| FullText URL | fulltext.pdf |
|---|---|
| Author | Hatipoglu, Omer F.| Miyoshi, Toru| Yonezawa, Tomoko| Kondo, Megumi| Amioka, Naofumi| Yoshida, Masashi| Akagi, Satoshi| Nakamura, Kazufumi| Hirohata, Satoshi| Ito, Hiroshi| |
| Keywords | Aneurysm Aortic diseases |
| Published Date | 2020-04-22 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature |
| Start Page | 6869 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 32321956 |
| DOI | 10.1038/s41598-020-63824-9 |
| Web of Science KeyUT | 000560329100004 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-63824-9 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ohtsuki, Takashi| Hatipoglu, Omer F.| Asano, Keiichi| Inagaki, Junko| Nishida, Keiichiro| Hirohata, Satoshi| |
| Keywords | cell migration-inducing hyaluronidase 1 (CEMIP) chondrocyte hyaluronan mechanical strain nuclear factor kappa B (NF-kappa B) osteoarthritis |
| Published Date | 2020-04-29 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume21 |
| Issue | issue9 |
| Publisher | MDPI |
| Start Page | 3140 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32365591 |
| DOI | 10.3390/ijms21093140 |
| Web of Science KeyUT | 000535581700111 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms21093140 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ohtsuki, Takashi| Shinaoka, Akira| Kumagishi-Shinaoka, Kanae| Asano, Keiichi| Hatipoglu, Omer Faruk| Inagaki, Junko| Takahashi, Ken| Oohashi, Toshitaka| Nishida, Keiichiro| Naruse, Keiji| Hirohata, Satoshi| |
| Published Date | 2019-10-15 |
| Publication Title | Experimental Cell Research |
| Volume | volume383 |
| Issue | issue2 |
| Publisher | Elsevier |
| Start Page | 111556 |
| ISSN | 00144827 |
| Content Type | Journal Article |
| language | 英語 |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. Published by Elsevier Inc. |
| File Version | publisher |
| PubMed ID | 31415758 |
| DOI | 10.1016/j.yexcr.2019.111556 |
| Web of Science KeyUT | 000488145400017 |
| Related Url | isVersionOf https://doi.org/10.1016/j.yexcr.2019.111556 |
| JaLCDOI | 10.18926/AMO/53521 |
|---|---|
| FullText URL | 69_3_145.pdf |
| Author | Ishii, Hiroko| Kamikawa, Shigeshi| Hirohata, Satoshi| Mizutani, Akifumi| Abe, Koji| Seno, Masaharu| Oohashi, Toshitaka| Ninomiya, Yoshifumi| |
| Abstract | Eosinophil cationic protein (ECP) is well known as a cationic protein contained in the basic granules of activated eosinophils. Recent studies have reported that ECP exhibits novel activities on various types of cells, including rat neonatal cardiomyocytes. Here we evaluated the effects of ECP on rat cardiac myoblast H9c2 cells. Our results showed that ECP enhanced the survival of the cells, in part by promoting the ERK and Akt/GSK-3β signaling pathways. ECP attenuated the cytotoxic effects of H2O2 on H9c2 cells as well as the production of reactive oxygen species, the number of apoptotic cells and caspase 3/7 activity in the cells. In conclusion, ECP activated the ERK and Akt/GSK-3β pathways, resulting in anti-oxidative effects on H9c2 cells that attenuated apoptosis. |
| Keywords | ECP reactive oxygen species Akt ERK |
| Amo Type | Original Article |
| Published Date | 2015-06 |
| Publication Title | Acta Medica Okayama |
| Volume | volume69 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 145 |
| End Page | 153 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26101190 |
| Web of Science KeyUT | 000356903000003 |
| Author | Toeda, Kenichi| Nakamura, Keigo| Hirohata, Satoshi| Hatipoglu, Omer F.| Demircan, Kadir| Yamawaki, Hitoshi| Ogawa, Hiroko| Kusachi, Shozo| Shiratori, Yasushi| Ninomiya, Yoshifumi| |
|---|---|
| Published Date | 2005-12 |
| Publication Title | Molecular and Cellular Biochemistry |
| Volume | volume280 |
| Issue | issue1-2 |
| Content Type | Journal Article |
| Author | Demircan, Kadir| Hirohata, Satoshi| Nishida, Keiichiro| Hatipoglu, Omer F.| Oohashi, Toshitaka| Yonezawa, Tomoko| Apte, Suneel S.| Ninomiya, Yoshifumi| |
|---|---|
| Published Date | 2005-5 |
| Publication Title | Arthritis & Rheumatism |
| Volume | volume52 |
| Issue | issue5 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/31831 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Hatipoglu, Omer Faruk| Hirohata, Satoshi| Yaykasli, Kursat Oguz| Cilek, Mehmet Zeynel| Demircan, Kadir| Shinohata, Ryoko| Yonezawa, Tomoko| Oohashi, Toshitaka| Kusachi, Shozo| Ninomiya, Yoshifumi| |
| Abstract | <p>ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs 1) is an inflammatory-induced gene. We have previously reported that ADAMTS1 was strongly but transiently expressed in the infarcted heart. In this study, we investigated whether a 3'-untranslated region (UTR) affects the mRNA stability of this gene. When stimulated with tissue necrosis factor (TNF)-alpha, the expression level of ADAMTS1 mRNA rapidly increased, but the induction of ADAMTS1 mRNA peaked at 6h after stimulation, after which the expression levels of ADAMTS1 mRNA decreased. The 3'-UTR ADAMTS1 mRNA contains multiple adenine and uridine-rich elements, suggesting that the 3'-UTR may regulate gene stability. The addition of actinomycin D, an RNA synthesis inhibitor, demonstrated the decay of induced ADAMTS1 mRNA by TNF-alpha. Furthermore, a region containing multiple AUUUA motifs within the ADAMTS1 3'-UTR destabilized transfected Enhanced Green Fluorescence Protein (EGFP) mRNA expression. These results demonstrated that the ADAMTS1 3'-UTR may regulate the expression of ADAMTS1 mRNA.</p> |
| Keywords | ADAMTS1 gene regulation metalloproteinase |
| Amo Type | Original Article |
| Published Date | 2009-04 |
| Publication Title | Acta Medica Okayama |
| Volume | volume63 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 79 |
| End Page | 85 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | 英語 |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 19404339 |
| Web of Science KeyUT | 000265457600002 |
| Author | 廣畑 聡| |
|---|---|
| Published Date | 1997-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
