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ID 61151
Author
Oti, Takumi Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Satoh, Keita Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Uta, Daisuke Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
Nagafuchi, Junta Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Tateishi, Sayaka Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Ueda, Ryota Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Takanami, Keiko Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Young, Larry J. Center for Translational Social Neuroscience, Silvio O. Conte Center for Oxytocin and Social Cognition, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University
Galione, Antony Department of Pharmacology, University of Oxford
Morris, John F. Department of Physiology, Anatomy & Genetics, University of Oxford
Sakamoto, Tatsuya Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Sakamoto, Hirotaka Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University ORCID Kaken ID publons researchmap
Abstract
Oxytocinergic neurons in the paraventricular nucleus of the hypothalamus that project to extrahypothalamic brain areas and the lumbar spinal cord play an important role in the control of erectile function and male sexual behavior in mammals. The gastrin-releasing peptide (GRP) system in the lumbosacral spinal cord is an important component of the neural circuits that control penile reflexes in rats, circuits that are commonly referred to as the “spinal ejaculation generator (SEG).” We have examined the functional interaction between the SEG neurons and the hypothalamo-spinal oxytocin system in rats. Here, we show that SEG/GRP neurons express oxytocin receptors and are activated by oxytocin during male sexual behavior. Intrathecal injection of oxytocin receptor antagonist not only attenuates ejaculation but also affects pre-ejaculatory behavior during normal sexual activity. Electron microscopy of potassium-stimulated acute slices of the lumbar cord showed that oxytocin-neurophysin-immunoreactivity was detected in large numbers of neurosecretory dense-cored vesicles, many of which are located close to the plasmalemma of axonal varicosities in which no electron-lucent microvesicles or synaptic membrane thickenings were visible. These results suggested that, in rats, release of oxytocin in the lumbar spinal cord is not limited to conventional synapses but occurs by exocytosis of the dense-cored vesicles from axonal varicosities and acts by diffusion—a localized volume transmission—to reach oxytocin receptors on GRP neurons and facilitate male sexual function.
Keywords
oxytocin
localized volume transmission
spinal cord
male sexual activity
gastrin-releasing peptide
spinal ejaculation generator
Note
This fulltext is available in Oct. 2021.
Published Date
2020-10-29
Publication Title
Current Biology
Volume
volume31
Issue
issue1
Publisher
Elsevier
Start Page
103
End Page
114.e5
ISSN
0960-9822
NCID
AA1081652X
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
PubMed ID
DOI
Related Url
isVersionOf https://doi.org/10.1016/j.cub.2020.09.089
License
https://creativecommons.org/licenses/by-nc-nd/4.0/