JaLCDOI 10.18926/AMO/61424
FullText URL 75_1_1.pdf
Author Hamahara, Jun| Honda, Hiroyuki| Yamamoto, Koichiro| Tokumasu, Kazuki| Hanayama, Yoshihisa| Hagiya, Hideharu| Obika, Mikako| Ueda, Keigo| Kishida, Masayuki| Otsuka, Fumio|
Abstract To determine the clinical characteristics of low androgen status in adult males with diabetes, we retrospectively analyzed the medical records of patients with type 2 diabetes mellitus in whom serum free testosterone (FT) levels were examined for 1 year. Among the 46 patients (56 ± 1.5 years old), decreases in serum FT levels to < 8.5 pg/ml (indicating the occurrence of late-onset hypogonadism [LOH]) were detected in 18 (39%). The per-centages of patients with low FT levels were high in the ≥ 50 years age group (83%), the HbA1c < 7% group (67%), and the 25 ≤ BMI < 30 kg/m2 group (56%). The serum FT levels tended to decrease age-dependently. The level of HbA1c was significantly correlated with the Heinemann Aging Male Symptoms (AMS) score (R = 0.47). The low-FT group had decreased levels of hemoglobin. Of note, the serum FSH level (R = −0.32) was negatively correlated with the serum FT level, whereas the serum TSH level (R = 0.36) was positively correlated with the serum FT level. Collectively, these results revealed that many diabetic males may have low FT levels and that the AMS score is related to the HbA1c level. A slightly anemic condition, thyroid dysfunction, and obesity (class 1) might be involved in LOH in middle-aged diabetic males.
Keywords androgen diabetes mellitus late-onset hypogonadism testosterone thyroid function
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-02
Volume volume75
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 8
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33649607
JaLCDOI 10.18926/AMO/64355
FullText URL 77_1_1.pdf
Author Nahar, Lutfun| Hagiya, Hideharu| Nada, Takahiro| Iio, Koji| Gotoh, Kazuyoshi| Matsushita, Osamu| Otsuka, Fumio|
Abstract Inducible resistance to the macrolide, lincosamide, and streptogramin B (iMLSB) antibiotic family is a latent mechanism for antimicrobial resistance in Staphylococcus aureus. We here investigated the frequency and genotypic profiles of iMLSB resistance in clindamycin (CLDM)-susceptible S. aureus isolated in Okayama University Hospital from June 2020 to June 2021. We phenotypically screened the iMLSB resistance via D-zone test and performed PCR testing for the erythromycin ribosomal methylase (erm) genes: ermA and ermC. Among 432 CLDM-susceptible S. aureus isolates, 138 (31.9%) exhibited an iMLSB-resistance phenotype, with methicillinresistant S. aureus isolates (MRSA; 61 isolates: 58.6%) exhibiting higher positivity than methicillin-sensitive S. aureus isolates (MSSA; 77 isolates: 23.5%) (p<0.001). Male patients had a higher frequency of iMLSB resistance than females (OR [95%CI]: 1.8 [1.2-2.8]; p=0.007). Genotypically, ermA predominated in both MSSA (70.1%) and MRSA (86.9%) compared to ermC (14.3% in MSSA and 11.5% in MRSA). A single strain of MRSA possessed both ermA and ermC, while 12 (15.6%) MSSA isolates were negative for both ermA and ermC, suggesting the presence of other genetic mechanisms. Collectively, these results show that approximately 33% of CLDM-susceptible S. aureus isolates at our university hospital exhibited iMLSB resistance, predominantly caused by ermA in both MSSA and MRSA.
Keywords antimicrobial resistance clindamycin erm D-zone test inducible MLSB
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-02
Volume volume77
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 9
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 36849140
Web of Science KeyUT 000953663800001
FullText URL fulltext.pdf
Author Omura, Daisuke| Ogata, Masatoshi| Sakane, Yoshio| Matsuo, Ryuichi| Nakatsukasa, Harushige| Hagiya, Hideharu| Otsuka, Fumio|
Keywords aortic aneurysm Salmonella
Published Date 2020-09-20
Publication Title Clinical Case Reports
Volume volume8
Issue issue12
Publisher Wiley
Start Page 3619
End Page 3620
ISSN 2050-0904
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
DOI 10.1002/ccr3.3367
Web of Science KeyUT 000570991600001
Related Url isVersionOf https://doi.org/10.1002/ccr3.3367
FullText URL fulltext.pdf
Author Koyama, Toshihiro| Sasaki, Misato| Hagiya, Hideharu| Zamami, Yoshito| Funahashi, Tomoko| Ohshima, Ayako| Tatebe, Yasuhisa| Mikami, Naoko| Shinomiya, Kazuaki| Kitamura, Yoshihisa| Sendo, Toshiaki| Hinotsu, Shiro| Kano, Mitsunobu R.|
Published Date 2019-12-27
Publication Title Scientific Reports
Volume volume9
Publisher Nature Publishing Group
Start Page 20235
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2019
File Version publisher
PubMed ID 31882673
DOI 10.1038/s41598-019-56388-w
Web of Science KeyUT 000509351200002
Related Url isVersionOf https://doi.org/10.1038/s41598-019-56388-w
FullText URL fulltext.pdf
Author Ueda, Yayoi| Tokumasu, Kazuki| Hagiya, Hideharu| Iio, Koji| Fujimori, Takumi| Kakehi, Ayaka| Okura, Mami| Minabe, Hiroshi| Otsuka, Fumio|
Keywords Mycobacterium chelonae Mycobacteremia Non-tuberculous mycobacteria Osteomyelitis Rapidly growing mycobacteria Rheumatoid arthritis
Note This fulltext is available in May 2021.|
Published Date 2020-05-11
Publication Title Journal of Infection and Chemotherapy
Volume volume26
Issue issue8
Publisher Elsevier
Start Page 843
End Page 846
ISSN 1341321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd.
File Version author
PubMed ID 32402735
DOI 10.1016/j.jiac.2020.03.004
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2020.03.004
FullText URL fulltext.pdf
Author Takao, Miyuki| Yoshioka, Nori| Hagiya, Hideharu| Deguchi, Matsuo| Kagita, Masanori| Tsukamoto, Hiroko| Hidaka, Yoh| Tomono, Kazunori| Tobe, Toru|
Keywords Blood and body fluid exposure Cytomegalovirus Healthcare workers Occupational infection Seroconversion
Published Date 2020-03-10
Publication Title Journal of Infection and Chemotherapy
Volume volume26
Issue issue7
Publisher Elsevier
Start Page 681
End Page 684
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
File Version author
PubMed ID 32169323
DOI 10.1016/j.jiac.2020.02.011
Web of Science KeyUT 000540280300007
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2020.02.011
FullText URL fulltext.pdf
Author Nishimura, Yoshito| Hagiya, Hideharu| Kawano, Kaoru| Yokota, Yuya| Oka, Kosuke| Iio, Koji| Hasegawa, Kou| Obika, Mikako| Haruma, Tomoko| Ono, Sawako| Masuyama, Hisashi| Otsuka, Fumio|
Keywords Non-typable Haemophilus influenzae Bacteremia beta-Lactamase-nonproducing ampicillin-resistance Adenomyosis Case report
Published Date 2020-07-16
Publication Title BMC Infectious Diseases
Volume volume20
Issue issue1
Publisher BMC
Start Page 521
ISSN 1471-2334
NCID AA1203502X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 32678023
DOI 10.1186/s12879-020-05193-2
Web of Science KeyUT 000552431500010
Related Url isVersionOf https://doi.org/10.1186/s12879-020-05193-2
FullText URL JIC_26_10_1107_1109.pdf
Author Hagiya, Hideharu| Ino, Hideo| Tokumasu, Kazuki| Ogawa, Hiroko| Miyoshi, Tomoko| Ochi, Kanako| Otsuka, Fumio|
Keywords Antimicrobial resistance Antibiotic literacy Antibiotics Students Medical education
Note This fulltext is available in July 2021.|
Published Date 2020-10
Publication Title Journal of Infection and Chemotherapy
Volume volume26
Issue issue10
Publisher Elsevier
Start Page 1107
End Page 1109
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32684385
DOI 10.1016/j.jiac.2020.06.021
Web of Science KeyUT 000561076200020
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2020.06.021
FullText URL JIC_26_10_1095_1099.pdf
Author Oka, Kosuke| Yamane, Mai| Yokota, Yuya| Yasuda, Miho| Hasegawa, Kou| Fujimori, Takumi| Iio, Koji| Hagiya, Hideharu| Otsuka, Fumio|
Keywords Disseminated infection Immunoproliferative disorders Non-tuberculous mycobacteria Osteomyelitis TAFRO syndrome
Note This fulltext is available in July 2021.|
Published Date 2020-10
Publication Title Journal of Infection and Chemotherapy
Volume volume26
Issue issue10
Publisher Elsevier
Start Page 1095
End Page 1099
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32684386
DOI 10.1016/j.jiac.2020.06.020
Web of Science KeyUT 000561076200017
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2020.06.020
FullText URL InternMed_59_2067_2070.pdf
Author Fukushima, Shinnosuke| Hagiya, Hideharu| Mizuta, Yuki| Nakano, Yasuhiro| Takahara, Masahiro| Okamoto, Kayo| Hayashi, Yuko| Yamada, Kiyoshi| Hasegawa, Kou| Otsuka, Fumio|
Keywords dentofacial abscesses odontogenic infection osteomyelitis multidrug resistance viridans Streptococcus
Published Date 2020-08-15
Publication Title Internal Medicine
Volume volume59
Issue issue16
Publisher The Japanese Society of Internal Medicine
Start Page 2067
End Page 2070
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 32389944
NAID 130007887682
DOI 10.2169/internalmedicine.4283-20
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.4283-20
FullText URL JIC_26.pdf
Author Haruki, Yuto| Hagiya, Hideharu| Haruki, Mai| Inoue, Yuta| Sugiyama, Tetsuhiro|
Keywords Acute kidney injury β-lactams Piperacillin/tazobactam Vancomycin
Note This fulltext is available in Oct. 2021.|
Published Date 2020-10
Publication Title Journal of Infection and Chemotherapy
Volume volume26
Issue issue10
Publisher Elsevier
Start Page 1026
End Page 1032
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32561128
DOI 10.1016/j.jiac.2020.05.012
Web of Science KeyUT 000561076200003
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2020.05.012
FullText URL fulltext.pdf
Author Nishimura, Yoshito| Hagiya, Hideharu| Obika, Mikako| Otsuka, Fumio|
Keywords septic pulmonary embolism blood culture procalcitonin
Published Date 2020-11-27
Publication Title Pathogens
Volume volume9
Issue issue12
Publisher MDPI
Start Page 995
ISSN 2076-0817
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 33260940
DOI 10.3390/pathogens9120995
Web of Science KeyUT 000602562400001
Related Url isVersionOf https://doi.org/10.3390/pathogens9120995
FullText URL fulltext.pdf
Author Nishimura, Yoshito| Ochi, Kanako| Tokumasu, Kazuki| Obika, Mikako| Hagiya, Hideharu| Kataoka, Hitomi| Otsuka, Fumio|
Keywords COVID-19 online education depression pandemic anxiety medical student
Published Date 2021-02-18
Publication Title Journal of Medical Internet Research
Volume volume23
Issue issue2
Publisher JMIR Publications
Start Page e25232
ISSN 1438-8871
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Yoshito Nishimura, Kanako Ochi, Kazuki Tokumasu, Mikako Obika, Hideharu Hagiya, Hitomi Kataoka, Fumio Otsuka.
File Version publisher
PubMed ID 33556033
DOI 10.2196/25232
Web of Science KeyUT 000619233300006
Related Url isVersionOf https://doi.org/10.2196/25232
FullText URL fulltext.pdf
Author Nishimura, Yoshito| Miyoshi, Tomoko| Hagiya, Hideharu| Kosaki, Yoshinori| Otsuka, Fumio|
Keywords coronavirus disease 2019 (COVID-19) pandemic burnout prevention healthcare delivery system intention to leave
Published Date 2021-03-02
Publication Title International Journal of Environmental Research and Public Health
Volume volume18
Issue issue5
Publisher MDPI
Start Page 2434
ISSN 1660-4601
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
DOI 10.3390/ijerph18052434
Web of Science KeyUT 000628102900001
Related Url isVersionOf https://doi.org/10.3390/ijerph18052434
FullText URL fulltext20210623-2.pdf figure20210623-2.pdf
Author Otsuka, Yuki| Hagiya, Hideharu| Nakano, Yasuhiro| Omura, Daisuke| Hasegawa, Kou| Yamada, Haruto| Iio, Koji| Honda, Tomoyuki| Otsuka, Fumio|
Keywords Human coronavirus Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2
Note © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.jiac.2021.05.001|
Published Date 2021-7
Publication Title Journal of Infection and Chemotherapy
Volume volume27
Issue issue7
Publisher Elsevier BV
Start Page 1126
End Page 1128
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
File Version author
PubMed ID 33994323
DOI 10.1016/j.jiac.2021.05.001
Web of Science KeyUT 000656910200036
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2021.05.001
FullText URL fulltext.pdf
Author Kageyama, Misaki| Hagiya, Hideharu| Ueda, Yasutaka| Ohtani, Katsuki| Fukumori, Yasuo| Inoue, Norimitsu| Wakamiya, Nobutaka| Yoneda, Nanoka| Kimura, Keigo| Nagasawa, Motonori| Nakagami, Futoshi| Nishi, Isao| Sugimoto, Ken| Rakugi, Hiromi|
Keywords complement addition test complement deficiency disseminated gonococcal infection genome analysis Neisseria gonorrhoeae sexually transmitted infection
Published Date 2021-04-02
Publication Title Medicine
Volume volume100
Issue issue13
Publisher LIPPINCOTT WILLIAMS & WILKINS
Start Page e25265
ISSN 0025-7974
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 the Author(s).
File Version publisher
PubMed ID 33787610
NAID 120007098535
DOI 10.1097/MD.0000000000025265
Web of Science KeyUT 000658960700045
Related Url isVersionOf https://doi.org/10.1097/MD.0000000000025265
FullText URL fulltext.pdf
Author Omura, Daisuke| Yunoki, Naoko| Otsuka, Yuki| Nakano, Yasuhiro| Hagiya, Hideharu| Otsuka, Fumio|
Keywords appendicitis barium
Published Date 2021-07-23
Publication Title Clinical Case Reports
Volume volume9
Issue issue7
Publisher Wiley
Start Page e04583
ISSN 2050-0904
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Authors.
File Version publisher
PubMed ID 34322273
DOI 10.1002/ccr3.4583
Web of Science KeyUT 000678684500144
Related Url isVersionOf https://doi.org/10.1002/ccr3.4583
FullText URL fulltext20210818-1.pdf
Author Hagiya, Hideharu| Fujita, Koji| Kamiyama, Shinya| Ocho, Kazuki| Yamada, Haruto| Otsuka, Fumio|
Keywords antimicrobial resistance certified nurses in infection control infection prevention and control infectious disease doctors japan nosocomial infections surveillance
Published Date 2021-07-26
Publication Title Cureus
Volume volume13
Issue issue7
Publisher Cureus Inc.
Start Page e16643
ISSN 2168-8184
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Copyright 2021 Hagiya et al.
File Version publisher
DOI 10.7759/cureus.16643
Web of Science KeyUT 000680008700016
Related Url isVersionOf https://doi.org/10.7759/cureus.16643
FullText URL fulltext.pdf
Author Fukushima, Shinnosuke| Hagiya, Hideharu| Otsuka, Yuki| Koyama, Toshihiro| Otsuka, Fumio|
Published Date 2021-03-31
Publication Title Scientific Reports
Volume volume11
Issue issue1
Publisher Nature Portfolio
Start Page 7246
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 33790327
DOI 10.1038/s41598-021-86431-8
Web of Science KeyUT 000684827000018
Related Url isVersionOf https://doi.org/10.1038/s41598-021-86431-8
JaLCDOI 10.18926/AMO/60797
FullText URL 74_5_381.pdf
Author Yamamoto, Koichiro| Hanayama, Yoshihisa| Hasegawa, Kou| Tokumasu, Kazuki| Miyoshi, Tomoko| Hagiya, Hideharu| Ogawa, Hiroko| Obika, Mikako| Itoshima, Koichi| Otsuka, Fumio|
Abstract To clarify the relevance of prolactin (PRL) to clinical parameters in patients who visited our general medicine department, medical records of 353 patients in whom serum PRL levels were measured during the period from 2016 to 2018 were retrospectively reviewed. Data for 140 patients (M/F: 42/98) were analyzed after excluding patients lacking detailed records and patients taking dopaminergic agents. Median serum PRL levels were significantly lower in males than females: 6.5 ng/ml (IQR: 4.2-10.3) versus 8.1 ng/ml (5.9-12.9), respectively. Pain and general fatigue were the major symptoms at the first visit, and past histories of hypertension and dyslipidemia were frequent. Male patients with relatively high PRL levels (≥ 10 ng/ml) had significantly lower levels of serum albumin and significantly higher levels of serum LDH than those with low PRL (< 10 ng/ml). There were significant correlations of male PRL level with the erythrocyte sedimentation rate (R=0.62), serum LDH level (R=0.39) and serum albumin level (R=−0.52), while the level of serum CRP (R=0.33) showed an insignificant but weak positive correlation with PRL level. Collectively, these results show that PRL levels had gender-specific relevance to various clinical factors, with PRL levels in males being significantly related to inflammatory status.
Keywords hormones hyperprolactinemia inflammation pituitary prolactin
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-10
Volume volume74
Issue issue5
Publisher Okayama University Medical School
Start Page 381
End Page 389
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33106693
Web of Science KeyUT 000581970100002
NAID 120006892923