start-ver=1.4
cd-journal=joma
no-vol=23
cd-vols=
no-issue=15
article-no=
start-page=8592
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220802
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Fibroblast Growth Factors and Cellular Communication Network Factors: Intimate Interplay by the Founding Members in Cartilage
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Fibroblast growth factors (FGFs) constitute a large family of signaling molecules that act in an autocrine/paracrine, endocrine, or intracrine manner, whereas the cellular communication network factors (CCN) family is composed of six members that manipulate extracellular signaling networks. FGFs and CCNs are structurally and functionally distinct, except for the common characteristics as matricellular proteins. Both play significant roles in the development of a variety of tissues and organs, including the skeletal system. In vertebrates, most of the skeletal parts are formed and grow through a process designated endochondral ossification, in which chondrocytes play the central role. The growth plate cartilage is the place where endochondral ossification occurs, and articular cartilage is left to support the locomotive function of joints. Several FGFs, including FGF-2, one of the founding members of this family, and all of the CCNs represented by CCN2, which is required for proper skeletal development, can be found therein. Research over a decade has revealed direct binding of CCN2 to FGFs and FGF receptors (FGFRs), which occasionally affect the biological outcome via FGF signaling. Moreover, a recent study uncovered an integrated regulation of FGF and CCN genes by FGF signaling. In this review, after a brief introduction of these two families, molecular and genetic interactions between CCN and FGF family members in cartilage, and their biological effects, are summarized. The molecular interplay represents the mutual involvement of the other in their molecular functions, leading to collaboration between CCN2 and FGFs during skeletal development.
en-copyright=
kn-copyright=

en-aut-name=KubotaSatoshi
en-aut-sei=Kubota
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AoyamaEriko
en-aut-sei=Aoyama
en-aut-mei=Eriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakigawaMasaharu
en-aut-sei=Takigawa
en-aut-mei=Masaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NishidaTakashi
en-aut-sei=Nishida
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Biochemistry and Molecular Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Advanced Research Center for Oral and Craniofacial Sciences, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Advanced Research Center for Oral and Craniofacial Sciences, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Biochemistry and Molecular Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=fibroblast growth factor
kn-keyword=fibroblast growth factor
en-keyword=cellular communication network factor
kn-keyword=cellular communication network factor
en-keyword=cartilage
kn-keyword=cartilage
en-keyword=skeletal development
kn-keyword=skeletal development
en-keyword=CCN2
kn-keyword=CCN2
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=
article-no=
start-page=1
end-page=10
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20151230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title="Romeo und Julia" auf der Opernb?hne ― Von Gottfried Keller zu Frederic Delius ―
kn-title=オペラ舞台の『ロメオとユリア』 : ゴットフリート・ケラーからフレデリック・ディーリアスヘ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=互いの家同士の確執を知りながらも愛し合うことになってしまった男女の悲劇を描き出したシェイクスピアの作品のプロットが19 世紀リアリズム期の作家ゴットフリート・ケラーの『村のロメオとユリア』においてもそっくりのまま使い回されたわけでは決してない。現実を見つめるケラーのまなざしは悲劇に至る経緯と背景を丹念に追い求めているのである。しかしながらドイツにルーツを持つイギリス人作曲家フレデリック・ディーリアスがシェイクスピアではなくケラーの小説の方をオペラの題材に選んだ時、音楽家としての感性はリアリズム小説のプロットにさまざまな変更を施すことになる。
en-copyright=
kn-copyright=

en-aut-name=KubotaSatoshi
en-aut-sei=Kubota
en-aut-mei=Satoshi
kn-aut-name=久保田聡
kn-aut-sei=久保田
kn-aut-mei=聡
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学言語教育センター
en-keyword=確執
kn-keyword=確執
en-keyword=リアリズム
kn-keyword=リアリズム
en-keyword=示導動機
kn-keyword=示導動機
en-keyword=「楽園」
kn-keyword=「楽園」
en-keyword=夢
kn-keyword=夢
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=
article-no=
start-page=59
end-page=68
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=201412
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Von Jenseits der Erinnerungen ― Bemerkungen ?ber Theodor Storms "Von heut und ehedem" ―
kn-title=思い出の彼方より ― テオドール・シュトルムの『今と昔』への考察 ―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　本稿は19 世紀ドイツリアリズム期を代表する作家のひとりであるテオドール・シュトル
ム(1817-1888)の作品『今と昔(Von heut und ehedem)』(1873)において、シュトルム自身と考
えられる＜私＞とシュトルムの母方の＜祖母＞の視点から、かつての曾祖父の家や祖父の家
とそこに集まる人々の様子、そしてさらには故郷の町フーズムがどのように描き出されてい
るかについて考察することを目的とする。自らの記憶のもはや届かない＜祖母の過去＞にま
で話を繰り広げる＜私＞からは、失われてしまったものへ哀惜の念を抱き、それを物語の中
で再びよみがえらせようとするシュトルムの姿が見て取れるのである。
en-copyright=
kn-copyright=

en-aut-name=KubotaSatoshi
en-aut-sei=Kubota
en-aut-mei=Satoshi
kn-aut-name=久保田聡
kn-aut-sei=久保田
kn-aut-mei=聡
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学言語教育センター
en-keyword=旅
kn-keyword=旅
en-keyword=思い出
kn-keyword=思い出
en-keyword=風景
kn-keyword=風景
en-keyword=故郷
kn-keyword=故郷
en-keyword=海
kn-keyword=海
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20070331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=奥付
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NagaseHaruo
en-aut-sei=Nagase
en-aut-mei=Haruo
kn-aut-name=永瀬春男
kn-aut-sei=永瀬
kn-aut-mei=春男
aut-affil-num=1
ORCID=

en-aut-name=YamaguchiNobuo
en-aut-sei=Yamaguchi
en-aut-mei=Nobuo
kn-aut-name=山口信夫
kn-aut-sei=山口
kn-aut-mei=信夫
aut-affil-num=2
ORCID=

en-aut-name=KubotaSatoshi
en-aut-sei=Kubota
en-aut-mei=Satoshi
kn-aut-name=久保田聡
kn-aut-sei=久保田
kn-aut-mei=聡
aut-affil-num=3
ORCID=

en-aut-name=YoshidaHiroshi
en-aut-sei=Yoshida
en-aut-mei=Hiroshi
kn-aut-name=吉田浩
kn-aut-sei=吉田
kn-aut-mei=浩
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=
article-no=
start-page=47
end-page=62
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20070331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=〈ヨーロッパ〉への叶わぬ夢 ―ヴィルヘルム・ラーベの『ライラックの花』の作品世界としてのプラハ―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KubotaSatoshi
en-aut-sei=Kubota
en-aut-mei=Satoshi
kn-aut-name=久保田聡
kn-aut-sei=久保田
kn-aut-mei=聡
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20070331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NagaseHaruo
en-aut-sei=Nagase
en-aut-mei=Haruo
kn-aut-name=永瀬春男
kn-aut-sei=永瀬
kn-aut-mei=春男
aut-affil-num=1
ORCID=

en-aut-name=YamaguchiNobuo
en-aut-sei=Yamaguchi
en-aut-mei=Nobuo
kn-aut-name=山口信夫
kn-aut-sei=山口
kn-aut-mei=信夫
aut-affil-num=2
ORCID=

en-aut-name=KubotaSatoshi
en-aut-sei=Kubota
en-aut-mei=Satoshi
kn-aut-name=久保田聡
kn-aut-sei=久保田
kn-aut-mei=聡
aut-affil-num=3
ORCID=

en-aut-name=YoshidaHiroshi
en-aut-sei=Yoshida
en-aut-mei=Hiroshi
kn-aut-name=吉田浩
kn-aut-sei=吉田
kn-aut-mei=浩
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20070331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=刊行に序して
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NagaseHaruo
en-aut-sei=Nagase
en-aut-mei=Haruo
kn-aut-name=永瀬春男
kn-aut-sei=永瀬
kn-aut-mei=春男
aut-affil-num=1
ORCID=

en-aut-name=YamaguchiNobuo
en-aut-sei=Yamaguchi
en-aut-mei=Nobuo
kn-aut-name=山口信夫
kn-aut-sei=山口
kn-aut-mei=信夫
aut-affil-num=2
ORCID=

en-aut-name=KubotaSatoshi
en-aut-sei=Kubota
en-aut-mei=Satoshi
kn-aut-name=久保田聡
kn-aut-sei=久保田
kn-aut-mei=聡
aut-affil-num=3
ORCID=

en-aut-name=YoshidaHiroshi
en-aut-sei=Yoshida
en-aut-mei=Hiroshi
kn-aut-name=吉田浩
kn-aut-sei=吉田
kn-aut-mei=浩
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=
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dt-received=
dt-revised=
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dt-pub-year=2007
dt-pub=20070331
dt-online=
en-article=
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kn-subject=
en-title=
kn-title=表紙
en-subtitle=
kn-subtitle=
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kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NagaseHaruo
en-aut-sei=Nagase
en-aut-mei=Haruo
kn-aut-name=永瀬春男
kn-aut-sei=永瀬
kn-aut-mei=春男
aut-affil-num=1
ORCID=

en-aut-name=YamaguchiNobuo
en-aut-sei=Yamaguchi
en-aut-mei=Nobuo
kn-aut-name=山口信夫
kn-aut-sei=山口
kn-aut-mei=信夫
aut-affil-num=2
ORCID=

en-aut-name=KubotaSatoshi
en-aut-sei=Kubota
en-aut-mei=Satoshi
kn-aut-name=久保田聡
kn-aut-sei=久保田
kn-aut-mei=聡
aut-affil-num=3
ORCID=

en-aut-name=YoshidaHiroshi
en-aut-sei=Yoshida
en-aut-mei=Hiroshi
kn-aut-name=吉田浩
kn-aut-sei=吉田
kn-aut-mei=浩
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=岡山大学
END