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ID 52811
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Author
Dan, Kazuhiro
Ueeda, Masayuki
Ohtsuka, Hiroaki
Ugawa, Satoko
Ohnishi, Nobuhiko
Takaishi, Atsushi
Kusano, Kengo
Abstract
Background: Renal insufficiency plays a critical role in the pathogenesis of ischemic heart disease. The aim of the present study was to investigate the prevalence of renal dysfunction and its impact on prognosis in patients with left main coronary artery disease (LMCAD) and stable angina pectoris. Methods and Results: A total of 626 consecutive patients with significant coronary artery stenosis were enrolled. Renal insufficiency was graded using estimated glomerular filtration rate (eGFR) before coronary angiography. Chronic kidney disease (CKD) was defined as eGFR <60 ml.min(-1) 1.73 m(-2) and/or proteinuria. Patients with LMCAD (n=95) had a significantly higher prevalence of CKD than those without LMCAD (P=0.02). Multiple logistic regression analysis showed that CKD was independently associated with LMCAD (adjusted odds ratio, 1.74; 95% confidence interval [CI]: 1.09-2.76, P=0.01). A 1-year follow-up of patients with LMCAD showed that the cumulative incidence of major adverse cardiovascular events among patients with eGFR <30 ml.min(-1).1.73 m(-2) was higher than that among patients with eGFR >= 60 ml.min(-1).1.73 m(-2) (P=0.03). The hazard ratio for a cardiovascular event was 9.54 (95% CI: 3.15-28.89, P<0.01) when comparing patients with LMCAD and eGFR <30 ml.min(-1).1.73 m(-2) vs. patients without LMCAD and eGFR >= 60 ml.min(-1).1.73 m(-2). Conclusions: Renal insufficiency is a risk factor for LMCAD and predicts poor prognosis in Japanese patients.
Keywords
Chronic kidney disease
Coronary artery disease
Left main coronary artery
Risk factor
Published Date
2012-09
Publication Title
Circulation Journal
Volume
volume76
Issue
issue9
Start Page
2266
End Page
2272
ISSN
1346-9843
Content Type
Journal Article
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/52537
language
英語
Copyright Holders
© 2012 THE JAPANESE CIRCULATION SOCIETY
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Refereed
True
DOI
Web of Sience KeyUT