Title Alternative | The 55th Annual Meeting of the Japanese Society for Matrix Biology and Medicine |
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Author | Oohashi, Toshitaka| |
Publication Title | Journal of Okayama Medical Association |
Published Date | 2023-12-01 |
Volume | volume135 |
Issue | issue3 |
Start Page | 174 |
End Page | 174 |
ISSN | 0030-1558 |
Related Url | isVersionOf https://doi.org/10.4044/joma.135.174 |
language | Japanese |
Copyright Holders | Copyright (c) 2023 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.135.174 |
FullText URL | fulltext.pdf |
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Author | Fujita, Hirofumi| Ando, Aoi| Mizusawa, Yohei| Ono, Mitsuaki| Hattori, Takako| Habuta, Munenori| Oohashi, Toshitaka| Kubota, Satoshi| Ohuchi, Hideyo| |
Published Date | 2022-11-17 |
Publication Title | Plos One |
Volume | volume17 |
Issue | issue11 |
Publisher | Public Library Science |
Start Page | e0277307 |
ISSN | 1932-6203 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2022 Fujita et al. |
File Version | publisher |
PubMed ID | 36395281 |
DOI | 10.1371/journal.pone.0277307 |
Web of Science KeyUT | 000926013600060 |
Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0277307 |
FullText URL | fulltext.pdf |
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Author | Tanaka, Yukie| Aung, Kyaw Thu| Ono, Mitsuaki| Mikai, Akihiro| Dang, Anh Tuan| Hara, Emilio Satoshi| Tosa, Ikue| Ishibashi, Kei| Ono-Kimura, Aya| Nawachi, Kumiko| Kuboki, Takuo| Oohashi, Toshitaka| |
Keywords | medication-related osteonecrosis of the jaw BMP-2 beta-tricalcium phosphate bone formation bone necrosis |
Published Date | 2021-11-26 |
Publication Title | International Journal Of Molecular Sciences |
Volume | volume22 |
Issue | issue23 |
Publisher | MDPI |
Start Page | 12823 |
ISSN | 1422-0067 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 by the authors. |
File Version | publisher |
PubMed ID | 34884630 |
DOI | 10.3390/ijms222312823 |
Web of Science KeyUT | 000735802700001 |
Related Url | isVersionOf https://doi.org/10.3390/ijms222312823 |
FullText URL | fulltext.pdf |
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Author | Nojima, Kojiro| Miyazaki, Haruko| Hori, Tetsuya| Vargova, Lydia| Oohashi, Toshitaka| |
Keywords | perineuronal net chondroitin sulfate proteoglycan calyx of Held hyaluronan and proteoglycan binding link protein 4 synapse in situ proximity ligation assay |
Published Date | 2021-09-17 |
Publication Title | Frontiers In Cell and Developmental Biology |
Volume | volume9 |
Publisher | Frontiers Media SA |
Start Page | 730550 |
ISSN | 2296-634X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 Nojima, Miyazaki, Hori, Vargova and Oohashi. |
File Version | publisher |
PubMed ID | 34604231 |
DOI | 10.3389/fcell.2021.730550 |
Web of Science KeyUT | 000702518100001 |
Related Url | isVersionOf https://doi.org/10.3389/fcell.2021.730550 |
FullText URL | fulltext.pdf |
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Author | Tang, Shaoying| Yonezawa, Tomoko| Maeda, Yukihide| Ono, Mitsuaki| Maeba, Takahiro| Miyoshi, Toru| Momota, Ryusuke| Tomono, Yasuko| Oohashi, Toshitaka| |
Published Date | 2021-04-13 |
Publication Title | PLoS ONE |
Volume | volume16 |
Issue | issue4 |
Publisher | Public Library Science |
Start Page | e0249909 |
ISSN | 1932-6203 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 Tang et al. |
File Version | publisher |
PubMed ID | 33848312 |
NAID | 120007042400 |
DOI | 10.1371/journal.pone.0249909 |
Web of Science KeyUT | 000640373500028 |
Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0249909 |
FullText URL | fulltext.pdf |
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Author | Nosho, Shuji| Tosa, Ikue| Ono, Mitsuaki| Hara, Emilio Satoshi| Ishibashi, Kei| Mikai, Akihiro| Tanaka, Yukie| Kimura-Ono, Aya| Komori, Taishi| Maekawa, Kenji| Kuboki, Takuo| Oohashi, Toshitaka| |
Keywords | BMP-2 FGF-2 bone formation bone marrow |
Published Date | 2020-10-27 |
Publication Title | International Journal of Molecular Sciences |
Volume | volume21 |
Issue | issue21 |
Publisher | MDPI |
Start Page | 7967 |
ISSN | 1422-0067 |
NCID | AA12038549 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 33120952 |
DOI | 10.3390/ijms21217967 |
Web of Science KeyUT | 000588995400001 |
Related Url | isVersionOf https://doi.org/10.3390/ijms21217967 |
FullText URL | fulltext.pdf |
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Author | Mikai, Akihiro| Ono, Mitsuaki| Tosa, Ikue| Ha Thi Thu, Nguyen| Hara, Emilio Satoshi| Nosho, Shuji| Kimura-Ono, Aya| Nawachi, Kumiko| Takarada, Takeshi| Kuboki, Takuo| Oohashi, Toshitaka| |
Keywords | BMP-2 MRONJ bone regeneration |
Published Date | 2020-09-24 |
Publication Title | International Journal of Molecular Sciences |
Volume | volume21 |
Issue | issue19 |
Publisher | MDPI |
Start Page | 7028 |
ISSN | 1422-0067 |
NCID | AA12038549 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 32987737 |
DOI | 10.3390/ijms21197028 |
Web of Science KeyUT | 000586659200001 |
Related Url | isVersionOf https://doi.org/10.3390/ijms21197028 |
FullText URL | fulltext.pdf |
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Author | Ohtsuki, Takashi| Shinaoka, Akira| Kumagishi-Shinaoka, Kanae| Asano, Keiichi| Hatipoglu, Omer Faruk| Inagaki, Junko| Takahashi, Ken| Oohashi, Toshitaka| Nishida, Keiichiro| Naruse, Keiji| Hirohata, Satoshi| |
Published Date | 2019-10-15 |
Publication Title | Experimental Cell Research |
Volume | volume383 |
Issue | issue2 |
Publisher | Elsevier |
Start Page | 111556 |
ISSN | 00144827 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 The Authors. Published by Elsevier Inc. |
File Version | publisher |
PubMed ID | 31415758 |
DOI | 10.1016/j.yexcr.2019.111556 |
Web of Science KeyUT | 000488145400017 |
Related Url | isVersionOf https://doi.org/10.1016/j.yexcr.2019.111556 |
Title Alternative | Role of COLXV/XVⅢ gene, Multiplexin, as a basement membrane toolkit |
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FullText URL | 127_103.pdf |
Author | Oohashi, Toshitaka| |
Keywords | 基底膜 ツールキット XV/XVⅢ型コラーゲン プロテオグリカン ミトコンドリア |
Publication Title | 岡山医学会雑誌 |
Published Date | 2015-08-03 |
Volume | volume127 |
Issue | issue2 |
Start Page | 103 |
End Page | 109 |
ISSN | 0030-1558 |
Related Url | isVersionOf https://doi.org/10.4044/joma.127.103 |
language | Japanese |
Copyright Holders | Copyright (c) 2015 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.127.103 |
NAID | 130005096251 |
JaLCDOI | 10.18926/AMO/53521 |
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FullText URL | 69_3_145.pdf |
Author | Ishii, Hiroko| Kamikawa, Shigeshi| Hirohata, Satoshi| Mizutani, Akifumi| Abe, Koji| Seno, Masaharu| Oohashi, Toshitaka| Ninomiya, Yoshifumi| |
Abstract | Eosinophil cationic protein (ECP) is well known as a cationic protein contained in the basic granules of activated eosinophils. Recent studies have reported that ECP exhibits novel activities on various types of cells, including rat neonatal cardiomyocytes. Here we evaluated the effects of ECP on rat cardiac myoblast H9c2 cells. Our results showed that ECP enhanced the survival of the cells, in part by promoting the ERK and Akt/GSK-3β signaling pathways. ECP attenuated the cytotoxic effects of H2O2 on H9c2 cells as well as the production of reactive oxygen species, the number of apoptotic cells and caspase 3/7 activity in the cells. In conclusion, ECP activated the ERK and Akt/GSK-3β pathways, resulting in anti-oxidative effects on H9c2 cells that attenuated apoptosis. |
Keywords | ECP reactive oxygen species Akt ERK |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2015-06 |
Volume | volume69 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 145 |
End Page | 153 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 26101190 |
Web of Science KeyUT | 000356903000003 |
Author | Bekku, Yoko| Ninomiya, Yoshifumi| Oohashi, Toshitaka| |
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Published Date | 2012-04-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume124 |
Issue | issue1 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/31831 |
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FullText URL | fulltext.pdf |
Author | Hatipoglu, Omer Faruk| Hirohata, Satoshi| Yaykasli, Kursat Oguz| Cilek, Mehmet Zeynel| Demircan, Kadir| Shinohata, Ryoko| Yonezawa, Tomoko| Oohashi, Toshitaka| Kusachi, Shozo| Ninomiya, Yoshifumi| |
Abstract | ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs 1) is an inflammatory-induced gene. We have previously reported that ADAMTS1 was strongly but transiently expressed in the infarcted heart. In this study, we investigated whether a 3'-untranslated region (UTR) affects the mRNA stability of this gene. When stimulated with tissue necrosis factor (TNF)-alpha, the expression level of ADAMTS1 mRNA rapidly increased, but the induction of ADAMTS1 mRNA peaked at 6h after stimulation, after which the expression levels of ADAMTS1 mRNA decreased. The 3'-UTR ADAMTS1 mRNA contains multiple adenine and uridine-rich elements, suggesting that the 3'-UTR may regulate gene stability. The addition of actinomycin D, an RNA synthesis inhibitor, demonstrated the decay of induced ADAMTS1 mRNA by TNF-alpha. Furthermore, a region containing multiple AUUUA motifs within the ADAMTS1 3'-UTR destabilized transfected Enhanced Green Fluorescence Protein (EGFP) mRNA expression. These results demonstrated that the ADAMTS1 3'-UTR may regulate the expression of ADAMTS1 mRNA. |
Keywords | ADAMTS1 gene regulation metalloproteinase |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2009-04 |
Volume | volume63 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 79 |
End Page | 85 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 19404339 |
Web of Science KeyUT | 000265457600002 |
Author | Demircan, Kadir| Hirohata, Satoshi| Nishida, Keiichiro| Hatipoglu, Omer F.| Oohashi, Toshitaka| Yonezawa, Tomoko| Apte, Suneel S.| Ninomiya, Yoshifumi| |
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Published Date | 2005-5 |
Publication Title | Arthritis & Rheumatism |
Volume | volume52 |
Issue | issue5 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/31728 |
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FullText URL | fulltext.pdf |
Author | Nomoto, Hiroyuki| Oohashi, Toshitaka| Hirakawa, Satoshi| Ueki, Yasuyoshi| Ohtsuki, Hiroshi| Ninomiya, Yoshifumi| |
Abstract | We herein determined by fluorescence in situ hybridization the chromosomal localization of 2 human genes, BRAL1 and BCAN, both of which belong to the link-module superfamily, i.e. to the same band of chromosome 1q21-23. Further analysis of the genomic organization of BRAL1 and BCAN revealed that the BRAL1 gene was located 20-kb upstream of the BCAN start site. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the BCAN gene. High heterozygosity (0.79) makes this polymorphism a useful marker in the study of genetic disorders. Knowledge of the structure of the genes and the marker provides essential information for further analysis of the gene locus at chromosome 1q21-23. |
Keywords | BRAL1 BCAN FISH schizophrenia polymorphic marker |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2002-02 |
Volume | volume56 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 25 |
End Page | 29 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 11873941 |
Web of Science KeyUT | 000174031300005 |
Author | 大橋 俊孝| |
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Published Date | 1992-03-28 |
Content Type | Thesis or Dissertation |