FullText URL K001796.pdf
Author 大塚 文男|
Published Date 1998-03-31
Content Type Thesis or Dissertation
Grant Number 甲第1796号
Granted Date 1998-03-31
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language 日本語
FullText URL fulltext.pdf
Author Harada, Ko| Murakami, Shuntaro| Tokumasu, Kazuki| Togawa, Yu| Otsuka, Fumio|
Keywords hypercapnic respiratory failure myxedema coma sick sinus syndrome
Published Date 2019-06-25
Publication Title Journal of General and Family Medicine
Volume volume20
Issue issue5
Publisher Wiley
Start Page 206
End Page 208
ISSN 2189-7948
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors.
File Version publisher
PubMed ID 31516809
DOI 10.1002/jgf2.267
Web of Science KeyUT 000484673300008
Related Url isVersionOf https://doi.org/10.1002/jgf2.267
FullText URL fulltext.pdf
Author Yamamoto, Akira| Nishimura, Yoshito| Obika, Mikako| Morizane, Yuki| Otsuka, Fumio|
Keywords anemia anemic retinopathy rectal cancer retinal detachment
Published Date 2020-04-13
Publication Title Clinical Case Reports
Publisher Wiley
ISSN 2050-0904
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
DOI 10.1002/ccr3.2833
Web of Science KeyUT 000525973300001
Related Url isVersionOf https://doi.org/10.1002/ccr3.2833
Author Nishimura, Yoshito| Hanayama, Yoshihisa| Fujii, Nobuharu| Kondo, Eisei| Otsuka, Fumio|
Keywords TAFRO syndrome Castleman disease chief complaint procalcitonin immunoglobulin
Note This is the peer reviewed version of the following article: Nishimura Y. et. al. Comparison of the clinical characteristics of TAFRO syndrome and idiopathic multicentric Castleman disease in general internal medicine: a 6‐year retrospective study. Internal Medicine Journal 50(2), 184-191 (2020), which has been published in final form at https://doi.org/10.1111/imj.14404. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. </br>This fulltext is available in Feb. 2021.|
Published Date 2019-06-18
Publication Title Internal Medicine Journal
Volume volume50
Issue issue2
Publisher Wiley
Start Page 184
End Page 191
ISSN 14440903
NCID AA1156202X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31211492
DOI 10.1111/imj.14404
Web of Science KeyUT 000529458300007
Related Url isVersionOf https://doi.org/10.1111/imj.14404
FullText URL fulltext.pdf
Author Sazumi, Yosuke| Nishimura, Yoshito| Otsuka, Yuki| Mizuta, Yuki| Nakano, Yasuhiro| Sakae, Hiroyuki| Otsuka, Fumio|
Keywords extrahepatic portosystemic shunt hepatic encephalopathy portal hypertension and altered mental status
Published Date 2020-06-01
Publication Title Clinical Case Reports
Publisher Wiley
ISSN 2050-0904
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
DOI 10.1002/ccr3.2986
Web of Science KeyUT 000536667000001
Related Url isVersionOf https://doi.org/10.1002/ccr3.2986
FullText URL BMCMedEduc_19_1_87.pdf
Author Yamamoto, Akira| Obika, Mikako| Mandai, Yasuhiro| Murakami, Taku| Miyoshi, Tomoko| Ino, Hideo| Kataoka, Hitomi| Otsuka, Fumio|
Keywords Simulation-based learning Peer-assisted learning Lecture Postgraduate education Junior residents
Published Date 2019-03-20
Publication Title BMC Medical Education
Volume volume19
Issue issue1
Publisher BMC
Start Page 87
ISSN 1472-6920
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 30894162
DOI 10.1186/s12909-019-1509-y
Web of Science KeyUT 000462328100001
Related Url isVersionOf https://doi.org/10.1186/s12909-019-1509-y
JaLCDOI 10.18926/AMO/30375
FullText URL fulltext.pdf
Author Mimura, Yukari| Ogura, Toshio| Yamauchi, Takayoshi| Otsuka, Fumio| Oishi, Tetsuya| Harada, Kazushi| Hashimoto, Masami| Ota, Zensuke|
Abstract <p>We recently reported that stimulation of the arginine vasopressin (AVP) V1-receptor enhanced the pressor response in spontaneously hypertensive rats (SHR). In the present study, we investigated acute changes in systolic blood pressure (SBP) and heart rate (HR) after intravenous injections of AVP, OPC-21268 (a V1-receptor antagonist), and OPC-31260 (a V2-receptor antagonist), in anesthetized DOCA-salt hypertensive rats (DOCA) and age-matched sham-operated Wistar rats (control) to determine whether the pressor effect is specific to SHR or is present in other hypertensive animal models. SBP increased significantly in DOCA rats 9 min after injection of AVP 5 ng/kg without a concomitant increase in HR. Neither OPC-21268 3mg/kg nor OPC-31260 3mg/kg caused significant changes in SBP or HR. SBP tended to increase when AVP was administered after injection of OPC-31260. HR increased significantly 15 min after the combined treatment with OPC-31260 and AVP in DOCA rats compared with control rats. SBP did not change significantly when AVP was administered after injection of OPC-21268 in DOCA or control rats, but HR decreased significantly from 1 to 4 min after injection of AVP in DOCA rats. Our results suggest that V1-receptor stimulation does not enhance the pressor response in the DOCA rat, which is a model of volume-dependent hypertension, suggesting that the AVP system, especially V1-receptor, is not as important in the development or maintenance of hypertension in DOCA rats as in SHR.</p>
Keywords vasopressin DOCA-salt hypertensive rat V1-and V2-receptor antagonist spontaneously hypertesive rat(SHR) OPC-21268
Amo Type Article
Published Date 1995-08
Publication Title Acta Medica Okayama
Volume volume49
Issue issue4
Publisher Okayama University Medical School
Start Page 187
End Page 194
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 7502678
Web of Science KeyUT A1995RR97800002
JaLCDOI 10.18926/AMO/40128
FullText URL 64_4_213.pdf
Author Otani, Hiroyuki| Otsuka, Fumio| Inagaki, Kenichi| Suzuki, Jiro| Makino, Hirofumi|
Abstract Aldosterone production occurs in the adrenal cortex, and is regulated primarily by angiotensin II (Ang II), potassium and adrenocorticotropin (ACTH). In the presence of the aldosterone stimulators, steroidogenesis is further governed by local autocrine and/or paracrine factors in the adrenal cortex. We reported the presence of functional bone morphogenetic protein (BMP) system in the adrenal cortex and also demonstrated that BMP-6 increases Ang II-induced aldosterone production, which could be involved in the "aldosterone breakthrough" phenomenon. Aldosterone breakthrough is the phenomenon by which circulating aldosterone concentrations increase above pre-treatment levels after long-term therapy with ACE inhibitors or Ang II type 1 receptor antagonists (ARB). This phenomenon may lead to important clinical consequences since increased aldosterone in a high-salt state facilitates cardiovascular and renal damage in hypertensive patients. We found that long-term ARB treatment reverses the reduction of aldosterone synthesis by adrenocortical cells, thereby causing "cellular aldosterone breakthrough". The availability of BMP-6 in the adrenal cortex may be at least partly involved in the occurrence of cellular escape from aldosterone suppression under chronic treatment with ARB.
Keywords adrenal cortex angiotensin II aldosterone bone morphogenetic protein
Amo Type Review
Published Date 2010-08
Publication Title Acta Medica Okayama
Volume volume64
Issue issue4
Publisher Okayama University Medical School
Start Page 213
End Page 218
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 20802537
Web of Science KeyUT 000281384400001
JaLCDOI 10.18926/AMO/49665
FullText URL 67_2_75.pdf
Author Otsuka, Fumio|
Abstract New biological activities of bone morphogenetic proteins (BMPs) in the endocrine system have recently been revealed. The BMP system is composed of approximately 30 ligands and preferential combinations of type I and type II receptors. The BMP system not only induces bone formation but also plays unique tissue-specific roles in various organs. For instance, the ovarian BMP system is a physiological inhibitor of luteinization in growing ovarian follicles. In the ovary, the expression of oocyte-derived BMP-15 is critical for female reproduction. In the pituitary, BMP-4 is a key player for initial development of the anterior pituitary, while it is also functionally involved in some differentiated pituitary tumors, including prolactinoma and Cushingʼs disease. In the adrenal glands, BMP-6 and BMP-4 modulate aldosterone and catecholamine production, respectively, which contributes to a functional interaction between the cortex and medulla. In the present review, recent advances in BMP biology in the field of endocrinology are described and the possibility for clinical application of BMP activity is discussed.
Keywords bone morphogenetic protein folliculogenesis pituitary adenoma steroidogenesis transforming growth factor
Amo Type Review
Published Date 2013-04
Publication Title Acta Medica Okayama
Volume volume67
Issue issue2
Publisher Okayama University Medical School
Start Page 75
End Page 86
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23603923
Web of Sience KeyUT 000317801700001
JaLCDOI 10.18926/AMO/51067
FullText URL 67_4_227.pdf
Author Ryuko, Hiromasa| Otsuka, Fumio|
Abstract Primary care physicians often encounter patients with fever of unknown origin and without apparent causes. Recent advances in laboratory medicine have facilitated diagnostic procedures;however, it is still difficult to determine the critical febrile factor at an early stage. We reviewed the medical records of 174 patients who were admitted due to a chief complaint of fever (>37.5℃) to our hospital during the period from 2004 to 2010. The patients were categorized into patients with infection, inflammation, neoplasm and drug-induced fever. Based on the analysis done by category, it was revealed that the patient's age, body temperature and duration of fever were closely related to the final diagnosis. Serum CRP levels were significantly low in the nonbacterial infection group, while serum levels of sIL-2R were high in neoplasm and drug-induced cases. CRP level on admission was weakly but significantly correlated with body temperature, while duration of fever was inversely related to body temperature. The effectiveness of PET-CT and tissue biopsy for diagnosis was considerably high, particularly in the categories of neoplasm and nonspecific inflammation, respectively, though the effectiveness of bacterial culture was low. Thus, a careful review of physical and laboratory information including body temperature, CRP level, duration of fever, gender difference and history of medication is indispensable for diagnosis. Stepwise categorization and disease classification by comprehensive and systemic checkup are very helpful for determining the causes of fever.
Keywords computed tomography (CT) C-reactive protein (CRP) fluorodeoxyglucose positron emission tomography (FDG-PET) fever of unknown origin (FUO) soluble interleukin-2 receptor (sIL-2R)
Amo Type Original Article
Published Date 2013-08
Publication Title Acta Medica Okayama
Volume volume67
Issue issue4
Publisher Okayama University Medical School
Start Page 227
End Page 237
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23970321
Web of Science KeyUT 000323470100004
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/51947
JaLCDOI 10.18926/AMO/52402
FullText URL 68_2_57.pdf
Author Hagiya, Hideharu| Naito, Hiromichi| Hagioka, Shingo| Okahara, Shuji| Morimoto, Naoki| Kusano, Nobuchika| Otsuka, Fumio|
Abstract The effect of antibiotics during the perioperative period of percutaneous dilatational tracheostomy (PDT) is still controversial. A total of 297 patients who underwent the PDT procedure were divided into 2 groups:those administered antibiotics perioperatively and those not administered antibiotics. Wound infections were noted in 7 cases (incidence rate, 2.36%) and no death was recorded. Of the 69 patients without antibiotics, 5 developed wound infections (incidence rate, 7.25%), while only 2 of the 228 patients with antibiotics developed wound infections (incidence rate, 0.88%) (p=0.002;risk ratio, 8.82;95% confidence interval, 1.67-46.6). Of the 7 cases of wound infection, 5 cases occurred during the early period after PDT (within 7 days). Collectively, the present results suggest that prophylactic administration of antibiotics may prevent the incidence of PDT-induced wound infection, especially in the early phase after the PDT procedures. The need for antibiotics in PDT should be reconsidered.
Keywords airway management critically ill patient percutaneous dilatational tracheostomy surgical site infection
Amo Type Original Article
Published Date 2014-04
Publication Title Acta Medica Okayama
Volume volume68
Issue issue2
Publisher Okayama University Medical School
Start Page 57
End Page 62
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24743781
Web of Science KeyUT 000334652700001
JaLCDOI 10.18926/AMO/52658
FullText URL 68_3_171.pdf
Author Hagiya, Hideharu| Matsumoto, Mitsuaki| Yamasawa, Takahiko| Haruki, Yuto| Otsuka, Fumio|
Abstract A 79-year-old man who had undergone a right femoropopliteal (FP) bypass operation 6 weeks previously was diagnosed with vascular graft infection caused by Staphylococcus lugdunensis. Another FP bypass operation was performed, with long-term administration of antibiotics, and the patient eventually recovered well without any recurrences for over 2 years. Although S. lugdunens is classified as coagulase-negative Staphylococcus, its pathogenicity has been reported to be equal to that of S. aureus. Based on the literature review, the organism characteristically colonizes the inguinal area of human skin;thus, operations such as FP bypass grafting may place patients at a relatively high risk for infection by S. lugdunensis, a potentially high-pathogenicity organism.
Keywords coagulase-negative Staphylococcus (CNS) femoropopliteal (FP) bypass Staphylococcus lugdunensis vacuum-assisted closure (VAC) therapy vascular graft infection (VGI)
Amo Type Case Report
Published Date 2014-06
Publication Title Acta Medica Okayama
Volume volume68
Issue issue3
Publisher Okayama University Medical School
Start Page 171
End Page 175
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24942796
Web of Science KeyUT 000337655600007
FullText URL CTR375_3_743.pdf
Author Ojima, Fumiya| Saito, Yuka| Tsuchiya, Yukiko| Ogoshi, Maho| Fukamachi, Hiroshi| Inagaki, Kenichi| Otsuka, Fumio| Takeuchi, Sakae| Takahashi, Sumio|
Keywords Estrogen Follicle Mouse Ovary Runx3
Published Date 2018-10-30
Publication Title Cell and Tissue Research
Volume volume375
Issue issue3
Publisher Springer
Start Page 743
End Page 754
ISSN 0302-766X
NCID AA00600105
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30377784
DOI 10.1007/s00441-018-2947-2
Web of Science KeyUT 000460535300015
Related Url isVersionOf https://doi.org/10.1007/s00441-018-2947-2
JaLCDOI 10.18926/AMO/53342
FullText URL 69_2_123.pdf
Author Waseda, Koichi| Hagiya, Hideharu| Hanayama, Yoshihisa| Terasaka, Tomohiro| Kimura, Kosuke| Tsuzuki, Takao| Hasegawa, Kou| Nada, Takahiro| Nakamura, Eri| Murakami, Kazutoshi| Kondo, Eisei| Otsuka, Fumio|
Abstract An 81-year-old Japanese male with primary Sjögren syndrome (pSS) developed a low-grade fever and productive cough which were refractory to antibiotic therapy. Based on the high level of eosinophils observed in his bronchial alveolar lavage, he was diagnosed with chronic eosinophilic pneumonia (CEP) and successfully treated by oral prednisolone. Interstitial lung diseases associated with pSS (pSS-ILDs) usually present as nonspecific interstitial pneumonia or usual interstitial pneumonia; therefore, the present case is extremely unique in that the patientʼs condition was complicated with CEP. A diagnosis of advanced gallbladder cancer was made in the patientʼs clinical course, suggesting the advisability of a whole-body workup in cases of pSS, especially in elderly patients.
Keywords bronchial alveolar lavage eosinophilic pneumonia eosinophilia interstitial lung diseases Sjögren syndrome
Amo Type Case Report
Published Date 2015-04
Publication Title Acta Medica Okayama
Volume volume69
Issue issue2
Publisher Okayama University Medical School
Start Page 123
End Page 127
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25899635
Web of Science KeyUT 000353181700008
Author Otsuka, Fumio|
Published Date 2007-09-03
Publication Title 岡山医学会雑誌
Volume volume119
Issue issue2
Content Type Article
Author 武田 昌也| 大塚 文男| 中村 一文| 稲垣 兼一| 鈴木 二郎| 三浦 大志| 藤尾 栄起| 松原 広己| 伊達 洋至| 大江 透| 槇野 博史|
Published Date 2006-05-01
Publication Title 岡山医学会雑誌
Volume volume118
Issue issue1
Content Type Journal Article
Author Otani, Hiroyuki| Otsuka, Fumio| Makino, Hirofumi|
Published Date 2010-04-01
Publication Title 岡山医学会雑誌
Volume volume122
Issue issue1
Content Type Journal Article
Author Otani, Hiroyuki| Otsuka, Fumio| Inagaki, Kenichi| Suzuki, Jiro| Miyoshi, Tomoko| Kano, Yoshihiro| Goto, Junko| Ogura, Toshio| Makino, Hirofumi|
Published Date 2008-06-25
Publication Title Endocrinology
Volume volume149
Issue issue6
Content Type Journal Article
Author Tsukamoto, Naoko| Otsuka, Fumio| Miyoshi, Tomoko| Inagaki, Kenichi| Nakamura, Eri| Suzuki, Jiro| Ogura, Toshio| Iwasaki, Yasumasa| Makino, Hirofumi|
Published Date 2011-01-30
Publication Title Molecular and Cellular Endocrinology
Volume volume332
Issue issue1-2
Content Type Journal Article
Author Mimura, Yukari| Ogura, Toshio| Otsuka, Fumio|
Published Date 2011-06-25
Publication Title 岡山大学大学院教育学研究科研究集録
Volume volume147
Content Type Departmental Bulletin Paper