadashi| Iwakura, Yoichiro| Tanimoto, Mitsune|
Note This research was originally published in Blood. 2012. © the American Society of Hematology.|
Published Date 2012-01-05
Publication Title Blood
Volume volume119
Issue issue1
Start Page 285
End Page 295
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version publisher
PubMed ID 22077062
DOI 10.1182/blood-2011-01-332478
Web of Science KeyUT 000299012400035
Related Url https://doi.org/10.1182/blood-2011-01-332478
JaLCDOI 10.18926/AMO/64363
FullText URL 77_1_65.pdf
Author Sato, Ken| Takigawa, Nagio| Kubo, Toshio| Katayama, Hideki| Kishino, Daizo| Okada, Toshiaki| Hisamoto, Akiko| Mimoto, Junko| Ochi, Nobuaki| Yoshino, Tadashi| Ueoka, Hiroshi| Tanimoto, Mitsune| Maeda, Yoshionobu| Kiura, Katsuyuki|
Abstract We investigated the effects of celecoxib combined with (−)-epigallocatechin-3-gallate (EGCG) or polyphenon E in a cisplatin-induced lung tumorigenesis model. Four-week-old female A/J mice were divided into seven groups: (i) Control, (ii) 150 mg/kg celecoxib (150Cel), (iii) 1,500 mg/kg celecoxib (1500Cel), (iv) EGCG+150 mg/kg celecoxib (EGCG+150Cel), (v) EGCG+1,500 mg/kg celecoxib (EGCG+1500Cel), (vi) polyphenon E+150 mg/kg celecoxib (PolyE+150Cel), and (vii) polyphenon E+1,500 mg/kg celecoxib (PolyE+1500Cel). All mice were administered cisplatin (1.62 mg/kg of body weight, i.p.) 1×/week for 10 weeks and sacrificed at week 30; the numbers of tumors on the lung surface were then determined. The tumor incidence and multiplicity (no. of tumors/mouse, mean±SD) were respectively 95% and 2.15±1.50 in Control, 95% and 2.10±1.29 in 150Cel, 86% and 1.67±1.20 in 1500Cel, 71% and 1.38±1.24 in EGCG+150Cel, 67% and 1.29±1.38 in EGCG+1500Cel, 80% and 1.95±1.36 in PolyE+150Cel, and 65% and 1.05±0.10 in PolyE+1500Cel. The combination of high-dose celecoxib with EGCG or polyphenon E significantly reduced multiplicity in cisplatin-induced lung tumors.
Keywords celecoxib cisplatin EGCG lung tumor polyphenon E
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-02
Volume volume77
Issue issue1
Publisher Okayama University Medical School
Start Page 65
End Page 70
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36849147
Web of Science KeyUT 000952992100004
FullText URL ANL_46_6_927.pdf Fig_table.pdf
Author Makihara, Seiichiro| Kariya, Shin| Noujima-Harada, Mai| Ohara, Nobuya| Naito, Tomoyuki| Matsumoto, Junya| Noda, Yohei| Okano, Mitsuhiro| Yoshino, Tadashi| Nishizaki, Kazunori|
Keywords MTX-associated LPD Methotrexate Pulmonary nodules
Note This fulltext will be available in Aug 2020|
Published Date 2019-12-31
Publication Title Auris Nasus Larynx
Volume volume46
Issue issue6
Publisher Elsevier
Start Page 927
End Page 933
ISSN 03858146
NCID AA00061157
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 Elsevier B.V. All rights reserved.
File Version author
PubMed ID 30739816
DOI 10.1016/j.anl.2019.01.010
Web of Science KeyUT 000488997100018
Related Url isVersionOf https://doi.org/10.1016/j.anl.2019.01.010
FullText URL ecancermedicalscience2019_933.pdf
Author Iwamuro, Masaya| Tanaka, Takehiro| Nishida, Kenji| Kanzaki, Hiromitsu| Kawano, Seiji| Kawahara, Yoshiro| Yoshino, Tadashi| Okada, Hiroyuki|
Keywords follicular gastritis gastric neoplasms gastrointestinal endoscope mucosa-associated lymphoid tissue lymphoma nodular gastritis
Published Date 2019-06-03
Publication Title ecancermedicalscience
Volume volume13
Publisher CANCER INTELLIGENCE
Start Page 933
ISSN 1754-6605
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © the authors
File Version publisher
PubMed ID 31281430
DOI 10.3332/ecancer.2019.933
Web of Science KeyUT 000472729000001
Related Url isVersionOf https://doi.org/10.3332/ecancer.2019.933
FullText URL NCN7_3_146.pdf Fig.pdf
Author Matsumoto, Namiko| Sato, Kota| Takahashi, Yoshiaki| Kawahara, Yuko| Yunoki, Taijun| Shang, Jingwei| Takemoto, Mami| Hishikawa, Nozomi| Ohta, Yasuyuki| Yamashita, Toru| Sakamoto, Maiko| Kondou, Eisei| Shibata, Rei| Yoshino, Tadashi| Ozaki, Toshifumi| Abe, Koji|
Keywords neurolymphomatosis neuro-oncology peripheral neuropathy peripheral nerve rheumatoid arthritis T-cell lymphoma
Note This fulltext will be available in Feb 2020|
Published Date 2019-02-19
Publication Title Neurology and Clinical Neuroscience
Volume volume7
Issue issue3
Publisher Wiley
Start Page 146
End Page 149
ISSN 2049-4173
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
DOI 10.1111/ncn3.12280
Web of Science KeyUT 000466785700011
Related Url isVersionOf https://doi.org/10.1111/ncn3.12280
FullText URL SR9_1_761.pdf
Author Gion, Yuka| Takeuchi, Mai| Shibata, Rei| Takata, Katsuyoshi| Miyata-Takata, Tomoko| Orita, Yorihisa| Tachibana, Tomoyasu| Yoshino, Tadashi| Sato, Yasuharu|
Published Date 2019-1-24
Publication Title Scientific Reports
Volume volume9
Publisher Nature Publishing Group
Start Page 761
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2019
File Version publisher
PubMed ID 30679751
DOI 10.1038/s41598-018-37404-x
Web of Science KeyUT 000456554600200
Related Url isVersionOf https://doi.org/10.1038/s41598-018-37404-x
FullText URL JCEH59_2_64.pdf
Author Ikeda, Tomoka| Gion, Yuka| Yoshino, Tadashi| Sato, Yasuharu|
Keywords EBV-positive mucocutaneous ulcer clinical features immunosuppression pathological features
Published Date 2019-06-28
Publication Title Journal of Clinical and Experimental Hematopathology
Volume volume59
Issue issue2
Publisher Japanese Society for Lymphoratic Tissue Research
Start Page 64
End Page 6471
ISSN 1346-4280
NCID AA11556796
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders Copyright © 2019 The Japanese Society for Lymphoreticular Tissue Research
File Version publisher
PubMed ID 31257347
DOI 10.3960/jslrt.18039
Web of Science KeyUT 000473169400004
Related Url isVersionOf https://doi.org/10.3960/jslrt.18039
FullText URL fulltext.pdf
Author Makimoto, Go| Ohashi, Kadoaki| Taniguchi, Kohei| Soh, Junichi| Taniguchi, Akihiko| Miyahara, Nobuaki| Toyooka, Shinichi| Yoshino, Tadashi| Maeda, Yoshinobu| Kiura, Katsuyuki|
Keywords IgG4-related disease Pleural effusion Adenosine deaminase Pleural biopsy Spontaneous remission
Published Date 2019
Publication Title Respiratory Medicine Case Reports
Volume volume28
Publisher Elsevier
Start Page 100938
ISSN 2213-0071
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors.
File Version publisher
PubMed ID 31667074
DOI 10.1016/j.rmcr.2019.100938
Web of Science KeyUT 000511444900052
Related Url isVersionOf https://doi.org/10.1016/j.rmcr.2019.100938
FullText URL fulltext.pdf
Author Ikeda, Tomoka| Gion, Yuka| Sakamoto, Misa| Tachibana, Tomoyasu| Nishikori, Asami| Nishimura, Midori Filiz| Yoshino, Tadashi| Sato, Yasuharu|
Keywords Lymphoid tissues Lymphoma
Published Date 2020-06-19
Publication Title Modern Pathology
Volume volume33
Issue issue12
Publisher Springer Nature
Start Page 2437
End Page 2448
ISSN 0893-3952
NCID AA1067307X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Authors
File Version author
PubMed ID 32561847
DOI 10.1038/s41379-020-0599-8
Web of Science KeyUT 000541317200003
Related Url isVersionOf https://doi.org/10.1038/s41379-020-0599-8
Author Okuma, Yu| Liu, Keyue| Wake, Hidenori| Haruma, Jun| Yoshino, Tadashi| Ohtsuka, Aiji| Takahashi, Hideo| Mori, Shuji| Nishibori, Masahiro| Date, Isao|
Published Date 2013-08-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue2
Content Type Journal Article
Author Takata, Katsuyoshi| Sato, Yasuharu| Nakamura, Naoya| Tokunaka, Mami| Miki, Yukari| Kikuti, Yara Yukie| Igarashi, Kazuhiko| Ito, Etsuro| Harigae, Hideo| Kato, Seiichi| Hayashi, Eiko| Oka, Takashi| Hoshii, Yoshinobu| Tari, Akira| Okada, Hiroyuki| Mohamado, ABD Alkader Lamia| Maeda, Yoshinobu| Tanimoto, Mitsune| Kinoshita, Tomohiro| Yoshino, Tadashi|
Published Date 2013-08-01
Publication Title 岡山医学会雑誌
Volume volume125
Issue issue2
Content Type Journal Article
JaLCDOI 10.18926/AMO/51072
FullText URL 67_4_265.pdf
Author Hanakawa, Hiroyuki| Orita, Yorihisa| Sato, Yasuharu| Uno, Kinya| Nishizaki, Kazunori| Yoshino, Tadashi|
Abstract We present a case of a 67-year-old Japanese man with a serious oropharyngeal ulceration that at first seemed to be destructive malignant lymphoma or oropharyngeal carcinoma. We suspected methotrexate (MTX)-associated lymphoproliferative disorder (LPD) induced by MTX treatment for rheumatoid arthritis (RA). About 3 weeks after simple discontinuation of MTX, complete regression of the disease was observed, confirming our diagnosis.
Keywords ulceration methotrexate oropharynx lymphoproliferative disorders
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2013-08
Volume volume67
Issue issue4
Publisher Okayama University Medical School
Start Page 265
End Page 269
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23970326
Web of Science KeyUT 000323470100009