FullText URL fulltext.pdf
Author Hotta, Yoshifumi| Nishida, Keiichiro| Yoshida, Aki| Nasu, Yoshihisa| Nakahara, Ryuichi| Naniwa, Shuichi| Shimizu, Noriyuki| Ichikawa, Chinatsu| Lin, Deting| Fujiwara, Tomohiro| Ozaki, Toshifumi|
Keywords osteoarthritis chondrocyte mechanical stress tankyrases XAV939 SOX9 ADAMTS-5 MMP-13 IL-1β NF-κB β-catenin
Published Date 2024-01-24
Publication Title International Journal of Molecular Sciences
Volume volume25
Issue issue3
Publisher MDPI
Start Page 1443
ISSN 1661-6596
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 by the authors.
File Version publisher
PubMed ID 38338721
DOI 10.3390/ijms25031443
Web of Science KeyUT 001161430700001
Related Url isVersionOf https://doi.org/10.3390/ijms25031443
JaLCDOI 10.18926/AMO/66673
FullText URL 78_1_071.pdf
Author Kaneda, Daisuke| Nishida, Keiichiro| Nasu, Yoshihisa| Nakahara, Ryuichi| Harada, Ryozo| Hotta, Yoshifumi| Naniwa, Shuichi| Ozaki, Toshifumi|
Abstract We retrospectively investigated the mid-term outcomes of arthroplasty using the AVANTA silicone implant for thumb metacarpophalangeal (MCP) joints with boutonniere deformity in patients with rheumatoid arthritis (RA). This study involved 36 thumbs of 33 RA patients with a mean follow-up period of 5.1 years (range, 2.0-13.3). Postoperatively, the mean extension was significantly increased and the mean flexion was significantly decreased (p<0.001, p<0.001, respectively), resulting in the mean arc of range of motion (ROM) shifting in the direction of extension after surgery. Implant fracture was observed in 10 thumbs (28%), and 4 of these (11%) underwent revision surgery. The survivorship with implant fracture and revision surgery as endpoints were 73.4% and 91.8% at 5 years, respectively. The preoperative arc of ROM and the postoperative flexion range of the implant-fracture group were significantly greater than those in the no-implant-fracture group (p=0.039, 0.034, respectively). These results suggest the importance of patient education and careful rehabilitation to prevent excessive flexion. Overall, the AVANTA silicone implant showed a relatively high rate of implant fracture at our institute.
Keywords AVANTA silicone implant boutonniere deformity implant fracture thumb metacarpophalangeal joint arthroplasty rheumatoid arthritis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-02
Volume volume78
Issue issue1
Publisher Okayama University Medical School
Start Page 71
End Page 78
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
FullText URL fulltext.pdf
Author Saito, Taichi| Nakamichi, Ryo| Nakahara, Ryuichi| Nishida, Keiichiro| Ozaki, Toshifumi|
Keywords hand surgery rehabilitation open surgical release trigger finger
Published Date 2023-11-20
Publication Title Journal of Clinical Medicine
Volume volume12
Issue issue22
Publisher MDPI
Start Page 7187
ISSN 2077-0383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by the authors.
File Version publisher
PubMed ID 38002801
DOI 10.3390/jcm12227187
Web of Science KeyUT 001123419500001
Related Url isVersionOf https://doi.org/10.3390/jcm12227187
FullText URL fulltext20230817-03.pdf
Author Nishida, Keiichiro| Nasu, Yoshihisa| Hashizume, Kenzo| Okita, Shunji| Nakahara, Ryuichi| Saito, Taichi| Ozaki, Toshifumi| Inoue, Hajime|
Keywords Total elbow arthroplasty Rheumatoid arthritis Unlinked elbow Less than fifty years old
Published Date 2023-01-13
Publication Title Bone & Joint Open
Volume volume4
Issue issue1
Publisher British Editorial Society of Bone & Joint Surgery
Start Page 19
End Page 26
ISSN 2633-1462
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Author(s) et al.
File Version publisher
PubMed ID 36636881
DOI 10.1302/2633-1462.41.bjo-2022-0151.r1
Web of Science KeyUT 001042052200001
Related Url isVersionOf https://doi.org/10.1302/2633-1462.41.BJO-2022-0151.R1
FullText URL fulltext.pdf
Author Tsuji, Hironori| Tetsunaga, Tomoko| Tetsunaga, Tomonori| Misawa, Haruo| Oda, Yoshiaki| Takao, Shinichiro| Nishida, Keiichiro| Ozaki, Toshifumi|
Keywords caregiver burden chronic pain fear-avoidance model self-efficacy Zarit Burden Interview
Published Date 2022-09-30
Publication Title Medicine
Volume volume101
Issue issue39
Publisher Lippincott Williams & Wilkins
Start Page e30802
ISSN 0025-7974
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 the Author(s).
File Version publisher
PubMed ID 36181114
DOI 10.1097/MD.0000000000030802
Web of Science KeyUT 000862039900121
Related Url isVersionOf https://doi.org/10.1097/MD.0000000000030802
FullText URL fulltext.pdf
Author Horita, Masahiro| Nishida, Keiichiro| Nasu, Yoshihisa| Nakahara, Ryuichi| Saiga, Kenta| Hamada, Masanori| Ozaki, Toshifumi|
Keywords forefoot surgery arthrodesis shortening oblique osteotomy patient-reported outcome rheumatoid arthritis
Published Date 2022-08-07
Publication Title Journal Of Orthopaedic Surgery
Volume volume30
Issue issue2
Publisher Sage Publications Ltd.
Start Page 10225536221117903
ISSN 1022-5536
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2022
File Version publisher
PubMed ID 35938600
DOI 10.1177/10225536221117903
Web of Science KeyUT 000839038400001
Related Url isVersionOf https://doi.org/10.1177/10225536221117903
FullText URL fulltext.pdf
Author Tabuchi, Masako| Inoue, Katsumi| Usui-Kataoka, Hitomi| Kobayashi, Kazuko| Teramoto, Misako| Takasugi, Koji| Shikata, Kenichi| Yamamura, Masahiro| Ando, Kenji| Nishida, Keiichiro| Kasahara, Junko| Kume, Noriaki| Lopez, Luis R.| Mitsudo, Kazuaki| Nobuyoshi, Masakiyo| Yasuda, Tatsuji| Kita, Toru| Makino, Hirofumi| Matsuura, Eiji|
Keywords beta 2-glycoprotein I oxidized LDL/beta 2-glycoprotein I complexes diabetes mellitus oxidized LDL
Published Date 2007-04
Publication Title Journal Of Lipid Research
Volume volume48
Issue issue4
Publisher ELSEVIER
Start Page 768
End Page 781
ISSN 0022-2275
NCID AA00701215
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2007 by the American Society for Biochemistry and Molecular Biology, Inc.
File Version publisher
PubMed ID 17261875
DOI 10.1194/jlr.M600414-JLR200
Web of Science KeyUT 000245627100003
Related Url isVersionOf https://doi.org/10.1194/jlr.M600414-JLR200
FullText URL fulltext.pdf
Author Inai, Ryota| Nakahara, Ryuichi| Morimitsu, Yusuke| Akagi, Noriaki| Marukawa, Youhei| Matsushita, Toshi| Tanaka, Takashi| Tada, Akihiro| Hiraki, Takao| Nasu, Yoshihisa| Nishida, Keiichiro| Ozaki, Toshifumi| Kanazawa, Susumu|
Keywords Osteoporosis Bone density Tomography (x-ray computed) X-ray microtomography
Published Date 2021-01-28
Publication Title European Radiology Experimental
Volume volume4
Issue issue1
Publisher Springer nature
Start Page 4
ISSN 2509-9280
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 31993864
DOI 10.1186/s41747-019-0135-0
Web of Science KeyUT 000705622700001
Related Url isVersionOf https://doi.org/10.1186/s41747-019-0135-0
FullText URL fulltext.pdf
Author Takeshita, Ayumu| Nishida, Keiichiro| Yoshida, Aki| Nasu, Yoshihisa| Nakahara, Ryuichi| Kaneda, Daisuke| Ohashi, Hideki| Ozaki, Toshifumi|
Published Date 2021-07-07
Publication Title PLOS ONE
Volume volume16
Issue issue7
Publisher Public Library Science
Start Page e0254268
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Takeshita et al.
File Version publisher
PubMed ID 34234380
DOI 10.1371/journal.pone.0254268
Web of Science KeyUT 000674294100020
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0254268
FullText URL fulltext.pdf
Author Ohashi, Hideki| Nishida, Keiichiro| Nasu, Yoshihisa| Saiga, Kenta| Nakahara, Ryuichi| Horita, Masahiro| Okita, Shunji| Ozaki, Toshifumi|
Keywords lesser toe metatarsophalangeal joint rheumatoid arthritis radiographic measurement grading system
Published Date 2021-07-15
Publication Title International Journal of Environmental Research and Public Health
Volume volume18
Issue issue14
Publisher MDPI
Start Page 7520
ISSN 1660-4601
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 34299970
DOI 10.3390/ijerph18147520
Web of Science KeyUT 000676598200001
Related Url isVersionOf https://doi.org/10.3390/ijerph18147520
FullText URL fulltext.pdf
Author Tetsunaga, Tomoko| Tetsunaga, Tomonori| Nishida, Keiichiro| Misawa, Haruo| Takigawa, Tomoyuki| Yamane, Kentaro| Tsuji, Hironori| Takei, Yoshitaka| Ozaki, Toshifumi|
Keywords Peripheral neuropathic pain Mirogabalin Pregabalin Adverse event
Published Date 2020-05-26
Publication Title Journal of Orthopaedic Surgery and Research
Volume volume15
Issue issue1
Publisher Springer
Start Page 191
ISSN 1749-799X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 32456647
DOI 10.1186/s13018-020-01709-3
Web of Science KeyUT 000538017400002
Related Url isVersionOf https://doi.org/10.1186/s13018-020-01709-3
FullText URL fulltext.pdf
Author Ohtsuki, Takashi| Hatipoglu, Omer F.| Asano, Keiichi| Inagaki, Junko| Nishida, Keiichiro| Hirohata, Satoshi|
Keywords cell migration-inducing hyaluronidase 1 (CEMIP) chondrocyte hyaluronan mechanical strain nuclear factor kappa B (NF-kappa B) osteoarthritis
Published Date 2020-04-29
Publication Title International Journal of Molecular Sciences
Volume volume21
Issue issue9
Publisher MDPI
Start Page 3140
ISSN 1422-0067
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32365591
DOI 10.3390/ijms21093140
Web of Science KeyUT 000535581700111
Related Url isVersionOf https://doi.org/10.3390/ijms21093140
FullText URL JOS_015_Fulltext.pdf JOS_015_Figures.pptx
Author Okazaki, Yuki| Furumatsu, Takayuki| Kamatsuki, Yusuke| Nishida, Keiichiro| Nasu, Yoshihisa| Nakahara, Ryuichi| Saito, Taichi| Ozaki, Toshifumi|
Published Date 2020-03-26
Publication Title Journal of Orthopaedic Science
Volume volume26
Issue issue2
Publisher Elsevier
Start Page 230
End Page 236
ISSN 09492658
NCID AA11052566
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Japanese Orthopaedic Association.
File Version author
PubMed ID 32223991
DOI 10.1016/j.jos.2020.02.015
Related Url isVersionOf https://doi.org/10.1016/j.jos.2020.02.015
JaLCDOI 10.18926/AMO/57957
FullText URL 74_1_77.pdf
Author Endo, Hirosuke| Akazawa, Hirofumi| Yashiro, Masato| Yamada, Kazuki| Sanki, Tomoaki| Tetsunaga, Tomonori| Nishida, Keiichiro| Furumatsu, Takayuki| Ozaki, Toshifumi|
Abstract Idiopathic chondrolysis of the hip (ICH), a very rare disorder of unknown etiology, occurs mainly in female adolescents. Characterized by pain, limp, stiffness and radiological narrowing joint space from the rapid destruction of the articular cartilage, ICH sometimes results in ankyloses. We present the case of a 10-year-old girl diagnosed with ICH based on arthroscopic inspection and synovium biopsy. The femoral deformity appeared gradually, like a cam-type femoroacetabular impingement. She was treated with intensive rehabilitation and immunosuppressive drug. We later performed an arthroscopic bumpectomy for residual symptoms. She achieved a favorable outcome as a 15-year-old at the latest follow-up.
Keywords idiopathic chondrolysis hip joint medication bump arthroscopy
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2020-02
Volume volume74
Issue issue1
Publisher Okayama University Medical School
Start Page 77
End Page 81
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32099253
Web of Science KeyUT 000516606200012
NAID 120006795624
JaLCDOI 10.18926/AMO/57720
FullText URL 73_6_537.pdf
Author Takahara, Yasuhiro| Nishida, Keiichiro| Nakashima, Hirotaka| Ochi, Nobuaki| Uchida, Yoichiro| Kato, Hisayoshi| Itani, Satoru| Nakamura, Makoto| Iwasaki, Yuichi| Tsujimura, Yoshitaka|
Abstract High tibial osteotomy (HTO) procedure is generally contraindicated in rheumatoid arthritis (RA) patients because synovial inflammation may exacerbate joint damage post-surgery. The natural course of joint destruction in RA changed dramatically with new treatment strategies and the introduction of biologic disease-modifying anti-rheumatic drugs (bDMARDs). We report the cases of two RA patients who underwent HTO and whose disease activities were well controlled by bDMARDs. Despite their short follow-up periods, they showed acceptable objective and subjective clinical results. We believe that the combination of bDMARDs and HTO can be indicated for selected RA patients before total knee arthroplasty.
Keywords high tibial osteotomy rheumatoid arthritis biologic DMARD knee surgery
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2019-12
Volume volume73
Issue issue6
Publisher Okayama University Medical School
Start Page 537
End Page 542
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31871338
Web of Science KeyUT 000503431400011
FullText URL fulltext.pdf
Author Ohtsuki, Takashi| Shinaoka, Akira| Kumagishi-Shinaoka, Kanae| Asano, Keiichi| Hatipoglu, Omer Faruk| Inagaki, Junko| Takahashi, Ken| Oohashi, Toshitaka| Nishida, Keiichiro| Naruse, Keiji| Hirohata, Satoshi|
Published Date 2019-10-15
Publication Title Experimental Cell Research
Volume volume383
Issue issue2
Publisher Elsevier
Start Page 111556
ISSN 00144827
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors. Published by Elsevier Inc.
File Version publisher
PubMed ID 31415758
DOI 10.1016/j.yexcr.2019.111556
Web of Science KeyUT 000488145400017
Related Url isVersionOf https://doi.org/10.1016/j.yexcr.2019.111556
Author Nishida, Keiichiro| Hashizume, Kenzo| Ozawa, Masatsugu| Takeshita, Ayumu| Kaneda, Daisuke| Nakahara, Ryuichi| Nasu, Yoshihisa| Shimamura, Yasunori| Inoue, Hajime| Ozaki, Toshifumi|
Published Date 2017-02
Publication Title Acta Medica Okayama
Volume volume71
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/54824
JaLCDOI 10.18926/AMO/54811
FullText URL 70_6_477.pdf
Author Nishida, Keiichiro| Machida, Takahiro| Horita, Masahiro| Hashizume, Kenzo| Nakahara, Ryuichi| Nasu, Yoshihisa| Ohashi, Hideki| Saiga, Kenta| Ozaki, Toshifumi|
Abstract The metatarsophalangeal (MTP) joints are often and predominantly affected in rheumatoid arthritis. The aim of the current study was to describe surgical techniques of shortening oblique osteotomy for lesser metatarsal bone with screw fixation at the osteotomy site, and to investigate the short-term clinical outcomes of our procedure. Twenty-seven feet (78 toes) of 24 RA patients underwent the shortening oblique osteotomy for the correction of deformity at the lesser MTP joints. The average Japanese Society of Surgery of the Foot (JSSF) standard rating system for the RA foot and ankle scale improved significantly from 59.6 points preoperatively to 88.3 points postoperatively (p<0.001). Twenty-four feet (89 ) were free from metatarsalgia and symptomatic callosities at the lesser MTP joint after surgery. Our present findings showed satisfactory early clinical outcomes of the shortening oblique osteotomy of the metatarsal bone with screw fixation for RA forefoot.
Keywords shortening oblique osteotomy rheumatoid arthritis forefoot screw fixation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2016-12
Volume volume70
Issue issue6
Publisher Okayama University Medical School
Start Page 477
End Page 483
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28003673
JaLCDOI 10.18926/AMO/53119
FullText URL 69_1_29.pdf
Author Nakahara, Ryuichi| Nishida, Keiichiro| Hashizume, Kenzo| Harada, Ryouzou| Machida, Takahiro| Horita, Masahiro| Ohtsuka, Aiji| Ozaki, Toshifumi|
Abstract The outcome measures in rheumatology clinical trials (OMERACT) scores are the most mature quantitation system for rheumatoid arthritis (RA) on magnetic resonance imaging (MRI). Direct measuring techniques of synovial volume have been reported with good reproducibility, although few reports have demonstrated the changes of these measures in response to treatment. To assess these clinical responses, we evaluated the correlation of the changes of clinical activity score 28-joints disease activity score (DAS28-CRP) with the changes of OMERACT scores and with synovial volume measurements. Eight RA patients who were treated by biologic agents were examined with MRI of the dominant affected wrist and finger joints before and one year after the treatment. The total OMERACT score was reduced from 48.0 to 41.3, and synovial volume was reduced from 15.4 to 8.8 milliliters. Positive correlations were seen between the changes of DAS28-CRP and the changes of OMERACT synovitis score (r=0.27), OMERACT total score (r=0.43) and synovial volume (r=0.30). Limited to synovium assessment, synovial volume showed a better correlation with DAS28-CRP than the OMERACT synovitis score. On the other hand, the OMERACT total score showed a higher correlation with DAS28-CRP than synovial volume, probably because the OMERACT total score includes scores for bone erosion and bone edema as well.
Keywords magnetic resonance imaging rheumatoid arthritis outcome measures in rheumatology clinical trials scoring system direct volume measuring medical work station
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2015-02
Volume volume69
Issue issue1
Publisher Okayama University Medical School
Start Page 29
End Page 35
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25703168
Web of Science KeyUT 000349740300003
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/53113
Title Alternative Hospital and clinic cooperation for the treatment of rheumatoid arthritis in Okayama Prefecture, Japan
FullText URL 126_209.pdf
Author Sada, Ken-ei| Nishida, Keiichiro| Yamanaka, Takao| Misaki, Kenta| Wakabayashi, Hiroshi| Shinoda, Junko| Takagi, Toru| Yano, Ryusuke| Nakamura, Akihiko| Nanba, Yoshifumi| Morita, Yoshitaka| Koyama, Yoshinobu| Yamamoto, Keiji| Ezawa, Kazuhiko| Ota, Yusuke| Yoshihara, Yoshiki| Miyoshi, Shinya| Natsumeda, Masamitsu| Usui, Masaaki| Yoshinaga, Yasuhiko| Hayashi, Takashi| Yamamura, Masahiro| Hashizume, Hiroyuki|
Abstract Objective: To survey the current status and problems of cooperation between clinics and hospitals in Okayama Prefecture, Japan for the treatment of rheumatoid arthritis (RA).  Methods: We distributed a questionnaire to 300 of the 983 Okayama Prefecture clinics that had either an internal medicine or orthopedic surgery department, from December 2013 to February 2014. The questionnaire covered practice pattern for RA treatment in clinics, current status of the hospital and clinic cooperation, and acceptance of the biologic therapy.  Results: One hundred clinics responded to the questionnaire. Seventy percent of the clinics reported making referrals to rheumatologists before the initiation of RA treatment, and half of the other 30% of the clinics administered methotrexate as the first-line treatment for RA by their own decision. Sixty-six clinics cooperated with flagship hospitals, conducting medical and laboratory examinations, providing prescriptions, and treating common diseases of patients. These clinics expected the cooperating rheumatologists to follow-up patients every 3 to 6 months and to make the diagnosis, make decisions regarding RA treatment changes, and perform surgery. Seventy-one percent of the clinics responded that cooperation with a hospital is possible even for patients who are administered biologics. As reasons for no cooperation with the flagship hospitals, clinics noted the lack of information about rheumatologists in the area and recent trends in the management of RA.  Conclusion: The current study reported, for the first time, the actual conditions of management of RA in clinics, as well as future problems of hospital and clinic cooperation in Okayama Prefecture.
Keywords 病診連携(hospital and clinic cooperation) 関節リウマチ(rheumatoid arthritis) 生物学的製剤(biologics) メトトレキサート(methotrexate)
Publication Title 岡山医学会雑誌
Published Date 2014-12-01
Volume volume126
Issue issue3
Start Page 209
End Page 215
ISSN 0030-1558
language Japanese
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.209
NAID 130004903246