| FullText URL | K001672.pdf |
|---|---|
| Author | 香川 俊輔| |
| Published Date | 1997-09-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第1672号 |
| Granted Date | 1997-09-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese |
| Title Alternative | In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus |
|---|---|
| FullText URL | 120_01_013_021.pdf |
| Author | Kishimoto, Hiroyuki| Kojima, Toru| Watanabe, Yuichi| Kagawa, Shunsuke| Fujiwara, Toshiya| Uno, Futoshi| Teraishi, Fuminori| Kyo, Satoru| Mizuguchi, Hiroyuki| Hashimoto, Yuuri| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
| Keywords | GFP アデノウイルス ヒトテロメラーゼ逆転写酵素 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2008-05-01 |
| Volume | volume120 |
| Issue | issue1 |
| Start Page | 13 |
| End Page | 21 |
| ISSN | 00301558 |
| language | Japanese |
| Copyright Holders | 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.120.13 |
| NAID | 10024170197 |
| FullText URL | 118_9.pdf |
|---|---|
| Author | 梅岡 達生| 川嶋 健| 香川 俊輔| 寺石 文則| 滝 正樹| 京 哲| 永井 勝幸| 浦田 泰生| 田中 紀章| 藤原 俊義| |
| Keywords | GFP アデノウイルス テロメラーゼ 増幅 遺伝子治療 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2006-05-01 |
| Volume | volume118 |
| Issue | issue1 |
| Start Page | 9 |
| End Page | 15 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright© 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma1947.118.1_9 |
| NAID | 10017417061 |
| Author | Endo, Yoshikatsu| Sakai, Ryo| Ouchi, Masaaki| Onimatsu, Hideki| Hioki, Masayoshi| Kagawa, Shunsuke| Uno, Futoshi| Watanabe, Yuichi| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2008-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Kagawa, Shunsuke| |
|---|---|
| Published Date | 1987-06-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume99 |
| Issue | issue5-6 |
| Content Type | Journal Article |
| Author | Kagawa, Shunsuke| |
|---|---|
| Published Date | 1987-06-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume99 |
| Issue | issue5-6 |
| Content Type | Journal Article |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Umeoka, Tatsuo| Kawashima, Takeshi| Kagawa, Shunsuke| Teraishi, Fuminori| Taki, Masaki| Nishizaki, Masahiko| Kyo, Satoru| Nagai, Katsuyuki| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
| Keywords | GFP adenovirus telomerase replication gene therapy |
| Note | Published with permission from the copyright holder. This is the author's copy, as published in Cancer Research, September 2004, Volume 64, Issue 17, Pages 6259-6265. Copyright © 2004 American Association for Cancer Research. All rights reserved.| |
| Published Date | 2004-09-01 |
| Publication Title | Cancer Research |
| Volume | volume64 |
| Issue | issue17 |
| Publisher | American Association for Cancer Research |
| Start Page | 6259 |
| End Page | 6265 |
| ISSN | 0008-5472 |
| NCID | AA00598557 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | American Association for Cancer Research |
| File Version | author |
| PubMed ID | 15342413 |
| DOI | 10.1158/0008-5472.can-04-1335 |
| Web of Science KeyUT | 000223603200048 |
| Official Url | http://cancerres.aacrjournals.org/content/64/17/6259| |
| Related Url | isVersionOf https://doi.org/10.1158/0008-5472.can-04-1335 |
| Author | Teraishi, Fuminori| Kagawa, Shunsuke| Watanabe, Takanori| Tango, Yasuhisa| Kawashima, Takeshi| Umeoka, Tatsuo| Nisizaki, Masahiko| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2005-08-01 |
| Publication Title | FEBS Letters |
| Volume | volume579 |
| Issue | issue19 |
| Content Type | Journal Article |
| Author | Kojima, Toru| Hashimoto, Yuuri| Kagawa, Shunsuke| Tanaka, Noriaki| Urata, Yasuo| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2010-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume122 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Kuroda, Shinji| Fujiwara, Toshiya| Shirakawa, Yasuhiro| Yamasaki, Yasumoto| Yano, Syuya| Uno, Futoshi| Tazawa, Hiroshi| Hashimoto, Yuuri| Watanabe, Yuichi| Noma, Kazuhiro| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2011-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Sasaki, Tsuyoshi| Tazawa, Hiroshi| Hasei, Jo| Kunisada, Toshiyuki| Yoshida, Aki| Hashimoto, Yuuri| Yano, Shuya| Yoshida, Ryosuke| Uno, Futoshi| Kagawa, Shunsuke| Morimoto, Yuki| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Kojima, Toru| Hashimoto, Yuuri| Watanabe, Yuichi| Kagawa, Shunsuke| Uno, Futoshi| Kuroda, Shinji| Tazawa, Hiroshi| Kyo, Satoru| Mizuguchi, Hiroyuki| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2009-10-01 |
| Publication Title | The Journal of Clinical Investigation |
| Volume | volume119 |
| Issue | issue10 |
| Content Type | Journal Article |
| Author | Kojima, Toru| Watanabe, Yuichi| Hashimoto, Yuuri| Kuroda, Shinji| Yamasaki, Yasumoto| Yano, Shuya| Tazawa, Hiroshi| Uno, Futoshi| Kagawa, Shunsuke| Tanaka, Noriaki| Urata, Yasuo| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Yoshida, Ryosuke| Tazawa, Hiroshi| Hashimoto, Yuuri| Yano, Shuya| Onishi, Teppei| Sasaki, Tsuyoshi| Shirakawa, Yasuhiro| Kishimoto, Hiroyuki| Uno, Futoshi| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2012-11 |
| Publication Title | Cancer Immunology, Immunotherapy |
| Volume | volume61 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Hashimoto, Yuuri| Tazawa, Hiroshi| Teraishi, Fuminori| Kojima, Toru| Watanabe, Yuichi| Uno, Futoshi| Yano, Shuya| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2012-06-15 |
| Publication Title | PLoS ONE |
| Volume | volume7 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Hasei, Joe| Sasaki, Tsuyoshi| Tazawa, Hiroshi| Osaki, Shuhei| Yamakawa, Yasuaki| Kunisada, Toshiyuki| Yoshida, Aki| Hashimoto, Yuuri| Onishi, Teppei| Uno, Futoshi| Kagawa, Shunsuke| Urata, Yasuo| Ozaki, Toshifumi| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-03 |
| Publication Title | Molecular Cancer Therapeutics |
| Volume | volume12 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Tazawa, Hiroshi| Yano, Syuya| Yoshida, Ryosuke| Yamasaki, Yasumoto| Sasaki, Tsuyoshi| Hashimoto, Yuuri| Kuroda, Shinji| Ouchi, Masaaki| Onishi, Teppei| Uno, Futoshi| Kagawa, Syunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-12-02 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue3 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/52006 |
|---|---|
| FullText URL | 67_6_333.pdf |
| Author | Tazawa, Hiroshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of growth factors. On the other hand, infection with pathogenic viruses and bacteria also induces autophagy in infected cells. Oncolytic virotherapy with replication-competent viruses is thus a promising strategy to induce tumor-specific cell death. Oncolytic adenoviruses induce autophagy and subsequently contribute to cell death rather than cell survival in tumor cells. We previously developed a telomerase-specific replication-competent oncolytic adenovirus, OBP-301, which induces cell lysis in tumor cells with telomerase activities. OBP-301-mediated cytopathic activity is significantly associated with induction of autophagy biomarkers. In this review, we focus on the tumor-suppressive role and molecular basis of autophagic machinery induced by oncolytic adenoviruses. Addition of tumor-specific promoters and modification of the fiber knob of adenoviruses supports the oncolytic adenovirus-mediated autophagic cell death. Autophagy is cooperatively regulated by the E1-dependent activation pathway, E4-dependent inhibitory pathway, and microRNA-dependent fine-tuning. Thus, future exploration of the functional role and molecular mechanisms underlying oncolytic adenovirus-induced autophagy would provide novel insights and improve the therapeutic potential of oncolytic adenoviruses. |
| Keywords | oncolytic adenovirus autophagy E2F1 microRNA |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-12 |
| Volume | volume67 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 333 |
| End Page | 342 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24356717 |
| Web of Science KeyUT | 000328915700001 |
| Author | Yano, Shuya| Tazawa, Hiroshi| Hashimoto, Yuuri| Shirakawa, Yasuhiro| Kuroda, Shinji| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Uno, Futoshi| Nagasaka, Takeshi| Urata, Yasuo| Kagawa, Shunsuke| Hoffman, Robert M.| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-12-01 |
| Publication Title | Clinical Cancer Research |
| Volume | volume19 |
| Issue | issue23 |
| Content Type | Journal Article |
| Author | Shigeyasu, Kunitoshi| Tazawa, Hiroshi| Hashimoto, Yuuri| Mori, Yoshiko| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Nagasaka, Takeshi| Kuroda, Shinji| Urata, Yasuo| Goel, Ajay| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2014-05-28 |
| Publication Title | Gut |
| Content Type | Journal Article |
