ID | 55446 |
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Author |
Taniguchi, Akihiko
Department of Allergy and Respiratory Medicine, Okayama University Hospital
Kaken ID
Miyahara, Nobuaki
Department of Allergy and Respiratory Medicine, Okayama University Hospital
Oda, Naohiro
Department of Allergy and Respiratory Medicine, Okayama University Hospital
Morichika, Daisuke
Department of Allergy and Respiratory Medicine, Okayama University Hospital
Ichihara, Eiki
Department of Allergy and Respiratory Medicine, Okayama University Hospital
Kaken ID
publons
Oze, Isao
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
Tanimoto, Yasushi
National Hospital Organization Minami-Okayama Medical Center
Ichikawa, Hirohisa
Department of Respiratory Medicine, KKR Takamatsu Hospital
Fujii, Utako
Department of Allergy and Respiratory Medicine, Okayama University Hospital
Tanimoto, Mitsune
Department of Allergy and Respiratory Medicine, Okayama University Hospital
Kaken ID
publons
researchmap
Kanehiro, Arihiko
Department of Allergy and Respiratory Medicine, Okayama University Hospital
Kiura, Katsuyuki
Department of Allergy and Respiratory Medicine, Okayama University Hospital
ORCID
Kaken ID
publons
researchmap
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Abstract | Although recent retrospective studies suggested that the use of β-blockers appears to help improve the mortality rate and decrease the rate of exacerbation in chronic obstructive pulmonary disease (COPD) patients with heart failure, the effects of β-blockers on COPD patients without heart failure have not been established. Based on previous reports, we have launched a multicenter, prospective, single-arm phase II study to evaluate the preventive effect of the cardioselective β-blocker bisoprolol in COPD exacerbation, in Japanese individuals with moderate-to-severe COPD who do not have heart failure but do have hypertension requiring the use of medication. The primary endpoint is the rate of mild-to-severe COPD exacerbation. The results of this study will clarify whether bisoprolol can prevent exacerbation in COPD patients without heart failure.
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Keywords | chronic obstructive pulmonary disease
β-blocker
bisoprolol
exacerbation
heart failure
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Amo Type | Clinical Study Protocol
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Publication Title |
Acta Medica Okayama
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Published Date | 2017-10
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Volume | volume71
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Issue | issue5
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Publisher | Okayama University Medical School
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Start Page | 453
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End Page | 457
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School
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File Version | publisher
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Refereed |
True
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PubMed ID |