ID | 62276 |
FullText URL | |
Author |
Hirooka, Asuka
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Hamada, Mayuko
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Fujiyama, Daiki
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Takanami, Keiko
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Kobayashi, Yasuhisa
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Oti, Takumi
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Katayama, Yukitoshi
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
Kaken ID
researchmap
Sakamoto, Tatsuya
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
ORCID
Kaken ID
publons
researchmap
Sakamoto, Hirotaka
Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
ORCID
Kaken ID
publons
researchmap
|
Abstract | Bombesin is a putative antibacterial peptide isolated from the skin of the frog, Bombina bombina. Two related (bombesin-like) peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB) have been found in mammals. The history of GRP/bombesin discovery has caused little attention to be paid to the evolutionary relationship of GRP/bombesin and their receptors in vertebrates. We have classified the peptides and their receptors from the phylogenetic viewpoint using a newly established genetic database and bioinformatics. Here we show, by using a clawed frog (Xenopus tropicalis), that GRP is not a mammalian counterpart of bombesin and also that, whereas the GRP system is widely conserved among vertebrates, the NMB/bombesin system has diversified in certain lineages, in particular in frog species. To understand the derivation of GRP system in the ancestor of mammals, we have focused on the GRP system in Xenopus. Gene expression analyses combined with immunohistochemistry and Western blotting experiments demonstrated that GRP peptides and their receptors are distributed in the brain and stomach of Xenopus. We conclude that GRP peptides and their receptors have evolved from ancestral (GRP-like peptide) homologues to play multiple roles in both the gut and the brain as one of the 'gut-brain peptide' systems.
|
Published Date | 2021-06-25
|
Publication Title |
Scientific Reports
|
Volume | volume11
|
Issue | issue1
|
Publisher | Nature Research
|
Start Page | 13315
|
ISSN | 2045-2322
|
Content Type |
Journal Article
|
language |
English
|
OAI-PMH Set |
岡山大学
|
Copyright Holders | © The Author(s) 2021
|
File Version | publisher
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
Related Url | isVersionOf https://doi.org/10.1038/s41598-021-92528-x
|
License | http://creativecommons.org/licenses/by/4.0/
|
Funder Name |
Japan Society for the Promotion of Science
Japan Agency for Medical Research and Development (AMED)
Okayama University Dispatch Project for Female Faculty members
|
助成番号 | 15K15202
15KK0257
15H05724
16H06280
961149
8007
21H00428
|