JaLCDOI | 10.18926/AMO/66676 |
---|---|
FullText URL | 78_1_089.pdf |
Author | Toshima, Kei| Shien, Tadahiko| Nishimura, Midori Filiz| Suzuki, Yoko| Nakamoto, Shogo| Uno, Maya| Yoshioka, Ryo| Tsukioki, Takahiro| Takahashi, Yuko| Iwamoto, Takayuki| Iwatani, Tsuguo| Yanai, Hiroyuki| |
Abstract | We report our experience with the diagnosis and treatment of an ectopic breast cancer arising within an axillary lymph node. The patient was a 65-year-old woman diagnosed breast cancer and axillary lymph node metastasis. We performed a partial mastectomy and axillary lymph node dissection. Postoperative pathology revealed no malignant lesions in the breast; however, a nodule in one of axillary lymph nodes had mixed benign and malignant components, leading to a diagnosis of invasive ductal carcinoma derived from ectopic mammary tissue. This case represents a very rare form of breast cancer, and the malignancy was difficult to distinguish from metastasis. |
Keywords | breast cancer ectopic breast cancer axillary lymph node |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2024-02 |
Volume | volume78 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 89 |
End Page | 93 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
JaLCDOI | 10.18926/AMO/66666 |
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FullText URL | 78_1_015.pdf |
Author | Maeda, Reina| Shien, Tadahiko| Takahashi, Mina| Kawada, Kengo| Kajiwara, Yukiko| Kubo, Shinichiro| Takabatake, Daisuke| Ohtani, Shoichiro| Matsuoka, Kinya| Hikino, Hajime| Ogasawara, Yutaka| Taira, Naruto| Osumi, Shozo| Ikeda, Masahiko| Doihara, Hiroyoshi| |
Abstract | While local treatment of metastases is considered to be unrelated to prognosis, previous studies have suggested that local treatment of isolated lung metastases may have positive prognostic impact. We designed this prospective cohort study to investigate the clinical situation and its outcomes. We enrolled patients with fewer than 3 lung nodules suspected of being oligometastases after curative breast cancer surgery. Treatments, including local and systemic therapy, were selected by the physician and patient in consultation. The primary outcome was overall survival (OS); secondary outcomes were the efficacy and the safety of the surgery for lung oligometastases. Between May 2015 and May 2019, 14 patients were enrolled. Resection of lung nodules (metastasectomy) was performed in 11 (78.6%) of 14 patients, and one of these cases was diagnosed as primary lung cancer. Metastasectomies were all performed employing video-assisted thoracic surgery (VATS) without perioperative complications. Systemic therapies were administered to all patients except one. The respective 3-year and 5-year OS rates of patients with lung oligometastases were 91.6% and 81.5%, respectively. Progression occurred in 6 patients: 3 of the 10 with metastasectomy and all 3 without this surgical procedure. Lung metastasectomy was worthwhile as a diagnostic evaluation and may provide long-term benefit in some patients. |
Keywords | oligometastasis breast cancer lung metastasectomy |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2024-02 |
Volume | volume78 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 15 |
End Page | 20 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
FullText URL | fulltext.pdf |
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Author | Tsukioki, Takahiro| Khan, Seema A.| Shien, Tadahiko| |
Keywords | Breast cancer Prevention Risk reduction mastectomy Chemoprevention Methylation |
Note | The version of record of this article, first published in Genes and Environment, is available online at Publisher’s website: http://dx.doi.org/10.1186/s41021-023-00287-0| |
Published Date | 2023-12-12 |
Publication Title | Genes and Environment |
Volume | volume45 |
Issue | issue1 |
Publisher | BMC |
Start Page | 35 |
ISSN | 1880-7046 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2023. |
File Version | publisher |
PubMed ID | 38082340 |
DOI | 10.1186/s41021-023-00287-0 |
Web of Science KeyUT | 001121724100001 |
Related Url | isVersionOf https://doi.org/10.1186/s41021-023-00287-0 |
JaLCDOI | 10.18926/AMO/64356 |
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FullText URL | 77_1_11.pdf |
Author | Watanabe, Satoko| Saiga, Miho| Motoki, Takayuki| Shien, Tadahiko| Taira, Naruto| Doihara, Hiroyoshi| Kimata, Yoshihiro| |
Abstract | The importance of a well-fitted, comfortable brassiere to overall quality of life after breast reconstruction has not been evaluated. Our aim was to determine the impact of a semi-customized brassiere on patients’ health-related quality of life after breast reconstruction. The subjects were prospective patients with mastectomy who were to undergo immediate or delayed breast reconstruction at our hospital. After surgery, a professional bra fitter sized each patient for a semi-customized brassiere and provided follow-up consultations. A self-reported questionnaire on breast aesthetics, postoperative pain, and satisfaction was used to assess the primary outcomes. Data were prospectively collected at baseline (before surgery) and at 1, 3, 6, and 12 months after surgery and analyzed. Forty-six patients (50 breasts) were included in the analysis. Consistent wearing of the brassiere reduced pain (p<0.05), with good overall satisfaction (p<0.001). Aesthetic scores on breast shape and size were higher with than without the custom brassiere at 3 months (p=0.02) and 6 months (p=0.03) after surgery. Wearing the brassiere reduced anxiety at all time points of measurement. A well-fitting brassiere ensured safety and provided a high degree of satisfaction without anxiety for patients after breast reconstruction. |
Keywords | breast reconstruction mastectomy brassiere professional bra fitter |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2023-02 |
Volume | volume77 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 11 |
End Page | 19 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 36849141 |
Web of Science KeyUT | 000953663800002 |
FullText URL | fulltext.pdf |
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Author | Ochi, Kosuke| Suzawa, Ken| Thu, Yin Min| Takatsu, Fumiaki| Tsudaka, Shimpei| Zhu, Yidan| Nakata, Kentaro| Takeda, Tatsuaki| Shien, Kazuhiko| Yamamoto, Hiromasa| Okazaki, Mikio| Sugimoto, Seiichiro| Shien, Tadahiko| Okamoto, Yoshiharu| Tomida, Shuta| Toyooka, Shinichi| |
Keywords | cancer-associated fibroblast drug resistance tranilast |
Published Date | 2022-07-24 |
Publication Title | Cancer Science |
Volume | volume2022 |
Publisher | Wiley |
ISSN | 1347-9032 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 The Authors. |
File Version | publisher |
PubMed ID | 35871750 |
DOI | 10.1111/cas.15502 |
Web of Science KeyUT | 000840374000001 |
Related Url | isVersionOf https://doi.org/10.1111/cas.15502 |
FullText URL | fulltext.pdf |
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Author | Fujihara, Miwa| Shien, Tadahiko| Shien, Kazuhiko| Suzawa, Ken| Takeda, Tatsuaki| Zhu, Yidan| Mamori, Tomoka| Otani, Yusuke| Yoshioka, Ryo| Uno, Maya| Suzuki, Yoko| Abe, Yuko| Hatono, Minami| Tsukioki, Takahiro| Takahashi, Yuko| Kochi, Mariko| Iwamoto, Takayuki| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi| |
Keywords | breast cancer YES1 T-DM1 dasatinib drug resistance |
Published Date | 2021-11-26 |
Publication Title | International Journal Of Molecular Sciences |
Volume | volume22 |
Issue | issue23 |
Publisher | MDPI |
Start Page | 12809 |
ISSN | 1422-0067 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 by the authors. |
File Version | publisher |
PubMed ID | 34884609 |
DOI | 10.3390/ijms222312809 |
Web of Science KeyUT | 000735641400001 |
Related Url | isVersionOf https://doi.org/10.3390/ijms222312809 |
JaLCDOI | 10.18926/AMO/60799 |
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FullText URL | 74_5_401.pdf |
Author | Tsukioki, Takahiro| Shien, Tadahiko| Ohtani, Yusuke| Fujihara, Miwa| Suzuki, Yoko| Kajihara, Yukiko| Hatono, Minami| Kawada, Kengo| Kochi, Mariko| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi| |
Abstract | Differentiated thyroid carcinoma (DTC) in juvenile patients is often an extensive and aggressive disease with a high frequency of recurrence. However, the prognosis is excellent, with a low mortality rate even when advanced disease is present, although prognostic factors and treatment strategy remain uncertain. Between April 2004 and March 2017, 33 juvenile patients (< 30 years old) were diagnosed with DTC and treated at our institution. We retrospectively investigated prognosis and factors including sex, reason for discovery, treatment, pathological factors and treatment progress to clarify the risk factors. All patients underwent curative surgical treatment. Pathologically, lymph node metastasis was identified in 25 patients (75%). Thirteen patients (39%) had bilateral cervical metastasis. In addition, 9 (27%) had more than 10 metastatic lymph nodes. The 2 patients with more than 20 metastatic lymph nodes were treated with radioactive iodine (RAI). Five patients (15%) had local recurrences and received surgery. There have been no further recurrences or deaths. However, no factors were determined to significantly predict the recurrence of juvenile DTC. Local recurrent disease was treated with surgery and/or RAI until remission, and survival was excellent in juvenile DTC. |
Keywords | differentiated thyroid carcinoma juvenile children |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2020-10 |
Volume | volume74 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 401 |
End Page | 406 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33106695 |
Web of Science KeyUT | 000581970100004 |
NAID | 120006892925 |
FullText URL | fulltext.pdf figure1.tif figure2.tif figure3.tif spfigure1.tif spfigure2.tif SupTable1.xlsx |
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Author | Ochi, Kosuke| Suzawa, Ken| Tomida, Shuta| Shien, Kazuhiko| Takano, Jui| Miyauchi, Shunsaku| Takeda, Tatsuaki| Miura, Akihiro| Araki, Kota| Nakata, Kentaro| Yamamoto, Hiromasa| Okazaki, Mikio| Sugimoto, Seiichiro| Shien, Tadahiko| Yamane, Masaomi| Azuma, Kazuo| Okamoto, Yoshiharu| Toyooka, Shinichi| |
Keywords | Monensin Epithelial-mesenchymal transition Non-small cell lung cancer Drug repositioning Drug resistance |
Note | This fulltext is available in Jul. 2021.| |
Published Date | 2020-08-27 |
Publication Title | Biochemical and Biophysical Research Communications |
Volume | volume529 |
Issue | issue3 |
Publisher | Academic Press |
Start Page | 760 |
End Page | 765 |
ISSN | 0006-291X |
NCID | AA00564395 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 32736704 |
DOI | 10.1016/j.bbrc.2020.06.077 |
Web of Science KeyUT | 000555780500037 |
Related Url | iaVersionOf https://doi.org/10.1016/j.bbrc.2020.06.077 |
FullText URL | fulltext.pdf |
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Author | Tsukioki, Takahiro| Shien, Tadahiko| Doihara, Hiroyoshi| |
Keywords | Breast cancer metastatic stage IV local therapy locoregional therapy surgery survival |
Published Date | 2020-08 |
Publication Title | Translational Cancer Research |
Volume | volume9 |
Issue | issue8 |
Publisher | AME Publishing Co. |
Start Page | 5102 |
End Page | 5107 |
ISSN | 2218-676X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © Translational Cancer Research. All rights reserved. |
File Version | publisher |
DOI | 10.21037/tcr.2020.01.60 |
Web of Science KeyUT | 000562138400067 |
Related Url | isVersionOf https://doi.org/10.21037/tcr.2020.01.60 |
FullText URL | CCP_fulltext.pdf |
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Author | Tsukioki, Takahiro| Shien, Tadahiko| Tanaka, Takehiro| Suzuki, Yoko| Kajihara, Yukiko| Hatono, Minami| Kawada, Kengo| Kochi, Mariko| Iwamoto, Takayuki| Ikeda, Hirokuni| Taira, Naruto| Doihara, Hiroyoshi| Toyooka, Shinichi| |
Keywords | Breast cancer Metformin Preoperative Tils CD8 PD-L1 |
Published Date | 2020-06-12 |
Publication Title | Cancer Chemotherapy and Pharmacology |
Volume | volume86 volume86 |
Issue | issue1 issue1 |
Publisher | Springer |
Start Page | 55 55 |
End Page | 63 63 |
ISSN | 0344-5704 |
NCID | AA00598397 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | ©Author(s) |
File Version | publisher |
PubMed ID | 32533334 |
DOI | 10.1007/s00280-020-04092-2 |
Web of Science KeyUT | 000539841500002 |
Related Url | isVersionOf https://doi.org/10.1007/s00280-020-04092-2 |
FullText URL | fulltext.pdf |
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Author | Iwamoto, Takayuki| Fujisawa, Tomomi| Shien, Tadahiko| Araki, Kazuhiro| Sakamaki, Kentaro| Sangai, Takafumi| Kikawa, Yuichiro| Takao, Shintaro| Nishimura, Reiki| Takahashi, Masato| Aihara, Tomohiko| Mukai, Hirofumi| aira, Naruto| |
Keywords | Metastatic breast cancer Endocrine therapies Estrogen receptor-positive HER2-negative Resistance |
Published Date | 2020-05-11 |
Publication Title | Breast Cancer |
Volume | volume27 |
Issue | issue5 |
Publisher | Springer |
Start Page | 973 |
End Page | 981 |
ISSN | 13406868 |
NCID | AA1103354X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 32394413 |
DOI | 10.1007/s12282-020-01095-y |
Web of Science KeyUT | 000531780600002 |
Related Url | isVersionOf https://doi.org/10.1007/s12282-020-01095-y |
FullText URL | fulltext.pdf |
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Author | Takahashi, Yuko| Iwamoto, Takayuki| Suzuki, Yoko| Kajiwara, Yukiko| Hatono, Minami| Tsukioki, Takahiro| Kawada, Kengo| Kochi, Mariko| Ikeda, Hirokuni| Shien, Tadahiko| Taira, Naruto| Matsuoka, Junji| Doihara, Hiroyoshi| Toyooka, Shinichi| |
Keywords | Gene expression Hormone receptor positive Residual tumor burden Targeted therapy Triple negative |
Published Date | 2020-04 |
Publication Title | Clinical Breast Cancer |
Volume | volume20 |
Issue | issue2 |
Publisher | Elsevier |
Start Page | 117 |
End Page | 124 |
ISSN | 1526-8209 |
NCID | AA11694891 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 31570267 |
DOI | 10.1016/j.clbc.2019.07.001 |
Web of Science KeyUT | 000529805200021 |
Related Url | isVersionOf https://doi.org/10.1016/j.clbc.2019.07.001 |
FullText URL | fulltext.pdf |
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Author | Shien, Tadahiko| Iwata, Hiroji| |
Keywords | breast cancer adjuvant neoadjuvant |
Note | This is a pre-copyedited, author-produced version of an article accepted for publication in Japanese Journal of Clinical Oncology following peer review. The version of record TTadahiko Shien, Hiroji Iwata, Adjuvant and neoadjuvant therapy for breast cancer, Japanese Journal of Clinical Oncology, Volume 50, Issue 3, March 2020, Pages 225–229 is available online at: https://doi.org/10.1093/jjco/hyz213.| |
Published Date | 2020-01-28 |
Publication Title | Japanese Journal of Clinical Oncology |
Volume | volume50 |
Issue | issue3 |
Publisher | Oxford University Press |
Start Page | 225 |
End Page | 229 |
ISSN | 0368-2811 |
NCID | AA00690866 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | Copyright © 2020 Oxford University Press |
File Version | author |
PubMed ID | 32147701 |
DOI | 10.1093/jjco/hyz213 |
Web of Science KeyUT | 000536439500001 |
Related Url | isVersionOf https://doi.org/10.1093/jjco/hyz213 |
FullText URL | fulltext.pdf |
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Author | Suzuki, Yoko| Taniguchi, Kohei| Hatono, Minami| Kajiwara, Yukiko| Abe, Yuko| Kawada, Kengo| Tsukioki, Takahiro| Kochi, Mariko| Nishiyama, Keiko| Iwamoto, Takayuki| Ikeda, Hirokuni| Shien, Tadahiko| Taira, Naruto| Tabata, Masahiro| Yanai, Hiroyuki| Doihara, Hiroyoshi| |
Keywords | Radiation-induced angiosarcoma Radiotherapy Breast-conserving surgery Breast cancer Paclitaxel therapy Adjuvant therapy of angiosarcoma |
Published Date | 2020-01-16 |
Publication Title | Surgical Case Reports |
Volume | volume6 |
Issue | issue1 |
Publisher | SpringerOpen |
Start Page | 25 |
ISSN | 2198-7793 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s). 2020 |
File Version | publisher |
PubMed ID | 31950295 |
DOI | 10.1186/s40792-020-0790-7 |
Web of Science KeyUT | 000513920900001 |
Related Url | isVersionOf https://doi.org/10.1186/s40792-020-0790-7 |
FullText URL | fulltext.pdf |
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Author | Takeda, Tatsuaki| Yamamoto, Hiromasa| Suzawa, Ken| Tomida, Shuta| Miyauchi, Shunsaku| Araki, Kota| Nakata, Kentaro| Miura, Akihiro| Namba, Kei| Shien, Kazuhiko| Soh, Junichi| Shien, Tadahiko| Kitamura, Yoshihisa| Sendo, Toshiaki| Toyooka, Shinichi| |
Keywords | breast cancer drug resistance lung cancer neratinib YES1 |
Published Date | 2019-12-19 |
Publication Title | Cancer Science |
Volume | volume111 |
Issue | issue3 |
Publisher | Wiley |
Start Page | 849 |
End Page | 856 |
ISSN | 1347-9032 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 The Authors. |
File Version | publisher |
PubMed ID | 31856375 |
DOI | 10.1111/cas.14289 |
Web of Science KeyUT | 000507433400001 |
Related Url | isVersionOf https://doi.org/10.1111/cas.14289 |
FullText URL | fulltext.pdf |
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Author | Shien, Tadahiko| |
Published Date | 2019-03 |
Publication Title | Translational Cancer Research |
Volume | volume8 |
Issue | issueSuppl. 2 |
Publisher | AME Publishing |
Start Page | S118 |
End Page | S119 |
ISSN | 2218-676X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | publisher |
DOI | 10.21037/tcr.2018.11.19 |
Related Url | isVersionOf https://doi.org/10.21037/tcr.2018.11.19 |
FullText URL | OL17_2_2177.pdf |
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Author | Miyoshi, Yuichiro| Shien, Tadahiko| Ogiya, Akiko| Ishida, Naoko| Yamazaki, Kieko| Horii, Rie| Horimoto, Yoshiya| Masuda, Norikazu| Yasojima, Hiroyuki| Inao, Touko| Osako, Tomofumi| Takahashi, Masato| Tomioka, Nobumoto| Wanifuchi‑Endo, Yumi| Hosoda, Mitsuchika| Doihara, Hiroyoshi| Yamashita, Hiroko| |
Keywords | breast cancer estrogen receptor positive human epidermal growth factor receptor type 2 negative prognosis tumor infiltrating lymphocytes |
Published Date | 2018-12-19 |
Publication Title | Oncology Letters |
Volume | volume17 |
Issue | issue2 |
Publisher | Spandidos Publications |
Start Page | 2177 |
End Page | 2186 |
ISSN | 1792-1074 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | publisher |
PubMed ID | 30675282 |
DOI | 10.3892/ol.2018.9853 |
Web of Science KeyUT | 000459551800096 |
Related Url | isVersionOf https://doi.org/10.3892/ol.2018.9853 |
FullText URL | BreastCancer_24_4_593.pdf BreastCancer_24_4_593_tbl_fig.pdf |
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Author | Saiga, Miho| Taira, Naruto| Kimata, Yoshihiro| Watanabe, Satoko| Mukai, Yuko| Shimozuma, Kojiro| Mizoo, Taeko| Nogami, Tomohiro| Iwamoto, Takayuki| Motoki, Takayuki| Shien, Tadahiko| Matsuoka, Junji| Doihara, Hiroyoshi| |
Keywords | BREAST-Q Breast cancer Breast reconstruction Health-related quality of life Satisfaction |
Published Date | 2017-03 |
Publication Title | Breast Cancer |
Volume | volume24 |
Issue | issue2 |
Publisher | Japanese Breast Cancer Society |
Start Page | 288 |
End Page | 298 |
ISSN | 1340-6868 |
NCID | AA1103354X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
File Version | author |
PubMed ID | 27179527 |
DOI | 10.1007/s12282-016-0703-6 |
Web of Science KeyUT | 000395524900012 |
Related Url | isVerionOf https://doi.org/10.1007/s12282-016-0703-6 |
JaLCDOI | 10.18926/AMO/54607 |
---|---|
FullText URL | 70_5_425.pdf |
Author | Tamura, Tomoki| Hirata, Taizo| Tabata, Masahiro| Hinotsu, Shiro| Hamada, Akinobu| Motoki, Takayuki| Iwamoto, Takayuki| Mizoo, Taeko| Nogami, Tomohiro| Shien, Tadahiko| Taira, Naruto| Matsuoka, Junji| Doihara, Hiroyoshi| |
Abstract | Docetaxel is a standard treatment for patients with advanced or recurrent breast cancer. The recommended dose is 60 to 100 mg/m2. Previous study have shown that the tumor response rates of patients who received docetaxel monotherapy at doses of 60, 75, and 100 mg/m2 were 22.1% , 23.3% , and 36.0% , respectively, and there was a significant relationship between the dose and response. In Europe and the United States, docetaxel is approved at a dose of 100 mg/m2, and Japanese guidelines also recommend a dose of 100 mg/m2. However, the approved dose in Japan is up to 75 mg/m2. We have launched a phase I trial evaluating 100 mg/m2 docetaxel in patients with advanced or relapsed breast cancer. The major eligibility criteria are as follows: age ≥20 years, pathologically diagnosed breast cancer, recurrent or advanced breast cancer, a good performance status, and HER2 [human epidermal growth factor receptor 2] negative. The primary endpoint is demonstrated safety of 100 mg/m2 docetaxel. This study will clarify whether 100mg/m2 docetaxel can be administrated safely in Japanese patients with advanced or recurrent breast cancer. |
Keywords | breast cancer phase I trial docetaxel |
Amo Type | Clinical Study Protocols |
Publication Title | Acta Medica Okayama |
Published Date | 2016-10 |
Volume | volume70 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 425 |
End Page | 427 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 27777441 |
Web of Science KeyUT | 000388098700018 |
JaLCDOI | 10.18926/AMO/54514 |
---|---|
FullText URL | 70_4_327.pdf |
Author | Watanabe, Mototsugu| Yamamoto, Hiromasa| Eikawa, Shingo| Shien, Kazuhiko| Shien, Tadahiko| Soh, Junichi| Hotta, Katsuyuki| Wada, Jun| Hinotsu, Shiro| Fujiwara, Toshiyoshi| Kiura, Katsuyuki| Doihara, Hiroyoshi| Miyoshi, Shinichiro| Udono, Heiichiro| Toyooka, Shinichi| |
Abstract | A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8+ T cells, which produce multiple cytokines. |
Keywords | metformin CD8+ T cells cancer immunology |
Amo Type | Clinical Study Protocols |
Publication Title | Acta Medica Okayama |
Published Date | 2016-08 |
Volume | volume70 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 327 |
End Page | 330 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 27549683 |
Web of Science KeyUT | 000384748600018 |