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ID 57366
JaLCDOI
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Thumnail 73_5_379.pdf 1.96 MB
Author
Wake, Hidenori Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Abstract
Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding and functional properties of HRG in sepsis.
Keywords
htidine-rich glycoprotein
septic pathogenesis
immunothrombosis
Amo Type
Review
Published Date
2019-10
Publication Title
Acta Medica Okayama
Volume
volume73
Issue
issue5
Publisher
Okayama University Medical School
Start Page
379
End Page
382
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2019 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT