JaLCDOI 10.18926/AMO/66915
FullText URL 78_2_123.pdf
Author Saeki, Kyosuke| Fujiwara, Hideaki| Seike, Keisuke| Kuroi, Taiga| Nishimori, Hisakazu| Tanaka, Takehiro| Matsuoka, Ken-ichi| Fujii, Nobuharu| Maeda, Yoshinobu|
Abstract Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HCT), but its pathogenesis remains unclear. Recently, haplo-identical HCT with post-transplant cyclophosphamide (Haplo-HCT with PTCY) was found to achieve a low incidence rate of acute GVHD and chronic GVHD. However, while the pathogenesis of acute GVHD following Haplo-HCT with PTCY has been well investigated, that of chronic GVHD remains to be elucidated, especially in HLA-matched HCT with PTCY. Based on its safety profile, PTCY is currently applied for the human leucocyte antigen (HLA)-matched HCT setting. Here, we investigated the mechanisms of chronic GVHD following HLA-matched HCT with PTCY using a well-defined mouse chronic GVHD model. PTCY attenuated clinical and pathological chronic GVHD by suppressing effector T-cells and preserving regulatory T-cells compared with a control group. Additionally, we demonstrated that cyclosporine A (CsA) did not show any additional positive effects on attenuation of GVHD in PTCY-treated recipients. These results suggest that monotherapy with PTCY without CsA could be a promising strategy for the prevention of chronic GVHD following HLA-matched HCT.
Keywords GVHD posttransplant cyclophosphamide hematopoietic cell transplantation HLA-identical
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-04
Volume volume78
Issue issue2
Publisher Okayama University Medical School
Start Page 123
End Page 134
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
JaLCDOI 10.18926/AMO/65740
FullText URL 77_4_347.pdf
Author Iwamuro, Masaya| Kondo, Takumi| Ennishi, Daisuke| Fujii, Nobuharu| Matsuoka, Ken-ichi| Takahashi, Takahide| Hirabata, Araki| Tanaka, Takehiro| Otsuka, Fumio| Maeda, Yoshinobu| Okada, Hiroyuki|
Abstract The feasibility of lymphocyte isolation and flow cytometry using a single endoscopic biopsy specimen from the gastrointestinal tract of patients who have undergone hematopoietic stem cell transplantation has not been investigated. We acquired 51 endoscopic biopsy specimens from the gastrointestinal tract of 35 patients. We divided the flow cytometry samples into two groups: group A, successful lymphocyte isolation (n=24), and group B, incomplete isolation (n=27). We compared the backgrounds of the samples between the groups to reveal crucial elements in the successful isolation of lymphocytes residing in the gastrointestinal tract. Comparison between the groups revealed lymphocyte isolation success rates differed between biopsy sites. Isolation was most successful in samples from the duodenum (8/9, 88.9%), followed by the ileum (4/8, 50.0%), large intestine (4/11, 36.4%), and stomach (8/23, 34.8%). Tacrolimus was used more frequently in group B (92.6%) than in group A (62.5%) (p=0.015). Logistic regression analysis revealed that isolation from the duodenum or ileum was a significant factor for successful isolation, while tacrolimus use was not statistically significant. In conclusion, the duodenum and ileum are more suitable sites than the stomach and colorectum for acquiring samples for flow cytometry.
Keywords flow cytometry stem cell transplantation transplantation-associated microangiopathy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-08
Volume volume77
Issue issue4
Publisher Okayama University Medical School
Start Page 347
End Page 357
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37635134
Web of Science KeyUT 001163659800002
FullText URL fulltext20240213-01.pdf
Author Urata, Tomohiro| Naoi, Yusuke| Jiang, Aixiang| Boyle, Merrill| Sunami, Kazutaka| Imai, Toshi| Nawa, Yuichiro| Hiramatsu, Yasushi| Yamamoto, Kazuhiko| Fujii, Soichiro| Yoshida, Isao| Yano, Tomofumi| Chijimatsu, Ryota| Murakami, Hiroyuki| Ikeuchi, Kazuhiro| Kobayashi, Hiroki| Tani, Katsuma| Ujiie, Hideki| Inoue, Hirofumi| Tomida, Shuta| Yamamoto, Akira| Kondo, Takumi| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Fujii, Nobuharu| Matsuoka, Ken-ichi| Sawada, Keisuke| Momose, Shuji| Tamaru, Jun-ichi| Nishikori, Asami| Sato, Yasuharu| Yoshino, Tadashi| Maeda, Yoshinobu| Scott, David W.| Ennishi, Daisuke|
Published Date 2023-12-14
Publication Title Blood Advances
Volume volume7
Issue issue24
Publisher American Society of Hematology
Start Page 7459
End Page 7470
ISSN 2473-9529
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 by The American Society of Hematology.
File Version publisher
PubMed ID 37552496
DOI 10.1182/bloodadvances.2023010402
Web of Science KeyUT 001141306600001
Related Url isVersionOf https://doi.org/10.1182/bloodadvances.2023010402
FullText URL fulltext20230708-01.pdf
Author Matsuo, Toshihiko| Tanaka, Takehiro| Okada, Kazuya| Notohara, Kenji| Fujii, Keiko| Fujii, Nobuharu|
Keywords mantle cell lymphoma lacrimal gland autologous peripheral blood stem cell transplantation breast cancer tracheal and bronchial infiltration
Published Date 2023-07-05
Publication Title Journal of Investigative Medicine High Impact Case Reports
Volume volume11
Publisher SAGE Publications
ISSN 2324-7096
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 American Federation for Medical Research
File Version publisher
PubMed ID 37403948
DOI 10.1177/23247096231185483
Related Url isVersionOf https://doi.org/10.1177/23247096231185483
Author Kondo, Takumi| Fujii, Keiko| Fujii, Nobuharu| Sumii, Yuichi| Urata, Tomohiro| Kimura, Maiko| Matsuda, Masayuki| Ikegawa, Shuntaro| Washio, Kana| Fujiwara, Hideaki| Asada, Noboru| Ennishi, Daisuke| Nishimori, Hisakazu| Matsuoka, Ken‐ichi| Otsuka, Fumio| Maeda, Yoshinobu|
Keywords blood center operations cellular therapy therapeutic apheresis
Note This is the peer reviewed version of the following article: [Kondo, T, Fujii, K, Fujii, N, Sumii, Y, Urata, T, Kimura, M, et al. Efficient granulocyte collection method using high concentrations of medium molecular weight hydroxyethyl starch. Transfusion. 2023. https://doi.org/10.1111/trf.17450], which has been published in final form at [https://doi.org/10.1111/trf.17450]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| This fulltext file will be available in Jun. 2024.|
Published Date 2023-06-09
Publication Title Transfusion
Publisher Wiley
ISSN 0041-1132
NCID AA00868753
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 AABB.
File Version author
PubMed ID 37293978
DOI 10.1111/trf.17450
Web of Science KeyUT 001004560100001
Related Url isVersionOf https://doi.org/10.1111/trf.17450
FullText URL fulltext.pdf
Author Murakami, Hiroyuki| Matsuoka, Ken-Ichi| Asano, Takeru| Moriyama, Takashi| Matsumura, Akifumi| Fujiwara, Hideaki| Asada, Noboru| Ennishi, Daisuke| Nishimori, Hisakazu| Fujii, Keiko| Fujii, Nobuharu| Toji, Tomohiro| Yoshino, Tadashi| Maeda, Yoshinobu|
Keywords Refractory acute myeloid leukemia Transplant B-cell lymphoma-2 Azacitidine Venetoclax
Published Date 2022-11-08
Publication Title Case Reports In Oncology
Volume volume15
Issue issue3
Publisher Karger
Start Page 974
End Page 979
ISSN 1662-6575
NCID AA12780955
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 The Author(s).
File Version publisher
PubMed ID 36636684
DOI 10.1159/000526697
Web of Science KeyUT 000905485600025
Related Url isVersionOf https://doi.org/10.1159/000526697
FullText URL fulltext.pdf
Author Yamasuji-Maeda, Yoshiko| Nishimori, Hisakazu| Seike, Keisuke| Yamamoto, Akira| Fujiwara, Hideaki| Kuroi, Taiga| Saeki, Kyosuke| Fujinaga, Haruko| Okamoto, Sachiyo| Matsuoka, Ken-Ichi| Fujii, Nobuharu| Tanaka, Takehiro| Fujii, Masahiro| Mominoki, Katsumi| Kanekura, Takuro| Maeda, Yoshinobu|
Published Date 2022-09-09
Publication Title PLOS One
Volume volume17
Issue issue9
Publisher Public Library Science
Start Page e0273749
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 Yamasuji-Maeda et al.
File Version publisher
PubMed ID 36084023
DOI 10.1371/journal.pone.0273749
Web of Science KeyUT 000892051000058
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0273749
FullText URL fulltext20221006-1.pdf
Author Matsuo, Toshihiko| Tanaka, Takehiro| Fujii, Nobuharu| Fujii, Kentaro| Kondo, Eisei|
Published Date 2022
Publication Title Journal of Clinical and Experimental Hematopathology
Volume volume62
Issue issue3
Publisher Japanese Society for Lymphoreticular Tissue Research
Start Page 187
End Page 189
ISSN 1346-4280
NCID AA11556796
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2022 by The Japanese Society for Lymphoreticular Tissue Research
File Version publisher
PubMed ID 35732410
DOI 10.3960/jslrt.22007
Related Url isVersionOf https://doi.org/10.3960/jslrt.22007
FullText URL fulltext.pdf
Author Kitamura, Wataru| Asada, Noboru| Tabata, Tetsuya| Shibata, Rei| Nishi, Tatsuya| Kato, Yuka| Takasuka, Hiroki| Fujiwara, Hideaki| Ennishi, Daisuke| Nishimori, Hisakazu| Fujii, Nobuharu| Matsuoka, Ken-Ichi| Kiura, Katsuyuki| Yoshino, Tadashi| Maeda, Yoshinobu|
Keywords marginal zone lymphoma diffuse large B-cell lymphoma anterior mediastinum cystic lesions
Published Date 2022
Publication Title Journal Of Clinical And Experimental Hematopatholo
Volume volume62
Issue issue1
Publisher The Japanese Society for Lymphoreticular Tissue Research
Start Page 35
End Page 40
ISSN 1346-4280
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Japanese Society for Lymphoreticular Tissue Research
File Version publisher
PubMed ID 34840205
DOI 10.3960/jslrt.21010
Web of Science KeyUT 000766876600003
Related Url isVersionOf https://doi.org/10.3960/jslrt.21010
FullText URL fulltext.pdf
Author Kitamura, Wataru| Ennishi, Daisuke| Yukawa, Ryoya| Sasaki, Ryo| Yoshida, Chikamasa| Takasuka, Hiroki| Fujiwara, Hideaki| Asada, Noboru| Nishimori, Hisakazu| Fujii, Keiko| Fujii, Nobuharu| Matsuoka, Ken-Ichi| Abe, Koji| Yoshino, Tadashi| Maeda, Yoshinobu|
Keywords peripheral T-cell lymphoma chorea single photon-emission computed tomography
Published Date 2021-10-01
Publication Title Internal Medicine
Volume volume60
Issue issue19
Publisher The Japanese Society of Internal Medicine
Start Page 3155
End Page 3160
ISSN 0918-2918
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 33814503
DOI 10.2169/internalmedicine.7180-21
Web of Science KeyUT 000706487700015
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.7180-21
FullText URL fulltext.pdf
Author Okawa, Sachi| Rai, Kammei| Fujii, Nobuharu| Gion, Yuka| Ninomiya, Kiichiro| Kato, Yuka| Taniguchi, Akihiko| Kubo, Toshio| Ichihara, Eiki| Ohashi, Kadoaki| Miyahara, Nobuaki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki|
Keywords EGFR IgG4-related disease marginal zone lymphoma osimertinib
Published Date 2021-09-01
Publication Title Internal Medicine
Volume volume60
Issue issue17
Publisher The Japanese Society of Internal Medicine
Start Page 2831
End Page 2837
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 33775999
DOI 10.2169/internalmedicine.6470-20
Web of Science KeyUT 000695856000020
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.6470-20
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Fujii, Nobuharu| Tanaka, Takehiro| Kanzaki, Hiromitsu| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki|
Keywords esophagogastroduodenoscopy squamous metaplasia gastrointestinal lymphoma
Published Date 2021-07-15
Publication Title Internal Medicine
Volume volume60
Issue issue14
Publisher The Japanese Society of Internal Medicine
Start Page 2229
End Page 2234
ISSN 0918-2918
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 33612676
DOI 10.2169/internalmedicine.6271-20
Web of Science KeyUT 000674801700010
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.6271-20
FullText URL fulltext.pdf
Author Matsuoka, Natsumi| Watanabe, Haruki| Kurooka, Naoko| Kato, Sumari| Higashi, Chika| Tanabe, Katsuyuki| Kinomura, Masaru| Fujii, Nobuharu| Sada, Ken-Ei| Sugiyama, Hitoshi| Wada, Jun|
Keywords acute kidney injury Evans syndrome autoimmune hemolytic anemia
Published Date 2021-04-01
Publication Title Internal Medicine
Volume volume60
Issue issue7
Publisher Japanese Society of Internal Medicine
Start Page 1055
End Page 1060
ISSN 0918-2918
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 33116016
NAID 120007042384
DOI 10.2169/internalmedicine.5976-20
Web of Science KeyUT 000637009100013
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.5976-20
FullText URL fulltext.pdf
Author Yamamoto, Akira| Fujii, Nobuharu| Obika, Mikako| Yamashita, Taro| Otsuka, Fumio|
Keywords localized AL amyloidosis ymphadenopathy PET-CT systemic AL amyloidosis
Published Date 2020-10-01
Publication Title Internal Medicine
Volume volume59
Issue issue19
Publisher The Japanese Society of Internal Medicine
Start Page 2415
End Page 2418
ISSN 1349-7235
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 32611959
DOI 10.2169/internalmedicine.4651-20
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.4651-20
FullText URL fulltext.pdf
Author Sugiura, Hiroyuki| Nishimori, Hisakazu| Nishii, Kazuya| Toji, Tomohiro| Fujii, Keiko| Fujii, Nobuharu| Matsuoka, Ken-ichi| Nakata, Koh| Kiura, Katsuyuki| Maeda, Yoshinobu|
Keywords pulmonary alveolar proteinosis primary myelofibrosis autopsy ruxolitinib
Published Date 2020-08-15
Publication Title Internal Medicine
Volume volume59
Issue issue16
Start Page 2023
End Page 2028
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 32448830
DOI 10.2169/internalmedicine.4082-19
Web of Science KeyUT 000563078400014
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.4082-19
Author Kobayashi, Hiroki| Asada, Noboru| Igawa, Takuro| Abe, Masaya| Meguri, Yusuke| Ennishi, Daisuke| Nishimori, Hisakazu| Fujii, Nobuharu| Matsuoka, Ken-ichi| Yoshino, Tadashi| Maeda, Yoshinobu|
Keywords adult T-cell leukemia-lymphoma breast involvement positron emission tomography/computed tomography
Published Date 2020-11-01
Publication Title Internal Medicine
Volume volume59
Issue issue21
Publisher 日本内科学会
Start Page 2757
End Page 2761
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by The Japanese Society of Internal Medicine
File Version publisher
DOI 10.2169/internalmedicine.5077-20
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.5077-20
FullText URL fulltext.pdf
Author Sando, Yasuhisa| Matsuoka, Ken-Ichi| Sumii, Yuichi| Kondo, Takumi| Ikegawa, Shuntaro| Sugiura, Hiroyuki| Nakamura, Makoto| Iwamoto, Miki| Meguri, Yusuke| Asada, Noboru| Ennishi, Daisuke| Nishimori, Hisakazu| Fujii, Keiko| Fujii, Nobuharu| Utsunomiya, Atae| Oka, Takashi| Maeda, Yoshinobu|
Keywords T-cell lymphoma Targeted therapies
Published Date 2020-10-14
Publication Title Scientific Reports
Volume volume10
Issue issue1
Publisher Nature Research
Start Page 17237
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 33057055
DOI 10.1038/s41598-020-74174-x
Web of Science KeyUT 000582678700031
Related Url isVersionOf https://doi.org/10.1038/s41598-020-74174-x
Title Alternative Chimeric antigen receptor (CAR)-T cell therapy
FullText URL 132_34.pdf
Author Fujii, Nobuharu|
Publication Title Journal of Okayama Medical Association
Published Date 2020-04-01
Volume volume132
Issue issue1
Start Page 34
End Page 36
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.132.34
language Japanese
Copyright Holders Copyright (c) 2020 岡山医学会
File Version publisher
DOI 10.4044/joma.132.34
NAID 130007840317
Author Iwatani, Kayoko| Takata, Katsuyoshi| Sato, Yasuharu| Miyata-Takata, Tomoko| Iwaki, Noriko| Cui, Wei| Sawada-Kitamura, Seiko| Sonobe, Hiroshi| Tamura, Maiko| Saito, Katsuhiko| Miyatani, Katsuya| Yamasaki, Rie| Yamadori, Ichiro| Fujii, Nobuharu| Terasaki, Yasushi| Maeda, Yoshinobu| Tanimoto, Mitsune| Nakamura, Naoya| Yoshino, Tadashi|
Published Date 2014-07
Publication Title Human Pathology
Volume volume45
Issue issue7
Content Type Journal Article
Author Sugiyama, Haruko| Maeda, Yoshinobu| Nishimori, Hisakazu| Yamasuji, Yoshiko| Matsuoka, Ken-ichi| Fujii, Nobuharu| Kondo, Eisei| Shinagawa, Katsuji| Tanaka, Takehiro| Takeuchi, Kengo| Teshima, Takanori| Tanimoto, Mitsune|
Published Date 2014-02
Publication Title Biology of Blood and Marrow Transplantation
Volume volume20
Issue issue2
Content Type Journal Article