Tazawa, Hiroshi - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer

FullText URL	fulltext.pdf
Author	Koujima, Takeshi\| Tazawa, Hiroshi\| Ieda, Takeshi\| Araki, Hiroyuki\| Fushimi, Takuro\| Shoji, Ryohei\| Kuroda, Shinji\| Kikuchi, Satoru\| Yoshida, Ryuichi\| Umeda, Yuzo\| Teraishi, Fuminori\| Urata, Yasuo\| Mizuguchi, Hiroyuki\| Fujiwara, Toshiyoshi\|
Published Date	2020-06-26
Publication Title	Molecular Therapy - Oncolytics
Volume	volume17
Publisher	Cell Press
Start Page	107
End Page	117
ISSN	2372-7705
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 The Author(s).
File Version	publisher
PubMed ID	32322667
DOI	10.1016/j.omto.2020.03.016
Web of Science KeyUT	000544101600010
Related Url	isVersionOf https://doi.org/10.1016/j.omto.2020.03.016

Oncolytic Adenovirus-Induced Autophagy: Tumor-Suppressive Effect and Molecular Basis

JaLCDOI	10.18926/AMO/52006
FullText URL	67_6_333.pdf
Author	Tazawa, Hiroshi\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Abstract	Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the E1-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses.
Keywords	oncolytic adenovirus autophagy E2F1 microRNA
Amo Type	Review
Publication Title	Acta Medica Okayama
Published Date	2013-12
Volume	volume67
Issue	issue6
Publisher	Okayama University Medical School
Start Page	333
End Page	342
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2013 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	24356717
Web of Science KeyUT	000328915700001

Modulation of p53 expression in cancer-associated fibroblasts prevents peritoneal metastasis of cancer

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Author	Ogawa, Toshihiro\| Kikuchi, Satoru\| Tabuchi, Motoyasu\| Mitsui, Ema\| Une, Yuta\| Tazawa, Hiroshi\| Kuroda, Shinji\| Noma, Kazuhiro\| Ohara, Toshiaki\| Kagawa, Shunsuke\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Published Date	2022-06-16
Publication Title	Molecular Therapy-Oncolytics
Volume	volume25
Publisher	Cell Press
Start Page	249
End Page	261
ISSN	2372-7705
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Author(s).
File Version	publisher
PubMed ID	35615263
DOI	10.1016/j.omto.2022.04.009
Web of Science KeyUT	000800437000008
Related Url	isVersionOf https://doi.org/10.1016/j.omto.2022.04.009

Mechanism of resistance to trastuzumab and molecular sensitization via ADCC activation by exogenous expression of HER2-extracellular domain in human cancer cells

Author	Yoshida, Ryosuke\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Yano, Shuya\| Onishi, Teppei\| Sasaki, Tsuyoshi\| Shirakawa, Yasuhiro\| Kishimoto, Hiroyuki\| Uno, Futoshi\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Published Date	2012-11
Publication Title	Cancer Immunology, Immunotherapy
Volume	volume61
Issue	issue11
Content Type	Journal Article

Long-term activation of anti-tumor immunity in pancreatic cancer by a p53-expressing telomerase-specific oncolytic adenovirus

FullText URL	fulltext20240219-05.pdf
Author	Hashimoto, Masashi\| Kuroda, Shinji\| Kanaya, Nobuhiko\| Kadowaki, Daisuke\| Yoshida, Yusuke\| Sakamoto, Masaki\| Hamada, Yuki\| Sugimoto, Ryoma\| Yagi, Chiaki\| Ohtani, Tomoko\| Kumon, Kento\| Kakiuchi, Yoshihiko\| Yasui, Kazuya\| Kikuchi, Satoru\| Yoshida, Ryuichi\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Yagi, Takahito\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Note	The version of record of this article, first published in British Journal of Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41416-024-02583-0\|
Published Date	2024-02-05
Publication Title	British Journal of Cancer
Volume	volume130
Issue	issue7
Publisher	Springer Science and Business Media LLC
Start Page	1187
End Page	1195
ISSN	0007-0920
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024
File Version	publisher
PubMed ID	38316993
DOI	10.1038/s41416-024-02583-0
Web of Science KeyUT	001156904400001
Related Url	isVersionOf https://doi.org/10.1038/s41416-024-02583-0

Local oncolytic adenovirotherapy produces an abscopal effect via tumor-derived extracellular vesicles

FullText URL	fulltext20211015-3.pdf figure20211015-3.pdf Suppl_Information20211015-3.pdf
Author	Kakiuchi, Yoshihiko\| Kuroda, Shinji\| Kanaya, Nobuhiko\| Kumon, Kento\| Tsumura, Tomoko\| Hashimoto, Masashi\| Yagi, Chiaki\| Sugimoto, Ryoma\| Hamada, Yuki\| Kikuchi, Satoru\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Tazawa, Hiroshi\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Keywords	Extracellular vesicles Exosome Abscopal effect Oncolytic adenovirus Local treatment Systemic delivery Drug delivery system
Note	© 2021 The American Society of Gene and Cell Therapy. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ymthe.2021.05.015] .\|
Published Date	2021-05-21
Publication Title	Molecular Therapy
Volume	volume29
Issue	issue10
Publisher	The American Society of Gene and Cell Therapy
Start Page	2920
End Page	2930
ISSN	15250016
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The American Society of Gene and Cell Therapy.
File Version	author
PubMed ID	34023506
DOI	10.1016/j.ymthe.2021.05.015
Web of Science KeyUT	000708324600008
Related Url	isVersionOf https://doi.org/10.1016/j.ymthe.2021.05.015

Intraperitoneal cancer-immune microenvironment promotes peritoneal dissemination of gastric cancer

FullText URL	OncoImmunol_8_12_1671760.pdf
Author	Sakamoto, Shuichi\| Kagawa, Shunsuke\| Kuwada, Kazuya\| Ito, Atene\| Kajioka, Hiroki\| Kakiuchi, Yoshihiko\| Watanabe, Megumi\| Kagawa, Tetsuya\| Yoshida, Ryuichi\| Kikuchi, Satoru\| Kuroda, Shinji\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Keywords	Gastric cancer tumor-associated macrophages tumor microenvironment peritoneal dissemination
Published Date	2019-10-22
Publication Title	OncoImmunology
Volume	volume8
Issue	issue12
Publisher	TAYLOR & FRANCIS
Start Page	e1671760
ISSN	2162402X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 The Author(s).
File Version	publisher
DOI	10.1080/2162402X.2019.1671760
Web of Science KeyUT	000494085400001
Related Url	isVersionOf https://doi.org/10.1080/2162402X.2019.1671760

Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody

FullText URL	fulltext.pdf Graphical_Abstract.pptx Figure1-6.pdf Supp_Info.pdf
Author	Kanaya, Nobuhiko\| Kuroda, Shinji\| Kakiuchi, Yoshihiko\| Kumon, Kento\| Tsumura, Tomoko\| Hashimoto, Masashi\| Morihiro, Toshiaki\| Kubota, Tetsushi\| Aoyama, Katsuyuki\| Kikuchi, Satoru\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Tazawa, Hiroshi\| Mizuguchi, Hiroyuki\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Keywords	immune checkpoint programmed death-1 oncolytic adenovirus combined immunotherapy immunogenic cell death tumor infiltrating lymphocytes CD8 abscopal effect
Published Date	2020-01-10
Publication Title	Molecular Therapy
Volume	volume28
Issue	issue3
Publisher	Cell Press
Start Page	794
End Page	804
ISSN	15250016
NCID	AA11475060
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	31991110
DOI	10.1016/j.ymthe.2020.01.003
Web of Science KeyUT	000518887200012
Related Url	isVersionOf https://doi.org/10.1016/j.ymthe.2020.01.003

Fluorescence virus-guided capturing system of human colorectal circulating tumour cells for non-invasive companion diagnostics

Author	Shigeyasu, Kunitoshi\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Mori, Yoshiko\| Nishizaki, Masahiko\| Kishimoto, Hiroyuki\| Nagasaka, Takeshi\| Kuroda, Shinji\| Urata, Yasuo\| Goel, Ajay\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\|
Published Date	2014-05-28
Publication Title	Gut
Content Type	Journal Article

Fibroblast activation protein targeted near infrared photoimmunotherapy (NIR PIT) overcomes therapeutic resistance in human esophageal cancer

FullText URL	fulltext.pdf
Author	Katsube, Ryoichi\| Noma, Kazuhiro\| Ohara, Toshiaki\| Nishiwaki, Noriyuki\| Kobayashi, Teruki\| Komoto, Satoshi\| Sato, Hiroaki\| Kashima, Hajime\| Kato, Takuya\| Kikuchi, Satoru\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Kobayashi, Hisataka\| Fujiwara, Toshiyoshi\|
Published Date	2021-01-18
Publication Title	Scientific Reports
Volume	volume11
Issue	issue1
Publisher	Nature Research
Start Page	1693
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2021
File Version	publisher
PubMed ID	33462372
DOI	10.1038/s41598-021-81465-4
Web of Science KeyUT	000612156600008
Related Url	isVersionOf https://doi.org/10.1038/s41598-021-81465-4

FUCCI Real-Time Cell-Cycle Imaging as a Guide for Designing Improved Cancer Therapy: A Review of Innovative Strategies to Target Quiescent Chemo-Resistant Cancer Cells

FullText URL	fulltext.pdf
Author	Yano, Shuya\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Fujiwara, Toshiyoshi\| Hoffman, Robert M.\|
Keywords	cell cycle fluorescent proteins FUCCI imaging targeted cancer therapy quiescent cancer cells decoy chemotherapy
Published Date	2020-09-17
Publication Title	Cancers
Volume	volume12
Issue	issue9
Publisher	MDPI
Start Page	2655
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 by the authors.
File Version	publisher
PubMed ID	32957652
DOI	10.3390/cancers12092655
Web of Science KeyUT	000580315800001
Related Url	isVersionOf https://doi.org/10.3390/cancers12092655

Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation

FullText URL	fulltext.pdf
Author	Ito, Atene\| Kagawa, Shunsuke\| Sakamoto, Shuichi\| Kuwada, Kazuya\| Kajioka, Hiroki\| Yoshimoto, Masashi\| Kikuchi, Satoru\| Kuroda, Shinji\| Yoshida, Ryuichi\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Keywords	Extracellular vesicles Gastric cancer Tumor-associated macrophages Tumor microenvironment
Published Date	2021-01-28
Publication Title	BMC Cancer
Volume	volume21
Issue	issue1
Publisher	BMC
Start Page	102
ISSN	1471-2407
NCID	AA12034763
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s). 2021
File Version	publisher
PubMed ID	33509150
DOI	10.1186/s12885-021-07816-6
Web of Science KeyUT	000615987400002
Related Url	isVersionOf https://doi.org/10.1186/s12885-021-07816-6

Elimination of MYCN-Amplified Neuroblastoma Cells by Telomerase-Targeted Oncolytic Virus via MYCN Suppression

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Author	Tanimoto, Terutaka\| Tazawa, Hiroshi\| Ieda, Takeshi\| Nouso, Hiroshi\| Tani, Morimichi\| Oyama, Takanori\| Urata, Yasuo\| Kagawa, Shunsuke\| Noda, Takuo\| Fujiwara, Toshiyoshi\|
Keywords	neuroblastoma MYCN hTERT adenovirus E2F1
Published Date	2020-09-25
Publication Title	Molecular Therapy - Oncolytics
Volume	volume18
Publisher	Cell Press
Start Page	14
End Page	23
ISSN	2372-7705
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 The Author(s).
File Version	publisher
PubMed ID	32637577
DOI	10.1016/j.omto.2020.05.015
Web of Science KeyUT	000575168700002
Related Url	isVersionOf https://doi.org/10.1016/j.omto.2020.05.015

Dual-targeted near-infrared photoimmunotherapy for esophageal cancer and cancer-associated fibroblasts in the tumor microenvironment

FullText URL	fulltext.pdf
Author	Sato, Hiroaki\| Noma, Kazuhiro\| Ohara, Toshiaki\| Kawasaki, Kento\| Akai, Masaaki\| Kobayashi, Teruki\| Nishiwaki, Noriyuki\| Narusaka, Toru\| Komoto, Satoshi\| Kashima, Hajime\| Katsura, Yuki\| Kato, Takuya\| Kikuchi, Satoru\| Tazawa, Hiroshi\| Kagawa, Shunsuke\| Shirakawa, Yasuhiro\| Kobayashi, Hisataka\| Fujiwara, Toshiyoshi\|
Published Date	2022-11-23
Publication Title	Scientific Reports
Volume	volume12
Issue	issue1
Publisher	Nature Portfolio
Start Page	20152
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022
File Version	publisher
PubMed ID	36418422
DOI	10.1038/s41598-022-24313-3
Web of Science KeyUT	000887936300054
Related Url	isVersionOf https://doi.org/10.1038/s41598-022-24313-3

Dual antiplatelet therapy inhibits neutrophil extracellular traps to reduce liver micrometastases of intrahepatic cholangiocarcinoma

Author	Yoshimoto, Masashi\| Kagawa, Shunsuke\| Kajioka, Hiroki\| Taniguchi, Atsuki\| Kuroda, Shinji\| Kikuchi, Satoru\| Kakiuchi, Yoshihiko\| Yagi, Tomohiko\| Nogi, Shohei\| Teraishi, Fuminori\| Shigeyasu, Kunitoshi\| Yoshida, Ryuichi\| Umeda, Yuzo\| Noma, Kazuhiro\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Keywords	Aspirin Ticagrelor P-selectin Platelet Time-lapse imaging
Note	© 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/\| This fulltext file will be available in Jul. 2024.\|
Published Date	2023-07-28
Publication Title	Cancer Letters
Volume	volume567
Publisher	Elsevier BV
Start Page	216260
ISSN	0304-3835
NCID	AA00598513
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 Elsevier B.V.
File Version	author
PubMed ID	37295551
DOI	10.1016/j.canlet.2023.216260
Web of Science KeyUT	001020524700001
Related Url	isVersionOf https://doi.org/10.1016/j.canlet.2023.216260

Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Author	Hasei, Joe\| Sasaki, Tsuyoshi\| Tazawa, Hiroshi\| Osaki, Shuhei\| Yamakawa, Yasuaki\| Kunisada, Toshiyuki\| Yoshida, Aki\| Hashimoto, Yuuri\| Onishi, Teppei\| Uno, Futoshi\| Kagawa, Shunsuke\| Urata, Yasuo\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
Published Date	2013-03
Publication Title	Molecular Cancer Therapeutics
Volume	volume12
Issue	issue3
Content Type	Journal Article

Conventional Cancer Therapies Can Accelerate Malignant Potential of Cancer Cells by Activating Cancer-Associated Fibroblasts in Esophageal Cancer Models

FullText URL	fulltext.pdf
Author	Komoto, Satoshi\| Noma, Kazuhiro\| Kato, Takuya\| Kobayashi, Teruki\| Nishiwaki, Noriyuki\| Narusaka, Toru\| Sato, Hiroaki\| Katsura, Yuki\| Kashima, Hajime\| Kikuchi, Satoru\| Ohara, Toshiaki\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Keywords	cancer-associated fibroblast chemotherapy radiotherapy esophageal cancer tumor microenvironment
Published Date	2023-05-30
Publication Title	Cancers
Volume	volume15
Issue	issue11
Publisher	MDPI
Start Page	2971
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	37296933
DOI	10.3390/cancers15112971
Web of Science KeyUT	001006082400001
Related Url	isVersionOf https://doi.org/10.3390/cancers15112971

Boosting Replication and Penetration of Oncolytic Adenovirus by Paclitaxel Eradicate Peritoneal Metastasis of Gastric Cancer

FullText URL	fulltext.pdf
Author	Ishikawa, Wataru\| Kikuchi, Satoru\| Ogawa, Toshihiro\| Tabuchi, Motoyasu\| Tazawa, Hiroshi\| Kuroda, Shinji\| Noma, Kazuhiro\| Nishizaki, Masahiko\| Kagawa, Shunsuke\| Urata, Yasuo\| Fujiwara, Toshiyoshi\|
Keywords	peritoneal metastasis adenovirus gastric cancer intraperitoneal chemotherapy paclitaxel oncolytic virus
Published Date	2020-09-25
Publication Title	Molecular Therapy - Oncolytics
Volume	volume18
Publisher	Cell Press
Start Page	262
End Page	271
ISSN	2372-7705
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 The Author(s).
File Version	publisher
PubMed ID	32728614
DOI	10.1016/j.omto.2020.06.021
Web of Science KeyUT	000575168700023
Related Url	isVersionOf https://doi.org/10.1016/j.omto.2020.06.021

Bone and Soft-Tissue Sarcoma: A New Target for Telomerase-Specific Oncolytic Virotherapy

FullText URL	fulltext.pdf
Author	Tazawa, Hiroshi\| Hasei, Joe\| Yano, Shuya\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
Keywords	oncolytic adenovirus hTERT autophagy GFP p53
Published Date	2020-02-18
Publication Title	Cancers
Volume	volume12
Issue	issue2
Publisher	MDPI
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 by the authors.
File Version	publisher
PubMed ID	32085583
DOI	10.3390/cancers12020478
Web of Science KeyUT	000522477300224
Related Url	isVersionOf https://doi.org/10.3390/cancers12020478

Biological Ablation of Sentinel Lymph Node Metastasis in Submucosally Invaded Early Gastrointestinal Cancer

Author	Kikuchi, Satoru\| Kishimoto, Hiroyuki\| Tazawa, Hiroshi\| Hashimoto, Yuuri\| Kuroda, Shinji\| Nishizaki, Masahiko\| Nagasaka, Takeshi\| Shirakawa, Yasuhiro\| Kagawa, Shunsuke\| Urata, Yasuo\| Robert M Hoffman\| Fujiwara, Toshiyoshi\|
Published Date	2014-12-19
Publication Title	Molecular Therapy
Content Type	Journal Article