| ID | 58207 |
| FullText URL | |
| Author |
Kobayashi, Terumasa
Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Maruyama, Takayuki
Center for Innovative Clinical Medicine, Okayama University Hospital
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Yoneda, Toshiki
Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Miyai, Hisataka
Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Azuma, Tetsuji
Department of Community Oral Health, Asahi University School of Dentistry
Tomofuji, Takaaki
Department of Community Oral Health, Asahi University School of Dentistry
Ekuni, Daisuke
Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
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Morita, Manabu
Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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| Abstract | Background/aim: The purpose of this study was to determine the anti-aging effects of coffee intake on oxidative stress in rat periodontal tissue and alveolar bone loss.
Materials and methods: Male Fischer 344 rats (8 weeks old) were randomized to four groups; the baseline group immediately sacrificed, the control group fed with normal powdered food for 8 weeks, and the experimental groups fed with powdered food containing 0.62% or 1.36% coffee components for 8 weeks. Results: Alveolar bone loss and gingival level of 8-hydroxydeoxyguanosine were significantly lower in the 1.36% coffee group than in the control group. Nuclear factor erythroid 2-related factor 2 translocation to the nucleus was significantly higher in the 1.36% coffee group than in the control group. Conclusion: Continuous intake of 1.36% coffee could prevent age-related oxidative stress in the periodontal tissue and alveolar bone loss, possibly by up-regulating the Nrf2 signaling pathway. |
| Keywords | Aging
antioxidant
coffee
oxidative stress
periodontal tissue
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| Published Date | 2020-03
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| Publication Title |
In Vivo
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| Volume | volume34
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| Issue | issue2
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| Publisher | International Institute of Anticancer Research
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| Start Page | 615
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| End Page | 622
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| ISSN | 0258-851X
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| Content Type |
Journal Article
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| language |
English
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| OAI-PMH Set |
岡山大学
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| Copyright Holders | Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios)
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| File Version | publisher
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| PubMed ID | |
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| Related Url | isVersionOf https://doi.org/10.21873/invivo.11815
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| Citation | Terumasa Kobayashi, Takayuki Maruyama, Toshiki Yoneda, Hisataka Miyai, Tetsuji Azuma, Takaaki Tomofuji, Daisuke Ekuni, Manabu MoritaIn Vivo 34(2): 615-622, 2020. PMID: 32111761. DOI: 10.21873/invivo.11815
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