Elsevier Science BV.Acta Medica Okayama0920-5861164120112-Diphenylphosphanyl-4-pyridyl(dimethyl) amine as an effective ligand for the ruthenium(II) complex catalyzed homogeneous hydration of nitriles under neutral conditions552555ENMakotoMuranakaIsaoHyodoWataruOkumuraToshiyukiOshikiNew homogeneous catalyst comprised of [Ru(methallyl)(2)(cod)] (cod = 1,5-cyclooctadiene) (1) and 2-diphenylphosphanyl-4-pyridyl(dimethyl) amine (2) is shown to efficiently catalyze the hydration of various nitriles under neutral conditions. The hydration proceeds in the presence of 0.5 mol% of the ruthenium catalyst at 80 degrees C in 1,2-dimethoxyethane solution and the corresponding amide is obtained within few hours without the formation of by products. Comparison of some phosphine ligands for the hydration reveals that the dimethylamino moiety of 2 improves the catalytic performance dramatically.No potential conflict of interest relevant to this article was reported.Okayama University Medical SchoolActa Medica Okayama0386-300X7442020Cytotoxic Effects of Alcohol Extracts from a Plastic Wrap (Polyvinylidene Chloride) on Human Cultured Liver Cells and Mouse Primary Cultured Liver Cells327334ENKen-ichiYamamotoDepartment of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesHirokoKagawaOkayama University HospitalSakaeArimotoDivision of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesXian WenTanDepartment of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesKentoYasuiDepartment of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesToshiyukiOshikiDepartment of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama UniversityMasakiyoSakaguchiDepartment of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesOriginal Article10.18926/AMO/60371An increasing accumulation of microplastics and further degraded nanoplastics in our environment is suspected to have harmful effects on humans and animals. To clarify this problem, we tested the cytotoxicity of two types of plastic wrap on human cultured liver cells and mouse primary cultured liver cells. Alcohol extracts from plastic wrap, i.e., polyvinylidene chloride (PVDC), showed cytotoxic effects on the cells. Alcohol extracts of polyethylene (PE) wrap were not toxic. The commercially available PVDC wrap consists of vinylidene chloride, epoxidized soybean oil, epoxidized linseed oil as a stiffener and stabilizer; we sought to identify which component(s) are toxic. The epoxidized soybean oil and epoxidized linseed oil exerted strong cytotoxicity, but the plastic raw material itself, vinylidene chloride, did not. Our findings indicate that plastic wraps should be used with caution in order to prevent health risks.No potential conflict of interest relevant to this article was reported.Acta Medica OkayamaToward Industrial Applications of Homogeneous CatalystsENToshiyukiOshikiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2007タンタル上のアルキン配位子交換反応の機構研究ENToshiyukiOshiki研究内容
シリルアルキン錯体の合成とその反応性。
アルキン交換反応の速度式と活性化パラメータの算出。
アルキン交換反応の新規錯体合成への応用。No potential conflict of interest relevant to this article was reported.化学工業日報社Acta Medica Okayama0453-06835822011問われる産と学の決断と勇気5055ENToshiyukiOshikiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama地域の産学連携による省エネ型次世代触媒技術の開発ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama有機エレクトロニクス材料の中規模製造工程の開発ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2007水-有機多相系を制御する新規錯体触媒プロセスによるシンプル水和
反応の開発ENToshiyukiOshiki極性官能基をもつニトリルやエステルを錯体触媒により水和(加水分解)し、工業的に重要なアミドや脂肪酸を得るための究極のシンプルな新規製造プロセスの開発が目的です。その実現のためには、水と油(有機化合物)の多相系を「科学的」及び「工学的」に制御することが必要です。本研究では、新たに開発する多相系制御技術を協奏的に活用し、化学産業で強く求められている環境調和の省エネルギー型水和プロセスの完成を目指します。No potential conflict of interest relevant to this article was reported.Acta Medica Okayama2007錯体触媒による革新的化学品製造技術の開発ENToshiyukiOshikiAkinoriIshiduka水和反応は原理的に副生成物が出ないため、本質的に環境への負荷が少ない反応です。この反応に適用できる高活性触媒を開発し、しかも溶媒なしでアミド製造が実現できたことは大きなイノベーションです。さらに、これを出発点として、他の化学品を省エネルギー型水和反応により製造する技術開発を民間企業との連携により現在進めています。岡山大学では、このような自然と人間の共生を目指した研究を通じて、我が国の産業技術開発を担う人材育成に取り組んでいます。No potential conflict of interest relevant to this article was reported.Acta Medica Okayama高濃度ギ酸から水素を製造する化学触媒法ENToshiyukiOshikiNo potential conflict of interest relevant to this article was reported.