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ID 58287
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Katayama, Norihisa Department of Radiology, Okayama University Hospital Kaken ID researchmap
Sato, Shuhei Department of Radiology, Okayama University Hospital
Katsui, Kuniaki Department of Radiology, Okayama University Hospital ORCID Kaken ID publons
Takemoto, Mitsuhiro Department of Radiology, Okayama University Hospital
Tsuda, Toshihide Department of Radiology, Okayama University Hospital ORCID Kaken ID researchmap
Yoshida, Atsushi Department of Radiology, Okayama University Hospital
Morito, Tsuneharu Department of Radiology, Okayama University Hospital
Nakagawa, Tomio Department of Radiology, Okayama University Hospital
Mizutani, Akifumi Department of Radiology, Okayama University Hospital Kaken ID publons
Waki, Takahiro Department of Radiology, Okayama University Hospital ORCID
Niiya, Harutaka Department of Radiology, Okayama University Hospital
Kanazawa, Susumu Department of Radiology, Okayama University Hospital Kaken ID publons
Abstract
Purpose: To evaluate factors associated with radiation-induced bronchiolitis obliterans organizing pneumonia (BOOP) syndrome after breast-conserving therapy.
Methods and materials: A total of 702 women with breast cancer who received radiotherapy after breast-conserving surgery at seven institutions between July 1995 and December 2006 were analyzed. In all patients, the whole breast was irradiated with two tangential photon beams. The criteria used for the diagnosis of radiation-induced BOOP syndrome were as follows: (1) radiotherapy to the breast within 12 months, (2) general and/or respiratory symptoms lasting for >or=2 weeks, (3) radiographs showing lung infiltration outside the radiation port, and (4) no evidence of a specific cause.
Results: Radiation-induced BOOP syndrome was seen in 16 patients (2.3%). Eleven patients (68.8%) were administered steroids. The duration of steroid administration ranged from 1 week to 3.7 years (median, 1.1 years). Multivariate analysis revealed that age (>or=50 years; odds ratio [OR] 8.88; 95% confidence interval [CI] 1.16-67.76; p = 0.04) and concurrent endocrine therapy (OR 3.05; 95% CI 1.09-8.54; p = 0.03) were significantly associated with BOOP syndrome. Of the 161 patients whose age was >or=50 years and who received concurrent endocrine therapy, 10 (6.2%) developed BOOP syndrome.
Conclusions: Age (>or=50 years) and concurrent endocrine therapy can promote the development of radiation-induced BOOP syndrome after breast-conserving therapy. Physicians should carefully follow patients who received breast-conserving therapy, especially those who are older than 50 years and received concurrent endocrine therapy during radiotherapy.
Keywords
Breast cancer
Breast-conserving surgery
Radiotherapy
Radiation-induced BOOP syndrome
Endocrine therapy
Published Date
2009-03-15
Publication Title
International journal of radiation oncology, biology, physics
Volume
volume73
Issue
issue4
Publisher
Elsevier
Start Page
1049
End Page
1054
ISSN
0360-3016
NCID
AA00680920
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
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Web of Science KeyUT
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isVersionOf https://doi.org/10.1016/j.ijrobp.2008.05.050
License
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
Citation
Katayama N, Sato S, Katsui K, et al. Analysis of factors associated with radiation-induced bronchiolitis obliterans organizing pneumonia syndrome after breast-conserving therapy. Int J Radiat Oncol Biol Phys. 2009;73(4):1049‐1054. doi:10.1016/j.ijrobp.2008.05.050