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ID 60100
Author
Miyazaki, Ikuko Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
Kikuoka, Ryo Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Isooka, Nami Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Takeshima, Mika Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Sonobe, Kanau Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Arai, Rei Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Funakoshi, Hidemaru Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Quin, Kyle E. Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Smart, Smart Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Zensho, Kazumasa Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Asanuma, Masato Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Kaken ID publons researchmap
Abstract
Bisphenol A diglycidyl ether (BADGE) is an epoxy resin used for the inner coating of canned food and beverages. BADGE can easily migrate from the containers and become a contaminant. In this study, we examined the effects of BADGE exposure to the dams on the behavioral, structural, and developmental abnormalities in the offspring. Female pregnant mice were fed with a diet containing BADGE (0.15 or 1.5 mg/kg/day) during gestation and lactation periods. In an open field test, the time spent in the corner area significantly increases in male mice of high-dose BADGE group at 5 weeks old. The histological analysis using offspring brain at postnatal day 1 delivered from BADGE (1.5 mg/kg/day)-treated dams demonstrates that positive signals of Forkhead box P2- and COUP-TF interacting protein 2 are restricted in each cortical layer, but not in the control brain. In addition, the maternal BADGE exposure reduces nestin-positive fibers of the radial glia and T-box transcription factor 2-positive intermediate progenitors in the inner subventricular zone. Furthermore, a direct BADGE exposure promotes neurite outgrowth and neuronal connection in the primary cultured cortical neurons. These data suggest that maternal BADGE exposure can accelerate neuronal differentiation in fetuses and induce anxiety-like behavior in juvenile mice.
Keywords
Bisphenol A diglycidyl ether
Epoxy resin
Brain development
Neuronal differentiation
Anxiety behavior
Note
This fulltext is available in March 2021.
Published Date
2020-03-03
Publication Title
Food and Chemical Toxicology
Volume
volume138
Publisher
Pergamon
Start Page
111235
ISSN
0278-6915
NCID
AA10627174
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© 2020 Elsevier Ltd.
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DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1016/j.fct.2020.111235
License
https://creativecommons.org/licenses/by-nc-nd/4.0/