JaLCDOI | 10.18926/AMO/61424 |
---|---|
FullText URL | 75_1_1.pdf |
Author | Hamahara, Jun| Honda, Hiroyuki| Yamamoto, Koichiro| Tokumasu, Kazuki| Hanayama, Yoshihisa| Hagiya, Hideharu| Obika, Mikako| Ueda, Keigo| Kishida, Masayuki| Otsuka, Fumio| |
Abstract | To determine the clinical characteristics of low androgen status in adult males with diabetes, we retrospectively analyzed the medical records of patients with type 2 diabetes mellitus in whom serum free testosterone (FT) levels were examined for 1 year. Among the 46 patients (56 ± 1.5 years old), decreases in serum FT levels to < 8.5 pg/ml (indicating the occurrence of late-onset hypogonadism [LOH]) were detected in 18 (39%). The per-centages of patients with low FT levels were high in the ≥ 50 years age group (83%), the HbA1c < 7% group (67%), and the 25 ≤ BMI < 30 kg/m2 group (56%). The serum FT levels tended to decrease age-dependently. The level of HbA1c was significantly correlated with the Heinemann Aging Male Symptoms (AMS) score (R = 0.47). The low-FT group had decreased levels of hemoglobin. Of note, the serum FSH level (R = −0.32) was negatively correlated with the serum FT level, whereas the serum TSH level (R = 0.36) was positively correlated with the serum FT level. Collectively, these results revealed that many diabetic males may have low FT levels and that the AMS score is related to the HbA1c level. A slightly anemic condition, thyroid dysfunction, and obesity (class 1) might be involved in LOH in middle-aged diabetic males. |
Keywords | androgen diabetes mellitus late-onset hypogonadism testosterone thyroid function |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2021-02 |
Volume | volume75 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 1 |
End Page | 8 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33649607 |
JaLCDOI | 10.18926/AMO/64355 |
---|---|
FullText URL | 77_1_1.pdf |
Author | Nahar, Lutfun| Hagiya, Hideharu| Nada, Takahiro| Iio, Koji| Gotoh, Kazuyoshi| Matsushita, Osamu| Otsuka, Fumio| |
Abstract | Inducible resistance to the macrolide, lincosamide, and streptogramin B (iMLSB) antibiotic family is a latent mechanism for antimicrobial resistance in Staphylococcus aureus. We here investigated the frequency and genotypic profiles of iMLSB resistance in clindamycin (CLDM)-susceptible S. aureus isolated in Okayama University Hospital from June 2020 to June 2021. We phenotypically screened the iMLSB resistance via D-zone test and performed PCR testing for the erythromycin ribosomal methylase (erm) genes: ermA and ermC. Among 432 CLDM-susceptible S. aureus isolates, 138 (31.9%) exhibited an iMLSB-resistance phenotype, with methicillinresistant S. aureus isolates (MRSA; 61 isolates: 58.6%) exhibiting higher positivity than methicillin-sensitive S. aureus isolates (MSSA; 77 isolates: 23.5%) (p<0.001). Male patients had a higher frequency of iMLSB resistance than females (OR [95%CI]: 1.8 [1.2-2.8]; p=0.007). Genotypically, ermA predominated in both MSSA (70.1%) and MRSA (86.9%) compared to ermC (14.3% in MSSA and 11.5% in MRSA). A single strain of MRSA possessed both ermA and ermC, while 12 (15.6%) MSSA isolates were negative for both ermA and ermC, suggesting the presence of other genetic mechanisms. Collectively, these results show that approximately 33% of CLDM-susceptible S. aureus isolates at our university hospital exhibited iMLSB resistance, predominantly caused by ermA in both MSSA and MRSA. |
Keywords | antimicrobial resistance clindamycin erm D-zone test inducible MLSB |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2023-02 |
Volume | volume77 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 1 |
End Page | 9 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 36849140 |
Web of Science KeyUT | 000953663800001 |
FullText URL | fulltext.pdf |
---|---|
Author | Omura, Daisuke| Ogata, Masatoshi| Sakane, Yoshio| Matsuo, Ryuichi| Nakatsukasa, Harushige| Hagiya, Hideharu| Otsuka, Fumio| |
Keywords | aortic aneurysm Salmonella |
Published Date | 2020-09-20 |
Publication Title | Clinical Case Reports |
Volume | volume8 |
Issue | issue12 |
Publisher | Wiley |
Start Page | 3619 |
End Page | 3620 |
ISSN | 2050-0904 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 The Authors. |
File Version | publisher |
DOI | 10.1002/ccr3.3367 |
Web of Science KeyUT | 000570991600001 |
Related Url | isVersionOf https://doi.org/10.1002/ccr3.3367 |
FullText URL | fulltext.pdf |
---|---|
Author | Koyama, Toshihiro| Sasaki, Misato| Hagiya, Hideharu| Zamami, Yoshito| Funahashi, Tomoko| Ohshima, Ayako| Tatebe, Yasuhisa| Mikami, Naoko| Shinomiya, Kazuaki| Kitamura, Yoshihisa| Sendo, Toshiaki| Hinotsu, Shiro| Kano, Mitsunobu R.| |
Published Date | 2019-12-27 |
Publication Title | Scientific Reports |
Volume | volume9 |
Publisher | Nature Publishing Group |
Start Page | 20235 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2019 |
File Version | publisher |
PubMed ID | 31882673 |
DOI | 10.1038/s41598-019-56388-w |
Web of Science KeyUT | 000509351200002 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-019-56388-w |
FullText URL | fulltext.pdf |
---|---|
Author | Ueda, Yayoi| Tokumasu, Kazuki| Hagiya, Hideharu| Iio, Koji| Fujimori, Takumi| Kakehi, Ayaka| Okura, Mami| Minabe, Hiroshi| Otsuka, Fumio| |
Keywords | Mycobacterium chelonae Mycobacteremia Non-tuberculous mycobacteria Osteomyelitis Rapidly growing mycobacteria Rheumatoid arthritis |
Note | This fulltext is available in May 2021.| |
Published Date | 2020-05-11 |
Publication Title | Journal of Infection and Chemotherapy |
Volume | volume26 |
Issue | issue8 |
Publisher | Elsevier |
Start Page | 843 |
End Page | 846 |
ISSN | 1341321X |
NCID | AA11057978 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. |
File Version | author |
PubMed ID | 32402735 |
DOI | 10.1016/j.jiac.2020.03.004 |
Related Url | isVersionOf https://doi.org/10.1016/j.jiac.2020.03.004 |
FullText URL | fulltext.pdf |
---|---|
Author | Takao, Miyuki| Yoshioka, Nori| Hagiya, Hideharu| Deguchi, Matsuo| Kagita, Masanori| Tsukamoto, Hiroko| Hidaka, Yoh| Tomono, Kazunori| Tobe, Toru| |
Keywords | Blood and body fluid exposure Cytomegalovirus Healthcare workers Occupational infection Seroconversion |
Published Date | 2020-03-10 |
Publication Title | Journal of Infection and Chemotherapy |
Volume | volume26 |
Issue | issue7 |
Publisher | Elsevier |
Start Page | 681 |
End Page | 684 |
ISSN | 1341-321X |
NCID | AA11057978 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. |
File Version | author |
PubMed ID | 32169323 |
DOI | 10.1016/j.jiac.2020.02.011 |
Web of Science KeyUT | 000540280300007 |
Related Url | isVersionOf https://doi.org/10.1016/j.jiac.2020.02.011 |
FullText URL | fulltext.pdf |
---|---|
Author | Nishimura, Yoshito| Hagiya, Hideharu| Kawano, Kaoru| Yokota, Yuya| Oka, Kosuke| Iio, Koji| Hasegawa, Kou| Obika, Mikako| Haruma, Tomoko| Ono, Sawako| Masuyama, Hisashi| Otsuka, Fumio| |
Keywords | Non-typable Haemophilus influenzae Bacteremia beta-Lactamase-nonproducing ampicillin-resistance Adenomyosis Case report |
Published Date | 2020-07-16 |
Publication Title | BMC Infectious Diseases |
Volume | volume20 |
Issue | issue1 |
Publisher | BMC |
Start Page | 521 |
ISSN | 1471-2334 |
NCID | AA1203502X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s). 2020 |
File Version | publisher |
PubMed ID | 32678023 |
DOI | 10.1186/s12879-020-05193-2 |
Web of Science KeyUT | 000552431500010 |
Related Url | isVersionOf https://doi.org/10.1186/s12879-020-05193-2 |
FullText URL | JIC_26_10_1107_1109.pdf |
---|---|
Author | Hagiya, Hideharu| Ino, Hideo| Tokumasu, Kazuki| Ogawa, Hiroko| Miyoshi, Tomoko| Ochi, Kanako| Otsuka, Fumio| |
Keywords | Antimicrobial resistance Antibiotic literacy Antibiotics Students Medical education |
Note | This fulltext is available in July 2021.| |
Published Date | 2020-10 |
Publication Title | Journal of Infection and Chemotherapy |
Volume | volume26 |
Issue | issue10 |
Publisher | Elsevier |
Start Page | 1107 |
End Page | 1109 |
ISSN | 1341-321X |
NCID | AA11057978 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 32684385 |
DOI | 10.1016/j.jiac.2020.06.021 |
Web of Science KeyUT | 000561076200020 |
Related Url | isVersionOf https://doi.org/10.1016/j.jiac.2020.06.021 |
FullText URL | JIC_26_10_1095_1099.pdf |
---|---|
Author | Oka, Kosuke| Yamane, Mai| Yokota, Yuya| Yasuda, Miho| Hasegawa, Kou| Fujimori, Takumi| Iio, Koji| Hagiya, Hideharu| Otsuka, Fumio| |
Keywords | Disseminated infection Immunoproliferative disorders Non-tuberculous mycobacteria Osteomyelitis TAFRO syndrome |
Note | This fulltext is available in July 2021.| |
Published Date | 2020-10 |
Publication Title | Journal of Infection and Chemotherapy |
Volume | volume26 |
Issue | issue10 |
Publisher | Elsevier |
Start Page | 1095 |
End Page | 1099 |
ISSN | 1341-321X |
NCID | AA11057978 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 32684386 |
DOI | 10.1016/j.jiac.2020.06.020 |
Web of Science KeyUT | 000561076200017 |
Related Url | isVersionOf https://doi.org/10.1016/j.jiac.2020.06.020 |
FullText URL | InternMed_59_2067_2070.pdf |
---|---|
Author | Fukushima, Shinnosuke| Hagiya, Hideharu| Mizuta, Yuki| Nakano, Yasuhiro| Takahara, Masahiro| Okamoto, Kayo| Hayashi, Yuko| Yamada, Kiyoshi| Hasegawa, Kou| Otsuka, Fumio| |
Keywords | dentofacial abscesses odontogenic infection osteomyelitis multidrug resistance viridans Streptococcus |
Published Date | 2020-08-15 |
Publication Title | Internal Medicine |
Volume | volume59 |
Issue | issue16 |
Publisher | The Japanese Society of Internal Medicine |
Start Page | 2067 |
End Page | 2070 |
ISSN | 0918-2918 |
NCID | AA10827774 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | publisher |
PubMed ID | 32389944 |
NAID | 130007887682 |
DOI | 10.2169/internalmedicine.4283-20 |
Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.4283-20 |
FullText URL | JIC_26.pdf |
---|---|
Author | Haruki, Yuto| Hagiya, Hideharu| Haruki, Mai| Inoue, Yuta| Sugiyama, Tetsuhiro| |
Keywords | Acute kidney injury β-lactams Piperacillin/tazobactam Vancomycin |
Note | This fulltext is available in Oct. 2021.| |
Published Date | 2020-10 |
Publication Title | Journal of Infection and Chemotherapy |
Volume | volume26 |
Issue | issue10 |
Publisher | Elsevier |
Start Page | 1026 |
End Page | 1032 |
ISSN | 1341-321X |
NCID | AA11057978 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 32561128 |
DOI | 10.1016/j.jiac.2020.05.012 |
Web of Science KeyUT | 000561076200003 |
Related Url | isVersionOf https://doi.org/10.1016/j.jiac.2020.05.012 |
FullText URL | fulltext.pdf |
---|---|
Author | Nishimura, Yoshito| Hagiya, Hideharu| Obika, Mikako| Otsuka, Fumio| |
Keywords | septic pulmonary embolism blood culture procalcitonin |
Published Date | 2020-11-27 |
Publication Title | Pathogens |
Volume | volume9 |
Issue | issue12 |
Publisher | MDPI |
Start Page | 995 |
ISSN | 2076-0817 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 33260940 |
DOI | 10.3390/pathogens9120995 |
Web of Science KeyUT | 000602562400001 |
Related Url | isVersionOf https://doi.org/10.3390/pathogens9120995 |
FullText URL | fulltext.pdf |
---|---|
Author | Nishimura, Yoshito| Ochi, Kanako| Tokumasu, Kazuki| Obika, Mikako| Hagiya, Hideharu| Kataoka, Hitomi| Otsuka, Fumio| |
Keywords | COVID-19 online education depression pandemic anxiety medical student |
Published Date | 2021-02-18 |
Publication Title | Journal of Medical Internet Research |
Volume | volume23 |
Issue | issue2 |
Publisher | JMIR Publications |
Start Page | e25232 |
ISSN | 1438-8871 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © Yoshito Nishimura, Kanako Ochi, Kazuki Tokumasu, Mikako Obika, Hideharu Hagiya, Hitomi Kataoka, Fumio Otsuka. |
File Version | publisher |
PubMed ID | 33556033 |
DOI | 10.2196/25232 |
Web of Science KeyUT | 000619233300006 |
Related Url | isVersionOf https://doi.org/10.2196/25232 |
FullText URL | fulltext.pdf |
---|---|
Author | Nishimura, Yoshito| Miyoshi, Tomoko| Hagiya, Hideharu| Kosaki, Yoshinori| Otsuka, Fumio| |
Keywords | coronavirus disease 2019 (COVID-19) pandemic burnout prevention healthcare delivery system intention to leave |
Published Date | 2021-03-02 |
Publication Title | International Journal of Environmental Research and Public Health |
Volume | volume18 |
Issue | issue5 |
Publisher | MDPI |
Start Page | 2434 |
ISSN | 1660-4601 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 by the authors. |
File Version | publisher |
DOI | 10.3390/ijerph18052434 |
Web of Science KeyUT | 000628102900001 |
Related Url | isVersionOf https://doi.org/10.3390/ijerph18052434 |
FullText URL | fulltext20210623-2.pdf figure20210623-2.pdf |
---|---|
Author | Otsuka, Yuki| Hagiya, Hideharu| Nakano, Yasuhiro| Omura, Daisuke| Hasegawa, Kou| Yamada, Haruto| Iio, Koji| Honda, Tomoyuki| Otsuka, Fumio| |
Keywords | Human coronavirus Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 |
Note | © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.jiac.2021.05.001| |
Published Date | 2021-7 |
Publication Title | Journal of Infection and Chemotherapy |
Volume | volume27 |
Issue | issue7 |
Publisher | Elsevier BV |
Start Page | 1126 |
End Page | 1128 |
ISSN | 1341-321X |
NCID | AA11057978 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. |
File Version | author |
PubMed ID | 33994323 |
DOI | 10.1016/j.jiac.2021.05.001 |
Web of Science KeyUT | 000656910200036 |
Related Url | isVersionOf https://doi.org/10.1016/j.jiac.2021.05.001 |
FullText URL | fulltext.pdf |
---|---|
Author | Kageyama, Misaki| Hagiya, Hideharu| Ueda, Yasutaka| Ohtani, Katsuki| Fukumori, Yasuo| Inoue, Norimitsu| Wakamiya, Nobutaka| Yoneda, Nanoka| Kimura, Keigo| Nagasawa, Motonori| Nakagami, Futoshi| Nishi, Isao| Sugimoto, Ken| Rakugi, Hiromi| |
Keywords | complement addition test complement deficiency disseminated gonococcal infection genome analysis Neisseria gonorrhoeae sexually transmitted infection |
Published Date | 2021-04-02 |
Publication Title | Medicine |
Volume | volume100 |
Issue | issue13 |
Publisher | LIPPINCOTT WILLIAMS & WILKINS |
Start Page | e25265 |
ISSN | 0025-7974 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 the Author(s). |
File Version | publisher |
PubMed ID | 33787610 |
NAID | 120007098535 |
DOI | 10.1097/MD.0000000000025265 |
Web of Science KeyUT | 000658960700045 |
Related Url | isVersionOf https://doi.org/10.1097/MD.0000000000025265 |
FullText URL | fulltext.pdf |
---|---|
Author | Omura, Daisuke| Yunoki, Naoko| Otsuka, Yuki| Nakano, Yasuhiro| Hagiya, Hideharu| Otsuka, Fumio| |
Keywords | appendicitis barium |
Published Date | 2021-07-23 |
Publication Title | Clinical Case Reports |
Volume | volume9 |
Issue | issue7 |
Publisher | Wiley |
Start Page | e04583 |
ISSN | 2050-0904 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 The Authors. |
File Version | publisher |
PubMed ID | 34322273 |
DOI | 10.1002/ccr3.4583 |
Web of Science KeyUT | 000678684500144 |
Related Url | isVersionOf https://doi.org/10.1002/ccr3.4583 |
FullText URL | fulltext20210818-1.pdf |
---|---|
Author | Hagiya, Hideharu| Fujita, Koji| Kamiyama, Shinya| Ocho, Kazuki| Yamada, Haruto| Otsuka, Fumio| |
Keywords | antimicrobial resistance certified nurses in infection control infection prevention and control infectious disease doctors japan nosocomial infections surveillance |
Published Date | 2021-07-26 |
Publication Title | Cureus |
Volume | volume13 |
Issue | issue7 |
Publisher | Cureus Inc. |
Start Page | e16643 |
ISSN | 2168-8184 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © Copyright 2021 Hagiya et al. |
File Version | publisher |
DOI | 10.7759/cureus.16643 |
Web of Science KeyUT | 000680008700016 |
Related Url | isVersionOf https://doi.org/10.7759/cureus.16643 |
FullText URL | fulltext.pdf |
---|---|
Author | Fukushima, Shinnosuke| Hagiya, Hideharu| Otsuka, Yuki| Koyama, Toshihiro| Otsuka, Fumio| |
Published Date | 2021-03-31 |
Publication Title | Scientific Reports |
Volume | volume11 |
Issue | issue1 |
Publisher | Nature Portfolio |
Start Page | 7246 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2021 |
File Version | publisher |
PubMed ID | 33790327 |
DOI | 10.1038/s41598-021-86431-8 |
Web of Science KeyUT | 000684827000018 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-021-86431-8 |
JaLCDOI | 10.18926/AMO/60797 |
---|---|
FullText URL | 74_5_381.pdf |
Author | Yamamoto, Koichiro| Hanayama, Yoshihisa| Hasegawa, Kou| Tokumasu, Kazuki| Miyoshi, Tomoko| Hagiya, Hideharu| Ogawa, Hiroko| Obika, Mikako| Itoshima, Koichi| Otsuka, Fumio| |
Abstract | To clarify the relevance of prolactin (PRL) to clinical parameters in patients who visited our general medicine department, medical records of 353 patients in whom serum PRL levels were measured during the period from 2016 to 2018 were retrospectively reviewed. Data for 140 patients (M/F: 42/98) were analyzed after excluding patients lacking detailed records and patients taking dopaminergic agents. Median serum PRL levels were significantly lower in males than females: 6.5 ng/ml (IQR: 4.2-10.3) versus 8.1 ng/ml (5.9-12.9), respectively. Pain and general fatigue were the major symptoms at the first visit, and past histories of hypertension and dyslipidemia were frequent. Male patients with relatively high PRL levels (≥ 10 ng/ml) had significantly lower levels of serum albumin and significantly higher levels of serum LDH than those with low PRL (< 10 ng/ml). There were significant correlations of male PRL level with the erythrocyte sedimentation rate (R=0.62), serum LDH level (R=0.39) and serum albumin level (R=−0.52), while the level of serum CRP (R=0.33) showed an insignificant but weak positive correlation with PRL level. Collectively, these results show that PRL levels had gender-specific relevance to various clinical factors, with PRL levels in males being significantly related to inflammatory status. |
Keywords | hormones hyperprolactinemia inflammation pituitary prolactin |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2020-10 |
Volume | volume74 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 381 |
End Page | 389 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33106693 |
Web of Science KeyUT | 000581970100002 |
NAID | 120006892923 |