ID | 48264 |
JaLCDOI | |
FullText URL | |
Author |
Watanabe, Makiko
Ueno, Hiroshi
Suemitsu, Shunsuke
Yokobayashi, Eriko
Matsumoto, Yosuke
publons
researchmap
Sujiura, Hiroko
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Abstract | Recent studies have demonstrated the important role of immune molecules in the development of neuronal
circuitry and synaptic plasticity. We have detected the presence of FcγRllB protein in parvalbumin-
containing inhibitory interneurons (PV neurons). In the present study, we examined the appearance
of PV neurons in the barrel cortex and the effect of sensory deprivation in FcγRllB-deficient mice (FcγRllB-/-) and wild-type mice. There was no substantial difference in the appearance of PV neurons
in the developing barrel cortex between FcγRllB-/- and wild-type mice. Sensory deprivation from immediately after birth (P0) or P7 to P12-P14 induced an increase in PV neurons. In contrast, sensory deprivation from P7 or P14 to P28, but not from P21 to P28, decreased PV neurons in wild-type mice. However, sensory deprivation from P0 or P7 to P12-P14 did not increase PV neurons and sensory deprivation from P7 or P14 to P28 did not decrease or only modestly decreased PV neurons in FcγRllB-/- mice. The results indicate that expression of PV is regulated by sensory experience and the second and third postnatal weeks are a sensitive period for sensory deprivation, and suggest that FcγRllB contributes to sensory experience-regulated expression of PV.
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Keywords | parvalbumin
fast-spiking interneurons
FcγRllB
barrel cortex
sensory deprivation
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Amo Type | Original Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2012-04
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Volume | volume66
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Issue | issue2
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Publisher | Okayama University Medical School
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Start Page | 143
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End Page | 154
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |