FullText URL fulltext.pdf
Author Yoshihara, Kumiko| Nagaoka, Noriyuki| Nakamura, Akiko| Hara, Toru| Hayakawa, Satoshi| Yoshida, Yasuhiro| Van Meerbeek, Meerbeek, Bart|
Published Date 2020-03-09
Publication Title Scientific Reports
Volume volume10
Issue issue1
Publisher Nature
Start Page 4387
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 32152430
DOI 10.1038/s41598-020-61111-1
Web of Science KeyUT 000563353700001
Related Url isVersionOf https://doi.org/10.1038/s41598-020-61111-1
FullText URL JACS7_1_90.pdf
Author Hayakawa, Satoshi| Okamoto, Keigo| Yoshioka, Tomohiko|
Keywords Titanium substrate apatite deposition simulated body fluid parallel alignment titania layer
Published Date 2019-02-11
Publication Title Journal of Asian Ceramic Societies
Volume volume7
Issue issue1
Publisher Taylor & Francis
Start Page 90
End Page 100
ISSN 2187-0764
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Author(s).
File Version publisher
DOI 10.1080/21870764.2019.1572690
Web of Science KeyUT 000459883500009
Related Url isVersionOf https://doi.org/10.1080/21870764.2019.1572690
FullText URL JACS20191699230.pdf
Author Liu, Xingzhu| Yoshioka, Tomohiko| Hayakawa, Satoshi|
Keywords Rutile nanorod arrays apatite rod density
Published Date 2019-12-02
Publication Title Journal of Asian Ceramic Societies
Publisher Taylor & Francis
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Author(s).
File Version publisher
DOI 10.1080/21870764.2019.1699230
Web of Science KeyUT 000500730700001
Related Url isVersionOf https://doi.org/10.1080/21870764.2019.1699230
JaLCDOI 10.18926/47027
FullText URL mfe_36_2_067_072.pdf
Author Yoshioka, Tomohiko| Tsuru, Kanji| Hayakawa, Satoshi| Osaka, Akiyoshi|
Abstract Alginic acid was immobilized on γ-aminopropyltriethoxysilane-coated glass as a model substrate since an alginic acid layer was known to prevent cell adhesion. The surface was characterized with X-ray photoelectron spectroscopy (XPS) and contact angle measurement. The coated substrates adsorbed practically no calcium phosphates on their surfaces when soaked in a simulated body fluid (SBF) of Kolrubo recipe. Since calcium ions are one of the factors for blood clotting, the present alginic acid coating is one of the candidates to improve blood compatibility of clinical materials.
Publication Title Memoirs of the Faculty of Engineering, Okayama University
Published Date 2002-03
Volume volume36
Issue issue2
Start Page 67
End Page 72
ISSN 0475-0071
language English
File Version publisher
NAID 80015582225
JaLCDOI 10.18926/47005
FullText URL mfe_36_1_117_121.pdf
Author Shirosaki, Yuki| Tsuru, Kanji| Hayakawa, Satoshi| Osaka, Akiyoshi| Takashima, Seisuke|
Abstract γ-Methacryloxypropyltrimethoxysilane (γ-MPS) was grafted to silicone due to emulsion polymerization to induce Si-OH groups, in order to provide silicone with bioactivity spontaneous deposition of apatite in body fluid and to improve cytocompatibility. Apatite deposited on the grafted silicone within 7 days of soaking in 1.5 times as concentrated as the Kokubo solution. Osteoblastic cells (MC3T3-E1) were cultured on the specimens up to 7 days. After 5 days of culture, the number of MC3T3-E1 cells on the grafted specimen was much greater than that on the original specimen. These results indicated that the biocompatibility of silicone elastomer was improved by the grafting γ-MPS.
Publication Title Memoirs of the Faculty of Engineering, Okayama University
Published Date 2001-12
Volume volume36
Issue issue1
Start Page 117
End Page 121
ISSN 0475-0071
language English
File Version publisher
NAID 120003497031
JaLCDOI 10.18926/19677
FullText URL Mem_Fac_Eng_OU_33_2_79.pdf
Author Osaka, Akiyoshi| Hayakawa, Satoshi| Koyano Keiko| Tsuru, Kanji|
Abstract A titanium oxide gel was electrochemically prepared on Ti with a cell consisting of Ti as the working electrode, Pt as the counter one, AgCl as the reference one, and an aqueous solution of 0.1 mol/L Ca(NO(3))(2) as the electrolyte solution. The Ti electrode was kept at 9.5V for 1 hr for oxidation and subsequently kept at-3.0V for 10 min (Ca9.5-3.0):calcium ions were expected to be adsorbed at the latter treatment. Other Ti specimen was kept at -3.0V for 10 min (Ca-3.0). Both specimens were found so bioactive as to deposit apatite in 12 hr (Ca9.5-3.0) and in 1 day (Ca-3.0) when soaked in a simulated body fluid (Kokubo solution). Calcium carbonate detected on the surface of Ca9.5-3.0 caused no harmful effects on spontaneous deposition of apatite in the fluid.
Publication Title Memoirs of the Faculty of Engineering, Okayama University
Published Date 1999-04-27
Volume volume33
Issue issue2
Start Page 79
End Page 84
ISSN 0475-0071
language Japanese
File Version publisher
NAID 120002309011
JaLCDOI 10.18926/19596
FullText URL Mem_Fac_Eng_OU_31_2_45.pdf
Author Osaka, Akiyoshi| Kobayashi Keizo| Hayakawa, Satoshi| Ohtsuki, Chikara|
Abstract The thermal expansion coefficient of some bioactive glasses in the system CaO-SiO(2)-B(2)O(3) were adjusted to be similar to that of titanium by controlling the composition. A glass of composition 45CaO・30SiO(2)・25B(2)O(3) was selected among those as the enameling glass. A slurry was prepared by mixing the glass powder and ethanal to be developed on titanium and heated at 740℃ for 30 min. Thus treated specimen was soaked in a simulated body fluid (Kokubo solutiion). FT-IR reflection and thin film X-ray diffraction analyses indicated apatite formation on the glass coating layer within 12 h of soaking in the fluid. Thus titanium could be provided with bioactivity due to the enameling.
Publication Title Memoirs of the Faculty of Engineering, Okayama University
Published Date 1997-03-28
Volume volume31
Issue issue2
Start Page 45
End Page 51
ISSN 0475-0071
language English
File Version publisher
NAID 120002309181
JaLCDOI 10.18926/19594
FullText URL Mem_Fac_Eng_OU_31_2_39.pdf
Author Imayoshi Naoki| Hayakawa, Satoshi| Ohtsuki, Chikara| Osaka, Akiyoshi|
Abstract Nb(2)O(5)-and Ta(2)O(5)-doped calcium si1icate glasses were soaked for various periods in a simulated body fluid(Kokubo solution) up to 30 days. Apatite formation ability of the surface of these glasses were investigated with thin-film X-ray diffraction and FT-IR reflection spectroscopy. The effects of these additive oxides on the bioactivity of CaO・SiO(2) based glass were discussed. A small amount of Nb(2)O(5) and Ta(2)O(5) suppressed the rate of silica hydrogel layer formation and the apatite formation on the surface of the glasses. The rate of the apatite nucleation on the surface of Nb(2)O(5)-doped calcium silicate glass was slower than that on the surface of Ta(2)O(5)-doped calcium silicate glass. It was concluded that the decrease in the apatite forming ability of calcium silicate glasses by these additive oxides is attributed to the suppression of formation of silica hydrogel layer which plays an important role in apatite nucleation.
Publication Title Memoirs of the Faculty of Engineering, Okayama University
Published Date 1997-03-28
Volume volume31
Issue issue2
Start Page 39
End Page 44
ISSN 0475-0071
language English
File Version publisher
NAID 120002309151
JaLCDOI 10.18926/15363
FullText URL Mem_Fac_Eng_OU_34_39.pdf
Author Hayakawa, Satoshi| Shirosaki, Yuki| Yabuta, Takeshi| Tsuru, Kanji| Ohtsuki Chikara| Osaka, Akiyoshi|
Abstract Silicone elastomer was chemically treated at 60℃ for 7 days with 30 wt% H(2)O(2) solutions with or without TaCl(5) and soaked for various periods in a simulated body fluid(Kokubo solution) up to 21 days. Apatite formation ability of the surface of the silicone elastomer specimens was investigated with thin-film X-ray diffraction and FT-IR reflection spectroscopy. These silicone specimens did not deposit apatite or calcium phosphates, irrespective of chemical treatment. Osteoblast-like cells (MC3T3-El) derived from mouse were cultured on the specimens at 36.5℃ under 5%C0(2) and 95% humidity. Similar degree of proliferation of cells was observed at 7 days among three specimens, while the no treatment specimen after incubation for 5 days showed a lower degree of proliferation than the silicone treated with 30 wt% H(2)O(2) solutions with or without TaCl(5). Alkaline phosphatase activity of the cells proliferated on the no treatment specimen was lower than those of the silicone treated with 30 wt% H(2)O(2) solutions with or without TaCl(5). These results indicate that the cytotoxicity of the silicone could be improved by the chemical treatment with 30 wt% H(2)O(2) solutions with or without TaCl(5).
Publication Title Memoirs of the Faculty of Engineering, Okayama University
Published Date 2000-03-27
Volume volume34
Issue issue1-2
Start Page 39
End Page 43
ISSN 0475-0071
language English
File Version publisher
NAID 120002308019