| JaLCDOI |
10.18926/AMO/32101
|
| FullText URL |
fulltext.pdf
|
| Author |
Zhang, Shan|
Takeda, Yoshimasa|
Hagioka, Shingo|
Goto, Keiji|
Morita, Kiyoshi|
|
| Abstract |
<p>To elucidate the mechanism by which hyperbaric oxygen (HBO2) induces electrical discharge, changes in the extracellular concentrations of GABA and glutamate were measured every 5 min using a microdialysis technique in rats during a period of exposure to HBO2 (5 atm abs). Electrical discharge was observed at 28 +/- 4 min after the onset of exposure. Though the extracellular concentrations of glutamate remained unchanged, the extracellular GABA concentrations (pre-exposure level, 0.026 +/- 0.005 microM in dialysate) began to decrease 15 min after the onset of exposure and reached their lowest level (74 +/- 14%, 0.019 +/- 0.004 microM) at the time of appearance of the discharge. There was a close logistic relationship between extracellular GABA concentrations and the discharge incidence, and the extracellular concentrations of GABA causing electrical discharge in 50% of the animals were estimated to be 80% of the pre-exposure level. These results suggest a possible mechanism that HBO2 exposure-induced discharge is caused by the decrease in extracellular concentration of GABA.</p>
|
| Keywords |
glutamic acid
hyperbaric oxygenation
gamma-aminobutyricacid
microdialysis
seizures
|
| Amo Type |
Article
|
| Published Date |
2004-04
|
| Publication Title |
Acta Medica Okayama
|
| Volume |
volume58
|
| Issue |
issue2
|
| Publisher |
Okayama University Medical School
|
| Start Page |
91
|
| End Page |
95
|
| ISSN |
0386-300X
|
| NCID |
AA00508441
|
| Content Type |
Journal Article
|
| language |
英語
|
| File Version |
publisher
|
| Refereed |
True
|
| PubMed ID |
15255510
|
| Web of Science KeyUT |
000221043700005
|
