Tazawa, Hiroshi - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

テロメラーゼ依存的腫瘍融解アデノウイルス製剤による放射線感受性増強作用

Author	Kuroda, Shinji\| Fujiwara, Toshiya\| Shirakawa, Yasuhiro\| Yamasaki, Yasumoto\| Yano, Syuya\| Uno, Futoshi\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Watanabe, Yuichi\| Noma, Kazuhiro\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Published Date	2011-08-01
Publication Title	岡山医学会雑誌
Volume	volume123
Issue	issue2
Content Type	Journal Article

テロメラーゼ依存性腫瘍融解ウイルス療法の骨・軟部肉腫に対する前臨床的検討

Author	Sasaki, Tsuyoshi\| Tazawa, Hiroshi\| Hasei, Jo\| Kunisada, Toshiyuki\| Yoshida, Aki\| Hashimoto, Yuuri\| Yano, Shuya\| Yoshida, Ryosuke\| Uno, Futoshi\| Kagawa, Shunsuke\| Morimoto, Yuki\| Urata, Yasuo\| Fujiwara, Toshiyoshi\| Ozaki, Toshifumi\|
Published Date	2012-08-01
Publication Title	岡山医学会雑誌
Volume	volume124
Issue	issue2
Content Type	Journal Article

A simple biological imaging system for detecting viable human circulating tumor cells

Author	Kojima, Toru\| Hashimoto, Yuuri\| Watanabe, Yuichi\| Kagawa, Shunsuke\| Uno, Futoshi\| Kuroda, Shinji\| Tazawa, Hiroshi\| Kyo, Satoru\| Mizuguchi, Hiroyuki\| Urata, Yasuo\| Tanaka, Noriaki\| Fujiwara, Toshiyoshi\|
Published Date	2009-10-01
Publication Title	The Journal of Clinical Investigation
Volume	volume119
Issue	issue10
Content Type	Journal Article

癌微小リンパ節転移を標的とするテロメラーゼ特異的制限増殖型ウイルス製剤の開発

Author	Kojima, Toru\| Watanabe, Yuichi\| Hashimoto, Yuuri\| Kuroda, Shinji\| Yamasaki, Yasumoto\| Yano, Shuya\| Tazawa, Hiroshi\| Uno, Futoshi\| Kagawa, Shunsuke\| Tanaka, Noriaki\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Published Date	2013-04-01
Publication Title	岡山医学会雑誌
Volume	volume125
Issue	issue1
Content Type	Journal Article

Mechanism of resistance to trastuzumab and molecular sensitization via ADCC activation by exogenous expression of HER2-extracellular domain in human cancer cells

Author	Yoshida, Ryosuke\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Yano, Shuya\| Onishi, Teppei\| Sasaki, Tsuyoshi\| Shirakawa, Yasuhiro\| Kishimoto, Hiroyuki\| Uno, Futoshi\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Published Date	2012-11
Publication Title	Cancer Immunology, Immunotherapy
Volume	volume61
Issue	issue11
Content Type	Journal Article

The hTERT Promoter Enhances the Antitumor Activity of an Oncolytic Adenovirus under a Hypoxic Microenvironment

Author	Hashimoto, Yuuri\| Tazawa, Hiroshi\| Teraishi, Fuminori\| Kojima, Toru\| Watanabe, Yuichi\| Uno, Futoshi\| Yano, Shuya\| Urata, Yasuo\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Published Date	2012-06-15
Publication Title	PLoS ONE
Volume	volume7
Issue	issue6
Content Type	Journal Article

Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author	Hasei, Joe\| Sasaki, Tsuyoshi\| Tazawa, Hiroshi\| Osaki, Shuhei\| Yamakawa, Yasuaki\| Kunisada, Toshiyuki\| Yoshida, Aki\| Hashimoto, Yuuri\| Onishi, Teppei\| Uno, Futoshi\| Kagawa, Shunsuke\| Urata, Yasuo\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
Published Date	2013-03
Publication Title	Molecular Cancer Therapeutics
Volume	volume12
Issue	issue3
Content Type	Journal Article

腫瘍融解アデノウイルスによるE2F1-マイクロRNA-7-EGFR経路を介したオートファジー細胞死の誘導分子機構

Author	Tazawa, Hiroshi\| Yano, Syuya\| Yoshida, Ryosuke\| Yamasaki, Yasumoto\| Sasaki, Tsuyoshi\| Hashimoto, Yuuri\| Kuroda, Shinji\| Ouchi, Masaaki\| Onishi, Teppei\| Uno, Futoshi\| Kagawa, Syunsuke\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Published Date	2013-12-02
Publication Title	岡山医学会雑誌
Volume	volume125
Issue	issue3
Content Type	Journal Article

Oncolytic Adenovirus-Induced Autophagy: Tumor-Suppressive Effect and Molecular Basis

JaLCDOI	10.18926/AMO/52006
FullText URL	67_6_333.pdf
Author	Tazawa, Hiroshi\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Abstract	Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the E1-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses.
Keywords	oncolytic adenovirus autophagy E2F1 microRNA
Amo Type	Review
Publication Title	Acta Medica Okayama
Published Date	2013-12
Volume	volume67
Issue	issue6
Publisher	Okayama University Medical School
Start Page	333
End Page	342
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2013 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	24356717
Web of Science KeyUT	000328915700001

A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem-like Cells in S/G(2)/M Phases

Author	Yano, Shuya\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Shirakawa, Yasuhiro\| Kuroda, Shinji\| Nishizaki, Masahiko\| Kishimoto, Hiroyuki\| Uno, Futoshi\| Nagasaka, Takeshi\| Urata, Yasuo\| Kagawa, Shunsuke\| Hoffman, Robert M.\| Fujiwara, Toshiyoshi\|
Published Date	2013-12-01
Publication Title	Clinical Cancer Research
Volume	volume19
Issue	issue23
Content Type	Journal Article

Fluorescence virus-guided capturing system of human colorectal circulating tumour cells for non-invasive companion diagnostics

Author	Shigeyasu, Kunitoshi\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Mori, Yoshiko\| Nishizaki, Masahiko\| Kishimoto, Hiroyuki\| Nagasaka, Takeshi\| Kuroda, Shinji\| Urata, Yasuo\| Goel, Ajay\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Published Date	2014-05-28
Publication Title	Gut
Content Type	Journal Article

Biological Ablation of Sentinel Lymph Node Metastasis in Submucosally Invaded Early Gastrointestinal Cancer

Author	Kikuchi, Satoru\| Kishimoto, Hiroyuki\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Kuroda, Shinji\| Nishizaki, Masahiko\| Nagasaka, Takeshi\| Shirakawa, Yasuhiro\| Kagawa, Shunsuke\| Urata, Yasuo\| Robert M Hoffman\| Fujiwara, Toshiyoshi\|
Published Date	2014-12-19
Publication Title	Molecular Therapy
Content Type	Journal Article

Intraperitoneal cancer-immune microenvironment promotes peritoneal dissemination of gastric cancer

FullText URL	OncoImmunol_8_12_1671760.pdf
Author	Sakamoto, Shuichi\| Kagawa, Shunsuke\| Kuwada, Kazuya\| Ito, Atene\| Kajioka, Hiroki\| Kakiuchi, Yoshihiko\| Watanabe, Megumi\| Kagawa, Tetsuya\| Yoshida, Ryuichi\| Kikuchi, Satoru\| Kuroda, Shinji\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Keywords	Gastric cancer tumor-associated macrophages tumor microenvironment peritoneal dissemination
Published Date	2019-10-22
Publication Title	OncoImmunology
Volume	volume8
Issue	issue12
Publisher	TAYLOR & FRANCIS
Start Page	e1671760
ISSN	2162402X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 The Author(s).
File Version	publisher
DOI	10.1080/2162402X.2019.1671760
Web of Science KeyUT	000494085400001
Related Url	isVersionOf https://doi.org/10.1080/2162402X.2019.1671760

A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness

FullText URL	cancers_11_2_177.pdf
Author	Katsura, Yuki\| Ohara, Toshiaki\| Noma, Kazuhiro\| Ninomiya, Takayuki\| Kashima, Hajime\| Kato, Takuya\| Sato, Hiroaki\| Komoto, Satoshi\| Narusaka, Toru\| Tomono, Yasuko\| Xing, Boyi\| Chen, Yuehua\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Kasai , Tomonari\| Seno, Masaharu\| Matsukawa, Akihiro\| Fujiwara, Toshiyoshi\|
Keywords	cancer stem cells combination therapy iron stemness
Published Date	2019-02-03
Publication Title	Cancers
Volume	volume11
Issue	issue2
Publisher	MDPI
Start Page	177
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 by the authors
File Version	publisher
PubMed ID	30717462
DOI	10.3390/cancers11020177
Web of Science KeyUT	000460747200051
Related Url	isVersionOf https://doi.org/10.3390/cancers11020177

PD-L1 expression combined with microsatellite instability/CD8+tumor infiltrating lymphocytes as a useful prognostic biomarker in gastric cancer

FullText URL	SR9_1_4633.pdf
Author	Morihiro, Toshiaki\| Kuroda, Shinji\| Kanaya, Nobuhiko\| Kakiuchi, Yoshihiko\| Kubota, Tetsushi\| Aoyama, Katsuyuki\| Tanaka, Takehiro\| Kikuch, Satoru\| Nagasaka, Takeshi\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Published Date	2019-3-15
Publication Title	Scientific Reports
Volume	volume9
Publisher	Nature Publishing Group
Start Page	4633
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2019
File Version	publisher
PubMed ID	30874607
DOI	10.1038/s41598-019-41177-2
Web of Science KeyUT	000461303000015
Related Url	isVersionOf https://doi.org/10.1038/s41598-019-41177-2

Visualization of epithelial-mesenchymal transition in an inflammatory microenvironment-colorectal cancer network

Author	Ieda, Takeshi\| Tazawa, Hiroshi\| Okabayashi, Hiroki\| Yano, Shuya\| Shigeyasu, Kunitoshi\| Kuroda, Shinji\| Ohara, Toshiaki\| Noma, Kazuhiro\| Kishimoto, Hiroyuki\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Saitou, Takashi\| Imamura, Takeshi\| Fujiwara, Toshiyoshi\|
Published Date	2019-11-8
Publication Title	Scientific Reports
Volume	volume9
Publisher	Nature Publishing Group
Start Page	16378
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2019
File Version	publisher
PubMed ID	31705021
DOI	10.1038/s41598-019-52816-z
Web of Science KeyUT	000495372900001
Related Url	isVersionOf https://doi.org/10.1038/s41598-019-52816-z

Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody

FullText URL	fulltext.pdf Graphical_Abstract.pptx Figure1-6.pdf Supp_Info.pdf
Author	Kanaya, Nobuhiko\| Kuroda, Shinji\| Kakiuchi, Yoshihiko\| Kumon, Kento\| Tsumura, Tomoko\| Hashimoto, Masashi\| Morihiro, Toshiaki\| Kubota, Tetsushi\| Aoyama, Katsuyuki\| Kikuchi, Satoru\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Tazawa, Hiroshi\| Mizuguchi, Hiroyuki\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Keywords	immune checkpoint programmed death-1 oncolytic adenovirus combined immunotherapy immunogenic cell death tumor infiltrating lymphocytes CD8 abscopal effect
Published Date	2020-01-10
Publication Title	Molecular Therapy
Volume	volume28
Issue	issue3
Publisher	Cell Press
Start Page	794
End Page	804
ISSN	15250016
NCID	AA11475060
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	31991110
DOI	10.1016/j.ymthe.2020.01.003
Web of Science KeyUT	000518887200012
Related Url	isVersionOf https://doi.org/10.1016/j.ymthe.2020.01.003

Bone and Soft-Tissue Sarcoma: A New Target for Telomerase-Specific Oncolytic Virotherapy

FullText URL	fulltext.pdf
Author	Tazawa, Hiroshi\| Hasei, Joe\| Yano, Shuya\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
Keywords	oncolytic adenovirus hTERT autophagy GFP p53
Published Date	2020-02-18
Publication Title	Cancers
Volume	volume12
Issue	issue2
Publisher	MDPI
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 by the authors.
File Version	publisher
PubMed ID	32085583
DOI	10.3390/cancers12020478
Web of Science KeyUT	000522477300224
Related Url	isVersionOf https://doi.org/10.3390/cancers12020478

Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer

FullText URL	fulltext.pdf
Author	Koujima, Takeshi\| Tazawa, Hiroshi\| Ieda, Takeshi\| Araki, Hiroyuki\| Fushimi, Takuro\| Shoji, Ryohei\| Kuroda, Shinji\| Kikuchi, Satoru\| Yoshida, Ryuichi\| Umeda, Yuzo\| Teraishi, Fuminori\| Urata, Yasuo\| Mizuguchi, Hiroyuki\| Fujiwara, Toshiyoshi\|
Published Date	2020-06-26
Publication Title	Molecular Therapy - Oncolytics
Volume	volume17
Publisher	Cell Press
Start Page	107
End Page	117
ISSN	2372-7705
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 The Author(s).
File Version	publisher
PubMed ID	32322667
DOI	10.1016/j.omto.2020.03.016
Web of Science KeyUT	000544101600010
Related Url	isVersionOf https://doi.org/10.1016/j.omto.2020.03.016

Boosting Replication and Penetration of Oncolytic Adenovirus by Paclitaxel Eradicate Peritoneal Metastasis of Gastric Cancer

FullText URL	fulltext.pdf
Author	Ishikawa, Wataru\| Kikuchi, Satoru\| Ogawa, Toshihiro\| Tabuchi, Motoyasu\| Tazawa, Hiroshi\| Kuroda, Shinji\| Noma, Kazuhiro\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Keywords	peritoneal metastasis adenovirus gastric cancer intraperitoneal chemotherapy paclitaxel oncolytic virus
Published Date	2020-09-25
Publication Title	Molecular Therapy - Oncolytics
Volume	volume18
Publisher	Cell Press
Start Page	262
End Page	271
ISSN	2372-7705
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 The Author(s).
File Version	publisher
PubMed ID	32728614
DOI	10.1016/j.omto.2020.06.021
Web of Science KeyUT	000575168700023
Related Url	isVersionOf https://doi.org/10.1016/j.omto.2020.06.021