start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=10
article-no=
start-page=566
end-page=571
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130710
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Vascularized peripheral nerve grafting promotes myelination of regrowing optic nerve
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We investigated whether the use of vascularized peripheral nerve grafts on the optic nerve stump enhances axonal regeneration of retinal ganglion cells compared with isolated nonvascularized grafts. The rat median nerve was microsurgically sutured with its supplying artery and vein to the optic nerve stump. The number of retinal ganglion cells with regenerating axons was evaluated by retrograde labeling into the grafted peripheral nerve, and the myelination of the regenerating axon fibers was examined by electron microscopy. The number of retinal ganglion cells with regenerating axons was significantly higher in the vascularized graft than in the nonvascularized graft. The ratio of myelinated axon fibers was also increased in vascularized grafts. Thus, grafting with their supplying arteries and veins to an injured nerve stump represents a promising strategy to accelerate axonal regeneration from neurons of the central nervous system.
en-copyright=
kn-copyright=

en-aut-name=KomatsuSeiji
en-aut-sei=Komatsu
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WakabayashiTaketoshi
en-aut-sei=Wakabayashi
en-aut-mei=Taketoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamadaKiyoshi
en-aut-sei=Yamada
en-aut-mei=Kiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MatsumotoKumiko
en-aut-sei=Matsumoto
en-aut-mei=Kumiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KimataYoshihiro
en-aut-sei=Kimata
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KosakaJun
en-aut-sei=Kosaka
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Univ, Grad Sch Med, Dept Plast & Reconstruct Surg

affil-num=2
en-affil=
kn-affil=Okayama Univ, Grad Sch Med, Dept Cytol & Histol

affil-num=3
en-affil=
kn-affil=Okayama Univ, Grad Sch Med, Dept Plast & Reconstruct Surg

affil-num=4
en-affil=
kn-affil=Okayama Univ, Grad Sch Med, Dept Plast & Reconstruct Surg

affil-num=5
en-affil=
kn-affil=Okayama Univ, Grad Sch Med, Dept Plast & Reconstruct Surg

affil-num=6
en-affil=
kn-affil=Kansai Med Univ, Dept Anat & Cell Sci
en-keyword=graft
kn-keyword=graft
en-keyword=microsurgery
kn-keyword=microsurgery
en-keyword=optic nerve
kn-keyword=optic nerve
en-keyword=retinal ganglion cells
kn-keyword=retinal ganglion cells
en-keyword=Schwann cells
kn-keyword=Schwann cells
en-keyword=vascularized nerve
kn-keyword=vascularized nerve
END