ID | 57574 |
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Author |
Wang, Yang
Graduate School of Environmental and Life Science , Okayama University
Hatabu, Toshimitsu
Graduate School of Environmental and Life Science , Okayama University
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Abstract | This study aimed to evaluate the microbial compositions and gene expression related to inflammation in dextran sodium sulfate (DSS)-induced acute colitis and the effect of mulberry supplementation. Male BALB/c mice received a diet supplemented with mulberry juice freeze-dried powder (MFP) or not for 3 weeks. After 3 weeks, the mice received water containing 5% (w/v) DSS or not for 1 week. The disease activity index score in mice fed MFP was significantly decreased. A significant decrease in Bifidobacterium spp. and the Clostridium perfringens subgroup was observed in mice not fed MFP. The number of goblet cell and NLRP6 expression were observed in mice fed a diet supplemented with MFP compared with mice not fed MFP. These results may indicate that mulberry mitigates DSS-induced acute colitis by a changing the gut microbial flora and by improving mucosal conditions.
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Keywords | DSS-induced acute colitis
Mulberry
NLRP6 inflammasome
goblet cell
microbiota
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Note | This fulltext will be available in Feb 2020
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Published Date | 2019-02-17
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Publication Title |
Bioscience, Biotechnology and Biochemistry
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Volume | volume83
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Issue | issue5
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Publisher | TAYLOR & FRANCIS
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Start Page | 914
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End Page | 922
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ISSN | 0916-8451
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NCID | AA10824164
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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File Version | author
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Related Url | isVersionOf https://doi.org/10.1080/09168451.2019.1580135
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