start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue=1 article-no= start-page=3 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Investigation of SNPs associated with reproductive and body growth traits in Vietnamese and Nepalese native buffaloes en-subtitle= kn-subtitle= en-abstract= kn-abstract=Water buffaloes are essential to the rural economies of many developing countries, including Vietnam and Nepal, but native buffalo populations in these countries face challenges such as low productivity due to fertility and body growth issues. This study analyzed 34 SNPs in 18 genes associated with reproductive and body growth traits reported in cattle and buffalo in Vietnamese and Nepalese native buffaloes. Results showed no polymorphism at bovine SNPs in either buffalo. Further analysis with SNPs previously reported only in popular buffalo breeds, such as Murrah, found that Vietnamese buffalo were monomorphic at all sites, which may reflect reduced genetic diversity due to population decline. In contrast, Nepalese buffalo, consisting of two native breeds, showed polymorphism in 11 SNPs in 7 genes, with 10 of these matching those found in the Murrah buffalo analyzed here. These findings suggest that these SNPs may be applicable for genetic improvement in Nepalese native buffalo. This study provides valuable insights for future conservation and breeding programs aimed at enhancing reproductive and body growth performance of native buffalo in Vietnam and Nepal. en-copyright= kn-copyright= en-aut-name=Thuy ThanhNguyen en-aut-sei=Thuy Thanh en-aut-mei=Nguyen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KuniedaTetsuo en-aut-sei=Kunieda en-aut-mei=Tetsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=Manoj KumarShah en-aut-sei=Manoj Kumar en-aut-mei=Shah kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=Thu Nu AnhLe en-aut-sei=Thu Nu Anh en-aut-mei=Le kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=Van HuuNguyen en-aut-sei=Van Huu en-aut-mei=Nguyen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UshijimaKoichiro en-aut-sei=Ushijima en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NagaeMayuko en-aut-sei=Nagae en-aut-mei=Mayuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TsujiTakehito en-aut-sei=Tsuji en-aut-mei=Takehito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=National Swine Research Program kn-affil= affil-num=4 en-affil=Faculty of Animal Sciences and Veterinary Medicine, University of Agriculture and Forestry, Hue University kn-affil= affil-num=5 en-affil=Faculty of Animal Sciences and Veterinary Medicine, University of Agriculture and Forestry, Hue University kn-affil= affil-num=6 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=7 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=8 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=Vietnamese native buffalo kn-keyword=Vietnamese native buffalo en-keyword=Nepalese native buffalo kn-keyword=Nepalese native buffalo en-keyword=SNPs kn-keyword=SNPs en-keyword=Reproduction kn-keyword=Reproduction en-keyword=Body growth kn-keyword=Body growth END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=1 article-no= start-page=8954 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230602 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Refining the evolutionary tree of the horse Y chromosome en-subtitle= kn-subtitle= en-abstract= kn-abstract=The Y chromosome carries information about the demography of paternal lineages, and thus, can prove invaluable for retracing both the evolutionary trajectory of wild animals and the breeding history of domesticates. In horses, the Y chromosome shows a limited, but highly informative, sequence diversity, supporting the increasing breeding influence of Oriental lineages during the last 1500 years. Here, we augment the primary horse Y-phylogeny, which is currently mainly based on modern horse breeds of economic interest, with haplotypes (HT) segregating in remote horse populations around the world. We analyze target enriched sequencing data of 5 Mb of the Y chromosome from 76 domestic males, together with 89 whole genome sequenced domestic males and five Przewalski's horses from previous studies. The resulting phylogeny comprises 153 HTs defined by 2966 variants and offers unprecedented resolution into the history of horse paternal lineages. It reveals the presence of a remarkable number of previously unknown haplogroups in Mongolian horses and insular populations. Phylogenetic placement of HTs retrieved from 163 archaeological specimens further indicates that most of the present-day Y-chromosomal variation evolved after the domestication process that started around 4200 years ago in the Western Eurasian steppes. Our comprehensive phylogeny significantly reduces ascertainment bias and constitutes a robust evolutionary framework for analyzing horse population dynamics and diversity. en-copyright= kn-copyright= en-aut-name=BozlakElif en-aut-sei=Bozlak en-aut-mei=Elif kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=RadovicLara en-aut-sei=Radovic en-aut-mei=Lara kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=RemerViktoria en-aut-sei=Remer en-aut-mei=Viktoria kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=RiglerDoris en-aut-sei=Rigler en-aut-mei=Doris kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AllenLucy en-aut-sei=Allen en-aut-mei=Lucy kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=BremGottfried en-aut-sei=Brem en-aut-mei=Gottfried kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=StalderGabrielle en-aut-sei=Stalder en-aut-mei=Gabrielle kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=CastanedaCaitlin en-aut-sei=Castaneda en-aut-mei=Caitlin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=CothranGus en-aut-sei=Cothran en-aut-mei=Gus kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=RaudseppTerje en-aut-sei=Raudsepp en-aut-mei=Terje kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=OkudaYu en-aut-sei=Okuda en-aut-mei=Yu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MoeKyaw Kyaw en-aut-sei=Moe en-aut-mei=Kyaw Kyaw kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=MoeHla Hla en-aut-sei=Moe en-aut-mei=Hla Hla kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KounnavongsaBounthavone en-aut-sei=Kounnavongsa en-aut-mei=Bounthavone kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=KeonouchanhSoukanh en-aut-sei=Keonouchanh en-aut-mei=Soukanh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=VanNguyen Huu en-aut-sei=Van en-aut-mei=Nguyen Huu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=VuVan Hai en-aut-sei=Vu en-aut-mei=Van Hai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=ShahManoj Kumar en-aut-sei=Shah en-aut-mei=Manoj Kumar kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=NishiboriMasahide en-aut-sei=Nishibori en-aut-mei=Masahide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=KazymbetPolat en-aut-sei=Kazymbet en-aut-mei=Polat kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=BakhtinMeirat en-aut-sei=Bakhtin en-aut-mei=Meirat kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=ZhunushovAsankadyr en-aut-sei=Zhunushov en-aut-mei=Asankadyr kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= en-aut-name=PaulRipon Chandra en-aut-sei=Paul en-aut-mei=Ripon Chandra kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=23 ORCID= en-aut-name=DashnyamBumbein en-aut-sei=Dashnyam en-aut-mei=Bumbein kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=24 ORCID= en-aut-name=NozawaKen en-aut-sei=Nozawa en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=25 ORCID= en-aut-name=AlmarzookSaria en-aut-sei=Almarzook en-aut-mei=Saria kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=26 ORCID= en-aut-name=BrockmannGudrun A. en-aut-sei=Brockmann en-aut-mei=Gudrun A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=27 ORCID= en-aut-name=ReissmannMonika en-aut-sei=Reissmann en-aut-mei=Monika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=28 ORCID= en-aut-name=AntczakDouglas F. en-aut-sei=Antczak en-aut-mei=Douglas F. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=29 ORCID= en-aut-name=MillerDonald C. en-aut-sei=Miller en-aut-mei=Donald C. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=30 ORCID= en-aut-name=SadeghiRaheleh en-aut-sei=Sadeghi en-aut-mei=Raheleh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=31 ORCID= en-aut-name=Butler-WemkenInes von en-aut-sei=Butler-Wemken en-aut-mei=Ines von kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=32 ORCID= en-aut-name=KostarasNikos en-aut-sei=Kostaras en-aut-mei=Nikos kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=33 ORCID= en-aut-name=HanHaige en-aut-sei=Han en-aut-mei=Haige kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=34 ORCID= en-aut-name=ManglaiDugarjaviin en-aut-sei=Manglai en-aut-mei=Dugarjaviin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=35 ORCID= en-aut-name=AbdurasulovAbdugani en-aut-sei=Abdurasulov en-aut-mei=Abdugani kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=36 ORCID= en-aut-name=SukhbaatarBoldbaatar en-aut-sei=Sukhbaatar en-aut-mei=Boldbaatar kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=37 ORCID= en-aut-name=Ropka-MolikKatarzyna en-aut-sei=Ropka-Molik en-aut-mei=Katarzyna kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=38 ORCID= en-aut-name=Stefaniuk-SzmukierMonika en-aut-sei=Stefaniuk-Szmukier en-aut-mei=Monika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=39 ORCID= en-aut-name=LopesMaria Susana en-aut-sei=Lopes en-aut-mei=Maria Susana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=40 ORCID= en-aut-name=MachadoArtur da C?mara en-aut-sei=Machado en-aut-mei=Artur da C?mara kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=41 ORCID= en-aut-name=KalashnikovValery V. en-aut-sei=Kalashnikov en-aut-mei=Valery V. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=42 ORCID= en-aut-name=KalinkovaLiliya en-aut-sei=Kalinkova en-aut-mei=Liliya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=43 ORCID= en-aut-name=ZaitevAlexander M. en-aut-sei=Zaitev en-aut-mei=Alexander M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=44 ORCID= en-aut-name=Novoa-BravoMiguel en-aut-sei=Novoa-Bravo en-aut-mei=Miguel kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=45 ORCID= en-aut-name=LindgrenGabriella en-aut-sei=Lindgren en-aut-mei=Gabriella kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=46 ORCID= en-aut-name=BrooksSamantha en-aut-sei=Brooks en-aut-mei=Samantha kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=47 ORCID= en-aut-name=RosaLaura Patterson en-aut-sei=Rosa en-aut-mei=Laura Patterson kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=48 ORCID= en-aut-name=OrlandoLudovic en-aut-sei=Orlando en-aut-mei=Ludovic kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=49 ORCID= en-aut-name=JurasRytis en-aut-sei=Juras en-aut-mei=Rytis kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=50 ORCID= en-aut-name=KuniedaTetsuo en-aut-sei=Kunieda en-aut-mei=Tetsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=51 ORCID= en-aut-name=WallnerBarbara en-aut-sei=Wallner en-aut-mei=Barbara kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=52 ORCID= affil-num=1 en-affil=Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna kn-affil= affil-num=2 en-affil=Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna kn-affil= affil-num=3 en-affil=Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna kn-affil= affil-num=4 en-affil=Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna kn-affil= affil-num=5 en-affil=Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna kn-affil= affil-num=6 en-affil=Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna kn-affil= affil-num=7 en-affil=Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna kn-affil= affil-num=8 en-affil=School of Veterinary Medicine and Biomedical Sciences, Texas A&M University kn-affil= affil-num=9 en-affil=School of Veterinary Medicine and Biomedical Sciences, Texas A&M University kn-affil= affil-num=10 en-affil=School of Veterinary Medicine and Biomedical Sciences, Texas A&M University kn-affil= affil-num=11 en-affil=Museum of Dinosaur Research, Okayama University of Science kn-affil= affil-num=12 en-affil=Department of Pathology and Microbiology, University of Veterinary Science kn-affil= affil-num=13 en-affil=Department of Genetics and Animal Breeding, University of Veterinary Science kn-affil= affil-num=14 en-affil=National Agriculture and Forestry Research Institute (Lao) Resources, Livestock Research Center kn-affil= affil-num=15 en-affil=Faculty of Animal Science and Veterinary Medicine, University of Agriculture and Forestry, Hue University kn-affil= affil-num=16 en-affil=Faculty of Animal Science and Veterinary Medicine, University of Agriculture and Forestry, Hue University kn-affil= affil-num=17 en-affil=Faculty of Animal Science and Veterinary Medicine, University of Agriculture and Forestry, Hue University kn-affil= affil-num=18 en-affil=Faculty of Animal Science, Veterinary Science and Fisheries, Agriculture and Forestry University kn-affil= affil-num=19 en-affil=Graduate School of Integrated Sciences for Life, Hiroshima University kn-affil= affil-num=20 en-affil=Radiobiological Research Institute, JSC Astana Medical University kn-affil= affil-num=21 en-affil=Institute of Biotechnology, National Academy of Sciences of the Kyrgyz Republic kn-affil= affil-num=22 en-affil=Institute of Biotechnology, National Academy of Sciences of the Kyrgyz Republic kn-affil= affil-num=23 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=24 en-affil=Institute of Biological Sciences, Mongolian Academy of Sciences kn-affil= affil-num=25 en-affil=Primate Research Institute, Kyoto University kn-affil= affil-num=26 en-affil=Albrecht Daniel Thaer?Institut, Humboldt-Universit?t zu Berlin kn-affil= affil-num=27 en-affil=Albrecht Daniel Thaer?Institut, Humboldt-Universit?t zu Berlin kn-affil= affil-num=28 en-affil=Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University kn-affil= affil-num=29 en-affil=Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University kn-affil= affil-num=30 en-affil=Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University kn-affil= affil-num=31 en-affil=Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University kn-affil= affil-num=32 en-affil=Barb Horse Breeding Organisation VFZB E. V., Verein der Freunde und Z?chter Des Berberpferdes E.V. kn-affil= affil-num=33 en-affil=Amaltheia kn-affil= affil-num=34 en-affil=Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, College of Animal Science, Equine Research Center, Inner Mongolia Agricultural University kn-affil= affil-num=35 en-affil=Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, College of Animal Science, Equine Research Center, Inner Mongolia Agricultural University kn-affil= affil-num=36 en-affil=Department of Agriculture, Faculty of Natural Sciences and Geography, Osh State University kn-affil= affil-num=37 en-affil=Sector of Surveillance and Diagnosis of Infectious Diseases, State Central Veterinary Laboratory kn-affil= affil-num=38 en-affil=National Research Institute of Animal Production, Animal Molecular Biology kn-affil= affil-num=39 en-affil=National Research Institute of Animal Production, Animal Molecular Biology kn-affil= affil-num=40 en-affil=Biotechnology Centre of Azores, University of Azores kn-affil= affil-num=41 en-affil=Biotechnology Centre of Azores, University of Azores kn-affil= affil-num=42 en-affil=All-Russian Research Institute for Horse Breeding kn-affil= affil-num=43 en-affil=All-Russian Research Institute for Horse Breeding kn-affil= affil-num=44 en-affil=All-Russian Research Institute for Horse Breeding kn-affil= affil-num=45 en-affil=Gen?tica Animal de Colombia SAS. kn-affil= affil-num=46 en-affil=Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences kn-affil= affil-num=47 en-affil=Department of Animal Science, UF Genetics Institute, University of Florida kn-affil= affil-num=48 en-affil=Department of Agriculture and Industry, Sul Ross State University kn-affil= affil-num=49 en-affil=Centre d’Anthropobiologie et de G?nomique de Toulouse, Universit? Paul Sabatier kn-affil= affil-num=50 en-affil=School of Veterinary Medicine and Biomedical Sciences, Texas A&M University kn-affil= affil-num=51 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=52 en-affil=Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna kn-affil= END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue= article-no= start-page=1 end-page=1 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=201804 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=会長あいさつ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KuniedaTetsuo en-aut-sei=Kunieda en-aut-mei=Tetsuo kn-aut-name=国枝哲夫 kn-aut-sei=国枝 kn-aut-mei=哲夫 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil=岡山大学大学院環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue= article-no= start-page=1 end-page=1 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=201704 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A greeting from President of Okayama Association for Laboratory Animal Science kn-title=会長あいさつ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KuniedaTetsuo en-aut-sei=Kunieda en-aut-mei=Tetsuo kn-aut-name=国枝哲夫 kn-aut-sei=国枝 kn-aut-mei=哲夫 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil=環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue= article-no= start-page=1 end-page=1 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=201604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Agreeting from President of Okayama Association for Laboratory Animal science kn-title=会長あいさつ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KuniedaTetsuo en-aut-sei=Kunieda en-aut-mei=Tetsuo kn-aut-name=国枝哲夫 kn-aut-sei=国枝 kn-aut-mei=哲夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol=85 cd-vols= no-issue=1 article-no= start-page=89 end-page=98 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Molecular Genetics of Mammals kn-title=哺乳類の分子遺伝学 en-subtitle= kn-subtitle= en-abstract=近年の分子生物学の発展は、ヒトを含む哺乳類の遺伝学にも大きな変化をもたらしている。すなわち、表現型を主な対象とした従来の遺伝学から、DNAをはじめとする分子を対象とした遺伝学へとその中心は移行しつつある。この傾向に拍車をかけたのがここ数年話題になることの多いヒトゲノムプロジェクトであり、またヒトの遺伝病の原因遺伝子の解析と遺伝子診断、遺伝子治療の進展である。農学や畜産学の分野でも、分子育種という概念が確立しつつあり、本論文ではヒト、家畜および実験動物を対象とした哺乳類の分子遺伝学の最近の動向について、我々の研究結果を含めて概説したい。 kn-abstract=Recent advances in molecular genetics of mammals,including construction of genetic linkage maps, identification of mutations responsible for inheritable diseases, mapping of quantitative trait loci,and findings about sex determination are reviewed in the present paper. Information about genomes of humans,laboratory animals and domestic animals has been rapidly accumulated in the last decade. Establishment of polymorphic linkage markers and construction of chromosomal linkage maps of mammalian species enable us to identify the genes responsible for particular genetic traits. Various mutations have been found in genes responsible for human inheritable diseases. We have constructed genetic linkage maps for rats and identified a mutation responsible for mucopoly saccharidosis in rats. Mapping of loci affecting the quantitative traits of domestic animals, including growth rate, litter size, and milk production, as well as identification of the genes responsible for inheritable diseases of domestic animals, are also being carried out.Recently, the testis-determining gene on the Y chromosome, which determine the sex of mammals by defferentiating the testis in the embryos, have been identified in humans and mice. Functions of the sex-determining gene in sexual differentiation of the mammalian embryos have been intensively analyzed. We have found a sexual difference in the growth rate of mouse preimplantation embryos. An application of the recent findings in the molecular genetics of mammals will contribute to animal science and agricultural science. en-copyright= kn-copyright= en-aut-name=KuniedaTetsuo en-aut-sei=Kunieda en-aut-mei=Tetsuo kn-aut-name=国枝哲夫 kn-aut-sei=国枝 kn-aut-mei=哲夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=chromosome mapping kn-keyword=chromosome mapping en-keyword=linkage kn-keyword=linkage en-keyword=inheritable disease kn-keyword=inheritable disease en-keyword=sex determination kn-keyword=sex determination END