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ID 53648
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Kyotaro, Ohno
Yasuharu, Sato
Koh-ichi, Ohshima
Katsuyoshi, Takata
Tomoko, Miyata-Takata
Mai, Takeuchi
Yuka, Gion
Tomoyasu, Tachibana
Yorihisa, Orita
Toshihiro, Ito
Steven, H. Swerdlow
Tadashi, Yoshino Kakenhi
Abstract
We previously suggested a relationship between ocular immunoglobulin (Ig)G4-related disease (IgG4-RD) and marginal zone lymphomas (MZLs). However, the cytokine background associated with these disorders and whether it differs between ocular adnexal MZLs with (IgG4-associated MZL) and without (IgG4-negative MZL) numerous IgG4+ plasma cells are unknown. In this study, we identified the mRNA expression pattern of Th2 and regulatory T-cell (Treg) cytokines in IgG4-RD and in IgG4-associated MZL and IgG4-negative MZL using real-time polymerase chain reaction analysis. Ocular IgG4-RD and IgG4-associated MZL exhibited significantly higher expression ratios of interleukin (IL)-4/β-actin, IL-10/β-actin, IL-13/β-actin, transforming growth factor (TGF) β1/β-actin, and FOXP3/β-actin than did IgG4-negative MZL (p < 0.05). This finding further supports our prior observations that a significant subset of ocular MZLs arises in the setting of IgG4-RD. Furthermore, the presence of a different inflammatory background in IgG4-negative MZLs suggests that IgG4-associated MZLs may have a different pathogenesis.
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Published Date
2015
Publication Title
Scientific Reports
Volume
volume5
Publisher
Nature Publishing Group
Start Page
13539
ISSN
2045-2322
Content Type
Journal Article
Official Url
http://dx.doi.org/10.1038/srep13539
language
英語
Copyright Holders
© 2015 Nature Publishing Group
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Refereed
True
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