JaLCDOI 10.18926/AMO/54808
FullText URL 70_6_455.pdf
Author Tanino, Masaaki| Kobayashi, Motomu| Sasaki, Toshihiro| Takata, Ken| Takeda, Yoshimasa| Mizobuchi, Satoshi| Morita, Kiyoshi| Nagai, Taku| Morimatsu, Hiroshi|
Abstract Postoperative cognitive dysfunction (POCD) occurs in nearly one-third of patients after non-cardiac surgery. Many animal behavior studies have investigated the effect of general anesthesia on cognitive function. However, there have been no studies examining the effects on working memory specifically, with a focus on the retention of working memory. We demonstrate here that isoflurane anesthesia induces deficits in the retention of spatial working memory in rats, as revealed by an increase in isoflurane-induced across-phase errors in the delayed spatial win-shift (SWSh) task with a 30-min delay in an 8-arm radial arm maze on post-anesthesia days (PADs) 1,2,4, and 10. A post-hoc analysis revealed a significant increase in across-phase errors on PAD 1 and recovery on PAD 10 in the isoflurane group. In contrast, within-phase errors independent of the retention of working memory were unaffected by isoflurane. These results demonstrate that isoflurane anesthesia transiently impairs the retention of spatial working memory in rats.
Keywords postoperative cognitive dysfunction isoflurane spatial working memory retention delayed spatial win-shift task
Amo Type Original Article
Published Date 2016-12
Publication Title Acta Medica Okayama
Volume volume70
Issue issue6
Publisher Okayama University Medical School
Start Page 455
End Page 460
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28003670
FullText URL ST49_3_254.pdf
Author Sugimoto, Seiichiro| Kurosaki, Takeshi| Otani, Shinji| Tanaka, Shin| Hikasa, Yukiko| Yamane, Masaomi| Toyooka, Shinichi| Kobayashi, Motomu| Oto, Takahiro|
Keywords Brain-dead donor Extended-criteria donor Lung transplantation Marginal donor Mechanical ventilation
Published Date 2018-10-27
Publication Title Surgery Today
Volume volume49
Issue issue3
Publisher Springer
Start Page 254
End Page 260
ISSN 0941-1291
NCID AA10824685
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30368607
DOI 10.1007/s00595-018-1730-z
Web of Science KeyUT 000462246600010
Related Url isVersionOf https://doi.org/10.1007/s00595-018-1730-z
JaLCDOI 10.18926/AMO/57721
FullText URL 73_6_543.pdf
Author Kubo, Asuka| Shimizu, Kazuyoshi| Kuroda, Kosuke| Kanazawa, Tomoyuki| Kobayashi, Motomu| Morimatsu, Hiroshi|
Abstract We here report that a 71-year-old Japanese woman with a history of anaphylaxis induced by muscle relaxants had local anesthetic systemic toxicity (LAST) following an abdominal surgery under general anesthesia with combined spinal-epidural anesthesia without muscle relaxants. The total dosages of local anesthetics reached 0.67 mg/kg of ropivacaine and 11.5 mg/kg of lidocaine over 12.5 h to obtain sufficient muscle relaxation for surgery. Regional anesthesia is useful in cases in which muscle relaxants are to be avoided during a surgery. However, especially for a patient with risk factors and prolonged surgery, precautions should be taken to prevent LAST.
Keywords muscle relaxant-induced anaphylaxis local anesthetic systemic toxicity epidural anesthesia abdominal surgery
Amo Type Case Report
Published Date 2019-12
Publication Title Acta Medica Okayama
Volume volume73
Issue issue6
Publisher Okayama University Medical School
Start Page 543
End Page 546
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31871339
Web of Science KeyUT 000503431400012
FullText URL fulltext.pdf
Author Yamamoto, Haruchika| Miyoshi, Kentaroh| Otani, Shinji| Kurosaki, Takeshi| Sugimoto, Seiichiro| Yamane, Masaomi| Toyooka, Shinichi| Kobayashi, Motomu| Oto, Takahiro|
Keywords Inverted lung transplantation Pericardial conduit Pulmonary venous anastomosis Vessel formation
Published Date 2020-02-19
Publication Title BMC Pulmonary Medicine
Volume volume20
Issue issue1
Publisher BMC
Start Page 46
ISSN 1471-2466
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 32075616
DOI 10.1186/s12890-020-1075-4
Web of Science KeyUT 000517294200001
Related Url isVersionOf https://doi.org/10.1186/s12890-020-1075-4
FullText URL fulltext.pdf
Author Oto, Takahiro| Hikasa, Yukiko| Hagiyama, Akikazu| Kobayashi, Motomu|
Published Date 2020-06-21
Publication Title JTCVS Techniques
Volume volume3
Publisher Elsevier
Start Page 311
End Page 314
ISSN 26662507
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
DOI 10.1016/j.xjtc.2020.06.022
Related Url isVersionOf https://doi.org/10.1016/j.xjtc.2020.06.022