start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=1
article-no=
start-page=15
end-page=22
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20031225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A study on the scattering exposure dose in radiotherapy.
kn-title=放射線治療時の治療患部外散乱被曝線量に関する研究
en-subtitle=
kn-subtitle=
en-abstract=In modern medicine, radiotherapy has proved indispensable in the treatment of cancer. However. radiation exposure is a health hazard. and is thus strictly regulated. In the past, incidental exposure was not considered to pose a considerable risk, and because radiotherapy was an effective treatment for cancer and because the possibility of the long-term survival was generally poor, the prevalence of radiation injury was thought to be low. In recent years, however, more patients are making complete recoveries, and it is believed that long-term survival is possible with future radiotherapy techniques. There is no threshold for the stochastic effects of radiation exposure, and thus such effects may be detected even at low levels. In the present study, we measured the radiation exposure due to scattered rays from the patient, incidental radiation levels in the radiotherapy room, and levels of neutron radiation. which is a problem when high-energy X-ray radiotherapy systems are used. The results showed that exposure due to scattered rays and incidental levels in the radiotherapy room cannot be dismissed. and that further investigation is warranted. As for neutron radiation, dosages were below those that are known to influence the human body, but regular measurement is necessary because it may induce radioactivity in otherwise benign equipment. In addition, a protective apron had no effect on the exposure due to scattered rays in the radiotherapy room.
kn-abstract=現代の医療のなかで癌治療において不可欠な存在となった放射線治療｡一方,放射線被曝はたとえわずかであってもリスクが伴い,厳しく規制されている｡ただし医療被曝はこの限りになく,過去においては癌患者に放射線治療をおこなう際の患部以外の被曝についてはあまり問題視されなかった｡これには癌の治療という前提に加え,長期生存の可能性が低く,存命中に晩発障害が発生することが低いと考えられていたからである｡しかし,集学的治療が確立した今後の放射線治療においては完治する放射線治療患者が多くなり,治癒後の余命が長くなることが予測される｡放射線被曝による確率的影響は閾値がなく,影響は当然現れるであろう｡そこで,放射線治療をおこなう際の患者の散乱線被曝線量,治療室内散乱線量,さらに高エネルギー放射線発生装置を取り扱うときに問題となっている中性子を測定した｡その結果,測定線量は治療患部外被曝,室内散乱線量ともに無視できない量であることがわかった｡中性子については,人体に影響がある線量は検出されなかったが,中性子の存在は室内物品の放射化の可能性を示唆するもので定期的な測定管理が必要である｡また,]線撮影室用の防護衣による散乱線被曝の低減効果は放射線治療室では無意味であった｡
en-copyright=
kn-copyright=
en-aut-name=KawabeAtsushi
en-aut-sei=Kawabe
en-aut-mei=Atsushi
kn-aut-name=川辺睦
kn-aut-sei=川辺
kn-aut-mei=睦
aut-affil-num=1
ORCID=
en-aut-name=NakagiriYoshitada
en-aut-sei=Nakagiri
en-aut-mei=Yoshitada
kn-aut-name=中桐義忠
kn-aut-sei=中桐
kn-aut-mei=義忠
aut-affil-num=2
ORCID=
en-aut-name=KobashiKazuki
en-aut-sei=Kobashi
en-aut-mei=Kazuki
kn-aut-name=小橋一輝
kn-aut-sei=小橋
kn-aut-mei=一輝
aut-affil-num=3
ORCID=
en-aut-name=YasumuraNaoki
en-aut-sei=Yasumura
en-aut-mei=Naoki
kn-aut-name=安村直樹
kn-aut-sei=安村
kn-aut-mei=直樹
aut-affil-num=4
ORCID=
en-aut-name=YamashitaTakahiro
en-aut-sei=Yamashita
en-aut-mei=Takahiro
kn-aut-name=山下剛央
kn-aut-sei=山下
kn-aut-mei=剛央
aut-affil-num=5
ORCID=
en-aut-name=GotoSachiko
en-aut-sei=Goto
en-aut-mei=Sachiko
kn-aut-name=後藤佐知子
kn-aut-sei=後藤
kn-aut-mei=佐知子
aut-affil-num=6
ORCID=
en-aut-name=MaruyamaToshinori
en-aut-sei=Maruyama
en-aut-mei=Toshinori
kn-aut-name=丸山敏則
kn-aut-sei=丸山
kn-aut-mei=敏則
aut-affil-num=7
ORCID=
en-aut-name=ShibuyaKouichi
en-aut-sei=Shibuya
en-aut-mei=Kouichi
kn-aut-name=澁谷光一
kn-aut-sei=澁谷
kn-aut-mei=光一
aut-affil-num=8
ORCID=
en-aut-name=SugitaKatsuhiko
en-aut-sei=Sugita
en-aut-mei=Katsuhiko
kn-aut-name=杉田勝彦
kn-aut-sei=杉田
kn-aut-mei=勝彦
aut-affil-num=9
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院保健学研究科保健学専攻修士課程
affil-num=2
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
affil-num=3
en-affil=
kn-affil=兵庫県立淡路病院
affil-num=4
en-affil=
kn-affil=津山中央病院
affil-num=5
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻第一期生
affil-num=6
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
affil-num=7
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
affil-num=8
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
affil-num=9
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
en-keyword=散乱線被曝 (Exposure of scattered rays)
kn-keyword=散乱線被曝 (Exposure of scattered rays)
en-keyword=中性子 (Neutron)
kn-keyword=中性子 (Neutron)
en-keyword=放射線治療 (Radiotherapy)
kn-keyword=放射線治療 (Radiotherapy)
en-keyword=確率的影響 (Stochastic effect)
kn-keyword=確率的影響 (Stochastic effect)
END
start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=14
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20031225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Recent trend of research on the nongenotoxic mechanisms of chemical carcinogenesis
kn-title=化学発がんの非遺伝毒性的メカニズムの解明に関する最近の動向
en-subtitle=
kn-subtitle=
en-abstract=To elucidate the health effects by low dose radiation, we reviewed the recent trend of research on the epigenetic mechanisms of chemical carcinogenesis. The following view were obtained. It has become apparent that chemical and physical agents that induce cancer may do so through different cellular and molecular mechanisms. Investigators, recognizing the apparent differences in the ways compounds
participate in the carcinogenesis process, coined the phrases "genotoxic" and "epigenetic" in describing activities of chemicals and physical agents that induced
cancer. The term "nongenotoxic" has to some extent replaced "epigenetic" and thus, classification of chemical carcinogens has been frequently delegated to either the genotoxic or nongenotoxic categories. Moreover, while much work remains in the understanding of the modes and mechanisms of action of nongenotoxic carcinogens and the epigenetic effects of these agents, it is apparent that this category of chemicals are functionally different than those compounds which directly interact, mutate, and modify genomic DNA.
kn-abstract=本総説は,筆者らが進めている｢低線量放射線の健康への影響と医療への応用｣に関する研究に資するために調査した,化学発がんの非遺伝毒性的メカニズムの解明に関する最近の動向の概要についてまとめたものである｡即ち,非遺伝毒性的発がんにおける細胞増殖,シトクロムP450誘導,酸化的ストレス,および遺伝子発現のそれぞれの役割,並びに量的な応答性について言及した｡また,後成的発がんにおけるアポトーシス,およびギャップ結合による情報伝達のそれぞれの役割についても触れた｡その結果,非遺伝毒性的な発がん物質の作用の様式とメカニズムやこれによる後成的な影響などについては解明さ
れつつあり,特に,これらの発がん物質がゲノムDNAに対し直接的な相互作用,突然変異,修飾などを行う発がん物質とは機能的に異なった作用をすることが明らかになった｡また,これらは放射線発がんなど低線量放射線の健康への影響などについて研究する上で,重要な知見となっていることもわかった。
en-copyright=
kn-copyright=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=1
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=花元克巳
kn-aut-sei=花元
kn-aut-mei=克巳
aut-affil-num=2
ORCID=
en-aut-name=InaYasuhiro
en-aut-sei=Ina
en-aut-mei=Yasuhiro
kn-aut-name=稲恭宏
kn-aut-sei=稲
kn-aut-mei=恭宏
aut-affil-num=3
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=片岡隆浩
kn-aut-sei=片岡
kn-aut-mei=隆浩
aut-affil-num=4
ORCID=
en-aut-name=KawabeAtsusi
en-aut-sei=Kawabe
en-aut-mei=Atsusi
kn-aut-name=川辺睦
kn-aut-sei=川辺
kn-aut-mei=睦
aut-affil-num=5
ORCID=
en-aut-name=SanoMasanobu
en-aut-sei=Sano
en-aut-mei=Masanobu
kn-aut-name=佐野正展
kn-aut-sei=佐野
kn-aut-mei=正展
aut-affil-num=6
ORCID=
en-aut-name=UjifukuAyako
en-aut-sei=Ujifuku
en-aut-mei=Ayako
kn-aut-name=氏福亜矢子
kn-aut-sei=氏福
kn-aut-mei=亜矢子
aut-affil-num=7
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
affil-num=2
en-affil=
kn-affil=岡山大学医学部保健学科放射線技術科学専攻
affil-num=3
en-affil=
kn-affil=電力中央研究所低線量放射線研究センター
affil-num=4
en-affil=
kn-affil=岡山大学大学院保健学研究科保健学専攻修士課程
affil-num=5
en-affil=
kn-affil=岡山大学大学院保健学研究科保健学専攻修士課程
affil-num=6
en-affil=
kn-affil=岡山大学大学院保健学研究科保健学専攻修士課程
affil-num=7
en-affil=
kn-affil=岡山大学大学院保健学研究科保健学専攻修士課程
en-keyword=化学発がん (chemical carcinogenesis)
kn-keyword=化学発がん (chemical carcinogenesis)
en-keyword=非遺伝毒性 (nongenotoxicity)
kn-keyword=非遺伝毒性 (nongenotoxicity)
en-keyword=後成説 (epigenesis)
kn-keyword=後成説 (epigenesis)
en-keyword=酸化的ストレス (oxidative stress)
kn-keyword=酸化的ストレス (oxidative stress)
en-keyword=ギャップ結合 (gap junction)
kn-keyword=ギャップ結合 (gap junction)
END
start-ver=1.4
cd-journal=joma
no-vol=61
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=8
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120127
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Basic Study on Positive Effects of Radon Inhalation on Pet's Health
kn-title=ラドン吸入がペットの健康改善に及ぼす効果に関する基礎的検討
en-subtitle=
kn-subtitle=
en-abstract=Radon inhalation using our radon exposure device activated anti-oxidative function in some organs of mouse. To assess the possibility of its application to veterinary care, healthy dogs and cats with chronic renal failure were inhaled radon at a concentration of 5500Bq/m3 for 30 minutes every 2 days for 30 days. In result, radon inhalation within a relatively long time period significantly decreased the triglyceride level of dogs. On the other hand, some cats increased the volume of drinking water by radon inhalation and the creatinine level in blood of these cats was decreased to normal level. These findings suggest that radon inhalation may have curative properties against chronic renal failure.
kn-abstract=著者らは今までに，共同開発したラドン吸入装置を用いマウスにラドン吸入をさせた場合，諸臓器中の抗酸化機能が亢進する可能性などを明らかにしてきた。本研究では，ラドン吸入の獣医療への応用の可能性について新たに検討するため，健常なイヌ5頭(オス：2(1，9才)，メス：3(1〜5才))及び慢性腎不全症のネコ8頭(オス：3(2〜6才)，メス：5(5〜7才))を対象に基礎的な検討をした。すなわち，約5500Bq/m3のラドンを1回30分で隔日に30日間(計15回)それぞれ吸入させた。その結果，イヌにおいて，中性脂肪が減少する可能性が示された。また，その効果は吸入開始20〜30日後に現れることも示唆できた。他方，ネコにおいて，飲水量が改善し血清中クレアチニンが基準値内に減少する症例がみられるなど，慢性腎不全症に対し一定の効果が期待できる可能性が示唆された。
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=片岡隆浩
kn-aut-sei=片岡
kn-aut-mei=隆浩
aut-affil-num=1
ORCID=
en-aut-name=TokunagaRikizo
en-aut-sei=Tokunaga
en-aut-mei=Rikizo
kn-aut-name=徳永力三
kn-aut-sei=徳永
kn-aut-mei=力三
aut-affil-num=2
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=迫田晃弘
kn-aut-sei=迫田
kn-aut-mei=晃弘
aut-affil-num=3
ORCID=
en-aut-name=KawabeAtsushi
en-aut-sei=Kawabe
en-aut-mei=Atsushi
kn-aut-name=川辺睦
kn-aut-sei=川辺
kn-aut-mei=睦
aut-affil-num=4
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=花元克巳
kn-aut-sei=花元
kn-aut-mei=克巳
aut-affil-num=5
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=山岡聖典
kn-aut-sei=山岡
kn-aut-mei=聖典
aut-affil-num=6
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=2
en-affil=
kn-affil=南富士ケンネル附属動物病院
affil-num=3
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=4
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=5
en-affil=
kn-affil=岡山大学大学院保健学研究科
affil-num=6
en-affil=
kn-affil=岡山大学大学院保健学研究科
en-keyword=dog
kn-keyword=dog
en-keyword=cat
kn-keyword=cat
en-keyword=radon inhalation
kn-keyword=radon inhalation
en-keyword=serum biochemistry
kn-keyword=serum biochemistry
en-keyword=chronic renal failure
kn-keyword=chronic renal failure
END
start-ver=1.4
cd-journal=joma
no-vol=146
cd-vols=
no-issue=1-3
article-no=
start-page=360
end-page=363
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=201107
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Studies on possibility for alleviation of lifestyle diseases by low-dose irradiation or radon inhalation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Our previous studies showed the possibility that activation of the antioxidative function alleviates various oxidative damages, which are related to lifestyle diseases. Results showed that, low-dose X-ray irradiation activated superoxide dismutase and inhibits oedema following ischaemia-reperfusion. To alleviate ischaemia-reperfusion injury with transplantation, the changes of the antioxidative function in liver graft using low-dose X-ray irradiation immediately after exenteration were examined. Results showed that liver grafts activate the antioxidative function as a result of irradiation. In addition, radon inhalation enhances the antioxidative function in some organs, and alleviates alcohol-induced oxidative damage of mouse liver. Moreover, in order to determine the most effective condition of radon inhalation, mice inhaled radon before or after carbon tetrachloride (CCl4) administration. Results showed that radon inhalation alleviates CCl4-induced hepatopathy, especially prior inhalation. It is highly possible that adequate activation of antioxidative functions induced by low-dose irradiation can contribute to preventing or reducing oxidative damages, which are related to lifestyle diseases.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=YoshimotoMasaaki
en-aut-sei=Yoshimoto
en-aut-mei=Masaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=NakagawaShinya
en-aut-sei=Nakagawa
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=ToyotaTeruaki
en-aut-sei=Toyota
en-aut-mei=Teruaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=NishiyamaYuichi
en-aut-sei=Nishiyama
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=YamatoKeiko
en-aut-sei=Yamato
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=IshimoriYuu
en-aut-sei=Ishimori
en-aut-mei=Yuu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=KawabeAtsushi
en-aut-sei=Kawabe
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=TaguchiTakehito
en-aut-sei=Taguchi
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=4
en-affil=
kn-affil=Sakakibara Heart Institute of Okayama
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=6
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=7
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=8
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center
affil-num=9
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=10
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=11
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=12
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
END
start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=エアギャップ法代用によるインターベンショナル・ラジオロジー手技中の患者皮膚線量低減
kn-title=Reduction in patient skin dose during Interventional Radiology with the use of an air-gap substitute
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-aut-name=KawabeAtsushi
en-aut-sei=Kawabe
en-aut-mei=Atsushi
kn-aut-name=川辺睦
kn-aut-sei=川辺
kn-aut-mei=睦
aut-affil-num=1
ORCID=
affil-num=1
en-affil=
kn-affil=岡山大学
END
start-ver=1.4
cd-journal=joma
no-vol=43
cd-vols=
no-issue=1
article-no=
start-page=41
end-page=49
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200807
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=No Different Sensitivity in Terms of Whole-Body Irradiation between Normal and Acatalasemic Mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To elucidate the radiosensitivity of an acatalasemic mouse, we examined the time and dose-dependency in the survival rates, the lymphocytes and the intestinal epithelial cells, and the antioxidant function after 3.0 to 12.0 Gy whole body irradiation. Results showed that no significant differences between acatalasemic mice and normal mice were observed in the survival rates and the histological changes in spleens and small intestine after each irradiation. The catalase activities in livers and spleens of acatalasemic mice were significantly lower than those of normal mice and the glutathione peroxidase activity in livers of acatalasemic mice was significantly higher than that of normal mice. At 10 days after 6.0 Gy irradiation, the catalase activities in livers of acatalasemic and normal mice and that in spleens of normal mice significantly decreased compared with no-irradiation control, and there were no differences between those catalase activities. The total glutathione content in acatalasemic mice was significantly higher than that in normal mice at 10 days after 6.0 Gy irradiation. These findings suggested that the radiosensitivity of acatalasemic mice in terms of whole body irradiation doesn’t significantly differ from that of normal mice, probably due to compensated sufficient contents of glutathione peroxidase and total glutathione in acatalasemic mice.
en-copyright=
kn-copyright=
en-aut-name=NakagawaShinya
en-aut-sei=Nakagawa
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=MizuguchiYuko
en-aut-sei=Mizuguchi
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=YoshimotoMasaaki
en-aut-sei=Yoshimoto
en-aut-mei=Masaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=NomuraTakaharu
en-aut-sei=Nomura
en-aut-mei=Takaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=WangDa-Hong
en-aut-sei=Wang
en-aut-mei=Da-Hong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=KawabeAtsushi
en-aut-sei=Kawabe
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=TaguchiTakehito
en-aut-sei=Taguchi
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=4
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=6
en-affil=
kn-affil=Radiation Safety Research Center, Central Research Institute of Electric Power Industry
affil-num=7
en-affil=
kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
affil-num=8
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=9
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=10
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=acatalasemic mouse
kn-keyword=acatalasemic mouse
en-keyword=radiosensitivity
kn-keyword=radiosensitivity
en-keyword=catalase
kn-keyword=catalase
en-keyword=glutathione peroxidase
kn-keyword=glutathione peroxidase
en-keyword=total glutathione
kn-keyword=total glutathione
END
start-ver=1.4
cd-journal=joma
no-vol=34
cd-vols=
no-issue=9
article-no=
start-page=1181
end-page=1187
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Comparative Study on the Inhibitory Effects of α-Tocopherol and Radon on Carbon Tetrachloride-Induced Renal Damage
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Since the 2011 nuclear accident in Fukushima, the effects of low-dose irradiation, especially internal exposure, are at the forefront of everyone’s attention. However, low-dose radiation induced various stimulating effects such as activation of antioxidative and immune functions. In this study, we attempted to evaluate the quantitative effects of the activation of antioxidative activities in kidney induced by radon inhalation on carbon tetrachloride (CCl4)-induced renal damage. Mice were subjected to intraperitoneal (i.p.) injection of CCl4 after inhaling approximately 1000 or 2000 Bq/m3 radon for 24 h, or immediately after i.p. injection of α-tocopherol (100, 300, or 500 mg/kg bodyweight). In case of renal function, radon inhalation at a concentration of 2000 Bq/m3 has the inhibitory effects similar to α-tocopherol treatment at a dose of 300?500 mg/kg bodyweight. The activities of superoxide dismutase and catalase in kidneys were significantly higher in mice exposed to radon as compared to mice treated with CCl4 alone. These findings suggest that radon inhalation has an antioxidative effect against CCl4-induced renal damage similar to the antioxidative effects of α-tocopherol due to induction of antioxidative functions.
en-copyright=
kn-copyright=
en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=YamatoKeiko
en-aut-sei=Yamato
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=NishiyamaYuichi
en-aut-sei=Nishiyama
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=MoriiYuji
en-aut-sei=Morii
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=EtaniReo
en-aut-sei=Etani
en-aut-mei=Reo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=TakataYuji
en-aut-sei=Takata
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
en-aut-name=HanamotoKatsumi
en-aut-sei=Hanamoto
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=
en-aut-name=KawabeAtsuishi
en-aut-sei=Kawabe
en-aut-mei=Atsuishi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=
en-aut-name=SakodaAkihiro
en-aut-sei=Sakoda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=
en-aut-name=IshimoriYuu
en-aut-sei=Ishimori
en-aut-mei=Yuu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=
en-aut-name=TaguchiTakehito
en-aut-sei=Taguchi
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=
en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=
affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=3
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=4
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=5
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=6
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=7
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=8
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=9
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
affil-num=10
en-affil=
kn-affil=Ningyo-toge Environmental Engineering Center, Japan Atomic Energy Agency
affil-num=11
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
affil-num=12
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
en-keyword=radon
kn-keyword=radon
en-keyword=carbon tetrachloride
kn-keyword=carbon tetrachloride
en-keyword=oxidative damage
kn-keyword=oxidative damage
en-keyword=α-tocopherol
kn-keyword=α-tocopherol
en-keyword=kidney
kn-keyword=kidney
END