ID | 817 |
Eprint ID | 817
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FullText URL | |
Title Alternative | グラヤノトキシンD環の化学修飾
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Author |
Iwasa, Junkichi
Kawanishi, Tetsuroh
Handa, Satoshi
Kamano, Hideki
Yamamoto, Shingo
Okamoto, Manabu
Takeda, Norimasa
Nakamura, Mikihiko
Masutani, Tetsuya
Shiro, Motoo
Baba, Naomichi
Seyama, Issei
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Abstract | Grayanotoxin (GTX), one of the lipid-soluble Na+ channel openers, contains four rings (A, B, C and D) and the chemical groups essential for the pharmacological action are located on the A- and B-rings. To study the biological significance of functional groups on the D-ring, 51 new derivatives were prepared from α-dihydro GTX- 11 . These new compounds and the previously prepared GTXS ere directly applied to the intracellular phase of internally perfused squid giant axons.
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Published Date | 1992
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Publication Title |
岡山大学農学部学術報告
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Publication Title Alternative | Scientific Reports of the Faculty of Agriculture Okayama University
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Volume | volume79
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Issue | issue1
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Publisher | 岡山大学農学部
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Publisher Alternative | Faculty of Agriculture, Okayama University
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Start Page | 1
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End Page | 35
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ISSN | 0474-0254
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NCID | AN00033029
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Content Type |
Departmental Bulletin Paper
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language |
English
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File Version | publisher
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Refereed |
False
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Eprints Journal Name | srfa
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