ID | 46941 |
FullText URL | |
Author |
Takahashi, Akiko
Sisido, Masahiko
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Abstract | We synthesized 16 pyrrolidine-based oxy-peptide nucleic acid (POPNA) monomers carrying four different nucleobases onto four different stereoisomers of pyrrolidine rings. Using these monomers, we prepared POPNA oligomers, which formed sequence-specific hybrids with DNAs. The oligomer configurations influenced the hybrid stability. The oligomers were not taken into CHO cells. However, they could enter the cell cytoplasm when mixed with the influenza virus hemagglutinin peptide-arginine heptamer conjugate.
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Keywords | Peptide nucleic acid
Solid-phase peptide synthesis
Cell-penetrating peptide
Confocal laser scanning microscopy
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Published Date | 2010-12-18
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Publication Title |
Tetrahedron
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Volume | volume66
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Issue | issue51
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Publisher | Pergamon-Elsevier Science Ltd.
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Start Page | 9659
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End Page | 9666
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ISSN | 0040-4020
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NCID | AA00861787
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Content Type |
Journal Article
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language |
English
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Copyright Holders | © 2010 Elsevier Ltd. All rights reserved.
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File Version | author
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Refereed |
True
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DOI | |
Web of Science KeyUT |