Author | Wake, Hidenori| |
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Published Date | 2009-08-03 |
Publication Title | 岡山医学会雑誌 |
Volume | volume121 |
Issue | issue2 |
Content Type | Journal Article |
Author | Liu, Keyue| Mori, Shuji| Takahashi, Hideo| Tomono, Yasuko| Wake, Hidenori| Kanke, Toru| Sato, Yasuharu| Hiraga, Norihito| Adachi, Naoto| Yoshino, Tadashi| Nishibori, Masahiro| |
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Published Date | 2008-12-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume120 |
Issue | issue3 |
Content Type | Journal Article |
FullText URL | fulltext.pdf |
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Author | Hatipoglu, Omer Faruk| Uctepe, Eyyup| Opoku, Gabriel| Wake, Hidenori| Ikemura, Kentaro| Ohtsuki, Takashi| Inagaki, Junko| Gunduz, Mehmet| Gunduz, Esra| Watanabe, Shogo| Nishinaka, Takashi| Takahashi, Hideo| Hirohata, Satoshi| |
Keywords | Pulmonary fibrosis Osteopontin Epithelial-mesenchymal transition |
Published Date | 2021-07 |
Publication Title | Biomedicine & Pharmacotherapy |
Volume | volume139 |
Publisher | Elsevier France-Editions Scientifiques Medicales e |
Start Page | 111633 |
ISSN | 0753-3322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 The Author(s). |
File Version | publisher |
DOI | 10.1016/j.biopha.2021.111633 |
Web of Science KeyUT | 000663683300007 |
Related Url | isVersionOf https://doi.org/10.1016/j.biopha.2021.111633 |
FullText URL | fulltext.pdf |
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Author | Kuroda, Kosuke| Ishii, Kenzo| Mihara, Yuko| Kawanoue, Naoya| Wake, Hidenori| Mori, Shuji| Yoshida, Michihiro| Nishibori, Masahiro| Morimatsu, Hiroshi| |
Published Date | 2021-05-13 |
Publication Title | Scientific Reports |
Volume | volume11 |
Issue | issue1 |
Publisher | Nature Research |
Start Page | 10223 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2021 |
File Version | publisher |
PubMed ID | 33986340 |
NAID | 120007053368 |
DOI | 10.1038/s41598-021-89555-z |
Web of Science KeyUT | 000656946100013 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-021-89555-z |
JaLCDOI | 10.18926/AMO/57366 |
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FullText URL | 73_5_379.pdf |
Author | Wake, Hidenori| |
Abstract | Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding and functional properties of HRG in sepsis. |
Keywords | htidine-rich glycoprotein septic pathogenesis immunothrombosis |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2019-10 |
Volume | volume73 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 379 |
End Page | 382 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 31649362 |
Web of Science KeyUT | 000491886600001 |
FullText URL | fulltext.pdf |
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Author | Tomonobu, Nahoko| Kinoshita, Rie| Wake, Hidenori| Inoue, Yusuke| Ruma, I. Made Winarsa| Suzawa, Ken| Gohara, Yuma| Komalasari, Ni Luh Gede Yoni| Jiang, Fan| Murata, Hitoshi| Yamamoto, Ken-Ichi| Sumardika, I. Wayan| Chen, Youyi| Futami, Junichiro| Yamauchi, Akira| Kuribayashi, Futoshi| Kondo, Eisaku| Toyooka, Shinichi| Nishibori, Masahiro| Sakaguchi, Masakiyo| |
Keywords | S100A8/A9 HRG metastasis |
Published Date | 2022-09-07 |
Publication Title | International Journal Of Molecular Sciences |
Volume | volume23 |
Issue | issue18 |
Publisher | MDPI |
Start Page | 10300 |
ISSN | 1422-0067 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 by the authors. |
File Version | publisher |
PubMed ID | 36142212 |
DOI | 10.3390/ijms231810300 |
Web of Science KeyUT | 000858719600001 |
Related Url | isVersionOf https://doi.org/10.3390/ijms231810300 |
FullText URL | fulltext.pdf |
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Author | Gao, Shangze| Wake, Hidenori| Sakaguchi, Masakiyo| Wang, Dengli| Takahashi, Youhei| Teshigawara, Kiyoshi| Zhong, Hui| Mori, Shuji| Liu, Keyue| Takahashi, Hideo| Nishibori, Masahiro| |
Published Date | 2020-06-26 |
Publication Title | iScience |
Volume | volume23 |
Issue | issue6 |
Publisher | Cell Press |
Start Page | 101180 |
ISSN | 2589-0042 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 The Authors. |
File Version | publisher |
PubMed ID | 32498020 |
DOI | 10.1016/j.isci.2020.101180 |
Web of Science KeyUT | 000548236600006 |
Related Url | isVersionOf https://doi.org/10.1016/j.isci.2020.101180 |
FullText URL | fulltext.pdf |
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Author | Gao, Shangze| Liu, Keyue| Ku, Wenhan| Wang, Dengli| Wake, Hidenori| Qiao, Handong| Teshigawara, Kiyoshi| Nishibori, Masahiro| |
Keywords | Histamine HMGB1 vascular endothelial cell H-1 receptor hypotension |
Published Date | 2022-10-05 |
Publication Title | Frontiers In Immunology |
Volume | volume13 |
Publisher | Frontiers Media SA. |
Start Page | 930683 |
ISSN | 1664-3224 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 Gao, Liu, Ku, Wang, Wake, Qiao, Teshigawara and Nishibori. |
File Version | publisher |
PubMed ID | 36275732 |
DOI | 10.3389/fimmu.2022.930683 |
Web of Science KeyUT | 000873745300001 |
Related Url | isVersionOf https://doi.org/10.3389/fimmu.2022.930683 |
JaLCDOI | 10.18926/AMO/31845 |
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FullText URL | fulltext.pdf |
Author | Wake, Hidenori| Mori, Shuji| Liu, Keyue| Takahashi, Hideo K.| Nishibori, Masahiro| |
Abstract | Angiogenesis involves complex processes mediated by several factors and is associated with inflammation and wound healing. High mobility group box 1 (HMGB1) is released from necrotic cells as well as macrophages and plays proinflammatory roles. In the present study, we examined whether HMGB1 would exhibit angiogenic activity in a matrigel plug assay in mice. HMGB1 in combination with heparin strongly induced angiogenesis, whereas neither HMGB1 nor heparin alone showed such angiogenic activity. The heparin-dependent induction of angiogenesis by HMGB1 was accompanied by increases in the expression of tumor necrosis factor-alpha (TNF-alpha) and vascular endothelial growth factor-A120 (VEGF-A120). It is likely that the dependence of the angiogenic activity of HMGB1 on heparin was due to the efficiency of the diffusion of the HMGB1-heparin complex from matrigel to the surrounding areas. VEGF-A165 possessing a heparin-binding domain showed a pattern of heparin-dependent angiogenic activity similar to that of HMGB1. The presence of heparin also inhibited the degradation of HMGB1 by plasmin in vitro. Taken together, these results suggested that HMGB1 in complex with heparin possesses remarkable angiogenic activity, probably through the induction of TNF-alpha and VEGF-A120. |
Keywords | angiogenesis HMGB1 heparin |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2009-10 |
Volume | volume63 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 249 |
End Page | 262 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 19893601 |
Web of Science KeyUT | 000271132000005 |
FullText URL | fulltext.pdf |
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Author | Nishibori, Masahiro| Wang, Dengli| Ousaka, Daiki| Wake, Hidenori| |
Keywords | high mobility group box-1 blood-brain barrier inflammation stroke trauma vascular endothelial cell pericyte monoclonal antibody |
Published Date | 2020-12-10 |
Publication Title | Cells |
Volume | volume9 |
Issue | issue12 |
Publisher | MDPI |
Start Page | 2650 |
ISSN | 2073-4409 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 33321691 |
DOI | 10.3390/cells9122650 |
Web of Science KeyUT | 000601700200001 |
Related Url | isVersionOf https://doi.org/10.3390/cells9122650 |
FullText URL | fulltext.pdf |
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Author | Yamashiro, Keisuke| Ideguchi, Hidetaka| Aoyagi, Hiroaki| Yoshihara-Hirata, Chiaki| Hirai, Anna| Suzuki-Kyoshima, Risa| Zhang, Yao| Wake, Hidenori| Nishibori, Masahiro| Yamamoto, Tadashi| Takashiba, Shogo| |
Keywords | high mobility group box 1 inflammation periodontal regeneration periodontitis osseointegration tooth movement wound healing |
Published Date | 2020-07-14 |
Publication Title | Frontiers in Immunology |
Volume | volume11 |
Publisher | Frontiers Media |
Start Page | 1461 |
ISSN | 1664-3224 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 Yamashiro et al. |
File Version | publisher |
PubMed ID | 32760399 |
DOI | 10.3389/fimmu.2020.01461 |
Web of Science KeyUT | 000556581900001 |
Related Url | isVersionOf https://doi.org/10.3389/fimmu.2020.01461 |
Author | Wake, Hidenori| |
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Published Date | 2009-09-30 |
Publication Title | |
Content Type | Thesis or Dissertation |
FullText URL | fulltext.pdf |
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Author | Wang, Dengli| Liu, Keyue| Fukuyasu, Yusuke| Teshigawara, Kiyoshi| Fu, Li| Wake, Hidenori| Ohtsuka, Aiji| Nishibori, Masahiro| |
Keywords | middle cerebral artery occlusion high-mobility group box 1 subcellular localization and subcellular organelle |
Published Date | 2020-03-06 |
Publication Title | Cells |
Volume | volume9 |
Issue | issue3 |
Publisher | MDPI |
Start Page | 643 |
ISSN | 2073-4409 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 32155899 |
DOI | 10.3390/cells9030643 |
Web of Science KeyUT | 000529337400120 |
Related Url | isVersionOf https://doi.org/10.3390/cells9030643 |
JaLCDOI | 10.18926/AMO/31812 |
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FullText URL | fulltext.pdf |
Author | Liu, Rui| Mori, Shuji| Wake, Hidenori| Zhang, Jiyong| Liu, Keyue| Izushi, Yasuhisa| Takahashi, Hideo K.| Peng, Bo| Nishibori, Masahiro| |
Abstract | Interaction between the receptor for advanced glycation end products (RAGE) and its ligands has been implicated in the pathogenesis of various inflammatory disorders. In this study, we establish an in vitro binding assay in which recombinant human high-mobility group box 1 (rhHMGB1) or recombinant human S100A12 (rhS100A12) immobilized on the microplate binds to recombinant soluble RAGE (rsRAGE). The rsRAGE binding to both rhHMGB1 and rhS100A12 was saturable and dependent on the immobilized ligands. The binding of rsRAGE to rhS100A12 depended on Ca2 and Zn2, whereas that to rhHMGB1 was not. Scatchard plot analysis showed that rsRAGE had higher affinity for rhHMGB1 than for rhS100A12. rsRAGE was demonstrated to bind to heparin, and rhS100A12, in the presence of Ca2, was also found to bind to heparin. We examined the effects of heparin preparations with different molecular sizesunfractionated native heparin (UFH), low molecular weight heparin (LMWH) 5000Da, and LMWH 3000Da on the binding of rsRAGE to rhHMGB1 and rhS100A12. All 3 preparations concentration-dependently inhibited the binding of rsRAGE to rhHMGB1 to a greater extent than did rhS100A12. These results suggested that heparin's anti-inflammatory effects can be partly explained by its blocking of the interaction between HMGB1 or S100A12 and RAGE. On the other hand, heparin would be a promising effective remedy against RAGE-related inflammatory disorders. |
Keywords | RAGE HMGB1 S100A12 heparin inflammation |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2009-08 |
Volume | volume63 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 203 |
End Page | 211 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 19727205 |
Web of Science KeyUT | 000269228400006 |
FullText URL | fulltext.pdf |
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Author | Kawanoue, Naoya| Kuroda, Kosuke| Yasuda, Hiroko| Oiwa, Masahiko| Suzuki, Satoshi| Wake, Hidenori| Hosoi, Hiroki| Nishibori, Masahiro| Morimatsu, Hiroshi| |
Published Date | 2023-03-29 |
Publication Title | PLoS ONE |
Volume | volume18 |
Issue | issue3 |
Publisher | Public Library of Science |
Start Page | e0283426 |
ISSN | 1932-6203 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 Kawanoue et al. |
File Version | publisher |
PubMed ID | 36989333 |
DOI | 10.1371/journal.pone.0283426 |
Web of Science KeyUT | 000987475800001 |
Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0283426 |