JaLCDOI | 10.18926/AMO/30513 |
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FullText URL | fulltext.pdf |
Author | Takagaki, Masami| Hisamochi, Kunikazu| Morimoto, Toru| Bando, Ko| Sano, Shunji| Shimizu, Nobuyoshi| |
Abstract | A shortage of donor organs in clinical transplantation prompted us to study whether resuscitated dead hearts could be utilized for successful orthotopic heart transplantation. After 60 min of hypoxic cardiac arrest, one group of canine hearts was resuscitated (Res group, n = 6). The other group was harvested directly (Non-Res group, n = 6). In the Res group, cardiopulmonary bypass was utilized for resuscitation at 37 degrees C and the animals were then core-cooled to 15 degrees C. The hearts then were preserved in University of Wisconsin solution and orthotopically transplanted. Stable prostacyclin analogue (OP2507) and verapamil, a calcium antagonist, were added to the cardioplegia, and substrate-enriched warm blood cardioplegia and a hydroxy radical scavenger (EPC) were administered at the time of reperfusion of the transplanted heart. All animals in each group were successfully weaned from cardiopulmonary bypass with dopamine (5 micrograms/kg/min). Cardiac function without dopamine was better preserved in the Res group than the Non-Res group (Emax: 130.6 +/- 41.5% vs. 47.1 +/- 24.7%; mean +/- SD, as percent of postbrain death values, P < 0.01 by unpaired t-test). Cadaver hearts 60 min after anoxic arrest can be successfully re-animated and orthotopically engrafted. In addition, the core-cooling technique is useful. We believe this study serves as the key step in the clinical application of dead hearts to successful cardiac transplantation. |
Keywords | heart transplantation cadaver heart corecooling Emax |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1996-02 |
Volume | volume50 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 17 |
End Page | 24 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 8701777 |
Web of Science KeyUT | A1996TY06000003 |
JaLCDOI | 10.18926/AMO/30550 |
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FullText URL | fulltext.pdf |
Author | Shigenobu, Masaharu| Suzuki, Yoshihide| Sato, Junichi| Sadakane, Shoji| Maeda, Naotoshi| Sano, Shunji| Yamamoto, Mitsuo| Kurahara, Hideki| Teramoto, Shigeru| |
Abstract | In the aortic stenosis group, the left ventricular (LV) muscle mass index was a good parameter for predicting the prognosis. Associated mitral valve disease had no influence on long term survival after aortic valve replacement. In the aortic insufficiency group, associated mitral valve disease had a marked influence on the results of aortic valve replacement. In general, the aortic insufficiency group had less clinical improvement postoperatively than the aortic stenosis group. In the annuloaortic ectasia group, left ventricular enddiastolic pressure (LVEDP) might be the predictor to the prognosis. This group had the worst prognosis, of the three groups. Early operation should be considered for patients who have no, or only mild symptoms of, aortic valve disease. |
Keywords | aortic valve replacement late survival predictor aoetic stenosis aortic insufficiency annuloaortic ectasia. |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1980-06 |
Volume | volume34 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 189 |
End Page | 196 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 6447987 |
Web of Science KeyUT | A1980KE59200006 |
JaLCDOI | 10.18926/AMO/30734 |
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FullText URL | fulltext.pdf |
Author | Sugimoto, Seiichiro| Doihara, Hiroyoshi| Ogasawara, Yutaka| Aoe, Motoi| Sano, Shunji| Shimizu, Nobuyoshi| |
Abstract | A 61-year-old man, who was diagnosed with superior vena cava syndrome by papillary thyroid carcinoma, was referred to our hospital. A bulky thyroid tumor with tracheal invasion extended from the left neck to the right atrium without distant metastases. The risk of sudden death due to airway occlusion, tumor embolism or obstruction of the tricuspid valve led us to elect surgery. Extended resection of thyroid cancer was performed with cardiopulmonary bypass. Peritoneal dissemination was found via laparotomy. A histological diagnosis of anaplastic carcinoma arising from transformation of papillary carcinoma was made. After the operation, bilateral ureteral occlusion by peritoneal dissemination and multiple lung metastases were detected. The patient died with acute renal failure on postoperative day 12. Intraatrial extension of thyroid cancer is rare, and only 12 cases have been reported in the literature. We present a case of thyroid cancer with intraatrial extension. |
Keywords | superior vena cava syndrome thyroid cancer cardiopulmonary bypass |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2006-04 |
Volume | volume60 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 135 |
End Page | 140 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 16680191 |
Web of Science KeyUT | 000237001900010 |
JaLCDOI | 10.18926/AMO/30777 |
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FullText URL | fulltext.pdf |
Author | Nakamura, Koki| Irie, Hiroyuki| Sano, Shunji| |
Abstract | Even after successful operations, ugly postoperative skin scars are often distressing to patients and their parents. To judge the success of surgical methods and postoperative treatment, postoperative scars should be evaluated using a quantitative system. Height and width are easily measured, but scar redness is not. We have developed a simple and effective method for evaluating scar redness. According to the color definitions employed in computer graphics, each color can be expressed as RGB (red, green or blue) coordinates (r, g, b): 0 ≦ r, g, b ≦ 10. The degree of scar redness is defined by the following formula: redness score (RS) = (r1 - r0)2 + (g1 - g0)2 + (b1 - b0)2. Here, (R1, g1, b1) = coordinates of the scar color and (r0, g0, b0) = coordinates of the surrounding skin color. RS was evaluated in 59 children (35 males, 24 females; ages 1 month to 12 years old) who had scar redness after congenital cardiac surgery. For each patient, scar color and surrounding skin color was identified on the color sample table. Scar redness was also evaluated by the conventional grading method: 1 = mild, 2 = moderate and 3 = severe. The RS of the colored scars ranged from 4 to 100 (38 ± 27). By the conventional grading method, 44 scars were grade 1, 15 grade 2 and none grade 3. RS was significantly higher among grade 2 than grade 1 patients, 52 ± 25 and 33 ± 27, respectively (P < 0.05). Given its subjectivity, the conventional grading method yields variable data; surrounding skin color, moreover, is not considered. Our new evaluation method using RS effectively and accurately defines scar and skin colors, and allows quantitative studies of these factors. |
Keywords | redness score scar redness quantification evaluation |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1997-04 |
Volume | volume51 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 101 |
End Page | 104 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 9142347 |
Web of Science KeyUT | A1997WX19600007 |
JaLCDOI | 10.18926/AMO/30856 |
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FullText URL | fulltext.pdf |
Author | Sano, shunji| Nawa, Sugato| Senoo, Yoshimasa| Teramoto, Shigeru| |
Abstract | Dynamic ergometer exercise in a supine position was applied to 64 patients more than 1 year after valvular heart surgery, and the left ventricular reserve was evaluated echocardiographically. The left ventricular reserve declined in the mitral stenosis-mitral valve replacement group, while it was better maintained in the mitral stenosis-mitral commissurotomy, aortic regurgitation and aortic stenosis groups. The patients were divided into 3 groups depending on whether the percentage increase during exercise of stroke index, an index of left ventricular pump function, increased, unchanged, or decreased. The percentage increase of mean velocity of circumferential fibre shortening (y) and that of left ventricular end-diastolic diameter (x) during exercise were plotted for each group. The increased group was isolated from the unchanged group by the line of y = -5.02x + 30.1; the unchanged group was isolated from the decreased group by that of y = -5.68x-10.0, and the increased and unchanged groups were clearly isolated from the decreased group by that of y = -6.86x-4.76. We conclude that dynamic ergometer exercise echocardiography is useful for evaluating the left ventricular reserve of postoperative patients with valvular heart disease. It was also thought that the subclinical state of cardiac failure can be effectively detected by the present method.</P> |
Keywords | left ventricular reserve dynamic exercise echocardiography valvular heart disease ergometer |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1989-08 |
Volume | volume43 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 223 |
End Page | 231 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 2801186 |
Web of Science KeyUT | A1989AP79100004 |
JaLCDOI | 10.18926/AMO/30884 |
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FullText URL | fulltext.pdf |
Author | Sano, Shunji| Yokota, Yoshio| Makino, Seiichiro| |
Abstract | Seventeen patients having extracardiac valved conduits placed between the right ventricle and pulmonary artery were followed for 7 to 87 months postoperatively (mean, 42 months), at the Heart Institute, Kenritsu Amagasaki Hospital, Japan. There were no late deaths in the study group. Three conduits have been replaced, all because of conduit stenosis. In two-dimensional echocardiographic examinations, commissural fusion and calcification of the valve were noted in 6 out of 16 xenograft valved conduits. Mechanical valve immobility was found in one patient. Neointimal peel of the dacron graft was noted in 6 out of 17 cases, and marked left ventricular deformity in the short axis view was found in 6. Late cardiac catheterization was done in 6 patients who were suspected of having valve failure and right ventricular hypertension by two-dimensional echocardiography. All 6 of these patients showed a high pressure gradient between the pulmonary artery and right ventricle and also had elevated right ventricular pressure. In conclusion, two-dimensional echocardiography is a simple, non-invasive and very accurate method for detecting conduit stenosis and valve failure. An echocardiographic series should be performed for a long-time postoperatively because obstructions of valved conduits may be progressive, and an operation may be advisable in order to prevent the development of advanced right ventricular hypertrophy and deterioration. |
Keywords | extracardiac valved conduit conduit stenosis two-demensional echocardiography |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1989-06 |
Volume | volume43 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 175 |
End Page | 184 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 2763867 |
Web of Science KeyUT | A1989AG01600006 |
JaLCDOI | 10.18926/AMO/31313 |
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FullText URL | fulltext.pdf |
Author | Fujii, Yoichi| Sugawara, Eiji| Hayashi, Kazuhiko| Sano, Shunji| |
Abstract | Intrathymic (i.t.) injection of allogenic cells without administration of anti-lymphocyte serum (ALS) in neonatal recipients has induced donor-specific tolerance to subsequent cardiac allografts in rats. This study examines whether similar tactics can be successfully applied to a hamster-to-rat cardiac xenotransplantation model. Lewis neonates on their first day of life underwent i.t., subcutaneous (s.c.), intraperitoneal (i.p.), or intravenous (i.v.) injections of 5 x 10(7) Golden Syrian hamster splenocytes. After six weeks, the rats underwent heterotopic cardiac transplantation of hamster hearts. Cyclophosphamide (CyP) was administered on the day before surgery and postoperatively to suppress antibody-mediated graft rejection. Rats given splenocytes with 80 mg/kg of CyP had the following graft survival times: 8 to 12 days for i.t. injection (mean, 9.4 days); 5 to 7 days for s.c. injection (mean, 6.6 days); 4 to 11 days for i.p. injection (mean, 7.4 days); and 4 to 13 days for i.v. injection (mean, 7.9 days). Only the extension of graft survival produced by i.t. injection was statistically significant in comparison with the rats given only CyP treatment (mean, 7.5 days; P < 0.05). Thus, it appears that i.t. injection of xenogenic splenocytes in neonatal recipients with administration of CyP, but without ALS, can prolong xenograft survival. This biological intervention may be most useful in pediatric xenotransplantation when combined with other immunomodulation techniques. |
Keywords | intrathymic injection neonatal tolerance xenografts |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1998-04 |
Volume | volume52 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 83 |
End Page | 88 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 9588223 |
Web of Science KeyUT | 000073363000003 |
JaLCDOI | 10.18926/AMO/31314 |
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FullText URL | fulltext.pdf |
Author | Yunoki, Keiji| Uchida, Hatuzo| Sano, Shunji| Shimizu, Nobuyoshi| |
Abstract | Acute aortic dissection is a life-threatening condition, and may be treated with aggressive hypotensive drug therapy, but emergency surgery is often necessary. We evaluated the effectiveness of stent-grafts for the treatment of acute aortic dissection. Aortic dissection was surgically created in the descending thoracic aorta in 20 adult mongrel dogs. A stent-graft was inserted in the entry position. The tested animals were divided into 4 groups based on re-entry type and blood pressure alteration rate (AR) after acute aortic dissection. After insertion of the stent, the following results were observed: a) AR improved; b) proximal descending aorta and superior mesenteric arterial flows increased; c) cardiac function improved; and d) the dissecting aortic diameter decreased in the presence of pressure gradient group. From these results, insertion of a stent-graft to treat acute aortic dissection was judged to be effective. |
Keywords | stent-graft endoluminal graft acute aortic dissection Blanton’s methed |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1998-04 |
Volume | volume52 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 89 |
End Page | 95 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 9588224 |
Web of Science KeyUT | 000073363000004 |
Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/6434 |
JaLCDOI | 10.18926/AMO/31757 |
---|---|
FullText URL | fulltext.pdf |
Author | Sano, Shunji| Nawa, Sugato| Senoo, Yoshimasa| Teramoto, Shigeru| |
Abstract | Thirty-eight patients were operated on for mitral stenosis between March 1979 and September 1981. Thirty-six of them were examined as to their age, symptom duration, chest roentgenograms, electrocardiograms and echocardiograms to obtain various indices of left ventricular function. The usefulness of these indices as preoperative risk factors for predicting postoperative low cardiac output syndrome (LOS) was investigated. Cases which had values of ejection fraction, cardiac index, percent fiber shortening or mean velocity of circumferential fiber shortening less than 0.45, 2.0 l/min/m2, 25% and 0.80 circ/sec, respectively, in the preoperative echocardiographic examination were associated with a greater chance of postoperative LOS. Each of these factors was independently useful as a risk factor in cardiac surgery for mitral stenosis. Moreover, it was revealed that the combination of a preoperative percent fractional shortening (%FS) of less than 30% and a cardiac index smaller than 2.0 l/min/m2 indicated a strong predisposition toward postoperative LOS. |
Keywords | mitral stenosis low cardiac output syndrome risk factor echocardiography |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1987-10 |
Volume | volume41 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 215 |
End Page | 222 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 3687493 |
Web of Science KeyUT | A1987K590100005 |
JaLCDOI | 10.18926/AMO/31832 |
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FullText URL | fulltext.pdf |
Author | Itoh, Atsushi| Tomita, Hideshi| Sano, Shunji| |
Abstract | Little information is available on the mechanism of diastolic left ventricular (LV) dysfunction in patients with chronic respiratory disease complicated by hypoxia. The purpose of this study was to investigate how chronic hypoxia impairs LV diastolic function in an hypoxic animal model. Thirty-six male Wistar rats 8 weeks old were assigned to normoxia (N), chronic hypoxia (CH), and re-normoxia (RN) groups, 12 rats per group. The N group rats were kept in ambient air for 8 weeks, while the CH group was kept hypoxic for 8 weeks. After 8 weeks of hypoxia the RN group rats were kept for a further 8 weeks in ambient air. LV systolic and diastolic functions, as well as right ventricular (RV) function, were analyzed using Doppler echocardiography;we also measured the hematocrit, and weighed the LV and RV. Hematocrit, RV weight/body weight, and RV weight/LV weight were higher in the CH group than in the other 2 groups. However, most of these parameters returned to normoxia levels after re-normoxia. In the CH group, LV dimension and area were smaller than in the other 2 groups. LV systolic function was preserved in all groups;however, in the CH group, mitral flow showed a restrictive pattern, while pulmonary flow demonstrated a pulmonary hypertensive pattern with prolonged RV ejection time. In conclusion, chronic hypoxia induced pulmonary hypertension and RV hypertrophy. Although LV systolic function was preserved, diastolic function was impaired in hypoxia. Ventricular interaction may impair LV diastolic function. |
Keywords | chronic hypoxia left ventricular diastolic function pulmonary hypertension right ventricular hypertrophy ventricular interaction |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2009-04 |
Volume | volume63 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 87 |
End Page | 96 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 19404340 |
Web of Science KeyUT | 000265457600003 |
JaLCDOI | 10.18926/AMO/31840 |
---|---|
FullText URL | fulltext.pdf |
Author | Fujita, Yasufumi| Ishino, Kozo| Nakanishi, Koji| Fujii, Yasuhiro| Kawada, Masaaki| Sano, Shunji| |
Abstract | This study evaluated the effects of chronic hypoxia from birth on the resistance of rat hearts to global ischemia, with special emphasis on the duration of hypoxia. Male Wistar rats were housed from birth for 4 weeks or 8 weeks either in a hypoxic environment (FiO20.12) or in ambient air (8 animals for each group). Isolated rat hearts were perfused for 40 min with oxygenated Krebs-Henseleit buffer, subjected to 20 min global no-flow ischemia at 37, and then underwent 40 min of reperfusion. A non-elastic balloon was inserted into the left ventricle and inflated until the pre-ischemic LVEDP rose to 8mmHg. Cardiac function was measured before and after ischemia. The post-ischemic percent recovery of LVDP in hypoxic hearts was worse than in normoxic hearts (4 weeks:55+/-7 vs. 96+/-3%, p0.01;8 weeks:40+/-5 vs. 92+/-4%, p0.01), and was worst in the 8-week-hypoxic hearts. Similarly, the percent recovery of dP/dt in the hypoxic hearts was lower than in the normoxic hearts (4 weeks:51+/-5 vs. 96+/-7%, p0.01;8 weeks:31+/-6 vs. 92+/-7%, p0.01), and was lowest in the 8-week-hypoxic hearts. In conclusion, cyanotic myocardium revealed an age-dependent vulnerability to ischemia-reperfusion injury in a chronic hypoxic rat model. |
Keywords | chronic hypoxia ischemia-reperfusion injury aging |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2009-10 |
Volume | volume63 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 237 |
End Page | 242 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 19893599 |
Web of Science KeyUT | 000271132000003 |
JaLCDOI | 10.18926/AMO/31981 |
---|---|
FullText URL | fulltext.pdf |
Author | Ohtsuki, Shinnichi| Baba, Kenji| Kataoka, Kohichi| Ohno, Naoki| Okamoto, Yoshio| Ishino, Kozo| Kawada, Masaaki| Sano, Shunji| Sato, Shuhei| Morishima, Tsuneo| |
Abstract | We investigated the usefulness of helical computed tomography(CT)in the morphological diagnosis of pulmonary vein stenosis, particularly that in infants and small children. In total, 20 helical CT examinations were performed in 10 post-operative cases of Total Anomalous Pulmonary Venous Drainage(TAPVD), 3 cases of single right ventricle, and 1 case of single left ventricle. In all cases, distinct morphological imaging was possible. Pulmonary vein stenosis could be categorized into three types: (1)stenosis from the anastomosis of the common pulmonary vein (CPV)-the left atrium (LA) to the peripheral pulmonary vein; (2) stenosis only at the anastomosis of CPV-LA; and (3) stenosis due to compression by nearby organs. Coronal views by multiplanar reconstruction (MPR) provided morphological information along the up-down direction of the body axis. Morphological diagnosis of pulmonary vein stenosis is important in deciding prognosis and therapeutic regimens, and helical CT was considered useful for such diagnosis in our 14 young patients. |
Keywords | pulmonary vein stenosis helical CT |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2005-06 |
Volume | volume59 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 93 |
End Page | 98 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 16049562 |
Web of Science KeyUT | 000230039100004 |
JaLCDOI | 10.18926/AMO/32016 |
---|---|
FullText URL | fulltext.pdf |
Author | Yasui, Kotaro| Kanazawa, Susumu| Mimura, Hidefumi| Dendo, Shuichi| Hiraki, Yoshio| Irie, Hiroyuki| Sano, Shunji| |
Abstract | An 83-year-old man with a large internal iliac artery aneurysm (IIAA) was treated with the use of stent-graft, suggesting successful results at 3, 6, and 12 months after treatment. However, 24-month follow-up computed tomography showed minor peripheral opacification of the IIAA. The patient underwent surgical endoaneurysmorrhaphy. No previous report of long-term recanalization of a satisfactorily thrombosed iliac artery aneurysm at 2 years or more after stent-grafting has been previously reported. Further follow-up studies need to be performed on the present procedure before anyone can confidently recommend it in regard to its long-term safety. |
Keywords | aneurysm iliac---stents and prosthesis |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2001-11 |
Volume | volume55 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 315 |
End Page | 318 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 11688956 |
Web of Science KeyUT | 000171635400009 |
JaLCDOI | 10.18926/AMO/32300 |
---|---|
FullText URL | fulltext.pdf |
Author | Nakamura, Koki| Irie, Hiroyuki| Fujisawa, Emi| Yoshioka, Hidekatsu| Ninomiya, Yoshifumi| Sakuma, Isao| Sano, Shunji| |
Abstract | While heat shock protein (HSP) 72 is known as a stress protein, there have been no reports of HSP 72 expression in patients who have undergone surgery for congenital heart disease. Fourteen patients (7 males and 7 females) who had undergone surgery for congenital heart disease were studied. The ages of the patients ranged from 2 months to 43 years old (mean 6.5 +/- 10.8 years old; median 3.0 years old). The diagnoses were Tetralogy of Fallot in seven, pulmonary atresia with ventricular septal defect (VSD) in three, complex anomalies in three, and VSD in one patient. Histological study and HSP analysis using Western blots and immunostaining with anti-HSP 72 monoclonal antibody were performed for right ventricular muscle samples resected during the surgery. The histological findings showed hypertrophic changes of ventricular cardiomyocytes in all samples studied. Western blots detected HSP 72 expression of various degrees in all specimens. Immunostaining using monoclonal antibody against HSP 72 showed that the protein was present in the nuclei and cytoplasm of cardiomyocytes. In conclusion, although it is difficult to determine the cause of the "stress" that triggers HSP 72 expression in cardiomyocytes, low O2 saturation and pressure overload might act as a "stress", and the only common factor that induced HSP 72 in every sample was hypertrophy. |
Keywords | heat shock protein 72 (HSP 72) human heart congentional cardiac surgery hypertrophy |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2000-06 |
Volume | volume54 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 103 |
End Page | 109 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 10925734 |
Web of Science KeyUT | 000087965700002 |
JaLCDOI | 10.18926/AMO/32846 |
---|---|
FullText URL | fulltext.pdf |
Author | Mine, Yoshinari| Mitsui, Hideya| Oshima, Yu| Noishiki, Yasuharu| Nakai, Mikizo| Sano, Shunji| |
Abstract | Our meticulous investigation of ePTFE graft breakage when a wire placed at the edge of an ePTFE graft was pulled, revealed that, depending on the breakage pattern, a break starts much earlier than the peak suture retention strength, which is the current international indicator for anastomotic-site break strength. Furthermore, the breakage patterns differ based on the thickness of the wire and the fiber direction of the ePTFE graft. Based on these findings, we advocate measuring the peak suture retention strength using 0.10-mm sutures and a standardized wire thickness in order to assess the anastomotic retention strength of ePTFE grafts. |
Keywords | ePTFE suture retention strength anastomotic strength |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2010-04 |
Volume | volume64 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 121 |
End Page | 128 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 20424667 |
Web of Science KeyUT | 000276996900006 |
JaLCDOI | 10.18926/AMO/32908 |
---|---|
FullText URL | fulltext.pdf |
Author | Fujii, Yasuhiro| Kasahara, Shingo| Kanki,, Kazushige| Mitsui, Hideya| Ishino, Kozo| Sano, Shunji| |
Abstract | We describe a successful case of surgical treatment for anomalous left coronary artery from the pulmonary artery (ALCAPA) syndrome with severe left ventricular dysfunction. Because of the severe left ventricular dysfunction, we planned to use an extracorporeal membrane oxygenation for heart support until a satisfactory recovery had been established. The left ventricular function signifi cantly recovered in a few days, and the patient could be discharged without any complications. |
Keywords | coronary circulation anomalous left coronary artery from the pulmonary artery extracorporeal circulation extracorporeal membrane oxygenation |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2007-02 |
Volume | volume61 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 41 |
End Page | 45 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 17332841 |
Web of Science KeyUT | 000244432400006 |
JaLCDOI | 10.18926/AMO/41325 |
---|---|
FullText URL | 64_6_391.pdf |
Author | Suezawa, Takanori| Ishino, Kozo| Honjo, Osami| Osaki, Satoru| Kotani, Yasuhiro| Sano, Shunji| |
Abstract | We developed a new cardiopulmonary bypass (CPB) method to minimize myocardial damage during aortic arch reconstruction. In this method, coronary flow and heartbeat were stabilized by maintaining the aortic root pressure with an adjusted preload of the ventricle during aortic cross-clamping. This study was performed to determine the appropriate root pressure to maintain the heartbeat without causing deterioration of ventricular function. Study 1. Under partial CPB, the ascending aorta was cross-clamped in 6 pigs (group 1). Experimental data at various systolic aortic root pressures was analysed to determine the appropriate root pressure. Study 2. In group 2 (control, n=6), the aorta was not clamped, while in group 3 (n=6), the aorta was cross-clamped for 60 min and the systolic aortic root pressure was maintained at the pressure determined in study 1. Study 1. The diastolic coronary flow was stabilized at values comparable to that before initiation of CPB (6.6±1.4ml/beat) when the systolic aortic root pressure was above 80mmHg. Intracardiac pressure and the myocardial oxygen consumption (MvO2) seemed to be acceptable when the systolic aortic root pressure was below 100mmHg. Therefore, 90mmHg was selected for study 2. Study 2. Perioperative cardiac function did not differ between the groups. We concluded that 90mmHg was the systolic aortic root pressure appropriate for this method. |
Keywords | aortic cross-clamp coronary flow root pressure cardiopulmonary bypass arch repair |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2010-12 |
Volume | volume64 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 391 |
End Page | 397 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 21173809 |
Web of Science KeyUT | 000285664200006 |
Author | 佐野 俊二| |
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Published Date | 1982-09-30 |
Publication Title | |
Content Type | Thesis or Dissertation |
Author | 佐野 俊二| |
---|---|
Published Date | 2008-08-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume120 |
Issue | issue2 |
Content Type | Journal Article |
Author | 佐野 俊二| |
---|---|
Published Date | 2001-12-31 |
Publication Title | 岡山医学会雑誌 |
Volume | volume113 |
Issue | issue3 |
Content Type | Others |